NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24653962|ref|NP_725504|]
View 

cytochrome c oxidase subunit 6A-like [Drosophila melanogaster]

Protein Classification

cytochrome c oxidase subunit VIa family protein( domain architecture ID 10097106)

cytochrome c oxidase subunit VIa (COXVIa) family protein such as yeast cytochrome c oxidase polypeptide VIa (also known as Cox13p and Cox6ap) which is a component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_VIa cd00925
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 14-87 2.81e-39

Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.


:

Pssm-ID: 238465 [Multi-domain]  Cd Length: 86  Bit Score: 125.18  E-value: 2.81e-39
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653962 14 ANTAGLWKRVTFLLALPAIVLCAANAFTGHKHV---EREPFAKYEYLRRRTKRFPWGDGNRSLFHNAEVNALPEGYE 87
Cdd:cd00925 10 AGTSELWKKISFYVALPAVALCMLNAYLKHKEHeehERPEFVEYEHLNIRTKPFPWGDGNKTLFHNPHVNALPTGYE 86
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIa cd00925
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 14-87 2.81e-39

Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.


Pssm-ID: 238465 [Multi-domain]  Cd Length: 86  Bit Score: 125.18  E-value: 2.81e-39
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653962 14 ANTAGLWKRVTFLLALPAIVLCAANAFTGHKHV---EREPFAKYEYLRRRTKRFPWGDGNRSLFHNAEVNALPEGYE 87
Cdd:cd00925 10 AGTSELWKKISFYVALPAVALCMLNAYLKHKEHeehERPEFVEYEHLNIRTKPFPWGDGNKTLFHNPHVNALPTGYE 86
COX6A pfam02046
Cytochrome c oxidase subunit VIa;
14-80 2.97e-17

Cytochrome c oxidase subunit VIa;


Pssm-ID: 426579 [Multi-domain]  Cd Length: 112  Bit Score: 70.42  E-value: 2.97e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653962    14 ANTAGLWKRVTFLLALPAIVLCAANAF---TGH-------KHVEREPFakYEYLRRRTKRFPWGDGNRSLFHNAEVN 80
Cdd:pfam02046  35 AGTTDLWRKISYYVAIPALILAGINAYnleNEHwehwehlPPLEERTE--YPYQNIRTKNFFWGDGDKTLFWNDKVN 109
PLN02595 PLN02595
cytochrome c oxidase subunit VI protein
 10-78 9.34e-05

cytochrome c oxidase subunit VI protein


Pssm-ID: 178205  Cd Length: 102  Bit Score: 37.88  E-value: 9.34e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653962   10 GNMPANTAGLWKRVTFLLALPAIVLCAANAFTGHKHVEREPfaKYEYLRRRTKRFPWG-DGNRSLFHNAE 78
Cdd:PLN02595  34 GHDDAYEAAKWEKITYLGIASCTALAVYVLSKGHHHGEDPP--AYPYMHIRNKEFPWGpDGLFEVKHNKE 101
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIa cd00925
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 14-87 2.81e-39

Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.


Pssm-ID: 238465 [Multi-domain]  Cd Length: 86  Bit Score: 125.18  E-value: 2.81e-39
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653962 14 ANTAGLWKRVTFLLALPAIVLCAANAFTGHKHV---EREPFAKYEYLRRRTKRFPWGDGNRSLFHNAEVNALPEGYE 87
Cdd:cd00925 10 AGTSELWKKISFYVALPAVALCMLNAYLKHKEHeehERPEFVEYEHLNIRTKPFPWGDGNKTLFHNPHVNALPTGYE 86
COX6A pfam02046
Cytochrome c oxidase subunit VIa;
14-80 2.97e-17

Cytochrome c oxidase subunit VIa;


Pssm-ID: 426579 [Multi-domain]  Cd Length: 112  Bit Score: 70.42  E-value: 2.97e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653962    14 ANTAGLWKRVTFLLALPAIVLCAANAF---TGH-------KHVEREPFakYEYLRRRTKRFPWGDGNRSLFHNAEVN 80
Cdd:pfam02046  35 AGTTDLWRKISYYVAIPALILAGINAYnleNEHwehwehlPPLEERTE--YPYQNIRTKNFFWGDGDKTLFWNDKVN 109
PLN02595 PLN02595
cytochrome c oxidase subunit VI protein
 10-78 9.34e-05

cytochrome c oxidase subunit VI protein


Pssm-ID: 178205  Cd Length: 102  Bit Score: 37.88  E-value: 9.34e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653962   10 GNMPANTAGLWKRVTFLLALPAIVLCAANAFTGHKHVEREPfaKYEYLRRRTKRFPWG-DGNRSLFHNAE 78
Cdd:PLN02595  34 GHDDAYEAAKWEKITYLGIASCTALAVYVLSKGHHHGEDPP--AYPYMHIRNKEFPWGpDGLFEVKHNKE 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH