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Conserved domains on  [gi|24657968|ref|NP_726190|]
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Gp150, isoform A [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-733 6.74e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 6.74e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  316 NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 395
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  396 LSQNslkklpeKAFEKVTLLEELDLSYNSLTELPRDIFNGTtlsilhlkyntfngdlhfgtkDLQQLDLSFNSIVQVhHS 475
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLT---------------------NLKELDLSNNQLTDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  476 MFDKMPGLTNLNLKGNGIKKIqPDSFLTLKNLRHIDLSINDLDQISGMLfFKNSELDVIRLNDNpRLSQLPtdgflsysg 555
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN-QLTDLP--------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  556 eftvyyldisncaigplghKAFSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLS 635
Cdd:COG4886  222 -------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  636 LAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITN 715
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        410
                 ....*....|....*...
gi 24657968  716 NPLKCTPDFQEFISYVTL 733
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-733 6.74e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 6.74e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  316 NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 395
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  396 LSQNslkklpeKAFEKVTLLEELDLSYNSLTELPRDIFNGTtlsilhlkyntfngdlhfgtkDLQQLDLSFNSIVQVhHS 475
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLT---------------------NLKELDLSNNQLTDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  476 MFDKMPGLTNLNLKGNGIKKIqPDSFLTLKNLRHIDLSINDLDQISGMLfFKNSELDVIRLNDNpRLSQLPtdgflsysg 555
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN-QLTDLP--------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  556 eftvyyldisncaigplghKAFSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLS 635
Cdd:COG4886  222 -------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  636 LAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITN 715
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        410
                 ....*....|....*...
gi 24657968  716 NPLKCTPDFQEFISYVTL 733
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 318-642 1.61e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.45  E-value: 1.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   318 LYAVNLTDVGLAIINPDTFVGN--------KKLRMLTISGNDLSvmSSIHYLL-KSSSIEELDFSRNNLMELNPKAFSHL 388
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVGQiprelgqmKSLKWIYLGYNNLS--GEIPYEIgGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   389 SNVVYINLSQNSLK-KLPEKAFEkVTLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDLHFGTKD---LQQLD 463
Cdd:PLN00113  260 KNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSlprLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   464 LSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLD-QISGMLFFKNSeLDVIRLNDNPRL 542
Cdd:PLN00113  339 LWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRS-LRRVRLQDNSFS 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   543 SQLPTdgflsysgEFT----VYYLDISNCAI-GPLGHKAFStMPHLTTLKLAWNNI-NHLPReiFTGLHKLIDLDLSNNL 616
Cdd:PLN00113  418 GELPS--------EFTklplVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQ 486

                         330       340
                  ....*....|....*....|....*.
gi 24657968   617 ITRMDDLIFMDNGELTKLSLAGNPIS 642
Cdd:PLN00113  487 FSGAVPRKLGSLSELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
581-641 4.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 4.42e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657968    581 PHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPI 641
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 577-718 5.71e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 5.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  577 FSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLSLAGNPISRLS----------- 645
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVN--LKKLYLGGNRISVVEglenltnleel 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  646 ----VRL-------FLP------LHQLRCLDVNDCELTTLlsdRDLgagyKIFDSLRSFNASGNLIKKIS--SEDVKSFK 706
Cdd:cd21340   96 hienQRLppgekltFDPrslaalSNSLRVLNISGNNIDSL---EPL----APLRNLEQLDASNNQISDLEelLDLLSSWP 168

                        170
                 ....*....|..
gi 24657968  707 NLRSLDITNNPL 718
Cdd:cd21340  169 SLRELDLTGNPV 180
LRR smart00370
Leucine-rich repeats, outliers;
415-435 4.72e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.72e-03
                            10        20
                    ....*....|....*....|.
gi 24657968     415 LEELDLSYNSLTELPRDIFNG 435
Cdd:smart00370    4 LRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-733 6.74e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 6.74e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  316 NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 395
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  396 LSQNslkklpeKAFEKVTLLEELDLSYNSLTELPRDIFNGTtlsilhlkyntfngdlhfgtkDLQQLDLSFNSIVQVhHS 475
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLT---------------------NLKELDLSNNQLTDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  476 MFDKMPGLTNLNLKGNGIKKIqPDSFLTLKNLRHIDLSINDLDQISGMLfFKNSELDVIRLNDNpRLSQLPtdgflsysg 555
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN-QLTDLP--------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  556 eftvyyldisncaigplghKAFSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLS 635
Cdd:COG4886  222 -------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  636 LAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITN 715
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        410
                 ....*....|....*...
gi 24657968  716 NPLKCTPDFQEFISYVTL 733
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 318-642 1.61e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.45  E-value: 1.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   318 LYAVNLTDVGLAIINPDTFVGN--------KKLRMLTISGNDLSvmSSIHYLL-KSSSIEELDFSRNNLMELNPKAFSHL 388
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVGQiprelgqmKSLKWIYLGYNNLS--GEIPYEIgGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   389 SNVVYINLSQNSLK-KLPEKAFEkVTLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDLHFGTKD---LQQLD 463
Cdd:PLN00113  260 KNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSlprLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   464 LSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLD-QISGMLFFKNSeLDVIRLNDNPRL 542
Cdd:PLN00113  339 LWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRS-LRRVRLQDNSFS 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   543 SQLPTdgflsysgEFT----VYYLDISNCAI-GPLGHKAFStMPHLTTLKLAWNNI-NHLPReiFTGLHKLIDLDLSNNL 616
Cdd:PLN00113  418 GELPS--------EFTklplVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQ 486

                         330       340
                  ....*....|....*....|....*.
gi 24657968   617 ITRMDDLIFMDNGELTKLSLAGNPIS 642
Cdd:PLN00113  487 FSGAVPRKLGSLSELMQLKLSENKLS 512
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
413-719 3.60e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 3.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  413 TLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNG 492
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  493 IKKIQPDSFLTLKNLRHIDLSINDldqisgmLFFKNSELDVIRLNDNpRLSQLPTD-GFLSysgefTVYYLDISNCAIGP 571
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN-QLTDLPEElANLT-----NLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  572 LGhKAFSTMPHLTTLKLAWNNINHLPREIFtGLHKLIDLDLSNNLITRMDDLIfMDNGELTKLSLAGNPISRLSVRLFlP 651
Cdd:COG4886  151 LP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLA-N 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24657968  652 LHQLRCLDVNDCELTTLlsdRDLGAgykiFDSLRSFNASGNLIKKISSEdvKSFKNLRSLDITNNPLK 719
Cdd:COG4886  227 LTNLETLDLSNNQLTDL---PELGN----LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 361-538 8.88e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.41  E-value: 8.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   361 LLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLT-ELPRDIFNGTTLS 439
Cdd:PLN00113  376 LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQ 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   440 ILHLKYNTFNGDL--HFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINdl 517
Cdd:PLN00113  456 MLSLARNKFFGGLpdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN-- 533

                         170       180
                  ....*....|....*....|.
gi 24657968   518 dQISGMLFFKNSELDVIRLND 538
Cdd:PLN00113  534 -QLSGQIPASFSEMPVLSQLD 553
LRR_8 pfam13855
Leucine rich repeat;
581-641 4.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 4.42e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657968    581 PHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPI 641
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
365-425 5.49e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 5.49e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657968    365 SSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSL 425
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 577-718 5.71e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 5.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  577 FSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLSLAGNPISRLS----------- 645
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVN--LKKLYLGGNRISVVEglenltnleel 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  646 ----VRL-------FLP------LHQLRCLDVNDCELTTLlsdRDLgagyKIFDSLRSFNASGNLIKKIS--SEDVKSFK 706
Cdd:cd21340   96 hienQRLppgekltFDPrslaalSNSLRVLNISGNNIDSL---EPL----APLRNLEQLDASNNQISDLEelLDLLSSWP 168

                        170
                 ....*....|..
gi 24657968  707 NLRSLDITNNPL 718
Cdd:cd21340  169 SLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
459-517 2.52e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.52e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24657968    459 LQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDL 517
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
558-617 8.74e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 8.74e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968    558 TVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLI 617
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 333-452 2.08e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   333 PDTFvGNKKLRMLTISGNDLSVMSSiHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKV 412
Cdd:PLN00113  469 PDSF-GSKRLENLDLSRNQFSGAVP-RKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEM 546

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24657968   413 TLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDL 452
Cdd:PLN00113  547 PVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHGSL 587
LRR_8 pfam13855
Leucine rich repeat;
481-540 3.55e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.55e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968    481 PGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNP 540
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
333-493 4.41e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 4.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   333 PDTFVGNkkLRMLTISGNDLSVMSSIhyllKSSSIEELDFSRNNLMELNPKAFSHLSNVVyinLSQNSLKKLPEKAFEKv 412
Cdd:PRK15370  215 PENLQGN--IKTLYANSNQLTSIPAT----LPDTIQEMELSINRITELPERLPSALQSLD---LFHNKISCLPENLPEE- 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   413 tlLEELDLSYNSLTELPRDIFNGttlsILHLkyNTFNGDLHFGTK----DLQQLDLSFNSIVQVHHSMfdkMPGLTNLNL 488
Cdd:PRK15370  285 --LRYLSVYDNSIRTLPAHLPSG----ITHL--NVQSNSLTALPEtlppGLKTLEAGENALTSLPASL---PPELQVLDV 353


                  ....*
gi 24657968   489 KGNGI 493
Cdd:PRK15370  354 SKNQI 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 364-639 4.65e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   364 SSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLK-KLPEKAFE----------------------KVTLLEELDL 420
Cdd:PLN00113   68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTtssslrylnlsnnnftgsiprgSIPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   421 SYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLD---LSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKI 496
Cdd:PLN00113  148 SNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   497 QPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLP--------------TDGFLsySGEFTVYYL 562
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPpsifslqklisldlSDNSL--SGEIPELVI 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   563 DISNCAIGPLGHKAF--------STMPHLTTLKLaWNniNHLPREIFTGLHK---LIDLDLS-NNLITRMDDLIfMDNGE 630
Cdd:PLN00113  306 QLQNLEILHLFSNNFtgkipvalTSLPRLQVLQL-WS--NKFSGEIPKNLGKhnnLTVLDLStNNLTGEIPEGL-CSSGN 381


                  ....*....
gi 24657968   631 LTKLSLAGN 639
Cdd:PLN00113  382 LFKLILFSN 390
LRR_8 pfam13855
Leucine rich repeat;
415-493 1.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.19e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24657968    415 LEELDLSYNSLTELPRDIFngttlsilhlkyntfngdlhFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGI 493
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAF--------------------KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 477-645 4.08e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  477 FDKMPGLTNLNLKGNGIKKIQPdsFLTLKNLRHIDLSINDLDQISGMLFFKN-SELDVirlnDNPRLSqlPTDGFLSysG 555
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEGLENLTNlEELHI----ENQRLP--PGEKLTF--D 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  556 EFTVYYldISNCaigplghkafstmphLTTLKLAWNNINHLprEIFTGLHKLIDLDLSNNLITRMDDL--IFMDNGELTK 633
Cdd:cd21340  112 PRSLAA--LSNS---------------LRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELldLLSSWPSLRE 172

                        170
                 ....*....|..
gi 24657968  634 LSLAGNPISRLS 645
Cdd:cd21340  173 LDLTGNPVCKKP 184
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 364-450 4.19e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.07  E-value: 4.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968    364 SSSIEELDFSrNNLMELNPKAFSHlSNVVYINLSqNSLKKLPEKAFEKVTLLEELDLSyNSLTELPRDIFNGTTL----- 438
Cdd:pfam13306   33 CTSLKSITLP-SSLTSIGSYAFYN-CSLTSITIP-SSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAFSNCSLksiti 108

                           90
                   ....*....|....
gi 24657968    439 --SILHLKYNTFNG 450
Cdd:pfam13306  109 psSVTTIGSYAFSN 122
LRR_8 pfam13855
Leucine rich repeat;
610-665 6.50e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.50e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24657968    610 LDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCEL 665
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
389-446 7.31e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24657968    389 SNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNG-TTLSILHLKYN 446
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 561-720 9.25e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  561 YLDISNCAIGPLG---HKAFSTMPHLTTLKLAWNNINHLP-REIFTGL----HKLIDLDLSNNLITR--MDDL--IFMDN 628
Cdd:cd00116   85 ELDLSDNALGPDGcgvLESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRLEGasCEALakALRAN 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  629 GELTKLSLAGNPIS----RLSVRLFLPLHQLRCLDVNDCELTTlLSDRDLGAGYKIFDSLRSFNASGNLIK-----KISS 699
Cdd:cd00116  165 RDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTD-EGASALAETLASLKSLEVLNLGDNNLTdagaaALAS 243

                        170       180
                 ....*....|....*....|.
gi 24657968  700 EDVKSFKNLRSLDITNNPLKC 720
Cdd:cd00116  244 ALLSPNISLLTLSLSCNDITD 264
LRR_8 pfam13855
Leucine rich repeat;
293-352 9.63e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 9.63e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968    293 NVASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDL 352
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 367-452 1.36e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968   367 IEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKY 445
Cdd:PLN03150  420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNG 499


                  ....*..
gi 24657968   446 NTFNGDL 452
Cdd:PLN03150  500 NSLSGRV 506
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 342-419 1.38e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  342 LRMLTISGNDLSVMSSIHYLlksSSIEELDFSRNNLMELNP--KAFSHLSNVVYINLSQNSLKKLPeKAFEKVTL----L 415
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPL---RNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP-KYRDKIILasksL 197


                 ....
gi 24657968  416 EELD 419
Cdd:cd21340  198 EVLD 201
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 338-493 1.48e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  338 GNKKLRMLTISGNDLS---VMSSIHYLLKSSSIEELDFSRNNLMELNPKAFShlsnvvyinlsqnslkklpeKAFEKVTL 414
Cdd:COG5238  234 GNKSLTTLDLSNNQIGdegVIALAEALKNNTTVETLYLSGNQIGAEGAIALA--------------------KALQGNTT 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  415 LEELDLSYNSLTE-----LPRDIFNGTTLSILHLKYNTFNGD--------LHFGTKdLQQLDLSFNSI----VQVHHSMF 477
Cdd:COG5238  294 LTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGAQgaialakaLQENTT-LHSLDLSDNQIgdegAIALAKYL 372

                        170
                 ....*....|....*.
gi 24657968  478 DKMPGLTNLNLKGNGI 493
Cdd:COG5238  373 EGNTTLRELNLGKNNI 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-488 1.74e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  290 GLKNVASIKIANCTLEYLHaEAFHGLNELYAVNLTDVGLAIInPDTFVGNKKLRMLTISGNDLSVMSSIHYLlksSSIEE 369
Cdd:COG4886  180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNL---TNLEE 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  370 LDFSRNNLMELNPkaFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFN 449
Cdd:COG4886  255 LDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 24657968  450 GDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNL 488
Cdd:COG4886  333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
LRR_8 pfam13855
Leucine rich repeat;
317-401 2.29e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968    317 ELYAVNLTDVGLAIINPDTFVGNKKLRMltisgndlsvmssihyllksssieeLDFSRNNLMELNPKAFSHLSNVVYINL 396
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKV-------------------------LDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                   ....*
gi 24657968    397 SQNSL 401
Cdd:pfam13855   57 SGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 409-665 3.46e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  409 FEKVTLLEELDLSYNSLTE-----LPRDIFNGTTLSILHLKYNtFNGDLHFGTKD----------LQQLDLSFNSI---- 469
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLN-ETGRIPRGLQSllqgltkgcgLQELDLSDNALgpdg 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  470 VQVHHSmFDKMPGLTNLNLKGNGIK----KIQPDSFLTLK-NLRHIDLSINDL-----DQISGmLFFKNSELDVIRLNDN 539
Cdd:cd00116   98 CGVLES-LLRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLegascEALAK-ALRANRDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  540 PRLSQLPT---DGFLSYSGeftVYYLDISNCAIGPLGHKA----FSTMPHLTTLKLAWNNIN-----HLPREIFTGLHKL 607
Cdd:cd00116  176 GIGDAGIRalaEGLKANCN---LEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTdagaaALASALLSPNISL 252

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24657968  608 IDLDLSNNLITRMDDLIFM----DNGELTKLSLAGNPISRLSVRL-FLPLHQLRC----LDVNDCEL 665
Cdd:cd00116  253 LTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEEGAQLlAESLLEPGNelesLWVKDDSF 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 349-594 8.78e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 8.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  349 GNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNP---KAFSHLSNVVYINLSQNSLKKLPEKAFEKVTL-----LEELDL 420
Cdd:cd00116   65 RIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKdlppaLEKLVL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  421 SYNSLT-ELPRDIfnGTTLSilhlkyntFNGDLHfgtkdlqQLDLSFNSIvqvhhsmfdkmpgltnlnlKGNGIKKIQPD 499
Cdd:cd00116  145 GRNRLEgASCEAL--AKALR--------ANRDLK-------ELNLANNGI-------------------GDAGIRALAEG 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  500 sFLTLKNLRHIDLSINDL----DQISGMLFFKNSELDVIRLNDNPrLSQLPTDGFLS--YSGEFTVYYLDISNCAIGPLG 573
Cdd:cd00116  189 -LKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNN-LTDAGAAALASalLSPNISLLTLSLSCNDITDDG 266

                        250       260
                 ....*....|....*....|....*
gi 24657968  574 HKAFST----MPHLTTLKLAWNNIN 594
Cdd:cd00116  267 AKDLAEvlaeKESLLELDLRGNKFG 291
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 340-497 3.17e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 3.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  340 KKLRMLTISGNDLSVMSSIHYLlksSSIEELDFSRNNLMELNPkaFSHLSNVVYINLSQNSLKKLpeKAFEKVTLLEELD 419
Cdd:cd21340   24 KNLKVLYLYDNKITKIENLEFL---TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  420 LSY------NSLTELPRDIFN-GTTLSILHLKYN--TFNGDLHFGTKdLQQLDLSFNSIVQVHH--SMFDKMPGLTNLNL 488
Cdd:cd21340   97 IENqrlppgEKLTFDPRSLAAlSNSLRVLNISGNniDSLEPLAPLRN-LEQLDASNNQISDLEEllDLLSSWPSLRELDL 175


                 ....*....
gi 24657968  489 KGNGIKKIQ 497
Cdd:cd21340  176 TGNPVCKKP 184
LRR smart00370
Leucine-rich repeats, outliers;
415-435 4.72e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.72e-03
                            10        20
                    ....*....|....*....|.
gi 24657968     415 LEELDLSYNSLTELPRDIFNG 435
Cdd:smart00370    4 LRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
415-435 4.72e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.72e-03
                            10        20
                    ....*....|....*....|.
gi 24657968     415 LEELDLSYNSLTELPRDIFNG 435
Cdd:smart00369    4 LRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 365-540 5.47e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  365 SSIEELDFSRNnLMELnpkafsHLSNvvyinlsqNSLKKLPEkaFEKVTLLEELDLSYNSLTELprdifNG----TTLSI 440
Cdd:cd21340   37 TKIENLEFLTN-LTHL------YLQN--------NQIEKIEN--LENLVNLKKLYLGGNRISVV-----EGlenlTNLEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657968  441 LHLKYntfngdlhfgtkdlQQLD----LSFNSivqvhHSMFDKMPGLTNLNLKGNGIKKIQPdsFLTLKNLRHIDLS--- 513
Cdd:cd21340   95 LHIEN--------------QRLPpgekLTFDP-----RSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASnnq 153

                        170       180
                 ....*....|....*....|....*..
gi 24657968  514 INDLDQISGMLfFKNSELDVIRLNDNP 540
Cdd:cd21340  154 ISDLEELLDLL-SSWPSLRELDLTGNP 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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