BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKST-PCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEV 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24639128 110 LRVSG 114
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKST-PCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEV 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24639128 110 LRVSG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128     33 DVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC--KHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 24639128    111 RVSGLTQQ 118
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKST-PCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEV 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24639128 110 LRVSG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128     33 DVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC--KHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 24639128    111 RVSGLTQQ 118
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  16 SSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEV 93
Cdd:cd18247   4 SSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHdmVESKQDEITMQGIEPSALEALINFAYSGRI 83

                        90
                ....*....|....*..
gi 24639128  94 NVHQKSLQSFLKTAEVL 110
Cdd:cd18247  84 AIDTSNVQSLLVGASFL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  15 QSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGE 92
Cdd:cd18237   5 LADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSnmTESKSSEVELKDAEPDIIELLVEFAYTAR 84

                        90
                ....*....|....*
gi 24639128  93 VNVHQKSLQSFLKTA 107
Cdd:cd18237  85 ISVNSNNVQSLLDAA 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  21 AFENLRD---DEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNV 95
Cdd:cd18238   2 SFKVLHQfyeNGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSemAESKQDSITIKDIDEEAVELLVDFAYTGKLTL 81

                        90
                ....*....|....*..
gi 24639128  96 HQKSLQSFLKTAEVLRV 112
Cdd:cd18238  82 TVDNVQSLLYAASLLQV 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  21 AFEN---LRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNV 95
Cdd:cd18235   8 AFDVmneLRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGdlSESRANRVTLQDVDGKALLLLIDYVYTAEIQV 87

                        90
                ....*....|....*
gi 24639128  96 HQKSLQSFLKTAEVL 110
Cdd:cd18235  88 TEENVQVLLPAANLL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  12 NNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIY 89
Cdd:cd18242   2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSemSEKGKSEVELQGLTASTMEILLDFVY 81

                        90       100
                ....*....|....*....|....*...
gi 24639128  90 HGEVNVHQKSLQSFLKTAEVLRVSGLTQ 117
Cdd:cd18242  82 TETVHVTVENVQELLPAACLLQLKGVKQ 109

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  22 FENLRDDEAFVDVTL-ACEGRSIKAHRVVLSACSPYFRELLkstpCKHPVILL-QDVNFMDLHALVEFIYHGEVNVHQKS 99
Cdd:cd18299   3 LRNLLHSPSCADVVFiLQGGVRIFAHRIVLAAASSVFADLF----LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDD 78

                        90
                ....*....|....*...
gi 24639128 100 LQSFLKTAEVLRVSGLTQ 117
Cdd:cd18299  79 LKELKDAAELLELFDLVM 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  17 SITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVN 94
Cdd:cd18253   4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNdhRESREMLVEINGILAEAMDCFLQYVYTGKVK 83

                        90       100
                ....*....|....*....|.
gi 24639128  95 VHQKSLQSFLKTAEVLRVSGL 115
Cdd:cd18253  84 ITTENVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  14 YQSSI-TSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYH 90
Cdd:cd18269   9 YQQTLlQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSdlEESKKKEVVLEDVDPDVMGMILKYLYT 88

                        90       100
                ....*....|....*....|..
gi 24639128  91 GEVNVHQKSLQSFLKTAEVLRV 112
Cdd:cd18269  89 SEIDLNDQNVQDIFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  25 LRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELL--KSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQS 102
Cdd:cd18338  15 LRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFtgEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQV 94

                        90       100
                ....*....|....*....|....*
gi 24639128 103 FLKTAEVLRVSGLTQQQAEDTHSHL 127
Cdd:cd18338  95 LLPAAGLLQLQDVKKTCCEFLESQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  21 AFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHP----VILLQDVNFMDLHALVEFIYHGEVNVH 96
Cdd:cd18245   4 ALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQIKLS 83

                        90
                ....*....|....*....
gi 24639128  97 QKSLQSFLKTAEVLRVSGL 115
Cdd:cd18245  84 EDNIQDIVQAADLLLMTDL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  25 LRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQS 102
Cdd:cd18255  12 LRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQD 91

                        90       100
                ....*....|....*....|....*
gi 24639128 103 FLKTAEVLRVSGLTQQQAEDTHSHL 127
Cdd:cd18255  92 VLGAAVHLQMLPVVELCEEFLKSAM 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  14 YQSSI-TSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYH 90
Cdd:cd18341   9 YQSTLlQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSeeSEEKKKEVVLDNVDPNIMDMILKYLYS 88

                        90
                ....*....|....*..
gi 24639128  91 GEVNVHQKSLQSFLKTA 107
Cdd:cd18341  89 AEIDLNDGNVQDIFALA 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  15 QSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKST--PCKHPVILLQDVNFMDLHALVEFIYHGE 92
Cdd:cd18340  11 QTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDleESKKREIVLEDVDPDVMGKILHYIYTSE 90

                        90       100
                ....*....|....*....|
gi 24639128  93 VNVHQKSLQSFLKTAEVLRV 112
Cdd:cd18340  91 IEITEQNVQDIFAAANMFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  22 FENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELL-----KSTPCKhpvILLQDVNFMDLHALVEFIYHGEVNVH 96
Cdd:cd18287  13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmrESQQSE---IELKDTNAEAFKALLKYIYTGRLTLT 89

                        90       100
                ....*....|....*....|..
gi 24639128  97 QkslqsfLKTAEVLRVSGLTQQ 118
Cdd:cd18287  90 D------LKEDVLLDVLGLAHQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128   3 DTQHFCLrwNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFR-----ELLKSTPCKhpvILLQDVN 77
Cdd:cd18259   6 DDLDFCL--PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNamftgDFVESISAR---VEIKDVD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24639128  78 FMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLR-------VSGLTQQQAEDTH 124
Cdd:cd18259  81 PAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQfptvrkvCSRYLQQQIDATN 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  34 VTLACEGRSIKAHRVVLSACSPYFRELLKSTpCKHP---VILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGG-FRESgqaEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  21 AFENLRDDEAFVDVTLAC-EGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQ 97
Cdd:cd18252  11 AFRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYFKVMFTAdmKEKSNNVIKLSGIDHDILEALVNYVYTSQICITE 90

                        90
                ....*....|....
gi 24639128  98 KSLQSFLKTAEVLR 111
Cdd:cd18252  91 RNVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  10 RWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFREL--LKSTPCKHPVILLQDVNFMDLHALVEF 87
Cdd:cd18266   4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMftIGMREAHQKEVELVGASYIGLKAVIDF 83

                        90       100
                ....*....|....*....|....*
gi 24639128  88 IYHGEVNVHQKSLQSFLKTAEVLRV 112
Cdd:cd18266  84 LYSSELPLDGGNIDYVLETAHLLQI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  16 SSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHPVILL-QDVNFMDLHALVEFIYHGEVN 94
Cdd:cd18278  16 TNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLpEEVTARGFGPLLQFAYTAKLL 95

                        90       100
                ....*....|....*....|.
gi 24639128  95 VHQKSLQSFLKTAEVLRVSGL 115
Cdd:cd18278  96 LSRENIQEVIRCAEFLRMHNL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  14 YQSSITS-----AFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYF-RELLKSTPCKHPVILLQDVNFMDLHALVEF 87
Cdd:cd18277   5 YESSVHStnvllSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFhSRIVGQADAELNITLPEEVTVKGFEPLIQF 84

                        90       100       110
                ....*....|....*....|....*....|
gi 24639128  88 IYHGEVNVHQKSLQSFLKTAEVLRVSGLTQ 117
Cdd:cd18277  85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEE 114

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  24 NLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHPVILLQD--VNFMDLHALVEFIYHGEVNVHQKSLQ 101
Cdd:cd18295  12 RLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHplVNPDAFRALLQYLYTGRLEIHVDDVE 91

                        90       100
                ....*....|....*....|..
gi 24639128 102 SFLKTAEVLRVSGLtQQQAEDT 123
Cdd:cd18295  92 DCKRLAKQCRLEEL-IEELEAK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  21 AFEN---LRDDEAFVDVTLACEGR----SIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHG 91
Cdd:cd18248   8 AFQImneLRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSglRECGMEVVPIEGVHPCVMSRLIEFAYTA 87

                        90
                ....*....|....*.
gi 24639128  92 EVNVHQKSLQSFLKTA 107
Cdd:cd18248  88 SISVGEKCVLHVLPGA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  26 RDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTpCKHPVILLQDVNFMDLHALVEFIYHGEVNVH-QKSLQSFL 104
Cdd:cd18221  13 RELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDF-TQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQgEEEANDVW 91

                ....*...
gi 24639128 105 KTAEVLRV 112
Cdd:cd18221  92 KAAEYLQM 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  13 NYQSSITSAFENLRDDEAFVDVTLACE--------GRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLH 82
Cdd:cd18273   8 AHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGglYESKQETVTIHDVDSESMA 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639128  83 ALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAedthSHLAQIQNLANSGG 138
Cdd:cd18273  88 LIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACA----SFLARRLDLSNCVG 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  12 NNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRE--LLKSTPCKHPVIllqdVNFMDLHALVEFIY 89
Cdd:cd18208   6 HNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDklLLGYSDIEIPSV----VSVQSVQKLIDFMY 81

                        90       100
                ....*....|....*....|...
gi 24639128  90 HGEVNVHQKSLQSFLKTAEVLRV 112
Cdd:cd18208  82 SGVLRVSQSEALQILTAASILQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639128  13 NYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTpckhPVILLQDVNFMD------LHALVE 86
Cdd:cd18326   7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSG----AVVDQQNVYEIDfvsaeaLTALLD 82

                        90       100
                ....*....|....*....|....*.
gi 24639128  87 FIYHGEVNVHQKSLQSFLKTAEVLRV 112
Cdd:cd18326  83 FAYTATLTVSTSNVGDILSAARLLEI 108