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Conserved domains on  [gi|110815804|ref|NP_694807|]
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DDB1- and CUL4-associated factor 10 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13237336)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-326 5.60e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 5.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 171 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 248
Cdd:cd00200  130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110815804 249 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTedgcPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 326
Cdd:cd00200  209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 524-562 3.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110815804   524 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 562
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-326 5.60e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 5.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 171 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 248
Cdd:cd00200  130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110815804 249 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTedgcPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 326
Cdd:cd00200  209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
175-326 2.55e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 175 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 253
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110815804 254 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnrcTEDG-CPHKKFFHTRFLMRMRLTPDcSKMLISTSS 326
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD----LATGeLLRTLTGHSGGVNSVAFSPD-GKLLASGSD 308
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 251-288 1.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 110815804   251 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 288
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
250-288 6.58e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110815804  250 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 288
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 231-288 1.17e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110815804 231 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 288
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 524-562 3.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110815804   524 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 562
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-326 5.60e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 5.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 171 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 248
Cdd:cd00200  130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110815804 249 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTedgcPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 326
Cdd:cd00200  209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
175-326 2.55e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 175 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 253
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110815804 254 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnrcTEDG-CPHKKFFHTRFLMRMRLTPDcSKMLISTSS 326
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD----LATGeLLRTLTGHSGGVNSVAFSPD-GKLLASGSD 308
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-326 7.82e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 7.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 176 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 254
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVR 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110815804 255 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSS 326
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSS 154
WD40 COG2319
WD40 repeat [General function prediction only];
176-326 1.69e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 176 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 254
Cdd:COG2319  205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLAT-GELLR 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110815804 255 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnrcTEDGCPHKKF-FHTRFLMRMRLTPDcSKMLISTSS 326
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD----LATGKLLRTLtGHTGAVRSVAFSPD-GKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
176-290 2.01e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 2.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 176 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSeAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 254
Cdd:COG2319  289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLAT-GELLR 366

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 110815804 255 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTN 290
Cdd:COG2319  367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
175-336 8.55e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 8.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 175 HGAVFNLEYSPDGSVLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 253
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 254 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnrcTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 333
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231


                 ...
gi 110815804 334 ELD 336
Cdd:COG2319  232 DLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-343 2.62e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 2.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 176 GAVFNLEYSPDG-SVLTVACEQTeVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 253
Cdd:cd00200   52 GPVRDVAASADGtYLASGSSDKT-IRLWDLETGECVRTL-TGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVET-GKCL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 254 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD--TNRCtedgcphKKFF--HTRFLMRMRLTPDcSKMLISTSSGYL 329
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlrTGKC-------VATLtgHTGEVNSVAFSPD-GEKLLSSSSDGT 200

                        170
                 ....*....|....
gi 110815804 330 LILHELDLTKSLEV 343
Cdd:cd00200  201 IKLWDLSTGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-288 1.46e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 176 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 254
Cdd:cd00200  178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRT-GECVQ 255

                         90       100       110
                 ....*....|....*....|....*....|....
gi 110815804 255 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 288
Cdd:cd00200  256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
175-247 6.97e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 6.97e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110815804 175 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLR 247
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 251-288 1.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 110815804   251 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 288
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
250-288 6.58e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110815804  250 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 288
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 231-288 1.17e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110815804 231 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 288
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-245 1.36e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 110815804   206 SSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 245
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-341 4.97e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 4.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815804 253 VCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTedgcpHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLL 330
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-----LLRTLkgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90
                 ....*....|.
gi 110815804 331 ILHELDLTKSL 341
Cdd:cd00200   76 RLWDLETGECV 86
WD40 pfam00400
WD domain, G-beta repeat;
207-245 7.65e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 110815804  207 SKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 245
Cdd:pfam00400   1 GKLLKTL-EGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 524-562 3.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 110815804   524 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 562
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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