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Conserved domains on  [gi|1985464785|ref|NP_715639|]
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interleukin-19 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL10 super family cl02501
Interleukin 10;
21-167 1.26e-04

Interleukin 10;


The actual alignment was detected with superfamily member pfam00726:

Pssm-ID: 413341  Cd Length: 170  Bit Score: 40.74  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464785  21 DNHGLRRCLISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLetLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPK 99
Cdd:pfam00726  23 ECGCTHQPDSFPHMlRELRDAFSRVKTFFQTKDQLDNLLLTESL--LEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPE 100
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1985464785 100 ILRKISSIANSFLYMQKTLRQCQEQRQChcrQEATNATRVIHDNYDQLEvHAAAIKSLGELDVFLAWI 167
Cdd:pfam00726 101 IKEHVNSLGEKLKTLRLRLRRCHRFLPC---ENKSKAVEKVKNAFNKLQ-EKGVYKAMSEFDIFINYI 164
 
Name Accession Description Interval E-value
IL10 pfam00726
Interleukin 10;
21-167 1.26e-04

Interleukin 10;


Pssm-ID: 334228  Cd Length: 170  Bit Score: 40.74  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464785  21 DNHGLRRCLISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLetLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPK 99
Cdd:pfam00726  23 ECGCTHQPDSFPHMlRELRDAFSRVKTFFQTKDQLDNLLLTESL--LEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPE 100
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1985464785 100 ILRKISSIANSFLYMQKTLRQCQEQRQChcrQEATNATRVIHDNYDQLEvHAAAIKSLGELDVFLAWI 167
Cdd:pfam00726 101 IKEHVNSLGEKLKTLRLRLRRCHRFLPC---ENKSKAVEKVKNAFNKLQ-EKGVYKAMSEFDIFINYI 164
IL10 smart00188
Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, ...
34-167 4.60e-04

Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.


Pssm-ID: 128485  Cd Length: 137  Bit Score: 38.69  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464785   34 MHHIEESFQEIKRAIQAKDTFPNvtILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLY 113
Cdd:smart00188   5 LRELRAAFSRVKTFFQMKDQLDN--ILLTESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKT 82
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1985464785  114 MQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHaaaiKSLGELDVFLAWI 167
Cdd:smart00188  83 LRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGVY----KAMSEFDIFINYI 132
 
Name Accession Description Interval E-value
IL10 pfam00726
Interleukin 10;
21-167 1.26e-04

Interleukin 10;


Pssm-ID: 334228  Cd Length: 170  Bit Score: 40.74  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464785  21 DNHGLRRCLISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLetLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPK 99
Cdd:pfam00726  23 ECGCTHQPDSFPHMlRELRDAFSRVKTFFQTKDQLDNLLLTESL--LEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPE 100
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1985464785 100 ILRKISSIANSFLYMQKTLRQCQEQRQChcrQEATNATRVIHDNYDQLEvHAAAIKSLGELDVFLAWI 167
Cdd:pfam00726 101 IKEHVNSLGEKLKTLRLRLRRCHRFLPC---ENKSKAVEKVKNAFNKLQ-EKGVYKAMSEFDIFINYI 164
IL10 smart00188
Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, ...
34-167 4.60e-04

Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.


Pssm-ID: 128485  Cd Length: 137  Bit Score: 38.69  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464785   34 MHHIEESFQEIKRAIQAKDTFPNvtILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLY 113
Cdd:smart00188   5 LRELRAAFSRVKTFFQMKDQLDN--ILLTESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKT 82
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1985464785  114 MQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHaaaiKSLGELDVFLAWI 167
Cdd:smart00188  83 LRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGVY----KAMSEFDIFINYI 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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