NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24652337|ref|NP_724890|]
View 

phosphofructokinase, isoform B [Drosophila melanogaster]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 11494308)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 18-767 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


:

Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1303.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMT 177
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQ 257
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   258 RLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVV 337
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   338 ISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIegyRLAVMHI 417
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEASRL---RIAIIHV 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   418 GAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEF 497
Cdd:TIGR02478 398 GAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQH 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   498 KIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVF 577
Cdd:TIGR02478 478 KIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVF 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   578 VIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEG 657
Cdd:TIGR02478 558 VVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEG 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   658 KGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCksPDTATLLGIVSRQYRFSPLVD-L 736
Cdd:TIGR02478 638 KGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD--DTSAVVIGIRGSNVLFTPVKQlL 715

                         730       740       750
                  ....*....|....*....|....*....|.
gi 24652337   737 IAETNFDQRIPKKQWWLRLRPLLRILAKHDS 767
Cdd:TIGR02478 716 ANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 18-767 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1303.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMT 177
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQ 257
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   258 RLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVV 337
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   338 ISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIegyRLAVMHI 417
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEASRL---RIAIIHV 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   418 GAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEF 497
Cdd:TIGR02478 398 GAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQH 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   498 KIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVF 577
Cdd:TIGR02478 478 KIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVF 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   578 VIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEG 657
Cdd:TIGR02478 558 VVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEG 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   658 KGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCksPDTATLLGIVSRQYRFSPLVD-L 736
Cdd:TIGR02478 638 KGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD--DTSAVVIGIRGSNVLFTPVKQlL 715

                         730       740       750
                  ....*....|....*....|....*....|.
gi 24652337   737 IAETNFDQRIPKKQWWLRLRPLLRILAKHDS 767
Cdd:TIGR02478 716 ANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-752 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1054.42  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  16 KDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFR 95
Cdd:cd00764   2 AGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  96 ERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTD 175
Cdd:cd00764  82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 176 MTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSA 255
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSR 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 256 GQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVP 335
Cdd:cd00764 242 GKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPA 321

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 336 VVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKML--TRLKPPKENfdadgkgiEGYRLA 413
Cdd:cd00764 322 CVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLaiELPQPLPEK--------TNLNIA 393

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 414 VMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAAR 493
Cdd:cd00764 394 IVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYN 473

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 494 LKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTK 573
Cdd:cd00764 474 FQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTK 553

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 574 RRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLY 653
Cdd:cd00764 554 RRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELY 633

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 654 SEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIdANGVVNCKSPDTATLLGIVSRQYRFSPl 733
Cdd:cd00764 634 SEEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENY-AAGNEFANDPDFNCVNGVKKYAVLFEP- 711

                       730
                ....*....|....*....
gi 24652337 734 VDLIAETNFDQRIPKKQWW 752
Cdd:cd00764 712 VEELKQTTFEHRIPKEQWW 730
PFK pfam00365
Phosphofructokinase;
20-322 8.15e-141

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 415.59  E-value: 8.15e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    20 LAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRERQG 99
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   100 RLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSslldelvknktitteqqekfnvLHIVGLVGSIDNDFCGTDMTIG 179
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   180 TDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLaQERSAGQRL 259
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDI---EELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24652337   260 NIVIVAEGAMDreghpitAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEA 322
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKA 269
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
18-374 1.27e-130

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 391.37  E-value: 1.27e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGD--IVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFrqewsslldelvknktitTEqqEKFNVlhiVGLVGSIDNDFCGTDMT 177
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL------------------TE--HGIPV---IGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLAQERSAGQ 257
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI---EELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  258 RLNIVIVAEGAMDreghpitAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDsvpVV 337
Cdd:PRK03202 214 KHAIIVVAEGVMP-------AEELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGG---RM 283

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 24652337  338 ISLDGNQAVRVPLMECVERTQAVAKamaeKRWADAVK 374
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVENMKHPFD----KDLYELAK 316
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 20-360 7.29e-121

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 367.09  E-value: 7.29e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  20 LAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRERQG 99
Cdd:COG0205   4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKTEEG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 100 RLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSslldelvknktitteqqekfnvLHIVGLVGSIDNDFCGTDMTIG 179
Cdd:COG0205  82 REKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIG 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 180 TDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLAQERSAGQRL 259
Cdd:COG0205 140 FDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDL---DKLLEKLKERRKRGKGY 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 260 NIVIVAEGAMDREGHPI---------------TAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATL 324
Cdd:COG0205 217 SIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVE 296

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 24652337 325 ALMEATKDsvpVVISLDGNQAVRVPLMECVERTQAV 360
Cdd:COG0205 297 LLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPV 329
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 18-767 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1303.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMT 177
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQ 257
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   258 RLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVV 337
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   338 ISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIegyRLAVMHI 417
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEASRL---RIAIIHV 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   418 GAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEF 497
Cdd:TIGR02478 398 GAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQH 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   498 KIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVF 577
Cdd:TIGR02478 478 KIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVF 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   578 VIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEG 657
Cdd:TIGR02478 558 VVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEG 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   658 KGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCksPDTATLLGIVSRQYRFSPLVD-L 736
Cdd:TIGR02478 638 KGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD--DTSAVVIGIRGSNVLFTPVKQlL 715

                         730       740       750
                  ....*....|....*....|....*....|.
gi 24652337   737 IAETNFDQRIPKKQWWLRLRPLLRILAKHDS 767
Cdd:TIGR02478 716 ANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-752 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1054.42  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  16 KDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFR 95
Cdd:cd00764   2 AGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  96 ERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTD 175
Cdd:cd00764  82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 176 MTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSA 255
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSR 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 256 GQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVP 335
Cdd:cd00764 242 GKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPA 321

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 336 VVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKML--TRLKPPKENfdadgkgiEGYRLA 413
Cdd:cd00764 322 CVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLaiELPQPLPEK--------TNLNIA 393

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 414 VMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAAR 493
Cdd:cd00764 394 IVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYN 473

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 494 LKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTK 573
Cdd:cd00764 474 FQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTK 553

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 574 RRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLY 653
Cdd:cd00764 554 RRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELY 633

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 654 SEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIdANGVVNCKSPDTATLLGIVSRQYRFSPl 733
Cdd:cd00764 634 SEEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENY-AAGNEFANDPDFNCVNGVKKYAVLFEP- 711

                       730
                ....*....|....*....
gi 24652337 734 VDLIAETNFDQRIPKKQWW 752
Cdd:cd00764 712 VEELKQTTFEHRIPKEQWW 730
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 18-385 2.78e-161

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 471.01  E-value: 2.78e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:cd00363   1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGD--IKELDWESVSDIINRGGTIIGSARCKEFRTE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLldelvknktitteqQEKFNVlhiVGLVGSIDNDFCGTDMT 177
Cdd:cd00363  79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSK--------------YQGFNV---IGLPGTIDNDIKGTDYT 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQ 257
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 258 RLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVV 337
Cdd:cd00363 222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 24652337 338 ISLDGNQAVRVPLMECVERTQAVakamaekrwadAVKLRGRSFERNLE 385
Cdd:cd00363 302 QNLNENQVVRHPLTEAVNMTKRV-----------GVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
20-322 8.15e-141

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 415.59  E-value: 8.15e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    20 LAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRERQG 99
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   100 RLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSslldelvknktitteqqekfnvLHIVGLVGSIDNDFCGTDMTIG 179
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   180 TDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLaQERSAGQRL 259
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDI---EELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24652337   260 NIVIVAEGAMDreghpitAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEA 322
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKA 269
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
18-374 1.27e-130

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 391.37  E-value: 1.27e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGD--IVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFrqewsslldelvknktitTEqqEKFNVlhiVGLVGSIDNDFCGTDMT 177
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL------------------TE--HGIPV---IGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLAQERSAGQ 257
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI---EELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  258 RLNIVIVAEGAMDreghpitAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDsvpVV 337
Cdd:PRK03202 214 KHAIIVVAEGVMP-------AEELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGG---RM 283

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 24652337  338 ISLDGNQAVRVPLMECVERTQAVAKamaeKRWADAVK 374
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVENMKHPFD----KDLYELAK 316
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 20-360 7.29e-121

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 367.09  E-value: 7.29e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  20 LAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRERQG 99
Cdd:COG0205   4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKTEEG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 100 RLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSslldelvknktitteqqekfnvLHIVGLVGSIDNDFCGTDMTIG 179
Cdd:COG0205  82 REKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIG 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 180 TDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLAQERSAGQRL 259
Cdd:COG0205 140 FDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDL---DKLLEKLKERRKRGKGY 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 260 NIVIVAEGAMDREGHPI---------------TAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATL 324
Cdd:COG0205 217 SIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVE 296

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 24652337 325 ALMEATKDsvpVVISLDGNQAVRVPLMECVERTQAV 360
Cdd:COG0205 297 LLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPV 329
PFK pfam00365
Phosphofructokinase;
411-694 4.00e-110

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 336.62  E-value: 4.00e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   411 RLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLP---EGKF 487
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPfktEEGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   488 KEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDnypqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQ 567
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   568 SAQGTkRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHmaskMAEGVSRGLILRNEKASEnysTD 647
Cdd:pfam00365 155 TASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKE----LRKGKRFSIIVVAEGASD---GE 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 24652337   648 FIYRLYsEEGKGlFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVD 694
Cdd:pfam00365 227 FLAKLI-EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 20-352 2.04e-109

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 335.86  E-value: 2.04e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    20 LAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRERQG 99
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGK--IEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   100 RLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEwsslldelvknktitteqqekfNVLHIVGLVGSIDNDFCGTDMTIG 179
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE----------------------GGIPVIGLPGTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   180 TDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPpkVDwPDRLCSQLAQERSAGQRL 259
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFD--YD-IDELIQRLKEQHEAGKKH 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   260 NIVIVAEGAMDREGHpitaeDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDsvpVVIS 339
Cdd:TIGR02482 215 SIIIVAEGNIVGSAK-----EVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGG---VMIG 286

                         330
                  ....*....|...
gi 24652337   340 LDGNQAVRVPLME 352
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 18-364 1.53e-104

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 323.98  E-value: 1.53e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIGSARCQDFRER 97
Cdd:cd00763   1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGD--IVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFrqewsslldelvknktitTEqqEKFNVlhiVGLVGSIDNDFCGTDMT 177
Cdd:cd00763  79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAMRL------------------TE--HGFPC---VGLPGTIDNDIPGTDYT 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKvdwPDRLCSQLAQERSAGQ 257
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 258 RLNIVIVAEGAMDreghpitAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDsvpVV 337
Cdd:cd00763 213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGG---LA 282

                       330       340
                ....*....|....*....|....*..
gi 24652337 338 ISLDGNQAVRVPLMECVERTQAVAKAM 364
Cdd:cd00763 283 VGIQNEQLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 20-354 9.81e-80

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 259.16  E-value: 9.81e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    20 LAVFTSGGDSQGMNAAVRACVRMAIY-LGCKVYFIREGYQGMVDGgDCIQEANWASVSSIIHRGGTIIGSARCQDFR-ER 97
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAeYGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    98 QGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQewsslldelvknktitteqqekfNVLHIVGLVGSIDNDFCGTDMT 177
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIARRLAD-----------------------KGLPVVGVPKTIDNDLEATDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   178 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQLAQERSAGQ 257
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFDI---DSVCEKVRERFARGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   258 RLNIVIVAEGAMDREGHPITAEDVKKV----------------IDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAE 321
Cdd:TIGR02483 215 RFAIVVVAEGAKPKGGEMVVQEGVKDAfghvrlggignwlaeeIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294

                         330       340       350
                  ....*....|....*....|....*....|...
gi 24652337   322 ATLALMEATKDsvpVVISLDGNQAVRVPLMECV 354
Cdd:TIGR02483 295 AVDLVHEGQFG---HMVALRGTDIVYVPIAEAV 324
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 411-698 8.89e-58

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 200.69  E-value: 8.89e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 411 RLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLP---EGKF 487
Cdd:COG0205   3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPfktEEGR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 488 KEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDnypqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQ 567
Cdd:COG0205  83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 568 SAQGTkRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASK--------MAEGVSRGLIlrnEK 639
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRgkgysiivVAEGAGDEDG---EA 232

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24652337 640 ASENYSTDFIYRLYSEEGKGL---------FTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAA 698
Cdd:COG0205 233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 411-696 2.93e-56

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 196.37  E-value: 2.93e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 411 RLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRT----LPEGk 486
Cdd:cd00363   2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCkefrTEEG- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 487 FKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIR 566
Cdd:cd00363  81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQG-FNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 567 QSAQgTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQdvyhMASKMAEGVSRG----LILRNEKAse 642
Cdd:cd00363 160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEE----MVDVIKKRRERGkrhgIVIVAEGA-- 232

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24652337 643 nysTDFIYRLYSEEG-------KGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWL 696
Cdd:cd00363 233 ---IDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELL 290
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
411-697 4.37e-55

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 192.22  E-value: 4.37e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  411 RLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTlPEGKFKEI 490
Cdd:PRK03202   3 RIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARF-PEFKDEEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  491 AAR----LKEFKIQGLLIIGGFESYHAAGQIADQRdnypqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIR 566
Cdd:PRK03202  82 RAKaienLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  567 QSAQgTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLqqdvyhmASKMAEGVSRG----LILRNEKA-S 641
Cdd:PRK03202 155 DTAS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL-------CAKIKKGRERGkkhaIIVVAEGVmP 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24652337  642 ENYSTDFIyrlyseEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLA 697
Cdd:PRK03202 227 AEELAKEI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLL 276
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 8-333 9.69e-54

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 198.72  E-value: 9.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337     8 RFLARGSQKDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGdcIQEANWASVSSIIHRGGTIIG 87
Cdd:TIGR02478 380 KKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELG 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    88 SAR---CQDFRERQGRLKaannliQRGITNLVVIGGDGSLTGANlfrqewsslldELVKNKtittEQQEKFNVlHIVGLV 164
Cdd:TIGR02478 458 TNRslpGDDLGTIAYYFQ------QHKIDGLIIIGGFEAFEALY-----------QLDAAR----EKYPAFRI-PMVVIP 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   165 GSIDNDFCGTDMTIGTDTALHRIIEAIDAIS-STAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPD 243
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKqSASASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   244 RLCSQLAQERSAGQRLNIVIVAEGAmdreGHPITAEDVKKVIDERLK--HDARITVLGHVQRGGNPSAFDRILACRMGAE 321
Cdd:TIGR02478 596 EDIEHLKETFAEGRAGKLILRNEKA----SKVYTTDFIARIISEEGKgrFDARTAVLGHMQQGGSPSPFDRVRATRLAIR 671

                         330
                  ....*....|..
gi 24652337   322 ATLALMEATKDS 333
Cdd:TIGR02478 672 AVDFIEEKIKAN 683
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
18-360 9.97e-53

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 187.20  E-value: 9.97e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   18 KGLAVFTSGGDSQGMNAAVRACVRMAI-YLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQD--- 93
Cdd:PRK14071   5 KRIGILTSGGDCAGLNAVIRAVVHRARgTYGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKGDpfa 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   94 FRERQGRLKAANNLI-----QRGITNLVVIGGDGSLtganlfrqewsSLLDELVknktitteQQEKFNvlhIVGLVGSID 168
Cdd:PRK14071  85 FPMPDGSLRDRSQEIidgyhSLGLDALIGIGGDGSL-----------AILRRLA--------QQGGIN---LVGIPKTID 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  169 NDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVdwpDRLCSQ 248
Cdd:PRK14071 143 NDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL---ENVCKK 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  249 LAQERSAGQRLNIVIVAEGAMDREGHPITAED-------------VKKVIDERLKHDARITVLGHVQRGGNPSAFDRILA 315
Cdd:PRK14071 220 IRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLA 299

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 24652337  316 CRMGAEATLALMEATKDSvpvVISLDGNQAVRVPLMECVERTQAV 360
Cdd:PRK14071 300 SAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAV 341
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 411-698 1.17e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 185.69  E-value: 1.17e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 411 RLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRtLPEGKFKEI 490
Cdd:cd00763   2 RIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 491 AAR----LKEFKIQGLLIIGGFESYHAAGQIADQRdnypqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIR 566
Cdd:cd00763  81 QAKaieqLKKHGIDALVVIGGDGSYMGAMRLTEHG-------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIR 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 567 QSAQgTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVyhmASKMAEGVSRGLILRNEKAsenYST 646
Cdd:cd00763 154 DTSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRI---KAGIERGKKHAIVVVAEGV---YDV 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 24652337 647 DFIYRLYSEEGKglFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAA 698
Cdd:cd00763 227 DELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA 276
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 21-385 1.68e-28

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 119.76  E-value: 1.68e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   21 AVFTSGGDSQGMNAAVRACVRMAIY-LGCK-VYFIREGYQGMVdggdciqEANW-----ASVSSIIHRGGTIIGSARCQD 93
Cdd:PTZ00286  91 GIVTCGGLCPGLNVVIRELVMNLINnYGVKtIYGAKYGYKGLY-------KEDWikldpKDVKTIHRLGGTILGSSRGGF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   94 FRErqgrlKAANNLIQRGITNLVVIGGDGSLTGANlfrqewsSLLDELVKNK-TITteqqekfnvlhIVGLVGSIDNDFC 172
Cdd:PTZ00286 164 DPK-----VMVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKTIDNDIP 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  173 GTDMTIGTDTALHRIIEAIDAISSTAYSHQRTF-IMEVMGRHCGYLALVGGLAC-EADFIFIPEMppkvDWPDRLCSQLA 250
Cdd:PTZ00286 221 IIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASaDVNVCLIPEF----DIPLEGVLEYI 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  251 QERSAGQRLNIVIVAEGAMD--REGHPITAED-------------VKKVIDERLKHDARITVLGHVQ-----RGGNPSAF 310
Cdd:PTZ00286 297 EQRLQKKGHCVIVVAEGAGQslKDADLDLGTDasgnkklwdigvyLKDEITKYLKKKKPEHTVKYIDpsymiRAVPANAA 376

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24652337  311 DRILACRMgaeATLALMEATKDSVPVVISLDGNQAVRVPLmecvertqavaKAMAEKrWADAVKLRGRSFERNLE 385
Cdd:PTZ00286 377 DAKFCTQL---AQNAVHGAMAGFTGFIIGHVHNNYVMIPI-----------KEMSGN-YRRRVNPEGRLWQRMLA 436
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
408-698 1.84e-24

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 105.92  E-value: 1.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  408 EGYRLAVMHIGAPACGMNAAVRSFVRNAIYR-GDVVYGINDGVEGLIAG--NVRELGWSDVSGWVGQGGAYLGTKRT--- 481
Cdd:PRK14071   3 EKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNKgdp 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  482 ----LPEGKFK----EIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDnypqfcIPIVVIPSTISNNVPGTEFSLGCDT 553
Cdd:PRK14071  83 fafpMPDGSLRdrsqEIIDGYHSLGLDALIGIGGDGSLAILRRLAQQGG------INLVGIPKTIDNDVGATEVSIGFDT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  554 GLNEITEICDRIRQSAqGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLqqdVYHMASKMAEGVSRGL 633
Cdd:PRK14071 157 AVNIATEALDRLHFTA-ASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENV---CKKIRERQEEGKNFCL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  634 ILRNE--KASENYSTDFIYRL----------YSEEGKGLFT---CRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAA 698
Cdd:PRK14071 233 VVVSEavRTEEGEQVTKTQALgedryggigqYLAEQIAERTgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
21-268 2.95e-23

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 103.41  E-value: 2.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   21 AVFTSGGDSQGMNAAVRACVRMAIYL-GCK-VYFIREGYQGMV-DGGDCIQEANWASVSSIIHRGGTIIGSAR-CQDFRE 96
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIVLELHHHyGVRrILGIRYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSRgPQDPEE 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   97 rqgrlkAANNLIQRGITNLVVIGGDGSLTGANLFRQEwsslldelvknktiTTEQQEKFNVlhiVGLVGSIDNDFCGTDM 176
Cdd:PRK06830 164 ------IVDTLERMNINILFVIGGDGTLRGASAIAEE--------------IERRGLKISV---IGIPKTIDNDINFIQK 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  177 TIGTDTALHRIIEAIDAISSTAYSHQRTF-IMEVMGRHCGYLALVGGLAC-EADFIFIPEMPPKVDWPDRLCSQLaQERS 254
Cdd:PRK06830 221 SFGFETAVEKATEAIRCAHVEANGAPNGIgLVKLMGRHSGFIAAYAALASkDVNFVLIPEVPFDLEGPNGLLAAL-EKRL 299

                        250
                 ....*....|....
gi 24652337  255 AGQRLNIVIVAEGA 268
Cdd:PRK06830 300 AERGHAVIVVAEGA 313
PLN02884 PLN02884
6-phosphofructokinase
 21-322 3.71e-15

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 78.31  E-value: 3.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   21 AVFTSGGDSQGMNAAVRACV-RMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARcqdfrerqG 99
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------G 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  100 RLKAA---NNLIQRGITNLVVIGGDGSLTGANLFRQEWsslldelvknktitteQQEKFNVLhIVGLVGSIDNDFCGTDM 176
Cdd:PLN02884 129 GAKTSdivDSIEARGINMLFVLGGNGTHAGANAIHNEC----------------RKRKMKVS-VVGVPKTIDNDILLMDK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  177 TIGTDTALHriiEAIDAISStAYSHQRTF-----IMEVMGRHCGYLALVGGLAC-EADFIFIPEMPPKVDWPDRLCSQLa 250
Cdd:PLN02884 192 TFGFDTAVE---EAQRAINS-AYIEAHSAyhgigLVKLMGRSSGFIAMHASLASgQVDICLIPEVPFTLDGPNGVLRHL- 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  251 QERSAGQRLNIVIVAEGA----------MDREGHPITAEDVKKVIDERLKHDARITVLGHVQ--------RGGNPSAFDR 312
Cdd:PLN02884 267 EHLIETKGSAVVCVAEGAgqdllqktnaTDASGNPVLGDIGVHLQQEIKKHFKDIGVPADVKyidptymiRACRANASDA 346

                        330
                 ....*....|
gi 24652337  313 ILACRMGAEA 322
Cdd:PLN02884 347 ILCTVLGQNA 356
PLN02564 PLN02564
6-phosphofructokinase
 21-268 1.53e-14

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 77.10  E-value: 1.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   21 AVFTSGGDSQGMNAAVR--ACVRMAIYLGCKVYFIREGYQGMVDGGDCiqEANWASVSSIIHRGGTIIGSARC-QDFRer 97
Cdd:PLN02564  91 CIVTCGGLCPGLNTVIReiVCGLSYMYGVTRILGIDGGYRGFYSRNTI--PLTPKVVNDIHKRGGTILGTSRGgHDTS-- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   98 qgrlKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWsslldelvknktitteQQEKFNVLhIVGLVGSIDNDFCGTDMT 177
Cdd:PLN02564 167 ----KIVDSIQDRGINQVYIIGGDGTQKGASVIYEEI----------------RRRGLKVA-VAGIPKTIDNDIPVIDKS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  178 IGTDTALHRIIEAIDAISSTAYS-HQRTFIMEVMGRHCGYLALVGGLAC-EADFIFIPEMPPKVDWPDRLCSQLAQERSA 255
Cdd:PLN02564 226 FGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPFYLEGKGGLFEFIEKRLKE 305

                        250
                 ....*....|...
gi 24652337  256 GQRLNIViVAEGA 268
Cdd:PLN02564 306 NGHMVIV-VAEGA 317
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 423-590 5.34e-13

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 72.00  E-value: 5.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  423 GMNAAVRSFVRNAIYRGDV--VYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRtlpeGKF--KEIAARLKEFK 498
Cdd:PTZ00286 101 GLNVVIRELVMNLINNYGVktIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSR----GGFdpKVMVDTLIRHG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  499 IQGLLIIGGFESYHAAGQIADQ--RDNYPqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRV 576
Cdd:PTZ00286 177 INILFTLGGDGTHRGALAIYKElrRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGV 253

                        170
                 ....*....|....
gi 24652337  577 FVIETMGGYCGYLA 590
Cdd:PTZ00286 254 GIVKLMGRDSGFIA 267
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
158-338 2.43e-12

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 69.50  E-value: 2.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  158 LHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAI--DAISSTAY-SHQRTFIMEVMGRHCGYLALVGGLACE-----ADF 229
Cdd:PRK14072 133 IRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleAALDVAAMaNTSKVFILEVMGRHAGWLAAAAALAKQnpddaPHL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  230 IFIPEMPPKVDwpdrlcSQLAQERSAGQRLN--IVIVAEGAMDREGHPI----TAED-------------VKKVIDERLK 290
Cdd:PRK14072 213 IYLPERPFDEE------KFLADVRAIVKRYGycVVVVSEGIRDADGKFIaeagLAEDafghaqlggvapvLANLIKEKLG 286

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 24652337  291 HDARITVLGHVQR--GGNPSAFDRILACRMGAEATLALMeATKDSVPVVI 338
Cdd:PRK14072 287 KKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYAL-AGKNGVMPAI 335
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 18-324 1.17e-09

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 61.18  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   18 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFI--REGYQGMVdGGDCIQ-----EANwasvSSIIHR-GGTIIGSA 89
Cdd:PRK06555   4 KKVALLTAGGLAPCLSSAVGGLIERYTEIAPEVEIIayRSGYQGLL-LGDSIEitpavRAN----AGLLHRyGGSPIGNS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   90 R--------CQD---FRERQGRLK-AANNLIQRGITNLVVIGGDGSLTGAnlfrqewSSLLDELVKNKTITTeqqekfnv 157
Cdd:PRK06555  79 RvkltnvadCVKrglVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENGYDLT-------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  158 lhIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIM-EVMGRHCGYLA---------------LVG 221
Cdd:PRK06555 144 --VVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTaatarayrewldrqeYVP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  222 GLACEADF-----IFIPEMPPKVDwpdrlcsqlaqerSAGQRLNIVivaegaMDREG------------HPITAEDVKKv 284
Cdd:PRK06555 222 GFGLSAERwdihaVYLPEMAFDLE-------------AEAERLKAV------MDEVGnvniflsegaglDAIVAEMEAA- 281

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 24652337  285 iDERLKHDAritvLGHVQRGG-NPSA-FDRILACRMGAEATL 324
Cdd:PRK06555 282 -GEEVKRDA----FGHVKLDTiNPGAwFAKQFAELLGAEKVM 318
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
423-591 1.00e-06

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 51.79  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  423 GMNAAVRSFVRNAIYRGDV--VYGINDGVEGLIAG---NVRELGWSDVSGWVGQGGAYLGTKR--TLPEgkfkEIAARLK 495
Cdd:PRK06830  94 GLNDVIRAIVLELHHHYGVrrILGIRYGYQGLIPRyghDPVELTPEVVADIHEFGGTILGSSRgpQDPE----EIVDTLE 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  496 EFKIQGLLIIGGFESYHAAGQIAD--QRDNYPqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTK 573
Cdd:PRK06830 170 RMNINILFVIGGDGTLRGASAIAEeiERRGLK---ISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCAHVEANGAP 246

                        170
                 ....*....|....*...
gi 24652337  574 RRVFVIETMGGYCGYLAT 591
Cdd:PRK06830 247 NGIGLVKLMGRHSGFIAA 264
PLN02564 PLN02564
6-phosphofructokinase
 423-590 7.35e-06

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 49.36  E-value: 7.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  423 GMNAAVRSFV--RNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKR----TlpegkfKEIAARLKE 496
Cdd:PLN02564 101 GLNTVIREIVcgLSYMYGVTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSRgghdT------SKIVDSIQD 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  497 FKIQGLLIIGGFESYHAAGQIAD--QRDNYPqfcIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKR 574
Cdd:PLN02564 175 RGINQVYIIGGDGTQKGASVIYEeiRRRGLK---VAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVEN 251

                        170
                 ....*....|....*.
gi 24652337  575 RVFVIETMGGYCGYLA 590
Cdd:PLN02564 252 GIGLVKLMGRYSGFIA 267
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 20-270 2.91e-05

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 47.73  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    20 LAVFTSGGDSQGMNAAVRAcvrmaIYLGCKVYFIREGYQGMVDGGDCIQEANWASVS-SIIHR-----GGTIIGSARCQd 93
Cdd:PTZ00287  180 IGIILSGGPAPGGHNVISG-----IYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITdSLMNRfrnlgGFNMLWSGRGK- 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    94 FRERQGRLKAANNLIQRGITNLVVIGGDGSLTGAnlfrqewsSLLDELVKNKTITteqqekfnvLHIVGLVGSIDNDFC- 172
Cdd:PTZ00287  254 VRNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKs 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   173 -GTDMTIGTDTALHRIIEAIDAISSTAYS-HQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKV-----DWPDRL 245
Cdd:PTZ00287  317 eAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKEnlslkDIVSNI 396

                         250       260
                  ....*....|....*....|....*
gi 24652337   246 CSQLAQERSAGQRLNIVIVAEGAMD 270
Cdd:PTZ00287  397 VNTILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 75-270 3.86e-05

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 47.28  E-value: 3.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337    75 VSSIIHRGG-TIIGSARCQDFRERQgrLKAANNLIQR-GITNLVVIGGDGSLTGANL----FRQEWSSLLdelvknktit 148
Cdd:PTZ00468  160 INGILNQGGfNIICSGRHKIETEEQ--MRASLEICEKlKLHGLVVIGGDDSNTNAAVlaeyFKRNSSSTV---------- 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   149 teqqekfnvlhIVGLVGSIDNDFCG--TDMTIGTDTALHRIIEAIDAI-SSTAYSHQRTFIMEVMGRHCGYLALVGGLAC 225
Cdd:PTZ00468  228 -----------VVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSImDAIKTEGYGYYFVRLMGRSASHITLECGLQT 296

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 24652337   226 EADFIFIPEMPPKVDWP-----DRLCSQLAQERSAGQRLNIVIVAEGAMD 270
Cdd:PTZ00468  297 RANMILIGEEIKEENRSlmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 82-270 4.99e-05

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 46.79  E-value: 4.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  82 GGTIIGSARCQDFRERQGRlKAANNLIQRGITNLVVIGGDGSLTGAnlfrqewsSLLDELVKNKTITTEqqekfnvlhIV 161
Cdd:cd00765 138 GFDMICSGRTKIETEDQFK-QAEETAKKLDLDALVVIGGDDSNTNA--------ALLAENFRSKGLKTR---------VI 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337 162 GLVGSIDNDFCGTDMTI--GTDTALHRIIE-----AIDAISSTAYSHqrtFImEVMGRHCGYLALVGGLACEADFIFIPE 234
Cdd:cd00765 200 GVPKTIDGDLKNKEIETsfGFDTATKIYSElignvMRDARSTGKYWH---FV-KLMGRSASHIALECALKTHPNICIISE 275

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24652337 235 MPPK-----VDWPDRLCSQLAQERSAGQRLNIVIVAEGAMD 270
Cdd:cd00765 276 EVSAqkqtlKNITDYMVDVICKRAELGYNFGVVLVPEGLIE 316
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 411-583 5.14e-04

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 43.37  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  411 RLAVMHIGAPA-------CGMNAAVRSFVRNAiyrgdVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGG-AYLGTKRTL 482
Cdd:PRK07085  72 KVGVILSGGQApgghnviAGLFDGLKKLNPDS-----KLFGFIGGPLGLLNGKYIEITEEVIDEYRNTGGfDMIGSGRTK 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  483 PEGK--FKEIAARLKEFKIQGLLIIGGFESYHAAGQIAD--QRDNYPqfcIPIVVIPSTISNNVPGT--EFSLGCDTGLN 556
Cdd:PRK07085 147 IETEeqKEACLETVKKLKLDGLVIIGGDDSNTNAAILAEyfAKHGCK---TQVIGVPKTIDGDLKNEfiETSFGFDTATK 223

                        170       180
                 ....*....|....*....|....*..
gi 24652337  557 EITEICDRIRQSAQGTKRRVFVIETMG 583
Cdd:PRK07085 224 TYSEMIGNISRDALSAKKYWHFIKLMG 250
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 85-267 8.46e-04

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 42.60  E-value: 8.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   85 IIGSARCQDFRERQgRLKAANNLIQRGITNLVVIGGDGSLTGAnlfrqewsSLLDELVKNKTITTEqqekfnvlhIVGLV 164
Cdd:PRK07085 139 MIGSGRTKIETEEQ-KEACLETVKKLKLDGLVIIGGDDSNTNA--------AILAEYFAKHGCKTQ---------VIGVP 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337  165 GSIDNDFCGT--DMTIGTDTALHRIIEAI-----DAISSTAYSHqrtFImEVMGRHCGYLALVGGLACEADFIFIPE--- 234
Cdd:PRK07085 201 KTIDGDLKNEfiETSFGFDTATKTYSEMIgnisrDALSAKKYWH---FI-KLMGRSASHIALECALQTHPNICLISEeva 276

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 24652337  235 ---MPPKvDWPDRLCSQLAQERSAGQRLNIVIVAEG 267
Cdd:PRK07085 277 ekkMSLQ-DIVHYIASVIADRAAKGKNYGVILIPEG 311
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 442-583 8.89e-03

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 39.57  E-value: 8.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652337   442 VYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYL---GTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIA 518
Cdd:PTZ00468  137 LFGFLGGPEGVYSERYRELTEDDINGILNQGGFNIicsGRHKIETEEQMRASLEICEKLKLHGLVVIGGDDSNTNAAVLA 216

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24652337   519 DQrdnYPQFCIPIVVI--PSTISNNVPG--TEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMG 583
Cdd:PTZ00468  217 EY---FKRNSSSTVVVgcPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGYGYYFVRLMG 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH