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Conserved domains on  [gi|28574245|ref|NP_724047|]
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cytoplasmic linker protein 190, isoform B [Drosophila melanogaster]

Protein Classification

kinesin family protein; PEPP family PH domain-containing protein( domain architecture ID 13652248)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has ATPase-containing motor domain; similar to carboxy-terminal kinesins that contains a C-terminal domain responsible for the motor activity (it hydrolyzes ATP and binds microtubules)| PEPP (phosphoinositol 3-phosphate-binding protein) family PH (pleckstrin homology) domain-containing protein similar to PH domain region of vertebrate pleckstrin homology domain-containing family A member 4/5/6/7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 239-306 9.93e-34

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


:

Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 124.44  E-value: 9.93e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245    239 VGDRVIVSsgfGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 306
Cdd:pfam01302    1 VGDRVEVP---GGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 125-189 6.43e-30

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


:

Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 113.27  E-value: 6.43e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245    125 IGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRL 189
Cdd:pfam01302    1 VGDRVEVPGGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 637-1490 1.66e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 128.64  E-value: 1.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    637 LDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEklvrem 716
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------ 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    717 tenaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 796
Cdd:TIGR02168  269 ----LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    797 ALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQ 873
Cdd:TIGR02168  345 KLEELKEELESLeaeLEELEAELEELESRLEELEEQL------------------ETLRSKVAQLELQIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    874 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 953
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELLKKLEEAELKE--LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    954 AESRA----------EASDLQDKVKE----------ITDTLHAELQAERSSSSALHTKLSKFSDEIATghkelTSKADAW 1013
Cdd:TIGR02168  485 AQLQArldslerlqeNLEGFSEGVKAllknqsglsgILGVLSELISVDEGYEAAIEAALGGRLQAVVV-----ENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1014 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEVTKAKTeNLELSTGTQTTIKDLQERLEIT 1091
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKniEGFLGVAKDLVKFDPKLRK-ALSYLLGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1092 NaELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELstvlevlqaeksetnhifelfemeadmnsERLIEKVTG 1171
Cdd:TIGR02168  639 K-KLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREI-----------------------------EELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1172 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSS 1251
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1252 IIEAQNTKLNESNVQLENKTSCLKETQDQ-------LLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1324
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEElkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1325 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:TIGR02168  849 ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1405 TVLESQKKSHNEIQDKL--------EQAQQKERTLQEETSKLAEQLSQLKQ-----------ANEELQKSLQQKQLLLEK 1465
Cdd:TIGR02168  929 LRLEGLEVRIDNLQERLseeysltlEEAEALENKIEDDEEEARRRLKRLENkikelgpvnlaAIEEYEELKERYDFLTAQ 1008

                          890       900
                   ....*....|....*....|....*
gi 28574245   1466 GNEFDTQLAEYQKVIDEMDDAASVK 1490
Cdd:TIGR02168 1009 KEDLTEAKETLEEAIEEIDREARER 1033
NIP100 super family cl34954
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 237-814 2.93e-11

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG5244:

Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 68.56  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  237 MAVGDRVIVSSGFGsrpgILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV--------------- 301
Cdd:COG5244    4 LSVNDRVLLGDKFG----TVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIrpdddsllngnaaye 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  302 --------------PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTA---TSRMRMN------AQRKSSTPVKPI 358
Cdd:COG5244   80 kikgglvceskgmdKDGEIKQENHEDRIHFEESKIRRLEETIEALKSTEKEEiveLRRENEEldkinlSLRERISSEEPE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  359 LATPKSQFSMQDL--LREKQQHVEKLMVERDLDREDAQNQALQLQKNI--NELKARIVE--------LESALDNERKKTE 426
Cdd:COG5244  160 LNKDGSKLSYDELkeFVEESRVQVYDMVELVSDISETLNRNGSIQRSSvrECERSNIHDvlflvngiLDGVIDELNGELE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  427 ELQ---CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQkeV 503
Cdd:COG5244  240 RLRrqlVSLMSSHGIEVEENSRLKATLEKFQSLELKVNTL--QEELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEV--I 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  504 ESRIAEQLEeeqrlrenvkylNEQIATLQSELVSKDEALEKFSLSECgiENLRRELELLKEENEKQAQEAQAEFTRKLAE 583
Cdd:COG5244  316 ESENFGKLE------------NIEIHIILKVLSSISYALHIYTIKNT--PDHLETTLQCFVNIAPISMWLSEFLQRKFSS 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  584 KSVEVLrlsSELQNLKATSDSLE----------------------SERVNKTDECEILQTEVRMRdeQIRELNQQlDEVT 641
Cdd:COG5244  382 KQETAF---SICQFLEDNKDVTLilkilhpilettvpkllaflrtNSNFNDNDTLCLIGSLYEIA--RIDKLIGK-EEIS 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  642 TQLN----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 717
Cdd:COG5244  456 KQDNrlflYPSCDITLSSILTILFSDKLEVFFQGIESLLENITIFPEQPSQQTSDSENIKENSLLSDRLNEENIRLKEVL 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  718 ENAINQIQLEKESieQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE---KL 794
Cdd:COG5244  536 VQKENMLTEETKI--KIIIGRDLERKTLEENIKTLKVELNNKNNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKiylDL 613

                        650       660
                 ....*....|....*....|
gi 28574245  795 QAALEELKKEKETIIKEKEQ 814
Cdd:COG5244  614 VSEIMELRETIRRQIKEQKR 633
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1667-1683 1.30e-06

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


:

Pssm-ID: 465212  Cd Length: 17  Bit Score: 45.92  E-value: 1.30e-06
                           10
                   ....*....|....*..
gi 28574245   1667 RKYCDSCEVFGHDTSEC 1683
Cdd:pfam16641    1 RPYCEICEVFGHDTEDC 17
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1620-1637 9.53e-05

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


:

Pssm-ID: 465212  Cd Length: 17  Bit Score: 40.91  E-value: 9.53e-05
                           10
                   ....*....|....*...
gi 28574245   1620 RLFCDICDEFDqHDTEDC 1637
Cdd:pfam16641    1 RPYCEICEVFG-HDTEDC 17
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1428-1597 4.22e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1428 ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL---EKGNEFDTQLAEYQkVIDEMDDAASV--KSALLEQLQNRVA 1502
Cdd:COG4913  220 EPDTFEAADALVEHFDDLERAHEALEDAREQIELLEpirELAERYAAARERLA-ELEYLRAALRLwfAQRRLELLEAELE 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1503 ELETALRQANDAQKtayletkELRRQLESLEleksREVLSLKAQMNGASsrsgkGDEVESLDietslAKINFLNSIIADM 1582
Cdd:COG4913  299 ELRAELARLEAELE-------RLEARLDALR----EELDELEAQIRGNG-----GDRLEQLE-----REIERLERELEER 357

                        170
                 ....*....|....*
gi 28574245 1583 QQKNDALKAKVQTLE 1597
Cdd:COG4913  358 ERRRARLEALLAALG 372
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 2-118 1.47e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245     2 SDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPqpskmkAPSSFGSTGSVSKIGRPCCNHTTP 81
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST------SSSSESSRGAAVSPGPSPSRSPSP 353

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 28574245    82 KSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTA 118
Cdd:PHA03307  354 SRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRA 390
 
Name Accession Description Interval E-value
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 239-306 9.93e-34

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 124.44  E-value: 9.93e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245    239 VGDRVIVSsgfGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 306
Cdd:pfam01302    1 VGDRVEVP---GGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 125-189 6.43e-30

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 113.27  E-value: 6.43e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245    125 IGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRL 189
Cdd:pfam01302    1 VGDRVEVPGGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 637-1490 1.66e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 128.64  E-value: 1.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    637 LDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEklvrem 716
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------ 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    717 tenaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 796
Cdd:TIGR02168  269 ----LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    797 ALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQ 873
Cdd:TIGR02168  345 KLEELKEELESLeaeLEELEAELEELESRLEELEEQL------------------ETLRSKVAQLELQIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    874 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 953
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELLKKLEEAELKE--LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    954 AESRA----------EASDLQDKVKE----------ITDTLHAELQAERSSSSALHTKLSKFSDEIATghkelTSKADAW 1013
Cdd:TIGR02168  485 AQLQArldslerlqeNLEGFSEGVKAllknqsglsgILGVLSELISVDEGYEAAIEAALGGRLQAVVV-----ENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1014 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEVTKAKTeNLELSTGTQTTIKDLQERLEIT 1091
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKniEGFLGVAKDLVKFDPKLRK-ALSYLLGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1092 NaELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELstvlevlqaeksetnhifelfemeadmnsERLIEKVTG 1171
Cdd:TIGR02168  639 K-KLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREI-----------------------------EELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1172 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSS 1251
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1252 IIEAQNTKLNESNVQLENKTSCLKETQDQ-------LLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1324
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEElkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1325 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:TIGR02168  849 ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1405 TVLESQKKSHNEIQDKL--------EQAQQKERTLQEETSKLAEQLSQLKQ-----------ANEELQKSLQQKQLLLEK 1465
Cdd:TIGR02168  929 LRLEGLEVRIDNLQERLseeysltlEEAEALENKIEDDEEEARRRLKRLENkikelgpvnlaAIEEYEELKERYDFLTAQ 1008

                          890       900
                   ....*....|....*....|....*
gi 28574245   1466 GNEFDTQLAEYQKVIDEMDDAASVK 1490
Cdd:TIGR02168 1009 KEDLTEAKETLEEAIEEIDREARER 1033
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 239-307 2.68e-29

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 111.91  E-value: 2.68e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245     239 VGDRVIVSSGfgSRPGILRYLGETQFAPGNWCGVELDEP-SGKNDGTVDDIRYFECKPKYGVFVPIAKVS 307
Cdd:smart01052    1 VGDRVEVGGG--GRRGTVRYVGPTPFAPGVWVGVELDEPlRGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1518 3.30e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.72  E-value: 3.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1167 EKVTGIKEELKETHLQL-----DERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQN 1241
Cdd:COG1196  213 ERYRELKEELKELEAELlllklRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1242 LEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1321
Cdd:COG1196  293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1322 LVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLD 1401
Cdd:COG1196  373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1402 ESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVID 1481
Cdd:COG1196  453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 28574245 1482 EMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1518
Cdd:COG1196  533 EAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAA 569
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 125-190 3.47e-23

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 94.19  E-value: 3.47e-23
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245     125 IGQRVWLGGT-RPGQIAFIGDTHFAAGEWAGVVLDEPN-GKNDGCVSGKRYFQCEPKRGIFSRLTRLT 190
Cdd:smart01052    1 VGDRVEVGGGgRRGTVRYVGPTPFAPGVWVGVELDEPLrGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 666-1539 4.10e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 94.65  E-value: 4.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    666 EEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLA--EQEKLVREMTENAINQIQLEKESIEQQLALKQNELE 743
Cdd:pfam02463  186 AELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLylDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    744 DFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKeketiikeKEQELQQLQSKS 823
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK--------AEKELKKEKEEI 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    824 AESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 903
Cdd:pfam02463  338 EELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    904 SGHLLEQITKLKSEVGETQaalsschTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERS 983
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEE-------ESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    984 SSSALHTKLSKFSDEIATGHKELTSKADawsqemlqkekelqelrqqlqdsqDSQTKLKAEGERKEKSFEESIKNLQEEV 1063
Cdd:pfam02463  491 SRQKLEERSQKESKARSGLKVLLALIKD------------------------GVGGRIISAHGRLGDLGVAVENYKVAIS 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1064 TKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAE 1143
Cdd:pfam02463  547 TAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVE 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1144 KSETNHIFELFEMEADMNSERLIEKVTGIKEElkethLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQ 1223
Cdd:pfam02463  627 GILKDTELTKLKESAKAKESGLRKGVSLEEGL-----AEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1224 SLQELqdsvKQKEELVQNLEEKVResssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQ 1303
Cdd:pfam02463  702 KKKEQ----REKEELKKLKLEAEE-----LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1304 QVQEANGDIKDSLVKVEELvkvLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELK 1383
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEE---KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1384 EALCQKENGLKELQGKLDESNtvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL 1463
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQ--ELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA 927

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   1464 EKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSRE 1539
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE 1003
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
890-1512 1.60e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 92.41  E-value: 1.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   890 LEAANGSLEE-----EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEkvnkEYAESRAEASDLQ 964
Cdd:PRK02224  182 LSDQRGSLDQlkaqiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLE----EHEERREELETLE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   965 DKVKEITDTLhAELQAERSS-SSALHTK---LSKFSDEIA-----TGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ 1035
Cdd:PRK02224  258 AEIEDLRETI-AETEREREElAEEVRDLrerLEELEEERDdllaeAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1036 DSQTKLKAEGERkeksfeESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEitnaelqhkekmasedaqKIADLKTL 1115
Cdd:PRK02224  337 AQAHNEEAESLR------EDADDLEERAEELREEAAELESELEEAREAVEDRRE------------------EIEELEEE 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1116 VEAIQVANANISATNAELSTVLEVLQAEKSETNHifELFEMEADMNSER-LIEKVTGIKEELK----------ETHLQ-L 1183
Cdd:PRK02224  393 IEELRERFGDAPVDLGNAEDFLEELREERDELRE--REAELEATLRTAReRVEEAEALLEAGKcpecgqpvegSPHVEtI 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1184 DERQKKFEELEEKLKQAQqseqklqqESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNEs 1263
Cdd:PRK02224  471 EEDRERVEELEAELEDLE--------EEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE- 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1264 nvqlenktsclketqdqllesqkkekqLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAt 1343
Cdd:PRK02224  542 ---------------------------LRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER- 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1344 nkeLQELLVKSQENEGNLQgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvlesqkkshneiqDKLEQ 1423
Cdd:PRK02224  594 ---IRTLLAAIADAEDEIE----RLREKREALAELNDERRERLAEKRERKRELEAEFDE----------------ARIEE 650

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1424 AQQKERTLQEETSKLAEQLSQLKQANEELQKSLqqkqlllekgNEFDTQLAEYQKVIDEMDDAASVKSAL------LEQL 1497
Cdd:PRK02224  651 AREDKERAEEYLEQVEEKLDELREERDDLQAEI----------GAVENELEELEELRERREALENRVEALealydeAEEL 720

                         650
                  ....*....|....*
gi 28574245  1498 QNRVAELETALRQAN 1512
Cdd:PRK02224  721 ESMYGDLRAELRQRN 735
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 237-814 2.93e-11

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 68.56  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  237 MAVGDRVIVSSGFGsrpgILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV--------------- 301
Cdd:COG5244    4 LSVNDRVLLGDKFG----TVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIrpdddsllngnaaye 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  302 --------------PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTA---TSRMRMN------AQRKSSTPVKPI 358
Cdd:COG5244   80 kikgglvceskgmdKDGEIKQENHEDRIHFEESKIRRLEETIEALKSTEKEEiveLRRENEEldkinlSLRERISSEEPE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  359 LATPKSQFSMQDL--LREKQQHVEKLMVERDLDREDAQNQALQLQKNI--NELKARIVE--------LESALDNERKKTE 426
Cdd:COG5244  160 LNKDGSKLSYDELkeFVEESRVQVYDMVELVSDISETLNRNGSIQRSSvrECERSNIHDvlflvngiLDGVIDELNGELE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  427 ELQ---CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQkeV 503
Cdd:COG5244  240 RLRrqlVSLMSSHGIEVEENSRLKATLEKFQSLELKVNTL--QEELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEV--I 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  504 ESRIAEQLEeeqrlrenvkylNEQIATLQSELVSKDEALEKFSLSECgiENLRRELELLKEENEKQAQEAQAEFTRKLAE 583
Cdd:COG5244  316 ESENFGKLE------------NIEIHIILKVLSSISYALHIYTIKNT--PDHLETTLQCFVNIAPISMWLSEFLQRKFSS 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  584 KSVEVLrlsSELQNLKATSDSLE----------------------SERVNKTDECEILQTEVRMRdeQIRELNQQlDEVT 641
Cdd:COG5244  382 KQETAF---SICQFLEDNKDVTLilkilhpilettvpkllaflrtNSNFNDNDTLCLIGSLYEIA--RIDKLIGK-EEIS 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  642 TQLN----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 717
Cdd:COG5244  456 KQDNrlflYPSCDITLSSILTILFSDKLEVFFQGIESLLENITIFPEQPSQQTSDSENIKENSLLSDRLNEENIRLKEVL 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  718 ENAINQIQLEKESieQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE---KL 794
Cdd:COG5244  536 VQKENMLTEETKI--KIIIGRDLERKTLEENIKTLKVELNNKNNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKiylDL 613

                        650       660
                 ....*....|....*....|
gi 28574245  795 QAALEELKKEKETIIKEKEQ 814
Cdd:COG5244  614 VSEIMELRETIRRQIKEQKR 633
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 383-804 1.60e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 66.23  E-value: 1.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    383 MVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITK 462
Cdd:TIGR02168  672 ILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    463 lvsatpslqsilppdlpsddgaLQEEIAKLQEKMTiqqkEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL 542
Cdd:TIGR02168  752 ----------------------LSKELTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    543 EKFS--LSECGIENLRRELELLKEENEKQAQEAQAEFTRK-LAEKSVEVLRLSSELQNLKATSDSLESERvnktdecEIL 619
Cdd:TIGR02168  806 DELRaeLTLLNEEAANLRERLESLERRIAATERRLEDLEEqIEELSEDIESLAAEIEELEELIEELESEL-------EAL 878

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    620 QTEVRMRDEQIRELNQQLDEVTTQLNvqkadsSALDDMLRLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQLekq 699
Cdd:TIGR02168  879 LNERASLEEALALLRSELEELSEELR------ELESKRSELRRE--------LEELREKLAQLELRLEGLEVRIDNL--- 941

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    700 isdLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFqkkqseSEVHL---QEIKAQNTQKDFelvesges 776
Cdd:TIGR02168  942 ---QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL------GPVNLaaiEEYEELKERYDF-------- 1004

                          410       420
                   ....*....|....*....|....*...
gi 28574245    777 lkkLQQQLEQKTLGHEKLQAALEELKKE 804
Cdd:TIGR02168 1005 ---LTAQKEDLTEAKETLEEAIEEIDRE 1029
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 125-185 1.55e-08

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 59.70  E-value: 1.55e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245  125 IGQRVWLGGTRpGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSR 185
Cdd:COG5244    6 VNDRVLLGDKF-GTVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIR 65
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 486-769 3.79e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.13  E-value: 3.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    486 QEEIAKLQEKMTIQQKevesRIAEQLEEEQRLRENVKYLNEQIATLqselVSKDEALEKFSLSECGIENLRRELELLKEE 565
Cdd:pfam17380  332 QAAIYAEQERMAMERE----RELERIRQEERKRELERIRQEEIAME----ISRMRELERLQMERQQKNERVRQELEAARK 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    566 NEKQAQEAQaeftRKLAEKSVEVLRLSSELQNLKATS-DSLESERVNktdECEILQTEVRMRDEQIRELNQQLDEvttql 644
Cdd:pfam17380  404 VKILEEERQ----RKIQQQKVEMEQIRAEQEEARQREvRRLEEERAR---EMERVRLEEQERQQQVERLRQQEEE----- 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    645 nvQKADSSALDDMLRLQKEGTEEKSTLLEKtekELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI 724
Cdd:pfam17380  472 --RKRKKLELEKEKRDRKRAEEQRRKILEK---ELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQ 546

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 28574245    725 QL-EKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFE 769
Cdd:pfam17380  547 EMeERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYE 592
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1667-1683 1.30e-06

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 45.92  E-value: 1.30e-06
                           10
                   ....*....|....*..
gi 28574245   1667 RKYCDSCEVFGHDTSEC 1683
Cdd:pfam16641    1 RPYCEICEVFGHDTEDC 17
PRK11281 PRK11281
mechanosensitive channel MscK;
413-823 2.22e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 52.61  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   413 ELESALD--NERKKTEE----LQCSIDEAQfcgdELNAQSQVYKEKIHDLESKITKlvsATPSLQSIlppdlpsddgalQ 486
Cdd:PRK11281   40 DVQAQLDalNKQKLLEAedklVQQDLEQTL----ALLDKIDRQKEETEQLKQQLAQ---APAKLRQA------------Q 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   487 EEIAKLQEKM---------TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSelvskdealekfslsecgienlrr 557
Cdd:PRK11281  101 AELEALKDDNdeetretlsTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQT------------------------ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   558 elellkeenekQAQEAQAEftrkLAEKSVEVLRLSSELQNLKATSDSLESERVNKtdeceiLQTEVRMRDEQIrELNQQL 637
Cdd:PRK11281  157 -----------QPERAQAA----LYANSQRLQQIRNLLKGGKVGGKALRPSQRVL------LQAEQALLNAQN-DLQRKS 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   638 DEVTTQLNvqkadssaldDMLRLQKEGTEEKSTLLEKT---------EKELVQSKEQAAKTLNDKE------------QL 696
Cdd:PRK11281  215 LEGNTQLQ----------DLLQKQRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEaariqanplvaqEL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   697 E--KQISD--------LKQLAEQEKLVREMTENAINQIQLEKESI--------------EQQLALKQNEL-EDFQKKQSE 751
Cdd:PRK11281  285 EinLQLSQrllkatekLNTLTQQNLRVKNWLDRLTQSERNIKEQIsvlkgslllsrilyQQQQALPSADLiEGLADRIAD 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   752 SEVHLQEIkaqNTQKDfELVESGESLKKLQQQleQKTLGHEKLQAALEELKKEKETIIKEKEQEL--------------Q 817
Cdd:PRK11281  365 LRLEQFEI---NQQRD-ALFQPDAYIDKLEAG--HKSEVTDEVRDALLQLLDERRELLDQLNKQLnnqlnlainlqlnqQ 438


                  ....*.
gi 28574245   818 QLQSKS 823
Cdd:PRK11281  439 QLLSVS 444
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1620-1637 9.53e-05

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 40.91  E-value: 9.53e-05
                           10
                   ....*....|....*...
gi 28574245   1620 RLFCDICDEFDqHDTEDC 1637
Cdd:pfam16641    1 RPYCEICEVFG-HDTEDC 17
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1428-1597 4.22e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1428 ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL---EKGNEFDTQLAEYQkVIDEMDDAASV--KSALLEQLQNRVA 1502
Cdd:COG4913  220 EPDTFEAADALVEHFDDLERAHEALEDAREQIELLEpirELAERYAAARERLA-ELEYLRAALRLwfAQRRLELLEAELE 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1503 ELETALRQANDAQKtayletkELRRQLESLEleksREVLSLKAQMNGASsrsgkGDEVESLDietslAKINFLNSIIADM 1582
Cdd:COG4913  299 ELRAELARLEAELE-------RLEARLDALR----EELDELEAQIRGNG-----GDRLEQLE-----REIERLERELEER 357

                        170
                 ....*....|....*
gi 28574245 1583 QQKNDALKAKVQTLE 1597
Cdd:COG4913  358 ERRRARLEALLAALG 372
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 630-1010 7.86e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 7.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   630 IRELNQQLDEVTTQLNVqkadsSALDDMLRLQKEGTEEKSTLLEKTEKELvqSKEQAAKTLNDKEQLEKQISDL-KQLAE 708
Cdd:NF033838   71 LSEIQKSLDKRKHTQNV-----ALNKKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKDTLEPgKKVAE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   709 QEKLVREMTENAINQIQlEKESIEQQLALKQNELE--DFQKKQSESEVHLQEIKAQNTQKDfelvesgESLKKLQQQLEQ 786
Cdd:NF033838  144 ATKKVEEAEKKAKDQKE-EDRRNYPTNTYKTLELEiaESDVEVKKAELELVKEEAKEPRDE-------EKIKQAKAKVES 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   787 KtlgheklQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLK 866
Cdd:NF033838  216 K-------KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   867 SQAEET--QSELKSTQSNLEAKSKQLEAangslEEEAKksghlleqitKLKSEVGETQAALSSCHTDVESKTKQLEAANA 944
Cdd:NF033838  289 SVGEETlpSPSLKPEKKVAEAEKKVEEA-----KKKAK----------DQKEEDRRNYPTNTYKTLELEIAESDVKVKEA 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   945 ALEKVNKEYAESRAEasdlqDKVKEItdtlhaelQAERSSSSALHTKLSKFSDEIATGHKELTSKA 1010
Cdd:NF033838  354 ELELVKEEAKEPRNE-----EKIKQA--------KAKVESKKAEATRLEKIKTDRKKAEEEAKRKA 406
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
 1196-1344 8.90e-04

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 42.79  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1196 KLKQAQQSEQKLQQESQTSKEKLteiQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLK 1275
Cdd:cd21116   74 YYPDLIELADNLIKGDQGAKQQL---LQGLEALQSQVTKKQTSVTSFINELTTFKNDLDDDSRNLQTDATKAQAQVAVLN 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245 1276 ETQDQLlesqkkeKQLQEEAAKLSGELQQVQEANGDIKDSLvkveelvKVLEEKLQAATSQLDAQQATN 1344
Cdd:cd21116  151 ALKNQL-------NSLAEQIDAAIDALEKLSNDWQTLDSDI-------KELITDLEDAESSIDAAFLQA 205
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1220-1447 1.24e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.08  E-value: 1.24e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    1220 EIQQ-SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQlLESQK-----KEKQLQE 1293
Cdd:smart00787   66 ELYQfSCKELKKYISEGRDLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQFQLVKTFAR-LEAKKmwyewRMKLLEG 144

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    1294 EAAKLSGELQQVQEAngdiKDSLVKVEELVKVLEEKLQaatsqlDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQ 1373
Cdd:smart00787  145 LKEGLDENLEGLKED----YKLLMKELELLNSIKPKLR------DRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLK 214

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574245    1374 QLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTlqeETSKLAEQLSQLKQ 1447
Cdd:smart00787  215 KLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFK---EIEKLKEQLKLLQS 285
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-118 1.47e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245     2 SDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPqpskmkAPSSFGSTGSVSKIGRPCCNHTTP 81
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST------SSSSESSRGAAVSPGPSPSRSPSP 353

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 28574245    82 KSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTA 118
Cdd:PHA03307  354 SRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRA 390
 
Name Accession Description Interval E-value
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 239-306 9.93e-34

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 124.44  E-value: 9.93e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245    239 VGDRVIVSsgfGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 306
Cdd:pfam01302    1 VGDRVEVP---GGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 125-189 6.43e-30

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 113.27  E-value: 6.43e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245    125 IGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRL 189
Cdd:pfam01302    1 VGDRVEVPGGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 637-1490 1.66e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 128.64  E-value: 1.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    637 LDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEklvrem 716
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------ 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    717 tenaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 796
Cdd:TIGR02168  269 ----LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    797 ALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQ 873
Cdd:TIGR02168  345 KLEELKEELESLeaeLEELEAELEELESRLEELEEQL------------------ETLRSKVAQLELQIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    874 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 953
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELLKKLEEAELKE--LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    954 AESRA----------EASDLQDKVKE----------ITDTLHAELQAERSSSSALHTKLSKFSDEIATghkelTSKADAW 1013
Cdd:TIGR02168  485 AQLQArldslerlqeNLEGFSEGVKAllknqsglsgILGVLSELISVDEGYEAAIEAALGGRLQAVVV-----ENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1014 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEVTKAKTeNLELSTGTQTTIKDLQERLEIT 1091
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKniEGFLGVAKDLVKFDPKLRK-ALSYLLGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1092 NaELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELstvlevlqaeksetnhifelfemeadmnsERLIEKVTG 1171
Cdd:TIGR02168  639 K-KLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREI-----------------------------EELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1172 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSS 1251
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1252 IIEAQNTKLNESNVQLENKTSCLKETQDQ-------LLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1324
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEElkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1325 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:TIGR02168  849 ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1405 TVLESQKKSHNEIQDKL--------EQAQQKERTLQEETSKLAEQLSQLKQ-----------ANEELQKSLQQKQLLLEK 1465
Cdd:TIGR02168  929 LRLEGLEVRIDNLQERLseeysltlEEAEALENKIEDDEEEARRRLKRLENkikelgpvnlaAIEEYEELKERYDFLTAQ 1008

                          890       900
                   ....*....|....*....|....*
gi 28574245   1466 GNEFDTQLAEYQKVIDEMDDAASVK 1490
Cdd:TIGR02168 1009 KEDLTEAKETLEEAIEEIDREARER 1033
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 239-307 2.68e-29

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 111.91  E-value: 2.68e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245     239 VGDRVIVSSGfgSRPGILRYLGETQFAPGNWCGVELDEP-SGKNDGTVDDIRYFECKPKYGVFVPIAKVS 307
Cdd:smart01052    1 VGDRVEVGGG--GRRGTVRYVGPTPFAPGVWVGVELDEPlRGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 628-1429 4.29e-26

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 117.48  E-value: 4.29e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    628 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKE----QLEKQISDL 703
Cdd:TIGR02169  184 ENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEeeleKLTEEISEL 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    704 KQ--------LAEQEKLVREMTENAINQIQ-------LEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQntqkdf 768
Cdd:TIGR02169  264 EKrleeieqlLEELNKKIKDLGEEEQLRVKekigeleAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAE------ 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    769 elvesgesLKKLQQQLEQKTLGHEKLQAALEELKKEKETIikekEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASG 848
Cdd:TIGR02169  338 --------IEELEREIEEERKRRDKLTEEYAELKEELEDL----RAELEEVDKEFAETRDELKDYREKLEKLKREINELK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    849 EEGSK---TVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAAL 925
Cdd:TIGR02169  406 RELDRlqeELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKEL 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    926 SSchtdvesKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALhtklskfsdEIATGH-- 1003
Cdd:TIGR02169  486 SK-------LQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAI---------EVAAGNrl 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1004 KELTSKADAWSQEMLQKEKELQELRQ------QLQDSQDSQTKLKAEG------------ERKEKSFE---------ESI 1056
Cdd:TIGR02169  550 NNVVVEDDAVAKEAIELLKRRKAGRAtflplnKMRDERRDLSILSEDGvigfavdlvefdPKYEPAFKyvfgdtlvvEDI 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1057 KNLQEEVTKAKTENLE---------------LSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQV 1121
Cdd:TIGR02169  630 EAARRLMGKYRMVTLEgelfeksgamtggsrAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQ 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1122 ANANISATNAELSTVLEVLQAEKSETNHIFElfEMEADMNSerLIEKVTGIKEELKETHLQLDERQKKFEELEEKL---- 1197
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLE--ELEEDLSS--LEQEIENVKSELKELEARIEELEEDLHKLEEALndle 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1198 --------KQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLEN 1269
Cdd:TIGR02169  786 arlshsriPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE 865

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1270 KTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQE 1349
Cdd:TIGR02169  866 LEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEE 945

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1350 lLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDesntVLESQKKshnEIQDKLEQAQQKER 1429
Cdd:TIGR02169  946 -IPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRA----KLEEERK---AILERIEEYEKKKR 1017
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 747-1541 2.11e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 111.69  E-value: 2.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    747 KKQSESEVHLQEIKAQNTQKDFELveSGESLKKLQQQLEQKtlghEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES 826
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELAL--LVLRLEELREELEEL----QEELKEAEEELEELTAELQELEEKLEELRLEVSEL 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    827 ESALKVVQVQLEQLqqqaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGH 906
Cdd:TIGR02168  280 EEEIEELQKELYAL-----------ANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    907 LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLhAELQAERSS-- 984
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRR-ERLQQEIEEll 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    985 SSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEE 1062
Cdd:TIGR02168  428 KKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEG 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1063 VTKAKTENLELSTGTQTtikdLQERLEITNAELQHKEKMASEDAQKIadlktLVEAIQVANANISA---TNAELSTVLE- 1138
Cdd:TIGR02168  508 VKALLKNQSGLSGILGV----LSELISVDEGYEAAIEAALGGRLQAV-----VVENLNAAKKAIAFlkqNELGRVTFLPl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1139 -VLQAEKSETNHIFELFEMEADMNSERLIEK------------------VTGIKEEL----------------------- 1176
Cdd:TIGR02168  579 dSIKGTEIQGNDREILKNIEGFLGVAKDLVKfdpklrkalsyllggvlvVDDLDNALelakklrpgyrivtldgdlvrpg 658

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1177 -------KETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRES 1249
Cdd:TIGR02168  659 gvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARL 738

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1250 SSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEK 1329
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1330 LQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEAlcqkengLKELQGKLDESNTVLES 1409
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE-------LEALLNERASLEEALAL 891

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1410 QKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQkqlLLEKGNEfdtqlaEYQKVIDEMDDAASV 1489
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN---LQERLSE------EYSLTLEEAEALENK 962

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245   1490 KSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE-----LEKSREVL 1541
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYDFLTaqkedLTEAKETL 1019
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 499-1458 3.19e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 111.30  E-value: 3.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    499 QQKEVESRIAEQLEEEQRLRENVKYLNEQIATL--QSELVSK----DEALEKFSLSECGIE-NLRRELELLKEENEKQAQ 571
Cdd:TIGR02168  173 RRKETERKLERTRENLDRLEDILNELERQLKSLerQAEKAERykelKAELRELELALLVLRlEELREELEELQEELKEAE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    572 EAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLnvQKADS 651
Cdd:TIGR02168  253 EELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL--EELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    652 SALDDMLRLQKEGTEekstlLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKlvremteNAINQIQLEKESI 731
Cdd:TIGR02168  331 KLDELAEELAELEEK-----LEELKEELESLEAELEELEAELEELESRLEELEEQLETLR-------SKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    732 eqqlalkQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESgeSLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKE 811
Cdd:TIGR02168  399 -------NNEIERLEARLERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREE 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    812 KEQELQQLQsksaesesalkvvqvqleqlqqqaaasgeegsktvaklhdeisQLKSQAEETQSELKSTQSNLEAKSKQLE 891
Cdd:TIGR02168  470 LEEAEQALD-------------------------------------------AAERELAQLQARLDSLERLQENLEGFSE 506

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    892 AANGSLEEEAKKSGHLLEQITKLKSEVGETQA---ALSSCHTDVESKTkqLEAANAALekvnkeyaESRAEASDLQDKVK 968
Cdd:TIGR02168  507 GVKALLKNQSGLSGILGVLSELISVDEGYEAAieaALGGRLQAVVVEN--LNAAKKAI--------AFLKQNELGRVTFL 576

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    969 EITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEkELQElrqqlqdsqdsqtklkAEGERK 1048
Cdd:TIGR02168  577 PLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVD-DLDN----------------ALELAK 639

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1049 EKSFEESIKNLQEE-------VTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQV 1121
Cdd:TIGR02168  640 KLRPGYRIVTLDGDlvrpggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK 719

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1122 ANANISATNAELSTVLEVLQAEksetnhifelfemeadmnSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQ 1201
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAE------------------VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1202 QSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQL 1281
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI 861

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1282 LESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNL 1361
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL 941

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1362 QG---ESLAVTEKLQQLEQANGELKEALCQKEngLKELQGKLDESNTV-------LESQKKSHNEIQDKLEQAQQKERTL 1431
Cdd:TIGR02168  942 QErlsEEYSLTLEEAEALENKIEDDEEEARRR--LKRLENKIKELGPVnlaaieeYEELKERYDFLTAQKEDLTEAKETL 1019

                          970       980
                   ....*....|....*....|....*...
gi 28574245   1432 QEETSKL-AEQLSQLKQANEELQKSLQQ 1458
Cdd:TIGR02168 1020 EEAIEEIdREARERFKDTFDQVNENFQR 1047
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 694-1541 1.11e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 109.39  E-value: 1.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    694 EQLEKQISDLKQLAEQEKLVREMTENAINQiqLEKESIEQQLALKQNELEDfQKKQSESEVHLQEIKAQNTQK---DFEL 770
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQ--LERLRREREKAERYQALLK-EKREYEGYELLKEKEALERQKeaiERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    771 VESGESLKKLQQQLEQKTLGHEKLQAALEELKKEketIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEE 850
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKK---IKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    851 GSKTVAKLHD---EISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLL-------EQITKLKSEVGE 920
Cdd:TIGR02169  324 LAKLEAEIDKllaEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRdelkdyrEKLEKLKREINE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    921 TQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEIT---DTLHAELQAERSSSSALHTKLSKFSD 997
Cdd:TIGR02169  404 LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEwklEQLAADLSKYEQELYDLKEEYDRVEK 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    998 EIATGHKELTSK---ADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKN-LQ------EEVTKAK 1067
Cdd:TIGR02169  484 ELSKLQRELAEAeaqARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNrLNnvvvedDAVAKEA 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1068 TENLELSTGTQTTIkdlqerLEITNAELQHKEKMASEDAQKIADLKTLVE-AIQVANANISATNAELstVLEVLQAEKsE 1146
Cdd:TIGR02169  564 IELLKRRKAGRATF------LPLNKMRDERRDLSILSEDGVIGFAVDLVEfDPKYEPAFKYVFGDTL--VVEDIEAAR-R 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1147 TNHIFELFEMEADmnserLIEK---VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQ 1223
Cdd:TIGR02169  635 LMGKYRMVTLEGE-----LFEKsgaMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQ 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1224 SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGEL- 1302
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLs 789

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1303 -QQVQEangdIKDSLVKVEELVKVLEEKLQaatsqlDAQQATNKELQELLVKSQENEgNLQGESLAVTEKLQQLEQANGE 1381
Cdd:TIGR02169  790 hSRIPE----IQAELSKLEEEVSRIEARLR------EIEQKLNRLTLEKEYLEKEIQ-ELQEQRIDLKEQIKSIEKEIEN 858

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1382 LKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKslqqkql 1461
Cdd:TIGR02169  859 LNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE------- 931

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1462 llekgnefdtQLAEYQKVIDEMDDaASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLesLELEKSREVL 1541
Cdd:TIGR02169  932 ----------ELSEIEDPKGEDEE-IPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRL--DELKEKRAKL 998
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1167-1518 3.30e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.72  E-value: 3.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1167 EKVTGIKEELKETHLQL-----DERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQN 1241
Cdd:COG1196  213 ERYRELKEELKELEAELlllklRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1242 LEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1321
Cdd:COG1196  293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1322 LVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLD 1401
Cdd:COG1196  373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1402 ESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVID 1481
Cdd:COG1196  453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 28574245 1482 EMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1518
Cdd:COG1196  533 EAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAA 569
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 125-190 3.47e-23

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 94.19  E-value: 3.47e-23
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245     125 IGQRVWLGGT-RPGQIAFIGDTHFAAGEWAGVVLDEPN-GKNDGCVSGKRYFQCEPKRGIFSRLTRLT 190
Cdd:smart01052    1 VGDRVEVGGGgRRGTVRYVGPTPFAPGVWVGVELDEPLrGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 372-1089 2.88e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 104.75  E-value: 2.88e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    372 LREKQQHVEKL-MVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQfcgDELNAQSQvyk 450
Cdd:TIGR02168  222 LRELELALLVLrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ---KELYALAN--- 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    451 eKIHDLESKITKLVSATPSLQsilppdlpSDDGALQEEIAKLQEKMTIQQKE---VESRIAEQLEEEQRLRENVKYLNEQ 527
Cdd:TIGR02168  296 -EISRLEQQKQILRERLANLE--------RQLEELEAQLEELESKLDELAEElaeLEEKLEELKEELESLEAELEELEAE 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    528 IATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSS-ELQNLKATSDSLE 606
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaELKELQAELEELE 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    607 SERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEK--------- 677
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilgvls 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    678 ELVQSKEQAAKTL-------------NDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELED 744
Cdd:TIGR02168  527 ELISVDEGYEAAIeaalggrlqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKD 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    745 FQKKQSESEVHLQEI-----------KAQNTQK-----------DFELVESG------------------ESLKKLQQQL 784
Cdd:TIGR02168  607 LVKFDPKLRKALSYLlggvlvvddldNALELAKklrpgyrivtlDGDLVRPGgvitggsaktnssilerrREIEELEEKI 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    785 EQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESeSALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQ 864
Cdd:TIGR02168  687 EELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQI-SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    865 LKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANA 944
Cdd:TIGR02168  766 LEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    945 ALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSdeiatghkELTSKADAWSQEMLQKEKEL 1024
Cdd:TIGR02168  846 QIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE--------ELSEELRELESKRSELRREL 917

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245   1025 QELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLE 1089
Cdd:TIGR02168  918 EELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 862-1505 1.54e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 102.32  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  862 ISQLKSQAEETQSELKSTQSNLE-------AKSKQLEaangSLEEEAKKsghlLEQITKLKSEVGETQAALS-----SCH 929
Cdd:COG1196  167 ISKYKERKEEAERKLEATEENLErledilgELERQLE----PLERQAEK----AERYRELKEELKELEAELLllklrELE 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  930 TDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALhtklskfsDEIATGHKELTSK 1009
Cdd:COG1196  239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAEL--------ARLEQDIARLEER 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1010 ADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLE 1089
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1090 ITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSEtnhifELFEMEADMNSERLIEKV 1169
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA-----AEEEAELEEEEEALLELL 465

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1170 TGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVkqkEELVQNLEEKVRES 1249
Cdd:COG1196  466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV---LIGVEAAYEAALEA 542

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1250 SSIIEAQNtKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEK 1329
Cdd:COG1196  543 ALAAALQN-IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDT 621

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1330 LQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvles 1409
Cdd:COG1196  622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE------- 694

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1410 qkkshnEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEkgnEFDTQLAEYQKVIDEMDDAASV 1489
Cdd:COG1196  695 ------LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLE---EEELLEEEALEELPEPPDLEEL 765

                        650
                 ....*....|....*.
gi 28574245 1490 KSAlLEQLQNRVAELE 1505
Cdd:COG1196  766 ERE-LERLEREIEALG 780
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 390-1228 1.82e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 102.06  E-value: 1.82e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    390 REDAQNQALQLQKNINELKARIVELESALDN---------------ERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIH 454
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDILNELERQLKSlerqaekaerykelkAELRELELALLVLRLEELREELEELQEELKEAEE 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    455 DLESKITKLVSATPSLQsilppDLPSDDGALQEEIAKLQEKM---TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATL 531
Cdd:TIGR02168  254 ELEELTAELQELEEKLE-----ELRLEVSELEEEIEELQKELyalANEISRLEQQKQILRERLANLERQLEELEAQLEEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    532 QSelvSKDEALEKFSLSECGIEnLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVN 611
Cdd:TIGR02168  329 ES---KLDELAEELAELEEKLE-ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIER 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    612 KTDECEILQTEVRMRDEQIRELNQQLDEvtTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLN 691
Cdd:TIGR02168  405 LEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAER 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    692 DKEQLEKQISDLKQLAEQEklvrEMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQE------------- 758
Cdd:TIGR02168  483 ELAQLQARLDSLERLQENL----EGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGrlqavvvenlnaa 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    759 IKAQNTQKDFE------LVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKE------------TIIKEKEQELQQLQ 820
Cdd:TIGR02168  559 KKAIAFLKQNElgrvtfLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPklrkalsyllggVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    821 SKSAESESALKVVQVQLEQLQQQAAASGEEGSKTV------AKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAAN 894
Cdd:TIGR02168  639 KKLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILerrreiEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLR 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    895 GSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDtl 974
Cdd:TIGR02168  719 KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE-- 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    975 haELQAERSSSSALHTKLSKFSDEIAtghkELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEE 1054
Cdd:TIGR02168  797 --ELKALREALDELRAELTLLNEEAA----NLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1055 SIKNLqEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISAT-NAEL 1133
Cdd:TIGR02168  871 LESEL-EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlSEEY 949

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1134 STVLEVLQAEKSETnhifELFEMEADMNSERLIEKVTGIK-------EELKETHLQLDERQKKFEELEEKLKQAQQSEQK 1206
Cdd:TIGR02168  950 SLTLEEAEALENKI----EDDEEEARRRLKRLENKIKELGpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEE 1025

                          890       900
                   ....*....|....*....|...
gi 28574245   1207 LQQE-SQTSKEKLTEIQQSLQEL 1228
Cdd:TIGR02168 1026 IDREaRERFKDTFDQVNENFQRV 1048
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 629-1209 7.50e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 100.01  E-value: 7.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  629 QIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAE 708
Cdd:COG1196  233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  709 QEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKT 788
Cdd:COG1196  313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  789 LGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQ 868
Cdd:COG1196  393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  869 AEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVEskTKQLEAANAALEK 948
Cdd:COG1196  473 ALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE--AALEAALAAALQN 550

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  949 VNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQkekELQELR 1028
Cdd:COG1196  551 IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDT---LLGRTL 627

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1029 QQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVT-KAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQ 1107
Cdd:COG1196  628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTgGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEER 707

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1108 KIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKEthL------ 1181
Cdd:COG1196  708 ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA--Lgpvnll 785

                        570       580       590
                 ....*....|....*....|....*....|.
gi 28574245 1182 ---QLDERQKKFEELEEKLKQAQQSEQKLQQ 1209
Cdd:COG1196  786 aieEYEELEERYDFLSEQREDLEEARETLEE 816
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1191-1515 1.38e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.77  E-value: 1.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1191 EELEEKLKQ-AQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssiIEAQNTKLNESNVQLEN 1269
Cdd:COG1196  196 GELERQLEPlERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAE----LEELEAELAELEAELEE 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1270 KTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQE 1349
Cdd:COG1196  272 LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1350 LLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKER 1429
Cdd:COG1196  352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALA 431

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1430 TLQEETSKLAEQLSQLKQANEELQ-KSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETAL 1508
Cdd:COG1196  432 ELEEEEEEEEEALEEAAEEEAELEeEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511


                 ....*..
gi 28574245 1509 RQANDAQ 1515
Cdd:COG1196  512 AALLLAG 518
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 666-1539 4.10e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 94.65  E-value: 4.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    666 EEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLA--EQEKLVREMTENAINQIQLEKESIEQQLALKQNELE 743
Cdd:pfam02463  186 AELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLylDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    744 DFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKeketiikeKEQELQQLQSKS 823
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK--------AEKELKKEKEEI 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    824 AESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 903
Cdd:pfam02463  338 EELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    904 SGHLLEQITKLKSEVGETQaalsschTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERS 983
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEE-------ESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    984 SSSALHTKLSKFSDEIATGHKELTSKADawsqemlqkekelqelrqqlqdsqDSQTKLKAEGERKEKSFEESIKNLQEEV 1063
Cdd:pfam02463  491 SRQKLEERSQKESKARSGLKVLLALIKD------------------------GVGGRIISAHGRLGDLGVAVENYKVAIS 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1064 TKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAE 1143
Cdd:pfam02463  547 TAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVE 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1144 KSETNHIFELFEMEADMNSERLIEKVTGIKEElkethLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQ 1223
Cdd:pfam02463  627 GILKDTELTKLKESAKAKESGLRKGVSLEEGL-----AEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1224 SLQELqdsvKQKEELVQNLEEKVResssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQ 1303
Cdd:pfam02463  702 KKKEQ----REKEELKKLKLEAEE-----LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1304 QVQEANGDIKDSLVKVEELvkvLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELK 1383
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEE---KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1384 EALCQKENGLKELQGKLDESNtvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL 1463
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQ--ELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA 927

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   1464 EKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSRE 1539
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE 1003
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 369-1028 7.64e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 93.58  E-value: 7.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    369 QDLLREKQQHVEKLmverdldrEDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQV 448
Cdd:TIGR02168  298 SRLEQQKQILRERL--------ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEE 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    449 YKEKIHDLESKITKLVSATPSLQSILppdlpsddGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENvkylneQI 528
Cdd:TIGR02168  370 LESRLEELEEQLETLRSKVAQLELQI--------ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA------EL 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    529 ATLQSELVSKDEALEKfslsecgienlrrelellKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESE 608
Cdd:TIGR02168  436 KELQAELEELEEELEE------------------LQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    609 RVNKtdecEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDML--RLQK------------------------ 662
Cdd:TIGR02168  498 QENL----EGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALggRLQAvvvenlnaakkaiaflkqnelgrv 573

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    663 ---EGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEK----------- 728
Cdd:TIGR02168  574 tflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRpgyrivtldgd 653

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    729 ------------ESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 796
Cdd:TIGR02168  654 lvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    797 ALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEgSKTVAKLHDEISQLKSQAEETQSEL 876
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL-EAQIEQLKEELKALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    877 KST-------QSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKV 949
Cdd:TIGR02168  813 TLLneeaanlRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALL 892

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    950 NKEYAESRAEASDLQDKVKEitdtLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSK----ADAWSQEMLQKEKELQ 1025
Cdd:TIGR02168  893 RSELEELSEELRELESKRSE----LRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEysltLEEAEALENKIEDDEE 968


                   ...
gi 28574245   1026 ELR 1028
Cdd:TIGR02168  969 EAR 971
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
890-1512 1.60e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 92.41  E-value: 1.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   890 LEAANGSLEE-----EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEkvnkEYAESRAEASDLQ 964
Cdd:PRK02224  182 LSDQRGSLDQlkaqiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLE----EHEERREELETLE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   965 DKVKEITDTLhAELQAERSS-SSALHTK---LSKFSDEIA-----TGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ 1035
Cdd:PRK02224  258 AEIEDLRETI-AETEREREElAEEVRDLrerLEELEEERDdllaeAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1036 DSQTKLKAEGERkeksfeESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEitnaelqhkekmasedaqKIADLKTL 1115
Cdd:PRK02224  337 AQAHNEEAESLR------EDADDLEERAEELREEAAELESELEEAREAVEDRRE------------------EIEELEEE 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1116 VEAIQVANANISATNAELSTVLEVLQAEKSETNHifELFEMEADMNSER-LIEKVTGIKEELK----------ETHLQ-L 1183
Cdd:PRK02224  393 IEELRERFGDAPVDLGNAEDFLEELREERDELRE--REAELEATLRTAReRVEEAEALLEAGKcpecgqpvegSPHVEtI 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1184 DERQKKFEELEEKLKQAQqseqklqqESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNEs 1263
Cdd:PRK02224  471 EEDRERVEELEAELEDLE--------EEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE- 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1264 nvqlenktsclketqdqllesqkkekqLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAt 1343
Cdd:PRK02224  542 ---------------------------LRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER- 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1344 nkeLQELLVKSQENEGNLQgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvlesqkkshneiqDKLEQ 1423
Cdd:PRK02224  594 ---IRTLLAAIADAEDEIE----RLREKREALAELNDERRERLAEKRERKRELEAEFDE----------------ARIEE 650

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1424 AQQKERTLQEETSKLAEQLSQLKQANEELQKSLqqkqlllekgNEFDTQLAEYQKVIDEMDDAASVKSAL------LEQL 1497
Cdd:PRK02224  651 AREDKERAEEYLEQVEEKLDELREERDDLQAEI----------GAVENELEELEELRERREALENRVEALealydeAEEL 720

                         650
                  ....*....|....*
gi 28574245  1498 QNRVAELETALRQAN 1512
Cdd:PRK02224  721 ESMYGDLRAELRQRN 735
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 591-1327 5.32e-18

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 90.46  E-value: 5.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    591 LSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKST 670
Cdd:TIGR04523   45 IKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEV 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    671 LLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQS 750
Cdd:TIGR04523  125 ELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLS 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    751 ESEVHLQEIKAQNTQkdfeLVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAL 830
Cdd:TIGR04523  205 NLKKKIQKNKSLESQ----ISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNN 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    831 KVVqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEetQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQ 910
Cdd:TIGR04523  281 KKI---------------KELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQ 343

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    911 ITKLKSEVGETQaalsschTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQdkvkeitdtlhaelqaerSSSSALHT 990
Cdd:TIGR04523  344 ISQLKKELTNSE-------SENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLE------------------SQINDLES 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    991 KLSKFSDEiatgHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEN 1070
Cdd:TIGR04523  399 KIQNQEKL----NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLS 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1071 LElstgtqttIKDLQERLEITNAELQHKEKMASEDAQKIADLKtlvEAIQVANANISatnaELSTVLEVLQAEKSETNHI 1150
Cdd:TIGR04523  475 RS--------INKIKQNLEQKQKELKSKEKELKKLNEEKKELE---EKVKDLTKKIS----SLKEKIEKLESEKKEKESK 539

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1151 F-----ELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSL 1225
Cdd:TIGR04523  540 IsdledELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKEL 619

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1226 QELQDSVKQKEELVQNLE---EKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQD---QLLESQKKEKQLQEEAAKLS 1299
Cdd:TIGR04523  620 EKAKKENEKLSSIIKNIKskkNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDdiiELMKDWLKELSLHYKKYITR 699

                          730       740       750
                   ....*....|....*....|....*....|..
gi 28574245   1300 ----GELQQVQEANGDIKDSLVKVEELVKVLE 1327
Cdd:TIGR04523  700 miriKDLPKLEEKYKEIEKELKKLDEFSKELE 731
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 502-1442 6.07e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 90.62  E-value: 6.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    502 EVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEftRKL 581
Cdd:pfam01576   79 ELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKE--RKL 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    582 AEKSVEvlRLSSELQNLKATSDSLEseRVNKTDECEILQTEVRMRDEQ-----IRELNQQLDEVTTQLNVQKADSSALDD 656
Cdd:pfam01576  157 LEERIS--EFTSNLAEEEEKAKSLS--KLKNKHEAMISDLEERLKKEEkgrqeLEKAKRKLEGESTDLQEQIAELQAQIA 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    657 MLRLQKEGTEEK-STLLEKTEKELVQsKEQAAKTLndkEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQL 735
Cdd:pfam01576  233 ELRAQLAKKEEElQAALARLEEETAQ-KNNALKKI---RELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTEL 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    736 --------------ALKQNELEDFQKKQSES----EVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEK---- 793
Cdd:pfam01576  309 edtldttaaqqelrSKREQEVTELKKALEEEtrshEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESenae 388

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    794 LQAALEEL---KKEKETIIKEKEQELQQLQSKSAESESA---LKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKS 867
Cdd:pfam01576  389 LQAELRTLqqaKQDSEHKRKKLEGQLQELQARLSESERQraeLAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLES 468

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    868 QAEETQSELKS---TQSNLEAKSKQLEAANGSL----EEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLE 940
Cdd:pfam01576  469 QLQDTQELLQEetrQKLNLSTRLRQLEDERNSLqeqlEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK 548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    941 AANAALEKVNKEYAESRAEASDLQ---DKVKEITDTLHAELQAERSSSSALHTKLSKFSD------EIATGHKELTSKAD 1011
Cdd:pfam01576  549 RLQRELEALTQQLEEKAAAYDKLEktkNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQmlaeekAISARYAEERDRAE 628

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1012 AWSQE----MLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKS----------FEESIKNLQEEVTKAKTENLELSTGT 1077
Cdd:pfam01576  629 AEAREketrALSLARALEEALEAKEELERTNKQLRAEMEDLVSSkddvgknvheLERSKRALEQQVEEMKTQLEELEDEL 708

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1078 QTTiKDLQERLEIT--------NAELQHKEKMASED----AQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKS 1145
Cdd:pfam01576  709 QAT-EDAKLRLEVNmqalkaqfERDLQARDEQGEEKrrqlVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQID 787

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1146 ETNHIFElfemEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSL 1225
Cdd:pfam01576  788 AANKGRE----EAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQER 863

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1226 QELQDSV--------------KQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQL 1291
Cdd:pfam01576  864 DELADEIasgasgksalqdekRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQL 943

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1292 QEEAAKLSGELqqvQEANGDIKDslvKVEELVKVLEEKLQAATSQLDaQQATNKELQELLVKSQENEgnLQGESLAVTEK 1371
Cdd:pfam01576  944 ERQNKELKAKL---QEMEGTVKS---KFKSSIAALEAKIAQLEEQLE-QESRERQAANKLVRRTEKK--LKEVLLQVEDE 1014

                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245   1372 LQQLEQangeLKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1442
Cdd:pfam01576 1015 RRHADQ----YKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 862-1597 1.57e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 89.35  E-value: 1.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    862 ISQLKSQAEETQSELKSTQSNL---EAKSKQLEAANGSLEEEAKKSghllEQITKLKSEVGETQAALSschtdveskTKQ 938
Cdd:TIGR02168  167 ISKYKERRKETERKLERTRENLdrlEDILNELERQLKSLERQAEKA----ERYKELKAELRELELALL---------VLR 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    939 LEAANAALEKVNKEYAESRAEASDLQDKVKEiTDTLHAELQAErssssalHTKLSKFSDEIATGHKELTSKAdawsQEML 1018
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQE-LEEKLEELRLE-------VSELEEEIEELQKELYALANEI----SRLE 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1019 QKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEnlelstgtqttIKDLQERLEITNAELQHK 1098
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEE-----------LESLEAELEELEAELEEL 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1099 EKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNS-ERLIEKVTGIKEELK 1177
Cdd:TIGR02168  371 ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELE 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1178 ETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIE--- 1254
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSElis 530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1255 -------AQNTKLNES--NVQLENktsclKETQDQLLESQKKEKQ---------LQEEAAKLSGELQQVQEANG--DIKD 1314
Cdd:TIGR02168  531 vdegyeaAIEAALGGRlqAVVVEN-----LNAAKKAIAFLKQNELgrvtflpldSIKGTEIQGNDREILKNIEGflGVAK 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1315 SLVKV-EELVKVLE---------EKLQAATSQ------------LDAQQAT---------NKELQELLVKSQENEgNLQG 1363
Cdd:TIGR02168  606 DLVKFdPKLRKALSyllggvlvvDDLDNALELakklrpgyrivtLDGDLVRpggvitggsAKTNSSILERRREIE-ELEE 684

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1364 ESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS----HNEIQDKLEQAQQKERTLQEETSKLA 1439
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDlarlEAEVEQLEERIAQLSKELTELEAEIE 764

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1440 EQLSQLKQANEELQKSLQQKQLLLEKGNEF-------DTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQAN 1512
Cdd:TIGR02168  765 ELEERLEEAEEELAEAEAEIEELEAQIEQLkeelkalREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLE 844

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1513 DAQKTAYLETKELRRQLESL-----ELEKSREVLS-LKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKN 1586
Cdd:TIGR02168  845 EQIEELSEDIESLAAEIEELeelieELESELEALLnERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL 924

                          810
                   ....*....|.
gi 28574245   1587 DALKAKVQTLE 1597
Cdd:TIGR02168  925 AQLELRLEGLE 935
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1163-1543 4.14e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.60  E-value: 4.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1163 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNL 1242
Cdd:COG1196  249 EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1243 EEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1322
Cdd:COG1196  329 EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA 408

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1323 VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE 1402
Cdd:COG1196  409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1403 SNTVLESQkkshneiqdkleQAQQKERTLQEETSKLAEQLSQLKQANEELqkslqqkQLLLEKGNEFDTQLAEY------ 1476
Cdd:COG1196  489 AAARLLLL------------LEAEADYEGFLEGVKAALLLAGLRGLAGAV-------AVLIGVEAAYEAALEAAlaaalq 549

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245 1477 QKVIDEMDDAASVKSALLEQLQNRVAELE-TALRQANDAQKTAYLETKELRRQLESLELEKSREVLSL 1543
Cdd:COG1196  550 NIVVEDDEVAAAAIEYLKAAKAGRATFLPlDKIRARAALAAALARGAIGAAVDLVASDLREADARYYV 617
PTZ00121 PTZ00121
MAEBL; Provisional
 662-1438 8.38e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 84.04  E-value: 8.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   662 KEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKE-QLEKQISDLKQLAEQEKlvremTENAiNQIQLEKESIEQQLALKQN 740
Cdd:PTZ00121 1121 KKKAEDARKAEEARKAEDARKAEEARKAEDAKRvEIARKAEDARKAEEARK-----AEDA-KKAEAARKAEEVRKAEELR 1194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   741 ELEDFQK----KQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQL-----EQKTLGHEKLQAALEELKKEKETIIKE 811
Cdd:PTZ00121 1195 KAEDARKaeaaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAkkaeeERNNEEIRKFEEARMAHFARRQAAIKA 1274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   812 KE----QELQQLQS--KSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEA 885
Cdd:PTZ00121 1275 EEarkaDELKKAEEkkKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   886 KSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAE----AS 961
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEekkkAD 1434

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   962 DLQDKVKEITDTLHAELQAE--RSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQT 1039
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKKKAEeaKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE 1514

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1040 KLKAEGERKE---KSFEESIKNLQ----EEVTKA----KTENLELSTGTQTTIKDLQERlEITNAELQHKEKMASEDAQK 1108
Cdd:PTZ00121 1515 AKKAEEAKKAdeaKKAEEAKKADEakkaEEKKKAdelkKAEELKKAEEKKKAEEAKKAE-EDKNMALRKAEEAKKAEEAR 1593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1109 IADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADmnSERLIEKVTGIKEELKETHLQLDERQK 1188
Cdd:PTZ00121 1594 IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE--EKKKAEELKKAEEENKIKAAEEAKKAE 1671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1189 KFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEE---KVRESSSIIEAQNTKLNESNV 1265
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEnkiKAEEAKKEAEEDKKKAEEAKK 1751

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1266 QLE--NKTSCLKETQDQLLESQKKEKQL---QEEAAKLSGELQQVQEANGDIKDSLVKVEE-------LVKVLEEKLQAA 1333
Cdd:PTZ00121 1752 DEEekKKIAHLKKEEEKKAEEIRKEKEAvieEELDEEDEKRRMEVDKKIKDIFDNFANIIEggkegnlVINDSKEMEDSA 1831

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1334 TSQLDAQQATNKELQELLVKSQENEGNLQGESlAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1413
Cdd:PTZ00121 1832 IKEVADSKNMQLEEADAFEKHKFNKNNENGED-GNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAGK 1910

                         810       820
                  ....*....|....*....|....*.
gi 28574245  1414 HNE-IQDKLEQAQQKERTLQEETSKL 1438
Cdd:PTZ00121 1911 NNDiIDDKLDKDEYIKRDAEETREEI 1936
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1081-1589 1.86e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 82.29  E-value: 1.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1081 IKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADM 1160
Cdd:COG1196  234 LRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1161 NSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQ 1240
Cdd:COG1196  314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1241 NLEEKVRESSSIIEAQNTKLNESNVQLENKTSC---LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLV 1317
Cdd:COG1196  394 AAAELAAQLEELEEAEEALLERLERLEEELEELeeaLAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1318 KVEELVKVLEEKLQAATSQLDAQQATNKELQELL--VKSQENEGNLQGESLA--------------------------VT 1369
Cdd:COG1196  474 LLEAALAELLEELAEAAARLLLLLEAEADYEGFLegVKAALLLAGLRGLAGAvavligveaayeaaleaalaaalqniVV 553

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1370 EKLQQLEQANGELKEALCQKENGL---KELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQE---ETSKLAEQLS 1443
Cdd:COG1196  554 EDDEVAAAAIEYLKAAKAGRATFLpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDtllGRTLVAARLE 633

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1444 QLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETK 1523
Cdd:COG1196  634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245 1524 ELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDAL 1589
Cdd:COG1196  714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1005-1533 2.37e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.91  E-value: 2.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1005 ELTSKADAWSQEMLQKEK----ELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTG---T 1077
Cdd:COG1196  228 ELLLLKLRELEAELEELEaeleELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDiarL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1078 QTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEME 1157
Cdd:COG1196  308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1158 ADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEE 1237
Cdd:COG1196  388 LLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1238 LVQNLEEKVRESSSIIEAQNTKLNESNVQLEnktsclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQE---------- 1307
Cdd:COG1196  468 LLEEAALLEAALAELLEELAEAAARLLLLLE------AEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGveaayeaale 541

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1308 -------ANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKL-QQLEQAN 1379
Cdd:COG1196  542 aalaaalQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADArYYVLGDT 621

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1380 GELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEEtsKLAEQLSQLKQANEELQKSLQQK 1459
Cdd:COG1196  622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLE--AEAELEELAERLAEEELELEEAL 699

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574245 1460 QLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1533
Cdd:COG1196  700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLE 773
PTZ00121 PTZ00121
MAEBL; Provisional
 504-1324 2.44e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 82.50  E-value: 2.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   504 ESRIAEQLEEEQRLRENVKylneQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQ-AEFTRKLA 582
Cdd:PTZ00121 1086 DNRADEATEEAFGKAEEAK----KTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKrVEIARKAE 1161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   583 E-KSVEVLRLSSELQNLKATSDSLE---SERVNKTDEC----------------EILQTEVRMRDEQIR---------EL 633
Cdd:PTZ00121 1162 DaRKAEEARKAEDAKKAEAARKAEEvrkAEELRKAEDArkaeaarkaeeerkaeEARKAEDAKKAEAVKkaeeakkdaEE 1241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   634 NQQLDEVTTQLNVQKADSSALDDMLRLQKEG-TEEKSTLLEKTEKELVQSKEQAAKT--------LNDKEQLEKQISDLK 704
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIkAEEARKADELKKAEEKKKADEAKKAeekkkadeAKKKAEEAKKADEAK 1321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   705 QLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESGESLKKLQQ 782
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAkkKADAAKKKAEEKKKADEAKKKAE 1401

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   783 QLEQKTLGHEKLQAA---LEELKKEKETIIKEKEQELQQLQSKSAES--ESALKVVQVQLEQLQQQAAASGEEGSKTvAK 857
Cdd:PTZ00121 1402 EDKKKADELKKAAAAkkkADEAKKKAEEKKKADEAKKKAEEAKKADEakKKAEEAKKAEEAKKKAEEAKKADEAKKK-AE 1480

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   858 LHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGsleEEAKKSGHLLEQITKLKSEvgETQAALSSCHTDVESKTK 937
Cdd:PTZ00121 1481 EAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKA---EEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAE 1555

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   938 QLEAANaalEKVNKEYAESRAEASDLQDKVKEITDTLHaelQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEM 1017
Cdd:PTZ00121 1556 ELKKAE---EKKKAEEAKKAEEDKNMALRKAEEAKKAE---EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1018 LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKnlqEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQH 1097
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK---AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE 1706

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1098 KEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELK 1177
Cdd:PTZ00121 1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELD 1786

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1178 EthlqldERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQN 1257
Cdd:PTZ00121 1787 E------EDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNEN 1860

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245  1258 TKLNESNVQLENKTSCLKETQDQLLESqKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1324
Cdd:PTZ00121 1861 GEDGNKEADFNKEKDLKEDDEEEIEEA-DEIEKIDKDDIEREIPNNNMAGKNNDIIDDKLDKDEYIK 1926
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1282-1572 2.50e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.91  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1282 LESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK---VLEEKLQAATSQLDAQQATNKELQELLVKSQENE 1358
Cdd:COG1196  218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAelaELEAELEELRLELEELELELEEAQAEEYELLAEL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1359 GNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKL 1438
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1439 AEQLSQLKQANEELQKS-----------LQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETA 1507
Cdd:COG1196  378 EEELEELAEELLEALRAaaelaaqleelEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245 1508 LRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKI 1572
Cdd:COG1196  458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGL 522
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 369-979 4.34e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.14  E-value: 4.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  369 QDLLREKQQHVEKLmvERDldREDAQnQALQLQKNINELKA-----RIVELESALDNERKKTEELQCSIDEAQFCGDELN 443
Cdd:COG1196  192 EDILGELERQLEPL--ERQ--AEKAE-RYRELKEELKELEAellllKLRELEAELEELEAELEELEAELEELEAELAELE 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  444 AQSQVYKEKIHDLESKITklvsatpslqsilppdlpsddgALQEEIAKLQEkmtiQQKEVESRIAEQLEEEQRLRENVKY 523
Cdd:COG1196  267 AELEELRLELEELELELE----------------------EAQAEEYELLA----ELARLEQDIARLEERRRELEERLEE 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  524 LNEQIATLQSELVSKDEALEkfslsecgienlrrelelLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSD 603
Cdd:COG1196  321 LEEELAELEEELEELEEELE------------------ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  604 SLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSK 683
Cdd:COG1196  383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL 462

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  684 EQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQN-----ELEDFQKKQSESEVHLQE 758
Cdd:COG1196  463 ELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrglagAVAVLIGVEAAYEAALEA 542

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  759 IKAQNTQKDfeLVESGESLKKLQQQLEQKTLG------------HEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES 826
Cdd:COG1196  543 ALAAALQNI--VVEDDEVAAAAIEYLKAAKAGratflpldkiraRAALAAALARGAIGAAVDLVASDLREADARYYVLGD 620

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  827 ESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELkstQSNLEAKSKQLEAANGSLEEEAKKSGH 906
Cdd:COG1196  621 TLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRREL---LAALLEAEAELEELAERLAEEELELEE 697

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245  907 LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQ 979
Cdd:COG1196  698 ALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 569-1498 4.91e-15

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 81.25  E-value: 4.91e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    569 QAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQK 648
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQME 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    649 ADSSALDDMLRLQKEGTEEKSTLLE--------KTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENA 720
Cdd:TIGR00606  283 KDNSELELKMEKVFQGTDEQLNDLYhnhqrtvrEKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEH 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    721 INQIQLEKESIEQQLALKQNELEDFQKKQSESEVHL----QEIKAQNTQKDFELVESGESLKKlqqqlEQKTLGHEKLQA 796
Cdd:TIGR00606  363 IRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLvierQEDEAKTAAQLCADLQSKERLKQ-----EQADEIRDEKKG 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    797 ALEELKKEKETIIKEKEQ---ELQQLQSKSAESESALKVVQVQLEQLQQQAAAsgEEGSKTVAKLHDEISQLKSQAEETQ 873
Cdd:TIGR00606  438 LGRTIELKKEILEKKQEElkfVIKELQQLEGSSDRILELDQELRKAERELSKA--EKNSLTETLKKEVKSLQNEKADLDR 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    874 SELKSTQSNleAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDveskTKQLEAAnaaLEKVNKEY 953
Cdd:TIGR00606  516 KLRKLDQEM--EQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPN----KKQLEDW---LHSKSKEI 586

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    954 AESRAEASDLQDKVKEITDTLHAELQAERSsssaLHTKLSKFSDEI--ATGHKELTSKADAWSQEMLQKEKELQELRQQL 1031
Cdd:TIGR00606  587 NQTRDRLAKLNKELASLEQNKNHINNELES----KEEQLSSYEDKLfdVCGSQDEESDLERLKEEIEKSSKQRAMLAGAT 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1032 QDSQDSQTKLKAEgerkeksfEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIAD 1111
Cdd:TIGR00606  663 AVYSQFITQLTDE--------NQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPG 734

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1112 LKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfEMEADMNSERLIEKVTGIKEELKEthlQLDERQKKFE 1191
Cdd:TIGR00606  735 RQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLG--TIMPEEESAKVCLTDVTIMERFQM---ELKDVERKIA 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1192 ELEEKLKQA--QQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssiieaqntklnesnvqlen 1269
Cdd:TIGR00606  810 QQAAKLQGSdlDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNE--------------------- 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1270 ktscLKETQDQLLESQKKEKQLQEEAAKLSGElqqVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQE 1349
Cdd:TIGR00606  869 ----LKSEKLQIGTNLQRRQQFEEQLVELSTE---VQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1350 LLVKSQENEGNLQGESLAVTEKLQQLEQangelkEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKER 1429
Cdd:TIGR00606  942 KVNDIKEKVKNIHGYMKDIENKIQDGKD------DYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQER 1015

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245   1430 TLQEETS--KLAEQLSQLKQANEELQKSLQQKQLLLEKgnefdtqlAEYQKVIDEMDDAASVKSALLEQLQ 1498
Cdd:TIGR00606 1016 WLQDNLTlrKRENELKEVEEELKQHLKEMGQMQVLQMK--------QEHQKLEENIDLIKRNHVLALGRQK 1078
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1279-1597 5.16e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 81.26  E-value: 5.16e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1279 DQLLESQKKE-KQLQEEAAKLSGELQQVQEANG---DIKDSLVKVEELVKVLEEKLQAATSQldAQQAtnKELQELlvKS 1354
Cdd:TIGR02168  147 SEIIEAKPEErRAIFEEAAGISKYKERRKETERkleRTRENLDRLEDILNELERQLKSLERQ--AEKA--ERYKEL--KA 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1355 QENEGNLQGESLAVTEKLQQLEQANGELKEA---LCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTL 1431
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAeeeLEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1432 QEETSKLAEQLSQL----KQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETA 1507
Cdd:TIGR02168  301 EQQKQILRERLANLerqlEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1508 LRQANDAQKTAYLETKELRRQLESLELEKSRevlSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKND 1587
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLER---LEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELE 457

                          330
                   ....*....|
gi 28574245   1588 ALKAKVQTLE 1597
Cdd:TIGR02168  458 RLEEALEELR 467
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1015-1533 9.79e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 79.68  E-value: 9.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1015 QEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEevTKAKTENLELS-TGTQTTIKDLQERLEITNA 1093
Cdd:TIGR04523  117 EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYND--LKKQKEELENElNLLEKEKLNIQKNIDKIKN 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1094 ELQHKEKMASEDAQKIADLKTLVEAIqvanANISATNAELSTVLEVLQAEKSETNHIFElfemEADMNSERLIEKVTGIK 1173
Cdd:TIGR04523  195 KLLKLELLLSNLKKKIQKNKSLESQI----SELKKQNNQLKDNIEKKQQEINEKTTEIS----NTQTQLNQLKDEQNKIK 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1174 EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQtskeklteiQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1253
Cdd:TIGR04523  267 KQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKE---------QDWNKELKSELKNQEKKLEEIQNQISQNNKII 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1254 EAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAA 1333
Cdd:TIGR04523  338 SQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKL 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1334 TSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1413
Cdd:TIGR04523  418 QQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKE 497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1414 HNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKgNEFDTQLAEYQKVIDEMDDAasvksal 1493
Cdd:TIGR04523  498 LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNK-DDFELKKENLEKEIDEKNKE------- 569

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 28574245   1494 LEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1533
Cdd:TIGR04523  570 IEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKE 609
PTZ00121 PTZ00121
MAEBL; Provisional
 663-1371 2.24e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.41  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   663 EGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTE-NAINQIQLEKESIEQQLALKQNE 741
Cdd:PTZ00121 1080 DFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKaEDARKAEEARKAEDAKRVEIARK 1159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   742 LEDFQK----------KQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKEtiIKE 811
Cdd:PTZ00121 1160 AEDARKaeearkaedaKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE--AKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   812 KEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKtvAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLE 891
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARK--ADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK 1315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   892 AAngslEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEIT 971
Cdd:PTZ00121 1316 KA----DEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK 1391

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   972 DTLHAELQAERSSSSALHTK---LSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERK 1048
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKkaaAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1049 ---------EKSFEESIKNLQEEvTKAKTENLELSTGTQTTIKDLQERLEITNAElqhkEKMASEDAQKIADLKTLVEAI 1119
Cdd:PTZ00121 1472 adeakkkaeEAKKADEAKKKAEE-AKKKADEAKKAAEAKKKADEAKKAEEAKKAD----EAKKAEEAKKADEAKKAEEKK 1546

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1120 QVANANISATNAELSTVLEVLQAEKSETNHIFELFEME-ADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLK 1198
Cdd:PTZ00121 1547 KADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEeAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK 1626

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1199 QAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKlnesnvqlenktsclKETQ 1278
Cdd:PTZ00121 1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDE---------------KKAA 1691

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1279 DQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAAtSQLDAQQATNKELQELLVKSQENE 1358
Cdd:PTZ00121 1692 EALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKA-EEAKKDEEEKKKIAHLKKEEEKKA 1770

                         730
                  ....*....|...
gi 28574245  1359 GNLQGESLAVTEK 1371
Cdd:PTZ00121 1771 EEIRKEKEAVIEE 1783
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
853-1442 4.29e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 77.80  E-value: 4.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   853 KTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKsghlLEQITKLKSEVGETQAALSSCHTDV 932
Cdd:PRK03918  172 KEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREE----LEKLEKEVKELEELKEEIEELEKEL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   933 ESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITdtlhaELQAERSSSSALHTKLSKFSDEIATGHKELTSkada 1012
Cdd:PRK03918  248 ESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK-----ELKEKAEEYIKLSEFYEEYLDELREIEKRLSR---- 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1013 WSQEMLQKEKELQELRQQLQDSQDSQTKLKaEGERKEKSFEESIKNLQEevTKAKTENLE-----LSTGTQTTIKDLQER 1087
Cdd:PRK03918  319 LEEEINGIEERIKELEEKEERLEELKKKLK-ELEKRLEELEERHELYEE--AKAKKEELErlkkrLTGLTPEKLEKELEE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1088 LEITNAELQHKEK----MASEDAQKIADLKTLVEAIQVANANISATNAELS-----TVLEVLQAE-KSETNHIFELFEME 1157
Cdd:PRK03918  396 LEKAKEEIEEEISkitaRIGELKKEIKELKKAIEELKKAKGKCPVCGRELTeehrkELLEEYTAElKRIEKELKEIEEKE 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1158 ADMNSE-RLIEKVTGIKEEL---KETHLQLDERQKKFEELE-EKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSV 1232
Cdd:PRK03918  476 RKLRKElRELEKVLKKESELiklKELAEQLKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1233 KQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI 1312
Cdd:PRK03918  556 KKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEEL 635

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1313 KDSLVKVEELVKVLEEKLQAATsqldaqQATNKELQELLVKsqenegnLQGESLAVTEKLQQLEQANGELKEALCQKENG 1392
Cdd:PRK03918  636 AETEKRLEELRKELEELEKKYS------EEEYEELREEYLE-------LSRELAGLRAELEELEKRREEIKKTLEKLKEE 702

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 28574245  1393 LKELQGKLDESNtVLESQKKSHNEIQDKLE--QAQQKERTLQeETSKLAEQL 1442
Cdd:PRK03918  703 LEEREKAKKELE-KLEKALERVEELREKVKkyKALLKERALS-KVGEIASEI 752
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 625-1444 6.55e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.47  E-value: 6.55e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    625 MRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELvqskeQAAKTLNdkeqlEKQISDLK 704
Cdd:pfam15921  100 LHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHEL-----EAAKCLK-----EDMLEDSN 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    705 QLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNEledfqkKQSESEVHLQEIKAQNTQKDFELVESGESLK----KL 780
Cdd:pfam15921  170 TQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYE------HDSMSTMHFRSLGSAISKILRELDTEISYLKgrifPV 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    781 QQQLEQ-KTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLH 859
Cdd:pfam15921  244 EDQLEAlKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLE 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    860 DEISQLKSQAEETQselKSTQSNLEAKSKQLEAANGSLEEE-------AKKSGHLLEQITKLKSEVGETQAALSSCHTDV 932
Cdd:pfam15921  324 STVSQLRSELREAK---RMYEDKIEELEKQLVLANSELTEArterdqfSQESGNLDDQLQKLLADLHKREKELSLEKEQN 400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    933 ESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSdeiatghkELTSKADA 1012
Cdd:pfam15921  401 KRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVS--------SLTAQLES 472

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1013 wSQEMLQKEKElqelrqqlqdsqdSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLElstgtqttIKDLQERLEITN 1092
Cdd:pfam15921  473 -TKEMLRKVVE-------------ELTAKKMTLESSERTVSDLTASLQEKERAIEATNAE--------ITKLRSRVDLKL 530

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1093 AELQHkekmasedaqkiadLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGI 1172
Cdd:pfam15921  531 QELQH--------------LKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1173 KE------ELKETHLQLDERQKKFEELE--------EKLKQAQQSEQKLQQESQTSKEK---LTEIQQSLQELQDSVKQK 1235
Cdd:pfam15921  597 KEindrrlELQEFKILKDKKDAKIRELEarvsdlelEKVKLVNAGSERLRAVKDIKQERdqlLNEVKTSRNELNSLSEDY 676

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1236 EELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDS 1315
Cdd:pfam15921  677 EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEA 756

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1316 LVKVEELVKVLEEKLQAATSQLDA-QQATNKELQEL-LVKSQEN---------EGNLQGESLAVTE---KLQQLEQANGE 1381
Cdd:pfam15921  757 MTNANKEKHFLKEEKNKLSQELSTvATEKNKMAGELeVLRSQERrlkekvanmEVALDKASLQFAEcqdIIQRQEQESVR 836

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   1382 LKealCQKENGLKELQGKLDESNTVLE-------SQKKSHNEIQDK------LEQAQQKERTLQEETSKLAEQLSQ 1444
Cdd:pfam15921  837 LK---LQHTLDVKELQGPGYTSNSSMKprllqpaSFTRTHSNVPSSqstasfLSHHSRKTNALKEDPTRDLKQLLQ 909
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 629-1533 8.34e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 77.14  E-value: 8.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    629 QIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEK--TEKEL-VQSKEQAAKTLNDKEQLEKQISDLKQ 705
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQlqAETELcAEAEEMRARLAARKQELEEILHELES 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    706 LAEQEklvremtENAINQIQLEKESIEQQLAlkqneledfqkkqsESEVHLQEIKAQNTQKDFELVESGESLKKLQQQ-- 783
Cdd:pfam01576   83 RLEEE-------EERSQQLQNEKKKMQQHIQ--------------DLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDil 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    784 -LEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALkvvqVQLEQLQQQAAASGEEGSKTVAKLHDEI 862
Cdd:pfam01576  142 lLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMI----SDLEERLKKEEKGRQELEKAKRKLEGES 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    863 SQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQ---- 938
Cdd:pfam01576  218 TDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQrrdl 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    939 ---LEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQ 1015
Cdd:pfam01576  298 geeLEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEK 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1016 EMLQKEKELQELrqqlQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELstgtQTTIKDLQERLEITNAEL 1095
Cdd:pfam01576  378 AKQALESENAEL----QAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAEL----AEKLSKLQSELESVSSLL 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1096 QHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELfEMEADMNSERliekvtgikeE 1175
Cdd:pfam01576  450 NEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEE-EEEAKRNVER----------Q 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1176 LKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTE--------------IQQSLQELQDSVKQKEELVQN 1241
Cdd:pfam01576  519 LSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEkaaaydklektknrLQQELDDLLVDLDHQRQLVSN 598

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1242 LEEKVRESSSII---EAQNTKLNESNVQLENK-----------TSCLKETQDQLLESQKKEKQLQEE----------AAK 1297
Cdd:pfam01576  599 LEKKQKKFDQMLaeeKAISARYAEERDRAEAEareketralslARALEEALEAKEELERTNKQLRAEmedlvsskddVGK 678

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1298 LSGEL--------QQVQEANG---DIKDSLVKVEELVKVLEEKLQAATSQ----LDAQQATNKELQELLVKS-------Q 1355
Cdd:pfam01576  679 NVHELerskraleQQVEEMKTqleELEDELQATEDAKLRLEVNMQALKAQferdLQARDEQGEEKRRQLVKQvreleaeL 758

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1356 ENEGNLQGESLAVTEKLQ--------QLEQANGELKEALCQkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQK 1427
Cdd:pfam01576  759 EDERKQRAQAVAAKKKLEldlkeleaQIDAANKGREEAVKQ----LKKLQAQMKDLQRELEEARASRDEILAQSKESEKK 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1428 ERTLQEETSKLAEQLSQLKQAN-----------EELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE-------MDDAASV 1489
Cdd:pfam01576  835 LKNLEAELLQLQEDLAASERARrqaqqerdelaDEIASGASGKSALQDEKRRLEARIAQLEEELEEeqsntelLNDRLRK 914

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 28574245   1490 KSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1533
Cdd:pfam01576  915 STLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEME 958
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 868-1559 1.23e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 76.55  E-value: 1.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    868 QAEETQSELKSTQSNLEAKSKQLEAANgSLEEEAKKSGHLLEQITKLKSEVGETQAALsschtDVESKTKQLEAANAALE 947
Cdd:TIGR00618  230 HLREALQQTQQSHAYLTQKREAQEEQL-KKQQLLKQLRARIEELRAQEAVLEETQERI-----NRARKAAPLAAHIKAVT 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    948 KVNKEYAESRAEasdLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKEL-TSKADAWSQEMLQKEKELQE 1026
Cdd:TIGR00618  304 QIEQQAQRIHTE---LQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDaHEVATSIREISCQQHTLTQH 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1027 LRQQLQDSQDSQTKLKAEGERKEKsfeesiknLQEEVTKAKTENLELSTGTQ------TTIKDLQERLEITNA------- 1093
Cdd:TIGR00618  381 IHTLQQQKTTLTQKLQSLCKELDI--------LQREQATIDTRTSAFRDLQGqlahakKQQELQQRYAELCAAaitctaq 452

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1094 ELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSE--------TNHIFELFEMEADMNS-ER 1164
Cdd:TIGR00618  453 CEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPlcgscihpNPARQDIDNPGPLTRRmQR 532

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1165 LIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSvkqkeelvqnLEE 1244
Cdd:TIGR00618  533 GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDL----------TEK 602

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1245 KVRESSSIIEAQNTKLNESNVQLENktsclketQDQLLESQKKEKQLQEEAAKLSGELQQVqeANGDIKDSLVKVEELVK 1324
Cdd:TIGR00618  603 LSEAEDMLACEQHALLRKLQPEQDL--------QDVRLHLQQCSQELALKLTALHALQLTL--TQERVREHALSIRVLPK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1325 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:TIGR00618  673 ELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQA 752

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1405 TvlESQKKSHNEIQDKLEQAQQKERTLQEetsklaeqLSQLKQANEELQKSLQQKQLLLEkgnefdTQLAEYQKVIDEMD 1484
Cdd:TIGR00618  753 R--TVLKARTEAHFNNNEEVTAALQTGAE--------LSHLAAEIQFFNRLREEDTHLLK------TLEAEIGQEIPSDE 816

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245   1485 DAASVKSALL----EQLQNRVAELETALRQAndaqKTAYLETKELRRQLESLeLEKSREVLSLKAQMNGASSRSGKGDE 1559
Cdd:TIGR00618  817 DILNLQCETLvqeeEQFLSRLEEKSATLGEI----THQLLKYEECSKQLAQL-TQEQAKIIQLSDKLNGINQIKIQFDG 890
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1082-1544 1.71e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.87  E-value: 1.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1082 KDLQERLEITNAELQHKEK--MASEDAQ-KIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEmEA 1158
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKfiKRTENIEeLIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIE-EL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1159 DMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKlQQESQTSKEKLTEIQQSLQELQDSVKQKEEL 1238
Cdd:PRK03918  244 EKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEK-AEEYIKLSEFYEEYLDELREIEKRLSRLEEE 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1239 VQNLEEKVRESSSIiEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSG--------ELQQVQEANG 1310
Cdd:PRK03918  323 INGIEERIKELEEK-EERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGltpeklekELEELEKAKE 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1311 DIKDSLVKVEELVKVLEEK---LQAATSQLDAQQAT----NKELQEllvksqENEGNLQGEslaVTEKLQQLEQANGELK 1383
Cdd:PRK03918  402 EIEEEISKITARIGELKKEikeLKKAIEELKKAKGKcpvcGRELTE------EHRKELLEE---YTAELKRIEKELKEIE 472

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1384 EALCQKENGLKELQGKLDESNTV------------LESQKKSHNeiQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEE 1451
Cdd:PRK03918  473 EKERKLRKELRELEKVLKKESELiklkelaeqlkeLEEKLKKYN--LEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEK 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1452 LQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAAsvksalLEQLQNRVAELETALRQANDAQKTAY-LETKELRRQLE 1530
Cdd:PRK03918  551 LEELKKKLAELEKKLDELEEELAELLKELEELGFES------VEELEERLKELEPFYNEYLELKDAEKeLEREEKELKKL 624

                         490
                  ....*....|....
gi 28574245  1531 SLELEKSREVLSLK 1544
Cdd:PRK03918  625 EEELDKAFEELAET 638
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
654-1248 2.69e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.10  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   654 LDDMLRLQKEGTEEKSTLLEKTE------KELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLE 727
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTEnieeliKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   728 KESIEQQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELkkek 805
Cdd:PRK03918  247 LESLEGSKRKLEEKIRELEERIEELKKEIEELeeKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEE---- 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   806 etiIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQaaasgeegsKTVAKLHDEISQLKSQAEETQSELKS-TQSNLE 884
Cdd:PRK03918  323 ---INGIEERIKELEEKEERLEELKKKLKELEKRLEEL---------EERHELYEEAKAKKEELERLKKRLTGlTPEKLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   885 AKSKQLEAANGSLEEEAKKsghLLEQITKLKSEVGETQAALSS-------CHT-----DVESKTKQLEAANAALEKVNKE 952
Cdd:PRK03918  391 KELEELEKAKEEIEEEISK---ITARIGELKKEIKELKKAIEElkkakgkCPVcgrelTEEHRKELLEEYTAELKRIEKE 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   953 YAESRAEASDLQDKVKEITDTLHAELQAerssssalhTKLSKFSDEIatghKELTSKADAWSQEML-QKEKELQELRQQL 1031
Cdd:PRK03918  468 LKEIEEKERKLRKELRELEKVLKKESEL---------IKLKELAEQL----KELEEKLKKYNLEELeKKAEEYEKLKEKL 534

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1032 QDSQDSQTKLKAEGERKE------KSFEESIKNLQEEVTKAKTENLELSTGtqtTIKDLQERLEitNAELQHKEKMASED 1105
Cdd:PRK03918  535 IKLKGEIKSLKKELEKLEelkkklAELEKKLDELEEELAELLKELEELGFE---SVEELEERLK--ELEPFYNEYLELKD 609

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1106 AQKiaDLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFemeadmnSERLIEKVTGIKEELKETHLQLDE 1185
Cdd:PRK03918  610 AEK--ELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKY-------SEEEYEELREEYLELSRELAGLRA 680

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245  1186 RqkkFEELEEKLKQAQQSEQKLqqesqtsKEKLTEIQQSLQELQDSVKQKEElVQNLEEKVRE 1248
Cdd:PRK03918  681 E---LEELEKRREEIKKTLEKL-------KEELEEREKAKKELEKLEKALER-VEELREKVKK 732
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
653-1243 3.10e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.08  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   653 ALDDMLRLQKEGTEE-KSTLLEKTEKELVqskeqaaKTLNDKEQLEKQI-SDLKQLAEQEKLVREMTENAINQIQLEKES 730
Cdd:PRK02224  177 GVERVLSDQRGSLDQlKAQIEEKEEKDLH-------ERLNGLESELAELdEEIERYEEQREQARETRDEADEVLEEHEER 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   731 IEQQLALKQnELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIK 810
Cdd:PRK02224  250 REELETLEA-EIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRD 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   811 EKEQELQQLQSKSAESESALKVVQVQLEQLqqqaaasgeegsktvAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQL 890
Cdd:PRK02224  329 RLEECRVAAQAHNEEAESLREDADDLEERA---------------EELREEAAELESELEEAREAVEDRREEIEELEEEI 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   891 EAANGS-------LEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDL 963
Cdd:PRK02224  394 EELRERfgdapvdLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIEED 473

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   964 QDKVKEITDTLhAELQAERSSSSALHTKLSKFSdEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKA 1043
Cdd:PRK02224  474 RERVEELEAEL-EDLEEEVEEVEERLERAEDLV-EAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEA 551

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1044 EGERKEKSFEESIKNLQEevtkaktenlelstgTQTTIKDLQERLEITNAELQHKEKMASEDAqKIADLKTLVEAIQVAN 1123
Cdd:PRK02224  552 EAEEKREAAAEAEEEAEE---------------AREEVAELNSKLAELKERIESLERIRTLLA-AIADAEDEIERLREKR 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1124 ANISATNAELSTVLevlqAEKSETNHifelfEMEADMNSERLiekvtgikEELKETHLQLDERQkkfEELEEKLKQAQQS 1203
Cdd:PRK02224  616 EALAELNDERRERL----AEKRERKR-----ELEAEFDEARI--------EEAREDKERAEEYL---EQVEEKLDELREE 675

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 28574245  1204 EQKLQQESQTSKEKLTEiqqsLQELQDSVKQKEELVQNLE 1243
Cdd:PRK02224  676 RDDLQAEIGAVENELEE----LEELRERREALENRVEALE 711
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 397-1300 3.36e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 75.01  E-value: 3.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    397 ALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDEL-NAQSQVYKEKIHDLESKITKLVSATPSLQSIL- 474
Cdd:pfam02463  182 TENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLyLDYLKLNEERIDLLQELLRDEQEEIESSKQEIe 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    475 -PPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIE 553
Cdd:pfam02463  262 kEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    554 NLRRELELLKEENEKQAQEAQAEftrklaeksvevLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIREL 633
Cdd:pfam02463  342 KELKELEIKREAEEEEEEELEKL------------QEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    634 NQQLdevttqLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLV 713
Cdd:pfam02463  410 LLEL------ARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    714 REMTEnainQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKT----- 788
Cdd:pfam02463  484 EQLEL----LLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSatade 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    789 -LGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES-------ESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHD 860
Cdd:pfam02463  560 vEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidpilnlAQLDKATLEADEDDKRAKVVEGILKDTELTKLKE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    861 EISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSScHTDVESKTKQLE 940
Cdd:pfam02463  640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQ-REKEELKKLKLE 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    941 AANAALEKVNKEYAESRAEASDLQDKVKEITDTlhaELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK 1020
Cdd:pfam02463  719 AEELLADRVQEAQDKINEELKLLKQKIDEEEEE---EEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEK 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1021 EKELQELRQQLQDsqdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEK 1100
Cdd:pfam02463  796 LKAQEEELRALEE------ELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELL 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1101 MASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfemeadmnsERLIEKVTGIKEELKETH 1180
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEE----------RIKEEAEILLKYEEEPEE 939

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1181 LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKL 1260
Cdd:pfam02463  940 LLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRL 1019

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|
gi 28574245   1261 NESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSG 1300
Cdd:pfam02463 1020 KEFLELFVSINKGWNKVFFYLELGGSAELRLEDPDDPFSG 1059
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 363-1023 5.34e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 74.38  E-value: 5.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    363 KSQFSMQDLLREKQQHVEKLMVERD----LDREDAQNQA---LQLQKNINELKARIVELESALDNERKKTEELQ------ 429
Cdd:pfam15921  103 KQKFYLRQSVIDLQTKLQEMQMERDamadIRRRESQSQEdlrNQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRkmmlsh 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    430 ---------CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTI-- 498
Cdd:pfam15921  183 egvlqeirsILVDFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELll 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    499 --QQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSEL-VSKDEALEKFSLSECGIENLRRELELLKEenekQAQEAQA 575
Cdd:pfam15921  263 qqHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLeIIQEQARNQNSMYMRQLSDLESTVSQLRS----ELREAKR 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    576 EFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQI---RELNQQL-----------DEVT 641
Cdd:pfam15921  339 MYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELsleKEQNKRLwdrdtgnsitiDHLR 418

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    642 TQLNVQKADSSALDDMLRLQKE----GTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLK----QLAEQEKLV 713
Cdd:pfam15921  419 RELDDRNMEVQRLEALLKAMKSecqgQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTakkmTLESSERTV 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    714 REMT------ENAINQIQLEKESIEQQLALKQNELEDFQKKQSesevHLQEIKAQNTQKDFELVESGESLKKLQQQLEQK 787
Cdd:pfam15921  499 SDLTaslqekERAIEATNAEITKLRSRVDLKLQELQHLKNEGD----HLRNVQTECEALKLQMAEKDKVIEILRQQIENM 574

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    788 TL---GHEKLQAALEELKKEKETIIKEKEQELQQ---LQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDE 861
Cdd:pfam15921  575 TQlvgQHGRTAGAMQVEKAQLEKEINDRRLELQEfkiLKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQE 654

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    862 ISQLKSQAEETQSELKS-------TQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQI-TKLKSEVGETQAALS---SCHT 930
Cdd:pfam15921  655 RDQLLNEVKTSRNELNSlsedyevLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTrNTLKSMEGSDGHAMKvamGMQK 734

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    931 DVESKTKQLEAANA-------ALEKVNKEYAESRAEASDLQDKVKEIT---DTLHAELQAERSSSSALHTKLSKFsdEIA 1000
Cdd:pfam15921  735 QITAKRGQIDALQSkiqfleeAMTNANKEKHFLKEEKNKLSQELSTVAtekNKMAGELEVLRSQERRLKEKVANM--EVA 812

                          730       740
                   ....*....|....*....|...
gi 28574245   1001 TGHKELTSkadAWSQEMLQKEKE 1023
Cdd:pfam15921  813 LDKASLQF---AECQDIIQRQEQ 832
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
384-969 1.38e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.79  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   384 VERDLDREDAQNQALQLQKNINELKARIVELESALdnerKKTEELQCSIDEAqfcGDELNAQSQVYKE---KIHDLESKI 460
Cdd:PRK03918  151 VRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFI----KRTENIEELIKEK---EKELEEVLREINEissELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   461 TKLVSATPSLQSI--LPPDLPSDDGALQEEIAKLQEKMtiqqKEVESRIAEQLEEEQRLRENVKYLNEqiatlQSELVSK 538
Cdd:PRK03918  224 EKLEKEVKELEELkeEIEELEKELESLEGSKRKLEEKI----RELEERIEELKKEIEELEEKVKELKE-----LKEKAEE 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   539 DEALEKFslsecgienlrrelellkeenekqaqeaQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLEServnktdecei 618
Cdd:PRK03918  295 YIKLSEF----------------------------YEEYLDELREIEKRLSRLEEEINGIEERIKELEE----------- 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   619 lqtevrmRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTL----LEKTEKELVQSKEQAAKTLNDKE 694
Cdd:PRK03918  336 -------KEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLtgltPEKLEKELEELEKAKEEIEEEIS 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   695 QLEKQISDLKQLAEQEKLV---------------REMTE----NAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVH 755
Cdd:PRK03918  409 KITARIGELKKEIKELKKAieelkkakgkcpvcgRELTEehrkELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKV 488

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   756 LQEIKAQNTQKDF--ELVESGESLKKLQ-QQLEQKTLGHEKLQAALEELKKEKETIIKEKEqELQQLQSKSAESESALKV 832
Cdd:PRK03918  489 LKKESELIKLKELaeQLKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEIKSLKKELE-KLEELKKKLAELEKKLDE 567

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   833 VQVQLEQLQQQAaasGEEGSKTVAKLHDEISQLKSQAEEtQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQIT 912
Cdd:PRK03918  568 LEEELAELLKEL---EELGFESVEELEERLKELEPFYNE-YLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245   913 KLKSEVGETQAALS-SCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKE 969
Cdd:PRK03918  644 ELRKELEELEKKYSeEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE 701
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 367-1092 1.75e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 72.36  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    367 SMQDLLREKQQHVEKLMVERDLDREDAQNqalqLQKNINELKARIVELESALDNERKKTEELQCSIdeaqfcgDELNAQS 446
Cdd:TIGR04523   44 TIKNELKNKEKELKNLDKNLNKDEEKINN----SNNKIKILEQQIKDLNDKLKKNKDKINKLNSDL-------SKINSEI 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    447 QVYKEKIHDLESKITKLvsatpslqsilppdlpsddgalqeeiaklqEKmtiQQKEVESRIAEQLEEEQRLRENVKYLNE 526
Cdd:TIGR04523  113 KNDKEQKNKLEVELNKL------------------------------EK---QKKENKKNIDKFLTEIKKKEKELEKLNN 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    527 QIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKqaqeaqaeFTRKLAEKSVEVLRLSSELQNLKATSDSLE 606
Cdd:TIGR04523  160 KYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLEL--------LLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    607 SERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLN-----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQ 681
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSekqkeLEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    682 SKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKkqsESEVHLQEIKA 761
Cdd:TIGR04523  312 LKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKK---ENQSYKQEIKN 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    762 QNTQKdfelvesgeslKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEkEQELQQLQSKSAESESALKVVQVQLEqlq 841
Cdd:TIGR04523  389 LESQI-----------NDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKE-IERLKETIIKNNSEIKDLTNQDSVKE--- 453

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    842 qqaaasgeegsKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVG-- 919
Cdd:TIGR04523  454 -----------LIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISsl 522

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    920 -ETQAALSSCHTDVESKTKQLEAanaalEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDE 998
Cdd:TIGR04523  523 kEKIEKLESEKKEKESKISDLED-----ELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKE 597

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    999 IatghKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAegerKEKSFEESIKNLQEEVTKAKTENLELSTGTQ 1078
Cdd:TIGR04523  598 K----KDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKS----KKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669

                          730
                   ....*....|....
gi 28574245   1079 TTIKDLQERLEITN 1092
Cdd:TIGR04523  670 ESKTKIDDIIELMK 683
PRK11281 PRK11281
mechanosensitive channel MscK;
1172-1548 1.75e-12

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 72.64  E-value: 1.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1172 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQesqtskeklteIQQSLQELQDSvkQKEELVQNLeekvrESSS 1251
Cdd:PRK11281   61 VQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQ-----------AQAELEALKDD--NDEETRETL-----STLS 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1252 IIEAQNtKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQeeaAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQ 1331
Cdd:PRK11281  123 LRQLES-RLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQ---AALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLLQ 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1332 AATSQLDAQQ-------ATNKELQELLvKSQENEgnlqgeslaVTEKLQQLEQANGELKEALCQKEngLKELQGKLDESN 1404
Cdd:PRK11281  199 AEQALLNAQNdlqrkslEGNTQLQDLL-QKQRDY---------LTARIQRLEHQLQLLQEAINSKR--LTLSEKTVQEAQ 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1405 TVLESQKKSHNE-IQDKLEQAQQKERTLQEETSKLAE----------QLSQLKQAN---EE----LQKSL-------QQK 1459
Cdd:PRK11281  267 SQDEAARIQANPlVAQELEINLQLSQRLLKATEKLNTltqqnlrvknWLDRLTQSErniKEqisvLKGSLllsrilyQQQ 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1460 QLL--LEKGNEFDTQLAE---YQKVIDEMDDAasvksalLEQLQNRVAELEtalrqANDAQKtaylETKELRRQLESLeL 1534
Cdd:PRK11281  347 QALpsADLIEGLADRIADlrlEQFEINQQRDA-------LFQPDAYIDKLE-----AGHKSE----VTDEVRDALLQL-L 409

                         410
                  ....*....|....*....
gi 28574245  1535 EKSREVL-----SLKAQMN 1548
Cdd:PRK11281  410 DERRELLdqlnkQLNNQLN 428
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1015-1579 3.49e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 71.63  E-value: 3.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1015 QEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEEsIKNLQEEVTKAKTENLELstgtQTTIKDLQERLEITNAE 1094
Cdd:PRK03918  200 KELEEVLREINEISSELPELREELEKLEKEVKELEELKEE-IEELEKELESLEGSKRKL----EEKIRELEERIEELKKE 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1095 LQHKEKMASE------DAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNhifelfemeadmNSERLIEK 1168
Cdd:PRK03918  275 IEELEEKVKElkelkeKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE------------EKEERLEE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1169 VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESqtskekLTEIQQSLQELQDSVKQKEELVQNLEEKVRE 1248
Cdd:PRK03918  343 LKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLT------PEKLEKELEELEKAKEEIEEEISKITARIGE 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1249 SSSIIEAQNTKLNESNVQ-------------------LENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEAN 1309
Cdd:PRK03918  417 LKKEIKELKKAIEELKKAkgkcpvcgrelteehrkelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELI 496

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1310 gdikdSLVKVEELVKVLEEKLQAAtsQLDAQQATNKELQELLVKSQENEGNLQGESLAVtEKLQQLEQANGELKEALCQK 1389
Cdd:PRK03918  497 -----KLKELAEQLKELEEKLKKY--NLEELEKKAEEYEKLKEKLIKLKGEIKSLKKEL-EKLEELKKKLAELEKKLDEL 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1390 ENGLKELQGKLDE----SNTVLESQ--------------KKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEE 1451
Cdd:PRK03918  569 EEELAELLKELEElgfeSVEELEERlkelepfyneylelKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKE 648

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1452 LQkslqqkqlllEKGNEFDTQlaEYQKVIDEMddaasvksallEQLQNRVAELETALRQANDAQKTAYLETKELRRQLES 1531
Cdd:PRK03918  649 LE----------ELEKKYSEE--EYEELREEY-----------LELSRELAGLRAELEELEKRREEIKKTLEKLKEELEE 705

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 28574245  1532 LElEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSII 1579
Cdd:PRK03918  706 RE-KAKKELEKLEKALERVEELREKVKKYKALLKERALSKVGEIASEI 752
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 622-984 3.82e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.64  E-value: 3.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    622 EVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAaktlndkEQLEKQIS 701
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERL-------EELEEDLS 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    702 DLKQlaEQEKLVREMTENAinqiqLEKESIEQQLALKQNELEDFQKKQSESEVhlQEIKAQNTQKDFELVESGESLKKLQ 781
Cdd:TIGR02169  748 SLEQ--EIENVKSELKELE-----ARIEELEEDLHKLEEALNDLEARLSHSRI--PEIQAELSKLEEEVSRIEARLREIE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    782 QQLEQKTLGHEKLQAALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKL 858
Cdd:TIGR02169  819 QKLNRLTLEKEYLEKEIQELQEQRIDLkeqIKSIEKEIENLNGKKEELEEEL------------------EELEAALRDL 880

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    859 HDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHT--DVESKT 936
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSleDVQAEL 960

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 28574245    937 KQLEAANAALEKVN----KEYAESRAEASDLQDKvkeitdtlHAELQAERSS 984
Cdd:TIGR02169  961 QRVEEEIRALEPVNmlaiQEYEEVLKRLDELKEK--------RAKLEEERKA 1004
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 805-1535 4.49e-12

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 71.36  E-value: 4.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    805 KETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQqqaaasgEEGSKTVAKLHDEiSQLKSQAEETQSELKSTQSNLE 884
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLC-------EEKNALQEQLQAE-TELCAEAEEMRARLAARKQELE 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    885 AKSKQLEAangSLEEEAKKSGHLL-------EQITKLKSEVGETQAALSSCHTD---VESKTKQLEAANAALEKVNKEYA 954
Cdd:pfam01576   75 EILHELES---RLEEEEERSQQLQnekkkmqQHIQDLEEQLDEEEAARQKLQLEkvtTEAKIKKLEEDILLLEDQNSKLS 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    955 EsraEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAwSQEMLQKEKELQELRQQLQDS 1034
Cdd:pfam01576  152 K---ERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQEL-EKAKRKLEGESTDLQEQIAEL 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1035 QDSQTKLKAEGERKEKSFEESIKNLQEEvTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKT 1114
Cdd:pfam01576  228 QAQIAELRAQLAKKEEELQAALARLEEE-TAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKT 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1115 LVEAIQvanaNISATNAELSTVLEvlqaekSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLdERQKKFEELE 1194
Cdd:pfam01576  307 ELEDTL----DTTAAQQELRSKRE------QEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQL-EQAKRNKANL 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1195 EKLKQAQQSEQK--------LQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQ 1266
Cdd:pfam01576  376 EKAKQALESENAelqaelrtLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGK 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1267 LENKTSCLKETQDQLLESQKkekQLQEEAA---KLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAT 1343
Cdd:pfam01576  456 NIKLSKDVSSLESQLQDTQE---LLQEETRqklNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1344 NKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELkealcqkENGLKELQGKLDESNTVLESQKkshnEIQDKLEQ 1423
Cdd:pfam01576  533 LEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKL-------EKTKNRLQQELDDLLVDLDHQR----QLVSNLEK 601

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1424 AQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKgnefdtQLAEYQKVIDEMDDAASVKSALLEQLQNRVAE 1503
Cdd:pfam01576  602 KQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLAR------ALEEALEAKEELERTNKQLRAEMEDLVSSKDD 675

                          730       740       750
                   ....*....|....*....|....*....|..
gi 28574245   1504 LETALRQANDAQKTAYLETKELRRQLESLELE 1535
Cdd:pfam01576  676 VGKNVHELERSKRALEQQVEEMKTQLEELEDE 707
mukB PRK04863
chromosome partition protein MukB;
1164-1538 4.67e-12

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 71.53  E-value: 4.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1164 RLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQElqdsvkqkeelvQNLE 1243
Cdd:PRK04863  283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQ------------QEKI 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1244 EKVRESssiieaqntkLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEAngdikdslvkveelv 1323
Cdd:PRK04863  351 ERYQAD----------LEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQA--------------- 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1324 kvleeklqaatsqLDAQQATNKELQELLVKSQENEGNLQGESLAVT---EKLQQLEQANGELKEALCQKENGLKELQGKL 1400
Cdd:PRK04863  406 -------------LDVQQTRAIQYQQAVQALERAKQLCGLPDLTADnaeDWLEEFQAKEQEATEELLSLEQKLSVAQAAH 472

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1401 DESNTVLESQKKSHNEI--QDKLEQAQQKERTLQEEtSKLAEQLSQLKQANEELQKSLQQKQLLLEkgnefdtQLAEYQK 1478
Cdd:PRK04863  473 SQFEQAYQLVRKIAGEVsrSEAWDVARELLRRLREQ-RHLAEQLQQLRMRLSELEQRLRQQQRAER-------LLAEFCK 544

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1479 VIDEMDDAAsvksALLEQLQnrvAELETALRQANDAQKTAYLETKELRRQLESLELEKSR 1538
Cdd:PRK04863  545 RLGKNLDDE----DELEQLQ---EELEARLESLSESVSEARERRMALRQQLEQLQARIQR 597
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 728-1460 8.71e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 70.53  E-value: 8.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    728 KESIEQQLALKQNELEDFQKKQSES-EVH-----------------LQEIKAQ-NTQKDFELVESgESLKKLQQQLEQKT 788
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQRRLNESnELHekqkfylrqsvidlqtkLQEMQMErDAMADIRRRES-QSQEDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    789 LGHEKLQAALEELKKEKETIIKE-------KEQELQQLQSKSAESESAL-KVVQVQLEQLQQQAAASGEEGSKTVAKLHD 860
Cdd:pfam15921  152 HELEAAKCLKEDMLEDSNTQIEQlrkmmlsHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLGSAISKILRELDT 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    861 EISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAkKSGHLLEqITKLKSEVGETQAALSSCHTDVESKTKQLE 940
Cdd:pfam15921  232 EISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQL-ISEHEVE-ITGLTEKASSARSQANSIQSQLEIIQEQAR 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    941 AANAAL--------EKVNKEYAESRAEASDLQDKVKEITDTL---HAELQAERS-------SSSALHTKLSKFSDEIATG 1002
Cdd:pfam15921  310 NQNSMYmrqlsdleSTVSQLRSELREAKRMYEDKIEELEKQLvlaNSELTEARTerdqfsqESGNLDDQLQKLLADLHKR 389

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1003 HKELTSKADA----WSQEM---LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQeevtkAKTENLELST 1075
Cdd:pfam15921  390 EKELSLEKEQnkrlWDRDTgnsITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQ-----GKNESLEKVS 464

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1076 GTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVE----AIQVANANISATNAELSTVLEVLQAEKSETNHIf 1151
Cdd:pfam15921  465 SLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQekerAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL- 543

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1152 elfemeadmnserliekvTGIKEELKETHLQLDERQKKFEELEEKLKQAQQ-------SEQKLQQESQTSKEKLTEIQQS 1224
Cdd:pfam15921  544 ------------------RNVQTECEALKLQMAEKDKVIEILRQQIENMTQlvgqhgrTAGAMQVEKAQLEKEINDRRLE 605

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1225 LQELQDSVKQKEELVQNLEEKVressSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQlqeEAAKLSGELQQ 1304
Cdd:pfam15921  606 LQEFKILKDKKDAKIRELEARV----SDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRN---ELNSLSEDYEV 678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1305 VQEangDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQ-------ELLVKSQENEGNLQGESLAVTEKLQQLEQ 1377
Cdd:pfam15921  679 LKR---NFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEgsdghamKVAMGMQKQITAKRGQIDALQSKIQFLEE 755

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1378 ANGELKealcQKENGLKELQGKLDESNTVLESQKkshNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQ 1457
Cdd:pfam15921  756 AMTNAN----KEKHFLKEEKNKLSQELSTVATEK---NKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQ 828


                   ...
gi 28574245   1458 QKQ 1460
Cdd:pfam15921  829 RQE 831
PTZ00121 PTZ00121
MAEBL; Provisional
 937-1555 8.98e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 70.56  E-value: 8.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   937 KQLEAANAAlEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIAT--GHKELTSKAD-AW 1013
Cdd:PTZ00121 1200 RKAEAARKA-EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAhfARRQAAIKAEeAR 1278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1014 SQEMLQKEKELQ---ELRQQLQDSQDSQTKLKAEGERKE---KSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQER 1087
Cdd:PTZ00121 1279 KADELKKAEEKKkadEAKKAEEKKKADEAKKKAEEAKKAdeaKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADE 1358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1088 LEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAE---------KSETNHIFELFEMEA 1158
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAaakkkadeaKKKAEEKKKADEAKK 1438

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1159 DMNSERLIEKVTGIKEELK--ETHLQLDERQKKFEELEEKLKQAQQSEQkLQQESQTSKEKLTEIQQSLQELQ--DSVKQ 1234
Cdd:PTZ00121 1439 KAEEAKKADEAKKKAEEAKkaEEAKKKAEEAKKADEAKKKAEEAKKADE-AKKKAEEAKKKADEAKKAAEAKKkaDEAKK 1517

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1235 KEELVQNLE-EKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIK 1313
Cdd:PTZ00121 1518 AEEAKKADEaKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1314 DSLVKVEELVKVlEEKLQAATSQLDAQQATNKELQEllvKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKEngl 1393
Cdd:PTZ00121 1598 MKLYEEEKKMKA-EEAKKAEEAKIKAEELKKAEEEK---KKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA--- 1670

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1394 KELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKE--RTLQEETSKLAEQL-----------SQLKQANEELQKSLQQKQ 1460
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEelKKKEAEEKKKAEELkkaeeenkikaEEAKKEAEEDKKKAEEAK 1750

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1461 LLLEKGNEFDTQLAEYQKVIDEM--DDAASVKSALLEQLQNRVAELETALRQA------------------NDAQKTAYL 1520
Cdd:PTZ00121 1751 KDEEEKKKIAHLKKEEEKKAEEIrkEKEAVIEEELDEEDEKRRMEVDKKIKDIfdnfaniieggkegnlviNDSKEMEDS 1830

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 28574245  1521 ETKELRRQlESLELEKSREVLSLKAQMNGASSRSG 1555
Cdd:PTZ00121 1831 AIKEVADS-KNMQLEEADAFEKHKFNKNNENGEDG 1864
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1131-1592 1.01e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 70.07  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1131 AELSTVLEVLQAEKSETNHIFELFEMEADMNSERLiEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQE 1210
Cdd:PRK02224  202 KDLHERLNGLESELAELDEEIERYEEQREQARETR-DEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1211 SQTSKEKLTEIQQSLQEL----------QDSVKQKEELVQNLEEKVRESssiIEAQNTKLNESNVQLENktscLKETQDQ 1280
Cdd:PRK02224  281 VRDLRERLEELEEERDDLlaeaglddadAEAVEARREELEDRDEELRDR---LEECRVAAQAHNEEAES----LREDADD 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1281 LlESQKKEkqLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQEllvksqenegn 1360
Cdd:PRK02224  354 L-EERAEE--LREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELRE----------- 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1361 lqgESLAVTEKLQQLEqanGELKEAlcqkENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAE 1440
Cdd:PRK02224  420 ---ERDELREREAELE---ATLRTA----RERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEE 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1441 QLSQLKQ---ANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAAsvksallEQLQNRVAELETALRQANDAQKT 1517
Cdd:PRK02224  490 EVEEVEErleRAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERA-------EELRERAAELEAEAEEKREAAAE 562

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245  1518 AYLETKELRRQLESLEleksrevlslkaqmngaSSRSGKGDEVESLD-IETSLAKINFLNSIIADMQQKNDALKAK 1592
Cdd:PRK02224  563 AEEEAEEAREEVAELN-----------------SKLAELKERIESLErIRTLLAAIADAEDEIERLREKREALAEL 621
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1255-1515 1.23e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 68.64  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1255 AQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAAT 1334
Cdd:COG4942   17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1335 SQLDAQQatnKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEalcqkenglkelqgkldesntVLESQKKSH 1414
Cdd:COG4942   97 AELEAQK---EELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKY---------------------LAPARREQA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1415 NEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLekgNEFDTQLAEYQKVIDEMDDAASVKSALL 1494
Cdd:COG4942  153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLL---ARLEKELAELAAELAELQQEAEELEALI 229

                        250       260
                 ....*....|....*....|.
gi 28574245 1495 EQLQNRVAELETALRQANDAQ 1515
Cdd:COG4942  230 ARLEAEAAAAAERTPAAGFAA 250
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 358-1063 1.66e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 69.71  E-value: 1.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    358 ILATPKSQFSMQDLLREKQQHV-EKLMVERDLDREDAQNQalQLQKNINELKARIVELESALDNERKKTEELQcsideaq 436
Cdd:TIGR02169  215 ALLKEKREYEGYELLKEKEALErQKEAIERQLASLEEELE--KLTEEISELEKRLEEIEQLLEELNKKIKDLG------- 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    437 fcGDELNAqsqvYKEKIHDLESKITKLVSATPSLQSILP------PDLPSDDGALQEEIAKLQEKMTIQQKEVES---RI 507
Cdd:TIGR02169  286 --EEEQLR----VKEKIGELEAEIASLERSIAEKERELEdaeerlAKLEAEIDKLLAEIEELEREIEEERKRRDKlteEY 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    508 AEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLA----- 582
Cdd:TIGR02169  360 AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAkinel 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    583 --EKSVEVLRLSSELQNLKATSDSLESERvnktDECEILQTEVRMRDEQIRELNQQLDEVTTQLNV---QKADSSALDDM 657
Cdd:TIGR02169  440 eeEKEDKALEIKKQEWKLEQLAADLSKYE----QELYDLKEEYDRVEKELSKLQRELAEAEAQARAseeRVRGGRAVEEV 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    658 LRLQKEGTEEKSTLLEKTEKELVQSKEQAAK------TLNDKEQLEKQIsdlkQLAEQEKLVReMTENAINQIQ-----L 726
Cdd:TIGR02169  516 LKASIQGVHGTVAQLGSVGERYATAIEVAAGnrlnnvVVEDDAVAKEAI----ELLKRRKAGR-ATFLPLNKMRderrdL 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    727 EKESIEQQLALKQNeLEDFQKK---------------QSESEVHLQEIKAQNTQKDFELVE-----SGESLKKLQQQLEQ 786
Cdd:TIGR02169  591 SILSEDGVIGFAVD-LVEFDPKyepafkyvfgdtlvvEDIEAARRLMGKYRMVTLEGELFEksgamTGGSRAPRGGILFS 669

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    787 KTLGHE--KLQAALEELKKEKETIIKEK---EQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEgsktVAKLHDE 861
Cdd:TIGR02169  670 RSEPAElqRLRERLEGLKRELSSLQSELrriENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER----LEELEED 745

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    862 ISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEE-EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLE 940
Cdd:TIGR02169  746 LSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLT 825

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    941 AANAALEKvnkEYAESRAEASDLQDKVKEITDTLHaELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK 1020
Cdd:TIGR02169  826 LEKEYLEK---EIQELQEQRIDLKEQIKSIEKEIE-NLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLREL 901

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*.
gi 28574245   1021 EKELQELRQQLQDSQDSQTKLKAEGERKE---KSFEESIKNLQEEV 1063
Cdd:TIGR02169  902 ERKIEELEAQIEKKRKRLSELKAKLEALEeelSEIEDPKGEDEEIP 947
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1326-1553 1.95e-11

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 68.89  E-value: 1.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1326 LEEKLQAATSQLDAQQAtnkELQELlvKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNT 1405
Cdd:COG3206  180 LEEQLPELRKELEEAEA---ALEEF--RQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1406 VLESQKKShNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQlllekgnefdtqlAEYQKVIDEMDD 1485
Cdd:COG3206  255 ALPELLQS-PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQ-------------QEAQRILASLEA 320

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1486 AASVKSALLEQLQNRVAELETALRQANDAQKtaylETKELRRQLESLE-----LEKSREVLSLKAQMNGASSR 1553
Cdd:COG3206  321 ELEALQAREASLQAQLAQLEARLAELPELEA----ELRRLEREVEVARelyesLLQRLEEARLAEALTVGNVR 389
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
514-1069 2.41e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.94  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   514 EQRLRENVKYLNEQIatlqselvskdEALEKFSLSECGIENLRRELELLKEENEKQAQeaqaEFTRKLAEKSVEVLRLSS 593
Cdd:PRK03918  164 YKNLGEVIKEIKRRI-----------ERLEKFIKRTENIEELIKEKEKELEEVLREIN----EISSELPELREELEKLEK 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   594 ELQNLKATSDSLESERVnktdECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDmLRLQKEGTEEKSTLLE 673
Cdd:PRK03918  229 EVKELEELKEEIEELEK----ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYE 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   674 KTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIE--QQLALKQNELEDFQKKQSE 751
Cdd:PRK03918  304 EYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHElyEEAKAKKEELERLKKRLTG 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   752 SEVHLQEIKAQNTQKDFELVEsgESLKKLQQQLEQKTLGHEKLQAALEELKK---------------EKETIIKEKEQEL 816
Cdd:PRK03918  384 LTPEKLEKELEELEKAKEEIE--EEISKITARIGELKKEIKELKKAIEELKKakgkcpvcgrelteeHRKELLEEYTAEL 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   817 QQLQSKSAESESALKVVQVQLEQLQQQAaasgeEGSKTVAKLHDEISQLKSQAEETQS------ELKSTQ-SNLEAKSKQ 889
Cdd:PRK03918  462 KRIEKELKEIEEKERKLRKELRELEKVL-----KKESELIKLKELAEQLKELEEKLKKynleelEKKAEEyEKLKEKLIK 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   890 LEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESK----TKQLEAANAALEKVNKEYAESRAEASDLQD 965
Cdd:PRK03918  537 LKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesVEELEERLKELEPFYNEYLELKDAEKELER 616

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   966 KVKEITDT----------LHAELQAERSSSSALHTKLSKFSDEiatGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ 1035
Cdd:PRK03918  617 EEKELKKLeeeldkafeeLAETEKRLEELRKELEELEKKYSEE---EYEELREEYLELSRELAGLRAELEELEKRREEIK 693

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 28574245  1036 DSQTKLKAEGERKEKSFEES---------IKNLQEEVTKAKTE 1069
Cdd:PRK03918  694 KTLEKLKEELEEREKAKKELeklekalerVEELREKVKKYKAL 736
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1278-1518 2.54e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.48  E-value: 2.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1278 QDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLdaqQATNKELQELLVKSQEN 1357
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQEL---AALEAELAELEKEIAEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1358 EGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSK 1437
Cdd:COG4942   96 RAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1438 LAEQLSQLKQANEELQKSLQQKQLLLekgNEFDTQLAEYQKVIDEMDDAAsvksallEQLQNRVAELETALRQANDAQKT 1517
Cdd:COG4942  176 LEALLAELEEERAALEALKAERQKLL---ARLEKELAELAAELAELQQEA-------EELEALIARLEAEAAAAAERTPA 245


                 .
gi 28574245 1518 A 1518
Cdd:COG4942  246 A 246
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 237-814 2.93e-11

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 68.56  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  237 MAVGDRVIVSSGFGsrpgILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV--------------- 301
Cdd:COG5244    4 LSVNDRVLLGDKFG----TVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIrpdddsllngnaaye 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  302 --------------PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTA---TSRMRMN------AQRKSSTPVKPI 358
Cdd:COG5244   80 kikgglvceskgmdKDGEIKQENHEDRIHFEESKIRRLEETIEALKSTEKEEiveLRRENEEldkinlSLRERISSEEPE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  359 LATPKSQFSMQDL--LREKQQHVEKLMVERDLDREDAQNQALQLQKNI--NELKARIVE--------LESALDNERKKTE 426
Cdd:COG5244  160 LNKDGSKLSYDELkeFVEESRVQVYDMVELVSDISETLNRNGSIQRSSvrECERSNIHDvlflvngiLDGVIDELNGELE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  427 ELQ---CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQkeV 503
Cdd:COG5244  240 RLRrqlVSLMSSHGIEVEENSRLKATLEKFQSLELKVNTL--QEELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEV--I 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  504 ESRIAEQLEeeqrlrenvkylNEQIATLQSELVSKDEALEKFSLSECgiENLRRELELLKEENEKQAQEAQAEFTRKLAE 583
Cdd:COG5244  316 ESENFGKLE------------NIEIHIILKVLSSISYALHIYTIKNT--PDHLETTLQCFVNIAPISMWLSEFLQRKFSS 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  584 KSVEVLrlsSELQNLKATSDSLE----------------------SERVNKTDECEILQTEVRMRdeQIRELNQQlDEVT 641
Cdd:COG5244  382 KQETAF---SICQFLEDNKDVTLilkilhpilettvpkllaflrtNSNFNDNDTLCLIGSLYEIA--RIDKLIGK-EEIS 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  642 TQLN----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 717
Cdd:COG5244  456 KQDNrlflYPSCDITLSSILTILFSDKLEVFFQGIESLLENITIFPEQPSQQTSDSENIKENSLLSDRLNEENIRLKEVL 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  718 ENAINQIQLEKESieQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE---KL 794
Cdd:COG5244  536 VQKENMLTEETKI--KIIIGRDLERKTLEENIKTLKVELNNKNNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKiylDL 613

                        650       660
                 ....*....|....*....|
gi 28574245  795 QAALEELKKEKETIIKEKEQ 814
Cdd:COG5244  614 VSEIMELRETIRRQIKEQKR 633
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1182-1457 3.66e-11

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 68.13  E-value: 3.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1182 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEK--LTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTK 1259
Cdd:pfam05667  215 ELAAAQEWEEEWNSQGLASRLTPEEYRKRKRTKLLKriAEQLRSAALAGTEATSGASRSAQDLAELLSSFSGSSTTDTGL 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1260 LNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDA 1339
Cdd:pfam05667  295 TKGSRFTHTEKLQFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEE 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1340 QQATNKELQE----------LLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQ-GKLDESNTVLE 1408
Cdd:pfam05667  375 LKEQNEELEKqykvkkktldLLPDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAKsNKEDESQRKLE 454

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245   1409 SQKKSHNEIQDKLEQAQQKE---RTLQEE-------------TSKLAEQLSQLKQANEELQKSLQ 1457
Cdd:pfam05667  455 EIKELREKIKEVAEEAKQKEelyKQLVAEyerlpkdvsrsayTRRILEIVKNIKKQKEEITKILS 519
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1208-1448 4.48e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 66.71  E-value: 4.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1208 QQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKK 1287
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1288 EKQLQEEAAKLSGELQQVQEANGDI----KDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLvksqenegnlqg 1363
Cdd:COG4942   99 LEAQKEELAELLRALYRLGRQPPLAlllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALR------------ 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1364 eslavteklQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLS 1443
Cdd:COG4942  167 ---------AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237


                 ....*
gi 28574245 1444 QLKQA 1448
Cdd:COG4942  238 AAAER 242
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 858-1482 4.52e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 67.74  E-value: 4.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    858 LHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTK 937
Cdd:TIGR04523   73 SNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEK 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    938 QLEAANAALEKVNKEYAESRAE----ASDLQDKVKEITDTLHAELQAERSSSS-----ALHTKLSKFSDEIATGHKELTS 1008
Cdd:TIGR04523  153 ELEKLNNKYNDLKKQKEELENElnllEKEKLNIQKNIDKIKNKLLKLELLLSNlkkkiQKNKSLESQISELKKQNNQLKD 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1009 KADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEES---IKNLQEEVTKAKTENLEL-STGTQTTIKDL 1084
Cdd:TIGR04523  233 NIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNnkkIKELEKQLNQLKSEISDLnNQKEQDWNKEL 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1085 QERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEvlqaeksETNHIFELFEMEADMNSER 1164
Cdd:TIGR04523  313 KSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELE-------EKQNEIEKLKKENQSYKQE 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1165 lIEKVTGIKEELKethLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEe 1244
Cdd:TIGR04523  386 -IKNLESQINDLE---SKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD- 460

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1245 kvressSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSgelQQVQEANGDIKDSLVKVEELVK 1324
Cdd:TIGR04523  461 ------NTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELE---EKVKDLTKKISSLKEKIEKLES 531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1325 VLEEKlqaatsqldAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:TIGR04523  532 EKKEK---------ESKISDLEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLI 602

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245   1405 tvlesqkkshNEIQDKLEQAQQKERtlqeetsklaeqlsQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE 1482
Cdd:TIGR04523  603 ----------KEIEEKEKKISSLEK--------------ELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKE 656
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 373-1271 5.50e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 67.76  E-value: 5.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    373 REKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQcSIDEAQFCGDELNAQsqvykek 452
Cdd:TIGR00606  216 KEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIK-ALKSRKKQMEKDNSE------- 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    453 ihdLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQ---EKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIA 529
Cdd:TIGR00606  288 ---LELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQrelEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIR 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    530 TLQSELVSKD-----EALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDs 604
Cdd:TIGR00606  365 ARDSLIQSLAtrlelDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIE- 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    605 LESERVNKTDE------CEILQTEVRMRDeqIRELNQQLDEVTTQLNvqKADSSALDDMLRLQKEGTEEKSTLLEKTEKE 678
Cdd:TIGR00606  444 LKKEILEKKQEelkfviKELQQLEGSSDR--ILELDQELRKAERELS--KAEKNSLTETLKKEVKSLQNEKADLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    679 LVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLE---KESIEQQLALKQNELEDFQKKQSESEVH 755
Cdd:TIGR00606  520 LDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYfpnKKQLEDWLHSKSKEINQTRDRLAKLNKE 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    756 LQEIKAQNTQKDFELVESGESLKKLQQQLEQkTLGHEKLQAALEELKKEketiIKEKEQELQQLQSKSAESESALKVVQV 835
Cdd:TIGR00606  600 LASLEQNKNHINNELESKEEQLSSYEDKLFD-VCGSQDEESDLERLKEE----IEKSSKQRAMLAGATAVYSQFITQLTD 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    836 QLEQLQQQAaasgEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLK 915
Cdd:TIGR00606  675 ENQSCCPVC----QRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELR 750

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    916 SEVGETQAALSSCHTDVESKTKQLEAANAAlEKVNKEYAESRAEASDLQDKVKEITDTLhaELQAERSSSSALHTKLSKF 995
Cdd:TIGR00606  751 NKLQKVNRDIQRLKNDIEEQETLLGTIMPE-EESAKVCLTDVTIMERFQMELKDVERKI--AQQAAKLQGSDLDRTVQQV 827

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    996 SDEIATGHKEL---TSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERK---EKSFEESIKNLQEEVTKAKTE 1069
Cdd:TIGR00606  828 NQEKQEKQHELdtvVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRqqfEEQLVELSTEVQSLIREIKDA 907

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1070 NLELSTGTQTTIKDLQERLEITNAELQHKEK-------MASEDAQKIADLKTLVEAIQVANAN-ISATNAELSTVLEVLQ 1141
Cdd:TIGR00606  908 KEQDSPLETFLEKDQQEKEELISSKETSNKKaqdkvndIKEKVKNIHGYMKDIENKIQDGKDDyLKQKETELNTVNAQLE 987

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1142 AEKSETNHIfelfemEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLK------------QAQQSEQKLQQ 1209
Cdd:TIGR00606  988 ECEKHQEKI------NEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKqhlkemgqmqvlQMKQEHQKLEE 1061

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245   1210 ESQTSKEKLTEIQQSLQELQDSVKQ-----KEELVQNLEEKVREssSIIEAQNTKLNESNVQLENKT 1271
Cdd:TIGR00606 1062 NIDLIKRNHVLALGRQKGYEKEIKHfkkelREPQFRDAEEKYRE--MMIVMRTTELVNKDLDIYYKT 1126
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 719-1456 6.91e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 67.35  E-value: 6.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    719 NAINQIQLEKESIEQQLALKQNELEDFQKKqsesevhlqeikaqntqkdfelvesgesLKKLQQQLEQKtlgheklqaal 798
Cdd:TIGR04523   26 NIANKQDTEEKQLEKKLKTIKNELKNKEKE----------------------------LKNLDKNLNKD----------- 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    799 EELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSktvaKLHDEISQLKSQAEETQSELKS 878
Cdd:TIGR04523   67 EEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN----KLEVELNKLEKQKKENKKNIDK 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    879 TQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALsschTDVESKTKQLEAANAALEKVNKEYAESRA 958
Cdd:TIGR04523  143 FLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNI----DKIKNKLLKLELLLSNLKKKIQKNKSLES 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    959 EASDLQDKVKEITDTlhaeLQAERSSSSALHTKLSKFSDEIatghKELTSKADAWSQEMLQKEKELQelrqqlqdsqdsq 1038
Cdd:TIGR04523  219 QISELKKQNNQLKDN----IEKKQQEINEKTTEISNTQTQL----NQLKDEQNKIKKQLSEKQKELE------------- 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1039 tklkaEGERKEKSFEESIKNLQEEVTKAKTE-NLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVE 1117
Cdd:TIGR04523  278 -----QNNKKIKELEKQLNQLKSEISDLNNQkEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1118 AIQVANANISATNAELSTVLEVLQAEKSETNhifelfemeadmnserliEKVTGIKEELKETHLQLDERQKKFEELEEKL 1197
Cdd:TIGR04523  353 NSESENSEKQRELEEKQNEIEKLKKENQSYK------------------QEIKNLESQINDLESKIQNQEKLNQQKDEQI 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1198 KQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEekvressSIIEAQNTKLNESNVQLENKTSCLKET 1277
Cdd:TIGR04523  415 KKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD-------NTRESLETQLKVLSRSINKIKQNLEQK 487

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1278 QDQLLESQKKEKQLQEEAAKLSgelQQVQEANGDIKDSLVKVEELVKVLEEKlqaatsqldAQQATNKELQELLVKSQEN 1357
Cdd:TIGR04523  488 QKELKSKEKELKKLNEEKKELE---EKVKDLTKKISSLKEKIEKLESEKKEK---------ESKISDLEDELNKDDFELK 555

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1358 EGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSK 1437
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKN 635

                          730
                   ....*....|....*....
gi 28574245   1438 LAEQLSQLKQANEELQKSL 1456
Cdd:TIGR04523  636 IKSKKNKLKQEVKQIKETI 654
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1371-1599 9.23e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.88  E-value: 9.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1371 KLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLS----QLK 1446
Cdd:COG1196  233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIArleeRRR 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1447 QANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELR 1526
Cdd:COG1196  313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1527 RQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETL 1599
Cdd:COG1196  393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
381-1001 1.10e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.60  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   381 KLMVERDLDreDAQNQALQLQKNINE-----LKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHD 455
Cdd:PRK02224  175 RLGVERVLS--DQRGSLDQLKAQIEEkeekdLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   456 LESkitklvsatpslqsilppdlpsddgaLQEEIAKLQEKmtiqqkevesrIAEQLEEEQRLRENVKYLNEQIATLQSEL 535
Cdd:PRK02224  253 LET--------------------------LEAEIEDLRET-----------IAETEREREELAEEVRDLRERLEELEEER 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   536 vskDEALEKFSLSECGIEnlrrelelLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDE 615
Cdd:PRK02224  296 ---DDLLAEAGLDDADAE--------AVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREE 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   616 CEILQTE-------VRMRDEQIRELNQQLDEVTTQLN---VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQ 685
Cdd:PRK02224  365 AAELESEleeareaVEDRREEIEELEEEIEELRERFGdapVDLGNAEDFLEELREERDELREREAELEATLRTARERVEE 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   686 AAKTLNdkeqlEKQISDLKQLAEQEKLVREMTENainqiqlekesiEQQLALKQNELEDFQKKQSESEvhlqeikaqntq 765
Cdd:PRK02224  445 AEALLE-----AGKCPECGQPVEGSPHVETIEED------------RERVEELEAELEDLEEEVEEVE------------ 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   766 kdfELVESGESLKKLQQQLEQKtlghEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvQVQLEQLQQQAA 845
Cdd:PRK02224  496 ---ERLERAEDLVEAEDRIERL----EERREDLEELIAERRETIEEKRERAEELRERAAELEAE----AEEKREAAAEAE 564

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   846 ASGEEGSKTVAKLHDEISQLKSQAE------ETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVG 919
Cdd:PRK02224  565 EEAEEAREEVAELNSKLAELKERIEslerirTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFD 644

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   920 ETQaalsschtdVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLH--AELQAERSSSSALHTKLSKFSD 997
Cdd:PRK02224  645 EAR---------IEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEelEELRERREALENRVEALEALYD 715


                  ....
gi 28574245   998 EIAT 1001
Cdd:PRK02224  716 EAEE 719
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1174-1386 1.12e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.56  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1174 EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1253
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1254 EAQNTKLNESNVQLEnKTSclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAA 1333
Cdd:COG4942  100 EAQKEELAELLRALY-RLG--RQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAEL 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1334 TSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEAL 1386
Cdd:COG4942  177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1153-1464 1.14e-10

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 66.40  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1153 LFEMEADMNSERLIEkvtgIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSV 1232
Cdd:PRK04778   88 LFEAEELNDKFRFRK----AKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1233 --------KQKEELVQNLEEKVRESSS--IIEAQNT--KLNESNVQLENKT--------SCLKETQDQLLESQKKEKQLQ 1292
Cdd:PRK04778  164 gpaldeleKQLENLEEEFSQFVELTESgdYVEAREIldQLEEELAALEQIMeeipellkELQTELPDQLQELKAGYRELV 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1293 EE-----AAKLSGELQQVQEAngdIKDSLVKVEEL-VKVLEEKLQAATSQLD-----------AQQ---ATNKELQELLV 1352
Cdd:PRK04778  244 EEgyhldHLDIEKEIQDLKEQ---IDENLALLEELdLDEAEEKNEEIQERIDqlydilerevkARKyveKNSDTLPDFLE 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1353 KSQENEGNLQGEslavTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQ 1432
Cdd:PRK04778  321 HAKEQNKELKEE----IDRVKQSYTLNESELESVRQLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIE 396

                         330       340       350
                  ....*....|....*....|....*....|..
gi 28574245  1433 EETSKLAEQLSQLKQANEELQKSLQQKQLLLE 1464
Cdd:PRK04778  397 KEQEKLSEMLQGLRKDELEAREKLERYRNKLH 428
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1165-1533 1.17e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 66.63  E-value: 1.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1165 LIEKVTGIKE--ELKETHL-QLDERQKKFEELEEKLKQAQQSEQKLQQESQTsKEKLTEIQQSLQELQDSVKQKEElvqn 1241
Cdd:TIGR02169  158 IIDEIAGVAEfdRKKEKALeELEEVEENIERLDLIIDEKRQQLERLRREREK-AERYQALLKEKREYEGYELLKEK---- 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1242 leEKVRESSSIIEAQNTKLNESNVQLEnktsclKETQDQLLESQKKEKQLQEEAAKL----SGELQQVQEANGDIKDSLV 1317
Cdd:TIGR02169  233 --EALERQKEAIERQLASLEEELEKLT------EEISELEKRLEEIEQLLEELNKKIkdlgEEEQLRVKEKIGELEAEIA 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1318 KVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQ 1397
Cdd:TIGR02169  305 SLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1398 GKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGnefDTQLAEYQ 1477
Cdd:TIGR02169  385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ---EWKLEQLA 461

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   1478 KVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1533
Cdd:TIGR02169  462 ADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLK 517
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 383-804 1.60e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 66.23  E-value: 1.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    383 MVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITK 462
Cdd:TIGR02168  672 ILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    463 lvsatpslqsilppdlpsddgaLQEEIAKLQEKMTiqqkEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL 542
Cdd:TIGR02168  752 ----------------------LSKELTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    543 EKFS--LSECGIENLRRELELLKEENEKQAQEAQAEFTRK-LAEKSVEVLRLSSELQNLKATSDSLESERvnktdecEIL 619
Cdd:TIGR02168  806 DELRaeLTLLNEEAANLRERLESLERRIAATERRLEDLEEqIEELSEDIESLAAEIEELEELIEELESEL-------EAL 878

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    620 QTEVRMRDEQIRELNQQLDEVTTQLNvqkadsSALDDMLRLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQLekq 699
Cdd:TIGR02168  879 LNERASLEEALALLRSELEELSEELR------ELESKRSELRRE--------LEELREKLAQLELRLEGLEVRIDNL--- 941

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    700 isdLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFqkkqseSEVHL---QEIKAQNTQKDFelvesges 776
Cdd:TIGR02168  942 ---QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL------GPVNLaaiEEYEELKERYDF-------- 1004

                          410       420
                   ....*....|....*....|....*...
gi 28574245    777 lkkLQQQLEQKTLGHEKLQAALEELKKE 804
Cdd:TIGR02168 1005 ---LTAQKEDLTEAKETLEEAIEEIDRE 1029
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
961-1599 1.70e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.22  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   961 SDLQDKVKEITDT-LHAELQAERSSSSALHTKLSKFSDEIATGhKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSqt 1039
Cdd:PRK02224  190 DQLKAQIEEKEEKdLHERLNGLESELAELDEEIERYEEQREQA-RETRDEADEVLEEHEERREELETLEAEIEDLRET-- 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1040 klKAEGERKEKSFEESIKNLQEEVTKAKTEN------LELSTGTQTTIKDLQERLEITNAELQhkekmasedaqkiadlk 1113
Cdd:PRK02224  267 --IAETEREREELAEEVRDLRERLEELEEERddllaeAGLDDADAEAVEARREELEDRDEELR----------------- 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1114 tlvEAIQVANANISATNAELSTVLEvlQAEKSETNhifelfemeadmnSERLIEKVTGIKEELKETHLQLDERQKKFEEL 1193
Cdd:PRK02224  328 ---DRLEECRVAAQAHNEEAESLRE--DADDLEER-------------AEELREEAAELESELEEAREAVEDRREEIEEL 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1194 EEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSC 1273
Cdd:PRK02224  390 EEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGQPVEGSPHVET 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1274 LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEangdikdsLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVK 1353
Cdd:PRK02224  470 IEEDRERVEELEAELEDLEEEVEEVEERLERAED--------LVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1354 SQENEGNLQGESLAVTEKLQQLEQANGELKEALcqkenglKELQGKLDESNTVLESQkkshNEIQDKLEQAQQKERTLQE 1433
Cdd:PRK02224  542 LRERAAELEAEAEEKREAAAEAEEEAEEAREEV-------AELNSKLAELKERIESL----ERIRTLLAAIADAEDEIER 610

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1434 etskLAEQLSQLKQANEELQKSLQQKqlllekgNEFDTQLAEyqkvidEMDDAAsvksalLEQLQNRVAELETALRQAND 1513
Cdd:PRK02224  611 ----LREKREALAELNDERRERLAEK-------RERKRELEA------EFDEAR------IEEAREDKERAEEYLEQVEE 667

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1514 aqktaylETKELRRQLESLEleksrevlslkAQMNGASSrsgkgdEVESLDietslakinflnsiiaDMQQKNDALKAKV 1593
Cdd:PRK02224  668 -------KLDELREERDDLQ-----------AEIGAVEN------ELEELE----------------ELRERREALENRV 707


                  ....*.
gi 28574245  1594 QTLETL 1599
Cdd:PRK02224  708 EALEAL 713
PTZ00121 PTZ00121
MAEBL; Provisional
 421-1023 2.32e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.93  E-value: 2.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   421 ERKKTEELQCSIDEAQfCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSilPPDLPSDDGALQEEIAKLQEKMTIQQ 500
Cdd:PTZ00121 1300 EKKKADEAKKKAEEAK-KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA--EAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   501 KEvESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIEnlrreLELLKEENEKQAQEA-QAEFTR 579
Cdd:PTZ00121 1377 KK-KADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAE-----EKKKADEAKKKAEEAkKADEAK 1450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   580 KLAE--KSVEVLRLSSElQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIR---ELNQQLDEVTTQLNVQKADSSAL 654
Cdd:PTZ00121 1451 KKAEeaKKAEEAKKKAE-EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKkaaEAKKKADEAKKAEEAKKADEAKK 1529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   655 DDMLRLQKEG--TEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIE 732
Cdd:PTZ00121 1530 AEEAKKADEAkkAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   733 QQLalKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQqqlEQKTLGHEKLQAALEELKKEKETIIKEK 812
Cdd:PTZ00121 1610 EEA--KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE---EENKIKAAEEAKKAEEDKKKAEEAKKAE 1684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   813 EQELQQLQSKSAESESALKVVQVQLEQLQQQAAasGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKqleA 892
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK--AEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKK---I 1759

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   893 ANGSLEEEAKKSGHLLEQITKLKSEVGETQaalSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQD-KVKEIT 971
Cdd:PTZ00121 1760 AHLKKEEEKKAEEIRKEKEAVIEEELDEED---EKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDsAIKEVA 1836

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 28574245   972 DTlhAELQAERSSSSALHtKLSKFSDEIATGHKELTSKADAWSQEMLQKEKE 1023
Cdd:PTZ00121 1837 DS--KNMQLEEADAFEKH-KFNKNNENGEDGNKEADFNKEKDLKEDDEEEIE 1885
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1187-1526 2.33e-10

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 65.24  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1187 QKKFEELEE-----KLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLN 1261
Cdd:PRK04778   85 EEQLFEAEElndkfRFRKAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSFG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1262 ESNVQLENKtscLKETQDQLlesqKKEKQLQEEA--AKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAatsQLDA 1339
Cdd:PRK04778  165 PALDELEKQ---LENLEEEF----SQFVELTESGdyVEAREILDQLEEELAALEQIMEEIPELLKELQTELPD---QLQE 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1340 QQATNKELQEllvksqEN----EGNLQGESLAVTEKLQQLEQ--ANGELKEAlcqkENGLKELQGKLDESNTVLESQKKS 1413
Cdd:PRK04778  235 LKAGYRELVE------EGyhldHLDIEKEIQDLKEQIDENLAllEELDLDEA----EEKNEEIQERIDQLYDILEREVKA 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1414 HNEIQDKLEqaqqkerTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSAL 1493
Cdd:PRK04778  305 RKYVEKNSD-------TLPDFLEHAKEQNKELKEEIDRVKQSYTLNESELESVRQLEKQLESLEKQYDEITERIAEQEIA 377

                         330       340       350
                  ....*....|....*....|....*....|...
gi 28574245  1494 LEQLQNRVAELETALRQANDAQKTAYLETKELR 1526
Cdd:PRK04778  378 YSELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1211-1454 5.09e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 63.24  E-value: 5.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1211 SQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLenktsclKETQDQLLESQKKEKQ 1290
Cdd:COG4942   15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI-------RALEQELAALEAELAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1291 LQEEAAKLSGELQQVQEANGDIKDSLVKVEElvkvlEEKLQAATSQLDAQQA-TNKELQELLVKSQENEGNlqgeslAVT 1369
Cdd:COG4942   88 LEKEIAELRAELEAQKEELAELLRALYRLGR-----QPPLALLLSPEDFLDAvRRLQYLKYLAPARREQAE------ELR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1370 EKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAN 1449
Cdd:COG4942  157 ADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236


                 ....*
gi 28574245 1450 EELQK 1454
Cdd:COG4942  237 AAAAE 241
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1012-1590 5.16e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.61  E-value: 5.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1012 AWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEIT 1091
Cdd:pfam02463  163 AGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1092 NAEL---QHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEK 1168
Cdd:pfam02463  243 QELLrdeQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1169 VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRE 1248
Cdd:pfam02463  323 KKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSE 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1249 SSSIIEAQNTKLNESNVQLEN-------KTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1321
Cdd:pfam02463  403 EEKEAQLLLELARQLEDLLKEekkeeleILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKL 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1322 LVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELK-EALCQKENGLKELQGKL 1400
Cdd:pfam02463  483 QEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAiSTAVIVEVSATADEVEE 562

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1401 DESNT-VLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAneelqKSLQQKQLLLEKGNEFDTQLAEYQKV 1479
Cdd:pfam02463  563 RQKLVrALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKA-----TLEADEDDKRAKVVEGILKDTELTKL 637

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1480 IDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVL--SLKAQMNGASSRSGKG 1557
Cdd:pfam02463  638 KESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLeiKKKEQREKEELKKLKL 717

                          570       580       590
                   ....*....|....*....|....*....|...
gi 28574245   1558 DEVESLDIETSLAKINFLNSIIADMQQKNDALK 1590
Cdd:pfam02463  718 EAEELLADRVQEAQDKINEELKLLKQKIDEEEE 750
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 400-718 6.41e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 64.32  E-value: 6.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    400 LQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPpDLP 479
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELK-ELE 764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    480 SDDGALQEEIAKLQEKM-TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELvsKDEALEKFSLSEcgienlrre 558
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALnDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL--NRLTLEKEYLEK--------- 833

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    559 LELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLD 638
Cdd:TIGR02169  834 EIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIE 913

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    639 EVTTQLNVQKADSSALDDML----RLQKEGTEEKS-TLLEKTEKELVQSKEQAAKTL--------NDKEQLEKQISDLKq 705
Cdd:TIGR02169  914 KKRKRLSELKAKLEALEEELseieDPKGEDEEIPEeELSLEDVQAELQRVEEEIRALepvnmlaiQEYEEVLKRLDELK- 992

                          330
                   ....*....|...
gi 28574245    706 lAEQEKLVREMTE 718
Cdd:TIGR02169  993 -EKRAKLEEERKA 1004
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1174-1510 8.42e-10

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 63.55  E-value: 8.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1174 EELKETHLQL----DERQKKFEELEEKLKQAQQSEQKLQ---QESQTSKEKLTEIQQS------LQELQDSVKQKEELVQ 1240
Cdd:pfam05622   69 EQLQEENFRLetarDDYRIKCEELEKEVLELQHRNEELTslaEEAQALKDEMDILRESsdkvkkLEATVETYKKKLEDLG 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1241 NLEEKVR--ESSSIIEAQNT--------KLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEAng 1310
Cdd:pfam05622  149 DLRRQVKllEERNAEYMQRTlqleeelkKANALRGQLETYKRQVQELHGKLSEESKKADKLEFEYKKLEEKLEALQKE-- 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1311 diKDSLVKVEELVKVLEEKLQAAtsqlDAQQATNKELQELLVKSQENEGNLQGE--SLAVTEKLQQLEQANGELKealCQ 1388
Cdd:pfam05622  227 --KERLIIERDTLRETNEELRCA----QLQQAELSQADALLSPSSDPGDNLAAEimPAEIREKLIRLQHENKMLR---LG 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1389 KEnglkelqgkldesntvlESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1468
Cdd:pfam05622  298 QE-----------------GSYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSL 360

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 28574245   1469 FDTQLAEYQKVIDEMDDAASVKSALLEQLQN--------RVAELETALRQ 1510
Cdd:pfam05622  361 LKQKLEEHLEKLHEAQSELQKKKEQIEELEPkqdsnlaqKIDELQEALRK 410
mukB PRK04863
chromosome partition protein MukB;
667-1533 1.10e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 63.82  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   667 EKSTLLEKTEKELVQSKEQAAKTLN-------DKEQLEKQISDLK----QLAEQEKLV------REMTENAINQIQLEKE 729
Cdd:PRK04863  314 RELAELNEAESDLEQDYQAASDHLNlvqtalrQQEKIERYQADLEeleeRLEEQNEVVeeadeqQEENEARAEAAEEEVD 393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   730 SIEQQLALKQNELEDFQKKQSESEvhlQEIKAqntqkdfelvesgesLKKLQQQLEQKTLGHEKLQAALEELKKEKetii 809
Cdd:PRK04863  394 ELKSQLADYQQALDVQQTRAIQYQ---QAVQA---------------LERAKQLCGLPDLTADNAEDWLEEFQAKE---- 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   810 KEKEQELQQLQSKSAESESALKVVqvqleqlqqqaaasgEEGSKTVAKLHDEISqlKSQAEETQSELKSTQSNLEAKSKQ 889
Cdd:PRK04863  452 QEATEELLSLEQKLSVAQAAHSQF---------------EQAYQLVRKIAGEVS--RSEAWDVARELLRRLREQRHLAEQ 514

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   890 LEAANGSLEEeAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAAnaaLEKVNKEYAESRAEASDLQDKVKE 969
Cdd:PRK04863  515 LQQLRMRLSE-LEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEAR---LESLSESVSEARERRMALRQQLEQ 590

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   970 ItDTLHAELQAERSSSSALHTKLSKFSDEiaTGHKELTSKA-DAWSQEMLQKEKELQELRQqlqdsqdsqtklkaEGERK 1048
Cdd:PRK04863  591 L-QARIQRLAARAPAWLAAQDALARLREQ--SGEEFEDSQDvTEYMQQLLERERELTVERD--------------ELAAR 653

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1049 EKSFEESIKNLQEEvtkaktenlelSTGTQTTIKDLQERLE-ITNAELQhkEKMASEDAQKI-ADLKTLVEAIQVAnani 1126
Cdd:PRK04863  654 KQALDEEIERLSQP-----------GGSEDPRLNALAERFGgVLLSEIY--DDVSLEDAPYFsALYGPARHAIVVP---- 716

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1127 satnaELSTVLEVLQAEKSETNhifELFEMEADMNSerLIEKVTGIKEELKETHLQLDERQ---KKFEEL--------EE 1195
Cdd:PRK04863  717 -----DLSDAAEQLAGLEDCPE---DLYLIEGDPDS--FDDSVFSVEELEKAVVVKIADRQwrySRFPEVplfgraarEK 786

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1196 KLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQK---------EELVQNLEEKVREsssiIEAQNTKLNESNVQ 1266
Cdd:PRK04863  787 RIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFIGSHlavafeadpEAELRQLNRRRVE----LERALADHESQEQQ 862

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1267 LENKTSCLKETQDQL--LESQKK---EKQLQEEAAKLSGELQQVQEANGDIKdslvkveelvkvleeKLQAATSQLDAQQ 1341
Cdd:PRK04863  863 QRSQLEQAKEGLSALnrLLPRLNllaDETLADRVEEIREQLDEAEEAKRFVQ---------------QHGNALAQLEPIV 927

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1342 ATnkeLQEllvkSQENEGNLQGESLAVTEKLQQLEQANGELKEaLCQKENGLK--ELQGKLDESNTVLESqkkshneIQD 1419
Cdd:PRK04863  928 SV---LQS----DPEQFEQLKQDYQQAQQTQRDAKQQAFALTE-VVQRRAHFSyeDAAEMLAKNSDLNEK-------LRQ 992

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1420 KLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQlllekgnefdTQLAEYQKVIDEMDDAASvkSALLEQLQN 1499
Cdd:PRK04863  993 RLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKR----------QMLQELKQELQDLGVPAD--SGAEERARA 1060

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|..
gi 28574245  1500 RVAELETALRqANDAQKTAY--------LETKELRRQLESLE 1533
Cdd:PRK04863 1061 RRDELHARLS-ANRSRRNQLekqltfceAEMDNLTKKLRKLE 1101
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 582-1254 1.17e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 63.45  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    582 AEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQ 661
Cdd:TIGR00618  194 GKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    662 K-----EGTEEKSTLLEKTEK---------ELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLE 727
Cdd:TIGR00618  274 AqeavlEETQERINRARKAAPlaahikavtQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQ 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    728 KESIEQQLALKQNELEDFQKKQSESE--VHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEK 805
Cdd:TIGR00618  354 EIHIRDAHEVATSIREISCQQHTLTQhiHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQ 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    806 ETIIKEKEQELQ--QLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNL 883
Cdd:TIGR00618  434 ELQQRYAELCAAaiTCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHP 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    884 EAKSKQLeaanGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDL 963
Cdd:TIGR00618  514 NPARQDI----DNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNL 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    964 QDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELT--SKADAWSQEMLQKEKELQELRQQLQDSQDSQTK- 1040
Cdd:TIGR00618  590 QNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHlqQCSQELALKLTALHALQLTLTQERVREHALSIRv 669

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1041 LKAEGERKEKSFEESIKNLQEEVTKAKTE----NLELSTGTQTTIKDLQERLEITNAELQHKEKMASED---AQKIADLK 1113
Cdd:TIGR00618  670 LPKELLASRQLALQKMQSEKEQLTYWKEMlaqcQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREdalNQSLKELM 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1114 TLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEEL 1193
Cdd:TIGR00618  750 HQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQE 829

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245   1194 EEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIE 1254
Cdd:TIGR00618  830 EEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDG 890
PTZ00121 PTZ00121
MAEBL; Provisional
 1048-1540 1.32e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1048 KEKSFEESIKNLQEEVTKAKTENLELSTGTQTTikdlqerlEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANIS 1127
Cdd:PTZ00121 1077 KDFDFDAKEDNRADEATEEAFGKAEEAKKTETG--------KAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKA 1148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1128 ATNAELSTVLEVLQAEKSEtnhIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEElEEKLKQAQQSEQKL 1207
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAE---EARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEE-ERKAEEARKAEDAK 1224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1208 QQESQtskEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKK 1287
Cdd:PTZ00121 1225 KAEAV---KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK 1301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1288 EKQlqEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGE--- 1364
Cdd:PTZ00121 1302 KKA--DEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAkkk 1379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1365 SLAVTEKLQQLEQANgELKEALCQKENGLKELQGKLDESNTVLESQKKShnEIQDKLEQAQQK--ERTLQEETSKLAEQ- 1441
Cdd:PTZ00121 1380 ADAAKKKAEEKKKAD-EAKKKAEEDKKKADELKKAAAAKKKADEAKKKA--EEKKKADEAKKKaeEAKKADEAKKKAEEa 1456

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1442 --LSQLKQANEELQKSLQQKQLLLE--KGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKT 1517
Cdd:PTZ00121 1457 kkAEEAKKKAEEAKKADEAKKKAEEakKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536

                         490       500
                  ....*....|....*....|...
gi 28574245  1518 AYLETKELRRQLEslELEKSREV 1540
Cdd:PTZ00121 1537 DEAKKAEEKKKAD--ELKKAEEL 1557
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1163-1598 1.33e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1163 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQS--------EQKLQQESQTSKEKLTEIQQSLQELQdsvkq 1234
Cdd:COG4913  291 ELLEAELEELRAELARLEAELERLEARLDALREELDELEAQirgnggdrLEQLEREIERLERELEERERRRARLE----- 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1235 keELVQNLEEKVRESSSIIEAQNTKLNEsnvQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQ---------- 1304
Cdd:COG4913  366 --ALLAALGLPLPASAEEFAALRAEAAA---LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASlerrksnipa 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1305 -VQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKEL----QELLVKSQ------------ENEGNLQGESLA 1367
Cdd:COG4913  441 rLLALRDALAEALGLDEAELPFVGELIEVRPEEERWRGAIERVLggfaLTLLVPPEhyaaalrwvnrlHLRGRLVYERVR 520

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1368 VTEKLQQLEQAN-GELKEALCQKENGLKE-LQGKLDESNTV--------------------LESQKKSHNEIQD------ 1419
Cdd:COG4913  521 TGLPDPERPRLDpDSLAGKLDFKPHPFRAwLEAELGRRFDYvcvdspeelrrhpraitragQVKGNGTRHEKDDrrrirs 600

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1420 ----------KLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEF------DTQLAEYQKVIDEM 1483
Cdd:COG4913  601 ryvlgfdnraKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEidvasaEREIAELEAELERL 680

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1484 DDAasvkSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLEleksREVLSLKAQMNGASSRsgkGDEVESL 1563
Cdd:COG4913  681 DAS----SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAE----EELDELQDRLEAAEDL---ARLELRA 749

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 28574245 1564 DIETSLAKI---NFLNSIIADMQQKNDALKAKVQTLET 1598
Cdd:COG4913  750 LLEERFAAAlgdAVERELRENLEERIDALRARLNRAEE 787
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 694-1594 1.37e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.21  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    694 EQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEiKAQNTQKDFELVES 773
Cdd:pfam15921   81 EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRN-QLQNTVHELEAAKC 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    774 geslkklqqqLEQKTLGHEKLQaaLEELKKeketIIKEKEQELQQLQSKSAESESAL-KVVQVQLEQLQQQAAASGEEGS 852
Cdd:pfam15921  160 ----------LKEDMLEDSNTQ--IEQLRK----MMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLGSAIS 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    853 KTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLeaangsLEEEAKKSGHLleqITKLKSEVGETQAALSSCHTDV 932
Cdd:pfam15921  224 KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELL------LQQHQDRIEQL---ISEHEVEITGLTEKASSARSQA 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    933 ESKTKQLEAANAALEKVNKEYAEsraEASDLQDKVKEITDTLhaelqaeRSSSSALHTKLSKFSDEIATGHKELT---SK 1009
Cdd:pfam15921  295 NSIQSQLEIIQEQARNQNSMYMR---QLSDLESTVSQLRSEL-------REAKRMYEDKIEELEKQLVLANSELTearTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1010 ADAWSQEMLQKEKELQelrqqlqdsqdsqtKLKAEGERKEKsfeesiknlqeEVTKAKTENLEL---STGTQTTIKDLQE 1086
Cdd:pfam15921  365 RDQFSQESGNLDDQLQ--------------KLLADLHKREK-----------ELSLEKEQNKRLwdrDTGNSITIDHLRR 419

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1087 RLEITNAELQHKEKMasedaqkiadlktlveaiqvananisatnaelstvlevLQAEKSETNHIFELfEMEADMNSERLI 1166
Cdd:pfam15921  420 ELDDRNMEVQRLEAL--------------------------------------LKAMKSECQGQMER-QMAAIQGKNESL 460

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1167 EKVTGIKEELKETHLQLderQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKV 1246
Cdd:pfam15921  461 EKVSSLTAQLESTKEML---RKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1247 RESSSIIEAQnTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEangDIKDSLVKVEELvKVL 1326
Cdd:pfam15921  538 NEGDHLRNVQ-TECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEK---EINDRRLELQEF-KIL 612

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1327 EEKLQAATSQLDAqqatnkelqellvksqenegnlqgeslavteKLQQLEQANGELKEALCQKENGLKELQgklDESNTV 1406
Cdd:pfam15921  613 KDKKDAKIRELEA-------------------------------RVSDLELEKVKLVNAGSERLRAVKDIK---QERDQL 658

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1407 LESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDtqlAEYQKVIDEMDDA 1486
Cdd:pfam15921  659 LNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSD---GHAMKVAMGMQKQ 735

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1487 ASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMngaSSRSGKGDEVESLDIE 1566
Cdd:pfam15921  736 ITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLR---SQERRLKEKVANMEVA 812

                          890       900
                   ....*....|....*....|....*...
gi 28574245   1567 TSLAKINFLNSIIADMQQKNDALKAKVQ 1594
Cdd:pfam15921  813 LDKASLQFAECQDIIQRQEQESVRLKLQ 840
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 680-1478 1.75e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 63.14  E-value: 1.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    680 VQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEI 759
Cdd:TIGR00606  185 IKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKI 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    760 -KAQNTQKDFELVEsgESLKKLQQQLEQKTLG-HEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESalKVVQVQL 837
Cdd:TIGR00606  265 mKLDNEIKALKSRK--KQMEKDNSELELKMEKvFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNK--ERRLLNQ 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    838 EQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSK-------QLEAANGSLEEEAKKSGHLLEQ 910
Cdd:TIGR00606  341 EKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQiknfhtlVIERQEDEAKTAAQLCADLQSK 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    911 ITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHT 990
Cdd:TIGR00606  421 ERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLK 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    991 KLSKFsdeIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEN 1070
Cdd:TIGR00606  501 KEVKS---LQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1071 LELSTGTQttIKDLQERLEITNAELQHKEKMA----SEDAQKIADLKTLVEAI------QVANANISATNAELSTVLEVL 1140
Cdd:TIGR00606  578 WLHSKSKE--INQTRDRLAKLNKELASLEQNKnhinNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQR 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1141 QAEKSETNHIFELFEMEADMNSE--RLIEKVTGIKEELKETHLQLderQKKFEELEEKLKQAQQSEQKLQQESQTSKEKL 1218
Cdd:TIGR00606  656 AMLAGATAVYSQFITQLTDENQSccPVCQRVFQTEAELQEFISDL---QSKLRLAPDKLKSTESELKKKEKRRDEMLGLA 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1219 TEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKET---QDQLLESQKKEKQLQEEA 1295
Cdd:TIGR00606  733 PGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVtimERFQMELKDVERKIAQQA 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1296 AKLSGElqqvqeangDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQL 1375
Cdd:TIGR00606  813 AKLQGS---------DLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRR 883

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1376 EQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS 1455
Cdd:TIGR00606  884 QQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENK 963

                          810       820
                   ....*....|....*....|....*...
gi 28574245   1456 LQQ--KQLLLEKGNEFDT---QLAEYQK 1478
Cdd:TIGR00606  964 IQDgkDDYLKQKETELNTvnaQLEECEK 991
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
388-992 2.15e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 62.63  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  388 LDREDAQNQALQLQKNINELKarivELESALDNERKKTEELQcsideaqfcgdELNAQSQVYKEKIHDLEsKITKLVSAT 467
Cdd:COG4913  218 LEEPDTFEAADALVEHFDDLE----RAHEALEDAREQIELLE-----------PIRELAERYAAARERLA-ELEYLRAAL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  468 PSLQSILppdlpsDDGALQEEIAKLQE---KMTIQQKEVESRIAEQLEEEQRLRENVKYL-NEQIATLQSELVSKDEALE 543
Cdd:COG4913  282 RLWFAQR------RLELLEAELEELRAelaRLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELE 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  544 KfslsecgienlrreleLLKEENEKQAQEAQAEFTRKLAEKSVEVLRlsselQNLKATSDSLESERvnktdecEILQTEV 623
Cdd:COG4913  356 E----------------RERRRARLEALLAALGLPLPASAEEFAALR-----AEAAALLEALEEEL-------EALEEAL 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  624 RMRDEQIRELNQQLDEVTTQLNVQKADSSALD-DMLRLQKEGTEEkstlLEKTEK------ELVQSKEQAAKTLNDKEQL 696
Cdd:COG4913  408 AEAEAALRDLRRELRELEAEIASLERRKSNIPaRLLALRDALAEA----LGLDEAelpfvgELIEVRPEEERWRGAIERV 483

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  697 -----------EKQISDLKQLAEQEKL--------VREMTENAINQiQLEKESIEQQLALKQNELEDFqkkqsesevhLQ 757
Cdd:COG4913  484 lggfaltllvpPEHYAAALRWVNRLHLrgrlvyerVRTGLPDPERP-RLDPDSLAGKLDFKPHPFRAW----------LE 552

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  758 EIKAQntQKDFELVESGESLKKLQQ------QLEQKTLGHEK---------------LQAALEELKKEketiIKEKEQEL 816
Cdd:COG4913  553 AELGR--RFDYVCVDSPEELRRHPRaitragQVKGNGTRHEKddrrrirsryvlgfdNRAKLAALEAE----LAELEEEL 626

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  817 QQLQSKSAESESALKVVQVQLEQLQQQAAASGEEgsKTVAKLHDEISQLksqaEETQSELKSTQSNLEAKSKQLEAANGS 896
Cdd:COG4913  627 AEAEERLEALEAELDALQERREALQRLAEYSWDE--IDVASAEREIAEL----EAELERLDASSDDLAALEEQLEELEAE 700

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  897 LEEeakksghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA 976
Cdd:COG4913  701 LEE-------LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEE 773

                        650
                 ....*....|....*.
gi 28574245  977 ELQAERSSSSALHTKL 992
Cdd:COG4913  774 RIDALRARLNRAEEEL 789
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1091-1592 3.15e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.05  E-value: 3.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1091 TNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERlIEKVT 1170
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEK-TKKYE 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1171 GIKEELKETHLQLDER-QKKFEELEEKLKQAQQSEQKLQQESQTSKEKlteIQQSLQELQDSVKQKEELVQNL------- 1242
Cdd:pfam05483  176 YEREETRQVYMDLNNNiEKMILAFEELRVQAENARLEMHFKLKEDHEK---IQHLEEEYKKEINDKEKQVSLLliqitek 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1243 EEKVRESSSIIEAQNTKLNesnvQLENKTsclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1322
Cdd:pfam05483  253 ENKMKDLTFLLEESRDKAN----QLEEKT---KLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKT 325

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1323 VKVLEEKLQAATSQLDAQQATNK-----------ELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKEN 1391
Cdd:pfam05483  326 ICQLTEEKEAQMEELNKAKAAHSfvvtefeattcSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEV 405

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1392 GLKELQGKLDESNTVLESQK---KSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1468
Cdd:pfam05483  406 ELEELKKILAEDEKLLDEKKqfeKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKL 485

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1469 FDTQLA--------EYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAyletKELRRQLESLELEKSREV 1540
Cdd:pfam05483  486 KNIELTahcdklllENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKE----MNLRDELESVREEFIQKG 561

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245   1541 LSLKAQMNgASSRSGKGDEVESLDIETSLA-----------KINFLNSIIADMQQKNDALKAK 1592
Cdd:pfam05483  562 DEVKCKLD-KSEENARSIEYEVLKKEKQMKilenkcnnlkkQIENKNKNIEELHQENKALKKK 623
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1360-1599 3.37e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 61.88  E-value: 3.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1360 NLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLA 1439
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1440 EQLSQLKQANEELQKSLQQKQLLLEkgnEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAY 1519
Cdd:COG1196  316 ERLEELEEELAELEEELEELEEELE---ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1520 LETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETL 1599
Cdd:COG1196  393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 404-1522 3.55e-09

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 61.99  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    404 INELKARIVELESALDNERKKTEELQCS----IDE--AQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILppd 477
Cdd:TIGR01612 1113 INKIKDDIKNLDQKIDHHIKALEEIKKKsenyIDEikAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKNIY--- 1189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    478 lpSDDGALQEEIAKLQEKMTIQQ----------KEVESRIAEQLEEEQRLRENVkylneqIATLQSELVSKDEALEKFSL 547
Cdd:TIGR01612 1190 --DEIKKLLNEIAEIEKDKTSLEevkginlsygKNLGKLFLEKIDEEKKKSEHM------IKAMEAYIEDLDEIKEKSPE 1261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    548 SECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSelqnLKATSDSLESERVNktDECEILQTEVRMRD 627
Cdd:TIGR01612 1262 IENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENISDIREKS----LKIIEDFSEESDIN--DIKKELQKNLLDAQ 1335

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    628 EQIRELNQQLDEVTTQLNVQKadssalddmlrlqkegteekstlLEKTEKELVQSKEQAaktlNDKEQLEKQISDlkQLA 707
Cdd:TIGR01612 1336 KHNSDINLYLNEIANIYNILK-----------------------LNKIKKIIDEVKEYT----KEIEENNKNIKD--ELD 1386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    708 EQEKLVREMTENAinQIQLEKESIEQQLALKqnELEDFQKKQSESEVHlqeIKAQNTQKDFELVESGESLKKLQQQLEQK 787
Cdd:TIGR01612 1387 KSEKLIKKIKDDI--NLEECKSKIESTLDDK--DIDECIKKIKELKNH---ILSEESNIDTYFKNADENNENVLLLFKNI 1459

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    788 TLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSaeseSALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLks 867
Cdd:TIGR01612 1460 EMADNKSQHILKIKKDNATNDHDFNINELKEHIDKS----KGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSAL-- 1533

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    868 qaeETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALE 947
Cdd:TIGR01612 1534 ---AIKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFENKFL 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    948 KVnkeyaesraeaSDLQDKVKE-ITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAwSQEMLQKEKELQE 1026
Cdd:TIGR01612 1611 KI-----------SDIKKKINDcLKETESIEKKISSFSIDSQDTELKENGDNLNSLQEFLESLKDQ-KKNIEDKKKELDE 1678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1027 LRQQLQdsqdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLE-LSTGTQTTIKDLQERLEITNAE-LQHKEKMASE 1104
Cdd:TIGR01612 1679 LDSEIE-------KIEIDVDQHKKNYEIGIIEKIKEIAIANKEEIEsIKELIEPTIENLISSFNTNDLEgIDPNEKLEEY 1751

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1105 DAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNS---ERLIEKVTGIKEELKEthl 1181
Cdd:TIGR01612 1752 NTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNTRINAQNEFLKIIEIEKKSKSyldDIEAKEFDRIINHFKK--- 1828

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1182 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKlteiqqslQELQDSVKQKEELVQNLEEKV-----RESSSIIEAQ 1256
Cdd:TIGR01612 1829 KLDHVNDKFTKEYSKINEGFDDISKSIENVKNSTDE--------NLLFDILNKTKDAYAGIIGKKyysykDEAEKIFINI 1900

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1257 NTKLNESNVQLENKT--SCLKETQDQLLESQKKEKqlqEEAAKLSGELQQVQEANGDIKDSLVKVEELVKvleeklqaat 1334
Cdd:TIGR01612 1901 SKLANSINIQIQNNSgiDLFDNINIAILSSLDSEK---EDTLKFIPSPEKEPEIYTKIRDSYDTLLDIFK---------- 1967

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1335 sqldAQQATNKELQELLvksqenegNLQGESLAVTEKLQQLEQANGELKEALCQKE---NGLKELQGKLDESN------- 1404
Cdd:TIGR01612 1968 ----KSQDLHKKEQDTL--------NIIFENQQLYEKIQASNELKDTLSDLKYKKEkilNDVKLLLHKFDELNklscdsq 2035

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1405 ---TVLESQKksHNEIQDKLEQAQQKERTL--QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKV 1479
Cdd:TIGR01612 2036 nydTILELSK--QDKIKEKIDNYEKEKEKFgiDFDVKAMEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKDNIIQSKKK 2113

                         1130      1140      1150      1160
                   ....*....|....*....|....*....|....*....|...
gi 28574245   1480 IDEMDDAASVKsalLEQLQNRVAELETALRQANDAQKTAYLET 1522
Cdd:TIGR01612 2114 LKELTEAFNTE---IKIIEDKIIEKNDLIDKLIEMRKECLLFS 2153
PTZ00121 PTZ00121
MAEBL; Provisional
 374-973 3.69e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 3.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   374 EKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTE----ELQCSIDEAQFCGDELNA---QS 446
Cdd:PTZ00121 1294 EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEaakaEAEAAADEAEAAEEKAEAaekKK 1373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   447 QVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEV-----------ESRIAEQLE--- 512
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKkkadeakkkaeEAKKADEAKkka 1453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   513 EEQRLRENVKYLNEQIATLQSelvSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLS 592
Cdd:PTZ00121 1454 EEAKKAEEAKKKAEEAKKADE---AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKA 1530

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   593 SE---LQNLKATSDSLESERVNKTDECEILQtEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKS 669
Cdd:PTZ00121 1531 EEakkADEAKKAEEKKKADELKKAEELKKAE-EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   670 TLLEKTEKELVQSKEqaaktLNDKEQLEKQISDLKQLAEQEK-----LVREMTENAINQIQLEKESIEQQLALKQNELED 744
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEE-----LKKAEEEKKKVEQLKKKEAEEKkkaeeLKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE 1684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   745 FQKKQSESEVHLQEIKAQNTQ----KDFELVESGESLKKLQQQLEQKTlghEKLQAALEELKKEKETIIKEKEQELQQLQ 820
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEEAKKAEelkkKEAEEKKKAEELKKAEEENKIKA---EEAKKEAEEDKKKAEEAKKDEEEKKKIAH 1761

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   821 SKSAESESALKVVQVQLEQLQQQAAASGE----EGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGS 896
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEkrrmEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNM 1841

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245   897 LEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANaALEKVNKEYAESRAEASDLQDKVKEITDT 973
Cdd:PTZ00121 1842 QLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEAD-EIEKIDKDDIEREIPNNNMAGKNNDIIDD 1917
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 661-894 3.87e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 3.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  661 QKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDL-KQLAEQEKLVREmTENAINQIQLEKESIEQQLALKQ 739
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALeRRIAALARRIRA-LEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  740 NELEDFQKKQSESEVHLQEIKAQNT------QKDFELVESG--------ESLKKLQQQLEQKTLGHEKLQAALEELKKEK 805
Cdd:COG4942   97 AELEAQKEELAELLRALYRLGRQPPlalllsPEDFLDAVRRlqylkylaPARREQAEELRADLAELAALRAELEAERAEL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  806 ETIIKEKEQELQQLQSKSAESESALKVVqvqleqlqqqaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEA 885
Cdd:COG4942  177 EALLAELEEERAALEALKAERQKLLARL------------------EKELAELAAELAELQQEAEELEALIARLEAEAAA 238


                 ....*....
gi 28574245  886 KSKQLEAAN 894
Cdd:COG4942  239 AAERTPAAG 247
PTZ00121 PTZ00121
MAEBL; Provisional
 487-1189 3.88e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 3.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   487 EEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKfslsecgiENLRRELELLKEEN 566
Cdd:PTZ00121 1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA--------EAEAAADEAEAAEE 1364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   567 EKQAQEAQAEFTRKLAE---KSVEVLRLSSELQNlKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQldevttq 643
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKKADaakKKAEEKKKADEAKK-KAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEA------- 1436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   644 lnVQKADSSALDDMLRLQKEGTEEKSTLLEKTEkelvqsKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQ 723
Cdd:PTZ00121 1437 --KKKAEEAKKADEAKKKAEEAKKAEEAKKKAE------EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEA 1508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   724 IQLEKESIEQQLALKQNELEDFQKKQSESEVH-LQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAAlEELK 802
Cdd:PTZ00121 1509 KKKADEAKKAEEAKKADEAKKAEEAKKADEAKkAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA-EEAK 1587

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   803 KEKETIIKEKEQELQQLQSKSAEsesalKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSN 882
Cdd:PTZ00121 1588 KAEEARIEEVMKLYEEEKKMKAE-----EAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   883 LEAKSKQleaangslEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASD 962
Cdd:PTZ00121 1663 AAEEAKK--------AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEE 1734

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   963 LQDKVKEitDTLHAElqaERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKElqelrqqlqdsqdsqtKLK 1042
Cdd:PTZ00121 1735 AKKEAEE--DKKKAE---EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDE----------------KRR 1793

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1043 AEGERKEKSFEESIKNLQEevtKAKTENLELSTGTQTTIKDLQERLEITNAELqhkekmasEDAQKIADLKTLVEAIQVA 1122
Cdd:PTZ00121 1794 MEVDKKIKDIFDNFANIIE---GGKEGNLVINDSKEMEDSAIKEVADSKNMQL--------EEADAFEKHKFNKNNENGE 1862

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245  1123 NANISATNAELSTVLEVLQAEKSETNHIFELfeMEADMNSERLIEKVTGIKEELKETHLQLDERQKK 1189
Cdd:PTZ00121 1863 DGNKEADFNKEKDLKEDDEEEIEEADEIEKI--DKDDIEREIPNNNMAGKNNDIIDDKLDKDEYIKR 1927
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 587-1338 3.94e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 61.78  E-value: 3.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    587 EVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNvQKADSSALDdmLRLQKEGTE 666
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWK-EKRDELNGE--LSAADAAVA 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    667 EKSTLLEKTEKELVQSKEQAAKTLN-DKEQLEKQISDLKQLAEQEKLVremtENAINQIQLEKESIEQQLALKQN-ELED 744
Cdd:pfam12128  319 KDRSELEALEDQHGAFLDADIETAAaDQEQLPSWQSELENLEERLKAL----TGKHQDVTAKYNRRRSKIKEQNNrDIAG 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    745 FQKKQSesevhlqeikAQNTQKDFELVESGESLKKLQQQLeqktlgHEKLQAALEELKKEKETIIKEKEQELQQLQSKSA 824
Cdd:pfam12128  395 IKDKLA----------KIREARDRQLAVAEDDLQALESEL------REQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    825 ESEsaLKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELK-------STQSNLEAKSKQLEAANGSL 897
Cdd:pfam12128  459 TPE--LLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRqasrrleERQSALDELELQLFPQAGTL 536

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    898 EEEAKKSGHLLEQitklksEVGETQAALSSCHTD-----VESKTKQ---LEAANAALEKVNKEyaesraEASDLQDKVKE 969
Cdd:pfam12128  537 LHFLRKEAPDWEQ------SIGKVISPELLHRTDldpevWDGSVGGelnLYGVKLDLKRIDVP------EWAASEEELRE 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    970 ITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQemlqKEKELQELRQQLqdsqdsqtklKAEGERKE 1049
Cdd:pfam12128  605 RLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKN----ARLDLRRLFDEK----------QSEKDKKN 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1050 KSFEESIKNLQEEVTKAKTENLELStgtqttiKDLQERLEitnaelQHKEKMASEDAQKIADLKTLVEAIQVANANISAT 1129
Cdd:pfam12128  671 KALAERKDSANERLNSLEAQLKQLD-------KKHQAWLE------EQKEQKREARTEKQAYWQVVEGALDAQLALLKAA 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1130 NAelstvlevlqaeKSETNHIFELFEMEADMNSERlieKVTGIKEElkethlQLDERQKKFEELEEKLKQAQQSEQKLQQ 1209
Cdd:pfam12128  738 IA------------ARRSGAKAELKALETWYKRDL---ASLGVDPD------VIAKLKREIRTLERKIERIAVRRQEVLR 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1210 -----------ESQTSKEKLTEIQQSLQELQDSVKQKEElvqnleekvresssiieaqNTKLNESNVQLENKTSclKETQ 1278
Cdd:pfam12128  797 yfdwyqetwlqRRPRLATQLSNIERAISELQQQLARLIA-------------------DTKLRRAKLEMERKAS--EKQQ 855

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1279 DQLLESQKKEKQLQEEAAKLSgELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLD 1338
Cdd:pfam12128  856 VRLSENLRGLRCEMSKLATLK-EDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVE 914
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 997-1598 4.48e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 4.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    997 DEIAtGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEK---------SFEESIKNLQEEVTKAK 1067
Cdd:TIGR02169  160 DEIA-GVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERyqallkekrEYEGYELLKEKEALERQ 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1068 TENLELSTGTQT-TIKDLQERLEITNAELQHKEKMASEDAQKIADL--------KTLVEAIQVANANISATNAELStvLE 1138
Cdd:TIGR02169  239 KEAIERQLASLEeELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgeeeqlrvKEKIGELEAEIASLERSIAEKE--RE 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1139 VLQAEKSETNHIFELFEMEADM-NSERLIE----KVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQT 1213
Cdd:TIGR02169  317 LEDAEERLAKLEAEIDKLLAEIeELEREIEeerkRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEK 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1214 SKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQE 1293
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1294 EAAKLSGELQQVQE--------------------ANGDIKDSLVK-----VEELVKVlEEKLQAAT-------------- 1334
Cdd:TIGR02169  477 EYDRVEKELSKLQRelaeaeaqaraseervrggrAVEEVLKASIQgvhgtVAQLGSV-GERYATAIevaagnrlnnvvve 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1335 SQLDAQQATN--KELQ---------------------------------------------------ELLVKSQEN---- 1357
Cdd:TIGR02169  556 DDAVAKEAIEllKRRKagratflplnkmrderrdlsilsedgvigfavdlvefdpkyepafkyvfgdTLVVEDIEAarrl 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1358 ---------EGNLQGESLAVT---EKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQ 1425
Cdd:TIGR02169  636 mgkyrmvtlEGELFEKSGAMTggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1426 QKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEkgnEFDTQLAEYQKVIDEMDDAasvksalLEQLQNRVAELE 1505
Cdd:TIGR02169  716 RKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE---NVKSELKELEARIEELEED-------LHKLEEALNDLE 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1506 TALRQAndaqktaylETKELRRQLESLELEKSREVLSLkAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQK 1585
Cdd:TIGR02169  786 ARLSHS---------RIPEIQAELSKLEEEVSRIEARL-REIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKE 855

                          730
                   ....*....|...
gi 28574245   1586 NDALKAKVQTLET 1598
Cdd:TIGR02169  856 IENLNGKKEELEE 868
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1089-1535 5.68e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1089 EITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANIsatnAELSTVLEVLQAEKSETNHIFELFEMEADMNS-ERLIE 1167
Cdd:COG4717   67 ELNLKELKELEEELKEAEEKEEEYAELQEELEELEEEL----EELEAELEELREELEKLEKLLQLLPLYQELEAlEAELA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1168 KVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQS-EQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKV 1246
Cdd:COG4717  143 ELPERLEELEERLEELRELEEELEELEAELAELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEEL 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1247 RESSSIIEaqntklnesnvQLENKtsclketqdqlLESQKKEKQLQEEAAKLS--GELQQVQEANGDIKDSLVKVEELVK 1324
Cdd:COG4717  223 EELEEELE-----------QLENE-----------LEAAALEERLKEARLLLLiaAALLALLGLGGSLLSLILTIAGVLF 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1325 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:COG4717  281 LVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELE 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1405 TVLEsQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEfDTQLAEYQKVIDEMD 1484
Cdd:COG4717  361 EELQ-LEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLE-ALDEEELEEELEELE 438

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1485 DAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETK--ELRRQLESLELE 1535
Cdd:COG4717  439 EELEELEEELEELREELAELEAELEQLEEDGELAELLQEleELKAELRELAEE 491
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1127-1468 7.04e-09

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 60.52  E-value: 7.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1127 SATNAELSTVLEVLQAEKS--ETNHIFELFEMEAdmnserlieKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSE 1204
Cdd:pfam05557    1 RAELIESKARLSQLQNEKKqmELEHKRARIELEK---------KASALKRQLDRESDRNQELQKRIRLLEKREAEAEEAL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1205 QKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLES 1284
Cdd:pfam05557   72 REQAELNRLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1285 QKKEKQLQEEAAKLSGELQQVQEANGDIKdSLVKVEELVKVLEEKLqAATSQLDAQQATNKELQELLVKSQENEGNLQGE 1364
Cdd:pfam05557  152 EQLRQNLEKQQSSLAEAEQRIKELEFEIQ-SQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIENKLLLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1365 SLAVTEKLQQLEQANGELKEALCQKENGLKELQG--KLDESNTVlesQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1442
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSwvKLAQDTGL---NLRSPEDLSRRIEQLQQREIVLKEENSSLTSSA 306

                          330       340
                   ....*....|....*....|....*....
gi 28574245   1443 SQLKQANEELQ---KSLQQKQLLLEKGNE 1468
Cdd:pfam05557  307 RQLEKARRELEqelAQYLKKIEDLNKKLK 335
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1166-1547 9.47e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.17  E-value: 9.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1166 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQtSKEKLTEIQQSLQELQDSVKQKEELVQNLEEK 1245
Cdd:COG4717   73 LKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELEALEAELAELPERLEEL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1246 VRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKV 1325
Cdd:COG4717  152 EERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1326 LEEKL--QAATSQLDAQQATNKELQELLV---------KSQENEGNLQGESLAV------------TEKLQQLEQANG-E 1381
Cdd:COG4717  232 LENELeaAALEERLKEARLLLLIAAALLAllglggsllSLILTIAGVLFLVLGLlallflllarekASLGKEAEELQAlP 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1382 LKEALCQKE--NGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETS--KLAEQLSQLKQANEE----LQ 1453
Cdd:COG4717  312 ALEELEEEEleELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELeqEIAALLAEAGVEDEEelraAL 391

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1454 KSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASvksalLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1533
Cdd:COG4717  392 EQAEEYQELKEELEELEEQLEELLGELEELLEALD-----EEELEEELEELEEELEELEEELEELREELAELEAELEQLE 466

                        410
                 ....*....|....
gi 28574245 1534 LEKSREVLSLKAQM 1547
Cdd:COG4717  467 EDGELAELLQELEE 480
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 666-1536 9.83e-09

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 60.74  E-value: 9.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  666 EEKSTLLEKT---EKELVQSKEQAAktlNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQ--LALKQN 740
Cdd:COG3096  278 NERRELSERAlelRRELFGARRQLA---EEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVQTALRQQekIERYQE 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  741 ELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQL--------EQKTLGHEKLQA--ALEELK-------- 802
Cdd:COG3096  355 DLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLadyqqaldVQQTRAIQYQQAvqALEKARalcglpdl 434

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  803 -----KEKETIIKEKEQELQQ----LQSKSAESESALKVVqvqleqlqqqaaasgEEGSKTVAKLHDEISqlKSQAEETQ 873
Cdd:COG3096  435 tpenaEDYLAAFRAKEQQATEevleLEQKLSVADAARRQF---------------EKAYELVCKIAGEVE--RSQAWQTA 497

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  874 SELKSTQSNLEAKSKQLEAANGSLEEEAKksghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 953
Cdd:COG3096  498 RELLRRYRSQQALAQRLQQLRAQLAELEQ----RLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQA 573

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  954 AESRAEASDLQDKVKEITdTLHAELQAERSSSSALHTKLSKFSDEIatgHKELTSKAD--AWSQEMLQKEKELQELRQQL 1031
Cdd:COG3096  574 AEAVEQRSELRQQLEQLR-ARIKELAARAPAWLAAQDALERLREQS---GEALADSQEvtAAMQQLLEREREATVERDEL 649

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1032 QdsqdsqtklkaegERKEkSFEESIKNLQEevtKAKTENLELSTgtqttikdLQERLeitNAELQHK--EKMASEDAQKI 1109
Cdd:COG3096  650 A-------------ARKQ-ALESQIERLSQ---PGGAEDPRLLA--------LAERL---GGVLLSEiyDDVTLEDAPYF 701

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1110 -ADLKTLVEAIQVAnanisatnaELSTVLEVLQAEKSETNHIFeLFEMEADMNSERLIEKvtgikEELKETHL-QLDERQ 1187
Cdd:COG3096  702 sALYGPARHAIVVP---------DLSAVKEQLAGLEDCPEDLY-LIEGDPDSFDDSVFDA-----EELEDAVVvKLSDRQ 766

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1188 ---KKFEEL--------EEKLKqaqqseqKLQQESQTSKEKLTEIQQSLQELQdsvkqkeELVQNLEEKVRESSSII--- 1253
Cdd:COG3096  767 wrySRFPEVplfgraarEKRLE-------ELRAERDELAEQYAKASFDVQKLQ-------RLHQAFSQFVGGHLAVAfap 832

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1254 --EAQNTKLNESNVQLEnktsclketqDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIkdSLVK---VEELVKVLEE 1328
Cdd:COG3096  833 dpEAELAALRQRRSELE----------RELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQA--NLLAdetLADRLEELRE 900

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1329 KLQAATSQ---LDAQQATNKELQELLVKSQ---ENEGNLQGESLAVTEKLQQLEQANGELKEALCQKEN-GLKELQGKLD 1401
Cdd:COG3096  901 ELDAAQEAqafIQQHGKALAQLEPLVAVLQsdpEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHfSYEDAVGLLG 980

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1402 ESNTVLESqkkshneIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLekgNEFDTQLAEYQKVID 1481
Cdd:COG3096  981 ENSDLNEK-------LRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTL---QELEQELEELGVQAD 1050

                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 28574245 1482 emDDAAsvksallEQLQNRVAELETALRQaNDAQKTaYLETKELRRQLESLELEK 1536
Cdd:COG3096 1051 --AEAE-------ERARIRRDELHEELSQ-NRSRRS-QLEKQLTRCEAEMDSLQK 1094
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 400-1484 1.25e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 60.45  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    400 LQKNINELKArIVElESALDN--ERKKTEELQCSIDEAQfcgDEL-NAQSQVYKEKIHDLESKITKLVSATPSLQSILpp 476
Cdd:TIGR01612  673 IDALYNELSS-IVK-ENAIDNteDKAKLDDLKSKIDKEY---DKIqNMETATVELHLSNIENKKNELLDIIVEIKKHI-- 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    477 dlpsdDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRenvKYlNEQIATLQSELvskdealekfslsecgieNLR 556
Cdd:TIGR01612  746 -----HGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELN---KY-KSKISEIKNHY------------------NDQ 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    557 RELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECeilQTEVRMRDEQIREL-NQ 635
Cdd:TIGR01612  799 INIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNC---KEKIDSEHEQFAELtNK 875

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    636 QLDEVT-TQLNVQKA---DSSALDDMLRLQKEGTEEKSTLLEKTEK--ELVQSKEQAAKTLNDK-----EQLEKQISDLK 704
Cdd:TIGR01612  876 IKAEISdDKLNDYEKkfnDSKSLINEINKSIEEEYQNINTLKKVDEyiKICENTKESIEKFHNKqnilkEILNKNIDTIK 955

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    705 QLAEQEKLVREMTENA-INQI-QLEKesieqqlALKQNELEDFQKKQSESEVHLQEIKAQ-NTQKDFELVESGESLKKLQ 781
Cdd:TIGR01612  956 ESNLIEKSYKDKFDNTlIDKInELDK-------AFKDASLNDYEAKNNELIKYFNDLKANlGKNKENMLYHQFDEKEKAT 1028

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    782 QQLEQKTlghEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESesalkvvQVQLEQLQQQAAASGEEGSKTVAKLHDE 861
Cdd:TIGR01612 1029 NDIEQKI---EDANKNIPNIEIAIHTSIYNIIDEIEKEIGKNIEL-------LNKEILEEAEINITNFNEIKEKLKHYNF 1098

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    862 ISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSghlleqitklksevgetqaalsschtdvESKTKQLEA 941
Cdd:TIGR01612 1099 DDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKALEEIKKKS----------------------------ENYIDEIKA 1150

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    942 ANAALEKVnkeyaesrAEASDLQDKVKEITDTLHaELQAERSSSSALHTKLSKFSDEIATGHKELTSkadawsqemLQKE 1021
Cdd:TIGR01612 1151 QINDLEDV--------ADKAISNDDPEEIEKKIE-NIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTS---------LEEV 1212

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1022 KELQeLRQQLQDSQDSQTKLKAEGERKE---KSFEESIKNLQEevTKAKTENLELSTGTQTTIKDLQERLEITNAELQHK 1098
Cdd:TIGR01612 1213 KGIN-LSYGKNLGKLFLEKIDEEKKKSEhmiKAMEAYIEDLDE--IKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDH 1289

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1099 EKMASEDAQKIADLKTLVEAIQVAN---ANISATNAELSTVLEVLQAEKSETN----HIFELFEMEADMNSERLIEKVTG 1171
Cdd:TIGR01612 1290 HIISKKHDENISDIREKSLKIIEDFseeSDINDIKKELQKNLLDAQKHNSDINlylnEIANIYNILKLNKIKKIIDEVKE 1369

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1172 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQ-KLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESS 1250
Cdd:TIGR01612 1370 YTKEIEENNKNIKDELDKSEKLIKKIKDDINLEEcKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENN 1449

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1251 siieaQNTKLNESNVQL-ENKTSCLKETQ------------DQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLV 1317
Cdd:TIGR01612 1450 -----ENVLLLFKNIEMaDNKSQHILKIKkdnatndhdfniNELKEHIDKSKGCKDEADKNAKAIEKNKELFEQYKKDVT 1524

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1318 KVEELVKVLEEKLQAATSQLDAQQATN--KELQELLV----KSQENEGNLQGESLAVTEKLQQLEQANgelkEALCQKEN 1391
Cdd:TIGR01612 1525 ELLNKYSALAIKNKFAKTKKDSEIIIKeiKDAHKKFIleaeKSEQKIKEIKKEKFRIEDDAAKNDKSN----KAAIDIQL 1600

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1392 GLKELQGKLDESNTVlesqKKSHNEIQDKLEQAQQKERTLQEET--SKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEF 1469
Cdd:TIGR01612 1601 SLENFENKFLKISDI----KKKINDCLKETESIEKKISSFSIDSqdTELKENGDNLNSLQEFLESLKDQKKNIEDKKKEL 1676

                         1130
                   ....*....|....*
gi 28574245   1470 DTQLAEYQKVIDEMD 1484
Cdd:TIGR01612 1677 DELDSEIEKIEIDVD 1691
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1163-1541 1.44e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.78  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1163 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSK--EKLTEIQQSLQELQ---DSVKQKEE 1237
Cdd:COG4717   77 EEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPerlEELEERLE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1238 LVQNLEEKVRESSSIIEAQNTKLNESNVQLENKT-SCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSL 1316
Cdd:COG4717  157 ELRELEEELEELEAELAELQEELEELLEQLSLATeEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENEL 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1317 VKVEELVKVLEEK-LQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALcQKENGLKE 1395
Cdd:COG4717  237 EAAALEERLKEARlLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEEL-QALPALEE 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1396 LQGKldESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQkslqQKQLLLEKGNEFDTQLAE 1475
Cdd:COG4717  316 LEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQE----IAALLAEAGVEDEEELRA 389

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245 1476 YQKVIDEMDDAAsvksALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVL 1541
Cdd:COG4717  390 ALEQAEEYQELK----EELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEEL 451
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 873-1559 1.49e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 59.97  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  873 QSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTdvesKTKQLEAANAALEKvnke 952
Cdd:COG3096  353 QEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQT----RAIQYQQAVQALEK---- 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  953 yAESRAEASDL-QDKVKEITDTLHAELQAERSSSSALHTKLSkFSDEIATGHKEL----------TSKADAWS--QEMLq 1019
Cdd:COG3096  425 -ARALCGLPDLtPENAEDYLAAFRAKEQQATEEVLELEQKLS-VADAARRQFEKAyelvckiageVERSQAWQtaRELL- 501

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1020 keKELQELRQQLQDSQDSQTKLkAEGERKEKSfEESIKNLQEEVTKAKTENLElstgTQTTIKDLQERLEITNAELqhkE 1099
Cdd:COG3096  502 --RRYRSQQALAQRLQQLRAQL-AELEQRLRQ-QQNAERLLEEFCQRIGQQLD----AAEELEELLAELEAQLEEL---E 570

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1100 KMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfemeadmNSERLIEKVTGIKEELKET 1179
Cdd:COG3096  571 EQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQDALERLREQSGEALA--------DSQEVTAAMQQLLEREREA 642

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1180 HLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEK-----LTEIQQ--SLQE----------------LQDSVKQKE 1236
Cdd:COG3096  643 TVERDELAARKQALESQIERLSQPGGAEDPRLLALAERlggvlLSEIYDdvTLEDapyfsalygparhaivVPDLSAVKE 722

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1237 ELvQNLEEkVRESSSIIEAQNTKLNES--NVQLENKTSCLKETQDQL-------------------LESQKKEK-QLQEE 1294
Cdd:COG3096  723 QL-AGLED-CPEDLYLIEGDPDSFDDSvfDAEELEDAVVVKLSDRQWrysrfpevplfgraarekrLEELRAERdELAEQ 800

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1295 AAKLSGELQQVQEANGDIKDSLVK---------VEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQG-- 1363
Cdd:COG3096  801 YAKASFDVQKLQRLHQAFSQFVGGhlavafapdPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKll 880

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1364 --------ESLAvtEKLQQLEQANGELKEA---LCQKENGLKELQGKLDesntVLESQKKSHNEIQDKLEQAQQKERTLQ 1432
Cdd:COG3096  881 pqanlladETLA--DRLEELREELDAAQEAqafIQQHGKALAQLEPLVA----VLQSDPEQFEQLQADYLQAKEQQRRLK 954

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1433 EETSKLAE---------------QLSQLKQANEELQKSLQQKQLLLEKGNE----FDTQLAEYQKVIDEMDDAASVKSAL 1493
Cdd:COG3096  955 QQIFALSEvvqrrphfsyedavgLLGENSDLNEKLRARLEQAEEARREAREqlrqAQAQYSQYNQVLASLKSSRDAKQQT 1034

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245 1494 LEQLQNRVAELEtaLRQANDAQKTAYLETKELRRQLESL-----ELEKSREVlsLKAQMNGASSRSGKGDE 1559
Cdd:COG3096 1035 LQELEQELEELG--VQADAEAEERARIRRDELHEELSQNrsrrsQLEKQLTR--CEAEMDSLQKRLRKAER 1101
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 125-185 1.55e-08

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 59.70  E-value: 1.55e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245  125 IGQRVWLGGTRpGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSR 185
Cdd:COG5244    6 VNDRVLLGDKF-GTVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIR 65
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
672-1408 1.74e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.54  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  672 LEKTEKELVQSKEQAaKTLndkEQLEKQISDLKQLAEQEKLVREM--------TENAINQIQLEKESIEQQLALKQNELE 743
Cdd:COG4913  237 LERAHEALEDAREQI-ELL---EPIRELAERYAAARERLAELEYLraalrlwfAQRRLELLEAELEELRAELARLEAELE 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  744 DFQKKQSESEVHLQEIKAQNTQKDfelvesGESLKKLQQQLEQKTLGHEKLQAALEELkkeketiikekEQELQQLQSKS 823
Cdd:COG4913  313 RLEARLDALREELDELEAQIRGNG------GDRLEQLEREIERLERELEERERRRARL-----------EALLAALGLPL 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  824 AESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSE---LKSTQSNLEAKS----KQLEAANGS 896
Cdd:COG4913  376 PASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEiasLERRKSNIPARLlalrDALAEALGL 455

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  897 LEEEAKKSGHLLEqitkLKSEVGETQAA----LSSCHTD--VESktkqlEAANAALEKVNKEYAESRaeasdLQ-DKVKE 969
Cdd:COG4913  456 DEAELPFVGELIE----VRPEEERWRGAiervLGGFALTllVPP-----EHYAAALRWVNRLHLRGR-----LVyERVRT 521

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  970 ITDTLHAELQAERSSSSALHTKLSKFSDEIatgHKELTSKADAWSQEmlqkekELQELRQqlqdsqdsqtklkaegerke 1049
Cdd:COG4913  522 GLPDPERPRLDPDSLAGKLDFKPHPFRAWL---EAELGRRFDYVCVD------SPEELRR-------------------- 572

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1050 ksfeesiknlqeeVTKAKTENLELSTGTQTTIKDLQERLEitnAELQhkekMASEDAQKIADLKTLVEAIQVANANISAT 1129
Cdd:COG4913  573 -------------HPRAITRAGQVKGNGTRHEKDDRRRIR---SRYV----LGFDNRAKLAALEAELAELEEELAEAEER 632

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1130 NAELSTVLEVLQAEKSETNHIFELFEMEADMNSerLIEKVTGIKEELKethlQLDERQKKFEELEEKLKQAQQSEQKLQQ 1209
Cdd:COG4913  633 LEALEAELDALQERREALQRLAEYSWDEIDVAS--AEREIAELEAELE----RLDASSDDLAALEEQLEELEAELEELEE 706

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1210 ESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVResssiiEAQNTKLnesnvqlenktsclketqDQLLESQKKEK 1289
Cdd:COG4913  707 ELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR------LELRALL------------------EERFAAALGDA 762

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1290 QLQEEAAKLSGELQQVQEANGDikdslvKVEELVKVLEEKLQ---AATSQLDAQQATNKELQELLVKsqenegnLQGESL 1366
Cdd:COG4913  763 VERELRENLEERIDALRARLNR------AEEELERAMRAFNRewpAETADLDADLESLPEYLALLDR-------LEEDGL 829

                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*
gi 28574245 1367 AVTEK--LQQLEQANGELKEALCQK-ENGLKELQGKLDESNTVLE 1408
Cdd:COG4913  830 PEYEErfKELLNENSIEFVADLLSKlRRAIREIKERIDPLNDSLK 874
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1016-1528 2.06e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.35  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1016 EMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKaktenlelSTGTQTTIKDLQERLEITNAEL 1095
Cdd:pfam05483  100 ELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKE--------NNATRHLCNLLKETCARSAEKT 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1096 QHKEKMASEDAQKIADLKTLVEAIQVA--NANISATNAELSTVLEvLQAEKSETNHIFELFEMEADMNSER---LIEKVT 1170
Cdd:pfam05483  172 KKYEYEREETRQVYMDLNNNIEKMILAfeELRVQAENARLEMHFK-LKEDHEKIQHLEEEYKKEINDKEKQvslLLIQIT 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1171 GIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESS 1250
Cdd:pfam05483  251 EKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLT 330

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1251 SIIEAQNTKLNESN-------VQLENKTSCLKE---TQDQLLEsqKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVE 1320
Cdd:pfam05483  331 EEKEAQMEELNKAKaahsfvvTEFEATTCSLEEllrTEQQRLE--KNEDQLKIITMELQKKSSELEEMTKFKNNKEVELE 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1321 ELVKVLEEKlqaaTSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGK- 1399
Cdd:pfam05483  409 ELKKILAED----EKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEk 484

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1400 ------LDESNTVLESQKKSHNEIQD---KLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQ-KQLLLEKGNEF 1469
Cdd:pfam05483  485 lknielTAHCDKLLLENKELTQEASDmtlELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESvREEFIQKGDEV 564

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245   1470 DTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQ 1528
Cdd:pfam05483  565 KCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKK 623
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1186-1598 2.15e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 59.26  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1186 RQKKFEELEEKLKQAQ----QSEQKL-------------------------QQESQ------TSKEKLTEIQQSLQELQD 1230
Cdd:TIGR04523   31 QDTEEKQLEKKLKTIKnelkNKEKELknldknlnkdeekinnsnnkikileQQIKDlndklkKNKDKINKLNSDLSKINS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1231 SVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANG 1310
Cdd:TIGR04523  111 EIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNID 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1311 DIKDSLVKVEELVKVLEEKLQ---AATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALC 1387
Cdd:TIGR04523  191 KIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLS 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1388 QKENGLKELQGKLDESN----------TVLESQKKS--HNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS 1455
Cdd:TIGR04523  271 EKQKELEQNNKKIKELEkqlnqlkseiSDLNNQKEQdwNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKE 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1456 LQQKQLlleKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDaqktaylETKELRRQLESLELE 1535
Cdd:TIGR04523  351 LTNSES---ENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEK-------LNQQKDEQIKKLQQE 420

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245   1536 KSrevLSLKAQMNGASSRSGKGDEVESLDIETSLAK--INFLNSIIADMQQKNDALKAKVQTLET 1598
Cdd:TIGR04523  421 KE---LLEKEIERLKETIIKNNSEIKDLTNQDSVKEliIKNLDNTRESLETQLKVLSRSINKIKQ 482
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 367-1306 2.38e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 59.03  E-value: 2.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    367 SMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALdneRKKTEELQCSIDEAQfcgDELNAQS 446
Cdd:pfam01576  187 AMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQL---AKKEEELQAALARLE---EETAQKN 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    447 QVYKeKIHDLESKITKLvsatpslqsilppdlpsddgalqeeiaklqekmtiqQKEVESRIAEQLEEEQRLRENVKYLNE 526
Cdd:pfam01576  261 NALK-KIRELEAQISEL------------------------------------QEDLESERAARNKAEKQRRDLGEELEA 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    527 QIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLE 606
Cdd:pfam01576  304 LKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    607 SERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLN-VQKADSSALDDMLRLQKEgTEEKSTLLEKTEKELVQSKEQ 685
Cdd:pfam01576  384 SENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSeSERQRAELAEKLSKLQSE-LESVSSLLNEAEGKNIKLSKD 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    686 AAktlndkeQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQnTQ 765
Cdd:pfam01576  463 VS-------SLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK-LE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    766 KDFELVESG-ESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQA 844
Cdd:pfam01576  535 EDAGTLEALeEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    845 AASgeegsktvAKLHDEISQLKSQAEETQSELKSTqsnleakSKQLEAANGSLEEeakksghLLEQITKLKSEVGEtqaa 924
Cdd:pfam01576  615 AIS--------ARYAEERDRAEAEAREKETRALSL-------ARALEEALEAKEE-------LERTNKQLRAEMED---- 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    925 LSSCHTDVESKTKQLEAANAALEkvnkeyaesrAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHK 1004
Cdd:pfam01576  669 LVSSKDDVGKNVHELERSKRALE----------QQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDE 738

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1005 ELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTenlelstgTQTTIKDL 1084
Cdd:pfam01576  739 QGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK--------LQAQMKDL 810

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1085 QERLEITNAELQHKEKMASEDAQKI----ADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfemeadm 1160
Cdd:pfam01576  811 QRELEEARASRDEILAQSKESEKKLknleAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD-------- 882

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1161 NSERLIEKVTGIKEELKETHLQ---LDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKL----TEIQQSLQELQDSVK 1233
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNtelLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLerqnKELKAKLQEMEGTVK 962

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574245   1234 QKEEL-VQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQ 1306
Cdd:pfam01576  963 SKFKSsIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLK 1036
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 800-1464 2.42e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 59.29  E-value: 2.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    800 ELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGS-------KTVAKLHDEISQL------- 865
Cdd:TIGR00606  109 EFKTLEGVITRYKHGEKVSLSSKCAEIDREMISHLGVSKAVLNNVIFCHQEDSnwplsegKALKQKFDEIFSAtryikal 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    866 ----------KSQAEETQSELKSTQSNLEAKSK---QLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHtDV 932
Cdd:TIGR00606  189 etlrqvrqtqGQKVQEHQMELKYLKQYKEKACEirdQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIM-KL 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    933 ESKTKQLEAANAALEKVNKEYAESRAEA-SDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKAD 1011
Cdd:TIGR00606  268 DNEIKALKSRKKQMEKDNSELELKMEKVfQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLV 347

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1012 AWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEnlELSTGTQTTikdlqerleit 1091
Cdd:TIGR00606  348 EQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQED--EAKTAAQLC----------- 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1092 nAELQHKEKMASEDAQKIADLKT-LVEAIQVANANISATNAELSTVLEVLQaeksetnhifelfemEADMNSERLIEKvt 1170
Cdd:TIGR00606  415 -ADLQSKERLKQEQADEIRDEKKgLGRTIELKKEILEKKQEELKFVIKELQ---------------QLEGSSDRILEL-- 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1171 giKEELKETHLQLDERQKKfeELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESS 1250
Cdd:TIGR00606  477 --DQELRKAERELSKAEKN--SLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIR 552

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1251 SIIEAQNTKLNESNVQLENKtsclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKL 1330
Cdd:TIGR00606  553 KIKSRHSDELTSLLGYFPNK----KQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKL 628

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1331 QAATSQlDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLE--------------QANGELKEALCQKENGLKEL 1396
Cdd:TIGR00606  629 FDVCGS-QDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTdenqsccpvcqrvfQTEAELQEFISDLQSKLRLA 707

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245   1397 QGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLE 1464
Cdd:TIGR00606  708 PDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLG 775
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1279-1550 2.96e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.77  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1279 DQLLEsqkkEKQLQEEAAKLSGELQQVQEAngdiKDSLVKVEELVKVLE------EKLQAATSQLDAQQATnKELQELLV 1352
Cdd:COG4913  215 EYMLE----EPDTFEAADALVEHFDDLERA----HEALEDAREQIELLEpirelaERYAAARERLAELEYL-RAALRLWF 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1353 KSQENEgnlqgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvLESQKKSHNeiQDKLEQAQQKERTLQ 1432
Cdd:COG4913  286 AQRRLE--------LLEAELEELRAELARLEAELERLEARLDALREELDE----LEAQIRGNG--GDRLEQLEREIERLE 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1433 EETSKLAEQLSQLKQANEELqkslqqkqlllekGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQAN 1512
Cdd:COG4913  352 RELEERERRRARLEALLAAL-------------GLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLR 418

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 28574245 1513 DaqktaylETKELRRQLESLELEKS---REVLSLKAQMNGA 1550
Cdd:COG4913  419 R-------ELRELEAEIASLERRKSnipARLLALRDALAEA 452
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 628-831 3.17e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  628 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQisdlkqLA 707
Cdd:COG4942   27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE------LE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  708 EQEKLVREMtenaINQIQLEKESIEQQLALKQNELEDFQKKQSesevHLQEIKAQNTQKDFELVESGESLKKLQQQLEQK 787
Cdd:COG4942  101 AQKEELAEL----LRALYRLGRQPPLALLLSPEDFLDAVRRLQ----YLKYLAPARREQAEELRADLAELAALRAELEAE 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 28574245  788 TLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALK 831
Cdd:COG4942  173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA 216
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1328-1557 3.20e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1328 EKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVL 1407
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1408 ESQKKSHNEIQDKLEQAQQKERTL----QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEM 1483
Cdd:COG4942  100 EAQKEELAELLRALYRLGRQPPLAlllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574245 1484 DDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKG 1557
Cdd:COG4942  180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKG 253
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
372-920 3.29e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.54  E-value: 3.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   372 LREKQQHVEKLMVERDLDRE---DAQNQALQLQKNINELKARIVELESALDNERKKTEELQ------CSIDEAQFCGDEL 442
Cdd:PRK03918  219 LREELEKLEKEVKELEELKEeieELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEekvkelKELKEKAEEYIKL 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   443 NAQSQVYKEKIHDLESKITKLVSATPSLQSILppdlpSDDGALQEEIAKLQEKMtiqqKEVESRIAEqLEEEQRLRENVK 522
Cdd:PRK03918  299 SEFYEEYLDELREIEKRLSRLEEEINGIEERI-----KELEEKEERLEELKKKL----KELEKRLEE-LEERHELYEEAK 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   523 YLNEQIATLQSELvsKDEALEKFslsecgienlrrelellkEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATS 602
Cdd:PRK03918  369 AKKEELERLKKRL--TGLTPEKL------------------EKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAI 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   603 DSLESERvnktDECEILQTEvrMRDEQIRELnqqLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKtEKELVQS 682
Cdd:PRK03918  429 EELKKAK----GKCPVCGRE--LTEEHRKEL---LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKL 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   683 KEQAAKTLNDKEQLEK-QISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKqNELEDFQKKQSESEVHLQEIKA 761
Cdd:PRK03918  499 KELAEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK-KKLAELEKKLDELEEELAELLK 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   762 QNTQKDFELVESGES-LKKLQ----QQLEQKTLGHEkLQAALEELKKEKETiIKEKEQELQQLQSKSAESESALKVVQVQ 836
Cdd:PRK03918  578 ELEELGFESVEELEErLKELEpfynEYLELKDAEKE-LEREEKELKKLEEE-LDKAFEELAETEKRLEELRKELEELEKK 655

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   837 -LEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANgSLEEEAKKSGHLLEQITKLK 915
Cdd:PRK03918  656 ySEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYK 734


                  ....*
gi 28574245   916 SEVGE 920
Cdd:PRK03918  735 ALLKE 739
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1059-1549 4.16e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.31  E-value: 4.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1059 LQEEVTKAKTENLELST------GTQTTIKDLQERLEITNAELqhKEKMASEDAQkiadlktlveaiqvANANISATNAE 1132
Cdd:pfam12128  246 LQQEFNTLESAELRLSHlhfgykSDETLIASRQEERQETSAEL--NQLLRTLDDQ--------------WKEKRDELNGE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1133 LSTVLEVLQAEKSEtnhiFELFEMEADMNSERLIEKVTGIKEelkethlQLDERQKKFEELEEKLKQAQQSEQKLQQESQ 1212
Cdd:pfam12128  310 LSAADAAVAKDRSE----LEALEDQHGAFLDADIETAAADQE-------QLPSWQSELENLEERLKALTGKHQDVTAKYN 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1213 TSKEKLteiqqSLQELQDSVKQKEELVQNLEEKVR---ESSSIIEAQNTKLNEsnvqlenktsclkETQDQLLESQKKEK 1289
Cdd:pfam12128  379 RRRSKI-----KEQNNRDIAGIKDKLAKIREARDRqlaVAEDDLQALESELRE-------------QLEAGKLEFNEEEY 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1290 QLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQqatnKELQELLVKSQENEGNLQGESLAVT 1369
Cdd:pfam12128  441 RLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQ----SELRQARKRRDQASEALRQASRRLE 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1370 EKLQQLEQAN-------GELKEALCQKENGLKELQGKL---------------------DESN---TVLESQKKSHNEIQ 1418
Cdd:pfam12128  517 ERQSALDELElqlfpqaGTLLHFLRKEAPDWEQSIGKVispellhrtdldpevwdgsvgGELNlygVKLDLKRIDVPEWA 596

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1419 DKLEQAQQK----ERTLQEETSKLAEQLSQLKQANEELQKS---------------LQQKQLLLEKGNEFDT---QLAEY 1476
Cdd:pfam12128  597 ASEEELRERldkaEEALQSAREKQAAAEEQLVQANGELEKAsreetfartalknarLDLRRLFDEKQSEKDKknkALAER 676

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245   1477 QK-VIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRR-QLESLELEKSREVLSLKAQMNG 1549
Cdd:pfam12128  677 KDsANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDaQLALLKAAIAARRSGAKAELKA 751
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1045-1504 4.86e-08

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 58.17  E-value: 4.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1045 GERKE-KSFEESIKNLQEEVTKAKT-----------ENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQK-IAD 1111
Cdd:COG5022  807 GSRKEyRSYLACIIKLQKTIKREKKlreteevefslKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqLQE 886

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1112 LKTLVEAIQvanaNISATNAEL-STVLEVLQAEKS----ETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDER 1186
Cdd:COG5022  887 LKIDVKSIS----SLKLVNLELeSEIIELKKSLSSdlieNLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNKLHEV 962

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1187 QKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESnvq 1266
Cdd:COG5022  963 ESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQLKELPVEVAELQSASKIISSES--- 1039

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1267 leNKTSCLKETQDQLLESQKKEKQLQEEAAKLsgelqQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKE 1346
Cdd:COG5022 1040 --TELSILKPLQKLKGLLLLENNQLQARYKAL-----KLRRENSLLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKPA 1112

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1347 -LQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEAlcqkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQA- 1424
Cdd:COG5022 1113 nVLQFIVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVL-------QLELDGLFWEANLEALPSPPPFAALSEKRLYQs 1185

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1425 ---QQKERTLQEETSKLAEQLSQL-KQANEELQKSLQQKQLLLEK--GNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQ 1498
Cdd:COG5022 1186 alyDEKSKLSSSEVNDLKNELIALfSKIFSGWPRGDKLKKLISEGwvPTEYSTSLKGFNNLNKKFDTPASMSNEKLLSLL 1265


                 ....*.
gi 28574245 1499 NRVAEL 1504
Cdd:COG5022 1266 NSIDNL 1271
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1175-1385 5.53e-08

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 57.15  E-value: 5.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1175 ELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIE 1254
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1255 AQNTKLNESNVQLENKT-----------SCLKETQDQLLESQKKEK-QLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1322
Cdd:COG3883   97 RSGGSVSYLDVLLGSESfsdfldrlsalSKIADADADLLEELKADKaELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1323 VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEA 1385
Cdd:COG3883  177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1049-1553 5.53e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.00  E-value: 5.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1049 EKSFEESIKNLQEEVtkaktENLElstGTQTTIKDLQERLEITNAELQHKEKMAsEDAQKIADLKTLVEAIQVANANISA 1128
Cdd:COG4913  220 EPDTFEAADALVEHF-----DDLE---RAHEALEDAREQIELLEPIRELAERYA-AARERLAELEYLRAALRLWFAQRRL 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1129 tnAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIE-----------KVTGIKEELKETHLQLDERQKKFEELEEKL 1197
Cdd:COG4913  291 --ELLEAELEELRAELARLEAELERLEARLDALREELDEleaqirgnggdRLEQLEREIERLERELEERERRRARLEALL 368

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1198 KQAQQSE-------QKLQQESQTSKEKLTEIQQSLQELQDSVKQKEelvQNLEEKVRESSSIIEAqntklnesnvqLENK 1270
Cdd:COG4913  369 AALGLPLpasaeefAALRAEAAALLEALEEELEALEEALAEAEAAL---RDLRRELRELEAEIAS-----------LERR 434

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1271 TSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDS------------LV------KVEELV--------- 1323
Cdd:COG4913  435 KSNIPARLLALRDALAEALGLDEAELPFVGELIEVRPEEERWRGAiervlggfaltlLVppehyaAALRWVnrlhlrgrl 514

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1324 ---KVLEEKLQAATSQLDAQQATNK----------ELQELLVKSQ-----ENEGNLQGESLAVTEKLQ------------ 1373
Cdd:COG4913  515 vyeRVRTGLPDPERPRLDPDSLAGKldfkphpfraWLEAELGRRFdyvcvDSPEELRRHPRAITRAGQvkgngtrhekdd 594

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1374 --------QLEQANGELKEALcQKEngLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKE---------RTLQEETS 1436
Cdd:COG4913  595 rrrirsryVLGFDNRAKLAAL-EAE--LAELEEELAEAEERLEALEAELDALQERREALQRLAeyswdeidvASAEREIA 671

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1437 KLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQK 1516
Cdd:COG4913  672 ELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALL 751

                        570       580       590
                 ....*....|....*....|....*....|....*..
gi 28574245 1517 TAYLETKELRRQLESLELEKSREVLSLKAQMNGASSR 1553
Cdd:COG4913  752 EERFAAALGDAVERELRENLEERIDALRARLNRAEEE 788
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
899-1521 9.90e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 9.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  899 EEAKKSGHLLEQITKLKSEVGETQAALSSCHT-----DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDT 973
Cdd:COG4913  245 EDAREQIELLEPIRELAERYAAARERLAELEYlraalRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREE 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  974 LhAELQAERSSSsalhtklskfsdeiatGHKELtskaDAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFE 1053
Cdd:COG4913  325 L-DELEAQIRGN----------------GGDRL----EQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFA 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1054 ESIKNLQEEVTKAKTE---NLELSTGTQTTIKDLQERLEITNAELQH---------------KEKMASEDAQKIADLKTL 1115
Cdd:COG4913  384 ALRAEAAALLEALEEEleaLEEALAEAEAALRDLRRELRELEAEIASlerrksniparllalRDALAEALGLDEAELPFV 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1116 VEAIQVANANISATNA-E----------------LSTVLEVLQAEKSETNHIFELFE--------MEADMNSerLIEKVT 1170
Cdd:COG4913  464 GELIEVRPEEERWRGAiErvlggfaltllvppehYAAALRWVNRLHLRGRLVYERVRtglpdperPRLDPDS--LAGKLD 541

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1171 gIK------------------------EELKE---------------THLQLDERQKKFEEL------EEKLKQAQQSEQ 1205
Cdd:COG4913  542 -FKphpfrawleaelgrrfdyvcvdspEELRRhpraitragqvkgngTRHEKDDRRRIRSRYvlgfdnRAKLAALEAELA 620

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1206 KLQQESQTSKEKLTEIQQSLQELQdsvkQKEELVQNLEEKVRESSSIIEAQnTKLNESNVQLENktscLKETQDQLLESQ 1285
Cdd:COG4913  621 ELEEELAEAEERLEALEAELDALQ----ERREALQRLAEYSWDEIDVASAE-REIAELEAELER----LDASSDDLAALE 691

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1286 KKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATN--KELQELLVKSQENE--GNL 1361
Cdd:COG4913  692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALleERFAAALGDAVERElrENL 771

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1362 QGESLAVTEKLQQLEQANGELKEALCQK-ENGLKELQGKLDEsntvLESQKKSHNEIQ-DKLEQAQQKERTLQEETS--K 1437
Cdd:COG4913  772 EERIDALRARLNRAEEELERAMRAFNREwPAETADLDADLES----LPEYLALLDRLEeDGLPEYEERFKELLNENSieF 847

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1438 LAEQLSQLKQANEE-------LQKSLQQKQ------LLLEKGNEFDTQLAEYQKVIDEMDDAASVKSA-LLEQLQNRVAE 1503
Cdd:COG4913  848 VADLLSKLRRAIREikeridpLNDSLKRIPfgpgryLRLEARPRPDPEVREFRQELRAVTSGASLFDEeLSEARFAALKR 927

                        730
                 ....*....|....*...
gi 28574245 1504 LETALRQANDAQKTAYLE 1521
Cdd:COG4913  928 LIERLRSEEEESDRRWRA 945
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1166-1559 1.22e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 56.90  E-value: 1.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1166 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESqtskEKLTEIQQSLQELQDSVKQKEELVQNLEEK 1245
Cdd:pfam02463  144 IEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELI----IDLEELKLQELKLKEQAKKALEYYQLKEKL 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1246 VRESSSIIEAQNTKLNESNvqlenktscLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKV 1325
Cdd:pfam02463  220 ELEEEYLLYLDYLKLNEER---------IDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1326 LEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNT 1405
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1406 VLESQKKSHNEIQDKLEQAQ---QKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE 1482
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAklkEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245   1483 mddAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAqMNGASSRSGKGDE 1559
Cdd:pfam02463  451 ---EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLK-VLLALIKDGVGGR 523
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1041-1546 1.44e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 56.29  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1041 LKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQttikDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQ 1120
Cdd:pfam05557   14 LQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQ----ELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALN 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1121 VANANISATNAELSTVLEVLQAEKSETNHIFelfeMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQA 1200
Cdd:pfam05557   90 KKLNEKESQLADAREVISCLKNELSELRRQI----QRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1201 QQSEQKLQQESQ--TSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEaQNTKLNESNVQLENKTSCLKETQ 1278
Cdd:pfam05557  166 AEAEQRIKELEFeiQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNENIE-NKLLLKEEVEDLKRKLEREEKYR 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1279 DQL----LESQKKEKQLQE-------------EAAKLSGELQQVQ-------EANGDIKDSLVKVEELVKVLEEKLQAAT 1334
Cdd:pfam05557  245 EEAatleLEKEKLEQELQSwvklaqdtglnlrSPEDLSRRIEQLQqreivlkEENSSLTSSARQLEKARRELEQELAQYL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1335 SQLDAQQATNKELQELLVKSQE------NEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN---T 1405
Cdd:pfam05557  325 KKIEDLNKKLKRHKALVRRLQRrvllltKERDGYRAILESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEaqlS 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1406 VLESQKKSHNEIQDKLEQAQQ--KERTLQEETSKLAEQLSQLKQANEELQkslQQKQLLLEKGNEFDTQLA--EYQKVID 1481
Cdd:pfam05557  405 VAEEELGGYKQQAQTLERELQalRQQESLADPSYSKEEVDSLRRKLETLE---LERQRLREQKNELEMELErrCLQGDYD 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1482 E------------MDDAASVKSALLEQLQNRV-----------AELETALRQANDAQKTAYLETKELRRQLESLEL--EK 1536
Cdd:pfam05557  482 PkktkvlhlsmnpAAEAYQQRKNQLEKLQAEIerlkrllkkleDDLEQVLRLPETTSTMNFKEVLDLRKELESAELknQR 561

                          570
                   ....*....|
gi 28574245   1537 SREVLSLKAQ 1546
Cdd:pfam05557  562 LKEVFQAKIQ 571
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
736-1226 1.58e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  736 ALKQNELEDFQKKQSESEVHLQEIKAQNTQKDfELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKE-- 813
Cdd:COG4717   50 RLEKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQll 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  814 ---QELQQLQSKSAESESALKVVqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQSELKstqsnlEAKSKQL 890
Cdd:COG4717  129 plyQELEALEAELAELPERLEEL---------------EERLEELRELEEELEELEAELAELQEELE------ELLEQLS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  891 EAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAAlEKVNKEYAESRAEAS--DLQDKVK 968
Cdd:COG4717  188 LATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE-ERLKEARLLLLIAAAllALLGLGG 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  969 EITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAegerk 1048
Cdd:COG4717  267 SLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE----- 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1049 eksFEESIKNLQEEVTKAKTENLELstgtqttikdLQERLEITNAELQHKEKMASED-----AQKIADLKTLVEAIQVAN 1123
Cdd:COG4717  342 ---LLDRIEELQELLREAEELEEEL----------QLEELEQEIAALLAEAGVEDEEelraaLEQAEEYQELKEELEELE 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1124 ANISATNAELSTVLEVLQAEKSETnhifELFEMEADMNS-----ERLIEKVTGIKEELK--ETHLQLDERQKKFEELEEK 1196
Cdd:COG4717  409 EQLEELLGELEELLEALDEEELEE----ELEELEEELEEleeelEELREELAELEAELEqlEEDGELAELLQELEELKAE 484

                        490       500       510
                 ....*....|....*....|....*....|
gi 28574245 1197 LKQAQQSEQKLQQESQTSKEKLTEIQQSLQ 1226
Cdd:COG4717  485 LRELAEEWAALKLALELLEEAREEYREERL 514
PRK11281 PRK11281
mechanosensitive channel MscK;
1275-1518 1.98e-07

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 56.07  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1275 KETQDQLlESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLE---EKLQAATSQLDAQQATNKElqell 1351
Cdd:PRK11281   39 ADVQAQL-DALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAqapAKLRQAQAELEALKDDNDE----- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1352 VKSQENEgnlqgeslavTEKLQQLEQangelkeALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKertL 1431
Cdd:PRK11281  113 ETRETLS----------TLSLRQLES-------RLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYANSQR---L 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1432 QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAE--------YQKVIDEMddaaSVKSALLEQ----LQN 1499
Cdd:PRK11281  173 QQIRNLLKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSLEgntqlqdlLQKQRDYL----TARIQRLEHqlqlLQE 248

                         250       260
                  ....*....|....*....|....
gi 28574245  1500 -----RVAELETALRQANDAQKTA 1518
Cdd:PRK11281  249 ainskRLTLSEKTVQEAQSQDEAA 272
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
668-1142 2.08e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.93  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  668 KSTLLEKTEKELVQSKEQAAKTLNdKEQLEKQISDLKQLAEQEKLVREMTEN--AINQIQLEKESIEQQLALKQNELEDF 745
Cdd:COG4717   36 KSTLLAFIRAMLLERLEKEADELF-KPQGRKPELNLKELKELEEELKEAEEKeeEYAELQEELEELEEELEELEAELEEL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  746 QKKQSESEVHLQeikaqntqkdfeLVESGESLKKLQQQLEQktlghekLQAALEELKkeketiikEKEQELQQLQSKSAE 825
Cdd:COG4717  115 REELEKLEKLLQ------------LLPLYQELEALEAELAE-------LPERLEELE--------ERLEELRELEEELEE 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  826 SESALKVVQVQLEQLQQQAAASGEEgskTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKsg 905
Cdd:COG4717  168 LEAELAELQEELEELLEQLSLATEE---ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE-- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  906 hllEQITKLKS--EVGETQAALSSCHTDVESKTKQLEAANAAL----------EKVNKEYAESRAEASDLQDKVKEITDT 973
Cdd:COG4717  243 ---ERLKEARLllLIAAALLALLGLGGSLLSLILTIAGVLFLVlgllallfllLAREKASLGKEAEELQALPALEELEEE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  974 LHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK--EKELQELRQQLQDSQDSQTKLKAEGERKEKS 1051
Cdd:COG4717  320 ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEelEQEIAALLAEAGVEDEEELRAALEQAEEYQE 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1052 FEESIKNLQEEVTKAKTENLELSTGTQTTikDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQvANANISATNA 1131
Cdd:COG4717  400 LKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREELAELEAELEQLE-EDGELAELLQ 476

                        490
                 ....*....|.
gi 28574245 1132 ELSTVLEVLQA 1142
Cdd:COG4717  477 ELEELKAELRE 487
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1006-1264 2.38e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.16  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1006 LTSKADAWSQEMLQKEKELQELRQQLQDSQdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELstgtQTTIKDLQ 1085
Cdd:COG4942   11 LALAAAAQADAAAEAEAELEQLQQEIAELE----KELAALKKEEKALLKQLAALERRIAALARRIRAL----EQELAALE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1086 ERLEITNAELQHKEKmaSEDAQKiADLKTLVEAIQvananisaTNAELSTVLEVLQAEKSetNHIFELFEMEADMNSERl 1165
Cdd:COG4942   83 AELAELEKEIAELRA--ELEAQK-EELAELLRALY--------RLGRQPPLALLLSPEDF--LDAVRRLQYLKYLAPAR- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1166 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEK 1245
Cdd:COG4942  149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228

                        250
                 ....*....|....*....
gi 28574245 1246 VRESSSIIEAQNTKLNESN 1264
Cdd:COG4942  229 IARLEAEAAAAAERTPAAG 247
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 852-1076 3.24e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  852 SKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTD 931
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  932 VESKTKQLEAANAALEKVNKEY-------AESRAEASDLQDKVKEITDTLHA---ELQAERSSSSALHTKLSKFSDEIAT 1001
Cdd:COG4942   99 LEAQKEELAELLRALYRLGRQPplalllsPEDFLDAVRRLQYLKYLAPARREqaeELRADLAELAALRAELEAERAELEA 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245 1002 GHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTG 1076
Cdd:COG4942  179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKG 253
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1140-1510 3.27e-07

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 54.90  E-value: 3.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1140 LQAEKSETNHIFELFEMeADMNSERLIEKVTGIKEELKETHLQLDERqkkFEELEEKLKQAQQSEQKLQQESQTSKEKLT 1219
Cdd:pfam07888   36 LEECLQERAELLQAQEA-ANRQREKEKERYKRDREQWERQRRELESR---VAELKEELRQSREKHEELEEKYKELSASSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1220 EIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLS 1299
Cdd:pfam07888  112 ELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLS 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1300 GELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKEL---QELLVKSQENEGNLqGESLAVTEKLQQLE 1376
Cdd:pfam07888  192 KEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELrslQERLNASERKVEGL-GEELSSMAAQRDRT 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1377 QAngELKEALCQkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERtlqeetSKLAEQLSQLKQANEELQKSL 1456
Cdd:pfam07888  271 QA--ELHQARLQ----AAQLTLQLADASLALREGRARWAQERETLQQSAEADK------DRIEKLSAELQRLEERLQEER 338

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245   1457 QQKQLL-LEKGNEFD---TQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQ 1510
Cdd:pfam07888  339 MEREKLeVELGREKDcnrVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQ 396
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 486-769 3.79e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.13  E-value: 3.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    486 QEEIAKLQEKMTIQQKevesRIAEQLEEEQRLRENVKYLNEQIATLqselVSKDEALEKFSLSECGIENLRRELELLKEE 565
Cdd:pfam17380  332 QAAIYAEQERMAMERE----RELERIRQEERKRELERIRQEEIAME----ISRMRELERLQMERQQKNERVRQELEAARK 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    566 NEKQAQEAQaeftRKLAEKSVEVLRLSSELQNLKATS-DSLESERVNktdECEILQTEVRMRDEQIRELNQQLDEvttql 644
Cdd:pfam17380  404 VKILEEERQ----RKIQQQKVEMEQIRAEQEEARQREvRRLEEERAR---EMERVRLEEQERQQQVERLRQQEEE----- 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    645 nvQKADSSALDDMLRLQKEGTEEKSTLLEKtekELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI 724
Cdd:pfam17380  472 --RKRKKLELEKEKRDRKRAEEQRRKILEK---ELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQ 546

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 28574245    725 QL-EKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFE 769
Cdd:pfam17380  547 EMeERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYE 592
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1153-1483 4.76e-07

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 54.47  E-value: 4.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1153 LFEMEADMNSERLIEkvtgIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQE----L 1228
Cdd:pfam06160   69 LFEAEELNDKYRFKK----AKKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELRKTLLAnrfsY 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1229 QDSVKQKEELVQNLEEK------VRESSSIIEAQNT--KLNESNVQLENKTS--------CLKETQDQLLESQKKEKQLQ 1292
Cdd:pfam06160  145 GPAIDELEKQLAEIEEEfsqfeeLTESGDYLEAREVleKLEEETDALEELMEdipplyeeLKTELPDQLEELKEGYREME 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1293 E-----EAAKLSGELQQVQEangDIKDSLVKVEEL-VKVLEEKLQAATSQLDAqqatnkeLQELLVKSQENEGNLQGESL 1366
Cdd:pfam06160  225 EegyalEHLNVDKEIQQLEE---QLEENLALLENLeLDEAEEALEEIEERIDQ-------LYDLLEKEVDAKKYVEKNLP 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1367 AVTEKLQQLEQANGELKE--ALCQKENGL--KELQgKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1442
Cdd:pfam06160  295 EIEDYLEHAEEQNKELKEelERVQQSYTLneNELE-RVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQL 373

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 28574245   1443 SQLKQANEELQKSLQQkqllLEKGnEFDTQ--LAEYQKVIDEM 1483
Cdd:pfam06160  374 EEIEEEQEEFKESLQS----LRKD-ELEARekLDEFKLELREI 411
PRK12704 PRK12704
phosphodiesterase; Provisional
 1139-1298 7.05e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 54.01  E-value: 7.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1139 VLQAEKsETNHIFELFEMEADMNSErliEKVTGIKEELK----ETHLQLDERQKKFEELEEKLkqaQQSEQKLQQESqts 1214
Cdd:PRK12704   33 IKEAEE-EAKRILEEAKKEAEAIKK---EALLEAKEEIHklrnEFEKELRERRNELQKLEKRL---LQKEENLDRKL--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1215 kEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssIIEAQNTKLNE-SNVQLEnktsclkETQDQLLESQKKEkqLQE 1293
Cdd:PRK12704  103 -ELLEKREEELEKKEKELEQKQQELEKKEEELEE---LIEEQLQELERiSGLTAE-------EAKEILLEKVEEE--ARH 169


                  ....*
gi 28574245  1294 EAAKL 1298
Cdd:PRK12704  170 EAAVL 174
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1022-1469 7.21e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.00  E-value: 7.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1022 KELQELRQQLQDSQDSQTKLKAEGERKEKSfEESIKNLQEEVTKAKTENLELSTGTQttIKDLQERLEITNAELQHKEKM 1101
Cdd:COG4717   71 KELKELEEELKEAEEKEEEYAELQEELEEL-EEELEELEAELEELREELEKLEKLLQ--LLPLYQELEALEAELAELPER 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1102 ASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETnhifelfemeadmnSERLIEKVTGIKEELKETHL 1181
Cdd:COG4717  148 LEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEE--------------LQDLAEELEELQQRLAELEE 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1182 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQS-LQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKL 1260
Cdd:COG4717  214 ELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAaLLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLL 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1261 NESNVQLENKT------SCLKETQDQLLESQKKEKQLQ-----EEAAKLSGELQQVQEANGDIKD-----SLVKVEELVK 1324
Cdd:COG4717  294 AREKASLGKEAeelqalPALEELEEEELEELLAALGLPpdlspEELLELLDRIEELQELLREAEEleeelQLEELEQEIA 373

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1325 VL--------EEKLQAATSQLDAQQATNKELQELlvKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKEL 1396
Cdd:COG4717  374 ALlaeagvedEEELRAALEQAEEYQELKEELEEL--EEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEEL 451

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245 1397 QGKLDESNTVLESQKKShneiqDKLEQAQQKERTLQEETSKLAEQ---LSQLKQANEELQKSLQQKQL--LLEKGNEF 1469
Cdd:COG4717  452 REELAELEAELEQLEED-----GELAELLQELEELKAELRELAEEwaaLKLALELLEEAREEYREERLppVLERASEY 524
PRK12704 PRK12704
phosphodiesterase; Provisional
 693-825 7.36e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 54.01  E-value: 7.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   693 KEQLEKQISDLKQLAEQeklvremtenAINQIQLEKESIEQQLALKQNELEDFQKKQSESEV-----HLQEIKAQNTQKD 767
Cdd:PRK12704   26 KKIAEAKIKEAEEEAKR----------ILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELrerrnELQKLEKRLLQKE 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245   768 FELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 825
Cdd:PRK12704   96 ENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE 153
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1182-1504 8.63e-07

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 54.29  E-value: 8.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1182 QLDERQkkfeeLEEKLKQAQQSEQKLQQES----QTSKEKLTEIQQSL---QELQDSVKQKEELVQNLEEKVRESSSiiE 1254
Cdd:PRK10929   22 APDEKQ-----ITQELEQAKAAKTPAQAEIvealQSALNWLEERKGSLeraKQYQQVIDNFPKLSAELRQQLNNERD--E 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1255 AQNTKLNESNVQLENKtscLKETQDQLLEsqkkekqlqeeaakLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAAT 1334
Cdd:PRK10929   95 PRSVPPNMSTDALEQE---ILQVSSQLLE--------------KSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1335 SQLDAQQATNKELQELLVKSqenegnLQGESLAVTEKLQQLE---------QANGELKEALCQKENglKELQGKLDESNT 1405
Cdd:PRK10929  158 RRLQTLGTPNTPLAQAQLTA------LQAESAALKALVDELElaqlsannrQELARLRSELAKKRS--QQLDAYLQALRN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1406 VLESQKkshneiQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSL-QQKQLLLEKGNEFDTQLAEYQKV----- 1479
Cdd:PRK10929  230 QLNSQR------QREAERALESTELLAEQSGDLPKSIVAQFKINRELSQALnQQAQRMDLIASQQRQAASQTLQVrqaln 303

                         330       340
                  ....*....|....*....|....*.
gi 28574245  1480 -IDEMDDAASVKSALLEQLQNRVAEL 1504
Cdd:PRK10929  304 tLREQSQWLGVSNALGEALRAQVARL 329
46 PHA02562
endonuclease subunit; Provisional
 702-974 1.15e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 53.48  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   702 DLKQLAEQEKL----VREMTENaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAqntqkdfELVESGESL 777
Cdd:PHA02562  161 DISVLSEMDKLnkdkIRELNQQ-IQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYD-------ELVEEAKTI 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   778 KklqQQLEQktlghekLQAALEELKKEKEtiikEKEQELQQLQSKSAESESALKvvqvqleqlqqqaaasgeegskTVAK 857
Cdd:PHA02562  233 K---AEIEE-------LTDELLNLVMDIE----DPSAALNKLNTAAAKIKSKIE----------------------QFQK 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   858 L------HDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKsevgETQAALSSCHTD 931
Cdd:PHA02562  277 VikmyekGGVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLL----ELKNKISTNKQS 352

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 28574245   932 VESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTL 974
Cdd:PHA02562  353 LITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTK 395
46 PHA02562
endonuclease subunit; Provisional
 1105-1321 1.16e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 53.48  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1105 DAQKIADLKTLVEA-IQVANANISATNAELSTVLEVLqaeKSETNHIFELfEMEADMNSERLIEKVTGIKEELKETHLQL 1183
Cdd:PHA02562  161 DISVLSEMDKLNKDkIRELNQQIQTLDMKIDHIQQQI---KTYNKNIEEQ-RKKNGENIARKQNKYDELVEEAKTIKAEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1184 DERQKKFEELEE----------KLKQAQ-------QSEQKL--------------QQESQTsKEKLTEIQQSLQELQDSV 1232
Cdd:PHA02562  237 EELTDELLNLVMdiedpsaalnKLNTAAakikskiEQFQKVikmyekggvcptctQQISEG-PDRITKIKDKLKELQHSL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1233 KQKEELVQNLEEKVREsssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI 1312
Cdd:PHA02562  316 EKLDTAIDELEEIMDE----FNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKI 391


                  ....*....
gi 28574245  1313 KDSLVKVEE 1321
Cdd:PHA02562  392 VKTKSELVK 400
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1174-1461 1.30e-06

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 52.22  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1174 EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1253
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1254 EAQNTKLNESNVQLENktscLKETQDQLLESQKKEKQLQEEAAKLSGElQQVQEANGDIKDSLVkveELVKVLEEKLQAA 1333
Cdd:COG1340   81 DELNEKLNELREELDE----LRKELAELNKAGGSIDKLRKEIERLEWR-QQTEVLSPEEEKELV---EKIKELEKELEKA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1334 TSQLDAqqatNKELQELLvksqenegnlqGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1413
Cdd:COG1340  153 KKALEK----NEKLKELR-----------AELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKE 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 28574245 1414 HNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQL 1461
Cdd:COG1340  218 IVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEEL 265
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1667-1683 1.30e-06

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 45.92  E-value: 1.30e-06
                           10
                   ....*....|....*..
gi 28574245   1667 RKYCDSCEVFGHDTSEC 1683
Cdd:pfam16641    1 RPYCEICEVFGHDTEDC 17
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 867-1093 1.35e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  867 SQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAAL 946
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  947 EKVNKEYAEsRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQE 1026
Cdd:COG4942  100 EAQKEELAE-LLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245 1027 LRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNA 1093
Cdd:COG4942  179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 660-1455 1.38e-06

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 53.68  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   660 LQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLaeqeklvremtENAINQIQLEKESIEQQLALKQ 739
Cdd:PTZ00440  839 LQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENMNKNINIIKTL-----------NIAINRSNSNKQLVEHLLNNKI 907

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   740 NELEDFQKkqsesevHLQEIKAQN----TQKDFELVESGESLKKLQQQLEQKTLGHEKLQA--ALEELKKEKETIIKEKE 813
Cdd:PTZ00440  908 DLKNKLEQ-------HMKIINTDNiiqkNEKLNLLNNLNKEKEKIEKQLSDTKINNLKMQIekTLEYYDKSKENINGNDG 980

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   814 QELQQLQSKSAESEsALKVVQVQLEQLQQQAAASGEEgskTVAKLHDEISQLksqaeeTQSELKSTQSNLEAKSKQLEAa 893
Cdd:PTZ00440  981 THLEKLDKEKDEWE-HFKSEIDKLNVNYNILNKKIDD---LIKKQHDDIIEL------IDKLIKEKGKEIEEKVDQYIS- 1049

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   894 ngSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEItdt 973
Cdd:PTZ00440 1050 --LLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDENKNKLIEIKNKSHEHVVNADKEKNKQTEH--- 1124

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   974 lhaeLQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFE 1053
Cdd:PTZ00440 1125 ----YNKKKKSLEKIYKQMEKTLKELENMNLEDITLNEVNEIEIEYERILIDHIVEQINNEAKKSKTIMEEIESYKKDID 1200

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1054 ESIKNLQEEvTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKmaSEDAQKIADLKT--------LVEAIQVANAn 1125
Cdd:PTZ00440 1201 QVKKNMSKE-RNDHLTTFEYNAYYDKATASYENIEELTTEAKGLKGE--ANRSTNVDELKEiklqvfsyLQQVIKENNK- 1276

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1126 ISATNAELSTVLEVLQAEKSET------NHIFELFEMEADMNSErlIEKVTGIKEELKETHLQLDERQKKFEELEEKlKQ 1199
Cdd:PTZ00440 1277 MENALHEIKNMYEFLISIDSEKilkeilNSTKKAEEFSNDAKKE--LEKTDNLIKQVEAKIEQAKEHKNKIYGSLED-KQ 1353

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1200 AQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEE-KVRESSSIIEAQNTKLNESNVQLENKTSCLKETQ 1278
Cdd:PTZ00440 1354 IDDEIKKIEQIKEEISNKRKEINKYLSNIKSNKEKCDLHVRNASRgKDKIDFLNKHEAIEPSNSKEVNIIKITDNINKCK 1433

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1279 DQLLESQKKEKQLQEEAAKLsgeLQQVQEANGDIKDSLVKVEElvKVLEEKLQAATSQLDAQQATNKELQELLVKSQENE 1358
Cdd:PTZ00440 1434 QYSNEAMETENKADENNDSI---IKYEKEITNILNNSSILGKK--TKLEKKKKEATNIMDDINGEHSIIKTKLTKSSEKL 1508

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1359 GNLQ--------GESLA---VTEKLQQLEQANGELKEALCQKENGLKELQ----------------GKLDESNTvLESQK 1411
Cdd:PTZ00440 1509 NQLNeqpnikreGDVLNndkSTIAYETIQYNLGRVKHNLLNILNIKDEIEtilnkaqdlmrdiskiSKIVENKN-LENLN 1587

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 28574245  1412 KSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS 1455
Cdd:PTZ00440 1588 DKEADYVKYLDNILKEKQLMEAEYKKLNEIYSDVDNIEKELKKH 1631
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
507-754 1.52e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.10  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  507 IAEQLEEEQ-RLRENVKYLNEQIATLQSELVSKDEALEKFslsecgienlrrelelLKEENEKQAQEAQAEFTRKLAEKS 585
Cdd:COG3206  162 LEQNLELRReEARKALEFLEEQLPELRKELEEAEAALEEF----------------RQKNGLVDLSEEAKLLLQQLSELE 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  586 VEVLRLSSELQNLKATSDSLESERVNKTDECEILQTevrmrDEQIRELNQQLDEVTTQLNVQKADSSALD-DMLRLQKEG 664
Cdd:COG3206  226 SQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAELAELSARYTPNHpDVIALRAQI 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  665 TEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQeklvremtenaINQIQLEKESIEQQLALKQNELED 744
Cdd:COG3206  301 AALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAE-----------LPELEAELRRLEREVEVARELYES 369

                        250
                 ....*....|
gi 28574245  745 FQKKQSESEV 754
Cdd:COG3206  370 LLQRLEEARL 379
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1193-1428 1.63e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.10  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1193 LEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELqdsvKQKEELVqNLEEKVRESSSIIEAQNTKLNESNVQLENKTS 1272
Cdd:COG3206  166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEF----RQKNGLV-DLSEEAKLLLQQLSELESQLAEARAELAEAEA 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1273 CLKETQDQLLESQKKEKQLQEEAAkLSGELQQVQEANGDIKDSLVKVEE---LVKVLEEKLQAATSQLDAqqatnkELQE 1349
Cdd:COG3206  241 RLAALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPnhpDVIALRAQIAALRAQLQQ------EAQR 313

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245 1350 LLVksqenegNLQGESLAVTEKLQQLEQANGELKEALcqkeNGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKE 1428
Cdd:COG3206  314 ILA-------SLEAELEALQAREASLQAQLAQLEARL----AELPELEAELRRLEREVEVARELYESLLQRLEEARLAE 381
PRK11281 PRK11281
mechanosensitive channel MscK;
413-823 2.22e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 52.61  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   413 ELESALD--NERKKTEE----LQCSIDEAQfcgdELNAQSQVYKEKIHDLESKITKlvsATPSLQSIlppdlpsddgalQ 486
Cdd:PRK11281   40 DVQAQLDalNKQKLLEAedklVQQDLEQTL----ALLDKIDRQKEETEQLKQQLAQ---APAKLRQA------------Q 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   487 EEIAKLQEKM---------TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSelvskdealekfslsecgienlrr 557
Cdd:PRK11281  101 AELEALKDDNdeetretlsTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQT------------------------ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   558 elellkeenekQAQEAQAEftrkLAEKSVEVLRLSSELQNLKATSDSLESERVNKtdeceiLQTEVRMRDEQIrELNQQL 637
Cdd:PRK11281  157 -----------QPERAQAA----LYANSQRLQQIRNLLKGGKVGGKALRPSQRVL------LQAEQALLNAQN-DLQRKS 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   638 DEVTTQLNvqkadssaldDMLRLQKEGTEEKSTLLEKT---------EKELVQSKEQAAKTLNDKE------------QL 696
Cdd:PRK11281  215 LEGNTQLQ----------DLLQKQRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEaariqanplvaqEL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   697 E--KQISD--------LKQLAEQEKLVREMTENAINQIQLEKESI--------------EQQLALKQNEL-EDFQKKQSE 751
Cdd:PRK11281  285 EinLQLSQrllkatekLNTLTQQNLRVKNWLDRLTQSERNIKEQIsvlkgslllsrilyQQQQALPSADLiEGLADRIAD 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   752 SEVHLQEIkaqNTQKDfELVESGESLKKLQQQleQKTLGHEKLQAALEELKKEKETIIKEKEQEL--------------Q 817
Cdd:PRK11281  365 LRLEQFEI---NQQRD-ALFQPDAYIDKLEAG--HKSEVTDEVRDALLQLLDERRELLDQLNKQLnnqlnlainlqlnqQ 438


                  ....*.
gi 28574245   818 QLQSKS 823
Cdd:PRK11281  439 QLLSVS 444
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 463-711 2.31e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  463 LVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMtiqqKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL 542
Cdd:COG4942   10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKEL----AALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  543 EKFSLSEcgienlrrelellkeeneKQAQEAQAEFTRKLAEKSVEVLRLS--SELQNLKATSDSLESERVNktdecEILQ 620
Cdd:COG4942   86 AELEKEI------------------AELRAELEAQKEELAELLRALYRLGrqPPLALLLSPEDFLDAVRRL-----QYLK 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  621 TEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKE-------GTEEKSTLLEKTEKELVQSKEQAAKTLNDK 693
Cdd:COG4942  143 YLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEeraaleaLKAERQKLLARLEKELAELAAELAELQQEA 222

                        250
                 ....*....|....*...
gi 28574245  694 EQLEKQISDLKQLAEQEK 711
Cdd:COG4942  223 EELEALIARLEAEAAAAA 240
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 580-826 2.95e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  580 KLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLR 659
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  660 LQKEgteEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQeklvREMTENAINQIQLEKESIEQQLALKQ 739
Cdd:COG4942  101 AQKE---ELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA----RREQAEELRADLAELAALRAELEAER 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  740 NELEDFQKKQSESEVHLQEIKAQNTQKdfelvesgesLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQL 819
Cdd:COG4942  174 AELEALLAELEEERAALEALKAERQKL----------LARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243


                 ....*..
gi 28574245  820 QSKSAES 826
Cdd:COG4942  244 PAAGFAA 250
PRK09039 PRK09039
peptidoglycan -binding protein;
618-757 3.09e-06

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 51.12  E-value: 3.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   618 ILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDML-RLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQL 696
Cdd:PRK09039   43 FLSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVaNLRAS--------LSAAEAERSRLQALLAELAGAGAAA 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245   697 EKQISDL-KQLAEQEKLvremTENAINQIQLEKESIEQ---QLALKQNELEDFQKKQSESEVHLQ 757
Cdd:PRK09039  115 EGRAGELaQELDSEKQV----SARALAQVELLNQQIAAlrrQLAALEAALDASEKRDRESQAKIA 175
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1274-1519 3.45e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 3.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1274 LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAtnkELQELLVK 1353
Cdd:COG3883   18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE---ELGERARA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1354 SQENEGNLQgeslavteKLQQLEQANGelkealcqkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQE 1433
Cdd:COG3883   95 LYRSGGSVS--------YLDVLLGSES------------FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1434 ETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQAND 1513
Cdd:COG3883  155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAA 234


                 ....*.
gi 28574245 1514 AQKTAY 1519
Cdd:COG3883  235 AAAAAA 240
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
658-1089 3.54e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.69  E-value: 3.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  658 LRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKEsiEQQLAL 737
Cdd:COG4717   83 AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEER--LEELRE 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  738 KQNELEDFQKKQSESEVHLQEIKAQNT-QKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKE--Q 814
Cdd:COG4717  161 LEEELEELEAELAELQEELEELLEQLSlATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEaaA 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  815 ELQQLQSK--SAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEA 892
Cdd:COG4717  241 LEERLKEArlLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  893 ANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVES-KTKQLEAANAALEK----VNKEYAESRAEASDLQDKV 967
Cdd:COG4717  321 LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEElQLEELEQEIAALLAeagvEDEEELRAALEQAEEYQEL 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  968 KEITDTLHAELQAERSSSSALHTKLSKfsDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGER 1047
Cdd:COG4717  401 KEELEELEEQLEELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQEL 478

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 28574245 1048 KEKsfEESIKNLQEEVTKAKTenlelstgTQTTIKDLQERLE 1089
Cdd:COG4717  479 EEL--KAELRELAEEWAALKL--------ALELLEEAREEYR 510
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1069-1550 3.85e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.15  E-value: 3.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1069 ENLELSTGTQ-TTIKDLQERLEITNAE--LQHKEKMASEDAQKIADLKTlVEAIQVANA--------NISATNAELSTVL 1137
Cdd:pfam12128  149 QNDRTLLGRErVELRSLARQFALCDSEspLRHIDKIAKAMHSKEGKFRD-VKSMIVAILeddgvvppKSRLNRQQVEHWI 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1138 EVLQAEKSETNHIFELFEMEADMNS-ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQaqqseqKLQQESQTSKE 1216
Cdd:pfam12128  228 RDIQAIAGIMKIRPEFTKLQQEFNTlESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQ------LLRTLDDQWKE 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1217 KLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIiEAQNTKLNESNV-QLENKTSCLKETQDQLLESQ---------K 1286
Cdd:pfam12128  302 KRDELNGELSAADAAVAKDRSELEALEDQHGAFLDA-DIETAAADQEQLpSWQSELENLEERLKALTGKHqdvtakynrR 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1287 KEKQLQEEAAKLSGeLQQVQEANGDIKDSLVKVEElvKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESL 1366
Cdd:pfam12128  381 RSKIKEQNNRDIAG-IKDKLAKIREARDRQLAVAE--DDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQAT 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1367 AVTEKLQQLEQANGEL---KEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL- 1442
Cdd:pfam12128  458 ATPELLLQLENFDERIeraREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLl 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1443 ----SQLKQANEELQKSLQQKQLLlekgnefdtqlaeyQKVIDEMDDAASVKSAL--------LEQLQ-NRVAELETALR 1509
Cdd:pfam12128  538 hflrKEAPDWEQSIGKVISPELLH--------------RTDLDPEVWDGSVGGELnlygvkldLKRIDvPEWAASEEELR 603

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 28574245   1510 QANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGA 1550
Cdd:pfam12128  604 ERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFA 644
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1276-1444 3.88e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.92  E-value: 3.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1276 ETQDQLLESQKKEKQLQE---EAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELL- 1351
Cdd:COG1579    4 EDLRALLDLQELDSELDRlehRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLg 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1352 -VKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKshnEIQDKLEQAQQKERT 1430
Cdd:COG1579   84 nVRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKA---ELDEELAELEAELEE 160

                        170
                 ....*....|....
gi 28574245 1431 LQEETSKLAEQLSQ 1444
Cdd:COG1579  161 LEAEREELAAKIPP 174
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 693-830 3.92e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.92  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  693 KEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQS------ESEVHLQEIKAQNTQK 766
Cdd:COG1579   26 LKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGnvrnnkEYEALQKEIESLKRRI 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245  767 DF---ELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAL 830
Cdd:COG1579  106 SDledEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKI 172
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1204-1460 4.44e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.56  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1204 EQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLeekvRESSSIIEAQNtklnESNVQLENktscLKETQDQLLE 1283
Cdd:COG3206  163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEF----RQKNGLVDLSE----EAKLLLQQ----LSELESQLAE 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1284 SQKKEKQLQEEAAKLSGELQQVQEANGDIKDSlvkveELVKVLEEKLQAATSQLDAQQATNKElqellvksqenegnlqg 1363
Cdd:COG3206  231 ARAELAEAEARLAALRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTP----------------- 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1364 ESLAVTEKLQQLEQANGELKEalcqkenglkELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEqLS 1443
Cdd:COG3206  289 NHPDVIALRAQIAALRAQLQQ----------EAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRR-LE 357

                        250
                 ....*....|....*..
gi 28574245 1444 QLKQANEELQKSLQQKQ 1460
Cdd:COG3206  358 REVEVARELYESLLQRL 374
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 581-917 4.63e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.75  E-value: 4.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    581 LAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRL 660
Cdd:pfam10174  361 LNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTT 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    661 QKEGTEEKSTLLEKTEKELVQSKEQAAKTLndkEQLEKQISDLKQ--------LAEQEKLVREMTENAINQIQ--LEKES 730
Cdd:pfam10174  441 LEEALSEKERIIERLKEQREREDRERLEEL---ESLKKENKDLKEkvsalqpeLTEKESSLIDLKEHASSLASsgLKKDS 517

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    731 ieqqlALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFEL-VESGESLKKLQQQLEQKTLGHEKLQAALEEL-------- 801
Cdd:pfam10174  518 -----KLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTnPEINDRIRLLEQEVARYKEESGKAQAEVERLlgilreve 592

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    802 --KKEKETIIKE---------KEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAE 870
Cdd:pfam10174  593 neKNDKDKKIAElesltlrqmKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELD 672

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 28574245    871 ETQSELKSTQSNLEAKSKQLEaangSLEEEAKKSghlLEQITKLKSE 917
Cdd:pfam10174  673 ATKARLSSTQQSLAEKDGHLT----NLRAERRKQ---LEEILEMKQE 712
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 759-1395 6.27e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.26  E-value: 6.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    759 IKAQNTQKD--FELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQ 836
Cdd:pfam05483  204 VQAENARLEmhFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDEN 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    837 LEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSleeeakKSGHLLeQITKLKS 916
Cdd:pfam05483  284 LKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKA------KAAHSF-VVTEFEA 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    917 EVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLhaelqAERSSSSALHTKLSKFS 996
Cdd:pfam05483  357 TTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKIL-----AEDEKLLDEKKQFEKIA 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    997 DEIATGHKELTSKADAwsqemlqKEKELQELRQQLQDSQDSqtklkaegerkEKSFEESIKNLQEEVTKAKTENLELSTG 1076
Cdd:pfam05483  432 EELKGKEQELIFLLQA-------REKEIHDLEIQLTAIKTS-----------EEHYLKEVEDLKTELEKEKLKNIELTAH 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1077 tqttikdlqerleiTNAELQHKEKMASEDAQKIADLKTLVEAIqvananISATNAELSTVLEVLQAEKSETNhifelFEM 1156
Cdd:pfam05483  494 --------------CDKLLLENKELTQEASDMTLELKKHQEDI------INCKKQEERMLKQIENLEEKEMN-----LRD 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1157 EADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1236
Cdd:pfam05483  549 ELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAEN 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1237 ELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQqvQEANGDIKDSL 1316
Cdd:pfam05483  629 KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEID--KRCQHKIAEMV 706

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245   1317 VKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKE 1395
Cdd:pfam05483  707 ALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1240-1522 6.82e-06

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 50.93  E-value: 6.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1240 QNLEEKvresssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQlqeeaAKLSGELQQVQEANGDIKDSLVKV 1319
Cdd:pfam18971  559 RNLENK-------LTAKGLSLQEANKLIKDFLSSNKELAGKALNFNKAVAE-----AKSTGNYDEVKKAQKDLEKSLRKR 626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1320 EELVKVLEEKLQAAT---SQLDAQQATNKELQEL--LVKSQENEG--------NLQGESLAVTEKLQQLEQANGELKEAL 1386
Cdd:pfam18971  627 EHLEKEVEKKLESKSgnkNKMEAKAQANSQKDEIfaLINKEANRDaraiaytqNLKGIKRELSDKLEKISKDLKDFSKSF 706

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1387 CQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLqqKQLLLEkg 1466
Cdd:pfam18971  707 DEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSV--KDVIIN-- 782

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245   1467 nefdtqlaeyQKVIDEMDD---AASVKSAL--LEQLQNRVAELETALRQ--ANDAQKTAYLET 1522
Cdd:pfam18971  783 ----------QKVTDKVDNlnqAVSVAKAMgdFSRVEQVLADLKNFSKEqlAQQAQKNEDFNT 835
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 412-1435 6.92e-06

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 51.37  E-value: 6.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   412 VELESALDNERKKTEELQCSIDEAQFCGDELNAQSQ---VYKEKIHDLESKITKLVSATP-SLQSILppDLPSDDGA--- 484
Cdd:PTZ00440  487 EKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKnieDYYITIEGLKNEIEGLIELIKyYLQSIE--TLIKDEKLkrs 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   485 LQEEIAK-----------------LQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSL 547
Cdd:PTZ00440  565 MKNDIKNkikyieenvdhikdiisLNDEIDNIIQQIEELINEALFNKEKFINEKNDLQEKVKYILNKFYKGDLQELLDEL 644

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   548 SECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVL-----RLSSELQNLKATSDSLESERVNKtdeceiLQTE 622
Cdd:PTZ00440  645 SHFLDDHKYLYHEAKSKEDLQTLLNTSKNEYEKLEFMKSDNIdniikNLKKELQNLLSLKENIIKKQLNN------IEQD 718

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   623 VRMRDEQIRElnqQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQL---EKQ 699
Cdd:PTZ00440  719 ISNSLNQYTI---KYNDLKSSIEEYKEEEEKLEVYKHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTIlnkENK 795

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   700 IS-DLKQLAEQEKLVREMTENAINQIQLEK-------ESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELV 771
Cdd:PTZ00440  796 ISnDINILKENKKNNQDLLNSYNILIQKLEahtekndEELKQLLQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENM 875

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   772 ESG-ESLKKLQQQLEqktlGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvqvqleqLQQQAAASGEE 850
Cdd:PTZ00440  876 NKNiNIIKTLNIAIN----RSNSNKQLVEHLLNNKIDLKNKLEQHMKIINTDNIIQKNE----------KLNLLNNLNKE 941

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   851 GSKTVAKLHDE-ISQLKSQAEETQSELKSTQSNLEAKSK-QLEaangSLEEEAKKSGHLLEQITKLKSEVGETQAALSSc 928
Cdd:PTZ00440  942 KEKIEKQLSDTkINNLKMQIEKTLEYYDKSKENINGNDGtHLE----KLDKEKDEWEHFKSEIDKLNVNYNILNKKIDD- 1016

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   929 hTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTS 1008
Cdd:PTZ00440 1017 -LIKKQHDDIIELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDE 1095

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1009 KADAWSQEMLQKEKELQELRQQLQdsqdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTqttikdlqerl 1088
Cdd:PTZ00440 1096 NKNKLIEIKNKSHEHVVNADKEKN-------KQTEHYNKKKKSLEKIYKQMEKTLKELENMNLEDITLN----------- 1157

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1089 EITNAELQHKEKMASEDAQKIAD-----------LKTLVEAIQVANANISATNAELSTVLEVLQAEKSETnhifelfemE 1157
Cdd:PTZ00440 1158 EVNEIEIEYERILIDHIVEQINNeakksktimeeIESYKKDIDQVKKNMSKERNDHLTTFEYNAYYDKAT---------A 1228

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1158 ADMNSERLIEKVTGIKEElkethlqlDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQ------------QSL 1225
Cdd:PTZ00440 1229 SYENIEELTTEAKGLKGE--------ANRSTNVDELKEIKLQVFSYLQQVIKENNKMENALHEIKnmyeflisidseKIL 1300

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1226 QELQDSVKQKEELVQNLEEKVRESSSIIEaqntklnesnvQLENKTSCLKETQDQLLESQkKEKQLQEEAAKLSGELQQV 1305
Cdd:PTZ00440 1301 KEILNSTKKAEEFSNDAKKELEKTDNLIK-----------QVEAKIEQAKEHKNKIYGSL-EDKQIDDEIKKIEQIKEEI 1368

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1306 QEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEklQQLEQANGELKEA 1385
Cdd:PTZ00440 1369 SNKRKEINKYLSNIKSNKEKCDLHVRNASRGKDKIDFLNKHEAIEPSNSKEVNIIKITDNINKCK--QYSNEAMETENKA 1446

                        1050      1060      1070      1080      1090      1100
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245  1386 LCQKENGLK-------------------ELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEET 1435
Cdd:PTZ00440 1447 DENNDSIIKyekeitnilnnssilgkktKLEKKKKEATNIMDDINGEHSIIKTKLTKSSEKLNQLNEQP 1515
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
372-804 8.53e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.83  E-value: 8.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   372 LREKQQHVEKlMVERDLDREDAQNQALQLQKNINELKAR-----IVELESALDNERKKTEELQCSIDEaqfcgdelnaqs 446
Cdd:PRK03918  343 LKKKLKELEK-RLEELEERHELYEEAKAKKEELERLKKRltgltPEKLEKELEELEKAKEEIEEEISK------------ 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   447 qvYKEKIHDLESKITKLVSATPSLQSIlPPDLPSDDGALQEEIAK-LQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLn 525
Cdd:PRK03918  410 --ITARIGELKKEIKELKKAIEELKKA-KGKCPVCGRELTEEHRKeLLEEYTAELKRIEKELKEIEEKERKLRKELREL- 485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   526 EQIATLQSELVSKDEALEKfslsecgIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSEL---QNLKATS 602
Cdd:PRK03918  486 EKVLKKESELIKLKELAEQ-------LKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELeklEELKKKL 558

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   603 DSLESERVNKTDECEILQTEVRMRD-EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEgteekstlLEKTEKELVQ 681
Cdd:PRK03918  559 AELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPFYNEYLELKDAEKELEREEKE--------LKKLEEELDK 630

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   682 SKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVRemtenainqIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKA 761
Cdd:PRK03918  631 AFEELAETEKRLEELRKELEELEKKYSEEEYEE---------LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE 701

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 28574245   762 QNTqkdfELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKE 804
Cdd:PRK03918  702 ELE----EREKAKKELEKLEKALERVEELREKVKKYKALLKER 740
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
706-927 9.70e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.40  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  706 LAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFqkKQSESEVHLQEIKAQNTQKdfelvesgesLKKLQQQLE 785
Cdd:COG3206  162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEF--RQKNGLVDLSEEAKLLLQQ----------LSELESQLA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  786 QKTLGHEKLQAALEELKKEKETIIKE-----KEQELQQLQSKSAESESALKVVQVQLEqlqqqaaasgeEGSKTVAKLHD 860
Cdd:COG3206  230 EARAELAEAEARLAALRAQLGSGPDAlpellQSPVIQQLRAQLAELEAELAELSARYT-----------PNHPDVIALRA 298

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245  861 EISQLKSQ----AEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSS 927
Cdd:COG3206  299 QIAALRAQlqqeAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYES 369
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1181-1372 1.08e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.77  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1181 LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSsiiEAQNTKL 1260
Cdd:COG1579   10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNVR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1261 NESNVQlenktSCLKEtqdqlLESQKKEKQLQEEaaklsgELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQ 1340
Cdd:COG1579   87 NNKEYE-----ALQKE-----IESLKRRISDLED------EILELMERIEELEEELAELEAELAELEAELEEKKAELDEE 150

                        170       180       190
                 ....*....|....*....|....*....|...
gi 28574245 1341 QA-TNKELQELLVKSQENEGNLQGESLAVTEKL 1372
Cdd:COG1579  151 LAeLEAELEELEAEREELAAKIPPELLALYERI 183
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 695-831 1.15e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.38  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  695 QLEKQISDL-KQLAEQEKLVREMtENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKaqnTQKDFELVES 773
Cdd:COG1579   21 RLEHRLKELpAELAELEDELAAL-EARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR---NNKEYEALQK 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245  774 G-ESLKKLQQQLEQKTLGH----EKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALK 831
Cdd:COG1579   97 EiESLKRRISDLEDEILELmeriEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
PRK12704 PRK12704
phosphodiesterase; Provisional
 1168-1352 1.34e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1168 KVTGIKEELKEThlqLDERQKKFEEL-EEKLKQAQQSEQKLQQE-SQTSKEKLTEIQQslqeLQDSVKQKEELVQNLEEK 1245
Cdd:PRK12704   32 KIKEAEEEAKRI---LEEAKKEAEAIkKEALLEAKEEIHKLRNEfEKELRERRNELQK----LEKRLLQKEENLDRKLEL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1246 VRESSSIIEAQNTKLNESNVQLENKtsclKETQDQLLESQKKEkqlQEEAAKLSGElqqvqEANgdikdslvkvEELVKV 1325
Cdd:PRK12704  105 LEKREEELEKKEKELEQKQQELEKK----EEELEELIEEQLQE---LERISGLTAE-----EAK----------EILLEK 162

                         170       180       190
                  ....*....|....*....|....*....|...
gi 28574245  1326 LEEKLQAATSQL------DAQQATNKELQELLV 1352
Cdd:PRK12704  163 VEEEARHEAAVLikeieeEAKEEADKKAKEILA 195
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
372-816 1.47e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.77  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  372 LREKQQHVEKLMVERDlDREDAQNQALQLQKNINELKARIVELESALDNER--KKTEELQCSIDEAQFCGDELNAQSQVY 449
Cdd:COG4717   80 LKEAEEKEEEYAELQE-ELEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEEL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  450 KEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQekmtiqqkEVESRIAEQLEEEQRLRENVKYLNEQIA 529
Cdd:COG4717  159 RELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE--------ELQQRLAELEEELEEAQEELEELEEELE 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  530 TLQSELVSKDEALEKFSLSE--------CGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKAT 601
Cdd:COG4717  231 QLENELEAAALEERLKEARLllliaaalLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQAL 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  602 SDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEvttqlnVQKADSSALDDMLRLQKEGTE-EKSTLLEKTEKELV 680
Cdd:COG4717  311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE------LQELLREAEELEEELQLEELEqEIAALLAEAGVEDE 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  681 QSKEQAAKTLNDKEQLEKQISDLK-QLAEQEKLVREMTENAI-NQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQE 758
Cdd:COG4717  385 EELRAALEQAEEYQELKEELEELEeQLEELLGELEELLEALDeEELEEELEELEEELEELEEELEELREELAELEAELEQ 464

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245  759 IKAQNtqkdfELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQEL 816
Cdd:COG4717  465 LEEDG-----ELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPV 517
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1102-1343 1.57e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1102 ASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQaeksetnhifelfemEADMNSERLIEKVTGIKEELKETHL 1181
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLA---------------ALERRIAALARRIRALEQELAALEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1182 QLDERQKKFEELEEKLKQAQQSEQK----LQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssiIEAQN 1257
Cdd:COG4942   84 ELAELEKEIAELRAELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEE----LRADL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1258 TKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQL 1337
Cdd:COG4942  160 AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239


                 ....*.
gi 28574245 1338 DAQQAT 1343
Cdd:COG4942  240 AERTPA 245
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 371-970 1.62e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 50.05  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    371 LLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVE--LESALDNERKKTEELQCSIDEAQFCGDELNAQSQV 448
Cdd:TIGR00606  369 LIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAqlCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEI 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    449 YKEKIHDLESKITKLVSATPSLQSILppdlpsddgalqeeiaKLQEKMTiqQKEVESRIAEQLEEEQRLRENVKYLNEQI 528
Cdd:TIGR00606  449 LEKKQEELKFVIKELQQLEGSSDRIL----------------ELDQELR--KAERELSKAEKNSLTETLKKEVKSLQNEK 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    529 ATLQSELVSKDEALEKfslsecgiENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESE 608
Cdd:TIGR00606  511 ADLDRKLRKLDQEMEQ--------LNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 582

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    609 RVnktdecEILQTEVRMRDEQ--IRELNQQLDEVTTQLNVQKADSSALDDMLrLQKEGTEEKSTLLEKTEKELVQSKEQA 686
Cdd:TIGR00606  583 SK------EINQTRDRLAKLNkeLASLEQNKNHINNELESKEEQLSSYEDKL-FDVCGSQDEESDLERLKEEIEKSSKQR 655

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    687 AKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQK 766
Cdd:TIGR00606  656 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGR 735

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    767 DFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQE---------LQQLQSKSAESESalKVVQVQL 837
Cdd:TIGR00606  736 QSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAkvcltdvtiMERFQMELKDVER--KIAQQAA 813

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    838 EQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQ---SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKL 914
Cdd:TIGR00606  814 KLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQeqiQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVEL 893

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    915 KSEVGETQAALSSCHT----DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEI 970
Cdd:TIGR00606  894 STEVQSLIREIKDAKEqdspLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNI 953
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1193-1468 1.67e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1193 LEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTS 1272
Cdd:COG4372   29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1273 CLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLV 1352
Cdd:COG4372  109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDEL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1353 KSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQ 1432
Cdd:COG4372  189 LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAIL 268

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 28574245 1433 EETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1468
Cdd:COG4372  269 VEKDTEEEELEIAALELEALEEAALELKLLALLLNL 304
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 378-1261 1.82e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.84  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    378 HVEKL---MVERDLDREDAQNQalqlqknineLKARIVELESALDNERKKTEELQCSIDEAQfcgdeLNAQSQVYKEKIH 454
Cdd:pfam12128  180 HIDKIakaMHSKEGKFRDVKSM----------IVAILEDDGVVPPKSRLNRQQVEHWIRDIQ-----AIAGIMKIRPEFT 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    455 DLESKITKLVSATPSLQSilppdlpsddgaLQEEIAKLQEKMTIQQKEVESRIAEQleeEQRLRENVKYLNEQIATLQSE 534
Cdd:pfam12128  245 KLQQEFNTLESAELRLSH------------LHFGYKSDETLIASRQEERQETSAEL---NQLLRTLDDQWKEKRDELNGE 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    535 LVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERV--NK 612
Cdd:pfam12128  310 LSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKeqNN 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    613 TDECEILQTEVRMRDEQIRelnqqldevttQLNVQKADSSALDDMLRLQKEG-----TEEKSTLLEKTEKELVQsKEQAA 687
Cdd:pfam12128  390 RDIAGIKDKLAKIREARDR-----------QLAVAEDDLQALESELREQLEAgklefNEEEYRLKSRLGELKLR-LNQAT 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    688 KTLNDKEQLEKQISDLKQLAE-QEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQK 766
Cdd:pfam12128  458 ATPELLLQLENFDERIERAREeQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLL 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    767 DFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQsksaesesalkvvqvqleqlqqqaaa 846
Cdd:pfam12128  538 HFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRID-------------------------- 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    847 sgeegsktVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKsghLLEQITKLKSEvGETQAALS 926
Cdd:pfam12128  592 --------VPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASRE---ETFARTALKNA-RLDLRRLF 659

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    927 SCHTDVESK-TKQLEAANA-ALEKVNKEYAESRAEASDLQDKVKEITDTL----HAELQAERSSSSALHTKLSKFSDEIA 1000
Cdd:pfam12128  660 DEKQSEKDKkNKALAERKDsANERLNSLEAQLKQLDKKHQAWLEEQKEQKrearTEKQAYWQVVEGALDAQLALLKAAIA 739

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1001 ---TGHKELTSKADAWSQEMLQK-----------EKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKA 1066
Cdd:pfam12128  740 arrSGAKAELKALETWYKRDLASlgvdpdviaklKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNI 819

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1067 KTENLELstgtQTTIKDLQERLEITNAELQhKEKMASEDAQ---------------KIADLKTLVEAIQvANANISATNA 1131
Cdd:pfam12128  820 ERAISEL----QQQLARLIADTKLRRAKLE-MERKASEKQQvrlsenlrglrcemsKLATLKEDANSEQ-AQGSIGERLA 893

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1132 ELSTVLEVLQAEKSETNHIFELFEM--------EADMNSERLIEKVTGIKEELkethLQLDERQKKFEELEEKLK-QAQQ 1202
Cdd:pfam12128  894 QLEDLKLKRDYLSESVKKYVEHFKNviadhsgsGLAETWESLREEDHYQNDKG----IRLLDYRKLVPYLEQWFDvRVPQ 969

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245   1203 SEQKLQQESQTSKEKLTEIQQSLQELQDSVK-QKEELVQNLE-----EKVRESSSIIEAQNTKLN 1261
Cdd:pfam12128  970 SIMVLREQVSILGVDLTEFYDVLADFDRRIAsFSRELQREVGeeaffEGVSESAVRIRSKVSELE 1034
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1189-1536 2.21e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.66  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1189 KFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKeelvQNLEEKVRESSSIIEAQNTKLNESNVQLE 1268
Cdd:TIGR00606  183 RYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSK----EAQLESSREIVKSYENELDPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1269 NKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQV-QEANGDIKDSLVKVEELVKVLEEKLQAATSQLdaqQATNKEL 1347
Cdd:TIGR00606  259 HNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVfQGTDEQLNDLYHNHQRTVREKERELVDCQREL---EKLNKER 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1348 QELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKE----------------LQGKLDESNTVlesqK 1411
Cdd:TIGR00606  336 RLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFErgpfserqiknfhtlvIERQEDEAKTA----A 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1412 KSHNEIQDKLEQAQQK-----------ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKvi 1480
Cdd:TIGR00606  412 QLCADLQSKERLKQEQadeirdekkglGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSK-- 489

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245   1481 deMDDAASVKSALLEQ--LQNRVAELETALRQanDAQKTAYLE-TKELRRQLESLELEK 1536
Cdd:TIGR00606  490 --AEKNSLTETLKKEVksLQNEKADLDRKLRK--LDQEMEQLNhHTTTRTQMEMLTKDK 544
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
907-1511 2.21e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  907 LLEQITKLKSEVGEtqaaLSSCHTDVESKTKQLEAAnAALEKVNKEYAESRAEASDLQD--------KVKEITDTLHAEL 978
Cdd:COG4913  223 TFEAADALVEHFDD----LERAHEALEDAREQIELL-EPIRELAERYAAARERLAELEYlraalrlwFAQRRLELLEAEL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  979 QAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLqdsqdsqTKLKAEGERKEKSFEESIKN 1058
Cdd:COG4913  298 EELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERL-------ERELEERERRRARLEALLAA 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1059 LQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVL- 1137
Cdd:COG4913  371 LGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALa 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1138 EVLQAEKSETNHIFELFEMEADMNS-----ERLI--------------EKVTGIKEELK-ETHLQLderqkkfeeleEKL 1197
Cdd:COG4913  451 EALGLDEAELPFVGELIEVRPEEERwrgaiERVLggfaltllvppehyAAALRWVNRLHlRGRLVY-----------ERV 519

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1198 KQAQQSEQKLQQESQTSKEKLT--------EIQQSLQELQDSVKqkeelVQNLEEKVRESSSI-IEAQ------------ 1256
Cdd:COG4913  520 RTGLPDPERPRLDPDSLAGKLDfkphpfraWLEAELGRRFDYVC-----VDSPEELRRHPRAItRAGQvkgngtrhekdd 594

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1257 NTKLNESNV-------QLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSG---ELQQVQEANGDIKDslvkveelVKVL 1326
Cdd:COG4913  595 RRRIRSRYVlgfdnraKLAALEAELAELEEELAEAEERLEALEAELDALQErreALQRLAEYSWDEID--------VASA 666

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1327 EEKLQAATSQLDAQQATNKELQELlvksQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE---- 1402
Cdd:COG4913  667 EREIAELEAELERLDASSDDLAAL----EEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAaedl 742

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1403 --SNTVLESQKKSHNEIQDKLEqaQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLekGNEFDTQLAEYQKVI 1480
Cdd:COG4913  743 arLELRALLEERFAAALGDAVE--RELRENLEERIDALRARLNRAEEELERAMRAFNREWPAE--TADLDADLESLPEYL 818

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 28574245 1481 DEMDDAASV---------KSALLEQLQNRVAELETALRQA 1511
Cdd:COG4913  819 ALLDRLEEDglpeyeerfKELLNENSIEFVADLLSKLRRA 858
46 PHA02562
endonuclease subunit; Provisional
 1080-1318 2.23e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 49.24  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1080 TIKDLQERLE-ITNAELQHKEKMASEDAQKIADLKTLVEAIQVAnanisatnaelstVLEVLQAEKSETNHIFELFEMEA 1158
Cdd:PHA02562  199 TYNKNIEEQRkKNGENIARKQNKYDELVEEAKTIKAEIEELTDE-------------LLNLVMDIEDPSAALNKLNTAAA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1159 DMNSErlIEKVTGIKEELKETHL------QLDERQKKFEELEEKLKQAQQSEQKL---QQESQTSKEKLTEIQQSLQELQ 1229
Cdd:PHA02562  266 KIKSK--IEQFQKVIKMYEKGGVcptctqQISEGPDRITKIKDKLKELQHSLEKLdtaIDELEEIMDEFNEQSKKLLELK 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1230 DSVKQKEELVQNLEEKVRESSSIIEaqntKLNESNVqleNKTSCLKETQDQLlesqkkeKQLQEEAAKLSGELQQVQEAN 1309
Cdd:PHA02562  344 NKISTNKQSLITLVDKAKKVKAAIE----ELQAEFV---DNAEELAKLQDEL-------DKIVKTKSELVKEKYHRGIVT 409


                  ....*....
gi 28574245  1310 GDIKDSLVK 1318
Cdd:PHA02562  410 DLLKDSGIK 418
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 368-1026 2.25e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.66  E-value: 2.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    368 MQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVE---LESALDNERKKTEELQCSidEAQFCGDELNA 444
Cdd:TIGR00606  417 LQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKElqqLEGSSDRILELDQELRKA--ERELSKAEKNS 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    445 QSQVYKEKIHDLESKitklvsatpslqsilPPDLPSDDGALQEEIAKLQEKMTiQQKEVESRIAEQLEEEQRLRENVKYL 524
Cdd:TIGR00606  495 LTETLKKEVKSLQNE---------------KADLDRKLRKLDQEMEQLNHHTT-TRTQMEMLTKDKMDKDEQIRKIKSRH 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    525 NEQIATLQSELVSKDEaLEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSEL------QNL 598
Cdd:TIGR00606  559 SDELTSLLGYFPNKKQ-LEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDE 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    599 KATSDSLESERVNKTDECEILQTEVRMRDEQIREL---NQQLDEVTTQLNVQKAD----SSALDDMLRLQKEGTEEKSTL 671
Cdd:TIGR00606  638 ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLtdeNQSCCPVCQRVFQTEAElqefISDLQSKLRLAPDKLKSTESE 717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    672 LEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQlaEQEKLVREMTE--NAINQIQLEKESIEQQLALKQNELED----- 744
Cdd:TIGR00606  718 LKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRN--KLQKVNRDIQRlkNDIEEQETLLGTIMPEEESAKVCLTDvtime 795

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    745 -FQKKQSESEVHLQEIKAQNTQKDFELvesgeSLKKLQQQLEQKTLGHEKLQAALEELKKeketIIKEKEQELQQLQSKS 823
Cdd:TIGR00606  796 rFQMELKDVERKIAQQAAKLQGSDLDR-----TVQQVNQEKQEKQHELDTVVSKIELNRK----LIQDQQEQIQHLKSKT 866

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    824 AESESAlKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 903
Cdd:TIGR00606  867 NELKSE-KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVND 945

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    904 SGHLLEQITKLKSEV------------GETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQD------ 965
Cdd:TIGR00606  946 IKEKVKNIHGYMKDIenkiqdgkddylKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDnltlrk 1025

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245    966 ---KVKEITDTLHAEL----QAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQE 1026
Cdd:TIGR00606 1026 renELKEVEEELKQHLkemgQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE 1093
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 686-903 2.41e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  686 AAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQ 765
Cdd:COG4942   15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  766 KDFELVESGESLKKL---QQQLEQKT-----------LGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALK 831
Cdd:COG4942   95 LRAELEAQKEELAELlraLYRLGRQPplalllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERA 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28574245  832 VVqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 903
Cdd:COG4942  175 EL---------------EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
392-591 3.05e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 3.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  392 DAQNQALQLQKNINELKARIVELES---ALDNERKKTEELQCSIDE-AQFCGDELNAQSqvYKEKIHDLESKITKLVSAT 467
Cdd:COG4913  607 DNRAKLAALEAELAELEEELAEAEErleALEAELDALQERREALQRlAEYSWDEIDVAS--AEREIAELEAELERLDASS 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  468 PSLQsilppdlpsddgALQEEIAKLQEkmtiQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSL 547
Cdd:COG4913  685 DDLA------------ALEEQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 28574245  548 SECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRL 591
Cdd:COG4913  749 ALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERA 792
PRK11281 PRK11281
mechanosensitive channel MscK;
975-1512 3.18e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 49.14  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   975 HAELQAERSSSSALHTKLSKFSD-EIATGHKELTSKADAWSQEMLQK----EKELQELRqqlqdsqdsqtKLKAEGERKE 1049
Cdd:PRK11281   28 RAASNGDLPTEADVQAQLDALNKqKLLEAEDKLVQQDLEQTLALLDKidrqKEETEQLK-----------QQLAQAPAKL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1050 KSFEESIKNLQEEVTKAKTENLElstgtQTTIKDLQERLEITNAELQhkekmaseDAQkiadlktlvEAIQVANANISAt 1129
Cdd:PRK11281   97 RQAQAELEALKDDNDEETRETLS-----TLSLRQLESRLAQTLDQLQ--------NAQ---------NDLAEYNSQLVS- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1130 naeLSTVLEVLQAEKSEtnhifelfemeadmNSERLiekvtgikeelkethlqlderqkkfEELEEKLKQAQQSEQKLQQ 1209
Cdd:PRK11281  154 ---LQTQPERAQAALYA--------------NSQRL-------------------------QQIRNLLKGGKVGGKALRP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1210 ESQTskekLTEIQQSLQELQDSVKQKE----ELVQNLEEKVREsssiieaqntKLNESNVQLEnktsclKETQD-QLLES 1284
Cdd:PRK11281  192 SQRV----LLQAEQALLNAQNDLQRKSlegnTQLQDLLQKQRD----------YLTARIQRLE------HQLQLlQEAIN 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1285 QKKEKQLQEEAAklsgELQQVQEANGDIKDSLVKveelvkvleeklqaatsqldAQQATNKELQELLVKSqenegnlqge 1364
Cdd:PRK11281  252 SKRLTLSEKTVQ----EAQSQDEAARIQANPLVA--------------------QELEINLQLSQRLLKA---------- 297

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1365 slavTEKLQQLEQANGELK---EALCQKENGLKE----LQGKLdesntVLesqkkshNEIqdkLEQAQQKERTLQeETSK 1437
Cdd:PRK11281  298 ----TEKLNTLTQQNLRVKnwlDRLTQSERNIKEqisvLKGSL-----LL-------SRI---LYQQQQALPSAD-LIEG 357

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245  1438 LAEQLSQLKQAneelQKSLQQKQLLLEKGNEFDTQLAEYQKVidEMDDAasVKSALLEQLQNRVAELETALRQAN 1512
Cdd:PRK11281  358 LADRIADLRLE----QFEINQQRDALFQPDAYIDKLEAGHKS--EVTDE--VRDALLQLLDERRELLDQLNKQLN 424
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1065-1421 3.75e-05

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 48.74  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1065 KAKTENLELSTGTQTTIKDLQERLEiTNAELQHKEKMASEDAQKIADlkTLVEAIQVANANISATNAELSTVLEVLQAEK 1144
Cdd:PLN02939   36 RARRRGFSSQQKKKRGKNIAPKQRS-SNSKLQSNTDENGQLENTSLR--TVMELPQKSTSSDDDHNRASMQRDEAIAAID 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1145 SETNHIFELFEMEADMNSERLIEKvtgIKEELKETHLQLDERQKKFEELEEKLKQaqqsEQKLQQESQTSKEKLTEIQQS 1224
Cdd:PLN02939  113 NEQQTNSKDGEQLSDFQLEDLVGM---IQNAEKNILLLNQARLQALEDLEKILTE----KEALQGKINILEMRLSETDAR 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1225 LQeLQDSVKQKEELVQNLEEKVRESSSIIEAQN-----------TKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQE 1293
Cdd:PLN02939  186 IK-LAAQEKIHVEILEEQLEKLRNELLIRGATEglcvhslskelDVLKEENMLLKDDIQFLKAELIEVAETEERVFKLEK 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1294 EAAKLSGELQQVQ----EANGDI-KDSLVKVE---ELVKVLEEKLQAATSQLDAQQAT---NKELQELLVKSQEN--EGN 1360
Cdd:PLN02939  265 ERSLLDASLRELEskfiVAQEDVsKLSPLQYDcwwEKVENLQDLLDRATNQVEKAALVldqNQDLRDKVDKLEASlkEAN 344

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245  1361 LQGESLAVTEKLQQ--------LEQANGELKEALCQKENGLKELQGKLdeSNTVLESQKKSHNEIQDKL 1421
Cdd:PLN02939  345 VSKFSSYKVELLQQklklleerLQASDHEIHSYIQLYQESIKEFQDTL--SKLKEESKKRSLEHPADDM 411
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1163-1302 4.93e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 4.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1163 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQ---ESQTSKEkLTEIQQSLQELQDSVKQKEELV 1239
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgNVRNNKE-YEALQKEIESLKRRISDLEDEI 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1240 QNLEEKVRESSSIIEAQNTKLNESNVQLENKTsclKETQDQLLESQKKEKQLQEEAAKLSGEL 1302
Cdd:COG1579  113 LELMERIEELEEELAELEAELAELEAELEEKK---AELDEELAELEAELEELEAEREELAAKI 172
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 793-960 5.12e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  793 KLQAALEELKKEKETI---IKEKEQELQQLQSKSAESESALKVVQvqleqlqqqaaasgeegsKTVAKLHDEISQLKSQA 869
Cdd:COG1579   14 ELDSELDRLEHRLKELpaeLAELEDELAALEARLEAAKTELEDLE------------------KEIKRLELEIEEVEARI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  870 EETQSELKSTQSN--LEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALE 947
Cdd:COG1579   76 KKYEEQLGNVRNNkeYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE 155

                        170
                 ....*....|...
gi 28574245  948 KVNKEYAESRAEA 960
Cdd:COG1579  156 AELEELEAEREEL 168
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1094-1541 5.38e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.89  E-value: 5.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1094 ELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEK--SETNHIFELFEMEADMN-SERLIEKVT 1170
Cdd:pfam10174  213 EELHRRNQLQPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNGllHTEDREEEIKQMEVYKShSKFMKNKID 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1171 GIKEEL--KETHL------------QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1236
Cdd:pfam10174  293 QLKQELskKESELlalqtkletltnQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLT 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1237 ELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI---- 1312
Cdd:pfam10174  373 EEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKerii 452

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1313 --------KDSLVKVEELvKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKE 1384
Cdd:pfam10174  453 erlkeqreREDRERLEEL-ESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKE 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1385 ALCQKENGLKELQGkldesntvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQlllE 1464
Cdd:pfam10174  532 ECSKLENQLKKAHN--------AEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKD---K 600

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245   1465 KGNEFDTQLAEYQKviDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAyletkeLRRQLESL--ELEKSREVL 1541
Cdd:pfam10174  601 KIAELESLTLRQMK--EQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNS------QQLQLEELmgALEKTRQEL 671
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 372-544 6.71e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 6.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  372 LREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQfcgDELNAQSQVYKE 451
Cdd:COG4942   32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR---AELEAQKEELAE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  452 KIHDLEskitkLVSATPSLQSILPPDLPSDDG---------------------ALQEEIAKLQEKMTIQQKEVESRIAEQ 510
Cdd:COG4942  109 LLRALY-----RLGRQPPLALLLSPEDFLDAVrrlqylkylaparreqaeelrADLAELAALRAELEAERAELEALLAEL 183

                        170       180       190
                 ....*....|....*....|....*....|....
gi 28574245  511 LEEEQRLRENVKYLNEQIATLQSELVSKDEALEK 544
Cdd:COG4942  184 EEERAALEALKAERQKLLARLEKELAELAAELAE 217
PRK11281 PRK11281
mechanosensitive channel MscK;
668-915 7.64e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 47.60  E-value: 7.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   668 KSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQ-LAEQEKLVREMTEN---------AINQIQLEKESI---EQQ 734
Cdd:PRK11281   50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQqLAQAPAKLRQAQAElealkddndEETRETLSTLSLrqlESR 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   735 LALKQNELEDFQKK-----------QSESE----------VHLQEIKAQ-NTQKDFELVESGESLKKLQQQL-------- 784
Cdd:PRK11281  130 LAQTLDQLQNAQNDlaeynsqlvslQTQPEraqaalyansQRLQQIRNLlKGGKVGGKALRPSQRVLLQAEQallnaqnd 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   785 -EQKTL-GHEKLQAALEELKKEKETIIKEKEQELQQLQskSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAK---LH 859
Cdd:PRK11281  210 lQRKSLeGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQ--EAINSKRLTLSEKTVQEAQSQDEAARIQANPLVAQeleIN 287

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   860 DEISQLKSQAEETQSELksTQSNLEAKSkQLEAANGSleEEAKKsghllEQITKLK 915
Cdd:PRK11281  288 LQLSQRLLKATEKLNTL--TQQNLRVKN-WLDRLTQS--ERNIK-----EQISVLK 333
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1077-1484 9.29e-05

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 47.14  E-value: 9.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1077 TQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQvanANISATNAELSTVLEVLQAEKSETNHIFELFE- 1155
Cdd:PRK04778  110 IESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELR---KSLLANRFSFGPALDELEKQLENLEEEFSQFVe 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1156 -------MEADMNSERLIEKVTGIKEELKETHLQLDERQKKF----EELEEKLKQAQQS-----EQKLQQESQTSKEKLT 1219
Cdd:PRK04778  187 ltesgdyVEAREILDQLEEELAALEQIMEEIPELLKELQTELpdqlQELKAGYRELVEEgyhldHLDIEKEIQDLKEQID 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1220 EIQQSLQELQdsVKQKEELVQNLEEKVRESSSIIEaqnTKLNESNVQLENKtsclKETQDQLLESQKKEKQLQEEAAKLS 1299
Cdd:PRK04778  267 ENLALLEELD--LDEAEEKNEEIQERIDQLYDILE---REVKARKYVEKNS----DTLPDFLEHAKEQNKELKEEIDRVK 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1300 -------GELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATS---QLDAQQATNKELQELLVKSQENEGNLQGESLAVT 1369
Cdd:PRK04778  338 qsytlneSELESVRQLEKQLESLEKQYDEITERIAEQEIAYSElqeELEEILKQLEEIEKEQEKLSEMLQGLRKDELEAR 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1370 EKLQQLEQANGELKEALcQKEN--GL--------KELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSK-- 1437
Cdd:PRK04778  418 EKLERYRNKLHEIKRYL-EKSNlpGLpedylemfFEVSDEIEALAEELEEKPINMEAVNRLLEEATEDVETLEEETEElv 496

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 28574245  1438 ----LAEQLSQ----LKQANEELQKSLQQKQLLLeKGNEFDTQLAEYQKVIDEMD 1484
Cdd:PRK04778  497 enatLTEQLIQyanrYRSDNEEVAEALNEAERLF-REYDYKAALEIIATALEKVE 550
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1367-1572 9.48e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.07  E-value: 9.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1367 AVTEKLQQLEQANGELKEALCQKengLKELQGKLDEsntvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLK 1446
Cdd:COG4717   50 RLEKEADELFKPQGRKPELNLKE---LKELEEELKE----AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1447 QANE------ELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYL 1520
Cdd:COG4717  123 KLLQllplyqELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE 202

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 28574245 1521 ETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKI 1572
Cdd:COG4717  203 ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLI 254
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1620-1637 9.53e-05

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 40.91  E-value: 9.53e-05
                           10
                   ....*....|....*...
gi 28574245   1620 RLFCDICDEFDqHDTEDC 1637
Cdd:pfam16641    1 RPYCEICEVFG-HDTEDC 17
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1225-1449 9.96e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1225 LQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQ 1304
Cdd:COG3883   18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYR 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1305 vQEANGDIKDSLVKVEEL------VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQA 1378
Cdd:COG3883   98 -SGGSVSYLDVLLGSESFsdfldrLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245 1379 NGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAN 1449
Cdd:COG3883  177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAA 247
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 729-1311 1.13e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 47.05  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    729 ESIEQQLALKQNELEDFQKKQSEsevhLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETI 808
Cdd:pfam07111   59 QALSQQAELISRQLQELRRLEEE----VRLLRETSLQQKMRLEAQAMELDALAVAEKAGQAEAEGLRAALAGAEMVRKNL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    809 IKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTV----AKLHDEISQLKSQAEETQSELKSTQSNLE 884
Cdd:pfam07111  135 EEGSQRELEEIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLetkrAGEAKQLAEAQKEAELLRKQLSKTQEELE 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    885 AKSKQLEAANGSLEEEAKKSGH----------LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEK------ 948
Cdd:pfam07111  215 AQVTLVESLRKYVGEQVPPEVHsqtwelerqeLLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRkiqpsd 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    949 -VNKEYAES-RAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSkfsdeiatghkELTSKADAWSQEMLQKEKELQE 1026
Cdd:pfam07111  295 sLEPEFPKKcRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVA-----------ELQEQVTSQSQEQAILQRALQD 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1027 LRQQLQDSQDSQTKLKAEGERKEKSfeesiKNLQEEVTKAKTENLELSTG----TQTTIKDLQERLEITNAELQHKEKMA 1102
Cdd:pfam07111  364 KAAEVEVERMSAKGLQMELSRAQEA-----RRRQQQQTASAEEQLKFVVNamssTQIWLETTMTRVEQAVARIPSLSNRL 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1103 SEDAQKIADLKTLVeAIQVANANISA-----------TNAELSTVLEVLQAEKSETNHIFELfemeadmnSERLIEKVTG 1171
Cdd:pfam07111  439 SYAVRKVHTIKGLM-ARKVALAQLRQescpppppappVDADLSLELEQLREERNRLDAELQL--------SAHLIQQEVG 509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1172 IKEELKEThlqlderqkkfeELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDS-----------VKQKEELVQ 1240
Cdd:pfam07111  510 RAREQGEA------------ERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESteeaaslrqelTQQQEIYGQ 577

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1241 NLEEKVRESSSIIEAQ--NTKLNESNVQLENKTSCLKETQDQLLESQKKE-----KQLQEEAAKLSGE--LQQVQEANGD 1311
Cdd:pfam07111  578 ALQEKVAEVETRLREQlsDTKRRLNEARREQAKAVVSLRQIQHRATQEKErnqelRRLQDEARKEEGQrlARRVQELERD 657
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1213-1530 1.24e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 46.84  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1213 TSKEKLTEIQQSLQELQdsvkqkeeLVQnLEEKVRESSSiieAQNTKLNESNVQLENKTSCLKetqdQLLESQKKEKQLQ 1292
Cdd:PRK05771   13 TLKSYKDEVLEALHELG--------VVH-IEDLKEELSN---ERLRKLRSLLTKLSEALDKLR----SYLPKLNPLREEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1293 EEAAKLSGElqqvqEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQ-----ELLVKSQENEGNLQGESLA 1367
Cdd:PRK05771   77 KKVSVKSLE-----ELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEpwgnfDLDLSLLLGFKYVSVFVGT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1368 VTEKLQQLEQANGELKEALCQKENGLKE------LQGKLDESNTVLESQKKSHNEIQDkleqaqqkERTLQEETSKLAEQ 1441
Cdd:PRK05771  152 VPEDKLEELKLESDVENVEYISTDKGYVyvvvvvLKELSDEVEEELKKLGFERLELEE--------EGTPSELIREIKEE 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1442 LSQLKQANEELQKSLqqkqlllekgNEFDTQLAEYQKVIDEMDDAASVKSALLEQL--------------QNRVAELETA 1507
Cdd:PRK05771  224 LEEIEKERESLLEEL----------KELAKKYLEELLALYEYLEIELERAEALSKFlktdktfaiegwvpEDRVKKLKEL 293

                         330       340
                  ....*....|....*....|...
gi 28574245  1508 LRQANDaqKTAYLETKELRRQLE 1530
Cdd:PRK05771  294 IDKATG--GSAYVEFVEPDEEEE 314
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
504-748 1.36e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  504 ESRIAEQLEEEQRLRENVKYLNEQIATLQSELvskdEALEKFSLSECGIENLRRELELLKeenekQAQEAQAEFTRKLAE 583
Cdd:COG4913  609 RAKLAALEAELAELEEELAEAEERLEALEAEL----DALQERREALQRLAEYSWDEIDVA-----SAEREIAELEAELER 679

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  584 ksveVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNvqkadssalddmlRLQKE 663
Cdd:COG4913  680 ----LDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE-------------AAEDL 742

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  664 GTEEKSTLLEKTEKELVQSKEQAAKtlndKEQLEKQISDLKQLAEQ--EKLVREMTE------NAINQIQLEKESIEQQL 735
Cdd:COG4913  743 ARLELRALLEERFAAALGDAVEREL----RENLEERIDALRARLNRaeEELERAMRAfnrewpAETADLDADLESLPEYL 818

                        250
                 ....*....|....*..
gi 28574245  736 A----LKQNELEDFQKK 748
Cdd:COG4913  819 AlldrLEEDGLPEYEER 835
mukB PRK04863
chromosome partition protein MukB;
852-1518 1.37e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   852 SKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAkskqLEAANGSLEEEAKK-SGHLLEQITKLKSevgetQAALSSCHT 930
Cdd:PRK04863  285 LEEALELRRELYTSRRQLAAEQYRLVEMARELAE----LNEAESDLEQDYQAaSDHLNLVQTALRQ-----QEKIERYQA 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   931 DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTL-----------------HAELQAERSSSSALHtkLS 993
Cdd:PRK04863  356 DLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLadyqqaldvqqtraiqyQQAVQALERAKQLCG--LP 433

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   994 KFSDEIATG-HKELTSKADAWSQEMLQKEKEL---QELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEvtKAK 1067
Cdd:PRK04863  434 DLTADNAEDwLEEFQAKEQEATEELLSLEQKLsvaQAAHSQFEQAYQLVRKIAGEVSRSEawDVARELLRRLREQ--RHL 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1068 TENLElstGTQTTIKDLQERLEitnaelQHKekmaseDAQKIADlktlvEAIQVANANIsaTNAELstvLEVLQAEKSET 1147
Cdd:PRK04863  512 AEQLQ---QLRMRLSELEQRLR------QQQ------RAERLLA-----EFCKRLGKNL--DDEDE---LEQLQEELEAR 566

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1148 nhifelfemeadmnserliekvtgiKEELKETHLQLDERQkkfEELEEKLKQAQQSEQKLQQES---QTSKEKLTEIQQS 1224
Cdd:PRK04863  567 -------------------------LESLSESVSEARERR---MALRQQLEQLQARIQRLAARApawLAAQDALARLREQ 618

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1225 LQELQDSVKQKEELVQNLEEKVREsssiieaqntkLNESNVQLENKTSCLKETQDQLLESQKKE-KQLQEEAAKLSGELQ 1303
Cdd:PRK04863  619 SGEEFEDSQDVTEYMQQLLERERE-----------LTVERDELAARKQALDEEIERLSQPGGSEdPRLNALAERFGGVLL 687

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1304 -------QVQEA---------------------------------------NGDI---KDSLVKVEEL-----VKVLEEK 1329
Cdd:PRK04863  688 seiyddvSLEDApyfsalygparhaivvpdlsdaaeqlagledcpedlyliEGDPdsfDDSVFSVEELekavvVKIADRQ 767

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1330 LQ-------------AATSQLDAQQATNKELQELLVKSQENEGNLQ----------GESLAV------------------ 1368
Cdd:PRK04863  768 WRysrfpevplfgraAREKRIEQLRAEREELAERYATLSFDVQKLQrlhqafsrfiGSHLAVafeadpeaelrqlnrrrv 847

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1369 --TEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVL-ESQKKSHNEIQDKLEQAQQKERTLQEETSKLA------ 1439
Cdd:PRK04863  848 elERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLAdETLADRVEEIREQLDEAEEAKRFVQQHGNALAqlepiv 927

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1440 -------EQLSQLKQA---NEELQKSLQQKQLLLEKGNEFDTQLAeYQKVIDEMDDAasvkSALLEQLQNRVAELETALR 1509
Cdd:PRK04863  928 svlqsdpEQFEQLKQDyqqAQQTQRDAKQQAFALTEVVQRRAHFS-YEDAAEMLAKN----SDLNEKLRQRLEQAEQERT 1002


                  ....*....
gi 28574245  1510 QANDAQKTA 1518
Cdd:PRK04863 1003 RAREQLRQA 1011
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 857-1551 1.69e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.72  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   857 KLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAkksgHLLEQITKLKSEVGETQAALSSCHTDVESKT 936
Cdd:PRK10246  202 KLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLLTAQQQQQQSL----NWLTRLDELQQEASRRQQALQQALAAEEKAQ 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   937 KQLEAAN-------------------AALEKVNKEYAESRA---EASDLQDKVKEITDTLHAELQAERSSSS---ALHTK 991
Cdd:PRK10246  278 PQLAALSlaqparqlrphweriqeqsAALAHTRQQIEEVNTrlqSTMALRARIRHHAAKQSAELQAQQQSLNtwlAEHDR 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   992 LSKFSDEIATGHKELT------SKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTK 1065
Cdd:PRK10246  358 FRQWNNELAGWRAQFSqqtsdrEQLRQWQQQLTHAEQKLNALPAITLTLTADEVAAALAQHAEQRPLRQRLVALHGQIVP 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1066 AKTENLELstgtQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAiqvananiSATNAELSTVLEVLQAEK- 1144
Cdd:PRK10246  438 QQKRLAQL----QVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTICEQ--------EARIKDLEAQRAQLQAGQp 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1145 ----SETNH--IFELFEMEADMNSERL--IEK-VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSK 1215
Cdd:PRK10246  506 cplcGSTSHpaVEAYQALEPGVNQSRLdaLEKeVKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQEEQALTQQWQAVC 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1216 EKLTEIQQSLQELQDSVKQKEELVQNLEE--KVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQL---LESQKKEKQ 1290
Cdd:PRK10246  586 ASLNITLQPQDDIQPWLDAQEEHERQLRLlsQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYaltLPQEDEEAS 665

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1291 LQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQgeslavte 1370
Cdd:PRK10246  666 WLATRQQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQCLSLHSQLQTLQ-------- 737

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1371 klQQLEQANGELKEALCQKENGLKelqgkldesNTVLESqkkshneiqdkleQAQQKERTLQEETsklAEQLSQLKQAne 1450
Cdd:PRK10246  738 --QQDVLEAQRLQKAQAQFDTALQ---------ASVFDD-------------QQAFLAALLDEET---LTQLEQLKQN-- 788

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1451 eLQKSLQQKQLLLEKGNEfdtQLAEYQKVIDE-MDDAASVksallEQLQNRVAELETALRQANDAQktayletKELRRQL 1529
Cdd:PRK10246  789 -LENQRQQAQTLVTQTAQ---ALAQHQQHRPDgLDLTVTV-----EQIQQELAQLAQQLRENTTRQ-------GEIRQQL 852

                         730       740
                  ....*....|....*....|..
gi 28574245  1530 ESlELEKSREVLSLKAQMNGAS 1551
Cdd:PRK10246  853 KQ-DADNRQQQQALMQQIAQAT 873
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 694-971 1.71e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.58  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   694 EQLEKQisdLKQLAEQEKLVREMTENAINQIQLEKESIEQQLalKQNELEDF----QKKQSESEVHLQEIKAQNTQKDFE 769
Cdd:PTZ00108 1002 GKLERE---LARLSNKVRFIKHVINGELVITNAKKKDLVKEL--KKLGYVRFkdiiKKKSEKITAEEEEGAEEDDEADDE 1076

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   770 LVESG--------------------ESLKKLQQQLEQKTLGHEKLQAA------LEELKKEKETIIKEKEQE----LQQL 819
Cdd:PTZ00108 1077 DDEEElgaavsydyllsmpiwsltkEKVEKLNAELEKKEKELEKLKNTtpkdmwLEDLDKFEEALEEQEEVEekeiAKEQ 1156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   820 QSKSAESESALKVVQ-VQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLE 898
Cdd:PTZ00108 1157 RLKSKTKGKASKLRKpKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPK 1236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245   899 EEAKKSGHLLEQITKLKSEVGETQaalSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEIT 971
Cdd:PTZ00108 1237 KSSVKRLKSKKNNSSKSSEDNDEF---SSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPT 1306
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 746-987 1.73e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.91  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  746 QKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQktlgHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 825
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  826 SESALKVVQVQLEQLQQQAAASGEegsktvaklHDEISQLKSQAEETQSE--LKSTQSNLEAKSKQLEAANGSLEEEAKK 903
Cdd:COG4942   95 LRAELEAQKEELAELLRALYRLGR---------QPPLALLLSPEDFLDAVrrLQYLKYLAPARREQAEELRADLAELAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  904 SGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERS 983
Cdd:COG4942  166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245


                 ....
gi 28574245  984 SSSA 987
Cdd:COG4942  246 AGFA 249
PRK01156 PRK01156
chromosome segregation protein; Provisional
 579-1257 1.79e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.43  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   579 RKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDeceiLQTEVRMRDEQIRELNQQLDEvttqlnvqkaDSSALDDML 658
Cdd:PRK01156  152 KKILDEILEINSLERNYDKLKDVIDMLRAEISNIDY----LEEKLKSSNLELENIKKQIAD----------DEKSHSITL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   659 RLQKEGTEEkstlLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQlAEQEKLVREMTENAINQIQLEKESIEQQLAL- 737
Cdd:PRK01156  218 KEIERLSIE----YNNAMDDYNNLKSALNELSSLEDMKNRYESEIKT-AESDLSMELEKNNYYKELEERHMKIINDPVYk 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   738 KQNELEDFQKKQSESEVHLQEIKaqntQKDFELVESGESLKKLQQQleqktlghEKLQAALEELKKEKETIikekEQELQ 817
Cdd:PRK01156  293 NRNYINDYFKYKNDIENKKQILS----NIDAEINKYHAIIKKLSVL--------QKDYNDYIKKKSRYDDL----NNQIL 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   818 QLQSKSAESESALKVVQVQLEQLqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSL 897
Cdd:PRK01156  357 ELEGYEMDYNSYLKSIESLKKKI--------EEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSL 428

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   898 EEEAKKSGHLLEQITKlKSEVGETQAALSSCHTDV-ESKTKQL-EAANAALEKVNKEYAESRAEASDLQDKVKEitdtlh 975
Cdd:PRK01156  429 NQRIRALRENLDELSR-NMEMLNGQSVCPVCGTTLgEEKSNHIiNHYNEKKSRLEEKIREIEIEVKDIDEKIVD------ 501

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   976 aelqaerssssalhtkLSKFSDEIATGHKEltskadawsqEMLQKEKELQELRQQLQDSQDSQTKLKaEGERKEKSFEES 1055
Cdd:PRK01156  502 ----------------LKKRKEYLESEEIN----------KSINEYNKIESARADLEDIKIKINELK-DKHDKYEEIKNR 554

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1056 IKNLQEEVTKAKTE--NLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEaiqvananisatnael 1133
Cdd:PRK01156  555 YKSLKLEDLDSKRTswLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID---------------- 618

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1134 STVLEVLQAEKSETNHIFELFEMEadmnseRLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQT 1213
Cdd:PRK01156  619 KSIREIENEANNLNNKYNEIQENK------ILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDD 692

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 28574245  1214 SKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQN 1257
Cdd:PRK01156  693 AKANRARLESTIEILRTRINELSDRINDINETLESMKKIKKAIG 736
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
681-884 1.79e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  681 QSKEQAAKTLndkEQLEKQISDLK-QLAEQEKLVRE-MTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQE 758
Cdd:COG3206  168 LRREEARKAL---EFLEEQLPELRkELEEAEAALEEfRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAA 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  759 IKAQNTQKDFELVESGES---------LKKLQQQLEQKTL----GHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 825
Cdd:COG3206  245 LRAQLGSGPDALPELLQSpviqqlraqLAELEAELAELSArytpNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEA 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245  826 SESALKVVQVQLEQLQQQaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLE 884
Cdd:COG3206  325 LQAREASLQAQLAQLEAR--------LAELPELEAELRRLEREVEVARELYESLLQRLE 375
PRK01156 PRK01156
chromosome segregation protein; Provisional
 780-1384 1.80e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.43  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   780 LQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvqvqleqlqqqaaasgEEGSKTVAKLH 859
Cdd:PRK01156  188 LEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNL-------------------KSALNELSSLE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   860 DEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQL 939
Cdd:PRK01156  249 DMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAII 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   940 EAAnAALEKVNKEYAESRAEASDLQDKVKEItDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQ 1019
Cdd:PRK01156  329 KKL-SVLQKDYNDYIKKKSRYDDLNNQILEL-EGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDA 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1020 KEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTT---IKDLQERLEITNAELQ 1096
Cdd:PRK01156  407 IKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSnhiINHYNEKKSRLEEKIR 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1097 HKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVlqaeksetnhifelfEMEADMNSErliekvtgikEEL 1176
Cdd:PRK01156  487 EIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARA---------------DLEDIKIKI----------NEL 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1177 KETHLQLDERQKKFEELE-EKLKQaqQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEA 1255
Cdd:PRK01156  542 KDKHDKYEEIKNRYKSLKlEDLDS--KRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDK 619

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1256 QNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSlvkvEELVKVLEEKLQAATS 1335
Cdd:PRK01156  620 SIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDI----EDNLKKSRKALDDAKA 695

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 28574245  1336 QLDAQQATNKEL----QELLVKSQENEGNLqgeslavtEKLQQLEQANGELKE 1384
Cdd:PRK01156  696 NRARLESTIEILrtriNELSDRINDINETL--------ESMKKIKKAIGDLKR 740
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 358-751 2.02e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.04  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    358 ILATPKSQFsMQDLLREKQQHVEKLMVE-------RDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQC 430
Cdd:pfam07888   23 LLVVPRAEL-LQNRLEECLQERAELLQAqeaanrqREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEE 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    431 SIDEAQFCGDELNAQSQVYKEKIHDLESKITKlvsatpslqsilppdlpsddgaLQEEIAKLQEKMTIQQKEVEsRIAEQ 510
Cdd:pfam07888  102 KYKELSASSEELSEEKDALLAQRAAHEARIRE----------------------LEEDIKTLTQRVLERETELE-RMKER 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    511 LEEEQRLRENVKYLNEQiatLQSELVSKDEALEKFSLSECGIENlrreLELLKEENEKQAQEAQAEFTRKLAEKSVEVLR 590
Cdd:pfam07888  159 AKKAGAQRKEEEAERKQ---LQAKLQQTEEELRSLSKEFQELRN----SLAQRDTQVLQLQDTITTLTQKLTTAHRKEAE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    591 LSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVtTQLNVQKADSSAldDMLRLQKEGTEEKST 670
Cdd:pfam07888  232 NEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQA-AQLTLQLADASL--ALREGRARWAQERET 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    671 LLEKTEKELVQSKEQAAKTLNDKEQLEKQISDlKQLAEQEkLVREMTENAINQIQLEKESIEQQLALK--QNELEDFQKK 748
Cdd:pfam07888  309 LQQSAEADKDRIEKLSAELQRLEERLQEERME-REKLEVE-LGREKDCNRVQLSESRRELQELKASLRvaQKEKEQLQAE 386


                   ...
gi 28574245    749 QSE 751
Cdd:pfam07888  387 KQE 389
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 756-987 2.05e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  756 LQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEketiIKEKEQELQQLQSKSAESESALKVVQV 835
Cdd:COG3883   18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEERREELGERAR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  836 QLEQLQQQAAASGE-EGSKTVAKLHDEISQLKSQAEETQS---ELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQI 911
Cdd:COG3883   94 ALYRSGGSVSYLDVlLGSESFSDFLDRLSALSKIADADADlleELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245  912 TKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSA 987
Cdd:COG3883  174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGA 249
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 920-1537 2.12e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.58  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    920 ETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITD------TLHAELQAERSSSSALHTKLS 993
Cdd:TIGR01612  541 EIEAGLKESYELAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDeiiyinKLKLELKEKIKNISDKNEYIK 620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    994 KfsdeiATGHKELTSKADAWSQEmLQKEKELQELRQQLQDSQDSQTkLKAEgerKEKSFEESIKNLQEEVTKAKTENLEL 1073
Cdd:TIGR01612  621 K-----AIDLKKIIENNNAYIDE-LAKISPYQVPEHLKNKDKIYST-IKSE---LSKIYEDDIDALYNELSSIVKENAID 690

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1074 STGTQTTIKDLQERLEITNAELQHKEKMASE------DAQKIADLKTLVEAIQVANANIsatNAELSTVLEVLQA-EKSE 1146
Cdd:TIGR01612  691 NTEDKAKLDDLKSKIDKEYDKIQNMETATVElhlsniENKKNELLDIIVEIKKHIHGEI---NKDLNKILEDFKNkEKEL 767

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1147 TNHIFELFEMEADMNSERliEKVTGIK--------------EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQE-- 1210
Cdd:TIGR01612  768 SNKINDYAKEKDELNKYK--SKISEIKnhyndqinidnikdEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDfl 845

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1211 ---------SQTSKEKLTEIQQSLQELQDSVKQK--EELVQNLEEKVRESSSIIEAQNTKLNE--SNVQLENKTS----C 1273
Cdd:TIGR01612  846 nkvdkfinfENNCKEKIDSEHEQFAELTNKIKAEisDDKLNDYEKKFNDSKSLINEINKSIEEeyQNINTLKKVDeyikI 925

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1274 LKETQDQLLESQKKEKQLQEeaaKLSGELQQVQEAN-------GDIKDSLV-KVEELVKVLEEklqaatSQLDAQQATNK 1345
Cdd:TIGR01612  926 CENTKESIEKFHNKQNILKE---ILNKNIDTIKESNlieksykDKFDNTLIdKINELDKAFKD------ASLNDYEAKNN 996

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1346 ELQELLVKSQENEGNLQGESL---------AVTEKLQQLEQANGELKE-------ALCQKENGLKELQGKLDES--NTVL 1407
Cdd:TIGR01612  997 ELIKYFNDLKANLGKNKENMLyhqfdekekATNDIEQKIEDANKNIPNieiaihtSIYNIIDEIEKEIGKNIELlnKEIL 1076

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1408 ESQKKS---HNEIQDKLEQAQQKErTLQEETSKLAEQLSQLKQ----ANEELQKSLQQKQLLLEKG----NEFDTQLAEY 1476
Cdd:TIGR01612 1077 EEAEINitnFNEIKEKLKHYNFDD-FGKEENIKYADEINKIKDdiknLDQKIDHHIKALEEIKKKSenyiDEIKAQINDL 1155

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245   1477 QKVIDEMDDAASVKSaLLEQLQNRVAELetalrqanDAQKTAYLETKELRRQLESLELEKS 1537
Cdd:TIGR01612 1156 EDVADKAISNDDPEE-IEKKIENIVTKI--------DKKKNIYDEIKKLLNEIAEIEKDKT 1207
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1198-1454 2.14e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 45.57  E-value: 2.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1198 KQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEA---QNTKLNESNVQLENKTSCL 1274
Cdd:pfam15905   55 KVKSLELKKKSQKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAavrEKTSLSASVASLEKQLLEL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1275 KETQDqLLESQKKEKQLQEEAAKLSGELQQVQ-EANGDIKDSLVKVEELvkvlEEKLQAATSQLDAQQATNKELQELLVK 1353
Cdd:pfam15905  135 TRVNE-LLKAKFSEDGTQKKMSSLSMELMKLRnKLEAKMKEVMAKQEGM----EGKLQVTQKNLEHSKGKVAQLEEKLVS 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1354 S--QENEGNLQGESL--------AVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHN-------- 1415
Cdd:pfam15905  210 TekEKIEEKSETEKLleyitelsCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNekcklles 289

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 28574245   1416 EIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQK 1454
Cdd:pfam15905  290 EKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1215-1475 2.76e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 45.45  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1215 KEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSsIIEAQNTKLNESNvqlenktscLKETQDQLLESqkkEKQLQEE 1294
Cdd:COG0497  154 EELLEEYREAYRAWRALKKELEELRADEAERARELD-LLRFQLEELEAAA---------LQPGEEEELEE---ERRRLSN 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1295 AAKLSGELQQVQEAngdIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVT---EK 1371
Cdd:COG0497  221 AEKLREALQEALEA---LSGGEGGALDLLGQALRALERLAEYDPSLAELAERLESALIELEEAASELRRYLDSLEfdpER 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1372 LQQLEQANGELKeALCQKENG--------LKELQGKLDEsntvLESqkkshneIQDKLEQAQQKERTLQEETSKLAEQLS 1443
Cdd:COG0497  298 LEEVEERLALLR-RLARKYGVtveellayAEELRAELAE----LEN-------SDERLEELEAELAEAEAELLEAAEKLS 365

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 28574245 1444 QL-KQANEELQKSLQQ--KQLLLEKGnEFDTQLAE 1475
Cdd:COG0497  366 AArKKAAKKLEKAVTAelADLGMPNA-RFEVEVTP 399
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 368-1067 2.81e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 45.73  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    368 MQDLLREKQQHVEKLMVERDldredAQNQALQLQKNINELKARIVEL---ESALDNERKKTEeLQCSIDEAQFCGDELNA 444
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKRE-----AQEEQLKKQQLLKQLRARIEELraqEAVLEETQERIN-RARKAAPLAAHIKAVTQ 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    445 QSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYL 524
Cdd:TIGR00618  305 IEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTL 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    525 NEQIATLQSELVSKDEALEKFSlsecgiENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQnlkatsds 604
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELDILQ------REQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCT-------- 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    605 leservnktdeceilQTEVRMRDEQIRELNQQLDEvttqlnvqkadssalddmlRLQKEGTEEKSTLLEKTEKELVQSKE 684
Cdd:TIGR00618  451 ---------------AQCEKLEKIHLQESAQSLKE-------------------REQQLQTKEQIHLQETRKKAVVLARL 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    685 QaaktlndkEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKesIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNT 764
Cdd:TIGR00618  497 L--------ELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQR--GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQ 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    765 QKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQA 844
Cdd:TIGR00618  567 EIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLT 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    845 AASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAA 924
Cdd:TIGR00618  647 ALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENA 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    925 LSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHK 1004
Cdd:TIGR00618  727 SSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEA 806

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245   1005 ELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAK 1067
Cdd:TIGR00618  807 EIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQA 869
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1157-1384 2.89e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.90  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1157 EADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1236
Cdd:COG1340   19 ELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1237 ELVQNLEEKVRESSSI---IEAQNTKLNESNVQLENKTSCLKETQD--QLLESQKKEKQLQEEAAKLSGELQQVQEANGD 1311
Cdd:COG1340   99 KELAELNKAGGSIDKLrkeIERLEWRQQTEVLSPEEEKELVEKIKEleKELEKAKKALEKNEKLKELRAELKELRKEAEE 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574245 1312 IKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKE 1384
Cdd:COG1340  179 IHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRK 251
COG5022 COG5022
Myosin heavy chain [General function prediction only];
578-898 3.02e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 45.84  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  578 TRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEIL---QTEVRMRDEQIRELNQQLDEVTTQLNVQKAD---- 650
Cdd:COG5022  829 EKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLLKKETIYlqsAQRVELAERQLQELKIDVKSISSLKLVNLELesei 908

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  651 ---SSALDDMLRLQKEGTEEKSTLLEKTEKElVQSKEQAAKTLNDKEQLEK---QISDLKQLAEQEKLVREMTENAINQI 724
Cdd:COG5022  909 ielKKSLSSDLIENLEFKTELIARLKKLLNN-IDLEEGPSIEYVKLPELNKlheVESKLKETSEEYEDLLKKSTILVREG 987

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  725 QLEKESIE---QQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALE 799
Cdd:COG5022  988 NKANSELKnfkKELAELSKQYGALQESTKQLKELPVEVaeLQSASKIISSESTELSILKPLQKLKGLLLLENNQLQARYK 1067

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  800 ELKKEKETIIKEKEQELQQLQSKSAESESALKvvqvqleqlqqQAAASGEEGSKTVAKLHDEISQLKSQAEETQSE--LK 877
Cdd:COG5022 1068 ALKLRRENSLLDDKQLYQLESTENLLKTINVK-----------DLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISkfLS 1136

                        330       340
                 ....*....|....*....|.
gi 28574245  878 STQSNLEAKSKQLEAANGSLE 898
Cdd:COG5022 1137 QLVNTLEPVFQKLSVLQLELD 1157
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1239-1546 3.19e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.71  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1239 VQNLEEKVRESSSIIEAQNTKLNESNVQLENKTScLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEA---------- 1308
Cdd:COG3096  274 MRHANERRELSERALELRRELFGARRQLAEEQYR-LVEMARELEELSARESDLEQDYQAASDHLNLVQTAlrqqekiery 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1309 NGDIKDSLVKVEELVKVLE---EKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQAngelkEA 1385
Cdd:COG3096  353 QEDLEELTERLEEQEEVVEeaaEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKA-----RA 427

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1386 LCQK--------ENGLKELQGKLDE-SNTVLESQKK------SHNEIQDKLE------------QAQQKERTLQE---ET 1435
Cdd:COG3096  428 LCGLpdltpenaEDYLAAFRAKEQQaTEEVLELEQKlsvadaARRQFEKAYElvckiageversQAWQTARELLRryrSQ 507

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1436 SKLAEQLSQLKQANEELQKSLQQKQlllekgnEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQ 1515
Cdd:COG3096  508 QALAQRLQQLRAQLAELEQRLRQQQ-------NAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQR 580

                        330       340       350
                 ....*....|....*....|....*....|.
gi 28574245 1516 KTAYLETKELRRQLESLElekSREVLSLKAQ 1546
Cdd:COG3096  581 SELRQQLEQLRARIKELA---ARAPAWLAAQ 608
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1381-1570 3.32e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1381 ELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEEtskLAEQLSQLKQANEELQKSLQQKQ 1460
Cdd:COG3883   20 AKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAE---IAEAEAEIEERREELGERARALY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1461 -------------------------LLLEKGNEFDTQ-LAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDA 1514
Cdd:COG3883   97 rsggsvsyldvllgsesfsdfldrlSALSKIADADADlLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245 1515 QKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLA 1570
Cdd:COG3883  177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1045-1436 3.58e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.33  E-value: 3.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1045 GERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANA 1124
Cdd:COG5185  177 KKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1125 NISATNAELSTVLEVLQAEKSE-----TNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQldeRQKKFEELEEKLKQ 1199
Cdd:COG5185  257 KLVEQNTDLRLEKLGENAESSKrlnenANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLA---AAEAEQELEESKRE 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1200 AQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNlEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKET-Q 1278
Cdd:COG5185  334 TETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKS-SEELDSFKDTIESTKESLDEIPQNQRGYAQEILATlE 412

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1279 DQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLeeklqaatSQLDAQQATNKELQELLVKSQENE 1358
Cdd:COG5185  413 DTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEE--------SQSRLEEAYDEINRSVRSKKEDLN 484

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1359 GNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTV--LESQKKSHNEIQDKLEQAQQKERTLQEETS 1436
Cdd:COG5185  485 EELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRArgYAHILALENLIPASELIQASNAKTDGQAAN 564
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
612-811 3.78e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  612 KTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKA---DSSALDDMLRLQKEgteekstlLEKTEKELvqskEQAAK 688
Cdd:COG4913  615 LEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeYSWDEIDVASAERE--------IAELEAEL----ERLDA 682

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  689 TLNDKEQLEKQISDLKQLAEQeklvremTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDF 768
Cdd:COG4913  683 SSDDLAALEEQLEELEAELEE-------LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERF 755

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 28574245  769 ELVESGESLKKLQQQLEQKTlghEKLQAALEELKKEKETIIKE 811
Cdd:COG4913  756 AAALGDAVERELRENLEERI---DALRARLNRAEEELERAMRA 795
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1428-1597 4.22e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1428 ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL---EKGNEFDTQLAEYQkVIDEMDDAASV--KSALLEQLQNRVA 1502
Cdd:COG4913  220 EPDTFEAADALVEHFDDLERAHEALEDAREQIELLEpirELAERYAAARERLA-ELEYLRAALRLwfAQRRLELLEAELE 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1503 ELETALRQANDAQKtayletkELRRQLESLEleksREVLSLKAQMNGASsrsgkGDEVESLDietslAKINFLNSIIADM 1582
Cdd:COG4913  299 ELRAELARLEAELE-------RLEARLDALR----EELDELEAQIRGNG-----GDRLEQLE-----REIERLERELEER 357

                        170
                 ....*....|....*
gi 28574245 1583 QQKNDALKAKVQTLE 1597
Cdd:COG4913  358 ERRRARLEALLAALG 372
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
578-827 4.36e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  578 TRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQT---------EVRMRDEQIRELNQQLDEVTtqlnvqk 648
Cdd:COG4913  609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLD------- 681

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  649 ADSSALDdmlRLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI---- 724
Cdd:COG4913  682 ASSDDLA---ALEEQ--------LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLElral 750

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  725 ------QLEKESIEQQLALK-QNELEDFQKKQSESEVHLQEIKAQ-NTQKDFELVESGESLKKLQQQLEQktlgHEKLQA 796
Cdd:COG4913  751 leerfaAALGDAVERELRENlEERIDALRARLNRAEEELERAMRAfNREWPAETADLDADLESLPEYLAL----LDRLEE 826

                        250       260       270
                 ....*....|....*....|....*....|...
gi 28574245  797 -ALEELKKE-KETIIKEKEQELQQLQSKSAESE 827
Cdd:COG4913  827 dGLPEYEERfKELLNENSIEFVADLLSKLRRAI 859
PRK11637 PRK11637
AmiB activator; Provisional
 1214-1450 4.47e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 44.68  E-value: 4.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1214 SKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKlnesnvqlenktscLKETQDQLLESQKKEKQLQE 1293
Cdd:PRK11637   45 NRDQLKSIQQDIAAKEKSVRQQQQQRASLLAQLKKQEEAISQASRK--------------LRETQNTLNQLNKQIDELNA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1294 EAAKLsgELQQVQeangdikdslvkveelvkvlEEKLQAAtsQLDA--QQATNKELQELLvksqENEGNLQGESL----- 1366
Cdd:PRK11637  111 SIAKL--EQQQAA--------------------QERLLAA--QLDAafRQGEHTGLQLIL----SGEESQRGERIlayfg 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1367 ----AVTEKLQQLEQANGELKEalcQKenglKELQGKLDESNTVLESQKKShneiQDKLEQAQQ-KERTLQEETSKLAE- 1440
Cdd:PRK11637  163 ylnqARQETIAELKQTREELAA---QK----AELEEKQSQQKTLLYEQQAQ----QQKLEQARNeRKKTLTGLESSLQKd 231

                         250
                  ....*....|..
gi 28574245  1441 --QLSQLKQaNE 1450
Cdd:PRK11637  232 qqQLSELRA-NE 242
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1043-1237 4.91e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1043 AEGERKEKSFEESIKNLQEEVTKAKTENLELstgtQTTIKDLQERLEITNAELQHKEKmasEDAQKIADLKTLVEAIQVA 1122
Cdd:COG3883   26 SELQAELEAAQAELDALQAELEELNEEYNEL----QAELEALQAEIDKLQAEIAEAEA---EIEERREELGERARALYRS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1123 NANISATNAelstvleVLQAEK-SETNHIFELFEMEADMNSErLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQ 1201
Cdd:COG3883   99 GGSVSYLDV-------LLGSESfSDFLDRLSALSKIADADAD-LLEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 28574245 1202 QSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEE 1237
Cdd:COG3883  171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 391-1210 5.02e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.17  E-value: 5.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    391 EDAQNQALQLQKNINELKARIVELESALDNERKK-----------TEELQCSIDEAQFCGDELNAQsqvykekiHDLESK 459
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAArnkaekqrrdlGEELEALKTELEDTLDTTAAQ--------QELRSK 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    460 ITKLVSatpSLQSILPPDLPSDDGALQEeiaklqekMTIQQKEVESRIAEQLEEEQRLRENvkyLNEQIATLQSElvSKD 539
Cdd:pfam01576  325 REQEVT---ELKKALEEETRSHEAQLQE--------MRQKHTQALEELTEQLEQAKRNKAN---LEKAKQALESE--NAE 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    540 EALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEftRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEIL 619
Cdd:pfam01576  389 LQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESE--RQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSL 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    620 QTEVRMRDEQIRELNQQLDEVTTQLnvqkadssalddmlrlqKEGTEEKSTLLEKTEKElVQSKEQAAKTLndkEQLEKQ 699
Cdd:pfam01576  467 ESQLQDTQELLQEETRQKLNLSTRL-----------------RQLEDERNSLQEQLEEE-EEAKRNVERQL---STLQAQ 525

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    700 ISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAqNTQKDFELVesgESLKK 779
Cdd:pfam01576  526 LSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLV-DLDHQRQLV---SNLEK 601

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    780 LQQQLEQkTLGHEKLQAA--------LEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGE-- 849
Cdd:pfam01576  602 KQKKFDQ-MLAEEKAISAryaeerdrAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKnv 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    850 -EGSKTVAKLHDEISQLKSQAEETQSELKSTQS-------NLEAK----------------------SKQLEAANGSLEE 899
Cdd:pfam01576  681 hELERSKRALEQQVEEMKTQLEELEDELQATEDaklrlevNMQALkaqferdlqardeqgeekrrqlVKQVRELEAELED 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    900 EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA--- 976
Cdd:pfam01576  761 ERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNlea 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    977 ---ELQAERSSSSALHTKLSKFSDEIAtghKELTSKADawSQEMLQKEKELQELRqqlqdsqdsQTKLKAEGERKEKSFE 1053
Cdd:pfam01576  841 ellQLQEDLAASERARRQAQQERDELA---DEIASGAS--GKSALQDEKRRLEAR---------IAQLEEELEEEQSNTE 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1054 ESIKNLQEEVTKAKTENLELSTGTQTTIK--DLQERLEITNAELqhKEKMASEDAQKIADLKTLVEAIQvananisATNA 1131
Cdd:pfam01576  907 LLNDRLRKSTLQVEQLTTELAAERSTSQKseSARQQLERQNKEL--KAKLQEMEGTVKSKFKSSIAALE-------AKIA 977

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1132 ELSTVLEVLQAEKSETNHIF-----ELFEMEADMNSERliEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQK 1206
Cdd:pfam01576  978 QLEEQLEQESRERQAANKLVrrtekKLKEVLLQVEDER--RHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRK 1055


                   ....
gi 28574245   1207 LQQE 1210
Cdd:pfam01576 1056 LQRE 1059
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 913-1284 5.07e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 44.84  E-value: 5.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    913 KLKSEVGETQAALsschTDVESKTKQLeaaNAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKL 992
Cdd:pfam06160   83 KAKKALDEIEELL----DDIEEDIKQI---LEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSYGPAIDELEKQL 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    993 SKFSDEIATgHKELTSKAD-AWSQEMLQK-EKELQELRQQLQDSQDSQTKLK----------AEGERK---------EKS 1051
Cdd:pfam06160  156 AEIEEEFSQ-FEELTESGDyLEAREVLEKlEEETDALEELMEDIPPLYEELKtelpdqleelKEGYREmeeegyaleHLN 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1052 FEESIKNLQEEV--TKAKTENLELsTGTQTTIKDLQERLEiTNAELQHKEKMASEDAQKiaDLKTLVEAIQVANANISAT 1129
Cdd:pfam06160  235 VDKEIQQLEEQLeeNLALLENLEL-DEAEEALEEIEERID-QLYDLLEKEVDAKKYVEK--NLPEIEDYLEHAEEQNKEL 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1130 NAELSTVLE--VLQAEKSETNHIFE--LFEMEADMNS--ERLIEKV---TGIKEELKETHLQLDERQKKFEELEEKLKQA 1200
Cdd:pfam06160  311 KEELERVQQsyTLNENELERVRGLEkqLEELEKRYDEivERLEEKEvaySELQEELEEILEQLEEIEEEQEEFKESLQSL 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1201 QQSEQKLQQESQTSKEKLTEIQQSL---------QELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENkt 1271
Cdd:pfam06160  391 RKDELEAREKLDEFKLELREIKRLVeksnlpglpESYLDYFFDVSDEIEDLADELNEVPLNMDEVNRLLDEAQDDVDT-- 468

                          410
                   ....*....|...
gi 28574245   1272 scLKETQDQLLES 1284
Cdd:pfam06160  469 --LYEKTEELIDN 479
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1163-1484 5.44e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1163 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNL 1242
Cdd:COG4372   48 EQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1243 EEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1322
Cdd:COG4372  128 EQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1323 VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE 1402
Cdd:COG4372  208 LIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEA 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1403 SNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE 1482
Cdd:COG4372  288 LEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGV 367


                 ..
gi 28574245 1483 MD 1484
Cdd:COG4372  368 AD 369
46 PHA02562
endonuclease subunit; Provisional
 1215-1462 5.81e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 5.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1215 KEKLTEIQQSLQEL---QDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQL-ENKTSCLKETQDQLLEsqkkekq 1290
Cdd:PHA02562  173 KDKIRELNQQIQTLdmkIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEaKTIKAEIEELTDELLN------- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1291 LQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEE--KLQAATSQLDaqqatnkELQELLVKSQENEGNLQGESLAV 1368
Cdd:PHA02562  246 LVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKMYEKggVCPTCTQQIS-------EGPDRITKIKDKLKELQHSLEKL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1369 TEKLQQLEQANGELKEAlcQKEngLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQA 1448
Cdd:PHA02562  319 DTAIDELEEIMDEFNEQ--SKK--LLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKT 394

                         250
                  ....*....|....
gi 28574245  1449 NEELQKSLQQKQLL 1462
Cdd:PHA02562  395 KSELVKEKYHRGIV 408
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1162-1384 5.82e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.82  E-value: 5.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1162 SERLIEKVtgiKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQElqdsvkQKEELVQN 1241
Cdd:PRK00409  500 PENIIEEA---KKLIGEDKEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQE------EEDKLLEE 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1242 LEEKVREsssIIEAqntklnesnvqlenktscLKETQDQLLesqkKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1321
Cdd:PRK00409  571 AEKEAQQ---AIKE------------------AKKEADEII----KELRQLQKGGYASVKAHELIEARKRLNKANEKKEK 625

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245  1322 LVKVLEEKlqaatsqldaqqatNKELQ--------------ELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKE 1384
Cdd:PRK00409  626 KKKKQKEK--------------QEELKvgdevkylslgqkgEVLSIPDDKEAIVQAGIMKMKVPLSDLEKIQKPKKK 688
PRK01156 PRK01156
chromosome segregation protein; Provisional
 965-1465 6.20e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.51  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   965 DKVKEITDtlhaELQAERSSSSALHTKLSKFSDEIATGHKELTSkaDAWSQEMLQKEKElqELRQQLQDSQDSQTKLKAE 1044
Cdd:PRK01156  169 DKLKDVID----MLRAEISNIDYLEEKLKSSNLELENIKKQIAD--DEKSHSITLKEIE--RLSIEYNNAMDDYNNLKSA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1045 GERKeKSFEESIKNLQEEVTKAKTEnLELSTGTQTTIKDLQERL-EITNAELQHKEKMASEDAQKIADLKTLVEAIQVAN 1123
Cdd:PRK01156  241 LNEL-SSLEDMKNRYESEIKTAESD-LSMELEKNNYYKELEERHmKIINDPVYKNRNYINDYFKYKNDIENKKQILSNID 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1124 ANISATNAELSTvLEVLQAEKSE-----------TNHIFELFEMEADMNS-----ERLIEKV-----------TGIKEEL 1176
Cdd:PRK01156  319 AEINKYHAIIKK-LSVLQKDYNDyikkksryddlNNQILELEGYEMDYNSylksiESLKKKIeeyskniermsAFISEIL 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1177 KETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQEL------------------QDSVKQKEEL 1238
Cdd:PRK01156  398 KIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLngqsvcpvcgttlgeeksNHIINHYNEK 477

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1239 VQNLEEKVREsssiIEAQNTKLNESNVQLENKTSCLK-------ETQDQLLESQKKE-KQLQEEAAKLSGELQQVQEANG 1310
Cdd:PRK01156  478 KSRLEEKIRE----IEIEVKDIDEKIVDLKKRKEYLEseeinksINEYNKIESARADlEDIKIKINELKDKHDKYEEIKN 553

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1311 DIKDslVKVEELVKVLEE--KLQAATSQLDAQ------QATNKELQELLVKSQENEGNLQGESLAVTEKLQQLE------ 1376
Cdd:PRK01156  554 RYKS--LKLEDLDSKRTSwlNALAVISLIDIEtnrsrsNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIEneannl 631

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1377 -------QANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAN 1449
Cdd:PRK01156  632 nnkyneiQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRI 711

                         570
                  ....*....|....*.
gi 28574245  1450 EELQKSLQQKQLLLEK 1465
Cdd:PRK01156  712 NELSDRINDINETLES 727
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 670-905 6.42e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 6.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  670 TLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDF---Q 746
Cdd:COG3883   16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaraL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  747 KKQSESEVHLQEIKAQNTQKDFelVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES 826
Cdd:COG3883   96 YRSGGSVSYLDVLLGSESFSDF--LDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245  827 ESALKVVQVQLEQLqqqaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSG 905
Cdd:COG3883  174 EAQQAEQEALLAQL-----------SAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 241
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 399-773 6.54e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 44.66  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   399 QLQKNINELKARIVE-LESALD--NERKKTEElqcSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsatpslqsilP 475
Cdd:PRK10929   34 QAKAAKTPAQAEIVEaLQSALNwlEERKGSLE---RAKQYQQVIDNFPKLSAELRQQLNNERDEPRSV-----------P 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   476 PDLPSDDgaLQEEIAKLQEKMTIQqkevesriAEQLEEEQ-RLRENVKYLNeQIATLQSELvskdealeKFSLSEcgIEN 554
Cdd:PRK10929  100 PNMSTDA--LEQEILQVSSQLLEK--------SRQAQQEQdRAREISDSLS-QLPQQQTEA--------RRQLNE--IER 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   555 LRRELELLKEEnekqaqEAQAEFTRKLAEKSVevlrlsselqnLKATSDSLESERVNKTDECEIlqteVRMRDE----QI 630
Cdd:PRK10929  159 RLQTLGTPNTP------LAQAQLTALQAESAA-----------LKALVDELELAQLSANNRQEL----ARLRSElakkRS 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   631 RELNQQLDEVTTQLNV--QKADSSALDDMLRLQKEGTEEKSTLLE--KTEKELVQSKEQAAKTLND-------------- 692
Cdd:PRK10929  218 QQLDAYLQALRNQLNSqrQREAERALESTELLAEQSGDLPKSIVAqfKINRELSQALNQQAQRMDLiasqqrqaasqtlq 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   693 --------KEQ-------------LEKQISDLKQLAEQEKLVREMTENAINQIQLEkESIEQQLALKQNELEDFQKKQSE 751
Cdd:PRK10929  298 vrqalntlREQsqwlgvsnalgeaLRAQVARLPEMPKPQQLDTEMAQLRVQRLRYE-DLLNKQPQLRQIRQADGQPLTAE 376

                         410       420
                  ....*....|....*....|...
gi 28574245   752 SEVHLQE-IKAQNtqkdfELVES 773
Cdd:PRK10929  377 QNRILDAqLRTQR-----ELLNS 394
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 794-1524 6.62e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 6.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    794 LQAALEELKKEKETIIKekeqELQQLQSKSAESESALKVVQVQLEQLQQQAAAsgEEGSKtvaklhdeISQLKSQAEETQ 873
Cdd:pfam10174    1 LQAQLRDLQRENELLRR----ELDIKESKLGSSMNSIKTFWSPELKKERALRK--EEAAR--------ISVLKEQYRVTQ 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    874 SELKSTQSNLEAKSKQLEAA---NGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHtdvESKTKQLEAANAALEKVN 950
Cdd:pfam10174   67 EENQHLQLTIQALQDELRAQrdlNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEH---ERQAKELFLLRKTLEEME 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    951 KEYAESRAEASDLQDKVKEITDTLHaelqaerssSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQ 1030
Cdd:pfam10174  144 LRIETQKQTLGARDESIKKLLEMLQ---------SKGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREE 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1031 ---LQDSQDSQTKLKA------EGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKM 1101
Cdd:pfam10174  215 lhrRNQLQPDPAKTKAlqtvieMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQL 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1102 ASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNhifeLFEMEADMNSERLIEKVTgikeelkethl 1181
Cdd:pfam10174  295 KQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAA----ILQTEVDALRLRLEEKES----------- 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1182 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVR---ESSSIIEAQNT 1258
Cdd:pfam10174  360 FLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKslqTDSSNTDTALT 439

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1259 KLNESNVQLENKTSCLKETQDQL-------LESQKKE-KQLQEEAAKLSGELQQ-------VQEANGDIKDSLVKVEELV 1323
Cdd:pfam10174  440 TLEEALSEKERIIERLKEQREREdrerleeLESLKKEnKDLKEKVSALQPELTEkesslidLKEHASSLASSGLKKDSKL 519

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1324 KVLEEKLQAATSQLDAQQATNKELQELLVKSQENEgnlqgeslAVTEKLQQLEQANGELKE--ALCQKE-----NGLKEL 1396
Cdd:pfam10174  520 KSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTNP--------EINDRIRLLEQEVARYKEesGKAQAEverllGILREV 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1397 QG-KLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLllekgnefDTQLAE 1475
Cdd:pfam10174  592 ENeKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQL--------EELMGA 663

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 28574245   1476 YQKVIDEMDDAASVKSALLEQLQNRVAELeTALRQANDAQKTAYLETKE 1524
Cdd:pfam10174  664 LEKTRQELDATKARLSSTQQSLAEKDGHL-TNLRAERRKQLEEILEMKQ 711
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1333-1518 7.37e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1333 ATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKK 1412
Cdd:COG3883   14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERAR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1413 S----------------HNEIQDKLEQAQQKERtLQEETSKLAEQLSQLKQANEELQKSLQQKQlllekgNEFDTQLAEY 1476
Cdd:COG3883   94 AlyrsggsvsyldvllgSESFSDFLDRLSALSK-IADADADLLEELKADKAELEAKKAELEAKL------AELEALKAEL 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 28574245 1477 QKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1518
Cdd:COG3883  167 EAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAA 208
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
484-871 7.56e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 7.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  484 ALQEEIAKLQEkmtiQQKEVESRIAEQLEEEQRLRENVKYLN--EQIATLQSELVSKDEALEKFSLSECGIENLRRELEL 561
Cdd:COG4717   92 ELQEELEELEE----ELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEELRELEEELEE 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  562 LKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVR---------MRDEQIRE 632
Cdd:COG4717  168 LEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEqleneleaaALEERLKE 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  633 LNQQLDEVTTQLNVQKADSSALDDMLRLQK--------------EGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEK 698
Cdd:COG4717  248 ARLLLLIAAALLALLGLGGSLLSLILTIAGvlflvlgllallflLLAREKASLGKEAEELQALPALEELEEEELEELLAA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  699 -QISDLKQLAEQEKLVREMTEnaINQIQLEKESIEQQLALKQNELE---DFQKKQSESEVHLQEiKAQNTQKDFELVesg 774
Cdd:COG4717  328 lGLPPDLSPEELLELLDRIEE--LQELLREAEELEEELQLEELEQEiaaLLAEAGVEDEEELRA-ALEQAEEYQELK--- 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  775 ESLKKLQQQLEQKTLGHEKLQAAL--EELKKEKETI---IKEKEQELQQLQSKSAESESALKVVqvqleqlqqqaaasge 849
Cdd:COG4717  402 EELEELEEQLEELLGELEELLEALdeEELEEELEELeeeLEELEEELEELREELAELEAELEQL---------------- 465

                        410       420
                 ....*....|....*....|..
gi 28574245  850 EGSKTVAKLHDEISQLKSQAEE 871
Cdd:COG4717  466 EEDGELAELLQELEELKAELRE 487
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1094-1566 7.78e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 7.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1094 ELQHKEKMASEDAQKIADLKTLVEAIQvananisATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIK 1173
Cdd:pfam10174   40 ELKKERALRKEEAARISVLKEQYRVTQ-------EENQHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1174 EELKETHLQLDERQKKFEELEekLKQAQQSEQKLQQESQtsKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1253
Cdd:pfam10174  113 LTEENFRRLQSEHERQAKELF--LLRKTLEEMELRIETQ--KQTLGARDESIKKLLEMLQSKGLPKKSGEEDWERTRRIA 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1254 EAQnTKLNESNVQLENKTsclKETQdQLLESQKKEKQLQEEAAKLSGeLQQVQEAN----GDIKDSLVKVEELVKVLE-- 1327
Cdd:pfam10174  189 EAE-MQLGHLEVLLDQKE---KENI-HLREELHRRNQLQPDPAKTKA-LQTVIEMKdtkiSSLERNIRDLEDEVQMLKtn 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1328 -----EKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGE-------LKEALCQKENGLKE 1395
Cdd:pfam10174  263 gllhtEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDckqhievLKESLTAKEQRAAI 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1396 LQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQkqlLLEKGNEFDTQLAE 1475
Cdd:pfam10174  343 LQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIEN---LQEQLRDKDKQLAG 419

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1476 YQKVIDE--------------MDDAASVKSALLEQLQNRVAELETALRQANDAQKTaylETKELRRQLESLE---LEKSR 1538
Cdd:pfam10174  420 LKERVKSlqtdssntdtalttLEEALSEKERIIERLKEQREREDRERLEELESLKK---ENKDLKEKVSALQpelTEKES 496

                          490       500
                   ....*....|....*....|....*....
gi 28574245   1539 EVLSLKAQMNGASSRSGKGD-EVESLDIE 1566
Cdd:pfam10174  497 SLIDLKEHASSLASSGLKKDsKLKSLEIA 525
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 630-1010 7.86e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 7.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   630 IRELNQQLDEVTTQLNVqkadsSALDDMLRLQKEGTEEKSTLLEKTEKELvqSKEQAAKTLNDKEQLEKQISDL-KQLAE 708
Cdd:NF033838   71 LSEIQKSLDKRKHTQNV-----ALNKKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKDTLEPgKKVAE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   709 QEKLVREMTENAINQIQlEKESIEQQLALKQNELE--DFQKKQSESEVHLQEIKAQNTQKDfelvesgESLKKLQQQLEQ 786
Cdd:NF033838  144 ATKKVEEAEKKAKDQKE-EDRRNYPTNTYKTLELEiaESDVEVKKAELELVKEEAKEPRDE-------EKIKQAKAKVES 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   787 KtlgheklQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLK 866
Cdd:NF033838  216 K-------KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   867 SQAEET--QSELKSTQSNLEAKSKQLEAangslEEEAKksghlleqitKLKSEVGETQAALSSCHTDVESKTKQLEAANA 944
Cdd:NF033838  289 SVGEETlpSPSLKPEKKVAEAEKKVEEA-----KKKAK----------DQKEEDRRNYPTNTYKTLELEIAESDVKVKEA 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28574245   945 ALEKVNKEYAESRAEasdlqDKVKEItdtlhaelQAERSSSSALHTKLSKFSDEIATGHKELTSKA 1010
Cdd:NF033838  354 ELELVKEEAKEPRNE-----EKIKQA--------KAKVESKKAEATRLEKIKTDRKKAEEEAKRKA 406
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
667-827 8.69e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 43.78  E-value: 8.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  667 EKSTLLEKTEKELVQSKEQAAKTLNDK-EQLEKQISDLKQ-----LAEQEKLVREMTENAINQIQLEKESIEQQLALKQN 740
Cdd:COG4487   37 ERLADAAKREAALELAEAKAKAQLQEQvAEKDAEIAELRArleaeERKKALAVAEEKEKELAALQEALAEKDAKLAELQA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  741 ELEDFQKKQSESEVHLQEIKAQnTQKdfELVESGESLK-KLQQQLEQKTLGHEKLQAA-----LEELKKEKETIIKEKEQ 814
Cdd:COG4487  117 KELELLKKERELEDAKREAELT-VEK--ERDEELDELKeKLKKEEEEKQLAEKSLKVAeyekqLKDMQEQIEELKRKKEQ 193

                        170
                 ....*....|...
gi 28574245  815 ELQQLQSKSAESE 827
Cdd:COG4487  194 GSTQLQGEVLELE 206
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
 1196-1344 8.90e-04

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 42.79  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1196 KLKQAQQSEQKLQQESQTSKEKLteiQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLK 1275
Cdd:cd21116   74 YYPDLIELADNLIKGDQGAKQQL---LQGLEALQSQVTKKQTSVTSFINELTTFKNDLDDDSRNLQTDATKAQAQVAVLN 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245 1276 ETQDQLlesqkkeKQLQEEAAKLSGELQQVQEANGDIKDSLvkveelvKVLEEKLQAATSQLDAQQATN 1344
Cdd:cd21116  151 ALKNQL-------NSLAEQIDAAIDALEKLSNDWQTLDSDI-------KELITDLEDAESSIDAAFLQA 205
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
628-1229 1.14e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  628 EQIRELNQQLDEVTTQLNVQKAdssaLDDMLRLQKEgtEEKSTLLEKtekELVQSKEQAAKTLNDKEQLEKQISDLKQLA 707
Cdd:COG4913  255 EPIRELAERYAAARERLAELEY----LRAALRLWFA--QRRLELLEA---ELEELRAELARLEAELERLEARLDALREEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  708 EQeklvremTENAINQIQLE-KESIEQQLALKQNELEDFQKKQSESEVHLQEIkaqntqkDFELVESGESLKKLQQQLEQ 786
Cdd:COG4913  326 DE-------LEAQIRGNGGDrLEQLEREIERLERELEERERRRARLEALLAAL-------GLPLPASAEEFAALRAEAAA 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  787 KTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvqvqleqlqqqaaasgeeGSKTVAKLHDEISQLK 866
Cdd:COG4913  392 LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERR---------------------KSNIPARLLALRDALA 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  867 SQAEETQSELK------------------------STQSNLEAKSKQLEAANGSLE----------EEAKKSGHLLEQIT 912
Cdd:COG4913  451 EALGLDEAELPfvgelievrpeeerwrgaiervlgGFALTLLVPPEHYAAALRWVNrlhlrgrlvyERVRTGLPDPERPR 530

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  913 --------KLKSEVGETQAALSS---------CHTDVE--------------------------------------SKTK 937
Cdd:COG4913  531 ldpdslagKLDFKPHPFRAWLEAelgrrfdyvCVDSPEelrrhpraitragqvkgngtrhekddrrrirsryvlgfDNRA 610

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  938 QLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSS-----ALHTKLSKFSDEIAtghkeltsKADA 1012
Cdd:COG4913  611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDeidvaSAEREIAELEAELE--------RLDA 682

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1013 WSQEMLQKEKELQELRQQLQDSQDSQTKLKaegeRKEKSFEESIKNLQEEVTKAKTENLEL-STGTQTTIKDLQERLEIT 1091
Cdd:COG4913  683 SSDDLAALEEQLEELEAELEELEEELDELK----GEIGRLEKELEQAEEELDELQDRLEAAeDLARLELRALLEERFAAA 758

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1092 NAELQHKEKMASedaqkiadlktLVEAIQVANANISATNAELSTVLEVLQAEksetnHIFELFEMEADMNSerlIEKVTG 1171
Cdd:COG4913  759 LGDAVERELREN-----------LEERIDALRARLNRAEEELERAMRAFNRE-----WPAETADLDADLES---LPEYLA 819

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1172 IKEELKETHLQldERQKKFEELEEKLKQAQQSE--QKLQQESQTSKEKLTEIQQSLQELQ 1229
Cdd:COG4913  820 LLDRLEEDGLP--EYEERFKELLNENSIEFVADllSKLRRAIREIKERIDPLNDSLKRIP 877
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1220-1447 1.24e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.08  E-value: 1.24e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    1220 EIQQ-SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQlLESQK-----KEKQLQE 1293
Cdd:smart00787   66 ELYQfSCKELKKYISEGRDLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQFQLVKTFAR-LEAKKmwyewRMKLLEG 144

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    1294 EAAKLSGELQQVQEAngdiKDSLVKVEELVKVLEEKLQaatsqlDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQ 1373
Cdd:smart00787  145 LKEGLDENLEGLKED----YKLLMKELELLNSIKPKLR------DRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLK 214

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574245    1374 QLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTlqeETSKLAEQLSQLKQ 1447
Cdd:smart00787  215 KLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFK---EIEKLKEQLKLLQS 285
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 664-821 1.33e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.48  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    664 GTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQeklvremTENAINQIQLEKESIEQQLALK----- 738
Cdd:pfam05667  322 KVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQ-------VEEELEELKEQNEELEKQYKVKkktld 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    739 -----QNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKL--------QQQLEQKTLGHEKLQAALEELKKek 805
Cdd:pfam05667  395 llpdaEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAksnkedesQRKLEEIKELREKIKEVAEEAKQ-- 472

                          170
                   ....*....|....*.
gi 28574245    806 etiikeKEQELQQLQS 821
Cdd:pfam05667  473 ------KEELYKQLVA 482
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 372-679 1.35e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    372 LREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKE 451
Cdd:TIGR04523  396 LESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSR 475

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    452 KI----HDLESKITKLVSATPSLQSilppdlpsddgaLQEEIAKLQEKmtiqQKEVESRIAEQLEEEQRLRENVKYLNEQ 527
Cdd:TIGR04523  476 SInkikQNLEQKQKELKSKEKELKK------------LNEEKKELEEK----VKDLTKKISSLKEKIEKLESEKKEKESK 539

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    528 IATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAqeAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLES 607
Cdd:TIGR04523  540 ISDLEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKK--KQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEK 617

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28574245    608 ERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKEL 679
Cdd:TIGR04523  618 ELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKEL 689
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-118 1.47e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245     2 SDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPqpskmkAPSSFGSTGSVSKIGRPCCNHTTP 81
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST------SSSSESSRGAAVSPGPSPSRSPSP 353

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 28574245    82 KSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTA 118
Cdd:PHA03307  354 SRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRA 390
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1180-1283 1.54e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.53  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1180 HLQLDERQKKFEELEEKLKQAQQSEQKLQQESQT-SKEKLTEIQQSLQELQ---DSVKQKEELVQNLEEKVRESSSIIEA 1255
Cdd:COG0542  403 RMEIDSKPEELDELERRLEQLEIEKEALKKEQDEaSFERLAELRDELAELEeelEALKARWEAEKELIEEIQELKEELEQ 482

                         90       100
                 ....*....|....*....|....*...
gi 28574245 1256 QNTKLNESNVQLENKTSCLKETQDQLLE 1283
Cdd:COG0542  483 RYGKIPELEKELAELEEELAELAPLLRE 510
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 597-1503 1.54e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 43.67  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   597 NLKATSDSLESERVNKtdecEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEkstllEKTE 676
Cdd:PTZ00440  881 IIKTLNIAINRSNSNK----QLVEHLLNNKIDLKNKLEQHMKIINTDNIIQKNEKLNLLNNLNKEKEKIEK-----QLSD 951

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   677 KELVQSKEQAAKTLNDKEQLEKQISDlKQLAEQEKLVREMTENAINQIQLEKESIEQQLAlkQNELEDFQKKQSESEVHL 756
Cdd:PTZ00440  952 TKINNLKMQIEKTLEYYDKSKENING-NDGTHLEKLDKEKDEWEHFKSEIDKLNVNYNIL--NKKIDDLIKKQHDDIIEL 1028

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   757 ---------QEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETI---IKEKEQELQQLQSKSA 824
Cdd:PTZ00440 1029 idklikekgKEIEEKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALlkkIDENKNKLIEIKNKSH 1108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   825 ESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEisqLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKS 904
Cdd:PTZ00440 1109 EHVVNADKEKNKQTEHYNKKKKSLEKIYKQMEKTLKE---LENMNLEDITLNEVNEIEIEYERILIDHIVEQINNEAKKS 1185

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   905 GHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAAL---EKVNKEYAESR-----AEASDLQDKVKEITDTLHA 976
Cdd:PTZ00440 1186 KTIMEEIESYKKDIDQVKKNMSKERNDHLTTFEYNAYYDKATasyENIEELTTEAKglkgeANRSTNVDELKEIKLQVFS 1265

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   977 ELQAERSSSSALHTKLSkfsdEIATGHKELTS-KADAWSQEMLQKEKELQELrqqlqdsqdsqtKLKAEGERKEKSfeES 1055
Cdd:PTZ00440 1266 YLQQVIKENNKMENALH----EIKNMYEFLISiDSEKILKEILNSTKKAEEF------------SNDAKKELEKTD--NL 1327

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1056 IKNLQEEVTKAKTENLELSTgtqtTIKDLQERLEITNAELQHKEKMASEDA-----QKIADLKTLVEaIQVANANISATN 1130
Cdd:PTZ00440 1328 IKQVEAKIEQAKEHKNKIYG----SLEDKQIDDEIKKIEQIKEEISNKRKEinkylSNIKSNKEKCD-LHVRNASRGKDK 1402

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1131 AELSTVLEVLQAEKSETNHIFELFEMeadmnserlIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQE 1210
Cdd:PTZ00440 1403 IDFLNKHEAIEPSNSKEVNIIKITDN---------INKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSILGKK 1473

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1211 SQTSKEK------LTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLES 1284
Cdd:PTZ00440 1474 TKLEKKKkeatniMDDINGEHSIIKTKLTKSSEKLNQLNEQPNIKREGDVLNNDKSTIAYETIQYNLGRVKHNLLNILNI 1553

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1285 QKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVK------VEELVKVLEEK--LQAATSQLDAQQATNKELQELLVKSQE 1356
Cdd:PTZ00440 1554 KDEIETILNKAQDLMRDISKISKIVENKNLENLNdkeadyVKYLDNILKEKqlMEAEYKKLNEIYSDVDNIEKELKKHKK 1633

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1357 N--EGNLQgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLD----ESNTVLESQKKSHNEIQDKLEQAQQKERT 1430
Cdd:PTZ00440 1634 NyeIGLLE----KVIEINKNIKLYMDSTKESLNSLVNNFSSLFNNFYlnkyNINENLEKYKKKLNEIYNEFMESYNIIQE 1709

                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574245  1431 LQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEF--DTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAE 1503
Cdd:PTZ00440 1710 KMKEVSNDDVDYNEAKTLREEAQKEEVNLNNKEEEAKKYlnDIKKQESFRFILYMKEKLDELSKMCKQQYNIVDE 1784
Rabaptin pfam03528
Rabaptin;
1187-1539 1.54e-03

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 43.17  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1187 QKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSlqelqdsvkqKEELVQNLEEKVRESSSIIEAQNTKLNESNVQ 1266
Cdd:pfam03528    7 QQRVAELEKENAEFYRLKQQLEAEFNQKRAKFKELYLA----------KEEDLKRQNAVLQEAQVELDALQNQLALARAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1267 LENKTSCLKETQDQLLES-QKKEKQLQEEAAKLSGELqqvqeangdiKDSLVKVEELVKVLEEKLQAATSQL-DAQQATN 1344
Cdd:pfam03528   77 MENIKAVATVSENTKQEAiDEVKSQWQEEVASLQAIM----------KETVREYEVQFHRRLEQERAQWNQYrESAEREI 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1345 KELQELLVKSQENEgNLQGESLAVTEKLQQL-------EQANGELKEALCQKENGLKELQG-KLDESNTVLESQKKSHNE 1416
Cdd:pfam03528  147 ADLRRRLSEGQEEE-NLEDEMKKAQEDAEKLrsvvmpmEKEIAALKAKLTEAEDKIKELEAsKMKELNHYLEAEKSCRTD 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1417 iqdkleqaqqkertLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAE-YQKVIDEMDDAASVksaLLE 1495
Cdd:pfam03528  226 --------------LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHtWQKANDQFLESQRL---LMR 288

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 28574245   1496 QLQNRVAELET-ALRQANDAQKTAYLETKELRRQLESLELEKSRE 1539
Cdd:pfam03528  289 DMQRMESVLTSeQLRQVEEIKKKDQEEHKRARTHKEKETLKSDRE 333
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1371-1518 1.57e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1371 KLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQE--ETSKLAEQLSQLKQA 1448
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlGNVRNNKEYEALQKE 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245 1449 NEELQKSLQQ-KQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1518
Cdd:COG1579   98 IESLKRRISDlEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1078-1308 1.67e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1078 QTTIKDLQERLEITNA------ELqhkeKMASEDAQKIAD-LKTLVEA-----IQVANANISATNAELSTVLEVLQAEKS 1145
Cdd:COG3206  117 EAAIERLRKNLTVEPVkgsnviEI----SYTSPDPELAAAvANALAEAyleqnLELRREEARKALEFLEEQLPELRKELE 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1146 ETNHIFELFE-----MEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLK--------------------QA 1200
Cdd:COG3206  193 EAEAALEEFRqknglVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGsgpdalpellqspviqqlraQL 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1201 QQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQ 1280
Cdd:COG3206  273 AELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAE 352

                        250       260
                 ....*....|....*....|....*...
gi 28574245 1281 LLESQKKEKQLQEEAAKLSGELQQVQEA 1308
Cdd:COG3206  353 LRRLEREVEVARELYESLLQRLEEARLA 380
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1289-1597 1.98e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.02  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1289 KQLQEEAAKLSGELQQVQEANGDIKDSLVkveELVKVLEEkLQAATSQLDAQ-QATNKELqellvksqenegNLQGESLA 1367
Cdd:COG3096  281 RELSERALELRRELFGARRQLAEEQYRLV---EMARELEE-LSARESDLEQDyQAASDHL------------NLVQTALR 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1368 VTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEEtsklAEQLSQLKQ 1447
Cdd:COG3096  345 QQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTR----AIQYQQAVQ 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1448 ANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE-----------MDDAASVKSALLEQLQNRVAELETA--------- 1507
Cdd:COG3096  421 ALEKARALCGLPDLTPENAEDYLAAFRAKEQQATEevleleqklsvADAARRQFEKAYELVCKIAGEVERSqawqtarel 500

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1508 LRQANDAQKTAYLETkELRRQLESLE--LEKSREVLSLKAQMNGASSRS-GKGDEVESL------DIETSLAKINFLNSI 1578
Cdd:COG3096  501 LRRYRSQQALAQRLQ-QLRAQLAELEqrLRQQQNAERLLEEFCQRIGQQlDAAEELEELlaeleaQLEELEEQAAEAVEQ 579

                        330
                 ....*....|....*....
gi 28574245 1579 IADMQQKNDALKAKVQTLE 1597
Cdd:COG3096  580 RSELRQQLEQLRARIKELA 598
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1111-1256 2.08e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.31  E-value: 2.08e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    1111 DLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNH-IFELFEMEADMNSERLIEkVTGIKEELKETHLQLDERQKK 1189
Cdd:smart00787  148 GLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEeLRQLKQLEDELEDCDPTE-LDRAKEKLKKLLQEIMIKVKK 226

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28574245    1190 FEELEEKLkqaqqseQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQ 1256
Cdd:smart00787  227 LEELEEEL-------QELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1157-1330 2.35e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1157 EADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEiqqsLQELQDSVKQKE 1236
Cdd:COG1579   14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQLGNVRNNK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1237 ELvQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQvqeangDIKDSL 1316
Cdd:COG1579   90 EY-EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEA------ELEELE 162

                        170
                 ....*....|....
gi 28574245 1317 VKVEELVKVLEEKL 1330
Cdd:COG1579  163 AEREELAAKIPPEL 176
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
579-820 2.56e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  579 RKLAEKSVEVLRL--------SSELQNLKATSDSLESERVNKTDeceILQTEVRMRD-EQIRELNQQLDE--VTTQLNVQ 647
Cdd:COG3206   93 RPVLERVVDKLNLdedplgeeASREAAIERLRKNLTVEPVKGSN---VIEISYTSPDpELAAAVANALAEayLEQNLELR 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  648 KADSSALDDMLRLQKEGTEEKstlLEKTEKELV--QSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI- 724
Cdd:COG3206  170 REEARKALEFLEEQLPELRKE---LEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALr 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  725 -QLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLG--------HEKLQ 795
Cdd:COG3206  247 aQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRilasleaeLEALQ 326

                        250       260       270
                 ....*....|....*....|....*....|.
gi 28574245  796 AALEELKKEKETI------IKEKEQELQQLQ 820
Cdd:COG3206  327 AREASLQAQLAQLearlaeLPELEAELRRLE 357
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 623-827 2.79e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.22  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   623 VRMRDEQIRELNQQLDEVTTQLnvQKADSSALDDMLR-LQKEGTEEKSTLLEKTEKELVQ-----SKEQAAKTLN---DK 693
Cdd:PRK05771    4 VRMKKVLIVTLKSYKDEVLEAL--HELGVVHIEDLKEeLSNERLRKLRSLLTKLSEALDKlrsylPKLNPLREEKkkvSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   694 EQLEKQISDLKQLAEQ-EKLVREMTENaINQIQLEKESIEQQLA--------------LKQNEL----------EDFQKK 748
Cdd:PRK05771   82 KSLEELIKDVEEELEKiEKEIKELEEE-ISELENEIKELEQEIErlepwgnfdldlslLLGFKYvsvfvgtvpeDKLEEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   749 QSESEVHLQEIKAQNTQKDFELV--------ESGESLKKLQQQlEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQ 820
Cdd:PRK05771  161 KLESDVENVEYISTDKGYVYVVVvvlkelsdEVEEELKKLGFE-RLELEEEGTPSELIREIKEELEEIEKERESLLEELK 239


                  ....*..
gi 28574245   821 SKSAESE 827
Cdd:PRK05771  240 ELAKKYL 246
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 723-1054 3.05e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.19  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    723 QIQLEKESIEQQLALKQNEL--EDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEE 800
Cdd:pfam07888   33 QNRLEECLQERAELLQAQEAanRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    801 LKKEKETIIKEKEQELQQLQsksaESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEisqlKSQAEETQSELKSTQ 880
Cdd:pfam07888  113 LSEEKDALLAQRAAHEARIR----ELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEE----EAERKQLQAKLQQTE 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    881 SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQ---AALSSCHTDVESKTKQLEAANAALEKVNKEYAEsr 957
Cdd:pfam07888  185 EELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHrkeAENEALLEELRSLQERLNASERKVEGLGEELSS-- 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    958 aeasdlqdkVKEITDTLHAELQAERSSSSALHTKLSKFSDeiatghkeltskadAWSQEMLQKEKELQELRQQLQDSQDS 1037
Cdd:pfam07888  263 ---------MAAQRDRTQAELHQARLQAAQLTLQLADASL--------------ALREGRARWAQERETLQQSAEADKDR 319

                          330
                   ....*....|....*..
gi 28574245   1038 QTKLKAEGERKEKSFEE 1054
Cdd:pfam07888  320 IEKLSAELQRLEERLQE 336
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 408-736 3.12e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.22  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   408 KARIVelesALDNERKKT-EELQcSIDEAQFCgdELNAQSQVykEKIHDLESKITKLVSATPSLQSILPPDlpsddGALQ 486
Cdd:PRK05771    8 KVLIV----TLKSYKDEVlEALH-ELGVVHIE--DLKEELSN--ERLRKLRSLLTKLSEALDKLRSYLPKL-----NPLR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   487 EEIAKLQEKMTIQQKEVESRIAEQLEEEqrlrenVKYLNEQIATLQSELvskdEALEKfslsecgienlrrelellkeen 566
Cdd:PRK05771   74 EEKKKVSVKSLEELIKDVEEELEKIEKE------IKELEEEISELENEI----KELEQ---------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   567 ekqaqeaqaeftrklAEKSVEVLR-LSSELQNLKATSD-SLESERVNKTDECEILQTEVrmrDEQIRELNQQLDEVTTQL 644
Cdd:PRK05771  122 ---------------EIERLEPWGnFDLDLSLLLGFKYvSVFVGTVPEDKLEELKLESD---VENVEYISTDKGYVYVVV 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   645 NVQKADSSALDDMLRlqKEGTEEKSTLLEKTEKELVQSKEQAAKTLND-KEQLEKQISDLKQLAEQEKLVREmtenAINQ 723
Cdd:PRK05771  184 VVLKELSDEVEEELK--KLGFERLELEEEGTPSELIREIKEELEEIEKeRESLLEELKELAKKYLEELLALY----EYLE 257

                         330
                  ....*....|...
gi 28574245   724 IQLEKESIEQQLA 736
Cdd:PRK05771  258 IELERAEALSKFL 270
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 581-976 4.02e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 41.97  E-value: 4.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    581 LAEKSVEVLRLSselqnlkatsDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSsalddMLRL 660
Cdd:pfam13166   87 LGEESIEIQEKI----------AKLKKEIKDHEEKLDAAEANLQKLDKEKEKLEADFLDECWKKIKRKKNS-----ALSE 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    661 QKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDkeqlEKQISDLKQLAEQEK-LVREMTENAINQIQLEKESI-EQQLALK 738
Cdd:pfam13166  152 ALNGFKYEANFKSRLLREIEKDNFNAGVLLSD----EDRKAALATVFSDNKpEIAPLTFNVIDFDALEKAEIlIQKVIGK 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    739 QNELEDFQKKQSESEvhlqeikaqntqkdfeLVESGESL-KKLQQQLE--QKTLGHEkLQAALEE------------LKK 803
Cdd:pfam13166  228 SSAIEELIKNPDLAD----------------WVEQGLELhKAHLDTCPfcGQPLPAE-RKAALEAhfddeftefqnrLQK 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    804 EKETIIKEKEQELQQLQSKSAESesalkvvqvqleqlqqqaaasgeegsKTVAKLHDEISQLKSQAEETQSELKSTQSNL 883
Cdd:pfam13166  291 LIEKVESAISSLLAQLPAVSDLA--------------------------SLLSAFELDVEDIESEAEVLNSQLDGLRRAL 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    884 EAKSKQ-------------LEAANGS-----------------LEEEAKKSGHLLEQ--ITKLKSEVGETQAALSSCHTD 931
Cdd:pfam13166  345 EAKRKDpfksieldsvdakIESINDLvasineliakhneitdnFEEEKNKAKKKLRLhlVEEFKSEIDEYKDKYAGLEKA 424

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 28574245    932 VESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA 976
Cdd:pfam13166  425 INSLEKEIKNLEAEIKKLREEIKELEAQLRDHKPGADEINKLLKA 469
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 1280-1459 4.03e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.27  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1280 QLLESQKKE-KQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQaatsQLDAQQATNKELQELLVKSQENE 1358
Cdd:pfam13851   26 ELIKSLKEEiAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLE----NYEKDKQSLKNLKARLKVLEKEL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1359 GNLQGESLAVTEKLQQLEQANGELKEalcQKENGLKELQGKLDESNTVLESQkkshneIQDKLEQAQQKERTLQEETSKL 1438
Cdd:pfam13851  102 KDLKWEHEVLEQRFEKVERERDELYD---KFEAAIQDVQQKTGLKNLLLEKK------LQALGETLEKKEAQLNEVLAAA 172

                          170       180
                   ....*....|....*....|.
gi 28574245   1439 AEQLSQLKQANEELQKSLQQK 1459
Cdd:pfam13851  173 NLDPDALQAVTEKLEDVLESK 193
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 853-994 4.08e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  853 KTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHL--LEQITKLKSEVGETQAALSSCHT 930
Cdd:COG1579   31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnNKEYEALQKEIESLKRRISDLED 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574245  931 DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSK 994
Cdd:COG1579  111 EILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPP 174
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1346-1460 4.53e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.74  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1346 ELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDES-NTVLESQKKSHNEIQDKLEQA 1424
Cdd:PRK00409  517 KLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEaQQAIKEAKKEADEIIKELRQL 596

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 28574245  1425 QQKERTLQEEtSKLAEQLSQLKQANEELQKSLQQKQ 1460
Cdd:PRK00409  597 QKGGYASVKA-HELIEARKRLNKANEKKEKKKKKQK 631
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 393-669 4.64e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 4.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  393 AQNQALQLQKNINELKARIVELESALDNERKKTEELQcsideaqfcgdelnaqsqvykEKIHDLESKItklvsatpslqs 472
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALL---------------------KQLAALERRI------------ 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  473 ilppdlpsddGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQselVSKDEALEKFSLSecgi 552
Cdd:COG4942   65 ----------AALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALY---RLGRQPPLALLLS---- 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  553 eNLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDEceiLQTEVRMRDEQIRE 632
Cdd:COG4942  128 -PEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLAR 203

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 28574245  633 LNQQLDEVTTQLNVQKADSSALDDML-RLQKEGTEEKS 669
Cdd:COG4942  204 LEKELAELAAELAELQQEAEELEALIaRLEAEAAAAAE 241
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1042-1240 4.76e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1042 KAEGERKEKSFEESIKNLQEEVTKA-------KTENLELSTGTQTT-----IKDLQERLEITNAELQHKEKMASEDAQKI 1109
Cdd:COG3206  170 REEARKALEFLEEQLPELRKELEEAeaaleefRQKNGLVDLSEEAKlllqqLSELESQLAEARAELAEAEARLAALRAQL 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1110 ADLKTLVEAIQvANANISATNAELSTvLEVLQAEKSET---NH--IFELFEMEADMNS---ERLIEKVTGIKEELKETHL 1181
Cdd:COG3206  250 GSGPDALPELL-QSPVIQQLRAQLAE-LEAELAELSARytpNHpdVIALRAQIAALRAqlqQEAQRILASLEAELEALQA 327

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28574245 1182 QLDERQKKFEELEEKLKQAQQSEQK---LQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQ 1240
Cdd:COG3206  328 REASLQAQLAQLEARLAELPELEAElrrLEREVEVARELYESLLQRLEEARLAEALTVGNVR 389
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 398-822 4.91e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.60  E-value: 4.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    398 LQLQKNINELKARIVELESALDNERKKTEELQcsideaqfcgdelnaqsqvykEKIHDLESKITKLVSATPSLQsilppd 477
Cdd:pfam05622   62 LLLQKQLEQLQEENFRLETARDDYRIKCEELE---------------------KEVLELQHRNEELTSLAEEAQ------ 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    478 lpsddgALQEEIAKLQE---KMTIQQKEVESrIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIEN 554
Cdd:pfam05622  115 ------ALKDEMDILREssdKVKKLEATVET-YKKKLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLET 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    555 lrrelellkeeNEKQAQEAQAeftrKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILqtevRMRDEQIRELN 634
Cdd:pfam05622  188 -----------YKRQVQELHG----KLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIERDTL----RETNEELRCAQ 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    635 QQLDEVTTQLNVQKADSSALDDMLR-LQKEGTEEKSTLLEKTEKELvqskeqaakTLNDKEQLEKQISDLKQLAEQeklv 713
Cdd:pfam05622  249 LQQAELSQADALLSPSSDPGDNLAAeIMPAEIREKLIRLQHENKML---------RLGQEGSYRERLTELQQLLED---- 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    714 remTENAINQIQLEKESIEQQLALKQNELEDFQKKQSEsevhlQEIKAQNT-QKDFELVESGESLKKLQQQLEQKTLGHE 792
Cdd:pfam05622  316 ---ANRRKNELETQNRLANQRILELQQQVEELQKALQE-----QGSKAEDSsLLKQKLEEHLEKLHEAQSELQKKKEQIE 387

                          410       420       430
                   ....*....|....*....|....*....|....
gi 28574245    793 KLQAALEELKKEK----ETIIKEKEQELQQLQSK 822
Cdd:pfam05622  388 ELEPKQDSNLAQKidelQEALRKKDEDMKAMEER 421
COG5391 COG5391
Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function ...
 1149-1304 5.07e-03

Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only];


Pssm-ID: 227680 [Multi-domain]  Cd Length: 524  Bit Score: 41.32  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1149 HIFELFEMEAdMNSERLIEKVTGIKEELKETHLQ-LDERQ---KKFEELEEKLkqAQQSEQKLQQESQTSKEKLTEIQ-- 1222
Cdd:COG5391  301 SIFSLFEKIL-IQLESEEESLTRLLESLNNLLLLvLNFSGvfaKRLEQNQNSI--LNEGVVQAETLRSSLKELLTQLQde 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1223 -QSLQELQDSVKQKEELVQNLEEKVRESSSIiEAQNTKLNESNV-QLENKTSCLKETQD-----QLLESQKKEKQLQEEA 1295
Cdd:COG5391  378 iKSRESLILTDSNLEKLTDQNLEDVEELSRS-LRKNSSQRAVVSqQPEGLTSFSKLSYKlrdfvQEKSRSKSIESLQQDK 456


                 ....*....
gi 28574245 1296 AKLSGELQQ 1304
Cdd:COG5391  457 EKLEEQLAI 465
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 364-817 5.44e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.63  E-value: 5.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    364 SQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELN 443
Cdd:pfam05483  209 ARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELI 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    444 AQSQVYKEKIHDLESKITKLVSATPSLQSILPP------DLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLE----E 513
Cdd:pfam05483  289 EKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIatkticQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEEllrtE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    514 EQRLRENvkylNEQIATLQSELVSKDEALEKFSlsecGIENLRRELELLKEENEKQAQeaqaeftrKLAEKSVEVLRLSS 593
Cdd:pfam05483  369 QQRLEKN----EDQLKIITMELQKKSSELEEMT----KFKNNKEVELEELKKILAEDE--------KLLDEKKQFEKIAE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    594 ELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQireLNQQLDEVTTQLNVQKADSSALD---DMLRLQ-KEGTEEKS 669
Cdd:pfam05483  433 ELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEH---YLKEVEDLKTELEKEKLKNIELTahcDKLLLEnKELTQEAS 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    670 TL---LEKTEKELVQSKEQAAKTL-----------NDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQL 735
Cdd:pfam05483  510 DMtleLKKHQEDIINCKKQEERMLkqienleekemNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQM 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245    736 ALKQNELEDFQKKQSESEVHLQEIKAQNtqKDFELVESGESlkklqQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQE 815
Cdd:pfam05483  590 KILENKCNNLKKQIENKNKNIEELHQEN--KALKKKGSAEN-----KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKE 662


                   ..
gi 28574245    816 LQ 817
Cdd:pfam05483  663 IE 664
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1167-1414 5.61e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.57  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1167 EKVTGIKEELKETHLQLDERQKK------FEELEEKLKQAQQSEQKLQQESQTSkEKLTEIQQSLQELQDSVKQKEELVQ 1240
Cdd:PTZ00108 1102 EKVEKLNAELEKKEKELEKLKNTtpkdmwLEDLDKFEEALEEQEEVEEKEIAKE-QRLKSKTKGKASKLRKPKLKKKEKK 1180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1241 NLEEKVRESSSIIEAQNTKLNESNVQLE-----NKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDS 1315
Cdd:PTZ00108 1181 KKKSSADKSKKASVVGNSKRVDSDEKRKlddkpDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEF 1260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1316 LVKVEELVKVLEEKLQAATSQLDAQQATNKEL-QELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLK 1394
Cdd:PTZ00108 1261 SSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPdGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTR 1340

                         250       260
                  ....*....|....*....|
gi 28574245  1395 ELQGKlDESNTVLESQKKSH 1414
Cdd:PTZ00108 1341 VKQAS-ASQSSRLLRRPRKK 1359
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
671-925 5.74e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  671 LLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQS 750
Cdd:COG4372   18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  751 ESEVHLQEIKAQNTQKDFELvesgESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAL 830
Cdd:COG4372   98 QAQEELESLQEEAEELQEEL----EELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  831 KVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQ 910
Cdd:COG4372  174 QALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLE 253

                        250
                 ....*....|....*
gi 28574245  911 ITKLKSEVGETQAAL 925
Cdd:COG4372  254 EVILKEIEELELAIL 268
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1191-1465 5.78e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 41.28  E-value: 5.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1191 EELEEKLKQAQQSEqkLQQESQTSKEKLTEIQQSLQELQDSVKQK----EELVQNLEEK-VRESSSIIEAQN------TK 1259
Cdd:pfam07111  128 EMVRKNLEEGSQRE--LEEIQRLHQEQLSSLTQAHEEALSSLTSKaeglEKSLNSLETKrAGEAKQLAEAQKeaellrKQ 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1260 LNESNVQLENKTSCLKETQDQLLESQKKEKQLQE---EAAKLSGELQQVQEANGDIKDSL----VKVEELVKVL---EEK 1329
Cdd:pfam07111  206 LSKTQEELEAQVTLVESLRKYVGEQVPPEVHSQTwelERQELLDTMQHLQEDRADLQATVellqVRVQSLTHMLalqEEE 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   1330 LQAATSQLDAQQAT-NKELQELLVKSQEN----EGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1404
Cdd:pfam07111  286 LTRKIQPSDSLEPEfPKKCRSLLNRWREKvfalMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKA 365

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574245   1405 TVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEK 1465
Cdd:pfam07111  366 AEVEVERMSAKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQ 426
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
386-605 5.98e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  386 RDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQcsideaqfcgdeLNAQSQVYKEKIHDLESKITKLVS 465
Cdd:COG3206  166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVD------------LSEEAKLLLQQLSELESQLAEARA 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  466 ATPSLQSILpPDLPSDDGALQEEIAKLQEKMTIQQ-----KEVESRIAEQLeeeQRLREN---VKYLNEQIATLQSELvs 537
Cdd:COG3206  234 ELAEAEARL-AALRAQLGSGPDALPELLQSPVIQQlraqlAELEAELAELS---ARYTPNhpdVIALRAQIAALRAQL-- 307

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574245  538 KDEALEKFSlsecGIENLRRELELLKEENEKQAQEAQAEFtRKLAEKSVEVLRLSSELQNLKATSDSL 605
Cdd:COG3206  308 QQEAQRILA----SLEAELEALQAREASLQAQLAQLEARL-AELPELEAELRRLEREVEVARELYESL 370
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 893-1132 6.03e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  893 ANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITd 972
Cdd:COG3883   14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  973 tlhAELQAERSSSSALHTKLSkfsdeiATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSf 1052
Cdd:COG3883   93 ---RALYRSGGSVSYLDVLLG------SESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEAL- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1053 EESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAE 1132
Cdd:COG3883  163 KAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 242
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 580-790 7.48e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 7.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  580 KLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKAdssALDDMLR 659
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE---ELGERAR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  660 -LQKEGTEEK--STLLEKTEKELVQSKEQAAKTL--NDKEQLEKQISDLKQLAEQEKLVRE---MTENAINQIQLEKESI 731
Cdd:COG3883   94 aLYRSGGSVSylDVLLGSESFSDFLDRLSALSKIadADADLLEELKADKAELEAKKAELEAklaELEALKAELEAAKAEL 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28574245  732 EQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLG 790
Cdd:COG3883  174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 910-1088 7.65e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 7.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  910 QITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA-----ELQAerss 984
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNvrnnkEYEA---- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  985 ssalhtklskFSDEIATGHKELTSKADawsqEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVT 1064
Cdd:COG1579   94 ----------LQKEIESLKRRISDLED----EILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159

                        170       180
                 ....*....|....*....|....
gi 28574245 1065 KAKTENLELSTGTQTTIKDLQERL 1088
Cdd:COG1579  160 ELEAEREELAAKIPPELLALYERI 183
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1183-1598 9.34e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 9.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1183 LDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQqSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNE 1262
Cdd:COG5185   92 KKLDTKILQEYVNSLIKLPNYEWSADILISLLYLYKSEIV-ALKDELIKVEKLDEIADIEASYGEVETGIIKDIFGKLTQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1263 SNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQA 1342
Cdd:COG5185  171 ELNQNLKKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQ 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1343 TNKELQELLVKSQENEGNLQGESlavTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHneiqdKLE 1422
Cdd:COG5185  251 TSDKLEKLVEQNTDLRLEKLGEN---AESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLA-----AAE 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1423 QAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEkGNEFDTQLAEYQKVIDEMDDA-ASVKSALLEQLQNRV 1501
Cdd:COG5185  323 AEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIE-NIVGEVELSKSSEELDSFKDTiESTKESLDEIPQNQR 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245 1502 AELETALRQANDAQKTAYLETKELRRQLESL------------ELEKSREVLSLKAQMNGASSRSGKGDEVESldieTSL 1569
Cdd:COG5185  402 GYAQEILATLEDTLKAADRQIEELQRQIEQAtssneevskllnELISELNKVMREADEESQSRLEEAYDEINR----SVR 477

                        410       420
                 ....*....|....*....|....*....
gi 28574245 1570 AKINFLNSIIADMQQKNDALKAKVQTLET 1598
Cdd:COG5185  478 SKKEDLNEELTQIESRVSTLKATLEKLRA 506
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 792-1279 9.68e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 40.81  E-value: 9.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   792 EKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLqqqaaasgEEGSKTVAKLHDEISQLKS---Q 868
Cdd:PRK10929   26 KQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVI--------DNFPKLSAELRQQLNNERDeprS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   869 AEETQSELKSTQSNLEAKSKQLEAANgSLEEEAKKSGHLLEQITKLKSEVGETQAALSschtDVESKTKQLEAANAALEK 948
Cdd:PRK10929   98 VPPNMSTDALEQEILQVSSQLLEKSR-QAQQEQDRAREISDSLSQLPQQQTEARRQLN----EIERRLQTLGTPNTPLAQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245   949 VnkEYAESRAEASDLQDKVKEItdtlhaELqAERSSSSalhtklskfSDEIATGHKELTSKADAwsqemlQKEKELQELR 1028
Cdd:PRK10929  173 A--QLTALQAESAALKALVDEL------EL-AQLSANN---------RQELARLRSELAKKRSQ------QLDAYLQALR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1029 QQLQDSQDSQTKLKAEgeRKEKsFEESIKNLQEEVTKAKTENLELSTgtqttikdlqerleITNAELQHKEKMASEdaQK 1108
Cdd:PRK10929  229 NQLNSQRQREAERALE--STEL-LAEQSGDLPKSIVAQFKINRELSQ--------------ALNQQAQRMDLIASQ--QR 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1109 IADLKTLveaiQVANAnisatnaeLSTVLEVLQAEKSETnhifelfemeadMNSERLIEKVTGIKEELKETHL-----QL 1183
Cdd:PRK10929  290 QAASQTL----QVRQA--------LNTLREQSQWLGVSN------------ALGEALRAQVARLPEMPKPQQLdtemaQL 345

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574245  1184 DERQKKFEELEEKLkqaqqseQKLQQESQTSKEKLTEIQQSLqeLQDSVKQKEELVQNLEEKVreSSSIIEAqnTKLNES 1263
Cdd:PRK10929  346 RVQRLRYEDLLNKQ-------PQLRQIRQADGQPLTAEQNRI--LDAQLRTQRELLNSLLSGG--DTLILEL--TKLKVA 412

                         490
                  ....*....|....*.
gi 28574245  1264 NVQLENktsCLKETQD 1279
Cdd:PRK10929  413 NSQLED---ALKEVNE 425
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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