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Conserved domains on  [gi|24653578|ref|NP_725367|]
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uncharacterized protein Dmel_CG8468, isoform A [Drosophila melanogaster]

Protein Classification

MCT family MFS transporter( domain architecture ID 13023985)

monocarboxylate transporter (MCT) family major facilitator superfamily (MFS) transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418|22131303|12739169|23177990
SCOP:  3000310
TCDB:  2.A.1.13

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 49-225 3.65e-66

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 222.04  E-value: 3.65e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRYTL 207
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLdNYGWRGAL 160

                       170
                ....*....|....*...
gi 24653578 208 AIQGIIVLSCALFGLAFR 225
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR 178
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 477-658 1.17e-53

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17352:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 188.15  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALT 556
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 557 AGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGS 636
Cdd:cd17352 259 ILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGD 338

                       170       180
                ....*....|....*....|..
gi 24653578 637 YNAAFYFAGGLILLSAFLCYPL 658
Cdd:cd17352 339 YDAAFYFCGACLLLSGVLLFLL 360
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 49-225 3.65e-66

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 222.04  E-value: 3.65e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRYTL 207
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLdNYGWRGAL 160

                       170
                ....*....|....*...
gi 24653578 208 AIQGIIVLSCALFGLAFR 225
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR 178
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 477-658 1.17e-53

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 188.15  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALT 556
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 557 AGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGS 636
Cdd:cd17352 259 ILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGD 338

                       170       180
                ....*....|....*....|..
gi 24653578 637 YNAAFYFAGGLILLSAFLCYPL 658
Cdd:cd17352 339 YDAAFYFCGACLLLSGVLLFLL 360
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 43-229 2.75e-36

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 142.19  E-value: 2.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    43 PPDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITG 122
Cdd:TIGR00892  11 PPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   123 AIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS- 201
Cdd:TIGR00892  91 GLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESf 170

                         170       180
                  ....*....|....*....|....*...
gi 24653578   202 GWRYTLAIQGIIVLSCALFGLAFRPIQP 229
Cdd:TIGR00892 171 GWRGSFLILGGLLLHCCVCGALMRPVGP 198
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 439-652 1.80e-23

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 104.05  E-value: 1.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   439 MSVTRLPTKQDMLED---RQKGCRICPEAVRRtlstMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDE 515
Cdd:TIGR00892 200 QRVSKSKSKEGLPPDgstKKLSKKSTAEKINR----FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   516 QAAYGVLSGIGVVNTFARIVCGSLSSFPAVKP--LWLNNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRS 593
Cdd:TIGR00892 276 YEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPhvQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLF 355

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653578   594 LIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAGGLILLSA 652
Cdd:TIGR00892 356 EVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAG 414
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
49-224 2.31e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 96.87  E-value: 2.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:COG2223   3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEyLFLIYGVLGGIGFCMVYIPAVVIIGFYFEK-WRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYT 206
Cdd:COG2223  83 GLLLLALAVSYW-LLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNA 161

                       170
                ....*....|....*...
gi 24653578 207 LAIQGIIVLSCALFGLAF 224
Cdd:COG2223 162 FLILGILLLVVAVLAWLF 179
MFS_1 pfam07690
Major Facilitator Superfamily;
52-226 2.29e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.93  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    52 VMVASFLCCTVIDGIvfcSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFG 131
Cdd:pfam07690   1 LFLAAFLAALGRSLL---GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   132 LSYFATSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKW-RALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAI 209
Cdd:pfam07690  78 LLLFASSL-WLLLVLRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLI 156

                         170
                  ....*....|....*..
gi 24653578   210 QGIIVLSCALFGLAFRP 226
Cdd:pfam07690 157 LAILSLLAAVLLLLPRP 173
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
462-668 7.77e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 73.76  E-value: 7.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 462 PEAVRRTLSTMLDttLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAK-AAGMDEQAAYGVLSGIGVVNTFARIVCGSLS 540
Cdd:COG2223 188 AAAAKASLRDQLE--ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLS 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 541 S-FPAVKPLWLNnFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAvELIGLEKLTNAYGFLMLFQGLA 619
Cdd:COG2223 266 DrIGGRRVLLIV-FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLG 343

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 24653578 620 ATFGSPIAGGLYVMTGSYNAAFYFAGGLILLSAFlcypLTWVSRWEERR 668
Cdd:COG2223 344 GFLGPLLFGALLDATGSYTAAFLVFAVLALVALV----LTLLLYRRPRR 388
MFS_1 pfam07690
Major Facilitator Superfamily;
486-656 1.29e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.04  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   486 LAFSGFLTMMGFFVPFTFLV-DRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLnnFALTAGGIATIC 564
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   565 SGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGsYNAAFYFA 644
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170
                  ....*....|..
gi 24653578   645 GGLILLSAFLCY 656
Cdd:pfam07690 158 AILSLLAAVLLL 169
PRK03699 PRK03699
putative transporter; Provisional
 56-248 4.52e-03

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 39.91  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   56 SFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLmAGPFVSAM-ANRFGFRPVTITGAIFAAIC----- 129
Cdd:PRK03699  12 SFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGIL-ISIFLNAWlMEIIPLKRQLIFGFALMILAvaglm 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  130 FGLSYFATSVeYLFLIyGVLGGIGFCmvyIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSG--WRYTL 207
Cdd:PRK03699  91 FSHSLALFSI-AMFVL-GVVSGITMS---IGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSieWYWVY 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 24653578  208 AIQGIIVLscALFGLAFRPIQPITLSVTNEEGDEQEKKKLN 248
Cdd:PRK03699 166 ACIGLVYV--AIFILTLFSEFPALGKHAPKADKPVAKEKWG 204
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 49-225 3.65e-66

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 222.04  E-value: 3.65e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRYTL 207
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLdNYGWRGAL 160

                       170
                ....*....|....*...
gi 24653578 208 AIQGIIVLSCALFGLAFR 225
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR 178
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 477-658 1.17e-53

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 188.15  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALT 556
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 557 AGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGS 636
Cdd:cd17352 259 ILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGD 338

                       170       180
                ....*....|....*....|..
gi 24653578 637 YNAAFYFAGGLILLSAFLCYPL 658
Cdd:cd17352 339 YDAAFYFCGACLLLSGVLLFLL 360
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 43-229 2.75e-36

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 142.19  E-value: 2.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    43 PPDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITG 122
Cdd:TIGR00892  11 PPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   123 AIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS- 201
Cdd:TIGR00892  91 GLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESf 170

                         170       180
                  ....*....|....*....|....*...
gi 24653578   202 GWRYTLAIQGIIVLSCALFGLAFRPIQP 229
Cdd:TIGR00892 171 GWRGSFLILGGLLLHCCVCGALMRPVGP 198
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 49-225 2.11e-30

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 123.02  E-value: 2.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17429   1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTL 207
Cdd:cd17429  81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEfGWRNAM 160

                       170
                ....*....|....*...
gi 24653578 208 AIQGIIVLSCALFGLAFR 225
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR 178
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 50-227 1.03e-26

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 112.49  E-value: 1.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17423   2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLA 208
Cdd:cd17423  82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTyAWRGALL 161

                       170
                ....*....|....*....
gi 24653578 209 IQGIIVLSCALFGLAFRPI 227
Cdd:cd17423 162 LLSALSLHLVPCGALLRPL 180
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 50-225 1.52e-25

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 108.74  E-value: 1.52e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17424   2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRYTLA 208
Cdd:cd17424  82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIeQFSWRGALL 161

                       170
                ....*....|....*..
gi 24653578 209 IQGIIVLSCALFGLAFR 225
Cdd:cd17424 162 ILGGFVLNLCVCGALMR 178
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 50-228 7.41e-25

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 106.76  E-value: 7.41e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17422   2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLA 208
Cdd:cd17422  82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESiGWRYCLL 161

                       170       180
                ....*....|....*....|
gi 24653578 209 IQGIIVLSCALFGLAFRPIQ 228
Cdd:cd17422 162 VVGALQLNIVVCGALLRVLK 181
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 49-227 8.97e-25

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 106.74  E-value: 8.97e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVAsflcCTVIDGIVF----CSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAI 124
Cdd:cd17430   1 GWAVLFG----CFVITGFSYafpkAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 125 FAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGW 203
Cdd:cd17430  77 LASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLeEYGW 156

                       170       180
                ....*....|....*....|....
gi 24653578 204 RYTLAIQGIIVLSCALFGLAFRPI 227
Cdd:cd17430 157 RGGFLILGGLLLNCCTCGAVMRPL 180
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 439-652 1.80e-23

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 104.05  E-value: 1.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   439 MSVTRLPTKQDMLED---RQKGCRICPEAVRRtlstMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDE 515
Cdd:TIGR00892 200 QRVSKSKSKEGLPPDgstKKLSKKSTAEKINR----FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   516 QAAYGVLSGIGVVNTFARIVCGSLSSFPAVKP--LWLNNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRS 593
Cdd:TIGR00892 276 YEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPhvQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLF 355

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653578   594 LIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAGGLILLSA 652
Cdd:TIGR00892 356 EVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAG 414
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 49-229 9.79e-23

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 101.07  E-value: 9.79e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFG-------VSKAyvAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTIT 121
Cdd:cd17420   1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTklgdpeaSFKA--AWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 122 GAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS 201
Cdd:cd17420  79 GAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDS 158

                       170       180
                ....*....|....*....|....*....
gi 24653578 202 -GWRYTLAIQGIIVLSCALFGLAFRPIQP 229
Cdd:cd17420 159 yGLEGTLRVLSLFMFVLILCSFTYRPLHP 187
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 49-227 5.08e-22

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 98.36  E-value: 5.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17421   1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVgTFVFAPLTKILLKS-GWRYTL 207
Cdd:cd17421  81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEyDWQGAL 159

                       170       180
                ....*....|....*....|
gi 24653578 208 AIQGIIVLSCALFGLAFRPI 227
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI 179
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 49-229 5.15e-22

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 98.50  E-value: 5.15e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17355   1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAV-VIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRYT 206
Cdd:cd17355  81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIeAFGWRTA 160

                       170       180
                ....*....|....*....|...
gi 24653578 207 LAIQGIIVLSCALFGLAFRPIQP 229
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRP 183
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 49-227 1.28e-21

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 97.15  E-value: 1.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17425   1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTL 207
Cdd:cd17425  81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEmGWRGSF 160

                       170       180
                ....*....|....*....|
gi 24653578 208 AIQGIIVLSCALFGLAFRPI 227
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRPF 180
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 473-654 2.05e-21

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 96.72  E-value: 2.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 473 LDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKP--LWL 550
Cdd:cd17430 180 LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPrvVYL 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 551 NNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGL 630
Cdd:cd17430 260 FSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRL 339

                       170       180
                ....*....|....*....|....
gi 24653578 631 YVMTGSYNAAFYFAGGLILLSAFL 654
Cdd:cd17430 340 VDATKNYELIFYLAGSEVVLSALF 363
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 81-230 2.19e-21

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 96.42  E-value: 2.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  81 FGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIP 160
Cdd:cd17427  33 FHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQP 112

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653578 161 AVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAIQGIIVLSCALFGLAFRPIQPI 230
Cdd:cd17427 113 ALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQfGWRGSFLILGGLLLNCCVAGSLMRPLGPL 183
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
49-224 2.31e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 96.87  E-value: 2.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:COG2223   3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEyLFLIYGVLGGIGFCMVYIPAVVIIGFYFEK-WRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYT 206
Cdd:COG2223  83 GLLLLALAVSYW-LLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNA 161

                       170
                ....*....|....*...
gi 24653578 207 LAIQGIIVLSCALFGLAF 224
Cdd:COG2223 162 FLILGILLLVVAVLAWLF 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
46-222 9.89e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 94.55  E-value: 9.89e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  46 SGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIF 125
Cdd:COG2271   5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 126 AAICFGLSYFATSVEYLFLIYgVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GW 203
Cdd:COG2271  85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfGW 163

                       170
                ....*....|....*....
gi 24653578 204 RYTLAIQGIIVLSCALFGL 222
Cdd:COG2271 164 RAAFLILGLPGLLLALLRF 182
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 50-229 1.33e-20

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 94.17  E-value: 1.33e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17426   2 WAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLA 208
Cdd:cd17426  82 LIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIfGWRGSFL 161

                       170       180
                ....*....|....*....|.
gi 24653578 209 IQGIIVLSCALFGLAFRPIQP 229
Cdd:cd17426 162 ILGGLLLNCCVAGSLMRPIGP 182
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 49-224 1.79e-20

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 94.21  E-value: 1.79e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIdGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17353   2 RWLVLLGAVLMHLIL-GYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLK-SGWRYTL 207
Cdd:cd17353  81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINtVGVPTTF 160

                       170
                ....*....|....*..
gi 24653578 208 AIQGIIVLSCALFGLAF 224
Cdd:cd17353 161 LILGIIFLIIIVIGAFL 177
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 50-200 4.73e-20

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 92.19  E-value: 4.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17428   2 WVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLK 200
Cdd:cd17428  82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIE 152
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 473-652 9.95e-20

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 91.42  E-value: 9.95e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 473 LDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNN 552
Cdd:cd17421 179 IDFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIKKYHYHK 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 553 FALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYV 632
Cdd:cd17421 259 AYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYD 338

                       170       180
                ....*....|....*....|
gi 24653578 633 MTGSYNAAFYFAGGLILLSA 652
Cdd:cd17421 339 YTQTYDCSFYLAGGCYLLSS 358
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 50-229 4.56e-18

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 86.77  E-value: 4.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVS-----KAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAI 124
Cdd:cd17464   2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKddaqmRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 125 FAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GW 203
Cdd:cd17464  82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSvGL 161

                       170       180
                ....*....|....*....|....*.
gi 24653578 204 RYTLAIQGIIVLSCALFGLAFRPIQP 229
Cdd:cd17464 162 FNTLRVLCIFMFVLFLAGFTYKPLVP 187
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 462-654 2.20e-17

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 84.75  E-value: 2.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 462 PEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSS 541
Cdd:cd17423 186 PPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLAD 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 542 FPAVKPLWLNNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAAT 621
Cdd:cd17423 266 LGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGL 345

                       170       180       190
                ....*....|....*....|....*....|...
gi 24653578 622 FGSPIAGGLYVMTGSYNAAFYFAGGLILLSAFL 654
Cdd:cd17423 346 LGPPLSGWLRDITGDYTASFLVAGSFLLLGSLI 378
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 50-230 6.34e-17

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 83.23  E-value: 6.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17314   2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLA 208
Cdd:cd17314  82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFyGLALVYT 161

                       170       180
                ....*....|....*....|..
gi 24653578 209 IQGIIVLSCALFGLAFRPIQPI 230
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEPP 183
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 477-652 8.98e-17

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 82.49  E-value: 8.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALT 556
Cdd:cd17422 179 VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVI 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 557 AGGIATICSGIVINTATQWTFALFFGICIACFSALR--SLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMT 634
Cdd:cd17422 259 LLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHipLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWT 338

                       170
                ....*....|....*...
gi 24653578 635 GSYNAAFYFAGGLILLSA 652
Cdd:cd17422 339 QNYGSAFYSCAAGMALGA 356
MFS_1 pfam07690
Major Facilitator Superfamily;
52-226 2.29e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.93  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    52 VMVASFLCCTVIDGIvfcSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFG 131
Cdd:pfam07690   1 LFLAAFLAALGRSLL---GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   132 LSYFATSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKW-RALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAI 209
Cdd:pfam07690  78 LLLFASSL-WLLLVLRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLI 156

                         170
                  ....*....|....*..
gi 24653578   210 QGIIVLSCALFGLAFRP 226
Cdd:pfam07690 157 LAILSLLAAVLLLLPRP 173
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 477-654 3.82e-16

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 80.63  E-value: 3.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAY-GVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFAL 555
Cdd:cd17428 179 LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALiPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATICSGIVINTATQWTFALFFGICIACFSaLRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTG 635
Cdd:cd17428 259 IGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS-IFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQ 337

                       170
                ....*....|....*....
gi 24653578 636 SYNAAFYFAGGLILLSAFL 654
Cdd:cd17428 338 TYDIAFYFSGFCVLLGGFL 356
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 469-656 1.60e-15

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 79.11  E-value: 1.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 469 LSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLS-SFPAVKP 547
Cdd:cd17420 209 LRKIFNVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIAdMPPGVKK 288

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 548 LWLNNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIA 627
Cdd:cd17420 289 MYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIA 368

                       170       180       190
                ....*....|....*....|....*....|
gi 24653578 628 GGLYVMTGSYNAAFYFAGGLILL-SAFLCY 656
Cdd:cd17420 369 GLLRDSTGSYTVAFYLAGVPPLIgSSLLFF 398
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 450-656 2.50e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 78.24  E-value: 2.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 450 MLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAK-AAGMDEQAAYGVLSGIGVV 528
Cdd:cd06174 172 VVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLdLGGLSVAVAGLLLSLFGLA 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 529 NTFARIVCGSLSSFPAVKPLWLNnFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNA 608
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTA 330

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24653578 609 YGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAGGLILLSAFLCY 656
Cdd:cd06174 331 FGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-226 2.83e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.71  E-value: 2.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  43 PPDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITG 122
Cdd:COG2814   2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 123 AIFAAICFGLSYFATSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKS 201
Cdd:COG2814  82 LLLFALGSLLCALAPSL-WLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                       170       180
                ....*....|....*....|....*.
gi 24653578 202 -GWRYTLAIQGIIVLSCALFGLAFRP 226
Cdd:COG2814 161 fGWRWVFLVNAVLALLALLLLLRLLP 186
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
49-229 3.57e-15

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 77.99  E-value: 3.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:COG2807  16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFLIYgVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTL 207
Cdd:COG2807  96 GLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAAlGWRGAL 174

                       170       180
                ....*....|....*....|..
gi 24653578 208 AIQGIIVLSCALFGLAFRPIQP 229
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRP 196
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
462-668 7.77e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 73.76  E-value: 7.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 462 PEAVRRTLSTMLDttLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAK-AAGMDEQAAYGVLSGIGVVNTFARIVCGSLS 540
Cdd:COG2223 188 AAAAKASLRDQLE--ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLS 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 541 S-FPAVKPLWLNnFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAvELIGLEKLTNAYGFLMLFQGLA 619
Cdd:COG2223 266 DrIGGRRVLLIV-FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLG 343

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 24653578 620 ATFGSPIAGGLYVMTGSYNAAFYFAGGLILLSAFlcypLTWVSRWEERR 668
Cdd:COG2223 344 GFLGPLLFGALLDATGSYTAAFLVFAVLALVALV----LTLLLYRRPRR 388
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
 50-234 1.45e-13

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 72.91  E-value: 1.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKA-----YVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAI 124
Cdd:cd17465   2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 125 FAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GW 203
Cdd:cd17465  82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAiGL 161

                       170       180       190
                ....*....|....*....|....*....|.
gi 24653578 204 RYTLAIQGIIVLSCALFGLAFRPIQPITLSV 234
Cdd:cd17465 162 AHTFQVLSLFMFIQIFLSLTYKVFRRKTYRI 192
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 468-645 1.64e-13

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 72.90  E-value: 1.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 468 TLSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSF-PAVK 546
Cdd:cd17464 203 PLKKIFNFNIWKSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYiPGVK 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 547 PLWLNNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPI 626
Cdd:cd17464 283 KVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPI 362

                       170
                ....*....|....*....
gi 24653578 627 AGGLYVMTGSYNAAFYFAG 645
Cdd:cd17464 363 AGFLRDRLGSYDVAFYLAG 381
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
477-654 6.72e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 71.06  E-value: 6.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSS-FPAVKPLWLNNFAL 555
Cdd:COG2807 211 LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGLL 290

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATIcsgIVINTATQWTFALFFGICI-ACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMT 634
Cdd:COG2807 291 GLAGLLGL---LLAPGSLPWLWAVLLGLGQgGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT 367

                       170       180
                ....*....|....*....|
gi 24653578 635 GSYNAAFYFAGGLILLSAFL 654
Cdd:COG2807 368 GSWTAALLLLAALAVLMLVA 387
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
482-658 7.61e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.28  E-value: 7.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 482 AFMCLAFSGFLTMMGFFVPFTFLVDRAKAA-GMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALTAGGI 560
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 561 ATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGsYNAA 640
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAA 339

                       170
                ....*....|....*...
gi 24653578 641 FYFAGGLILLSAFLCYPL 658
Cdd:COG2271 340 FLLLAALALLAALLALLL 357
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 494-654 8.61e-13

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 70.19  E-value: 8.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 494 MMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAV--KPLWLNNFALTAGGIATICSGIVINT 571
Cdd:cd17425 197 VLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFkgRRIYLFSLALLLNGLSNLICAISASF 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 572 ATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYfAGGLILLS 651
Cdd:cd17425 277 PVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFY-ASSIFVVS 355


                ...
gi 24653578 652 AFL 654
Cdd:cd17425 356 AAL 358
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 57-247 9.79e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.15  E-value: 9.79e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  57 FLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFA 136
Cdd:cd06174   2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 137 TSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKIL---LKSGWRYTLAIQGI 212
Cdd:cd06174  82 PSF-WLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILassLGFGWRAVFLIAAA 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 24653578 213 IVLSCALFGLAFRPIQPITLSVTNEEGDEQEKKKL 247
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
 487-645 2.68e-12

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 68.67  E-value: 2.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 487 AFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLS-SFPAVKPLWLNNFALTAGGIATICS 565
Cdd:cd17465 194 AFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGdLIPGLKKIYLQVASFLLLGIMSMMI 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 566 GIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAG 645
Cdd:cd17465 274 PLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAG 353
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 477-652 1.73e-11

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 66.37  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKP--LWLNNFA 554
Cdd:cd17427 183 LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPriQYFFSFA 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 555 LTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMT 634
Cdd:cd17427 263 VMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVT 342

                       170
                ....*....|....*...
gi 24653578 635 GSYNAAFYFAGGLILLSA 652
Cdd:cd17427 343 GNYKYMYFVCGAIVIVAS 360
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 477-654 4.89e-11

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 64.98  E-value: 4.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFL---TMMGFFVP-FTFLVDRakaaGMDEQAAYGVLSGIGVVNTFARIVCGSLSSfpAVKPLWLNN 552
Cdd:cd17355 206 ALRSASFWLLALAFFLcgfAVVGLIVHlVPYLADR----GISPAAAAVALALIGLFNIVGRLLSGWLGD--RYSPRRLLA 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 553 FALTAGGIATICSGIVINTATQ-WTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLY 631
Cdd:cd17355 280 ASYALRALGLALLLLLPFPPLAlLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359

                       170       180
                ....*....|....*....|...
gi 24653578 632 VMTGSYNAAFYFAGGLILLSAFL 654
Cdd:cd17355 360 DRTGSYTAAWALAVALGLIAALL 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
472-656 7.25e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.22  E-value: 7.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 472 MLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLn 551
Cdd:COG2814   1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 552 nFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLy 631
Cdd:COG2814  80 -LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL- 157

                       170       180
                ....*....|....*....|....*
gi 24653578 632 VMTGSYNAAFYFAGGLILLSAFLCY 656
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLL 182
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
50-226 9.93e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.74  E-value: 9.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIqeqLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFG--FRPVTITGAIFAA 127
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTY---LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 128 ICFGLSYFATSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRY 205
Cdd:COG2271 260 LALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLdATGYQA 338

                       170       180
                ....*....|....*....|.
gi 24653578 206 TLAIQGIIVLSCALFGLAFRP 226
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 477-650 2.18e-10

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 62.93  E-value: 2.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQA-AYGVLSGIGVVNTFARIVCGSLSSFPAVKpLWlnNFAL 555
Cdd:cd17429 179 LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNdKFPLTSIIAIVHIFGKVILGIICDLPCIS-VW--NVFI 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATICSGIVINTATQWTFALFFGIcIACFSALRSLIAV---ELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYV 632
Cdd:cd17429 256 LANFTLGVCILILPLMHTYTGLAIVCAL-IGFSSGYFSLMPVvteDLVGIKNLANAYGIIICANGISALLGPPFAGWIYD 334

                       170
                ....*....|....*...
gi 24653578 633 MTGSYNAAFYFAGGLILL 650
Cdd:cd17429 335 ITQKYDFSFYVCGLLYMV 352
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 50-215 1.35e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 60.28  E-value: 1.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTV--IDGIVFcsGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAA 127
Cdd:cd17319   2 WRIIPLLFLAYVInyLDRVNI--SVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 128 ICFGLSYFATSVEYLFLIYGVLgGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRY 205
Cdd:cd17319  80 LFTALTGFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRW 158

                       170
                ....*....|
gi 24653578 206 TLAIQGIIVL 215
Cdd:cd17319 159 AFIIEGLLGL 168
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 478-654 1.95e-09

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 59.93  E-value: 1.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 478 LKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKA-AGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFpaVKPLWLNNFALT 556
Cdd:cd17353 210 LRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEfAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK--IGRKNTLSIAFL 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 557 AGGIAtiCSGIVINTATQWTFALFFGICIACFSALRSLIAV---ELIGLEKLTNAYGFLMLFQGLAATFGsPIAGGLYVM 633
Cdd:cd17353 288 IQGVA--MFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPAltaDFFGTKNAGTNYGLLYTAKGVGGLIG-PIIAAYVLY 364

                       170       180
                ....*....|....*....|.
gi 24653578 634 TGSYNAAFYFAGGLILLSAFL 654
Cdd:cd17353 365 TGGYNAAFIIAAALSLVALAL 385
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
63-247 5.29e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 58.71  E-value: 5.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  63 IDGIVFCS-GLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVeY 141
Cdd:COG0738  19 LWGFATALwGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY-P 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 142 LFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSG----WRYTLAIQGIIVLSC 217
Cdd:COG0738  98 LLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslsWHLPYLILAVLLLLL 177

                       170       180       190
                ....*....|....*....|....*....|
gi 24653578 218 ALFgLAFRPIQPITLSVTNEEGDEQEKKKL 247
Cdd:COG0738 178 ALL-FLRSKLPEIEEEEEEAAGSAASLKSL 206
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 477-654 6.68e-09

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 58.28  E-value: 6.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALT 556
Cdd:cd17424 179 FLLMPDFLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFA 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 557 AG--GIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMT 634
Cdd:cd17424 259 VGmdGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTT 338

                       170       180
                ....*....|....*....|
gi 24653578 635 GSYNAAFYFAGGLILLSAFL 654
Cdd:cd17424 339 GTYTAAFLLSGFSMIFSSLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
486-656 1.29e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.04  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   486 LAFSGFLTMMGFFVPFTFLV-DRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLnnFALTAGGIATIC 564
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   565 SGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGsYNAAFYFA 644
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170
                  ....*....|..
gi 24653578   645 GGLILLSAFLCY 656
Cdd:pfam07690 158 AILSLLAAVLLL 169
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 477-654 3.00e-08

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 56.27  E-value: 3.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQA-AYGVLSGIGVVNTFARIVCGSLSSFpAVKPLWLNNFAL 555
Cdd:cd17314 202 IFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVADF-FGGRLSTLSILL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATICSGIVInTATQWTFALF---FGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYV 632
Cdd:cd17314 281 TILGLGLCAFLFLL-KMTPVGLVLTgslLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYD 359

                       170       180
                ....*....|....*....|..
gi 24653578 633 MTGSYNAAFYFAGGLILLSAFL 654
Cdd:cd17314 360 RTPSYISAVYIYAVIVFLASAI 381
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 476-654 4.02e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 4.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 476 TLLKSPAFMCLAFSGFLTMMGFFVPFTFL-VDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLS-SFPAVKPLwlnNF 553
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPFLpLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSdRIGRKPLI---LI 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 554 ALTAGGIATICSGIVINTATQWTFALFFGICIA-CFSALRSLIAvELIGLEKLTNAYGFLMLFQGLAATFGsPIAGGLYV 632
Cdd:cd17325 271 GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLG-PLLGGFLY 348

                       170       180
                ....*....|....*....|..
gi 24653578 633 MTGSYNAAFYFAGGLILLSAFL 654
Cdd:cd17325 349 DAFGFATPFLAAAALLLLAAVL 370
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 77-234 4.02e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 55.20  E-value: 4.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEyLFLIYGVLGGIGFCM 156
Cdd:COG0477  40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPE-LLIAARALQGIGAGG 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 157 VYIPAVVIIGFYF-EKWRALATGVAMCGSGVGtFVFAPLTKILLKS--GWRYTLAIQGIIvlscALFGLAFRPIQPITLS 233
Cdd:COG0477 119 LMPGALALIAELFpARERGRALGLWGAAIGLG-LALGPLLGGLLVAalGWRWIFLINAPL----GLLALVLRLRLPESRG 193


                .
gi 24653578 234 V 234
Cdd:COG0477 194 L 194
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 473-656 5.37e-08

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 55.65  E-value: 5.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 473 LDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNN 552
Cdd:cd17426 186 LDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYF 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 553 FALT--AGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGL 630
Cdd:cd17426 266 FAASvlYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRL 345

                       170       180
                ....*....|....*....|....*.
gi 24653578 631 YVMTGSYNAAFYFAGGLILLSAFLCY 656
Cdd:cd17426 346 NDIYGDYKYTYWACGIVLIISSIYLF 371
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 50-226 5.55e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 55.44  E-value: 5.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    50 WVVMVASFLCcTVIDGI-VFCSGLIQEQLMAEFGVSKAYVAFV-SSLLSGcyLMAGPFVSAM-ANRFGFRPVTITGAIFA 126
Cdd:TIGR00895  16 WRAIILSFLI-MLMDGYdLAAMGFAAPAISAEWGLDPVQLGFLfSAGLIG--MAFGALFFGPlADRIGRRRVLLWSILLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   127 AICFGLSYFATSVEYLfLIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWR 204
Cdd:TIGR00895  93 SVFTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVfGWR 171

                         170       180
                  ....*....|....*....|..
gi 24653578   205 YTLAIQGIIVLSCALFGLAFRP 226
Cdd:TIGR00895 172 SLFYVGGIAPLLLLLLLMRFLP 193
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 486-656 1.32e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 1.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 486 LAFSGFLTMMGFFVPFTFLVDRAKAAGMDEqAAYGVLSGI-GVVNTFARIVCGSLSSFPAVKPLWLnnFALTAGGIATIC 564
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASV-AQIGLIVAAyALAQLLFSPPAGRLSDRFGRKRLLL--LGLLLLAVSTLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 565 SGIViNTATQWTFALFF-GICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGsPIAGGLYVMTGSYNAAFYF 643
Cdd:cd17325  78 FAFA-TSYWQLLLARFLqGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIG-PLLGGLLADALGYRAPFLV 155

                       170
                ....*....|...
gi 24653578 644 AGGLILLSAFLCY 656
Cdd:cd17325 156 CAALALLALVLAL 168
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 76-226 1.44e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 1.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  76 QLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYgVLGGIGFC 155
Cdd:cd17325  21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASA 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653578 156 MvYIPAV--VIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLK-SGWRYTLAIQGIIVLSCALFGLAFRP 226
Cdd:cd17325 100 A-VWPAAmaLIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLLP 172
MFS_1 pfam07690
Major Facilitator Superfamily;
462-624 1.76e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   462 PEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSS 541
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   542 -FPAVKPLWLNNFALTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAA 620
Cdd:pfam07690 261 rLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340


                  ....
gi 24653578   621 TFGS 624
Cdd:pfam07690 341 ALGP 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
50-225 1.79e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.73  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIqeqLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPY---LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIygVLGGIGFCMVYIPAVV--IIGFYFE-KWRALATGVAMCGSGVGTFVFAPLTKILLKS--GWR 204
Cdd:COG2223 285 LLLLALALGSLWLFLV--LFLLLGLALGGGNGAVfaLVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYT 362

                       170       180
                ....*....|....*....|.
gi 24653578 205 YTLAIQGIIVLSCALFGLAFR 225
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLY 383
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 87-220 3.19e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.97  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  87 YVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEyLFLIYGVLGGIGFCMVYIPAVVIIG 166
Cdd:cd17317  26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE-LFLVLRFLVGVTSAGIFTVGFVLGM 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24653578 167 -FYFEKWRALATGVAMCGSGVGTFVFAPLTkILLKSgWRY---TLAIQGIIVLSCALF 220
Cdd:cd17317 105 eIVGPKYRSFVGILFGLFWALGYMLLALLA-YLIRD-WRWlqlAISLPGLLFLLLLWW 160
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 57-220 5.54e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.20  E-value: 5.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  57 FLCC--TVIDGI-VFCSGLIQEQLMAEFGVSKAYVAFVSSL-LSGcyLMAGPFVSA-MANRFGFRPVTITGAIFAAICFG 131
Cdd:cd17365   2 ALCFliIVLDGFdLAVMGFVAPALAQDWGLSPAQLGPVGSAaLFG--MAIGALLAGpLADRFGRKRVLLVSVALFGLFTL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 132 LSYFATSVEYLFLIYGVLG-GIGFCMVYIpAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAI 209
Cdd:cd17365  80 LTAFAQSVLQLALLRFLTGlGLGAAMPNA-ITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAfGWRSVFLL 158

                       170
                ....*....|.
gi 24653578 210 QGIIVLSCALF 220
Cdd:cd17365 159 GGVPPLILLPL 169
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 76-220 6.08e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 52.28  E-value: 6.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  76 QLMAEFGVSKAYVAFVSSLLSGCYlMAGPFVSAM-ANRFGFRPVTITGAIFAAIC---FGLSYFAtsveYLFLIYGVLGG 151
Cdd:cd17312  28 PIVEEIGLSKDDLGIIGSAFLIAY-AVGKFISGFlSDRSNIRRFMSAGLLLSALAnifMGFSTSL----WFFAVLWGLNG 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653578 152 IGFCMVYIPAVVIIGFYFE-KWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAIQGIIVLSCALF 220
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSkKERGTVYGIWSTSHNFGGILAPILAASLASYyGWRAAFLVPGIVGLVVAII 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 477-655 1.17e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 51.40  E-value: 1.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKA-AGMDEQAAYGVLSGIGVVNTFARIVCGSLSSfpavkplWLNNFAL 555
Cdd:cd17324 194 LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDvPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD-------RGGRRAL 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATICSGIVINTATQWTFALFFGICIACF------SALRSLIAveLIGLEKLTNAYGFLMLFQGLAATFGSPIAGG 629
Cdd:cd17324 267 LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLgffaahSALQTRVL--RLAPEARGLASSLYLAAYNLGGALGAALGGL 344

                       170       180
                ....*....|....*....|....*.
gi 24653578 630 LYVMTGsYNAAFYFAGGLILLSAFLC 655
Cdd:cd17324 345 VLDHGG-WAGVGWVGAALLLLALLLA 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
462-621 1.49e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 1.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 462 PEAVRRTLSTMLDttLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKA-AGMDEQAAYGVLSGIGVVNTFARIVCGSLS 540
Cdd:COG2814 190 PAARARLRGSLRE--LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLA 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 541 SFPAVKPLWLNNFALTAGGIATIcsGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAA 620
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLL--ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                .
gi 24653578 621 T 621
Cdd:COG2814 346 P 346
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
50-187 1.83e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.36  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIqeqLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLY---LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653578 130 FGLSYFATSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVG 187
Cdd:COG2814 287 LLLLALAGSL-WLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLG 344
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 81-250 2.42e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 2.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  81 FGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLG-GIGFCMVYi 159
Cdd:cd17473  30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGiGVAGIMTL- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 160 pAVVIIGFYFE-----KWRALATGVamcgSGVGTFVFAPLTKILLKSGWRYTLAIQGiIVLSCALFGLAFRPIQPITLSV 234
Cdd:cd17473 109 -ATALIGDYFEgeeraKMLGLQSAA----MSLGGVVFLLLGGALAEIGWRAPFLVYL-LALPVLILVLLFLPEPARKSKS 182

                       170
                ....*....|....*.
gi 24653578 235 TNEEGDEQEKKKLNGH 250
Cdd:cd17473 183 AASPGAATAAALPWKR 198
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 480-654 2.82e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 49.85  E-value: 2.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 480 SPAFMCLAFSGFLTMMGFFvPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSsfPAVKPLWLNNFALTAGG 559
Cdd:cd17370 199 PKAFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLS--DRIGRKKLLILGYLSLA 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 560 IATICSGIVINTATQWTFALFFGICIACF-SALRSLIAvELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTgSYN 638
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVA-DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SPS 353

                       170
                ....*....|....*.
gi 24653578 639 AAFYFAGGLILLSAFL 654
Cdd:cd17370 354 AAFLFSAVLALIALLL 369
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-225 4.48e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.50  E-value: 4.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYgVLGGIGFCM 156
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL-ALLGLGLGL 304

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653578 157 VYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAIQGIIVLSCALFGLAFR 225
Cdd:cd17325 305 VFPATLALLADIVpPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAVLFLLLR 375
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 53-233 8.29e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 48.39  E-value: 8.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  53 MVASFLCCTVI-DGIVFCSGLIQEqlmaEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFG 131
Cdd:cd17475   1 ATLAQAAASLVaQGIPALAPFLQE----DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 132 LSYFATSVEYLFLIYgVLGGIGFCMVYiPAV--VIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKIL-LKSGWRYTLA 208
Cdd:cd17475  77 LMALVGSYPVLLVLL-FLVGAGYGSVQ-PGGgrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFV 154

                       170       180
                ....*....|....*....|....*.
gi 24653578 209 IQGIIVLSCA-LFGLAFRPIQPITLS 233
Cdd:cd17475 155 VAGLVSILAAvLFWLFYREPPAASAA 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 486-656 8.29e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 8.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 486 LAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLS-SFPAVKPLWLNNFALTAGGIAtic 564
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAdRFGRRPVLLLGLLLFALGALL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 565 SGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVM-TGSYNAAFYF 643
Cdd:cd06174  78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLI 157

                       170
                ....*....|...
gi 24653578 644 AGGLILLSAFLCY 656
Cdd:cd06174 158 AAALALLAAILLL 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 48-216 9.05e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 9.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  48 WAWVVMVASFLCCTVIDGIvfcSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAA 127
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSF---STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 128 ICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKSGWRYT 206
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360

                       170
                ....*....|
gi 24653578 207 LAIQGIIVLS 216
Cdd:cd06174 361 GAFLVLAVLL 370
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 77-230 9.99e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 48.32  E-value: 9.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVeYLFLIYGVLGGIGFCM 156
Cdd:cd17478  22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-WLLLLLVALAGIGSAA 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653578 157 VYIPAVVIIGFYFEKWRALATGVAMCGSGVGtFVFAPLTKILLKSGW---RYTLAIQGIIVLSCALFGLAFRPIQPI 230
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLG-FALGPLIAAALVALFgglGLLILLIIPGLAVALLLLRLRPLKKPE 176
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 52-247 1.49e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.59  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  52 VMVASFLCCTVID-GIVFCSGLIQEqlmaeFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICF 130
Cdd:cd17489   1 ILLANFFFFLSFYlLLPVLPLYAHD-----LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 131 GLSYFATSVEYLFLIYGVLG-GIGFCMVYIPAVVI-----------IGfyfekWRALATGVAMcgsgvgtfVFAPLTKIL 198
Cdd:cd17489  76 LLYLLATSVALLLVLRLIHGiGWGAFTTAAATLVAdiippsrrgegIG-----YYGLATTLAM--------ALGPALGLF 142

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 24653578 199 LKSGWRYTLAIQGIIVLSCALFGLAFRPIQPITLSVTNEEGDEQEKKKL 247
Cdd:cd17489 143 LYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRL 191
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
81-224 2.18e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 2.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  81 FGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVE-YLFLIYGVLGGIGFCMVYI 159
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNlWLLLVLAALAGIGLGAILV 338

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 160 PAVVII----------------GFYFekwrALATGVAMCGSGVGTFVFAPltkILLKSGWRYTL-----AIQGI----IV 214
Cdd:COG2211 339 LPWAMLadvvdydewktgrrreGLYF----GIFTFAIKLGQALAGALAGL---LLALFGYVAGAaqspsALTGIrllfFL 411

                       170
                ....*....|
gi 24653578 215 LSCALFGLAF 224
Cdd:COG2211 412 LPAVLLLLAA 421
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 64-219 2.36e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.30  E-value: 2.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  64 DGIVFcsGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLf 143
Cdd:cd17371  14 DLLLL--GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQL- 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 144 LIYGVLGGIGFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILL-----KSGWRYTLAIQGIIVLSC 217
Cdd:cd17371  91 LILRALAGLGFGGEWAAGAALMAEYVpARHRGKALGYVQSGWAVGWLLATLLAALLFpllppEIAWRVLFLLGALPALLV 170


                ..
gi 24653578 218 AL 219
Cdd:cd17371 171 LF 172
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 77-231 2.54e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.78  E-value: 2.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYgVLGGIGFCM 156
Cdd:cd17477  22 RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR-FVMGIGLAG 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653578 157 VYIPAVVII-GFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSGWRYTLAIQGIIVLSCALFGLAFRPIQPIT 231
Cdd:cd17477 101 LFVVSESWLnALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIE 176
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 71-220 3.41e-05

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 3.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  71 GLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRpVTITGAIFAAICFGLSYFATSVEYLFLIYGVLG 150
Cdd:cd17339  19 GPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLE-RTLLLALLLLAAGILLRSLGGIALLFLGTALAG 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653578 151 -GIGFCMVYIPAVviIGFYFEKWRALATG---VAMC-GSGVGTFVFAPLTKILLkSGWRYTLAIQGIIVLSCALF 220
Cdd:cd17339  98 aGIAVGNVLLPSL--IKRDFPRRVGLMTGlytTSMNlGAALASGLSVPLAQALG-GGWRGALAIWALPALLALLI 169
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 77-224 3.59e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 46.85  E-value: 3.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYvAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYL---FLIYGVLGGIG 153
Cdd:cd06179  24 IVADLGPSSNS-TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLiggQALIGIGAGTQ 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653578 154 FCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLkSGWRYTLAIQgIIVLSCALFGLAF 224
Cdd:cd06179 103 GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANA-AGWRWIFYIN-AIFNALALILLFF 171
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 50-219 3.59e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.39  E-value: 3.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLccTVIDGIVFcSGLIQeQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17324   2 LALALAAFA--IGTTEYVI-QGLLP-DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVEYLFLIYGVLGgiGFCMVYIP-AVVIIGFYFEK-WRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYT 206
Cdd:cd17324  78 NLLAALAPSFALLLLARALAG--LAHGGFWAiAAAYAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAA 155

                       170
                ....*....|...
gi 24653578 207 LAIQGIIVLSCAL 219
Cdd:cd17324 156 FLAIAVLALLAAL 168
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 100-166 4.10e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.42  E-value: 4.10e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24653578 100 LMAGPFVSAMANRFGFRPVTITGAIFAAICF-GLSYFATSVEYLFLIYGVLG-GIGFCMVYIPAVVIIG 166
Cdd:cd17504 231 LIAGPLAGRLIARVGPRRVLLIGLVISAVGLlLLALLHSSLWALVVALLLIGiGLGLAFASLPNIVVES 299
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
46-224 4.96e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.02  E-value: 4.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  46 SGWAWVVMVASFLCCTVIDGIVfcsGLIqEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFR--PVTITGA 123
Cdd:COG2807 214 SPLAWLLTLFFGLQSLLYYAVV---AWL-PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrpLLLLLGL 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 124 IFAAICFGLSYFATSveyLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWR--ALATGVAMCGSGVGTFVFAPLTKIL--L 199
Cdd:COG2807 290 LGLAGLLGLLLAPGS---LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeaAALSGMAQSVGYLLAALGPLLVGALhdA 366

                       170       180
                ....*....|....*....|....*
gi 24653578 200 KSGWRYTLAIQGIIVLSCALFGLAF 224
Cdd:COG2807 367 TGSWTAALLLLAALAVLMLVAGLLA 391
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 477-658 5.16e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.02  E-value: 5.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKA-AGMDEQAAYGVLSGIGVVNTFARIVCGSLSSfPAVKPLWLNNFAL 555
Cdd:cd17474 194 ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGRLLK-KRFGARRILVIGL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLE---KLTNAYGFlMLFqgLAATFGSPIAGGLYv 632
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEergTASSLYNF-VRF--LGQAVGPLLFGLLL- 348

                       170       180
                ....*....|....*....|....*.
gi 24653578 633 MTGSYNAAFYFAGGLILLSAFLCYPL 658
Cdd:cd17474 349 EIFGLSAPFLVGAAIALAAAVLLALL 374
2_A_01_02 TIGR00880
Multidrug resistance protein;
100-219 5.32e-05

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 43.79  E-value: 5.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   100 LMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFlIYGVLGGIG--FCMVYIPAvVIIGFYFEKWRALAT 177
Cdd:TIGR00880  12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLI-IARFLQGFGaaFALVAGAA-LIADIYPPEERGVAL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 24653578   178 GVAMCGSGVGTFVFAPLTKILL-KSGWRYTLAIQGIIVLSCAL 219
Cdd:TIGR00880  90 GLMSAGIALGPLLGPPLGGVLAqFLGWRAPFLFLAILALAAFI 132
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 77-225 5.98e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.01  E-value: 5.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYVAFVSS---LLSGCYLMAGpfvSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEylFLIYG-VLGGI 152
Cdd:cd17321  22 IARDLGASPSQLQWVVNaylLAFAALLLLA---GRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA--FLIAArALQGI 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653578 153 GFCMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWRYTLAIQGIIVLSCALFGLAFR 225
Cdd:cd17321  97 GAAAIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELfGWRWIFLINVPIGLVALLLARTFS 171
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 486-659 1.18e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.89  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 486 LAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAyGVLSGIGVVNT-FARIVCGSLSSFPAVKPLWLnnFALTAGGIATIC 564
Cdd:cd17489   1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA-GLVVGLFTLAAlLARPFAGRLLDRFGRKRLLL--IGLLIFALATLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 565 SGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYvMTGSYNAAFYFA 644
Cdd:cd17489  78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY-QHLGFAVLFIVA 156

                       170
                ....*....|....*
gi 24653578 645 GGLILLSAFLCYPLT 659
Cdd:cd17489 157 AVLALLALLLVFLVK 171
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 50-223 2.24e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.13  E-value: 2.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIvfcSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd17316 180 LLLILLWFFISFGYYGL---TTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFA--TSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSGWRYTL 207
Cdd:cd17316 257 ALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336

                       170
                ....*....|....*.
gi 24653578 208 AIqgIIVLSCALFGLA 223
Cdd:cd17316 337 PA--LILALLAIVALI 350
Sugar_tr pfam00083
Sugar (and other) transporter;
52-224 6.54e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 42.64  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    52 VMVASFLCCTVIDGIVFCSGLIQEQLmaefGVSKAyvaFVSSLLSGCYLMAGPFVSAM-ANRFGFRPVTITGAIFAAICF 130
Cdd:pfam00083 259 VMLQIFQQLTGINAIFYYSTTIFENL----GLSDS---FLVTIIVGVVNFVFTFIAIFlVDRFGRRPLLLLGAAGMAICF 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   131 ----GLSYFATSVEY------LFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLK 200
Cdd:pfam00083 332 vilgIVALLGVSKSDwagivaIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITD 411

                         170       180
                  ....*....|....*....|....*
gi 24653578   201 S-GWRYTlaiqGIIVLSCALFGLAF 224
Cdd:pfam00083 412 AiGLGYT----FFIFAGLLVLFIIF 432
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 492-662 7.21e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.56  E-value: 7.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 492 LTMMGFFVPFT------FLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLnnFALTAGGIATICS 565
Cdd:cd17323   4 ISFLTFVVTFGssiyspALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYL--VSLFIFVIFQIGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 566 GIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGsPIAGGLYVMTGSYNAAFYFA- 644
Cdd:cd17323  82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALG-PIIGGFITQSLGWRWIFWFLa 160

                       170       180
                ....*....|....*....|
gi 24653578 645 --GGLILLSAFLCYPLTWVS 662
Cdd:cd17323 161 iiSGFCLILIFLFLPIVLLL 180
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 88-237 1.22e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 41.69  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  88 VAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITG-------AIFAAICFGLSYFATSV-------------------EY 141
Cdd:cd17377  41 VSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGlaldilfAYFNALAPSYEFFAVSRflvgvmnggmslvafvllnEC 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 142 LFLIY----GVLGGIGFCmVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTF-VFAPLTKILLKSGW------RYTLAIQ 210
Cdd:cd17377 121 VGKSYwalaGSLGGLFFA-VGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLsLFIPGRTLILMYVWfvcslvYYGLTLN 199

                       170       180       190
                ....*....|....*....|....*....|..
gi 24653578 211 -----GIIVLSCALFGLAFRPIQPITLSVTNE 237
Cdd:cd17377 200 agdlgGNIYLNLALSGLVELPAYPLCIYLINQ 231
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
459-659 1.29e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 459 RICPEAVRRTLSTMLdTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGvvntfarIVCGS 538
Cdd:COG2211 207 RPVPEEEKVSLKESL-KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALY-------FLAAL 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 539 LSSFPAvkPLWLNNF----ALTAGGIATICSGIVI------NTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTN- 607
Cdd:COG2211 279 LGAPLW--PRLAKRFgkkkAFIIGLLLAALGLLLLfflgpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTg 356

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653578 608 ------AYGFLMLFQGLAATFGSPIAGGLY--------------VMTGSYNAAFYFAGGLILLSAFL--CYPLT 659
Cdd:COG2211 357 rrreglYFGIFTFAIKLGQALAGALAGLLLalfgyvagaaqspsALTGIRLLFFLLPAVLLLLAALLllFYPLT 430
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 77-215 1.58e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSkayVAFVSSLLSGCYL---MAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLgGIG 153
Cdd:cd17324 225 LTDVPGFS---SSAIIGLLLLFGVagvVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLW-GLG 300

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653578 154 FCMVYIPAVVIIGFYFEKWRALATGVAMC----GSGVGTFVFAPLtkiLLKSGWRYTLAIQGIIVL 215
Cdd:cd17324 301 FFAAHSALQTRVLRLAPEARGLASSLYLAaynlGGALGAALGGLV---LDHGGWAGVGWVGAALLL 363
MFS_1 pfam07690
Major Facilitator Superfamily;
77-192 1.89e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578    77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFG-FRPVTITGAIFAAICFGLSYFATSVEYLFLIYG-VLGGIGF 154
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAlLLLGFGF 305

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 24653578   155 CMVYIPAVVIIGFYF-EKWRALATGVAMCGSGVGTFVFA 192
Cdd:pfam07690 306 GLVFPALNALVSDLApKEERGTASGLYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
77-225 2.18e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  77 LMAEFGVSKAYVAFVSSLLSGCyLMAGPFV-SAMANRFGFRPVTITGAIFAAICFGLSYFATSVeYLFLIYGVLGGIGFC 155
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGG-MTIGRFLgGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGP-WLALIGLALVGLGLS 314

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653578 156 MVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILL-KSGWRYTLAIQGIIVLSCALFGLAFR 225
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLILLLALALK 385
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 49-224 2.41e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  49 AWVVMVASFLCCTVIdgIVFCSGLIQEQLmaEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAI 128
Cdd:cd17330   1 LFLVVFLDALGFGIV--FPVLPFYVREFN--KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 129 CFGLSYFATSVEYLFL---IYGVLGG-IGFCMVYIPAVVIigfyfEKWRALATGVAMCGSGVGtFVFAPLTKILLKSGWR 204
Cdd:cd17330  77 SYVLLGLSRNLWLLFLarfLDGLTGGnVSVAQAYIADITD-----EEERAKAFGIISAAFGLG-FILGPALGGFLSTPYG 150

                       170       180
                ....*....|....*....|..
gi 24653578 205 YTLAIQ--GIIVLSCALFGLAF 224
Cdd:cd17330 151 YALPFLvaAALALLNLVLVLFF 172
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 483-655 2.55e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 2.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 483 FMCLAFSGFLTMMGFFVPFTFLVDR-AKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALTAGGIA 561
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 562 TICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAF 641
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338

                       170
                ....*....|....
gi 24653578 642 YFAGGLILLSAFLC 655
Cdd:cd17316 339 LILALLAIVALIVA 352
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-224 2.78e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.66  E-value: 2.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  80 EFGVSKAYVAFVSSLLSGCYLMAGPFVSAMA----NRFG-FRPVTITGAIFAAICFGLSYFATSVE------YLFLIYgV 148
Cdd:COG2211  40 VLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTY-L 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 149 LGGIGFCMVYIPAVVIIGFYFE--KWRALATGVAMCGSGVGTFVFAPLTKILLK-------SGWRYTLAIQGIIVLSCAL 219
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTPdyEERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaaLGYRLTALIFAVLGLLAFL 198


                ....*
gi 24653578 220 FGLAF 224
Cdd:COG2211 199 LTFFG 203
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 89-220 2.90e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 40.71  E-value: 2.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  89 AFVSSLLSGCylMAGPFVSA-MANRFGFRP---VTITGAIFAAICFGLSYFATSVEYLF---LIYGVLGGI--GFCMVYI 159
Cdd:cd17357  53 LIVSIFFIGG--AIGSFISAfLANRFGRKNgllISNALLVVSSLLMFLSKSAKSPELLIfgrFLVGIACGLstGFVPMYL 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24653578 160 ----PAvviigfyfeKWRALA---TGVAMCGSGVGTFVFApLTKIL-LKSGWRYTLAIQGIIVLSCALF 220
Cdd:cd17357 131 qeisPS---------ELRGALgslTQIGVTLGILLGQVFG-LPSVLgTETLWPYLLFFPGIPALLQLAA 189
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 76-224 3.40e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 3.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  76 QLMAEFGVSKAYVafvsSLLSGCYLMAG----PFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEyLFLIYGVLGG 151
Cdd:cd17474  24 AIAEALGASPAQV----GLLITAFTLPAavlmPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA-LLLAGRALQG 98

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653578 152 IGFCMVYIPAVVIIG-FYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSGWRYtlaiqgIIVLSCALFGLAF 224
Cdd:cd17474  99 IGAAGLGPLALTLIGdLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRY------PFFLLAALIPVAF 166
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 77-144 3.55e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 40.28  E-value: 3.55e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24653578  77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFL 144
Cdd:cd17331  26 LTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFL 93
PRK03699 PRK03699
putative transporter; Provisional
 56-248 4.52e-03

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 39.91  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578   56 SFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLmAGPFVSAM-ANRFGFRPVTITGAIFAAIC----- 129
Cdd:PRK03699  12 SFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGIL-ISIFLNAWlMEIIPLKRQLIFGFALMILAvaglm 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  130 FGLSYFATSVeYLFLIyGVLGGIGFCmvyIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSG--WRYTL 207
Cdd:PRK03699  91 FSHSLALFSI-AMFVL-GVVSGITMS---IGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSieWYWVY 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 24653578  208 AIQGIIVLscALFGLAFRPIQPITLSVTNEEGDEQEKKKLN 248
Cdd:PRK03699 166 ACIGLVYV--AIFILTLFSEFPALGKHAPKADKPVAKEKWG 204
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 477-658 4.53e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 4.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 477 LLKSPAFMCLAFSGFLTMMGFFVPFTflvdrAKAAGMDEQAAYGVLSG-IGVVNTFARIVCGSLSsfPAVKPLWLNNFAL 555
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLL-----AKEVLGGGAAGYGLLLAaFGVGALLGALLLGRLS--KRRRRGRLLLIGA 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 556 TAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLyVMTG 635
Cdd:cd06173 282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL-ADAL 360

                       170       180
                ....*....|....*....|...
gi 24653578 636 SYNAAFYFAGGLILLSAFLCYPL 658
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLLL 383
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 50-224 4.82e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 4.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  50 WVVMVASFLCCTVIDGIVFCSGLIQEQLMaefGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIC 129
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLAKEVL---GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 130 FGLSYFATSVeYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKW---RALATG--VAMCGSGVGTFVFAPLTKILlksGWR 204
Cdd:cd06173 288 LLVLGLSPSL-WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElrgRVFSVYnaLNSGAMPLGALLAGLLADAL---GLS 363

                       170       180
                ....*....|....*....|
gi 24653578 205 YTLAIQGIIVLSCALFGLAF 224
Cdd:cd06173 364 AVFLLAGALLLLAALLLLLL 383
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 91-164 5.01e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.87  E-value: 5.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  91 VSSLLSGCYLMAG--------PFVSAMANRFGFRPVTITG-AIFAAICFGLSYF--ATSVEYLFLIYGVLgGIGFCMVYI 159
Cdd:cd17503 211 YSAFESGLVLAPGglasailsPLVGRLLDKFGPRLLLLAGlLLLALGTLLLAFLtpDTSLWLIILPLFIR-GLGMGLVFM 289


                ....*
gi 24653578 160 PAVVI 164
Cdd:cd17503 290 PLNTL 294
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 78-225 5.43e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.46  E-value: 5.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  78 MAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRP--VTITGAIFAAICFGLSYFATSVeYLFLIYGVLGGIGFC 155
Cdd:cd17352 210 AKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRlyLYIFTLLILGLSLLAFPLATTY-VGLIVFSVLFGFCSG 288

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24653578 156 MVYIPAVVIIGFYFEKWR-ALATGVAMCGSGVGTFVFAPLTKILL--KSGWRYTLAIQGIIVLSCALFGLAFR 225
Cdd:cd17352 289 SYSSLTPVILADLVGLEKlSNAYGLVLLFQGLAALVGPPIAGLLRdyTGDYDAAFYFCGACLLLSGVLLFLLP 361
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 68-242 5.98e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.59  E-value: 5.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  68 FCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYG 147
Cdd:cd06180  16 FAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRF 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 148 VLgGIGFCMVYIPAVVIIGFYFEKW-RALATGVAMCGSGVGTFVFAPLTKILLKSGWRYTLAIQGIIVLSCALFGLAFRP 226
Cdd:cd06180  96 LA-GAASAFVFVFGSNLVLHHATAAgRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLL 174

                       170
                ....*....|....*.
gi 24653578 227 IQPITLSVTNEEGDEQ 242
Cdd:cd06180 175 LRRGPSAPTEASAAES 190
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 172-246 6.31e-03

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 39.63  E-value: 6.31e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653578 172 WRALATGVAMCGSgVGTFVfapLTKILLKSGWRYTLAIQGIIVLSCALFGLAFRPIQPITLSVTNEEGDEQEKKK 246
Cdd:cd17343 129 WSVLSTSMNLAGS-LGPIL---ATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKK 199
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 482-654 8.24e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.09  E-value: 8.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 482 AFMCLAFSGFLTMMGFFVPfTFLVdraKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSS-FPAVKPLWLNNFALTAGGI 560
Cdd:cd17319 185 ALGYFGINYALYGLLTWLP-TYLK---QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAV 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578 561 ATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAA 640
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAA 340

                       170
                ....*....|....
gi 24653578 641 FYFAGGLILLSAFL 654
Cdd:cd17319 341 FLFLAAVALLAALL 354
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 82-219 8.71e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.05  E-value: 8.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  82 GVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAIcFGLSYF----ATSVEYLFLIYGVLGGIGFCMV 157
Cdd:cd17369 260 GVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAAL-FAFPFFwlldTGSTWLIVLAAVVVLGVLHGMM 338

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653578 158 YIPAVVIIGFYFEKwRALATGVAM---CGSGVGTFvFAPLTKILLKSGWRYTLAIQGIIVLSCAL 219
Cdd:cd17369 339 YGPQAAFLAELFPT-RVRYTGASLgyqLGAILGGG-FAPLIATALVAATGSWWPVALYLAALAVI 401
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 86-225 9.31e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.73  E-value: 9.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653578  86 AYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVeYLFLIYGVLGGIGFCMVYiPAV-VI 164
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSP-WMLLLAAVLYGLGFGLLF-PALqAL 304

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653578 165 IGFYFEKWR---ALAT---GVAMcGSGVGTFVFAPLTKILlksGWRYTLAIQGIIVLSCALFGLAFR 225
Cdd:cd17489 305 AVDLVPPHRrgaANGTffiFFDL-GIGLGGLLLGLVAELF---GYRAMFLLAAVVVLLALVLYIFLL 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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