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Conserved domains on  [gi|24583633|ref|NP_723654|]
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Ge-1, isoform B [Drosophila melanogaster]

Protein Classification

Ge1_WD40 and PHA03247 domain-containing protein( domain architecture ID 12178812)

Ge1_WD40 and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 119-452 0e+00

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


:

Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 565.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    119 GSSKVKLKNIVDYKWERKYYYpGHLVAVHRDGKHLAYAINVNNkatgMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHT 198
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYP-GQLVAVHRDGKYLAYAIKVKN----GGGMVRVINIETSERALLKGMTGEVLDLAFAHT 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    199 DCERILAVIDVSSLFVYKVDQIEGNLLCNLVLKVEDPIANYVPEYDMVSWCPYVCSSSATvpINDDDDENQLLIWSRSSQ 278
Cdd:pfam16529   76 DCVILACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDET--ESDDDDESKLLVLLRGDK 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    279 FQCFQVKMIVSEHGRGKIQPAALESGYLKIEEDSLITCAALSPDGTTVAAACADGLVRFYQIYLFDVRNHRCLHEWKPHD 358
Cdd:pfam16529  154 AEIWNVDMIVSEHGSGPLQPAALESGYIEIEEHSLLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHD 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    359 GKKVCSLFFLDNINKPVEESYWQHVITTSDANTEIKLWNCSLWKCLQTINVVAS-PSSLQPRNFIAGIDRSANYLVLSCL 437
Cdd:pfam16529  234 GKPLSSLFFLDNHKKPPEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDpPSSLQPPNLKAGLDLSANYLVLSDL 313

                          330
                   ....*....|....*
gi 24583633    438 DSLAVYVMQIGSTGG 452
Cdd:pfam16529  314 DNKVLYVLQLGQDGE 328
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 893-1063 5.87e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    893 ELNAKMELLIDLVKAQSKQINKLENEVNKLQKQQEAAAALHSKqdTSLEPKNLSQLAYKIEMQLSKLMEQ------YLKR 966
Cdd:TIGR04523  100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDK--FLTEIKKKEKELEKLNNKYNDLKKQkeelenELNL 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    967 YENEHKKKLTEFLAARESQNR-ELRDSVLQVLNQyvmnhftdiignvLNMELQRQL--LPRVNANMDQLQAQMQVEIVQK 1043
Cdd:TIGR04523  178 LEKEKLNIQKNIDKIKNKLLKlELLLSNLKKKIQ-------------KNKSLESQIseLKKQNNQLKDNIEKKQQEINEK 244

                          170       180
                   ....*....|....*....|
gi 24583633   1044 LSVFdKTVKENIAQVcKSKQ 1063
Cdd:TIGR04523  245 TTEI-SNTQTQLNQL-KDEQ 262
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 119-452 0e+00

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 565.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    119 GSSKVKLKNIVDYKWERKYYYpGHLVAVHRDGKHLAYAINVNNkatgMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHT 198
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYP-GQLVAVHRDGKYLAYAIKVKN----GGGMVRVINIETSERALLKGMTGEVLDLAFAHT 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    199 DCERILAVIDVSSLFVYKVDQIEGNLLCNLVLKVEDPIANYVPEYDMVSWCPYVCSSSATvpINDDDDENQLLIWSRSSQ 278
Cdd:pfam16529   76 DCVILACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDET--ESDDDDESKLLVLLRGDK 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    279 FQCFQVKMIVSEHGRGKIQPAALESGYLKIEEDSLITCAALSPDGTTVAAACADGLVRFYQIYLFDVRNHRCLHEWKPHD 358
Cdd:pfam16529  154 AEIWNVDMIVSEHGSGPLQPAALESGYIEIEEHSLLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHD 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    359 GKKVCSLFFLDNINKPVEESYWQHVITTSDANTEIKLWNCSLWKCLQTINVVAS-PSSLQPRNFIAGIDRSANYLVLSCL 437
Cdd:pfam16529  234 GKPLSSLFFLDNHKKPPEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDpPSSLQPPNLKAGLDLSANYLVLSDL 313

                          330
                   ....*....|....*
gi 24583633    438 DSLAVYVMQIGSTGG 452
Cdd:pfam16529  314 DNKVLYVLQLGQDGE 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-444 7.99e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 7.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRFYqiylfDVRNHRCLHEWKPHDGkKVCSLFFLDNINkpveesywqHVITTSDANTeI 393
Cdd:cd00200  138 VNSVAFSPDGTFVASSSQDGTIKLW-----DLRTGKCVATLTGHTG-EVNSVAFSPDGE---------KLLSSSSDGT-I 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24583633  394 KLWNCSLWKCLQTINVvaspsslqPRNFIAGIDRSAN-YLVLSCLDSLAVYV 444
Cdd:cd00200  202 KLWDLSTGKCLGTLRG--------HENGVNSVAFSPDgYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
311-408 1.98e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  311 DSLITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSLFFL-DNinkpveesywQHVITTSDA 389
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVR-----LWDLATGELLRTLTGHSG-GVNSVAFSpDG----------KLLASGSDD 309

                         90
                 ....*....|....*....
gi 24583633  390 NTeIKLWNCSLWKCLQTIN 408
Cdd:COG2319  310 GT-VRLWDLATGKLLRTLT 327
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 893-1063 5.87e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    893 ELNAKMELLIDLVKAQSKQINKLENEVNKLQKQQEAAAALHSKqdTSLEPKNLSQLAYKIEMQLSKLMEQ------YLKR 966
Cdd:TIGR04523  100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDK--FLTEIKKKEKELEKLNNKYNDLKKQkeelenELNL 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    967 YENEHKKKLTEFLAARESQNR-ELRDSVLQVLNQyvmnhftdiignvLNMELQRQL--LPRVNANMDQLQAQMQVEIVQK 1043
Cdd:TIGR04523  178 LEKEKLNIQKNIDKIKNKLLKlELLLSNLKKKIQ-------------KNKSLESQIseLKKQNNQLKDNIEKKQQEINEK 244

                          170       180
                   ....*....|....*....|
gi 24583633   1044 LSVFdKTVKENIAQVcKSKQ 1063
Cdd:TIGR04523  245 TTEI-SNTQTQLNQL-KDEQ 262
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 119-452 0e+00

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 565.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    119 GSSKVKLKNIVDYKWERKYYYpGHLVAVHRDGKHLAYAINVNNkatgMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHT 198
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYP-GQLVAVHRDGKYLAYAIKVKN----GGGMVRVINIETSERALLKGMTGEVLDLAFAHT 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    199 DCERILAVIDVSSLFVYKVDQIEGNLLCNLVLKVEDPIANYVPEYDMVSWCPYVCSSSATvpINDDDDENQLLIWSRSSQ 278
Cdd:pfam16529   76 DCVILACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDET--ESDDDDESKLLVLLRGDK 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    279 FQCFQVKMIVSEHGRGKIQPAALESGYLKIEEDSLITCAALSPDGTTVAAACADGLVRFYQIYLFDVRNHRCLHEWKPHD 358
Cdd:pfam16529  154 AEIWNVDMIVSEHGSGPLQPAALESGYIEIEEHSLLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHD 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    359 GKKVCSLFFLDNINKPVEESYWQHVITTSDANTEIKLWNCSLWKCLQTINVVAS-PSSLQPRNFIAGIDRSANYLVLSCL 437
Cdd:pfam16529  234 GKPLSSLFFLDNHKKPPEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDpPSSLQPPNLKAGLDLSANYLVLSDL 313

                          330
                   ....*....|....*
gi 24583633    438 DSLAVYVMQIGSTGG 452
Cdd:pfam16529  314 DNKVLYVLQLGQDGE 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-444 7.99e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 7.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRFYqiylfDVRNHRCLHEWKPHDGkKVCSLFFLDNINkpveesywqHVITTSDANTeI 393
Cdd:cd00200  138 VNSVAFSPDGTFVASSSQDGTIKLW-----DLRTGKCVATLTGHTG-EVNSVAFSPDGE---------KLLSSSSDGT-I 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24583633  394 KLWNCSLWKCLQTINVvaspsslqPRNFIAGIDRSAN-YLVLSCLDSLAVYV 444
Cdd:cd00200  202 KLWDLSTGKCLGTLRG--------HENGVNSVAFSPDgYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
311-408 1.98e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  311 DSLITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSLFFL-DNinkpveesywQHVITTSDA 389
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVR-----LWDLATGELLRTLTGHSG-GVNSVAFSpDG----------KLLASGSDD 309

                         90
                 ....*....|....*....
gi 24583633  390 NTeIKLWNCSLWKCLQTIN 408
Cdd:COG2319  310 GT-VRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
314-408 3.89e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSL-FFLDNinkpveesywQHVITTSDANTe 392
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGTVR-----LWDLATGKLLRTLTGHSG-AVTSVaFSPDG----------KLLASGSDDGT- 185

                         90
                 ....*....|....*.
gi 24583633  393 IKLWNCSLWKCLQTIN 408
Cdd:COG2319  186 VRLWDLATGKLLRTLT 201
WD40 COG2319
WD40 repeat [General function prediction only];
314-407 1.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSL-FFLDNinkpveesywQHVITTSDANTe 392
Cdd:COG2319  291 VNSVAFSPDGKLLASGSDDGTVR-----LWDLATGKLLRTLTGHTG-AVRSVaFSPDG----------KTLASGSDDGT- 353

                         90
                 ....*....|....*
gi 24583633  393 IKLWNCSLWKCLQTI 407
Cdd:COG2319  354 VRLWDLATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
314-407 2.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 2.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSLFFL-DNinkpveesywQHVITTSDANTe 392
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVR-----LWDLATGKLLRTLTGHSG-SVRSVAFSpDG----------RLLASGSADGT- 269

                         90
                 ....*....|....*
gi 24583633  393 IKLWNCSLWKCLQTI 407
Cdd:COG2319  270 VRLWDLATGELLRTL 284
WD40 COG2319
WD40 repeat [General function prediction only];
314-408 2.56e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSL-FFLDNinkpveesywQHVITTSDANTe 392
Cdd:COG2319  165 VTSVAFSPDGKLLASGSDDGTVR-----LWDLATGKLLRTLTGHTG-AVRSVaFSPDG----------KLLASGSADGT- 227

                         90
                 ....*....|....*.
gi 24583633  393 IKLWNCSLWKCLQTIN 408
Cdd:COG2319  228 VRLWDLATGKLLRTLT 243
WD40 COG2319
WD40 repeat [General function prediction only];
144-397 6.95e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 6.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  144 VAVHRDGKHLAYAinvnnkatGMEGMVRVCNIAT-SMRALIKGMSGEVLDLQFAHtDCERILAVIDVSSLFVYKVDqiEG 222
Cdd:COG2319  210 VAFSPDGKLLASG--------SADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA--TG 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  223 NLLCNLVLKVEDPIAnyvpeydmVSWCP---YVCSSSatvpindddDENQLLIWSRSSQfQCFQVkmiVSEHGRGkiqpa 299
Cdd:COG2319  279 ELLRTLTGHSGGVNS--------VAFSPdgkLLASGS---------DDGTVRLWDLATG-KLLRT---LTGHTGA----- 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  300 alesgylkieedslITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSLFFL-DNinkpvees 378
Cdd:COG2319  333 --------------VRSVAFSPDGKTLASGSDDGTVR-----LWDLATGELLRTLTGHTG-AVTSVAFSpDG-------- 384

                        250
                 ....*....|....*....
gi 24583633  379 ywQHVITTSDANTeIKLWN 397
Cdd:COG2319  385 --RTLASGSADGT-VRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-408 6.57e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 6.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDgKKVCSLFFLDNinkpveesywQHVITTSDANTEI 393
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIR-----LWDLETGECVRTLTGHT-SYVSSVAFSPD----------GRILSSSSRDKTI 117

                         90
                 ....*....|....*
gi 24583633  394 KLWNCSLWKCLQTIN 408
Cdd:cd00200  118 KVWDVETGKCLTTLR 132
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-407 2.72e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGlvrfyQIYLFDVRNHRCLHEWKPHDgKKVCSLFFLDNinkpveeSYWqhvITTSDANTEI 393
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDG-----TIKLWDLSTGKCLGTLRGHE-NGVNSVAFSPD-------GYL---LASGSEDGTI 243

                         90
                 ....*....|....
gi 24583633  394 KLWNCSLWKCLQTI 407
Cdd:cd00200  244 RVWDLRTGECVQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 104-339 3.13e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  104 SNKTKVLTSGGVHtrgsSKVKLKNIVDYKweRKYYYPGHL-----VAVHRDGKHLAYAinvnnkatGMEGMVRVCNIAT- 177
Cdd:cd00200  102 SPDGRILSSSSRD----KTIKVWDVETGK--CLTTLRGHTdwvnsVAFSPDGTFVASS--------SQDGTIKLWDLRTg 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  178 SMRALIKGMSGEVLDLQFaHTDCERILAVIDVSSLFVYkvDQIEGNLLCNLVLKvEDPIANyvpeydmVSWCP---YVCS 254
Cdd:cd00200  168 KCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGH-ENGVNS-------VAFSPdgyLLAS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  255 SSatvpindddDENQLLIWSRSSqfqcFQVKMIVSEHgrgkiqpaalesgylkieeDSLITCAALSPDGTTVAAACADGL 334
Cdd:cd00200  237 GS---------EDGTIRVWDLRT----GECVQTLSGH-------------------TNSVTSLAWSPDGKRLASGSADGT 284


                 ....*
gi 24583633  335 VRFYQ 339
Cdd:cd00200  285 IRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 309-363 4.69e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 4.69e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 24583633    309 EEDSLITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGKKVC 363
Cdd:pfam12894   36 KEDLEVTSLAWRPDGKLLAVGYSDGTVR-----LLDAENGKIVHHFSAGSDLITC 85
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-407 6.74e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 6.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  314 ITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGKkVCSLFFLDNinkpveesywQHVITTSDANTEI 393
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRDKTIK-----VWDVETGKCLTTLRGHTDW-VNSVAFSPD----------GTFVASSSQDGTI 159

                         90
                 ....*....|....
gi 24583633  394 KLWNCSLWKCLQTI 407
Cdd:cd00200  160 KLWDLRTGKCVATL 173
WD40 COG2319
WD40 repeat [General function prediction only];
311-408 2.35e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633  311 DSLITCAALSPDGTTVAAACADGLVRfyqiyLFDVRNHRCLHEWKPHDGkKVCSLFFL-DNinkpveesywQHVITTSDA 389
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVR-----LWDLATGLLLRTLTGHTG-AVRSVAFSpDG----------KTLASGSAD 141

                         90
                 ....*....|....*....
gi 24583633  390 NTeIKLWNCSLWKCLQTIN 408
Cdd:COG2319  142 GT-VRLWDLATGKLLRTLT 159
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 893-1063 5.87e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    893 ELNAKMELLIDLVKAQSKQINKLENEVNKLQKQQEAAAALHSKqdTSLEPKNLSQLAYKIEMQLSKLMEQ------YLKR 966
Cdd:TIGR04523  100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDK--FLTEIKKKEKELEKLNNKYNDLKKQkeelenELNL 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583633    967 YENEHKKKLTEFLAARESQNR-ELRDSVLQVLNQyvmnhftdiignvLNMELQRQL--LPRVNANMDQLQAQMQVEIVQK 1043
Cdd:TIGR04523  178 LEKEKLNIQKNIDKIKNKLLKlELLLSNLKKKIQ-------------KNKSLESQIseLKKQNNQLKDNIEKKQQEINEK 244

                          170       180
                   ....*....|....*....|
gi 24583633   1044 LSVFdKTVKENIAQVcKSKQ 1063
Cdd:TIGR04523  245 TTEI-SNTQTQLNQL-KDEQ 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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