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Conserved domains on  [gi|24584456|ref|NP_723916|]
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odorant receptor 35a [Drosophila melanogaster]

Protein Classification

odorant receptor( domain architecture ID 139944)

odorant receptor (OR) found in insects similar to Drosophila ORs, novel seven-transmembrane domain proteins that can signal independently of heterotrimeric G proteins, and which show no obvious sequence homology with G protein-coupled receptors (GPCRs) and display an inverted topology with an intracellular N-terminus and an extracellular C-terminus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_6 super family cl20237
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 74-393 4.98e-07

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


The actual alignment was detected with superfamily member pfam02949:

Pssm-ID: 251636  Cd Length: 313  Bit Score: 51.13  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456    74 NLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFyANIYIDPRKEPEMFRKVD---GKMIINRLVSAMYGAVISL 150
Cdd:pfam02949   1 NLTEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLL-RELDPRCLEEEEERIFERlvaTASRVRFLLFIIYILAYAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   151 YLIAPVFSII---NQSKDFLYSMIFPFDSDPL-YIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDlq 226
Cdd:pfam02949  80 FCISALVSMVlslERGLPLPYYLPFPFDWEASrPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHLRLLQLR-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   227 laIEKILvaRDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFK--AYTNPMANYIYAI 304
Cdd:pfam02949 158 --LERLG--LDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNllFFSGPLQGIYYVL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   305 WFGAKTVELLSLGQIGSDLAFTTDSLSTMYYLTHWeqilqystnPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQA 384
Cdd:pfam02949 234 YLLAMLIQLFPYCYYGNELTEASEELANAIYSSNW---------YDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPT 304


                  ....*....
gi 24584456   385 GLKILQASF 393
Cdd:pfam02949 305 FISILKFAY 313
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 74-393 4.98e-07

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 51.13  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456    74 NLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFyANIYIDPRKEPEMFRKVD---GKMIINRLVSAMYGAVISL 150
Cdd:pfam02949   1 NLTEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLL-RELDPRCLEEEEERIFERlvaTASRVRFLLFIIYILAYAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   151 YLIAPVFSII---NQSKDFLYSMIFPFDSDPL-YIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDlq 226
Cdd:pfam02949  80 FCISALVSMVlslERGLPLPYYLPFPFDWEASrPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHLRLLQLR-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   227 laIEKILvaRDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFK--AYTNPMANYIYAI 304
Cdd:pfam02949 158 --LERLG--LDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNllFFSGPLQGIYYVL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   305 WFGAKTVELLSLGQIGSDLAFTTDSLSTMYYLTHWeqilqystnPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQA 384
Cdd:pfam02949 234 YLLAMLIQLFPYCYYGNELTEASEELANAIYSSNW---------YDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPT 304


                  ....*....
gi 24584456   385 GLKILQASF 393
Cdd:pfam02949 305 FISILKFAY 313
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 74-393 4.98e-07

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 51.13  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456    74 NLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFyANIYIDPRKEPEMFRKVD---GKMIINRLVSAMYGAVISL 150
Cdd:pfam02949   1 NLTEALTNLQVLVTSIVCLFKFLLILLKRKEIVELISLL-RELDPRCLEEEEERIFERlvaTASRVRFLLFIIYILAYAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   151 YLIAPVFSII---NQSKDFLYSMIFPFDSDPL-YIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDlq 226
Cdd:pfam02949  80 FCISALVSMVlslERGLPLPYYLPFPFDWEASrPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHLRLLQLR-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   227 laIEKILvaRDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFK--AYTNPMANYIYAI 304
Cdd:pfam02949 158 --LERLG--LDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNllFFSGPLQGIYYVL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584456   305 WFGAKTVELLSLGQIGSDLAFTTDSLSTMYYLTHWeqilqystnPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQA 384
Cdd:pfam02949 234 YLLAMLIQLFPYCYYGNELTEASEELANAIYSSNW---------YDASRRYRRTLLIFIMRAQRPITIKAGGFFPISLPT 304


                  ....*....
gi 24584456   385 GLKILQASF 393
Cdd:pfam02949 305 FISILKFAY 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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