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Conserved domains on  [gi|24582121|ref|NP_723150|]
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uncharacterized protein Dmel_CG9135, isoform B [Drosophila melanogaster]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 119-469 9.54e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 152.05  E-value: 9.54e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 119 VASGpsAAHTILINMDRKALGFGRNPSGQLGLSqDIKLAEKPTIIPALEqlNIVQAAVGRHHTLFLTDTGTVYACGENKS 198
Cdd:COG5184   3 VAAG--GSHSCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 199 GQCGVGNThANIYSPTPINYRGpPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKyfvnanklsfhfETSPKK 278
Cdd:COG5184  78 GQLGDGTT-TDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN------------RLTPVQ 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 279 VVLYIEKskeghvtpvdgvqIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDtqgrGGRSVFC 358
Cdd:COG5184 144 VDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVAA 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 359 GSTFSLIVNELGLLFLFGQNKK----TGEANMYPKPVQDLSGWNITDIGCANTSIM-ISADDTLIAWGASpTFGELGIGE 433
Cdd:COG5184 207 GGDHSCALKSDGTVWCWGSNSSgqlgDGTTTDRATPVQVAGLTGVVAIAAGGSHTCaLKSDGTVWCWGDN-SYGQLGDGT 285

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 24582121 434 fQKSSTVPKEVPKLDNIKipQVTMGYSHT-VLLVDTT 469
Cdd:COG5184 286 -TTDRSTPVKVPGLSGVV--AVAAGSSHTcALLTDGT 319
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 119-469 9.54e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 152.05  E-value: 9.54e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 119 VASGpsAAHTILINMDRKALGFGRNPSGQLGLSqDIKLAEKPTIIPALEqlNIVQAAVGRHHTLFLTDTGTVYACGENKS 198
Cdd:COG5184   3 VAAG--GSHSCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 199 GQCGVGNThANIYSPTPINYRGpPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKyfvnanklsfhfETSPKK 278
Cdd:COG5184  78 GQLGDGTT-TDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN------------RLTPVQ 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 279 VVLYIEKskeghvtpvdgvqIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDtqgrGGRSVFC 358
Cdd:COG5184 144 VDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVAA 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 359 GSTFSLIVNELGLLFLFGQNKK----TGEANMYPKPVQDLSGWNITDIGCANTSIM-ISADDTLIAWGASpTFGELGIGE 433
Cdd:COG5184 207 GGDHSCALKSDGTVWCWGSNSSgqlgDGTTTDRATPVQVAGLTGVVAIAAGGSHTCaLKSDGTVWCWGDN-SYGQLGDGT 285

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 24582121 434 fQKSSTVPKEVPKLDNIKipQVTMGYSHT-VLLVDTT 469
Cdd:COG5184 286 -TTDRSTPVKVPGLSGVV--AVAAGSSHTcALLTDGT 319
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
317-366 8.72e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 51.36  E-value: 8.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 24582121   317 RVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDtqGRGGRSVFCGSTFSLIV 366
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLS--GNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 119-469 9.54e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 152.05  E-value: 9.54e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 119 VASGpsAAHTILINMDRKALGFGRNPSGQLGLSqDIKLAEKPTIIPALEqlNIVQAAVGRHHTLFLTDTGTVYACGENKS 198
Cdd:COG5184   3 VAAG--GSHSCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 199 GQCGVGNThANIYSPTPINYRGpPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKyfvnanklsfhfETSPKK 278
Cdd:COG5184  78 GQLGDGTT-TDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN------------RLTPVQ 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 279 VVLYIEKskeghvtpvdgvqIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDtqgrGGRSVFC 358
Cdd:COG5184 144 VDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVAA 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 359 GSTFSLIVNELGLLFLFGQNKK----TGEANMYPKPVQDLSGWNITDIGCANTSIM-ISADDTLIAWGASpTFGELGIGE 433
Cdd:COG5184 207 GGDHSCALKSDGTVWCWGSNSSgqlgDGTTTDRATPVQVAGLTGVVAIAAGGSHTCaLKSDGTVWCWGDN-SYGQLGDGT 285

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 24582121 434 fQKSSTVPKEVPKLDNIKipQVTMGYSHT-VLLVDTT 469
Cdd:COG5184 286 -TTDRSTPVKVPGLSGVV--AVAAGSSHTcALLTDGT 319
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 172-469 2.80e-34

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 131.64  E-value: 2.80e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 172 VQAAVGRHHTLFLTDTGTVYACGENKSGQCGVGNThANIYSPTPINyRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYG 251
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTT-TDRSTPVRVP-GLSNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 252 QLGHNTDAKyfvnanklsfhfETSPKKvvlyiekskeghVTPVDGVqiVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGH 331
Cdd:COG5184  79 QLGDGTTTD------------RTTPVK------------VPGLTGV--VAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 332 AEPKDEMVPRLMkffDTQGRGGRSVFCGSTFSLIVNELGLLFLFGQNKK------TGEANMYPKPVQDLSGWniTDIGC- 404
Cdd:COG5184 133 GTTTNRLTPVQV---DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYgqlgdgTTTDRPTPVQVGGLSGV--VAVAAg 207

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24582121 405 ANTSIMISADDTLIAWGASpTFGELGIGEFQkSSTVPKEVPKLDNIKipQVTMGYSHT-VLLVDTT 469
Cdd:COG5184 208 GDHSCALKSDGTVWCWGSN-SSGQLGDGTTT-DRATPVQVAGLTGVV--AIAAGGSHTcALKSDGT 269
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 119-340 1.18e-31

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 124.32  E-value: 1.18e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 119 VASGpsAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEkPTIIPALEqlNIVQAAVGRHHTLFLTDTGTVYACGENKS 198
Cdd:COG5184 154 IAAG--GYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPT-PVQVGGLS--GVVAVAAGGDHSCALKSDGTVWCWGSNSS 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 199 GQCGVGNThANIYSPTPINyRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAkyfvnanklsfhFETSPkk 278
Cdd:COG5184 229 GQLGDGTT-TDRATPVQVA-GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTT------------DRSTP-- 292

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24582121 279 vvlyiekskeghvTPVDGV-QIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVP 340
Cdd:COG5184 293 -------------VKVPGLsGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 119-441 1.28e-30

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 121.62  E-value: 1.28e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 119 VASGpsAAHTILINMDRKALGFGRNPSGQLGLSqDIKLAEKPTIIPAlEQLNIVQAAVGRHHTLFLTDTGTVYACGENKS 198
Cdd:COG5184 103 VAAG--YYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDA-GLSGVVAIAAGGYHTCALKSDGTVWCWGANSY 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 199 GQCGVGNThANIYSPTPINYRGpPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKyfvnanklsfhfETSPKK 278
Cdd:COG5184 179 GQLGDGTT-TDRPTPVQVGGLS-GVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTD------------RATPVQ 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 279 VvlyiekskeghvtpVDGVQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAepkdemvprlmkffdtqgrggrsvfc 358
Cdd:COG5184 245 V--------------AGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-------------------------- 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 359 gstfslivnelgllflfgqnkkTGEANMYPKPVQDLSGWniTDIGC-ANTSIMISADDTLIAWGASpTFGELGIGEFqKS 437
Cdd:COG5184 285 ----------------------TTTDRSTPVKVPGLSGV--VAVAAgSSHTCALLTDGTVWCWGDN-AYGQLGDGTT-TD 338


                ....
gi 24582121 438 STVP 441
Cdd:COG5184 339 RSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 119-214 6.31e-12

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 66.92  E-value: 6.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582121 119 VASGPSaaHTILINMDRKALGFGRNPSGQLGLSqDIKLAEKPTIIPALEqlNIVQAAVGRHHTLFLTDTGTVYACGENKS 198
Cdd:COG5184 254 IAAGGS--HTCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVKVPGLS--GVVAVAAGSSHTCALLTDGTVWCWGDNAY 328

                        90
                ....*....|....*.
gi 24582121 199 GQCGVGNThANIYSPT 214
Cdd:COG5184 329 GQLGDGTT-TDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
317-366 8.72e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 51.36  E-value: 8.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 24582121   317 RVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDtqGRGGRSVFCGSTFSLIV 366
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLS--GNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
188-236 2.56e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.82  E-value: 2.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 24582121   188 GTVYACGENKSGQCGVGNTHaNIYSPTPINY-RGPPIIRIGCGAEFSVIL 236
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGlSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
171-200 3.76e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.96  E-value: 3.76e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 24582121   171 IVQAAVGRHHTLFLTDTGTVYACGENKSGQ 200
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
239-312 1.06e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 1.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24582121   239 KGSLHTFGLPEYGQLGHNTDAKYFVnanklsfhfetsPKKvvlyiekskeghVTPVDGVQIVDFACGNNHTVAI 312
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLV------------PQK------------VEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
139-184 1.77e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 1.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 24582121   139 GFGRNPSGQLGLsQDIKLAEKPTIIPALEQLNIVQAAVGRHHTLFL 184
Cdd:pfam00415   6 TWGRNDYGQLGL-GTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
299-328 2.12e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 2.12e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 24582121   299 IVDFACGNNHTVAIDSKKRVYSWGFGGFGR 328
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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