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Conserved domains on  [gi|442614983|ref|NP_726828|]
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uncharacterized protein Dmel_CG2694, isoform D [Drosophila melanogaster]

Protein Classification

SprT family zinc-dependent metalloprotease( domain architecture ID 10654071)

SprT-like domain-containing protein contains an HExxH motif and may function as a zinc-dependent metalloprotease; similar to DNA-dependent metalloprotease Spartan (SPRTN) that cleaves DNA-protein crosslinks (DPCs) and protects cells from DPC-induced genome instability

CATH:  3.30.2010.10
EC:  3.4.-.-
Gene Ontology:  GO:0004222|GO:0006508|GO:0046872

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
621-764 1.75e-34

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


:

Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 128.60  E-value: 1.75e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614983   621 LAKVLFNmFNHAVFHCGLQVP-IVWKHAMKKR-WKCELgfdasgrRTAQILLLHSIDTAA---ELIYLLLHEMCHVAAFL 695
Cdd:smart00731   3 LTQRLED-ASLRVFGRKLPHPkVVWNKRLRKTgGRCLL-------KSAEIRLNPKLLTENgrdRLRETLLHELCHAALYL 74
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442614983   696 FNRELGHGDNCRRWTYQAKMAFPEV--PALMECIASFMYTCSMCSRSSygLADLKSYNI---RCYYCQFEVSVK 764
Cdd:smart00731  75 FGRGYGHGDEWKRWMRQVNGLFPERchTFLIESVKKYPYRCTGCGQRY--LRVRRSNNVsryRCGKCGGKLILI 146
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
621-764 1.75e-34

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 128.60  E-value: 1.75e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614983   621 LAKVLFNmFNHAVFHCGLQVP-IVWKHAMKKR-WKCELgfdasgrRTAQILLLHSIDTAA---ELIYLLLHEMCHVAAFL 695
Cdd:smart00731   3 LTQRLED-ASLRVFGRKLPHPkVVWNKRLRKTgGRCLL-------KSAEIRLNPKLLTENgrdRLRETLLHELCHAALYL 74
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442614983   696 FNRELGHGDNCRRWTYQAKMAFPEV--PALMECIASFMYTCSMCSRSSygLADLKSYNI---RCYYCQFEVSVK 764
Cdd:smart00731  75 FGRGYGHGDEWKRWMRQVNGLFPERchTFLIESVKKYPYRCTGCGQRY--LRVRRSNNVsryRCGKCGGKLILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
625-722 2.69e-07

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 49.58  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614983  625 LFNMFNHAVF--HCGLQVPIVWKHAMKK-----RWK--CELGFdasgrrtAQILLLHSidTAAELIYLLLHEMCHVAAF- 694
Cdd:pfam10263   4 LFQQLNDEFFrgFLLPGVSVRWSKRLRTtagraHLKrkNEIRL-------SEPLLDEN--PEEFLRETLLHEMIHAYLFv 74
                          90       100
                  ....*....|....*....|....*...
gi 442614983  695 LFNRELGHGDNCRRWTYQAKMAFPEVPA 722
Cdd:pfam10263  75 LFGRRRGHGPEFKAWMERINEAQTGLPI 102
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
621-764 1.75e-34

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 128.60  E-value: 1.75e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614983   621 LAKVLFNmFNHAVFHCGLQVP-IVWKHAMKKR-WKCELgfdasgrRTAQILLLHSIDTAA---ELIYLLLHEMCHVAAFL 695
Cdd:smart00731   3 LTQRLED-ASLRVFGRKLPHPkVVWNKRLRKTgGRCLL-------KSAEIRLNPKLLTENgrdRLRETLLHELCHAALYL 74
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442614983   696 FNRELGHGDNCRRWTYQAKMAFPEV--PALMECIASFMYTCSMCSRSSygLADLKSYNI---RCYYCQFEVSVK 764
Cdd:smart00731  75 FGRGYGHGDEWKRWMRQVNGLFPERchTFLIESVKKYPYRCTGCGQRY--LRVRRSNNVsryRCGKCGGKLILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
625-722 2.69e-07

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 49.58  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614983  625 LFNMFNHAVF--HCGLQVPIVWKHAMKK-----RWK--CELGFdasgrrtAQILLLHSidTAAELIYLLLHEMCHVAAF- 694
Cdd:pfam10263   4 LFQQLNDEFFrgFLLPGVSVRWSKRLRTtagraHLKrkNEIRL-------SEPLLDEN--PEEFLRETLLHEMIHAYLFv 74
                          90       100
                  ....*....|....*....|....*...
gi 442614983  695 LFNRELGHGDNCRRWTYQAKMAFPEVPA 722
Cdd:pfam10263  75 LFGRRRGHGPEFKAWMERINEAQTGLPI 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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