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Conserved domains on  [gi|161077085|ref|NP_725419|]
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knot, isoform B [Drosophila melanogaster]

Protein Classification

SGNH/GDSL hydrolase family protein( domain architecture ID 10878102)

SGNH/GDSL hydrolase family protein is a hydrolytic enzyme such as an esterase or lipase; may have multifunctional properties including broad substrate specificity and regiospecificity; also contains one or more N-terminal IPT/TIG domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 52-263 6.39e-170

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


:

Pssm-ID: 212156  Cd Length: 212  Bit Score: 480.39  E-value: 6.39e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  52 WAMQPVVDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLL 131
Cdd:cd11606    1 GVTDPSAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 132 YANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCN 211
Cdd:cd11606   81 YSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 161077085 212 QNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRL 263
Cdd:cd11606  161 QNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 299-383 1.97e-56

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


:

Pssm-ID: 238580  Cd Length: 85  Bit Score: 184.39  E-value: 1.97e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 299 PCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGR 378
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 161077085 379 FVYVS 383
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 385-428 8.67e-26

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


:

Pssm-ID: 406751  Cd Length: 44  Bit Score: 99.48  E-value: 8.67e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 161077085  385 LNEPTIDYGFQRLQKLIPRHPGDPEKLQKEIILKRAADLVEALY 428
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
 
Name Accession Description Interval E-value
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 52-263 6.39e-170

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 480.39  E-value: 6.39e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  52 WAMQPVVDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLL 131
Cdd:cd11606    1 GVTDPSAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 132 YANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCN 211
Cdd:cd11606   81 YSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 161077085 212 QNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRL 263
Cdd:cd11606  161 QNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
57-263 2.04e-157

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 449.29  E-value: 2.04e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085   57 VVDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGA 136
Cdd:pfam16422  21 VAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPEDEKTNNGIHYRLQLLYSNGI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  137 RQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLK 216
Cdd:pfam16422 101 RTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFMKCNQNCLK 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 161077085  217 NAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRL 263
Cdd:pfam16422 181 NAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 299-383 1.97e-56

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 184.39  E-value: 1.97e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 299 PCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGR 378
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 161077085 379 FVYVS 383
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 385-428 8.67e-26

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 99.48  E-value: 8.67e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 161077085  385 LNEPTIDYGFQRLQKLIPRHPGDPEKLQKEIILKRAADLVEALY 428
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 299-381 1.83e-15

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  299 PCIKAISPSEGWTTGGATVIIVGDNF---FDGLQVVFGTMLVWSELITSHAIRVQTPPrHIPGVVEVTLSYKSKQFCkGS 375
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGIS-SS 78


                  ....*.
gi 161077085  376 PGRFVY 381
Cdd:pfam01833  79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
299-382 6.79e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085   299 PCIKAISPSEGWTTGGATVIIVGDNFFDGlQVVFGTMLVWSELIT-----SHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 371
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 161077085   372 cKGSPGRFVYV 382
Cdd:smart00429  81 -PSSPQPFTYV 90
HLH smart00353
helix loop helix domain;
390-433 1.95e-04

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 39.51  E-value: 1.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 161077085   390 IDYGFQRLQKLIPRHPGDpEKLQKEIILKRAADLVEALYSMPRS 433
Cdd:smart00353  11 INEAFDELRSLLPTLPKN-KKLSKAEILRLAIEYIKSLQEELQK 53
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 390-427 1.58e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 36.91  E-value: 1.58e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 161077085 390 IDYGFQRLQKLIPRHPGdpEKLQKEIILKRAADLVEAL 427
Cdd:cd11419   19 INAGFQSLRTLLPHCDG--EKLSKAAILQQTAEYIFSL 54
 
Name Accession Description Interval E-value
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 52-263 6.39e-170

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 480.39  E-value: 6.39e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  52 WAMQPVVDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLL 131
Cdd:cd11606    1 GVTDPSAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 132 YANGARQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCN 211
Cdd:cd11606   81 YSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 161077085 212 QNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRL 263
Cdd:cd11606  161 QNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
57-263 2.04e-157

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 449.29  E-value: 2.04e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085   57 VVDQSNLGIGRAHFEKQPPSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGA 136
Cdd:pfam16422  21 VAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPEDEKTNNGIHYRLQLLYSNGI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  137 RQEQDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLK 216
Cdd:pfam16422 101 RTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFMKCNQNCLK 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 161077085  217 NAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRL 263
Cdd:pfam16422 181 NAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 299-383 1.97e-56

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 184.39  E-value: 1.97e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 299 PCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTMLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGR 378
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 161077085 379 FVYVS 383
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 385-428 8.67e-26

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 99.48  E-value: 8.67e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 161077085  385 LNEPTIDYGFQRLQKLIPRHPGDPEKLQKEIILKRAADLVEALY 428
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 299-381 1.83e-15

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085  299 PCIKAISPSEGWTTGGATVIIVGDNF---FDGLQVVFGTMLVWSELITSHAIRVQTPPrHIPGVVEVTLSYKSKQFCkGS 375
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGIS-SS 78


                  ....*.
gi 161077085  376 PGRFVY 381
Cdd:pfam01833  79 PLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 299-383 1.35e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 63.63  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 299 PCIKAISPSEGWTTGGATVIIVGDNFFDG--LQVVFGTMLVWSEL-ITSHAIRVQTPPRHI--PGVVEVTLSYKSkQFCK 373
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLsVSSTAIVCTTPPYANpgPGPVEVTVDRGN-GGIT 79

                         90
                 ....*....|
gi 161077085 374 GSPGRFVYVS 383
Cdd:cd00102   80 SSPLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
299-382 6.79e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085   299 PCIKAISPSEGWTTGGATVIIVGDNFFDGlQVVFGTMLVWSELIT-----SHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 371
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 161077085   372 cKGSPGRFVYV 382
Cdd:smart00429  81 -PSSPQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 299-382 1.34e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 40.90  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077085 299 PCIKAISPSEGWTTGGATVIIVGDNF---FDGLQVVFGTMLVWSELITSHAIRVQTPPRHIP--GVVEVTLSYKSKQFCK 373
Cdd:cd00603    1 PVITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgeGPVEVTVDGANVSARV 80


                 ....*....
gi 161077085 374 GSPGRFVYV 382
Cdd:cd00603   81 LSNTTFTYV 89
HLH smart00353
helix loop helix domain;
390-433 1.95e-04

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 39.51  E-value: 1.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 161077085   390 IDYGFQRLQKLIPRHPGDpEKLQKEIILKRAADLVEALYSMPRS 433
Cdd:smart00353  11 INEAFDELRSLLPTLPKN-KKLSKAEILRLAIEYIKSLQEELQK 53
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 390-427 1.58e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 36.91  E-value: 1.58e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 161077085 390 IDYGFQRLQKLIPRHPGdpEKLQKEIILKRAADLVEAL 427
Cdd:cd11419   19 INAGFQSLRTLLPHCDG--EKLSKAAILQQTAEYIFSL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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