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Conserved domains on  [gi|24653374|ref|NP_725293|]
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uncharacterized protein Dmel_CG30060 [Drosophila melanogaster]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 34-177 2.30e-43

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 142.13  E-value: 2.30e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374  34 KVISVLYPCDIDIKPGIMVVINETLKQPIIRFKA--DPEHYHTLMMVDLDVPPDNN---TEWLIWMVGNIPGCD-----V 103
Cdd:cd00866   1 VDLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSedPPDKLYTLVMVDPDAPSRDDpkfREWLHWLVTNIPGSDtttglV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653374 104 AMGQTLVAYDNRRTIHGSNIHRIVFLAFKQYLELDFDETFVPEGEEKGRGTFNCHNFARKYALGNPMAANFYLV 177
Cdd:cd00866  81 SKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 34-177 2.30e-43

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 142.13  E-value: 2.30e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374  34 KVISVLYPCDIDIKPGIMVVINETLKQPIIRFKA--DPEHYHTLMMVDLDVPPDNN---TEWLIWMVGNIPGCD-----V 103
Cdd:cd00866   1 VDLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSedPPDKLYTLVMVDPDAPSRDDpkfREWLHWLVTNIPGSDtttglV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653374 104 AMGQTLVAYDNRRTIHGSNIHRIVFLAFKQYLELDFDETFVPEGEEKGRGTFNCHNFARKYALGNPMAANFYLV 177
Cdd:cd00866  81 SKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 45-175 3.45e-16

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 72.92  E-value: 3.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374   45 DIKPGiMVVinetlKQPIIRFKA-DPEHYHTLMMVDLDVPPDNNT---EWLIWMVGNIPGCDVA-MGQTLVAYDNRRTIH 119
Cdd:PLN00169  42 ELKPS-QVV-----NQPRVDIGGeDLRTFYTLVMVDPDAPSPSNPnlrEYLHWLVTDIPATTGAtFGQEVVCYESPRPTA 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24653374  120 GsnIHRIVFLAFKQyleLDFDETFVPegeeKGRGTFNCHNFARKYALGNPMAANFY 175
Cdd:PLN00169 116 G--IHRFVFVLFRQ---LGRQTVYAP----GWRQNFNTRDFAELYNLGSPVAAVYF 162
PBP pfam01161
Phosphatidylethanolamine-binding protein;
60-174 1.89e-04

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 40.02  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374    60 QPIIRFKADPE---HYhTLMMVDLDVPPDNNTEWLIWMVGNIPgcdvAMGQTLVAYDNRRTIHGSN-------------- 122
Cdd:pfam01161  14 SPPLAWSGAPAgtkSF-ALVMIDPDAPKVGGSGWLHWVVTNIP----ATVTELPEGAPAGAVQGLNdfggagyggpcppa 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24653374   123 ---IHRIVFLAFKqyleLDFDETFVPEGEEKGRG--TFNCHNFARKyalgnPMAANF 174
Cdd:pfam01161  89 gdgPHRYVFTLYA----LDVPLLDRNWGFTKAELgvAFAGHVLALA-----VLAGNY 136
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 34-177 2.30e-43

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 142.13  E-value: 2.30e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374  34 KVISVLYPCDIDIKPGIMVVINETLKQPIIRFKA--DPEHYHTLMMVDLDVPPDNN---TEWLIWMVGNIPGCD-----V 103
Cdd:cd00866   1 VDLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSedPPDKLYTLVMVDPDAPSRDDpkfREWLHWLVTNIPGSDtttglV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653374 104 AMGQTLVAYDNRRTIHGSNIHRIVFLAFKQYLELDFDETFVPEGEEKGRGTFNCHNFARKYALGNPMAANFYLV 177
Cdd:cd00866  81 SKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 45-175 3.45e-16

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 72.92  E-value: 3.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374   45 DIKPGiMVVinetlKQPIIRFKA-DPEHYHTLMMVDLDVPPDNNT---EWLIWMVGNIPGCDVA-MGQTLVAYDNRRTIH 119
Cdd:PLN00169  42 ELKPS-QVV-----NQPRVDIGGeDLRTFYTLVMVDPDAPSPSNPnlrEYLHWLVTDIPATTGAtFGQEVVCYESPRPTA 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24653374  120 GsnIHRIVFLAFKQyleLDFDETFVPegeeKGRGTFNCHNFARKYALGNPMAANFY 175
Cdd:PLN00169 116 G--IHRFVFVLFRQ---LGRQTVYAP----GWRQNFNTRDFAELYNLGSPVAAVYF 162
PBP pfam01161
Phosphatidylethanolamine-binding protein;
60-174 1.89e-04

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 40.02  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653374    60 QPIIRFKADPE---HYhTLMMVDLDVPPDNNTEWLIWMVGNIPgcdvAMGQTLVAYDNRRTIHGSN-------------- 122
Cdd:pfam01161  14 SPPLAWSGAPAgtkSF-ALVMIDPDAPKVGGSGWLHWVVTNIP----ATVTELPEGAPAGAVQGLNdfggagyggpcppa 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24653374   123 ---IHRIVFLAFKqyleLDFDETFVPEGEEKGRG--TFNCHNFARKyalgnPMAANF 174
Cdd:pfam01161  89 gdgPHRYVFTLYA----LDVPLLDRNWGFTKAELgvAFAGHVLALA-----VLAGNY 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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