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Conserved domains on  [gi|22749331|ref|NP_689868|]
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zinc finger protein 585A isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-474 4.57e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 4.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 129 KPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQ--CGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQK------- 199
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 200 -------------------------------STLKMHQKIHTGERSYIC--------------IECGQAFIQKTHLIAHR 234
Cdd:COG5048 112 ssssnsndnnllsshslppssrdpqlpdllsISNLRNNPLPGNNSSSVNtpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 235 RIHTGEKPYECSNCGKSFISKSQLQVHQRVHtRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSEL 314
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 315 IIHQRIHTGE-------KPYECSDCGKAFTQKSALTVHQR--IHTGE--KSYIC--MKCGLAFIQKAHLIAHQIIHTGEK 381
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 382 PHKC--GHCGKLFTSKS-----QLHVHKRIHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKS--YICSKCGKAFTQ 450
Cdd:COG5048 351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 22749331 451 RSDLITHQRIHTGEKPYECNTCGK 474
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
KRAB super family cl42959
krueppel associated box;
1-30 1.03e-07

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.13  E-value: 1.03e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 22749331      1 MLETYSHLLSVGYQVPEAEVV-MLEQGKEPW 30
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLIsQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
421-713 1.14e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 421 TNRSNLITHQKTHTGE----KSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKS------HLNIHQKIH- 489
Cdd:COG5048  12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrHLRTHHNNPs 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 490 ----------------------TGERQYECHECGKAFNQKSILI----VHQKIHTGEKP-YVCTECGRAFIRKSNFI--- 539
Cdd:COG5048  92 dlnskslplsnskasssslsssSSNSNDNNLLSSHSLPPSSRDPqlpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHppl 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 540 ----------------THQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTG 603
Cdd:COG5048 172 panslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 604 EKPYICSECGKTFRQKSELITHHRIHTGE-------KPYECSDCGKSFTKKSQLQVHQR--IHTGE--KPYVCAE--CGK 670
Cdd:COG5048 252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 22749331 671 AFTDRSNLNKHQTTHTGDKPYKC--GICGKGFVQKSVFSVHQSSH 713
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-474 4.57e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 4.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 129 KPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQ--CGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQK------- 199
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 200 -------------------------------STLKMHQKIHTGERSYIC--------------IECGQAFIQKTHLIAHR 234
Cdd:COG5048 112 ssssnsndnnllsshslppssrdpqlpdllsISNLRNNPLPGNNSSSVNtpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 235 RIHTGEKPYECSNCGKSFISKSQLQVHQRVHtRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSEL 314
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 315 IIHQRIHTGE-------KPYECSDCGKAFTQKSALTVHQR--IHTGE--KSYIC--MKCGLAFIQKAHLIAHQIIHTGEK 381
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 382 PHKC--GHCGKLFTSKS-----QLHVHKRIHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKS--YICSKCGKAFTQ 450
Cdd:COG5048 351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 22749331 451 RSDLITHQRIHTGEKPYECNTCGK 474
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
KRAB smart00349
krueppel associated box;
1-30 1.03e-07

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.13  E-value: 1.03e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 22749331      1 MLETYSHLLSVGYQVPEAEVV-MLEQGKEPW 30
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLIsQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
421-713 1.14e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 421 TNRSNLITHQKTHTGE----KSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKS------HLNIHQKIH- 489
Cdd:COG5048  12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrHLRTHHNNPs 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 490 ----------------------TGERQYECHECGKAFNQKSILI----VHQKIHTGEKP-YVCTECGRAFIRKSNFI--- 539
Cdd:COG5048  92 dlnskslplsnskasssslsssSSNSNDNNLLSSHSLPPSSRDPqlpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHppl 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 540 ----------------THQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTG 603
Cdd:COG5048 172 panslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 604 EKPYICSECGKTFRQKSELITHHRIHTGE-------KPYECSDCGKSFTKKSQLQVHQR--IHTGE--KPYVCAE--CGK 670
Cdd:COG5048 252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 22749331 671 AFTDRSNLNKHQTTHTGDKPYKC--GICGKGFVQKSVFSVHQSSH 713
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
650-673 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....
gi 22749331   650 LQVHQRIHTGEKPYVCAECGKAFT 673
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   453 DLITHQRIHTGEKPYECNTCGKAFTQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-474 4.57e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 4.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 129 KPFKCNECGKSFFQVSSLFRHQRIHTGEKLYECSQ--CGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQK------- 199
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 200 -------------------------------STLKMHQKIHTGERSYIC--------------IECGQAFIQKTHLIAHR 234
Cdd:COG5048 112 ssssnsndnnllsshslppssrdpqlpdllsISNLRNNPLPGNNSSSVNtpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 235 RIHTGEKPYECSNCGKSFISKSQLQVHQRVHtRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSEL 314
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 315 IIHQRIHTGE-------KPYECSDCGKAFTQKSALTVHQR--IHTGE--KSYIC--MKCGLAFIQKAHLIAHQIIHTGEK 381
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 382 PHKC--GHCGKLFTSKS-----QLHVHKRIHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKS--YICSKCGKAFTQ 450
Cdd:COG5048 351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 22749331 451 RSDLITHQRIHTGEKPYECNTCGK 474
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-713 1.97e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 281 SNNSNLVTHKKVQSREKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSD--CGKAFTQKSALTVHQRIHTGEKSYICM 358
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 359 KCG------LAFIQKAHLIAHQIIHTGEKPHKCGHcgKLFTSKSQLHVHKRIHTGEKPYMCNKCGKAfTNRSNLITHQKT 432
Cdd:COG5048  96 KSLplsnskASSSSLSSSSSNSNDNNLLSSHSLPP--SSRDPQLPDLLSISNLRNNPLPGNNSSSVN-TPQSNSLHPPLP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 433 HTgeksyicSKCGKAFTQRSDLItHQRIHTGEKPYECNTCGKAFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILiv 512
Cdd:COG5048 173 AN-------SLSKDPSSNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLS-- 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 513 hqkihtgekpyvctecgrafIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTG-EKPYVCAECGKAFSGR 591
Cdd:COG5048 243 --------------------QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRS 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 592 SNLSKHQKT--HTGE--KPYICSE--CGKTFRQKSELITHHRIHTGEKPYEC--SDCGKSFTKKS-----QLQVHQRIHT 658
Cdd:COG5048 303 SPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLK 382

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22749331 659 GEKPYVCA--ECGKAFTDRSNLNKHQTTHTGDKP--YKCGICGKGFVQKSVFSVHQSSH 713
Cdd:COG5048 383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-627 4.33e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 213 RSYICIECGQAFIQKTHLIAHRRIHTGEKPYECS--NCGKSFISKSQLQVHQRVHTRVKPYIC--TEYGKVFSNNSNLVT 288
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 289 HKKVQSReKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSDCGKAF--TQKSALTVHQRIHTgeksyicMKCGLAFIQ 366
Cdd:COG5048 112 SSSSNSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPAN-------SLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 367 KAHLIAHQIIHTGEKPHKCGHCGKLFTSKSQLHVHKRIHTgEKPYMCNKCGKAFT------NRSNLITHQKTHTGEKSYI 440
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 441 CSKCGKAFTQRSDLITHQRIHTG-EKPYECNTCGKAFTQKSHLNIHQ--KIHTGE--RQYECHE--CGKAFNQKSILIVH 513
Cdd:COG5048 263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 514 QKIHTGEKPYVC--TECGRAFIRKSN-----FITHQRIHTGEKPYECSD--CGKSFTSKSQLLVHQPVHTGEKPYVC--A 582
Cdd:COG5048 343 ILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknP 422

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 22749331 583 ECGKAFSGRSNLSKHQKTHTgEKPYICSECGKTFRQKSELITHHR 627
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-560 2.04e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 157 KLYECSQCGKGFSYNSDLSIHEKIHTGERHHECTDCGKAFTQKSTLK---MHQKIHTGERSYICIECGQAFIQKTHLIAH 233
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsrHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 234 RRIHTGEKPYECSNCGKSFISKSQlqvhqrvhTRVKPYICTEYGKVFSNNSNLVTHKKVQSREKSSICT--ECGKAFTYR 311
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDP--------QLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 312 SELIIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAF------IQKAHLIAHQIIHTGEKPHKC 385
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 386 GHCGKLFTSKSQLHVHKRIHTG-EKPYMCNKCGKAFTNRSNLITHQKT--HTGE--KSYIC--SKCGKAFTQRSDLITHQ 458
Cdd:COG5048 264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 459 RIHTGEKPYECNTC------GKAFTQKSHLNIHQ-KIHTGERQYEC--HECGKAFNQKSILIVHQKIHTGEKPYVC--TE 527
Cdd:COG5048 344 LLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQyKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                       410       420       430
                ....*....|....*....|....*....|...
gi 22749331 528 CGRAFIRKSNFITHQRIHTGEKPYECSDCGKSF 560
Cdd:COG5048 424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
KRAB smart00349
krueppel associated box;
1-30 1.03e-07

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.13  E-value: 1.03e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 22749331      1 MLETYSHLLSVGYQVPEAEVV-MLEQGKEPW 30
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLIsQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
421-713 1.14e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 421 TNRSNLITHQKTHTGE----KSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKS------HLNIHQKIH- 489
Cdd:COG5048  12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrHLRTHHNNPs 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 490 ----------------------TGERQYECHECGKAFNQKSILI----VHQKIHTGEKP-YVCTECGRAFIRKSNFI--- 539
Cdd:COG5048  92 dlnskslplsnskasssslsssSSNSNDNNLLSSHSLPPSSRDPqlpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHppl 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 540 ----------------THQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTG 603
Cdd:COG5048 172 panslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 604 EKPYICSECGKTFRQKSELITHHRIHTGE-------KPYECSDCGKSFTKKSQLQVHQR--IHTGE--KPYVCAE--CGK 670
Cdd:COG5048 252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 22749331 671 AFTDRSNLNKHQTTHTGDKPYKC--GICGKGFVQKSVFSVHQSSH 713
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-292 4.95e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 129 KPFKCNECGKSFFQVSSLFRHQR--IHTGEKLYECSQ----CGKGFSYNSDLSIHEKIHTGERHHEC--TDCGKAFTQKS 200
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 201 TLK-----MHQKIHTGERSYICI--ECGQAFIQKTHLIAHRRIHTGEKPYECSN--CGKSFISKSQLQVHQRVHTRVKPY 271
Cdd:COG5048 368 NNEppqslQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170       180
                ....*....|....*....|.
gi 22749331 272 ICTEYGKvFSNNSNLVTHKKV 292
Cdd:COG5048 448 LCSILKS-FRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 407-487 6.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 6.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 407 GEKPYMCN--KCGKAFTNRSNLITHQKThtgeksyicSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSHLNI 484
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 22749331 485 HQK 487
Cdd:COG5189 417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
650-673 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....
gi 22749331   650 LQVHQRIHTGEKPYVCAECGKAFT 673
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   453 DLITHQRIHTGEKPYECNTCGKAFTQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-562 3.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   537 NFITHQRIHTGEKPYECSDCGKSFTS 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 631-698 3.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.52e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749331 631 GEKPYECS--DCGKSFTKKSQLQVHqRIHtgekpyvcAECGKAFTDRSNLNKHQTTHTGDKPYKCGICGK 698
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 3.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   313 ELIIHQRIHTGEKPYECSDCGKAFTQ 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 5.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   481 HLNIHQKIHTGERQYECHECGKAFNQ 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 635-657 5.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|...
gi 22749331   635 YECSDCGKSFTKKSQLQVHQRIH 657
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 6.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   229 HLIAHRRIHTGEKPYECSNCGKSFIS 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-646 7.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749331   621 ELITHHRIHTGEKPYECSDCGKSFTK 646
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 411-433 9.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.73e-03
                          10        20
                  ....*....|....*....|...
gi 22749331   411 YMCNKCGKAFTNRSNLITHQKTH 433
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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