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Conserved domains on  [gi|24581738|ref|NP_723015|]
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mextli, isoform A [Drosophila melanogaster]

Protein Classification

eukaryotic translation initiation factor 4E-binding protein Mextli( domain architecture ID 16910775)

eukaryotic translation initiation factor 4E-binding protein Mextli plays a role in promoting translation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KH-I_Mextli_like cd22454
type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic ...
225-296 5.42e-30

type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic translation initiation factor 4E-binding protein Mextli and similar proteins; Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.


:

Pssm-ID: 411882 [Multi-domain]  Cd Length: 71  Bit Score: 112.79  E-value: 5.42e-30
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24581738 225 KTYCKDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPaEDKINYAKQLMEDTI 296
Cdd:cd22454   1 TGQTTIEVVIPNADVGKVIGKGGETIKRIEALTDTVITFERVNGGSPNREVQITGS-PDNVAAAKRLIEDTI 71
 
Name Accession Description Interval E-value
KH-I_Mextli_like cd22454
type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic ...
225-296 5.42e-30

type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic translation initiation factor 4E-binding protein Mextli and similar proteins; Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.


Pssm-ID: 411882 [Multi-domain]  Cd Length: 71  Bit Score: 112.79  E-value: 5.42e-30
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24581738 225 KTYCKDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPaEDKINYAKQLMEDTI 296
Cdd:cd22454   1 TGQTTIEVVIPNADVGKVIGKGGETIKRIEALTDTVITFERVNGGSPNREVQITGS-PDNVAAAKRLIEDTI 71
KH_1 pfam00013
KH domain; KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause ...
231-294 6.20e-07

KH domain; KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.


Pssm-ID: 459630 [Multi-domain]  Cd Length: 65  Bit Score: 46.89  E-value: 6.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24581738   231 EVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPaEDKINYAKQLMED 294
Cdd:pfam00013   3 EILVPSSLVGLIIGKGGSNIKEIREETGAKIQIPPSESEGNERIVTITGT-PEAVEAAKALIEE 65
KH smart00322
K homology RNA-binding domain;
229-296 1.36e-05

K homology RNA-binding domain;


Pssm-ID: 197652 [Multi-domain]  Cd Length: 68  Bit Score: 43.05  E-value: 1.36e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581738    229 KDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFqrVNPGAKERLVQITGPAEDkINYAKQLMEDTI 296
Cdd:smart00322   4 TIEVLIPADKVGLIIGKGGSTIKKIEEETGVKIDI--PGPGSEERVVEITGPPEN-VEKAAELILEIL 68
 
Name Accession Description Interval E-value
KH-I_Mextli_like cd22454
type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic ...
225-296 5.42e-30

type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic translation initiation factor 4E-binding protein Mextli and similar proteins; Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.


Pssm-ID: 411882 [Multi-domain]  Cd Length: 71  Bit Score: 112.79  E-value: 5.42e-30
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24581738 225 KTYCKDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPaEDKINYAKQLMEDTI 296
Cdd:cd22454   1 TGQTTIEVVIPNADVGKVIGKGGETIKRIEALTDTVITFERVNGGSPNREVQITGS-PDNVAAAKRLIEDTI 71
KH-I cd00105
K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found ...
230-293 2.36e-08

K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that belong to different protein folds, but they share a single KH motif. The KH motif is folded into a beta alpha alpha beta unit. In addition to the core, type II KH domains (e.g. ribosomal protein S3) include an N-terminal extension and type I KH domains (e.g. hnRNP K) contain a C-terminal extension. Some KH-I superfamily members contain a divergent KH domain that lacks the RNA-binding GXXG motif. Some others have a mutated GXXG motif which may or may not have nucleic acid binding ability.


Pssm-ID: 411802 [Multi-domain]  Cd Length: 63  Bit Score: 50.76  E-value: 2.36e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24581738 230 DEVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPAEDkINYAKQLME 293
Cdd:cd00105   1 EEIEVPSELVGLIIGKGGSTIKEIEEETGARIQIPKEGEGSGERVVTITGTPEA-VEKAKELIE 63
KH_1 pfam00013
KH domain; KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause ...
231-294 6.20e-07

KH domain; KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.


Pssm-ID: 459630 [Multi-domain]  Cd Length: 65  Bit Score: 46.89  E-value: 6.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24581738   231 EVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGPaEDKINYAKQLMED 294
Cdd:pfam00013   3 EILVPSSLVGLIIGKGGSNIKEIREETGAKIQIPPSESEGNERIVTITGT-PEAVEAAKALIEE 65
KH-I_HNRNPK_rpt3 cd22434
third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ...
231-299 9.92e-06

third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins; hnRNP K, also called transformation up-regulated nuclear protein (TUNP), is a pre-mRNA binding protein that binds tenaciously to poly(C) sequences. It may be involved in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. It can also bind poly(C) single-stranded DNA. hnRNP K plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. hnRNP K contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one.


Pssm-ID: 411862 [Multi-domain]  Cd Length: 74  Bit Score: 43.85  E-value: 9.92e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24581738 231 EVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRVNPGAKERLVQITGpAEDKINYAKQLMEDTIRRN 299
Cdd:cd22434   5 QVTIPKDLAGSIIGKGGQRIRQIRHESGASIKIDEPLPGSEDRIITITG-TQDQIQNAQYLLQNSVKQY 72
KH smart00322
K homology RNA-binding domain;
229-296 1.36e-05

K homology RNA-binding domain;


Pssm-ID: 197652 [Multi-domain]  Cd Length: 68  Bit Score: 43.05  E-value: 1.36e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581738    229 KDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFqrVNPGAKERLVQITGPAEDkINYAKQLMEDTI 296
Cdd:smart00322   4 TIEVLIPADKVGLIIGKGGSTIKKIEEETGVKIDI--PGPGSEERVVEITGPPEN-VEKAAELILEIL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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