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Conserved domains on  [gi|194097479|ref|NP_703195|]
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gap junction alpha-8 protein [Rattus norvegicus]

Protein Classification

Connexin and Connexin50 domain-containing protein( domain architecture ID 11981468)

Connexin and Connexin50 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 3-235 3.31e-145

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


:

Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 412.66  E-value: 3.31e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097479    3 DWSFQGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQI 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097479   83 IFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDqasirkssssskgtkkfRLEGTLLRTYVCHI 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEEELYEEEGKKEAEPKV-----------------HIRGGLLWTYVLSL 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194097479  163 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLG 235
Cdd:pfam00029 144 LFRIVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLG 216
Connexin50 pfam03509
Gap junction alpha-8 protein (Cx50);
267-333 5.07e-36

Gap junction alpha-8 protein (Cx50);


:

Pssm-ID: 460951  Cd Length: 65  Bit Score: 126.82  E-value: 5.07e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097479  267 IQKAKGYQLLEEEKIVSHYFPLTEVGMvETSPLSAkPFSQFEEKIGTGPLADMSRGYQETLPSYAQV 333
Cdd:pfam03509   1 IQKAKGYKLLEEEKPVSHYFPLTEVGM-EASPLPA-PFEGFEEKSGEGPLEDISKAYDETLPSYAQV 65
Connexin40_C super family cl46284
Connexin 40 C-terminal domain; This is the C-terminal domain of connexin 40. It interacts with ...
 419-440 1.99e-04

Connexin 40 C-terminal domain; This is the C-terminal domain of connexin 40. It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop pf connexin 40.


The actual alignment was detected with superfamily member pfam16791:

Pssm-ID: 480624  Cd Length: 106  Bit Score: 40.49  E-value: 1.99e-04
                          10        20
                  ....*....|....*....|..
gi 194097479  419 DNRPLSRLSKASSRARSDDLTI 440
Cdd:pfam16791  85 DKRRLSKTSGTSSRARSDDLSV 106
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 3-235 3.31e-145

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 412.66  E-value: 3.31e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097479    3 DWSFQGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQI 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097479   83 IFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDqasirkssssskgtkkfRLEGTLLRTYVCHI 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEEELYEEEGKKEAEPKV-----------------HIRGGLLWTYVLSL 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194097479  163 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLG 235
Cdd:pfam00029 144 LFRIVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLG 216
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
168-234 1.66e-39

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 136.08  E-value: 1.66e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097479   168 FEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHL 234
Cdd:smart01089   1 LEVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
Connexin50 pfam03509
Gap junction alpha-8 protein (Cx50);
267-333 5.07e-36

Gap junction alpha-8 protein (Cx50);


Pssm-ID: 460951  Cd Length: 65  Bit Score: 126.82  E-value: 5.07e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097479  267 IQKAKGYQLLEEEKIVSHYFPLTEVGMvETSPLSAkPFSQFEEKIGTGPLADMSRGYQETLPSYAQV 333
Cdd:pfam03509   1 IQKAKGYKLLEEEKPVSHYFPLTEVGM-EASPLPA-PFEGFEEKSGEGPLEDISKAYDETLPSYAQV 65
Connexin40_C pfam16791
Connexin 40 C-terminal domain; This is the C-terminal domain of connexin 40. It interacts with ...
 419-440 1.99e-04

Connexin 40 C-terminal domain; This is the C-terminal domain of connexin 40. It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop pf connexin 40.


Pssm-ID: 465272  Cd Length: 106  Bit Score: 40.49  E-value: 1.99e-04
                          10        20
                  ....*....|....*....|..
gi 194097479  419 DNRPLSRLSKASSRARSDDLTI 440
Cdd:pfam16791  85 DKRRLSKTSGTSSRARSDDLSV 106
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 3-235 3.31e-145

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 412.66  E-value: 3.31e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097479    3 DWSFQGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQI 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097479   83 IFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDqasirkssssskgtkkfRLEGTLLRTYVCHI 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEEELYEEEGKKEAEPKV-----------------HIRGGLLWTYVLSL 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194097479  163 IFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLG 235
Cdd:pfam00029 144 LFRIVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLG 216
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
168-234 1.66e-39

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 136.08  E-value: 1.66e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097479   168 FEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHL 234
Cdd:smart01089   1 LEVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
Connexin50 pfam03509
Gap junction alpha-8 protein (Cx50);
267-333 5.07e-36

Gap junction alpha-8 protein (Cx50);


Pssm-ID: 460951  Cd Length: 65  Bit Score: 126.82  E-value: 5.07e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097479  267 IQKAKGYQLLEEEKIVSHYFPLTEVGMvETSPLSAkPFSQFEEKIGTGPLADMSRGYQETLPSYAQV 333
Cdd:pfam03509   1 IQKAKGYKLLEEEKPVSHYFPLTEVGM-EASPLPA-PFEGFEEKSGEGPLEDISKAYDETLPSYAQV 65
CNX smart00037
Connexin homologues; Connexin channels participate in the regulation of signaling between ...
 44-76 4.16e-24

Connexin homologues; Connexin channels participate in the regulation of signaling between developing and differentiated cell types.


Pssm-ID: 128352  Cd Length: 34  Bit Score: 94.05  E-value: 4.16e-24
                           10        20        30
                   ....*....|....*....|....*....|...
gi 194097479    44 VWGDEQSDFVCNTQQPGCENVCYDEAFPISHIR 76
Cdd:smart00037   2 VWGDEQSDFVCNTQQPGCENVCYDQAFPISHVR 34
Connexin40_C pfam16791
Connexin 40 C-terminal domain; This is the C-terminal domain of connexin 40. It interacts with ...
 419-440 1.99e-04

Connexin 40 C-terminal domain; This is the C-terminal domain of connexin 40. It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop pf connexin 40.


Pssm-ID: 465272  Cd Length: 106  Bit Score: 40.49  E-value: 1.99e-04
                          10        20
                  ....*....|....*....|..
gi 194097479  419 DNRPLSRLSKASSRARSDDLTI 440
Cdd:pfam16791  85 DKRRLSKTSGTSSRARSDDLSV 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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