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Conserved domains on  [gi|24657306|ref|NP_726114|]
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lamin B receptor, isoform C [Drosophila melanogaster]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 304-741 1.80e-27

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 116.00  E-value: 1.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   304 APREFGGWLGAFLFLLLLPTAVYYLtWSCTARNA---------------CQFKHLNLGILLDVnYLTRQVFqprvvGAFA 368
Cdd:pfam01222   3 IEYEFGGEIGALGIKIGLPVFMLYL-NGCSGFFMlmfflpksfdiavlmNFIKDPSLMVFPGL-EWERYLW-----TVFL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   369 AYQVVVFLLVALLPGRRVHLT------RETYKFNCLAVSLTLLIASGVAEYLKYPVVTFVLRHYLRFCIFGLVGAFVAAA 442
Cdd:pfam01222  76 LWYFFQAVFYLTLPGKVVEGLplsngrKLPYKINAFWSFLLTLAAIGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   443 WSYwlvdTAKYNVLrQTLTNDYGR-TGSFVVDFALGRQLNPKWlGRVDWKQF-QYRLSLVTTLIYATCYIyqtlvwpqkp 520
Cdd:pfam01222 156 YLY----VRSLKAP-EEDKDAPGGnSGNLIYDFFIGRELNPRI-GSLDIKMFfELRPGLLGWVFINLAAL---------- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   521 qlgeqegyLYQAKYYwNNVNydPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYF 599
Cdd:pfam01222 220 --------LKQYETY-GYVT--PSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFgDLVWVPFTYSLQTRYL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   600 YEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIVA 679
Cdd:pfam01222 289 SVHPSELGWSTYAVAIYALLLCGYYIFRSANSQKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQ 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24657306   680 LLALAApmalrPAW----PPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRSYILPRVY 741
Cdd:pfam01222 369 SLSWSL-----PTGfnsvLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
304-741 1.80e-27

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 116.00  E-value: 1.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   304 APREFGGWLGAFLFLLLLPTAVYYLtWSCTARNA---------------CQFKHLNLGILLDVnYLTRQVFqprvvGAFA 368
Cdd:pfam01222   3 IEYEFGGEIGALGIKIGLPVFMLYL-NGCSGFFMlmfflpksfdiavlmNFIKDPSLMVFPGL-EWERYLW-----TVFL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   369 AYQVVVFLLVALLPGRRVHLT------RETYKFNCLAVSLTLLIASGVAEYLKYPVVTFVLRHYLRFCIFGLVGAFVAAA 442
Cdd:pfam01222  76 LWYFFQAVFYLTLPGKVVEGLplsngrKLPYKINAFWSFLLTLAAIGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   443 WSYwlvdTAKYNVLrQTLTNDYGR-TGSFVVDFALGRQLNPKWlGRVDWKQF-QYRLSLVTTLIYATCYIyqtlvwpqkp 520
Cdd:pfam01222 156 YLY----VRSLKAP-EEDKDAPGGnSGNLIYDFFIGRELNPRI-GSLDIKMFfELRPGLLGWVFINLAAL---------- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   521 qlgeqegyLYQAKYYwNNVNydPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYF 599
Cdd:pfam01222 220 --------LKQYETY-GYVT--PSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFgDLVWVPFTYSLQTRYL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   600 YEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIVA 679
Cdd:pfam01222 289 SVHPSELGWSTYAVAIYALLLCGYYIFRSANSQKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQ 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24657306   680 LLALAApmalrPAW----PPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRSYILPRVY 741
Cdd:pfam01222 369 SLSWSL-----PTGfnsvLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
304-741 1.80e-27

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 116.00  E-value: 1.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   304 APREFGGWLGAFLFLLLLPTAVYYLtWSCTARNA---------------CQFKHLNLGILLDVnYLTRQVFqprvvGAFA 368
Cdd:pfam01222   3 IEYEFGGEIGALGIKIGLPVFMLYL-NGCSGFFMlmfflpksfdiavlmNFIKDPSLMVFPGL-EWERYLW-----TVFL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   369 AYQVVVFLLVALLPGRRVHLT------RETYKFNCLAVSLTLLIASGVAEYLKYPVVTFVLRHYLRFCIFGLVGAFVAAA 442
Cdd:pfam01222  76 LWYFFQAVFYLTLPGKVVEGLplsngrKLPYKINAFWSFLLTLAAIGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   443 WSYwlvdTAKYNVLrQTLTNDYGR-TGSFVVDFALGRQLNPKWlGRVDWKQF-QYRLSLVTTLIYATCYIyqtlvwpqkp 520
Cdd:pfam01222 156 YLY----VRSLKAP-EEDKDAPGGnSGNLIYDFFIGRELNPRI-GSLDIKMFfELRPGLLGWVFINLAAL---------- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   521 qlgeqegyLYQAKYYwNNVNydPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYF 599
Cdd:pfam01222 220 --------LKQYETY-GYVT--PSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFgDLVWVPFTYSLQTRYL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657306   600 YEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIVA 679
Cdd:pfam01222 289 SVHPSELGWSTYAVAIYALLLCGYYIFRSANSQKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQ 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24657306   680 LLALAApmalrPAW----PPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRSYILPRVY 741
Cdd:pfam01222 369 SLSWSL-----PTGfnsvLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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