|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
41-501 |
0e+00 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 596.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 41 YFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEaEEYDDECGDRDIPIDDSQDGEFAWSSALQGYILSSFFYGYV 120
Cdd:TIGR00894 12 YFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKE-NSTDLACLSAENELDNIKNPNFKWSGALQGLILSSHFYGQI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 121 ITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWgLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMG 200
Cdd:TIGR00894 91 IIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIAL-VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 201 AAVYAGAQFGTIISMPLSGLLAEYgfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLWGTDVV 280
Cdd:TIGR00894 170 GMSTSGFQLGTFIFLPISGWLCES--WGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 281 KSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISS 360
Cdd:TIGR00894 248 TRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSS 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 361 KRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANL 440
Cdd:TIGR00894 328 KTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFI 407
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654215 441 AGLLAPIAAGHLISDPSKpmmGQWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQ 501
Cdd:TIGR00894 408 GGLIASTLAGNILSQDSK---NVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
44-486 |
0e+00 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 530.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 44 TFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDdecgdrdIPIDDSQDGEFAWSSALQGYILSSFFYGYVITQ 123
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTD-------KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 124 IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGgVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAV 203
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGG-YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 204 YAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyindslwgtdvvksp 283
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCES---LGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 284 pipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRF 363
Cdd:cd17318 199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 364 SHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGL 443
Cdd:cd17318 269 STTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGI 348
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 24654215 444 LAPIAAGHLISDpsKPMMGQWQIVFFIAAFVYIICGTFYNIFG 486
Cdd:cd17318 349 ISPLIVGAIVKN--DQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
45-486 |
5.81e-115 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 345.61 E-value: 5.81e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 45 FMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQDGE-FAWSSALQGYILSSFFYGYVITQ 123
Cdd:cd17381 3 LLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKkYDWDAETQGWILGSFFYGYIITQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 124 IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWgLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAV 203
Cdd:cd17381 83 IPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGY-LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTIS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 204 YAGAQFGTIISMPLSGLLAEYGfdgGWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyindslwgtdvvksp 283
Cdd:cd17381 162 YAGAQLGTVVSLPLSGLICYYL---DWTYVFYIFGAVGLLWFFLWIWLV------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 284 pipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRF 363
Cdd:cd17381 208 ----------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 364 SHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGL 443
Cdd:cd17381 278 STVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGM 357
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 24654215 444 LAPIAAGHLISDPSkpmMGQWQIVFFIAAFVYIICGTFYNIFG 486
Cdd:cd17381 358 VGPVIAKSLTHNNT---VEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-486 |
5.16e-92 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 285.22 E-value: 5.16e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 44 TFMLFLGMANAYVMRTNMSVAIVAMVNhtaiksgeaeeyddecgdrdipiddsqdgEFAWSSALQGYILSSFFYGYVITQ 123
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAK-----------------------------EFGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 124 IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAV 203
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY-SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 204 YAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyindslwgtdvvksp 283
Cdd:cd17380 131 TAGSYLGTLLGGLIGPLLLEY---YGWPSVFYFFGLLGLLWALVWLIYL------------------------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 284 pipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLrFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIsSKRF 363
Cdd:cd17380 177 ----------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLI-SRGW 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 364 SHTATRKLINSIGQYGPGVALIAASYTgCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGL 443
Cdd:cd17380 245 TVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGI 323
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 24654215 444 LAPIAAGHLISDPskpmmGQWQIVFFIAAFVYIICGTFYNIFG 486
Cdd:cd17380 324 VGVYLTGYILEAT-----GSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
45-486 |
1.52e-83 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 264.20 E-value: 1.52e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 45 FMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYddecgdrdipiddsQDGEFAWSSALQGYILSSFFYGYVITQI 124
Cdd:cd17382 2 IMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIV--------------HKAEFNWTPETVGLIESSFFWGYLVTQI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 125 PFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWgLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVY 204
Cdd:cd17382 68 PGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGC-VIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAF 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 205 AGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIaFLIFVhedpsshptiderekkyindslwgtdvvkspp 284
Cdd:cd17382 147 CGSYAGAVVGMPLSGILVQY---VGWSSPFYVYGVFGIIWYM-FWMLV-------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 285 ipfkaiikSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFS 364
Cdd:cd17382 191 --------SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILS 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 365 HTATRKLINSIGQYGPGVALIAASYTGcDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLL 444
Cdd:cd17382 263 TTAVRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMV 341
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 24654215 445 APIAAGHLISDPSKpmmGQWQIVFFIAAFVYIICGTFYNIFG 486
Cdd:cd17382 342 CPVIVGALTKHKTR---EEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-482 |
7.79e-51 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 177.76 E-value: 7.79e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVnhtaiksgeaeeyddecgdrdipiddsqdGEFAWSSALQGYILSSFFYGY 119
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIM-----------------------------KDLGLSPTQYGLIASAFFLGY 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 120 VITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRM 199
Cdd:cd17319 52 ALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA---TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 200 GAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEdpsshptiderekkyindslwgtdv 279
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLL---FGWRWAFIIEGLLGLLLAVLWWFYLRQ------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 280 vksppipfkaiikslpFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIS 359
Cdd:cd17319 181 ----------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 360 SKRFSHTATRKLINSIGqygpgvalIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPR-FAGFLMSITNCSA 438
Cdd:cd17319 245 GARRLVIIIGLLLAAVG--------LLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 24654215 439 NLAGLLAPIAAGHLISDpskpmMGQWQIVFFIAAFVYIICGTFY 482
Cdd:cd17319 317 NLGGFVAPLLIGYLVDA-----TGSYTAAFLFLAAVALLAALLV 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-482 |
9.25e-44 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 158.88 E-value: 9.25e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNhtaiksgeaeeyddecgdrdipiddsqdgEFAWSSALQGYILSSFFYGY 119
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQA-----------------------------DLGLSAAQLGLLASAFFLGY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 120 VITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRM 199
Cdd:COG2271 59 ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 200 GAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIaflifvhedpsshptiderekkyindslwgtdv 279
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAA---FGWRAAFLILGLPGLLLAL--------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 280 vksppipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIS 359
Cdd:COG2271 180 --------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 360 SkrfshtatRKLINSIGQYGPGVALIAASYTGcDRALTLAILTIGVGLNGGIYSGFKINHLDLTP-RFAGFLMSITNCSA 438
Cdd:COG2271 246 R--------RKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 24654215 439 NLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICGTFY 482
Cdd:COG2271 317 FLGGALGPLLVGYLLD------ATGYQAAFLLLAALALLAALLA 354
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
100-482 |
5.11e-39 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 146.42 E-value: 5.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPI 179
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP---SFWLLLLGRFLLGLGSGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 259
Cdd:cd06174 102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS-LGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTIDEREKKyindslwgtdvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 339
Cdd:cd06174 181 RAKNEEASS------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 340 YLAMWLFSMFISVVADWMISskrfshtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINH 419
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 420 LDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMGQWQIVFFIAAFVYIICGTFY 482
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA-----ATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
100-446 |
1.44e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 133.31 E-value: 1.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPI 179
Cdd:pfam07690 26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS---SLWLLLVLRVLQGLGAGAL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhEDPSSH 259
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---FGWRAAFLILAILSLLAAVLLLLPR-PPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTIDEREKKYINDSLWGtdvvksppipfkaIIKSLPFYAILFAHMGHNYGYETLMTELPTYMkQVLRFSLKSNGLLSSLP 339
Cdd:pfam07690 179 RPKPAEEARLSLIVAWK-------------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 340 YLAMWLFSMFISVVADWMisskrfsHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLnGGIYSGFKINH 419
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRL-------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF-GLVFPALNALV 316
|
330 340
....*....|....*....|....*...
gi 24654215 420 LDLTP-RFAGFLMSITNCSANLAGLLAP 446
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
100-478 |
1.09e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 114.59 E-value: 1.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:COG2223 34 EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA---VSYWLLLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEygfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 259
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA---AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTiderekkyindslwgtdVVKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 339
Cdd:COG2223 188 AA-----------------AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 340 YLAMWLFSMFISVVADwmisskRFShtatRKLINSIGQYGPGVALIAASYTGCD-RALTLAILTIGVGLNGGIYSGFKIN 418
Cdd:COG2223 251 ALLGALGRPLGGWLSD------RIG----GRRVLLIVFALMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 419 HLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMGQWQIVFFIAAFVYIIC 478
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD-----ATGSYTAAFLVFAVLALVA 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-445 |
9.27e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.22 E-value: 9.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:COG2814 39 DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA---PSLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhedPSSH 259
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL---FGWRWVFLVNAVLALLALLLLLRLL---PESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTIDEREKKyindslwgtdvvksppiPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 339
Cdd:COG2814 190 PAARARLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 340 YLAMWLFSMFISVVADWmISSKRFshtatrkLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINH 419
Cdd:COG2814 253 GLGGVLGALLAGRLADR-FGRRRL-------LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|....*.
gi 24654215 420 LDltPRFAGFLMSITNCSANLAGLLA 445
Cdd:COG2814 325 AP--PEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
104-485 |
5.06e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.51 E-value: 5.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPIVPCT 183
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS---YWQLLLARFLQGLASAAVWPAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTID 263
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA---LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 264 EREKKyindslwgtdvvksPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAM 343
Cdd:cd17325 183 VSAAR--------------LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 344 WLFSMFISVVADWMisskrfshtaTRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLngGIYSGFKINHL-DL 422
Cdd:cd17325 249 ALSQPPAGKLSDRI----------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL--GLVFPATLALLaDI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654215 423 TPRFA-GFLMSITNCSANLAGLLAPIAAGHLISDpskpmmGQWQIVFFIAAFVYIICGTFYNIF 485
Cdd:cd17325 317 VPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDA------FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
100-364 |
1.43e-16 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 81.65 E-value: 1.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSV----FAFlvpvaarGGGVWGLCAVRFIQGLG 175
Cdd:TIGR00881 24 EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIvnlfFGF-------STSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 176 EGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLsgLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHED 255
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPL--VLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 256 PSShPTIDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAIL-------FAHMGHNYGYETLmteLPTYMKQVLRFS 328
Cdd:TIGR00881 175 PQS-CGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLwyislgyVFVYVVRTGILDW---SPLYLTQEKGFS 250
|
250 260 270
....*....|....*....|....*....|....*.
gi 24654215 329 LKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFS 364
Cdd:TIGR00881 251 KEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGP 286
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-270 |
1.12e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 78.83 E-value: 1.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 110 YILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAK 189
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL---TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 190 WIPPNERSRMGAAVYAGAQFGTIismpLSGLLAeYGF---DG-----GWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPT 261
Cdd:cd17327 122 WYKREEQAKRIAFFYAAAGLGSI----FGGLLA-YGVfkiLGvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWF 196
|
....*....
gi 24654215 262 IDEREKKYI 270
Cdd:cd17327 197 LTEEEKELA 205
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
100-254 |
2.34e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.77 E-value: 2.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:COG0477 43 DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA---PSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVwSIAFLIFVHE 254
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA---LGWRWIFLINAPLGLL-ALVLRLRLPE 190
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
104-482 |
4.91e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 76.89 E-value: 4.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 183
Cdd:cd17328 32 DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFA---PNFWQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHptID 263
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQA--TGGWRWAFRVTGVLGVLLAILLLLFVREPPRGA--AE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 264 EREKKYINDSLWGTDVvksppipfKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSslpyLAM 343
Cdd:cd17328 185 GGVMAKSTATSFLADL--------KALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVG----LIF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 344 WLFSMFISVVADWM--ISSKRFSHT--ATRKLINSIGQYGpGVALIAASYTGCDRALTLAILTIGVG-LNGGIYSG--FK 416
Cdd:cd17328 253 GAITCIAGVLGVLLggILADRLRRKtpRADPLVCAVGLLA-AAPFLFLALVLALSNLLLAWVLLFLGeFLLSLNWApvFA 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654215 417 INHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISD-----PSKPMMG--QWQIVFFIAAFVY-IICGTFY 482
Cdd:cd17328 332 ILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDllrqnKDSPLAEaaSLQYALLLCSFVLvLGGFFFL 405
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
100-482 |
1.07e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.68 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPI 179
Cdd:cd17474 28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS---FALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSR-MGaaVYAGA-QFGTIISMPLSGLLAEYGfdggWPSIFYVFGIVGTVWSIAFLIFVHEDPS 257
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKaMG--LYEAAlGLGIAVGPLLGGLLAAIS----WRYPFFLLAALIPVAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 258 SHPTIDEREKKYindslwgtdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSS 337
Cdd:cd17474 179 KAKSSSATKLRD-----------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 338 LPYLAMWLFSMFISvvadwMISSKRFSHTATRKLINSIgqYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKI 417
Cdd:cd17474 242 GWSVLLALGSLFVG-----RLLKKRFGARRILVIGLLL--YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654215 418 NHLDLTPRfaGFLMSITNCSANLAGLLAPIAAGHLIsdpskpMMGQWQIVFFIAAFVYIICGTFY 482
Cdd:cd17474 315 ELAPEEER--GTASSLYNFVRFLGQAVGPLLFGLLL------EIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
100-477 |
5.50e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 5.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA---PSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 259
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL---LGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTIDEREKKYIndslwgtDVVKSPPIPFKAIIkslpfYAILFAhmghnyGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 339
Cdd:cd17324 182 PGSLGLLSSLL-------LLLRNPRLRLAYLI-----TFLLFG------GFFALYTYLAPFLTDVPGFSSSAIIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 340 YLAMWLFSMFISVVADWmisskrfsHTATRKLINSIGQYGPGVALIAASYTGcdRALTLAILTIGVGlNGGIYSGFKINH 419
Cdd:cd17324 244 GVAGVVGSPLAGRLADR--------GGRRALLIALLLLAAALLLLTLLGPSP--LLLLVGLVLWGLG-FFAAHSALQTRV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 24654215 420 LDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYII 477
Cdd:cd17324 313 LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
100-479 |
9.45e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 73.11 E-value: 9.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPI 179
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL---CGFAQNYWQLLILRALAGLGFGGE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDG-GWPSIFYvFGIVGTVWSIAFLIFVHEDPSS 258
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiAWRVLFL-LGALPALLVLFIRRFVKEPPQW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 259 hptideREKKYINDSlwgtdvvkSPPIPFKAIIKSLPF-----YAILFAhMGHNYGYETLMTELPTYMKQVLRFSLKSNG 333
Cdd:cd17371 184 ------QAARAARRH--------FADRPSLRELFSPPLlrttlLASLLA-TGALGGYYGITTWLPSYLTGERGLSFEGSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 334 LlsslpYLAMWLFSMFISVVAdWMISSKRFShtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYS 413
Cdd:cd17371 249 G-----YLVVTILGGFLGYLA-GGFLADRIG----RRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654215 414 GFKINHLDLTP-RFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICG 479
Cdd:cd17371 319 GMGAYLTELFPtAVRATAQGFCYNVGRIIGALFPFLVGFLAT------SGSLGTAIAVFAAVYYIAG 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
40-481 |
1.83e-13 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 71.92 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNhtaiksgeaeeyddecgdrDIPIDDSQdgefawssalQGYILSSFFYGY 119
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE-------------------EIGLSKDD----------LGIIGSAFLIAY 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 120 VITQIPFGILAKKYGSLRFLGYGML----INSVFAFLVpvaarggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNE 195
Cdd:cd17312 52 AVGKFISGFLSDRSNIRRFMSAGLLlsalANIFMGFST-------SLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 196 RSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPsshPTIderekkyindslw 275
Cdd:cd17312 125 RGTVYGIWSTSHNFGGILAPILAASLASY---YGWRAAFLVPGIVGLVVAIILFFFLRDSP---PYV------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 276 gtdvvksppipfkaIIKSLpfyAILFAhMGHNYGYETLmteLPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVAD 355
Cdd:cd17312 186 --------------WVLSL---AYAFV-YIVRYACLDW---GPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 356 wmissKRFShtATRKLINSIGQYGPGVALIAASYTGCDRALTLAILT-IGVGLNGGIYSGFKINHLDLTPRFA-GFLMSI 433
Cdd:cd17312 245 -----KLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFlIGFFVGGPINLIGGAAAQDIGRKEAaGTATGF 317
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 24654215 434 TNCSANLAGLLAPIAAGHLISDPSkpmmgqWQIVFFIAAFVYIICGTF 481
Cdd:cd17312 318 VGLFGYLGASLAGLPLGYIIDHYG------WSTVFYFLISAALLSVLL 359
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
40-349 |
1.43e-12 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 69.58 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVnhtaiksgeaEEYDdecgdrdipiddsqdgefaWSSALQGYILSSFFYGY 119
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLI----------EQYG-------------------LSKTEIGLIGSALSIAY 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 120 VITQIPFGILAKKYGSLRFLGYGM----LINSVFAFlvpVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNE 195
Cdd:cd17345 52 GLSKFVMGNLSDRSNPKRFLAIGLilsaIINILIGF---VPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKE 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 196 RSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH--PTIDEREKKYINDS 273
Cdd:cd17345 129 RGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 274 LWGTDVVK--SPPIPFKAII--KSLPFYAI--LFAHMGHnYGyetLMTELPTYMKQVLRFSLKSngllsslpylAMWLFS 347
Cdd:cd17345 209 DGEEEEQElsAWEIFVKYVLknKLLWYIAIanVFVYLVR-YG---ILDWAPTYLSEVKGFSKAQ----------AMWAFS 274
|
..
gi 24654215 348 MF 349
Cdd:cd17345 275 LF 276
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
100-252 |
2.21e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 2.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFV 252
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
100-453 |
5.48e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.26 E-value: 5.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPI 179
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL---MALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERS-RMG---AAVYAGAQFGTIISMPLSGLLaeygfdgGWPSIFYVFGIVGTVWSIAFLIFVHED 255
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGlAMGirqTGVPLGGALAAALLPPLALHY-------GWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 256 PsshptiDEREKKYINDSLWGTdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLL 335
Cdd:cd17475 175 P------AASAATESASTLLRS---------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 336 SSLPYLAMWLFSMFISVVADWMISSKRfshtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLnggiySGF 415
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVFGGRR------RPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGL-----FAI 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 24654215 416 KINHLDLT-------PRFAGFLMSITNCSANLAGLLAPIAAGHLI 453
Cdd:cd17475 309 GWNGLYLTlvaesagPEQAGTALGLANTINFIGIAIGPPLFGLLV 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
126-481 |
1.95e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 65.67 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 126 FGILAKKYGSLRFLGYGMLINSVF---AFLVPvaarggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAA 202
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGgvaGLFLD------SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 203 VYAGAQFGTIISMPLSGLLAEYgfdgGWPSIFYVFGIVGTVWsIAFLIFVHEDPSSHPTIDEREKkyindslwgtdvVKS 282
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAEI----GWRAPFLVYLLALPVL-ILVLLFLPEPARKSKSAASPGA------------ATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 283 PPIPFKAIiksLPFYAILFAHMGHNYgyeTLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVadwmisSKR 362
Cdd:cd17473 192 AALPWKRV---LPIYFLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL------KRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 363 FSHTATrklinsigqYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYsGF---KINHL---DLTPRFAGFLMSITNC 436
Cdd:cd17473 260 LGKRRL---------LAIGFALMALGFLLLALASGLWVVLLGAILAGLGF-GLllpTLNSWamsLVPPELRGRAMGIVTS 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 24654215 437 SANLAGLLAPIAAGHLISDPSkPMMGQWQIVFFIAAFVYIICGTF 481
Cdd:cd17473 330 AFFLGQFLSPLVLGPLVNLTG-GLSGAFLILGVLALVLAIVLLLL 373
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
100-453 |
1.98e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.84 E-value: 1.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPI 179
Cdd:TIGR00895 46 EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL---CALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeyGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDP--- 256
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL---IPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIdfl 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 257 -SSHPTIDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAILFAHMGHN------------YGYETLMTELPTYMKQ 323
Cdd:TIGR00895 200 vSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARItvllwllyfmllVGVYFLTNWLPKLMVE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 324 vLRFSLKSNGLLSSLPYLAMWLFSMFISVVADwmisskRFShtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTI 403
Cdd:TIGR00895 280 -LGFSLSLAATGGALFNFGGVIGSIIFGWLAD------RLG----PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIA 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 24654215 404 GVGLNGGiYSGFkinhLDLTPRF---------AGFLMSItncsANLAGLLAPIAAGHLI 453
Cdd:TIGR00895 349 GFFVNGG-QSGL----YALMALFyptairatgVGWAIGI----GRLGAIIGPILAGYLL 398
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
103-485 |
4.81e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 4.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 103 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPC 182
Cdd:cd17329 32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA---HSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 183 THAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDggwpsifYVFGIVGTVWSIAFLIFVHEDPSSHPTI 262
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR-------LLFLAAAVLFLLAALVLLFLLPETRPKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 263 DEREKkyindslwgtdvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLA 342
Cdd:cd17329 182 RAAEK-------------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 343 MWLFSMFIsvvadwmisSKRFSHTATRKLInSIG----QYGPGVALIAASYTGCdrALTLAILTIGVGLNGGIYSGFkIN 418
Cdd:cd17329 249 IVLLQFPV---------ARLVERFRLRKIL-MIGillfAIGFAVLAFANTLAVL--ILAMIVLTLGEMLVFPAVQTL-VA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654215 419 HLdLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICGTFYNIF 485
Cdd:cd17329 316 AL-APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD------LLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
120-450 |
1.39e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.38 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 120 VITQIPFGILA----KKYGSLR-FLGYGMLINSVFA---FLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWI 191
Cdd:COG2211 60 AITDPLIGALSdrtrTRWGRRRpWILIGAIPLALSFvllFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 192 P-PNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDG---GWPSIFYVFGIVGTVWSIAFLIFVHEDPSShptidEREK 267
Cdd:COG2211 140 PdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalGYRLTALIFAVLGLLAFLLTFFGTKERPVP-----EEEK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 268 KYINDSlwgtdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLsslpyLAMWLFS 347
Cdd:COG2211 215 VSLKES-------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLL-----LALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 348 MFISVVAdWMISSKRFShtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGF---------KIN 418
Cdd:COG2211 277 ALLGAPL-WPRLAKRFG----KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLpwamladvvDYD 351
|
330 340 350
....*....|....*....|....*....|..
gi 24654215 419 HLDLTPRFAGFLMSITNCSANLAGLLAPIAAG 450
Cdd:COG2211 352 EWKTGRRREGLYFGIFTFAIKLGQALAGALAG 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
96-239 |
3.38e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.85 E-value: 3.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 96 SQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLG 175
Cdd:cd17316 26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIG 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654215 176 EGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAE-YGFDGGWPSIFYVFGI 239
Cdd:cd17316 103 IGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPlLSGDWGWRILFLIGAL 167
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
100-482 |
3.53e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.79 E-value: 3.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA---PSYPLLLLALFLLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGA--AVYAgaqFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIfvhedpS 257
Cdd:COG0738 114 DVAANPYVAALGPETAASRLNLlhAFFS---LGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLR------S 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 258 SHPTIDEREKKyindslwgtdvVKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKsnglLSS 337
Cdd:COG0738 185 KLPEIEEEEEE-----------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA----TAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 338 LPYLAMWLFSMFISVVADWMIssKRFSHtatRKLInSIGQYGPGVALIAASYTGCDRALTLAILTIGVGlNGGIYSGfkI 417
Cdd:COG0738 250 LGLSLFWGGMTIGRFLGGFLL--KRFGP---VRLL-RLSALLAAVGLLLALLAPGPWLALIGLALVGLG-LSLMFPT--I 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654215 418 NHL--DLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMG-QWQIVFFIAAFVYIICGTFY 482
Cdd:COG0738 321 FSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAD-----AFGlRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
100-241 |
5.25e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.06 E-value: 5.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:cd17365 28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA---QSVLQLALLRFLTGLGLGAA 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIIsmplSGLLAEYGFDG-GWPSIFYVFGIVG 241
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAAL----GGFLAAALIPAfGWRSVFLLGGVPP 163
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
104-356 |
5.26e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 5.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 183
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA---TSVALLLVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERSR----MGAAVYAGAQFGTIISMPLSGLLaeygfdgGWPSIFYVFGIVGTVwSIAFLIFVHEDPSSH 259
Cdd:cd17489 106 ATLVADIIPPSRRGEgigyYGLATTLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALL-ALLLVFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTIDEREKKYINDSLWGtdvvksppipfkaiiKSLPFYAILF-AHMghnyGYETLMTELPTYMKQVLrfsLKSNGLLSSL 338
Cdd:cd17489 178 AEEAEAGTRAFRRLVEK---------------KVLPPALILFlASI----AYGAISTFLPLYAAERG---ISNAGLFFTV 235
|
250
....*....|....*...
gi 24654215 339 PYLAMWLFSMFISVVADW 356
Cdd:cd17489 236 YAIALLLSRPFSGKLSDR 253
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
104-250 |
1.74e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.49 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 183
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA---PSLAFLIAARALQGIGAAAIMPAS 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYV---FGIVGTVWSIAFLI 250
Cdd:cd17321 106 LALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL---FGWRWIFLInvpIGLVALLLARTFSG 172
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
100-354 |
2.83e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.13 E-value: 2.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLIN---SVFAFLVPvaarggGVWGLCAVRFIQGLGE 176
Cdd:cd17320 28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFilaSLLCALAS------SIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 177 GPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEdp 256
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF---FGWRAIFVFLALLGLLLLLLVLLFLPE-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 257 sshpTIDEREKKYINDSLWGTdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLS 336
Cdd:cd17320 177 ----TLPEEKRKPLLSSLLRA---------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLF 243
|
250
....*....|....*...
gi 24654215 337 SLPYLAMWLFSMFISVVA 354
Cdd:cd17320 244 ALNAIALILGSLLNGRLV 261
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
104-482 |
4.09e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 55.31 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGG--VWGLCAVRFIQGLGEGPIVP 181
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlsLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 182 CTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeYGFDGgwPSIFYVFGIVGTVWSIAFLIFVHEDPssHPT 261
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--VALLG--PGGAFAINALSFLLSALLLLFIRRPP--PAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 262 IDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAILFAhmghnygyetLMTELPTYMKQVLRFSLKSNGLLSSLPYL 341
Cdd:cd06173 186 PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGA----------LTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 342 AMWLFSMFISVVadwmisSKRFSHtatRKLInsigqyGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKIN--- 418
Cdd:cd06173 256 GALLGALLLGRL------SKRRRR---GRLL------LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPlnt 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24654215 419 --HLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLIsdpskPMMGqWQIVFFIAAFVYIICGTFY 482
Cdd:cd06173 321 llQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA-----DALG-LSAVFLLAGALLLLAALLL 380
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
104-265 |
4.32e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 4.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLInSVFAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCT 183
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL-AALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERS--RMGAAVYAGAQ-----FGTIISMPLSG-LLAEYGFDGGWP----------SIFYVFGIVGTVWS 245
Cdd:COG2211 341 WAMLADVVDYDEWKtgRRREGLYFGIFtfaikLGQALAGALAGlLLALFGYVAGAAqspsaltgirLLFFLLPAVLLLLA 420
|
170 180
....*....|....*....|
gi 24654215 246 IAFLIFVHEDPSSHPTIDER 265
Cdd:COG2211 421 ALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
104-354 |
5.23e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.91 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLInsVFAFLVpVAARGGGVWGLCAVRFIQGLgeGPIVPCT 183
Cdd:cd17472 30 TPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLL--FIAGSL-LAAYATSIYGLILGRALQGS--GAISSVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERSRmgAAVYAGAQFGT--IISMPLSGLLAE-YGFdggwPSIFYVFGIVGTVwSIAFLIFVHEDPSSHP 260
Cdd:cd17472 105 MALLADLTREENRTK--AMALIGASIGIafAISMVLGPLLAAhLGV----SGLFLITAILSLV-SLLILLFFVPDPPKIV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 261 TIDEREKKYindslwgtdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVlrFSLKSNGLLSSLPY 340
Cdd:cd17472 178 QISEKEKKK-----------------LKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQL--GGGKGQLWKVYLPA 238
|
250
....*....|....
gi 24654215 341 LAMWLFSMFISVVA 354
Cdd:cd17472 239 ILIGFILMVPFVIY 252
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
109-477 |
1.80e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 53.35 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 109 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCThAMLA 188
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS---RNLWLLFLARFLDGLTGGNVSVAQ-AYIA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 189 KWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLifvhedpsshptiderekk 268
Cdd:cd17330 113 DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 269 yindslwgtdvvksPPIPFkaiikslpfyaILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSM 348
Cdd:cd17330 174 --------------PPLRR-----------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 349 FIsvvadWMISSKRFShtaTRKLIN-SIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPR-- 425
Cdd:cd17330 229 LL-----IPRLAKRLG---ERKLLRlGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQgk 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 24654215 426 FAGFLMSITncsaNLAGLLAPIAAGHLISDPSKPMmgqwqiVFFIAAFVYII 477
Cdd:cd17330 301 AQGIIQSLQ----SLARIIGPLLAGPLYSFLGPGV------PFLLAAGLLLI 342
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
100-481 |
1.94e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.34 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 179
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA---PSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIpPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 259
Cdd:COG2807 124 NVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA---LGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTiderekkyindslwgtdvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQvLRFSLKSNGLLSSLP 339
Cdd:COG2807 200 AA-------------------APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 340 YLAMWLFSMFISVVADWMisskrfshtATRKLINSIgqygpGVALIAASYTGC----DRALTLAILTIGVGLnGGIYS-- 413
Cdd:COG2807 260 QLAGIPGSLLVPLLADRL---------GDRRPLLLL-----LGLLGLAGLLGLllapGSLPWLWAVLLGLGQ-GGLFPla 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24654215 414 -GFKINHLDlTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMGQWQIVFFIAAFVYIICGTF 481
Cdd:COG2807 325 lTLIGLRAR-TPAEAAALSGMAQSVGYLLAALGPLLVGALHD-----ATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
124-249 |
2.10e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.96 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 124 IPF-GILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAA 202
Cdd:cd17503 48 IPLsGWLADRFGTRRLFLTALALFTLGSLL---CGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGL 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 24654215 203 VYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYV---FGIVGtVWSIAFL 249
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDN---LSWRWIFYInlpIGILA-LLLAPLL 170
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-251 |
4.60e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 4.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 109 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLA 188
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 189 KWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIF 251
Cdd:cd06173 324 LRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA---LGLSAVFLLAGALLLLAALLLLLL 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
100-254 |
9.27e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 9.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLR--FLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEG 177
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALL---PSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654215 178 PIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHE 254
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
98-258 |
1.01e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 51.12 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 98 DGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGslrfLGYGMLINSVF----AFLVPVAARGGGVWGLCAVRFIQG 173
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFG----RKKSLLIANVLfvigAVLQGAAKGKWSVYQLIVGRVLVG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 174 LGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYvfgiVGTVWSIAFLIFVH 253
Cdd:pfam00083 114 IGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLG----LQLVPALLLIIGLL 189
|
....*
gi 24654215 254 EDPSS 258
Cdd:pfam00083 190 FLPES 194
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
100-240 |
2.28e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.96 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPI 179
Cdd:PRK11551 44 EFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWD---FPSLLVARLLTGVGLGGA 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEygfDGGWPSIFYVFGIV 240
Cdd:PRK11551 121 LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAG---DAAWRHIFYVGGVG 178
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
118-255 |
4.05e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.18 E-value: 4.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 118 GYVITQ----IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPP 193
Cdd:cd17476 41 SYSLTVgtfiLIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSP---NFIFFIICRALQGLGPAFLLPNAMALLGRTYPP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 194 NERSRMGAAVY-AGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHED 255
Cdd:cd17476 118 GPRKNIVFSLFgATAPLGFALGGVFGGLFAQL---AWWPWIFWFLAILAAIVAVAAIFWTSPS 177
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
109-283 |
4.50e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 48.87 E-value: 4.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 109 GYILSSFFYGYVITQIPFGILAKKYgSLRFLGYGMLINSVfafLVPVA-ARGGGVWGLCAVRFIQGLGEGPIVPCTHAML 187
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQI-SARWLFSSGLVLSG---LTTVAfSGSSSVWVFSILWFLNGLAQGLGWPPCAKIL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 188 AKWIPPNersrmgaavyagaQFGTI-----ISMPLSG----LLAEY-GFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPS 257
Cdd:cd17343 117 RKWFSPS-------------QFGTWwsvlsTSMNLAGslgpILATLlALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPS 183
|
170 180 190
....*....|....*....|....*....|....
gi 24654215 258 SH--PTIDEREKKY------INDSLWgTDVVKSP 283
Cdd:cd17343 184 DVglNNIEEEESKGkkkkspRGESTL-KELLLSP 216
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
100-249 |
4.82e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.96 E-value: 4.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWGLCAvrFIQGLGEGPI 179
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL--LLLGFGLGGL 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 180 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFdgGWPSIFYVFGIVGTVWSIAFL 249
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
299-504 |
8.33e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 299 ILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADwmisskRFShtatRKLINSIGQY 378
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD------RFG----RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 379 GPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSk 458
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 24654215 459 pmmgqWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQKPA 504
Cdd:pfam07690 150 -----WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
103-323 |
8.37e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.07 E-value: 8.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 103 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLinsVFAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPC 182
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLL---LTVLLLAAMALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 183 THAMLAKWIPPNERSRMGAAVYAGAQFGTIIsmplSGLLAEYGFDGG--WPSIFYVFGIVGTVWSIAFLIFVHEDPSSHP 260
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIAL----SGLLVPAGLGGGlsWRAGWLALALLSAVLLLLSFLLLRRGPSAPT 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 261 TiderekkyindslwgtdvvksPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQ 323
Cdd:cd06180 184 E---------------------ASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARE 225
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
100-243 |
1.20e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.57 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFY-GYVITQIpFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGeGP 178
Cdd:cd17504 25 EFGTSAAAVSWVLTAYLLvGAVSTPI-LGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN---LPVLIAGRALQGIG-GA 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24654215 179 IVPCTHAMLAKWIPPnERSRMGAAVYAG-AQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTV 243
Cdd:cd17504 100 VFPLAFALVREEFPP-ERVPVAQGILSAtFGIGAGIGLPLGGWIVQH---LGWRWIFWTAAPVAVL 161
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
100-240 |
3.37e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.03 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPF-GILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGP 178
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS---VPLLVLAAAILAFGTGI 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654215 179 IVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeYGFDGGWPSIFYVFGIV 240
Cdd:cd17330 281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPGVPFLLAAGLL 340
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
103-252 |
3.87e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.01 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 103 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAarGGGVWGLCAVRFIQGLGEGPIVPC 182
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV--PGLPLALLVLLFLWGGAAGPLYTL 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 183 THAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWpsiFYVFGIVgtvwSIAFLIFV 252
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGL---FLFLAAV----ALLFLLFL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
101-248 |
4.65e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.64 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 101 FAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAarGGGVWGLCAVRFIQGLGEGPIV 180
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGN 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654215 181 PCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeYGFDGGWPSIFYVFG---IVGTVWSIAF 248
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL--LDATGSYTAAFLVFAvlaLVALVLTLLL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-452 |
4.94e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 109 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggvWGLCAVR-FIQGLGEGPIVPCTHAML 187
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPS----IYLFVVLmFLAGLGAGILDTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 188 AKWIPPNERSRMgAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPsiFYVFGIVGTVWSIAFLIfvhedpsshPTIDEREK 267
Cdd:cd17333 110 GALFEESSATRL-NVLHGFFGLGALIGPLIATSLLTSELSWSWA--YLIIGLIYLLLAILILL---------TLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 268 KYINDSLWGTDvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMtelPTYMKQVLRFSLKSNGLLSSLpylamWLFS 347
Cdd:cd17333 178 ARNPQQSVGAF--SASASRLLRNPSIILGALALFLYVGAETAFSSWV---PSYLVEKKHVSDGLAGYLLSG-----FWVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 348 MFISVVADWMISSKRFSHTATRkLINSIGQYGPGVALIAASYTGcdraltLAILTIGVGLN-GGIYSGFKINHLDLTPRF 426
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLV-LSGSGALLGLLILLLAPTLVV------GLVATALLGLFmAALFPTILSLGISNLPYA 320
|
330 340
....*....|....*....|....*.
gi 24654215 427 AGFLMSITNCSANLAGLLAPIAAGHL 452
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
112-251 |
1.39e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.10 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 112 LSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPIVPCTHAMLAKWI 191
Cdd:cd17323 40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN---IAMLIILRFLQGFFGSSPLAIGAGTIADLF 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654215 192 PPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIV-GTVWSIAFLIF 251
Cdd:cd17323 117 TPEERGKAMGVYSLGPLLGPALGPIIGGFITQS---LGWRWIFWFLAIIsGFCLILIFLFL 174
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
22-256 |
1.49e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 44.58 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 22 QRNLHESLEQQ----PQRCFATRYFVTFMLFLGMAnayVMRTNMSVAIVAMVNHTAiksgeaeeyddecgDRDIPIDDSQ 97
Cdd:TIGR01299 141 RRADEEELAQQyeliIQECGHGRFQWALFFVLGLA---LMADGVEVFVVGFVLPSA--------------EKDLCIPDSG 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 98 DGEFAwSSALQGYILSSFFYGYvitqipfgiLAKKYGSLRFLGYGMLINSVFAFLVPVaARGGGVWGLCavRFIQGLGEG 177
Cdd:TIGR01299 204 KGMLG-LIVYLGMMVGAFFWGG---------LADKLGRKQCLLICLSVNGFFAFFSSF-VQGYGFFLFC--RLLSGFGIG 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 178 PIVPCTHAMLAKWIPPNERSR---------MGAAVYAGAQFGTIIsmPLSGllaeYGFDGGWPSIFY---VFGIV---GT 242
Cdd:TIGR01299 271 GAIPIVFSYFAEFLAQEKRGEhlswlcmfwMIGGIYAAAMAWAII--PHYG----WSFQMGSAYQFHswrVFVIVcafPC 344
|
250
....*....|....
gi 24654215 243 VWSIAFLIFVHEDP 256
Cdd:TIGR01299 345 VFAIGALTFMPESP 358
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
100-262 |
1.58e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.10 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYG---SLRFLGYGMLINSVFAFLVPvaarggGVWGLCAVRFIQGLGE 176
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGrrkSLLIAAVLYVIGALLSALAP------NVWVLIVGRFLLGLGV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 177 GPIVPCTHAMLAKWIPPNERSRMGaavyAGAQFGTIISMpLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDP 256
Cdd:cd17315 102 GLASVLVPLYISEIAPAKIRGALG----TLNQLMITFGI-LLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLP 176
|
....*.
gi 24654215 257 SSHPTI 262
Cdd:cd17315 177 ESRALL 182
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
104-251 |
2.06e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 43.81 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGslRFLGYG-----MLINSVFAFLVPVAARGGGVWGLCAVRFIQGLGEGP 178
Cdd:cd17364 37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFG--RKRVYGveliiMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 179 IVPCTHAMLAKWIPPNERSRMGAAVYA----GAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIV---GTVWSIAFLIF 251
Cdd:cd17364 115 DYPLSATIMSEYANKKRRGALIAAVFAmqgfGILAGAIVTLILSAIFEHPLPAGTYHHADLVWRIVlglGAIPALSVLYF 194
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
104-482 |
2.84e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLR-FLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPC 182
Cdd:cd17490 29 SLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlFIIIGLLFTVLASLIMILF---PSPWGLLIARFLSGIAAATWVSF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 183 ThAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYV---FGIVGTVwsIAFLIfvhEDPSSH 259
Cdd:cd17490 106 T-VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEH---FGMRAPFLLaalAGVLGFI--LSLFI---KEERRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 260 PTIDEREKKYIndslwgTDVVKSPPIPFKAIIKSLPFYaILFAhmghnygyeTLMTELPTYMKQV--LRFSLksnGLLSS 337
Cdd:cd17490 177 KKPVLTELKEL------LSVLKDKKLLFFSLLAILQQM-ITFS---------TTFGFTPLIAKQLgaSSFQL---GLLSI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 338 LpylamwlfSMFISVVADWMISSKRFSHTATRKLInSIGQYGPGVALIAASYTGcdrALTL-----AILTIGVGLNGGIY 412
Cdd:cd17490 238 I--------YLLPNALASLLSGTLFYKKLGERNTI-IIGFLLLGAYCFLIPFAP---NLTLlyllqALNGFGTGILFPLL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654215 413 SGFKINHLDLTPRFA--GFLMSITncsaNLAGLLAPIAAGHLISDPSKpmmgqwQIVFFIAAFVYIICGTFY 482
Cdd:cd17490 306 MSLSIEGVPAEQRSTamGFFQAIY----ALGMFLGPVLVGIISEAFGL------QTGFFVIGVIALLAAILS 367
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
104-256 |
7.44e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 42.09 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVaARGGGVWGLCavRFIQGLGEGPIVPCT 183
Cdd:cd17363 32 SNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSF-VQGYGFFLFC--RLLSGIGIGGSIPIV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 184 HAMLAKWIPPNERSR---------MGAAVYAGAQFGTIIsmPLSGllaeYGFDGGWPSIFY---VFGIVGT---VWSIAF 248
Cdd:cd17363 109 FSYFAEFLAREKRGEhlswlcmfwMIGGLYASAMAWAII--PHYG----WGFSMGTAYQFHswrVFVIVCAlpsVASVVA 182
|
....*...
gi 24654215 249 LIFVHEDP 256
Cdd:cd17363 183 LTFMPESP 190
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
100-260 |
9.44e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.49 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRF-IQGLGEGP 178
Cdd:cd17355 32 EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA---TSLWQLYLLWGlLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 179 IVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEygfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSS 258
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE---AFGWRTALLVLALLALLVLVPVLLLLRRRPAD 185
|
..
gi 24654215 259 HP 260
Cdd:cd17355 186 LA 187
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
104-251 |
1.04e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 183
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA---SGLWVVLLGAILAGLGFGLLLPTL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654215 184 HAMLAKWIPPNERSR-MGA---AVYAGAQFGTIISMPLSGLLaeygfdGGWPSIFYVFGIVGTVWSIAFLIF 251
Cdd:cd17473 308 NSWAMSLVPPELRGRaMGIvtsAFFLGQFLSPLVLGPLVNLT------GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
127-305 |
1.71e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 127 GILAKKYGS---LRFLGYGMLinsvfAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRmgaaV 203
Cdd:cd17370 55 GYLSDRTGKrkpLVILGYGLS-----ALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGK----A 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 204 Y----AGAQFGTIISmPLSGLLAEYGFDGGWPSIFYVFGIVGTVwSIAFLIFVHEDPsshptidEREKKYINDSLWGtdV 279
Cdd:cd17370 126 FglhrALDTLGAVLG-PLLAALLLYLLGGNYRTIFLLAAIPALL-ALLILLFVVKEY-------PRPPKLRKKSKKT--S 194
|
170 180
....*....|....*....|....*.
gi 24654215 280 VKSPPIPFKAIIKSLPFYAILFAHMG 305
Cdd:cd17370 195 LKKLPKAFWLYLLAVALFALGNFSFA 220
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
101-251 |
1.85e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 40.69 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 101 FAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFL--VPVAargggvwgLCAVRFIQGLGEGP 178
Cdd:cd17336 33 FGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLlaLPHF--------LFVGQFLLGIGSSP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 179 IVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSI----------------FYVFGIVGT 242
Cdd:cd17336 105 LYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLgitpddprwigawwlgFLILGILLL 184
|
....*....
gi 24654215 243 VWSIAFLIF 251
Cdd:cd17336 185 IVSIPLFFF 193
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
107-200 |
2.22e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 107 LQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAM 186
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS---PSYELFLVLRFLVGVTSAGIFTVGFVL 102
|
90
....*....|....
gi 24654215 187 LAKWIPPNERSRMG 200
Cdd:cd17317 103 GMEIVGPKYRSFVG 116
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
104-252 |
2.92e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 104 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGY-GMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPC 182
Cdd:cd17490 228 SSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIiGFLLLGAYCFLIPFA---PNLTLLYLLQALNGFGTGILFPL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654215 183 THAMLAKWIPPNERS-RMGA--AVYA-GAQFGTIIsmplSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFV 252
Cdd:cd17490 305 LMSLSIEGVPAEQRStAMGFfqAIYAlGMFLGPVL----VGIISEA---FGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
103-302 |
2.95e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 103 WSsalqGYILSSFFYGYVITQIPFGILAKKYGslRFLgygMLINSVFAFLVPVAARG--GGVWGLCAVRFIQGLGEGPIV 180
Cdd:cd17391 37 WS----GLAFSSTFLVSAIFSPIWGRLADRYG--RKP---MLLRASLGMAIVIGLMAfvTNVWQLLILRLLQGVFSGYVP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 181 PCThAMLAKWIPpneRSRMGAAV---YAGAQFGTIISMPLSGLLAEygfdggWPSIFYVFGIVGTVWSIAFLI---FVHE 254
Cdd:cd17391 108 NAT-ALIASQTP---KEKSGWALgtlSTGVVAGTLIGPLLGGFLAD------LFGIRNVFFITGGLLFLAFLLtlfFVKE 177
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 24654215 255 DpsshptiderekkyindslwGTDVVKSPPIPFKAIIKSLPFYAILFA 302
Cdd:cd17391 178 D--------------------FKPVEKKKMVSTKEVWNSVPNPSLLIS 205
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
126-253 |
3.03e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 126 FGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYA 205
Cdd:cd17489 247 SGKLSDRKGPKTVIIPGLLLLALGLLLLSFA---GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFI 323
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 24654215 206 GAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVwSIAFLIFVH 253
Cdd:cd17489 324 FFDLGIGLGGLLLGLVAEL---FGYRAMFLLAAVVVLL-ALVLYIFLL 367
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
126-321 |
3.89e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 39.91 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 126 FGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYA 205
Cdd:PRK12307 73 FGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS---GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 206 GAQFGTIISMPLSGLLAEYgfdGGWPSIFYvfgiVGTVWSIAFLIFVHEDPSSHPTIderEKKYINDSLWGTDVVKSPPI 285
Cdd:PRK12307 150 GFGIGNIIAAYFMPSFAEA---YGWRAAFF----VGLLPVLLVIYIRARAPESKEWE---EAKLSGKGKHSQSAWSVFSL 219
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 24654215 286 PFKAIIK------SLPFYAILFAHMGHNYGYETLmteLPTYM 321
Cdd:PRK12307 220 SMKGLFNraqfplTLCVFIVLFSIFGANWPIFGL---LPTYL 258
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
100-300 |
6.34e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 100 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEG-- 177
Cdd:cd17478 25 KLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA---PNYWLLLLLVALAGIGSAaf 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 178 -PIVPCTHAMLAKwippnERSRMGAAVY-AGAQFGTIISMPLSGLLAEYGFDGGWPsifyVFGIVGTVWSIAFLIFVheD 255
Cdd:cd17478 102 hPEGARLASQAAG-----GRRGLAMSIFsVGGNLGFALGPLIAAALVALFGGLGLL----ILLIIPGLAVALLLLRL--R 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 24654215 256 PSSHPTIDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAIL 300
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLT 215
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
109-250 |
7.74e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 7.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 109 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArgGGVWGLCAVRFIQGLGEGPIVPCTHAMLA 188
Cdd:cd17365 209 LTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSP--ASLVLLYVLVFLAGACVNGAQVGLYALAA 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654215 189 KWIPPNERSR-MGAAVYAGaQFGTIISMPLSGLLAEYGFdgGWPSIFYVFGIVGTVWSIAFLI 250
Cdd:cd17365 287 RFYPTEVRATgVGWALGVG-RLGAILGPLLGGLLLAAGL--GPESVFLALAIPAALGALAVLL 346
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
112-254 |
9.24e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 38.36 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 112 LSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLinsVFAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWI 191
Cdd:PRK11102 32 LSAYILGFAIGQLFYGPMADSFGRKPVILGGTL---VFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMF 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654215 192 PPNERSRMGAavyagaqFGTIISM--PL-----SGLLAEYgFdgGWPSIFYVFGIVGTVWSIAFLIFVHE 254
Cdd:PRK11102 109 PKEEFSRMMS-------FVTLVMTiaPLlapiiGGWLLVW-F--SWHAIFWVLALAAILAAALVFFFIPE 168
|
|
| |
