BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  31 LADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAES 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 320544409 111 LQVKG 115
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  31 LADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAES 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 320544409 111 LQVKG 115
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409    33 DVILSCDGVVFKAHKLILAACSKKFADLFENTPTN-GQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESL 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*
gi 320544409   112 QVKGL 116
Cdd:smart00225  81 QIPGL 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  31 LADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAES 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 320544409 111 LQVKG 115
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409    33 DVILSCDGVVFKAHKLILAACSKKFADLFENTPTN-GQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESL 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*
gi 320544409   112 QVKGL 116
Cdd:smart00225  81 QIPGL 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  12 NSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFEN-TPTNGQCVIILEATTPDNMAALLEFMY 90
Cdd:cd18242    2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSeMSEKGKSEVELQGLTASTMEILLDFVY 81

                         90       100
                 ....*....|....*....|....*
gi 320544409  91 KGEVHVSQEALNSFLKSAESLQVKG 115
Cdd:cd18242   82 TETVHVTVENVQELLPAACLLQLKG 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  21 TFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNG-QCVIILEATTPDNMAALLEFMYKGEVHVSQE 99
Cdd:cd18240    7 VFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETeKKVYKIPGVSPEMMELIIEYAYTRTVPITAE 86

                         90
                 ....*....|....*..
gi 320544409 100 ALNSFLKSAESLQVKGL 116
Cdd:cd18240   87 NVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  15 SSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEA-TTPDNMAALLEFMYKGE 93
Cdd:cd18215    3 ASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPeIEPEGFRILLDFMYTSR 82

                         90       100
                 ....*....|....*....|
gi 320544409  94 VHVSQEALNSFLKSAESLQV 113
Cdd:cd18215   83 LNLREGNIMAVMATAMYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  27 KSDLLADVILSCDGVVFKAHKLILAACSKKFADLFEN-TPTNGQCVII-LEATTPDNMAALLEFMYKGEVHVSQEALNSF 104
Cdd:cd18293   11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSePPPAGQKVVLeLQGLKAHTLLKLVDFLYTSELEVSSEEAQDV 90

                         90       100
                 ....*....|....*....|....*
gi 320544409 105 LKSAESLQV---KGLSTETGRLAAQ 126
Cdd:cd18293   91 LAAARRLQIselESLCLEGGKLVKA 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  23 SNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENtPTNGQCVIIlEATTPDNMAALLEFMYKGEVHVSQEALN 102
Cdd:cd18218   10 ARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN-PNPGQWCLG-EGISPSTFKQLLDFVYGESVEVQPGELR 87

                         90       100       110
                 ....*....|....*....|....*....|.
gi 320544409 103 SFLKSAESLQVKGLStetgrlaaQQAQQHMG 133
Cdd:cd18218   88 PLLEAARALEVESLE--------EACWRALG 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  27 KSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNG-QCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFL 105
Cdd:cd18235   17 KQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESrANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLL 96

                 ....*..
gi 320544409 106 KSAESLQ 112
Cdd:cd18235   97 PAANLLQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  27 KSDLLADVILSCDGVVFKAHKLILAACSKKFADLF-ENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFL 105
Cdd:cd18265   19 RSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFgGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVL 98

                         90
                 ....*....|.
gi 320544409 106 KSAESLQVKGL 116
Cdd:cd18265   99 EASDLLQVSKL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409   8 CLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEA-TTPDNMAALL 86
Cdd:cd18331    1 CIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPeINPEGFNILL 80

                         90       100
                 ....*....|....*....|....*..
gi 320544409  87 EFMYKGEVHVSQEALNSFLKSAESLQV 113
Cdd:cd18331   81 DFMYTSRLNLREGNIMAVMATAMYLQM 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  24 NLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVII-LEATTPDNMAALLEFMYKGEVHVSQEALN 102
Cdd:cd18237   14 NMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVeLKDAEPDIIELLVEFAYTARISVNSNNVQ 93

                         90       100
                 ....*....|....*....|....*
gi 320544409 103 SFLKSAESLQVKGLSTETGRLAAQQ 127
Cdd:cd18237   94 SLLDAANQYQIEPVKKMCVDFLKEQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  22 FSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAAL----LEFMYKGEVHVS 97
Cdd:cd18292    8 IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVfekfLRYLYTGQISVN 87

                         90
                 ....*....|....*....
gi 320544409  98 QEALNSFLKSAESLQVKGL 116
Cdd:cd18292   88 LETALPLLMLADKYNVTDL 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  29 DLLADVILSCDGVVFKAHKLILAACSKKFADLFentpTNG-----QCVIILEATTPDNMAALLEFMYKGEVHVSQEALNS 103
Cdd:cd18255   16 GQLLDVTLIADGQRFQAHKVVLASCSDYFRAMF----TGGmressQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQD 91

                         90
                 ....*....|
gi 320544409 104 FLKSAESLQV 113
Cdd:cd18255   92 VLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  28 SDLLADVILSCDGVVFKAHKLILAACSKKFADLFEN-TPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLK 106
Cdd:cd18326   22 QGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSgAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILS 101

                         90
                 ....*....|.
gi 320544409 107 SAESLQVKGLS 117
Cdd:cd18326  102 AARLLEIPAVS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  13 SFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTngqcvIILEAT--TPDNMAALLEFMY 90
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDT-----ISIDASvvSPEEFALLLEMVY 79

                         90       100
                 ....*....|....*....|...
gi 320544409  91 KGEVHVSQEALNSFLKSAESLQV 113
Cdd:cd18225   80 TGKLPPGKHNFTKIISVADSLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  22 FSNLFKSDLLADVILSC-DGVVFKAHKLILAACSKKFADLF-ENTPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQE 99
Cdd:cd18252   12 FRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYFKVMFtADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITER 91

                         90
                 ....*....|...
gi 320544409 100 ALNSFLKSAESLQ 112
Cdd:cd18252   92 NVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  33 DVILSCDGVVFKAHKLILAACSKKFADLF---ENTPTNGQCV-IILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSA 108
Cdd:cd18307    3 DVVISVDNHSFAAHRNVLAAVSPFVKSLIssnDMKATDELSItIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGA 82

                 ....*...
gi 320544409 109 ESLQVKGL 116
Cdd:cd18307   83 KYFNIPRL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  31 LADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNG-QCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAE 109
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREAtEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                 ...
gi 320544409 110 SLQ 112
Cdd:cd18234   81 LLQ 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  28 SDLLADVIL----SCDGVVFKAHKLILAACSKKFADLFentpTNG--QC---VIILEATTPDNMAALLEFMYKGEVHVSQ 98
Cdd:cd18248   18 SQQLCDVTLkvkyQDPKEEFMAHKVVLASSSPYFKAMF----TSGlrECgmeVVPIEGVHPCVMSRLIEFAYTASISVGE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  30 LLADVILSCDGVVFKAHKLILAACSKKFADLFEN-TPTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSA 108
Cdd:cd18264   27 FLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDyTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAA 106

                         90
                 ....*....|....*...
gi 320544409 109 ESLQVkglsTETGRLAAQ 126
Cdd:cd18264  107 SYLQV----TEAIGLCSQ 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  14 FSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFAdlfentPTNGQCVIILEAT--TPDNMAALLEFMYK 91
Cdd:cd18303    1 FISRLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWS------NENLASTNELDLSdiSYEVVLALLRWLYT 74

                         90       100
                 ....*....|....*....|....*...
gi 320544409  92 GEVHVSQ--EALNSFLKSAESLQVKGLS 117
Cdd:cd18303   75 DELDLTLddEFLLELMKAAKRFQLTDLV 102

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320544409  24 NLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIIL-EATTPDNMAALLEFMYKG--EVHV 96
Cdd:cd18295   12 RLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKhPLVNPDAFRALLQYLYTGrlEIHV 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  15 SSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLF--------ENTPTNGQCVIILEATTPDNMAALL 86
Cdd:cd18327    9 SSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFtgggggsgDLGAGGGQDVCELDFVGPEALGALL 88

                         90       100
                 ....*....|....*....|....*..
gi 320544409  87 EFMYKGEVHVSQEALNSFLKSAESLQV 113
Cdd:cd18327   89 EFAYTATLTISSSNMREVLRAARLLEI 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  15 SSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNG-QCVIILEATTPDNMAALLEFMYKGE 93
Cdd:cd18253    2 SESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESrEMLVEINGILAEAMDCFLQYVYTGK 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 320544409  94 VHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQ 127
Cdd:cd18253   82 VKITTENVQYLFETSSLFQISPLRDACAKFLEEQ 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  30 LLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVII-LEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSA 108
Cdd:cd18339   20 LLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIeIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAA 99

                 ....*
gi 320544409 109 ESLQV 113
Cdd:cd18339  100 SLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  24 NLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNG-QCVIILEATTPDNMAALLEFMYKGEVHVSQEALN 102
Cdd:cd18336   12 NYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAkQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIE 91

                         90
                 ....*....|.
gi 320544409 103 SFLKSAESLQV 113
Cdd:cd18336   92 SLLAAACLLQL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  31 LADVILSCDGVVFKAHKLILAACSKKFADLF-----ENTptngQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFL 105
Cdd:cd18238   15 LCDVTLKVGEKSIHCHRLVLACVSPYFRAMFtsemaESK----QDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLL 90

                 ....*...
gi 320544409 106 KSAESLQV 113
Cdd:cd18238   91 YAASLLQV 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544409  12 NSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENT-PTNGQCVIILEATTPDNMAALLEFMY 90
Cdd:cd18236    5 TGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDlKEKYEEKIIIKGVDAETMQILLDYTY 84

                         90       100
                 ....*....|....*....|..
gi 320544409  91 KGEVHVSQEALNSFLKSAESLQ 112
Cdd:cd18236   85 TSKVLITKQNVQRVLEAASLFQ 106