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Conserved domains on  [gi|665399984|ref|NP_724893|]
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gemini, isoform G [Drosophila melanogaster]

Protein Classification

SAM domain-containing protein; ACK family non-receptor tyrosine-protein kinase( domain architecture ID 10266807)

SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation| ACK (activated Cdc42-associated kinase) family non-receptor tyrosine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates; such as TNK1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CP2 super family cl04559
CP2 transcription factor; This family represents a conserved region in the CP2 transcription ...
 380-614 6.30e-70

CP2 transcription factor; This family represents a conserved region in the CP2 transcription factor family.


The actual alignment was detected with superfamily member pfam04516:

Pssm-ID: 461338  Cd Length: 214  Bit Score: 230.77  E-value: 6.30e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  380 AEDHKFQYILAAATSIATKNNEETLTYLNQGQSYEIKLKKIG--DLSLYRDKILKSVIKICFHERRLQFMEREQMQQWQQ 457
Cdd:pfam04516  16 TENFRFHYTLEAPTAMIKKVNEIPMTYLNKGQAYSISLIDTGmnKCSVLPGSKLRSVVRVVFHERKLRVEELKCWQLWKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  458 SRPGE--RIIEVdvplSYGLCHVS----QPLSSGSLNTVEIFWDPLKEVGVYIKVNCISTEFTPKKhgGEKGVPFRLQIE 531
Cdd:pfam04516  96 GRPTAavRIVDP----LYGGYEEQkntqVNIESISFNAFSFTWNPTEECKIFIRVNCLSTDFSHSK--GVKGVPLRLQIK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  532 TYIENtnsatasgsggsnnsaiasgsgssgsaapaspertpsaGSNGKQAVHAAACQIKVFKLKGADRKHKQDREKIQKR 611
Cdd:pfam04516 170 TYSYG--------------------------------------PGSARPAAHRAYCQVKVFRDKGAERKLSNDVAKVKKR 211


                  ...
gi 665399984  612 PQS 614
Cdd:pfam04516 212 IGK 214
SAM_CP2-like cd09537
SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like ...
 726-792 1.31e-36

SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and some also have a C-terminal dimerization domain. CP2-like family of transcriptional factors includes three subgroups: LBP1, TFCP2, and LBP9. Members of this family are involved in transcriptional regulation from early development to terminal differentiation. They play a role in regulation of expression of P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in placenta, and alpha-globin in erythroid cells. They are required for proper maturation of the dust (epithelial component of tubular organs) of kidney and salivary gland. Human LBP1 is known to be induced by HIV type I infection in lymphocytes; it represses HIV transcription by preventing the binding of TFIID to the virus promoter. Additionally, it has been suggested that UBP1 (LBP1) regulator might be a member of a blood pressure controlling network. LBP1 protein isoforms are able to form dimers apparently via SAM domain since SAM deletion or mutation resulted in a loss of this ability.


:

Pssm-ID: 188936  Cd Length: 67  Bit Score: 131.71  E-value: 1.31e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665399984 726 TPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYAS 792
Cdd:cd09537    1 SPQQTTQWLRKNRFGAYLRTFSNFSGADLLRLTRDDLIQICGLADGIRLFNALHSRAIRPRLTLYVC 67
 
Name Accession Description Interval E-value
CP2 pfam04516
CP2 transcription factor; This family represents a conserved region in the CP2 transcription ...
 380-614 6.30e-70

CP2 transcription factor; This family represents a conserved region in the CP2 transcription factor family.


Pssm-ID: 461338  Cd Length: 214  Bit Score: 230.77  E-value: 6.30e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  380 AEDHKFQYILAAATSIATKNNEETLTYLNQGQSYEIKLKKIG--DLSLYRDKILKSVIKICFHERRLQFMEREQMQQWQQ 457
Cdd:pfam04516  16 TENFRFHYTLEAPTAMIKKVNEIPMTYLNKGQAYSISLIDTGmnKCSVLPGSKLRSVVRVVFHERKLRVEELKCWQLWKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  458 SRPGE--RIIEVdvplSYGLCHVS----QPLSSGSLNTVEIFWDPLKEVGVYIKVNCISTEFTPKKhgGEKGVPFRLQIE 531
Cdd:pfam04516  96 GRPTAavRIVDP----LYGGYEEQkntqVNIESISFNAFSFTWNPTEECKIFIRVNCLSTDFSHSK--GVKGVPLRLQIK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  532 TYIENtnsatasgsggsnnsaiasgsgssgsaapaspertpsaGSNGKQAVHAAACQIKVFKLKGADRKHKQDREKIQKR 611
Cdd:pfam04516 170 TYSYG--------------------------------------PGSARPAAHRAYCQVKVFRDKGAERKLSNDVAKVKKR 211


                  ...
gi 665399984  612 PQS 614
Cdd:pfam04516 212 IGK 214
SAM_CP2-like cd09537
SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like ...
 726-792 1.31e-36

SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and some also have a C-terminal dimerization domain. CP2-like family of transcriptional factors includes three subgroups: LBP1, TFCP2, and LBP9. Members of this family are involved in transcriptional regulation from early development to terminal differentiation. They play a role in regulation of expression of P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in placenta, and alpha-globin in erythroid cells. They are required for proper maturation of the dust (epithelial component of tubular organs) of kidney and salivary gland. Human LBP1 is known to be induced by HIV type I infection in lymphocytes; it represses HIV transcription by preventing the binding of TFIID to the virus promoter. Additionally, it has been suggested that UBP1 (LBP1) regulator might be a member of a blood pressure controlling network. LBP1 protein isoforms are able to form dimers apparently via SAM domain since SAM deletion or mutation resulted in a loss of this ability.


Pssm-ID: 188936  Cd Length: 67  Bit Score: 131.71  E-value: 1.31e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665399984 726 TPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYAS 792
Cdd:cd09537    1 SPQQTTQWLRKNRFGAYLRTFSNFSGADLLRLTRDDLIQICGLADGIRLFNALHSRAIRPRLTLYVC 67
SAM_3 pfam18016
SAM domain (Sterile alpha motif);
716-779 2.12e-23

SAM domain (Sterile alpha motif);


Pssm-ID: 436214  Cd Length: 65  Bit Score: 94.25  E-value: 2.12e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665399984  716 DYSQNIMPESTPSQVTQWLTNHRLTA-YLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILR 779
Cdd:pfam18016   1 TDSINITPKSTPEEVQAWLTAKGFSKkTVKSLGTLSGAQLFSLSKEELKQICGPAEGIRLYSQLL 65
 
Name Accession Description Interval E-value
CP2 pfam04516
CP2 transcription factor; This family represents a conserved region in the CP2 transcription ...
 380-614 6.30e-70

CP2 transcription factor; This family represents a conserved region in the CP2 transcription factor family.


Pssm-ID: 461338  Cd Length: 214  Bit Score: 230.77  E-value: 6.30e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  380 AEDHKFQYILAAATSIATKNNEETLTYLNQGQSYEIKLKKIG--DLSLYRDKILKSVIKICFHERRLQFMEREQMQQWQQ 457
Cdd:pfam04516  16 TENFRFHYTLEAPTAMIKKVNEIPMTYLNKGQAYSISLIDTGmnKCSVLPGSKLRSVVRVVFHERKLRVEELKCWQLWKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  458 SRPGE--RIIEVdvplSYGLCHVS----QPLSSGSLNTVEIFWDPLKEVGVYIKVNCISTEFTPKKhgGEKGVPFRLQIE 531
Cdd:pfam04516  96 GRPTAavRIVDP----LYGGYEEQkntqVNIESISFNAFSFTWNPTEECKIFIRVNCLSTDFSHSK--GVKGVPLRLQIK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399984  532 TYIENtnsatasgsggsnnsaiasgsgssgsaapaspertpsaGSNGKQAVHAAACQIKVFKLKGADRKHKQDREKIQKR 611
Cdd:pfam04516 170 TYSYG--------------------------------------PGSARPAAHRAYCQVKVFRDKGAERKLSNDVAKVKKR 211


                  ...
gi 665399984  612 PQS 614
Cdd:pfam04516 212 IGK 214
SAM_CP2-like cd09537
SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like ...
 726-792 1.31e-36

SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and some also have a C-terminal dimerization domain. CP2-like family of transcriptional factors includes three subgroups: LBP1, TFCP2, and LBP9. Members of this family are involved in transcriptional regulation from early development to terminal differentiation. They play a role in regulation of expression of P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in placenta, and alpha-globin in erythroid cells. They are required for proper maturation of the dust (epithelial component of tubular organs) of kidney and salivary gland. Human LBP1 is known to be induced by HIV type I infection in lymphocytes; it represses HIV transcription by preventing the binding of TFIID to the virus promoter. Additionally, it has been suggested that UBP1 (LBP1) regulator might be a member of a blood pressure controlling network. LBP1 protein isoforms are able to form dimers apparently via SAM domain since SAM deletion or mutation resulted in a loss of this ability.


Pssm-ID: 188936  Cd Length: 67  Bit Score: 131.71  E-value: 1.31e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665399984 726 TPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYAS 792
Cdd:cd09537    1 SPQQTTQWLRKNRFGAYLRTFSNFSGADLLRLTRDDLIQICGLADGIRLFNALHSRAIRPRLTLYVC 67
SAM_3 pfam18016
SAM domain (Sterile alpha motif);
716-779 2.12e-23

SAM domain (Sterile alpha motif);


Pssm-ID: 436214  Cd Length: 65  Bit Score: 94.25  E-value: 2.12e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665399984  716 DYSQNIMPESTPSQVTQWLTNHRLTA-YLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILR 779
Cdd:pfam18016   1 TDSINITPKSTPEEVQAWLTAKGFSKkTVKSLGTLSGAQLFSLSKEELKQICGPAEGIRLYSQLL 65
SAM_LBP1 cd09588
SAM domain of LBP1 (UBP1) transcription factors; SAM (sterile alpha motif) domain of LBP1 ...
 726-792 5.50e-21

SAM domain of LBP1 (UBP1) transcription factors; SAM (sterile alpha motif) domain of LBP1 (also known as UBP1) transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and some also have a C-terminal dimerization domain. They are involved in transcriptional regulation from early development to terminal differentiation. In particular, they regulate alpha-globin in erythroid cells and P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in human placenta. Human LBP1 is known to be induced by HIV type I infection in lymphocytes; it represses HIV transcription by preventing the binding of TFIID to the virus promoter. Additionally, it has been suggested that UBP1 (LPB1) regulator might be a member of a blood pressure controlling network. LBP1 protein isoforms are able to form dimers, apparently via SAM domain since SAM deletion or mutation resulted in a loss of this ability.


Pssm-ID: 188987  Cd Length: 67  Bit Score: 87.35  E-value: 5.50e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665399984 726 TPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYAS 792
Cdd:cd09588    1 TIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTREDLVQICGAADGIRLYNALKSRSVRPRLTIYVC 67
SAM_LBP9 cd09590
SAM domain of LBP9 transcriptional factors; SAM (sterile alpha motif) domain of LBP9 (also ...
 730-792 3.61e-20

SAM domain of LBP9 transcriptional factors; SAM (sterile alpha motif) domain of LBP9 (also known as TFCP2L1 or CRTR-1 (CP2-Related Transcriptional Repressor-1)) transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and a C-terminal dimerization domain. They are involved in transcriptional regulation from early development to terminal differentiation. In particular, they are required for proper maturation of the dust (epithelial component of tubular organs) of kidney and salivary gland as well as for regulation of P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in human placenta.


Pssm-ID: 188989  Cd Length: 67  Bit Score: 84.95  E-value: 3.61e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665399984 730 VTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYAS 792
Cdd:cd09590    5 AQQWLHRNRFSQFCRLFSSFSGADLLKMSRDDFIQICGPADGIRLFNAIKGRNVRPRLTIYVC 67
SAM_TFCP2 cd09589
SAM domain of TFCP2 transcription factors; SAM (sterile alpha motif) domain of TFCP2 ...
 726-790 4.68e-20

SAM domain of TFCP2 transcription factors; SAM (sterile alpha motif) domain of TFCP2 transcription factors is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and a C-terminal dimerization domain. They are involved in transcriptional regulation from early development to terminal differentiation. In particular, they regulate expression of erythroid cell-specific alpha-globin, fibrinogen, and sex-determining gene SRY as well as lens alpha-crystallin. TFCP2 regulators can interact with NF-E4 proteins forming heteromeric stage selector protein complex (SSP). This complex is able to bind stage selector element (SSE) and regulate embryonic globin expression in fetal-erythroid cells.


Pssm-ID: 188988  Cd Length: 67  Bit Score: 84.65  E-value: 4.68e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665399984 726 TPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLY 790
Cdd:cd09589    1 TPQEAQQWLHRNRFSTFSRLFTNFSGADLLKLTREDVIQICGPADGIRLFNALKGRMVRPRLTIY 65
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 729-780 9.08e-04

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 37.99  E-value: 9.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 665399984 729 QVTQWLTNHRLTAYLSTFAQ--FSGADIMRMSKEDLIQICGLADGIRMfNILRA 780
Cdd:cd09487    1 DVAEWLESLGLEQYADLFRKneIDGDALLLLTDEDLKELGITSPGHRK-KILRA 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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