|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
55-461 |
0e+00 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 642.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSLFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSPD 214
Cdd:cd17398 81 LGAWLKLFSSSPDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 215 LETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLESseaEQVSFMQSLKNLMTNRNFIFLLLSYGI 294
Cdd:cd17398 161 KDEIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRS---EDQSYLGSLKRLFKNKGFLLLLITYGI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 295 NVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTFTLDTG 374
Cdd:cd17398 238 NTGVYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 375 HIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLIV 454
Cdd:cd17398 318 SIWVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLL 397
|
....*..
gi 24586318 455 GTIITAI 461
Cdd:cd17398 398 GTILTAF 404
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
55-460 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 520.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSLFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSPD 214
Cdd:cd17456 81 LGAWIKTGSARPDLFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 215 LETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQlleSSEAEQVSFMQSLKNLMTNRNFIFLLLSYGI 294
Cdd:cd17456 161 LDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQ---SIPSQDYSYLQSILRLLKNVNFILLVVSYGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 295 NVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTFTLDTG 374
Cdd:cd17456 238 NTGCFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 375 HIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLIV 454
Cdd:cd17456 318 HLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLV 397
|
....*.
gi 24586318 455 GTIITA 460
Cdd:cd17456 398 GTILTA 403
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
55-461 |
2.14e-157 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 452.75 E-value: 2.14e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSLFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSP- 213
Cdd:cd17455 81 LGAWVKCASVRPDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTVd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 214 DLETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQeaaQLLESSEAEQVSFMQSLKNLMTNRNFIFLLLSYG 293
Cdd:cd17455 161 DIDLMGHNISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQ---AVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 294 INVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTFTLDT 373
Cdd:cd17455 238 IMTGTFYSVSTLLNQMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 374 GHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLI 453
Cdd:cd17455 318 GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIF 397
|
....*...
gi 24586318 454 VGTIITAI 461
Cdd:cd17455 398 VGIILTAL 405
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
55-462 |
5.31e-104 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 316.27 E-value: 5.31e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPS-LFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSP 213
Cdd:cd17334 81 LGSVLKCIPLGQQpKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 214 DLEtvgSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQlleSSEAEQVSFMQSLKNLMTNRNFIFLLLSYG 293
Cdd:cd17334 161 GTK---KEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQ---NSEHVILELQKSISELLRNEPFVLLAVAFS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 294 INVGVFYAISTLLNPVVLKYYpGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKettLAVYALSMVGMWIFTFTLDT 373
Cdd:cd17334 235 IMMGVFAGFSSVLAQILLPFG-VSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFK---LIGLIILALGTVVCTFFMLL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 374 -------GHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANI 446
Cdd:cd17334 311 vdryglpYVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYL 390
|
410
....*....|....*.
gi 24586318 447 TMAVMLIVGTIITAIT 462
Cdd:cd17334 391 LWFILCTVGSCLGALF 406
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
55-430 |
1.65e-78 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 251.03 E-value: 1.65e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSL-----FYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLV 209
Cdd:cd17399 81 IGAVIRVISSLPFVdpsfrFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 210 PNSPDLETvgsdLQMMFYLVAGLTsiLLVLMVIFFQDKPPTPPSAaqeaaqlleSSEAEQVSFMQSLKNLMTNRNFIFLL 289
Cdd:cd17399 161 KSSEDIFL----LLSIYTIPALIA--VVLATFGVRSSVPPTPPSA---------SAAHESEPFFVGLKQLFKNKQYLILM 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 290 LSYGINVGVFYAISTLLNPVVLKYYPGHEVdAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTF 369
Cdd:cd17399 226 LCFGGGIGLFNALSTLLEQILCPSGYSNNF-AGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586318 370 TLDT-GHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTL 430
Cdd:cd17399 305 VSRFpNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVF 366
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
55-433 |
1.87e-49 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 173.64 E-value: 1.87e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSLF-YVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVpnsp 213
Cdd:cd17397 81 AGTGLRCIPVPNHLAtWLIHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 214 dletvgsdlqmmFYLVAGLTSILLVLMVIFFQDKPPTPPSAaqeaaqlleSSEAEQVSFMQSLKNLMTNRNFIFLLLSYG 293
Cdd:cd17397 157 ------------MYLEFGWSALIFLAMLIYFPSKPPTPPSV---------SASTQRLSYKSGILSLLKNKRFWLIALAYG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 294 INVGVFYAISTLLNpVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDK-THKFKETTLAVYALSMVGMWIFTFTLD 372
Cdd:cd17397 216 IPTGVYAGWSGVLD-VNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRfGGRMKLILLLLFSGATGSFLWFTLICL 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24586318 373 T---GHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYS 433
Cdd:cd17397 295 KllpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
54-471 |
3.62e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 115.36 E-value: 3.62e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 54 ARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGT 133
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 134 CVGAWIKVFSVDPSLFYVSFIGQSIVALAqvcILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLvpnsp 213
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGG---SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 214 dLETVGsdLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAaqllesseaeqvsfMQSLKNLMTNRNFIFLLLSYG 293
Cdd:COG2223 153 -IAAFG--WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS--------------LRDQLEALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 294 INVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKeTTLAVYALSMVGMWIFTFTLDT 373
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 374 ghIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIA-ANITMAVML 452
Cdd:COG2223 295 --LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTaAFLVFAVLA 372
|
410
....*....|....*....
gi 24586318 453 IVGTIITAITQSDLRRQNA 471
Cdd:COG2223 373 LVALVLTLLLYRRPRRAAA 391
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
63-461 |
4.07e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 112.13 E-value: 4.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 63 FVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVF 142
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 143 SVDpslFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVpnspdlETVGSDL 222
Cdd:cd06174 81 APS---FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 223 QMMFYLVAGLTSILLVLMVIFFQDKPptppsaaqeAAQLLESSEAEQVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAI 302
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPP---------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 303 STLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKthkfKETTLAVYALSMVGMWIFTFTLDTG-HIAVVYL 381
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----LIGRKPLLLIGLLLMALGLALLLLApSLLLLLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 382 TASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLIVGTIITAI 461
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
55-468 |
5.41e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.17 E-value: 5.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSLFYVSFIgqsIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSpd 214
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRF---LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 215 letvgsDLQMMFYLVAGLTSILLVLmviffqdkpptppsaaqeaaqllesseaeqvsfmqslknlmtnrNFIFLLLSYGI 294
Cdd:COG2271 162 ------GWRAAFLILGLPGLLLALL--------------------------------------------RFWLLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 295 NVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTFTLDTG 374
Cdd:COG2271 192 VYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 375 HIAVVYLtaSLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLIV 454
Cdd:COG2271 272 ALAIALL--FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALL 349
|
410
....*....|....
gi 24586318 455 GTIITAITQSDLRR 468
Cdd:COG2271 350 AALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
62-422 |
2.15e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.32 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 62 LFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKV 141
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 142 FSVDPSLFYVSFIgqsIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNspdletvgSD 221
Cdd:pfam07690 81 FASSLWLLLVLRV---LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--------FG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 222 LQMMFYLVAGLtSILLVLMVIFFQDKPPTPPSAAQEAAQLlesseaeqvSFMQSLKNLMTNRNFIFLLLSYGINVGVFYA 301
Cdd:pfam07690 150 WRAAFLILAIL-SLLAAVLLLLPRPPPESKRPKPAEEARL---------SLIVAWKALLRDPVLWLLLALLLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 302 ISTLlnPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKeTTLAVYALSMVGMWIFTFTLDTGHIAVVYL 381
Cdd:pfam07690 220 LTYL--PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 24586318 382 TASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQ 422
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS 337
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
55-425 |
1.87e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 83.48 E-value: 1.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTC 134
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 135 VGAWIKVFSVDPSLFYVSFIGQsivALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNspd 214
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQ---GLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL--- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 215 letvgSDLQMMFYLVAGLTSILLVLMVIFfqdkpptppsaaqeaaqLLESSEAEQVSFMQSLKNLMTNRNFIFLLLSYGI 294
Cdd:COG2814 161 -----FGWRWVFLVNAVLALLALLLLLRL-----------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 295 NVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKeTTLAVYALSMVGMWIFTFtldTG 374
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLAL---AG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 24586318 375 HIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFG 425
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
54-461 |
3.50e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.14 E-value: 3.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 54 ARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGT 133
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 134 CVGAWIKVFSVDPSLFYVS--FIGQSIvALAQVCILSLPARlaavWFgPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPn 211
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGtaLIGAGI-AVGNVLLPGLIKR----WF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAA- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 212 spdletvGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAaqllesseaeqvsfmqSLKNLMTNRNFIFLLLS 291
Cdd:COG2807 167 -------ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA----------------SLRSLWRSPLAWLLTLF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 292 YGINVGVFYAISTLLNPvvlkYYPGHEVDAGRIG--LSIV-LAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFT 368
Cdd:COG2807 224 FGLQSLLYYAVVAWLPP----ILRDAGLSAATAGllLSLFqLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 369 FTLDtghiAVVYLTASLLGFFMTGYLPVGFEFGAELTfpePEGTSSGLLNASAQTFGICF----TLFYSELFTTFGD-IA 443
Cdd:COG2807 300 LAPG----SLPWLWAVLLGLGQGGLFPLALTLIGLRA---RTPAEAAALSGMAQSVGYLLaalgPLLVGALHDATGSwTA 372
|
410
....*....|....*...
gi 24586318 444 ANITMAVMLIVGTIITAI 461
Cdd:COG2807 373 ALLLLAALAVLMLVAGLL 390
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
149-396 |
8.03e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.40 E-value: 8.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 149 FYVSFIG-QSIVALAQVCILSLPARLAAvwfGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSPDLETVGsdLQMMFY 227
Cdd:COG2211 113 ALVTYLLlGLAYTLVNIPYSALGAELTP---DYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALG--YRLTAL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 228 LVAGLTSILLVLMVIFFQDKPPTppsaaqeaaqllessEAEQVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLN 307
Cdd:COG2211 188 IFAVLGLLAFLLTFFGTKERPVP---------------EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLL 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 308 PVVlKYYPGHEVD-AGRIGLSIVLAGMLGSVVSGIVLDKTHKfKETTLAVYALSMVGMWIFTFtLDTGHIAVVYLTASLL 386
Cdd:COG2211 253 YYF-KYVLGLSAAlVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALA 329
|
250
....*....|
gi 24586318 387 GFFMTGYLPV 396
Cdd:COG2211 330 GIGLGAILVL 339
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
55-459 |
2.45e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 59.16 E-value: 2.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 55 RRWAVLILFVfysSSNAMQWIQYT--IINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVG 132
Cdd:cd17353 1 RRWLVLLGAV---LMHLILGYQYAwsVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 133 TCVGAWIKVFSVDPSLFYVSF-----IGQSIValaqvciLSLPARLAAVWFgPDQVSSATSVGVFGNQLGVAVGFVLPPM 207
Cdd:cd17353 78 FGLGFILSAFAISLPLLFLGYgvlggIGAGIG-------YITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 208 LvpnspdLETVGsdLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLESSEAEQVSFMQSLKnlmtNRNFIF 287
Cdd:cd17353 150 L------INTVG--VPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLR----TPTFWL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 288 LLLSYGINVGVFYAISTLLNPVVlKYYPGHEVDAGRIGLSIV-LAGMLGSVVSGIVLDKThKFKETTLAVYALSMVGMWI 366
Cdd:cd17353 218 LWLMFFLNATAGLMLIGQAKPIG-QEFAGLDAGIAALAVSILsIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 367 FTFTldTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANI 446
Cdd:cd17353 296 LPFI--GSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFI 373
|
410
....*....|...
gi 24586318 447 TMAVMLIVGTIIT 459
Cdd:cd17353 374 IAAALSLVALALA 386
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
101-461 |
6.93e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.58 E-value: 6.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 101 IYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIgqsIVALAQVCILSLPARLAAVWFGP 180
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF---LLGVAEAGFFPGAIKALAEWFPA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 181 DQVSSATSVGVFGNQLGVAVGFVLPPMLvpnspdLETVGsdLQMMFYLVAGLTSILLVLMVIFFqdkpptppsaaqeaaq 260
Cdd:cd17319 123 RERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG--WRWAFIIEGLLGLLLAVLWWFYL---------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 261 llesseaeqvsfmqslknlmtnRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSG 340
Cdd:cd17319 179 ----------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 341 IVLDKTHKFKETTLAV--YALSMVGMWIFTFtldTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLN 418
Cdd:cd17319 237 RLSDRLLRGARRLVIIigLLLAAVGLLLAYL---TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLIN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 24586318 419 ASAQTFGICFTLFYSELFTTFGD-IAANITMAVMLIVGTIITAI 461
Cdd:cd17319 314 SGGNLGGFVAPLLIGYLVDATGSyTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
84-460 |
2.18e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.02 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 84 ITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDpslFYVSFIGQSIVALAQ 163
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS---FALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 164 VCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLvpnspdLETVGsdLQMMFYLVAGLTSILLVLMVIF 243
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLG--WRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 244 FqdkPPTPPSAAQeaaqllesseaeQVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGHEVDAGR 323
Cdd:cd17324 174 L---PSLPPKKPG------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 324 IGLSIVLAGMLGSVVSGIVLDKTHKFkeTTLAVYALSMVGMWIFTFTLdtGHIAVVYLTASLLGFFMTGYLPVGFEFGAE 403
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRR--ALLIALLLLAAALLLLTLLG--PSPLLLLVGLVLWGLGFFAAHSALQTRVLR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 24586318 404 LTfPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLIVGTIITA 460
Cdd:cd17324 315 LA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
77-461 |
2.82e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 2.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 77 YTIINNIITRY---YGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSF 153
Cdd:cd17325 12 YGIIIPILPLYaesLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 154 IGQSIVAlaqvcILSLPARLAAV--WFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPnspdletvGSDLQMMFYLVAG 231
Cdd:cd17325 92 FLQGLAS-----AAVWPAAMALIadIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 232 LTSILLVLMVIFFQDKPPTPPSAAQEAAqllesseaeqvSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVL 311
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAA-----------RLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 312 KYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKtHKFKETTLAVYALSMVGMWIFTFtldTGHIAVVYLTASLLGFFMT 391
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPL---ATSFWLLLLLLALLGLGLG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24586318 392 GYLPVGFEFGAELTFPEPEGTSSGLLNaSAQTFGICF-TLFYSELFTTFGDIAANITMAVMLIVGTIITAI 461
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFN-TAFSLGMVLgPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
115-422 |
2.89e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 2.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 115 WFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIgqsIVALAQVCILSLPARLAAVWFGPDQVSS-ATSVGVFG 193
Cdd:cd17355 60 RLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWG---LLGGGGAGTLAAVAFATVAAWWFERRRGlALGILTAG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 194 NQLGvavGFVLPPMLVpnspdLETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAqeaaqlleSSEAEQVSFM 273
Cdd:cd17355 137 GGLG---SLVFLPLGA-----ALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRA--------YDDASPASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 274 QSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLsIVLAGMLGSVVSGIVLDKTHKfKETT 353
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL-IGLFNIVGRLLSGWLGDRYSP-RRLL 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24586318 354 LAVYALSMVGMWIFTFTLDTGHIAVVYltASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQ 422
Cdd:cd17355 279 AASYALRALGLALLLLLPFPPLALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
111-460 |
1.37e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.40 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 111 FPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIgqsIVALAQVCILSLPARLAAVWFGPDQVSSATSVG 190
Cdd:cd17475 49 LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF---LVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 191 VFGNQLGVAVGFVLPPMLVpnspdletVGSDLQMMFyLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLEsseaeqv 270
Cdd:cd17475 126 QTGVPLGGALAAALLPPLA--------LHYGWRAAF-VVAGLVSILAAVLFWLFYREPPAASAATESASTLLR------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 271 sfmqSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLnPVVLKYYPGHEVDAGRIGLSIV-LAGMLGSVVSGIVLDKTH-- 347
Cdd:cd17475 190 ----SLKEVLRNRDVWLIAIAGALLVAPQFALLTFL-LLFLHDHLGLSVVAAGALLAVAqLGGALGRIGLGRVSDRVFgg 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 348 KFKETTLAVYALSMVGMWIFTFTLDTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQtFGIC 427
Cdd:cd17475 265 RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINF-IGIA 343
|
330 340 350
....*....|....*....|....*....|....*
gi 24586318 428 FT--LFYSELFTTFGDIAANITMAVMLIVGTIITA 460
Cdd:cd17475 344 IGppLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-417 |
1.53e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.32 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 56 RWAVLILFVFYSSSNAMqwiqYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCV 135
Cdd:COG0738 10 LIAIYLLFFLWGFATAL----WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 136 GAWIKVFSVDPSLFYVSFIGQSI-VALAQVCILSLparlaAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVpnspd 214
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLgLGLLDVAANPY-----VAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 215 LETVGSDLQMMFYLVAGltsILLVLMVIFFQDKPPTPpsaaqeaaqllESSEAEQVSFMQSLKNLMTNRNFIFLLLSYGI 294
Cdd:COG0738 156 LLGLSLSWHLPYLILAV---LLLLLALLFLRSKLPEI-----------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 295 NVGVFYAISTLLnPVVLKYYPGHEVDAGRIGLSIVLAGM-LGSVVSGIVLDkthKFK-ETTLAVYA-LSMVGMWIFTFtl 371
Cdd:COG0738 222 YVGAEGAIGDWL-PLYLKDVLGLSEATAALGLSLFWGGMtIGRFLGGFLLK---RFGpVRLLRLSAlLAAVGLLLALL-- 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 24586318 372 dTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLL 417
Cdd:COG0738 296 -APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL 340
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-244 |
1.96e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 43 HNPPAEGYKVYARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGL 122
Cdd:COG2211 214 KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 123 RITALVGIVGTCVGAWIKVFsVDPSLFYVSFIGQSIVALAQVCILSLP-------ARLAAVWFGPDQVSSATSVGVFGNQ 195
Cdd:COG2211 294 KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPwamladvVDYDEWKTGRRREGLYFGIFTFAIK 372
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 24586318 196 LGVAVGFVLPPML------VPNSPDLETVGSDLQMMFYLVAGLTSILLVLMVIFF 244
Cdd:COG2211 373 LGQALAGALAGLLlalfgyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFY 427
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
84-455 |
2.13e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.80 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 84 ITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIGQSI-VALA 162
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLgAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 163 QVCILSLPArlaavwfgpDQVSSATSVGVFGnQLGVAVGFVlpPMLVPnspdleTVGSDLQM------MFYLVAGLTSIL 236
Cdd:cd17320 105 SVVARAIVR---------DLYSGAELAKIFS-LLMMILAIA--PALAP------LLGGLLLLffgwraIFVFLALLGLLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 237 LVLMVIFFqdkPPTPPSAAQEAAQllesseaeqVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPG 316
Cdd:cd17320 167 LLLVLLFL---PETLPEEKRKPLL---------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 317 HEVDAGRIGLSIVLAGMLGSVVSGIVLDK--THKFKETTLAVYALSMVGMWIFTFTLD-TGHIAVVYLTASLLGFFMTGy 393
Cdd:cd17320 235 SPAQFGLLFALNAIALILGSLLNGRLVRRfgPRRLLRLGLLLLLAAALVLLLAALLGGlSLWPLVAPLFLIFFGFGLIF- 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586318 394 lPVGFEFGAELtFPEPEGTSSGLLNaSAQTFGICFTLFYSELFTTFGDIAANITMAVMLIVG 455
Cdd:cd17320 314 -PNATSLALEP-FPHVAGTASALLG-FLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLA 372
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
149-398 |
2.78e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.44 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 149 FYVSFIGQSIV-ALAQVCILSLPARLAAvwfGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPN-SPDLETVGSDLQMMF 226
Cdd:cd17332 102 ALITYILLDLLyTLVNIPYTALIPELTD---DPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYfGGGNASRGYFLTALI 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 227 YLVAGLTSILLVlmviFFQDKPPTPPSAAQeaaqllesseAEQVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLL 306
Cdd:cd17332 179 IGIIGIILLLIC----FFGTRERVVPPEEE----------KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVL 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 307 nPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKT--HKFKETTLAVYALSMVGMWIFTFtldtGHIAVVYLTAS 384
Cdd:cd17332 245 -VYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFgkKKAFFIGLLLAILGLLLLFFLPP----GNLVLILVLAV 319
|
250
....*....|....
gi 24586318 385 LLGFFMTGYLPVGF 398
Cdd:cd17332 320 LAGIGYGGANLLPW 333
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
103-460 |
2.99e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.09 E-value: 2.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 103 MILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGA-WIKVFSVDPSLFYVS--FIGQSIVALAqVCIlslpaRLAAVWFG 179
Cdd:cd17341 44 VLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlALALAVSSYWGLLVLgfLLGFAGANFA-SGQ-----PWASFWFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 180 PDQVSSATSVGVFGNQLGVAVGFVLPPMLVpNSPDLETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQeaa 259
Cdd:cd17341 118 KEKIGGAAGGIAGAGNMGVAVSQLLAPLIA-GAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE--- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 260 qllesseaeqvsFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVS 339
Cdd:cd17341 194 ------------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 340 GIVLDKtHKFKETTLAVYALSMVGMWIFTFTLDTGHIAVVYLTASLLGFFMTgylpVGFEFGA-----ELTFPEPEGTSS 414
Cdd:cd17341 262 GWLSDR-FGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG----AGAGNGSvfrmvPFIFRRELGAVT 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 24586318 415 GLLNASAQTFGICFTLFYSELFTTFGDIAANIT-MAVMLIVGTIITA 460
Cdd:cd17341 337 GLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSlFGVLAVACTLLVW 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
283-461 |
4.24e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 283 RNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKetTLAVYALSMV 362
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK--TLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 363 GMWIFTFTLDTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDI 442
Cdd:cd17316 255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
170
....*....|....*....
gi 24586318 443 AANITMAVMLIVGTIITAI 461
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
56-240 |
4.75e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 4.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 56 RWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCV 135
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 136 GAWIKVFSVDPSLFYVSFIGQSIVALAQVCILSLPARLAAVWfgPDQVsSATSVGvFGNQLGVAVGFVLPPMLvpnSPDL 215
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELF--PTEV-RATGVG-LSYNLGRLGGGGAPPLI---ALLL 328
|
170 180
....*....|....*....|....*
gi 24586318 216 ETVGSDLQMMFYLVAGLTSILLVLM 240
Cdd:cd17316 329 ASTGGTGVPALILALLAIVALIVAL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
113-392 |
9.33e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.65 E-value: 9.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 113 GSWFLDKVGLRITALVGIVGTCVGAWIKVFSVD-PSL-FYVSFIGQSIVALAQVCILslparLAAVWFGPDQVSSATSVG 190
Cdd:TIGR00895 72 FGPLADRIGRRRVLLWSILLFSVFTLLCALATNvTQLlILRFLAGLGLGGLMPNLNA-----LVSEYAPKRFRGTAVGLM 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 191 VFGNQLGVAVGFVLPPMLVPNspdletvgSDLQMMFYlVAGLTSILLVLMVIFFQDKP--------------------PT 250
Cdd:TIGR00895 147 FCGYPIGAAVGGFLAGWLIPV--------FGWRSLFY-VGGIAPLLLLLLLMRFLPESidflvskrpetvrrivnaiaPQ 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 251 PPSAAQEAAQLLESSEAEQVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLnPVVLKYYPGHEVDAGRIGLSIVL 330
Cdd:TIGR00895 218 MQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWL-PKLMVELGFSLSLAATGGALFNF 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24586318 331 AGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTFTLDTGhiavVYLTASLLGFFMTG 392
Cdd:TIGR00895 297 GGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTL----LLLLGAIAGFFVNG 354
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
104-426 |
3.09e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 104 ILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSvdPSLFyVSFIGQSIVALAQVCILSLPARLAAVWFGPDQV 183
Cdd:TIGR00881 41 IAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS--TSLW-VMAALWALNGIFQGMGWPPCGRTVTKWFSRSER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 184 SSATSVGVFGNQLGvavGFVLPPMlvpnspdletVGSDLQMMF-----YLVAGLTSILLVLMV-IFFQDKPPTP--PSAA 255
Cdd:TIGR00881 118 GTWVSFWNCSHNVG---GGLLPPL----------VLFGIAELYswhwvFIVPGIIAIIVSLICfLLLRDSPQSCglPPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 256 QEAAQLLESSEAEQVSFMQSLKNLMT----NRNFIFLLLSYGINVGVFYAISTLLnPVVLKYYPGHEVDAGRIGLSIV-L 330
Cdd:TIGR00881 185 EMPNEEPDGDAEKKEEELTKKQIFLQyvllNKVLWYISLGYVFVYVVRTGILDWS-PLYLTQEKGFSKEKASWAFTLYeL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 331 AGMLGSVVSGIVLDKTHKFKETTLAVY--ALSMVGMWIFTFTLdTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPE 408
Cdd:TIGR00881 264 GGLVGTLLAGWLSDKLFNGRRGPLAVFfmALIIVSLLVYWLNP-AANPLMDLICLFALGFLVYGPQMLIGVIASELAPKK 342
|
330
....*....|....*...
gi 24586318 409 PEGTSSGLLNASAQTFGI 426
Cdd:TIGR00881 343 AAGTAAGFVGFFAYLGGI 360
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
225-390 |
8.19e-04 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 41.80 E-value: 8.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 225 MFYLVAGLTSILLVLMVIFFqdkPPTPPSAAQEAAQLLESSEAEQVS-----------------FMQSLKNLMTNRNFIF 287
Cdd:pfam03137 174 LGFLIAGLLLLLTAIPFFFF---PKSLPGAAKRRAKKKKEPHSQDIAdlkktkslkklgpslkdFPKALKRLLKNPVYML 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 288 LLLSYGINVGVFYAISTLLNpvvlKY------YPGHEVdAGRIGLSIVLAGMLGSVVSGIVLDkthKFKettlavyaLSM 361
Cdd:pfam03137 251 LTLASVFEFLLIAGYATFLP----KYietqfgLSASTA-NLLTGVVAIPGAALGILLGGLIIK---KFK--------LSA 314
|
170 180
....*....|....*....|....*....
gi 24586318 362 VGMWIFTFTldtghIAVVYLTASLLGFFM 390
Cdd:pfam03137 315 KGLAKFNVI-----TSLVSLLLSLLLFFL 338
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-201 |
1.24e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 28 TPKEKEGKGLKVAGGHNPPAEGYKVYARRWAVLILFVFYSSSNAMQWIQYTIinNIITRYYGISDKWVDWTSMIYMILYI 107
Cdd:pfam07690 172 RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL--PLYQEVLGLSALLAGLLLGLGGLLGA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 108 PLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSAT 187
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
170
....*....|....
gi 24586318 188 SVGVFGNQLGVAVG 201
Cdd:pfam07690 330 GLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
45-200 |
4.80e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 4.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 45 PPAEGYKVYARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRI 124
Cdd:COG2814 195 RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24586318 125 TALVGIVGTCVGAWIKVFSVDPSLFYVSFIGQSI-VALAQVCILSLPARLaavwFGPDQVSSATSVGVFGNQLGVAV 200
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFgFGLLFPLLQALVAEL----APPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
76-461 |
5.47e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 76 QYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFig 155
Cdd:cd17352 21 SFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTY-- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 156 qSIVALAQVCILSLPARLA-AVWFGpDQVSSATSVGVFGNQLGvavGFVLPPMLvpnSPDLETVGsdLQMMFYLVAGLTS 234
Cdd:cd17352 99 -GVLGGLGLGLIYSPAIVIvGQYFE-KKRGLATGIAVAGSGVG---TFVFPPLL---RYLLDNYG--WRGALLILGGLCL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 235 ILLVLMVIFfqdkpptppsaaqeaaQLLesseaeqvsfmqslknlmtnRNFIFLLLSYGINVGVF-YAISTLLNPVVLKY 313
Cdd:cd17352 169 NLCVCGLLL----------------RLL--------------------KDPTFVLLALGVSFAMLgFFVPFVYLPSYAKS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586318 314 YPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKThKFKETTLAVYALSMVGMWIFTFTLDTgHIAVVYLTASLLGFFMTGY 393
Cdd:cd17352 213 LGIDESDAAFLLSIIGISDIVGRILLGLLADKP-RIGRLYLYIFTLLILGLSLLAFPLAT-TYVGLIVFSVLFGFCSGSY 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24586318 394 LPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGD-IAANITMAVMLIVGTIITAI 461
Cdd:cd17352 291 SSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDyDAAFYFCGACLLLSGVLLFL 359
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