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Conserved domains on  [gi|24656357|ref|NP_725981|]
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uncharacterized protein Dmel_CG9945, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-467 2.82e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 2.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 128 ESKIFVTKFNRSGSKLLTACQDGFVRIYDGAKGTYHLLNRIRARDVEWsiidADFSPNGEHFAYSTWSRSLFIMPVNGGE 207
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 208 DdcqwidVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRN-TQILRTHRmpgKDVNSVCFLHDKDpnVIIAG 286
Cdd:cd00200  85 C------VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHT---DWVNSVAFSPDGT--FVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 287 CDDGLLKVYDLRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRqpsnmrnrsrsrqqvdptt 366
Cdd:cd00200 154 SQDGTIKLWDLRT-------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------------- 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 367 wdyrwnrvprefynphkpleGDSSIMTYRGHrvTKTLLRAKFSPmeqtgQRYIYTGCAT-GRIIIYDVLTGKIQEAIEGH 445
Cdd:cd00200 208 --------------------TGKCLGTLRGH--ENGVNSVAFSP-----DGYLLASGSEdGTIRVWDLRTGECVQTLSGH 260

                       330       340
                ....*....|....*....|..
gi 24656357 446 RTVIRDLDWHPDRSEIVSGSWD 467
Cdd:cd00200 261 TNSVTSLAWSPDGKRLASGSAD 282
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-467 2.82e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 2.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 128 ESKIFVTKFNRSGSKLLTACQDGFVRIYDGAKGTYHLLNRIRARDVEWsiidADFSPNGEHFAYSTWSRSLFIMPVNGGE 207
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 208 DdcqwidVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRN-TQILRTHRmpgKDVNSVCFLHDKDpnVIIAG 286
Cdd:cd00200  85 C------VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHT---DWVNSVAFSPDGT--FVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 287 CDDGLLKVYDLRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRqpsnmrnrsrsrqqvdptt 366
Cdd:cd00200 154 SQDGTIKLWDLRT-------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------------- 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 367 wdyrwnrvprefynphkpleGDSSIMTYRGHrvTKTLLRAKFSPmeqtgQRYIYTGCAT-GRIIIYDVLTGKIQEAIEGH 445
Cdd:cd00200 208 --------------------TGKCLGTLRGH--ENGVNSVAFSP-----DGYLLASGSEdGTIRVWDLRTGECVQTLSGH 260

                       330       340
                ....*....|....*....|..
gi 24656357 446 RTVIRDLDWHPDRSEIVSGSWD 467
Cdd:cd00200 261 TNSVTSLAWSPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
136-472 1.65e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 1.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 136 FNRSGSKLLTACQDGFVRIYDGAKGTyhLLNRIRARdvEWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEddCQWIdv 215
Cdd:COG2319 128 FSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRT-- 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 216 ngLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRntQILRTHRMPGKDVNSVCFLHDKDpnVIIAGCDDGLLKVY 295
Cdd:COG2319 200 --LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGR--LLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 296 DLRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDirqpsnmrnrsrsrqqvdpttwdyrwnrvp 375
Cdd:COG2319 274 DLAT-------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD------------------------------ 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 376 refynphkpLEGDSSIMTYRGHrvTKTLLRAKFSPmeqTGQRyIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWH 455
Cdd:COG2319 317 ---------LATGKLLRTLTGH--TGAVRSVAFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330
                ....*....|....*..
gi 24656357 456 PDRSEIVSGSWDTHVHL 472
Cdd:COG2319 382 PDGRTLASGSADGTVRL 398
WD40 pfam00400
WD domain, G-beta repeat;
307-345 1.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24656357   307 SKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWD 345
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 308-345 2.87e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24656357    308 KSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWD 345
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-467 2.82e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 2.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 128 ESKIFVTKFNRSGSKLLTACQDGFVRIYDGAKGTYHLLNRIRARDVEWsiidADFSPNGEHFAYSTWSRSLFIMPVNGGE 207
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 208 DdcqwidVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRN-TQILRTHRmpgKDVNSVCFLHDKDpnVIIAG 286
Cdd:cd00200  85 C------VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHT---DWVNSVAFSPDGT--FVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 287 CDDGLLKVYDLRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRqpsnmrnrsrsrqqvdptt 366
Cdd:cd00200 154 SQDGTIKLWDLRT-------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------------- 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 367 wdyrwnrvprefynphkpleGDSSIMTYRGHrvTKTLLRAKFSPmeqtgQRYIYTGCAT-GRIIIYDVLTGKIQEAIEGH 445
Cdd:cd00200 208 --------------------TGKCLGTLRGH--ENGVNSVAFSP-----DGYLLASGSEdGTIRVWDLRTGECVQTLSGH 260

                       330       340
                ....*....|....*....|..
gi 24656357 446 RTVIRDLDWHPDRSEIVSGSWD 467
Cdd:cd00200 261 TNSVTSLAWSPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
136-472 1.65e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 1.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 136 FNRSGSKLLTACQDGFVRIYDGAKGTyhLLNRIRARdvEWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEddCQWIdv 215
Cdd:COG2319 128 FSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRT-- 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 216 ngLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRntQILRTHRMPGKDVNSVCFLHDKDpnVIIAGCDDGLLKVY 295
Cdd:COG2319 200 --LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGR--LLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 296 DLRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDirqpsnmrnrsrsrqqvdpttwdyrwnrvp 375
Cdd:COG2319 274 DLAT-------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD------------------------------ 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 376 refynphkpLEGDSSIMTYRGHrvTKTLLRAKFSPmeqTGQRyIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWH 455
Cdd:COG2319 317 ---------LATGKLLRTLTGH--TGAVRSVAFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330
                ....*....|....*..
gi 24656357 456 PDRSEIVSGSWDTHVHL 472
Cdd:COG2319 382 PDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
121-472 1.86e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 1.86e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 121 ATRLMSLESKIFVTKFNRSGSKLLTACQDGFVRIYDGAKGTYHLLNRIRARDVeWSIidaDFSPNGEHFAYSTWSRSLFI 200
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV-RSV---AFSPDGKTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 201 MPVNGGEDdcqwidVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRT-RNTQILRTHrmpGKDVNSVCFlhDKD 279
Cdd:COG2319 147 WDLATGKL------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgKLLRTLTGH---TGAVRSVAF--SPD 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 280 PNVIIAGCDDGLLKVYDLRTTfrsrdlsKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDirqpsnmrnrsrsr 359
Cdd:COG2319 216 GKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-------------- 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 360 qqvdpttwdyrwnrvprefynphkpLEGDSSIMTYRGHrvTKTLLRAKFSPmeqtGQRYIYTGCATGRIIIYDVLTGKIQ 439
Cdd:COG2319 275 -------------------------LATGELLRTLTGH--SGGVNSVAFSP----DGKLLASGSDDGTVRLWDLATGKLL 323

                       330       340       350
                ....*....|....*....|....*....|...
gi 24656357 440 EAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVHL 472
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
136-347 2.53e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.53e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 136 FNRSGSKLLTACQDGFVRIYDGAKGTyhLLNRIRARDveWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEddCQWIdv 215
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHS--GSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--LLRT-- 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 216 ngLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRntQILRTHRMPGKDVNSVCFLHDKdpNVIIAGCDDGLLKVY 295
Cdd:COG2319 284 --LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLW 357

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 24656357 296 DLRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIR 347
Cdd:COG2319 358 DLAT-------GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 218-472 2.31e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 2.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 218 LPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQI-LRTHRMPGKDVNSVCFLhdkdpNVIIAGCDDGLLKVYD 296
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADG-----TYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 297 LRTtfrsrdlSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRQPSNmrnrsrsrqqvdpttwdyrwnrvpr 376
Cdd:cd00200  80 LET-------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC------------------------- 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 377 efynphkplegdssIMTYRGHrvTKTLLRAKFSPmeqtGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHP 456
Cdd:cd00200 128 --------------LTTLRGH--TDWVNSVAFSP----DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                       250
                ....*....|....*.
gi 24656357 457 DRSEIVSGSWDTHVHL 472
Cdd:cd00200 188 DGEKLLSSSSDGTIKL 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-470 6.20e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 6.20e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 176 SIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQwidvngLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRN 255
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT------LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 256 -TQILRTHRmpgKDVNSVCFLHDKDpnvIIAGC-DDGLLKVYDLRTTfrsrdlsKSVASFIGHYDGITYIDSRNDGYHVL 333
Cdd:cd00200  85 cVRTLTGHT---SYVSSVAFSPDGR---ILSSSsRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 334 SNSKDQSIKIWDIRQPSnmrnrsrsrqqvdpttwdyrwnrvprefynphkplegdsSIMTYRGHrvTKTLLRAKFSPmeq 413
Cdd:cd00200 152 SSSQDGTIKLWDLRTGK---------------------------------------CVATLTGH--TGEVNSVAFSP--- 187

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24656357 414 TGQRYIyTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHV 470
Cdd:cd00200 188 DGEKLL-SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
164-472 1.88e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 1.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 164 LLNRIRARDVEWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDdcqwidVNGLPSHRLAIFSLRYSPTGDKIIGGSNN 243
Cdd:COG2319  26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL------LATLLGHTAAVLSVAFSPDGRLLASASAD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 244 STVIVTDIRTrnTQILRTHRMPGKDVNSVCFLHDKdpNVIIAGCDDGLLKVYDLRTTfrsrdlsKSVASFIGHYDGITYI 323
Cdd:COG2319 100 GTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSPDG--KTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSV 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 324 DSRNDGYHVLSNSKDQSIKIWDIRQPSNMRnrsrsrqqvdpttwdyrwnrvprefynphkplegdssimTYRGHrvTKTL 403
Cdd:COG2319 169 AFSPDGKLLASGSDDGTVRLWDLATGKLLR---------------------------------------TLTGH--TGAV 207

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24656357 404 LRAKFSPmeqtGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVHL 472
Cdd:COG2319 208 RSVAFSP----DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 255-472 1.55e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 255 NTQILRTHRmpgKDVNSVCFlhDKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSksvasfiGHYDGITYIDSRNDGYHVLS 334
Cdd:cd00200   1 LRRTLKGHT---GGVTCVAF--SPDGKLLATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASADGTYLAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 335 NSKDQSIKIWDirqpsnmrnrsrsrqqvdpttwdyrwnrvprefynphkpLEGDSSIMTYRGHrvTKTLLRAKFSPMeqt 414
Cdd:cd00200  69 GSSDKTIRLWD---------------------------------------LETGECVRTLTGH--TSYVSSVAFSPD--- 104

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24656357 415 gQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVHL 472
Cdd:cd00200 105 -GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-345 4.52e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 4.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 135 KFNRSGSKLLTACQDGFVRIYDGAKGTYhllnRIRARDVEWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEddCQWId 214
Cdd:cd00200 100 AFSPDGRILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVAT- 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 215 vngLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRT-RNTQILRTHRMPgkdVNSVCFLHDKDpnvIIAGCD-DGLL 292
Cdd:cd00200 173 ---LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTgKCLGTLRGHENG---VNSVAFSPDGY---LLASGSeDGTI 243

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 24656357 293 KVYDLRTTfrsrdlsKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWD 345
Cdd:cd00200 244 RVWDLRTG-------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
136-299 4.72e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 4.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 136 FNRSGSKLLTACQDGFVRIYDGAKGTyhLLNRIRARDveWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDdcqwidV 215
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATGE--LLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL------L 323

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656357 216 NGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRntQILRTHRMPGKDVNSVCFLHDKdpNVIIAGCDDGLLKVY 295
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTSVAFSPDG--RTLASGSADGTVRLW 399


                ....
gi 24656357 296 DLRT 299
Cdd:COG2319 400 DLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
307-345 1.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24656357   307 SKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWD 345
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 308-345 2.87e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24656357    308 KSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWD 345
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 435-472 5.07e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24656357    435 TGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVHL 472
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
436-472 5.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 24656357   436 GKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVHL 472
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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