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Conserved domains on  [gi|442616155|ref|NP_727644|]
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phosphodiesterase 9, isoform D [Drosophila melanogaster]

Protein Classification

3',5'-cyclic nucleotide phosphodiesterase( domain architecture ID 10446396)

3',5'-cyclic nucleotide phosphodiesterase catalyzes the hydrolysis of cAMP or cGMP to produce adenosine 5'-phosphate or guanosine 5'-phosphate, respectively

CATH:  1.10.1300.10
EC:  3.1.4.-
Gene Ontology:  GO:0046872|GO:0004114
PubMed:  11008484|9868367
SCOP:  4001423

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
739-967 7.60e-107

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 339.91  E-value: 7.60e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155   739 FHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAF 818
Cdd:pfam00233    1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155   819 RLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEI-----TPIFDYSNRAHINLLCMILIKVADISN 893
Cdd:pfam00233   81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLleskkTLDFLENEEDRRLLLLSMLIKAADISN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442616155   894 EARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMD-PDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELI 967
Cdd:pfam00233  161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDrEKKTSLPKSQIGFIDFIVLPLFEALAKLFPELQPLL 235
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
739-967 7.60e-107

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 339.91  E-value: 7.60e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155   739 FHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAF 818
Cdd:pfam00233    1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155   819 RLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEI-----TPIFDYSNRAHINLLCMILIKVADISN 893
Cdd:pfam00233   81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLleskkTLDFLENEEDRRLLLLSMLIKAADISN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442616155   894 EARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMD-PDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELI 967
Cdd:pfam00233  161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDrEKKTSLPKSQIGFIDFIVLPLFEALAKLFPELQPLL 235
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
740-913 5.96e-15

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 73.53  E-value: 5.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155  740 HNFRHCFCVAQMMYAITRQANllsrLGDLECLILLVSCICHDLDHPGYNNIYqinartelalrYNDISPLENHHCSIAFR 819
Cdd:cd00077     2 HRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAE 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155  820 LLEHPEcnifknfsrdtFNNIREGIIRCILATDMARHneiltQFMEITPIFDYSNRAHINLLCMIlIKVADISNEARPM- 898
Cdd:cd00077    67 ILRELL-----------LEEVIKLIDELILAVDASHH-----ERLDGLGYPDGLKGEEITLEARI-VKLADRLDALRRDs 129
                         170
                  ....*....|....*.
gi 442616155  899 -DVAEPWLDRLLQEFF 913
Cdd:cd00077   130 rEKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
740-904 1.85e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 65.78  E-value: 1.85e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155    740 HNFRHCFCVAQMMYAITRqanllsRLGDLECLILLVSCICHDLDHPGYNNIYQINartelalryndISPLENHHCSIAFR 819
Cdd:smart00471    4 HVFEHSLRVAQLAAALAE------ELGLLDIELLLLAALLHDIGKPGTPDSFLVK-----------TSVLEDHHFIGAEI 66
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155    820 LLEHPECNIFKNfsrdtfnniregiircILATDMARHNEILtqfmeitpifDYSNRAHINLLCMIlIKVADISNEARPMD 899
Cdd:smart00471   67 LLEEEEPRILEE----------------ILRTAILSHHERP----------DGLRGEPITLEARI-VKVADRLDALRADR 119

                    ....*
gi 442616155    900 VAEPW 904
Cdd:smart00471  120 RYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
739-967 7.60e-107

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 339.91  E-value: 7.60e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155   739 FHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAF 818
Cdd:pfam00233    1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155   819 RLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEI-----TPIFDYSNRAHINLLCMILIKVADISN 893
Cdd:pfam00233   81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLleskkTLDFLENEEDRRLLLLSMLIKAADISN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442616155   894 EARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMD-PDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELI 967
Cdd:pfam00233  161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDrEKKTSLPKSQIGFIDFIVLPLFEALAKLFPELQPLL 235
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
740-913 5.96e-15

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 73.53  E-value: 5.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155  740 HNFRHCFCVAQMMYAITRQANllsrLGDLECLILLVSCICHDLDHPGYNNIYqinartelalrYNDISPLENHHCSIAFR 819
Cdd:cd00077     2 HRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAE 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155  820 LLEHPEcnifknfsrdtFNNIREGIIRCILATDMARHneiltQFMEITPIFDYSNRAHINLLCMIlIKVADISNEARPM- 898
Cdd:cd00077    67 ILRELL-----------LEEVIKLIDELILAVDASHH-----ERLDGLGYPDGLKGEEITLEARI-VKLADRLDALRRDs 129
                         170
                  ....*....|....*.
gi 442616155  899 -DVAEPWLDRLLQEFF 913
Cdd:cd00077   130 rEKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
740-904 1.85e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 65.78  E-value: 1.85e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155    740 HNFRHCFCVAQMMYAITRqanllsRLGDLECLILLVSCICHDLDHPGYNNIYQINartelalryndISPLENHHCSIAFR 819
Cdd:smart00471    4 HVFEHSLRVAQLAAALAE------ELGLLDIELLLLAALLHDIGKPGTPDSFLVK-----------TSVLEDHHFIGAEI 66
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616155    820 LLEHPECNIFKNfsrdtfnniregiircILATDMARHNEILtqfmeitpifDYSNRAHINLLCMIlIKVADISNEARPMD 899
Cdd:smart00471   67 LLEEEEPRILEE----------------ILRTAILSHHERP----------DGLRGEPITLEARI-VKVADRLDALRADR 119

                    ....*
gi 442616155    900 VAEPW 904
Cdd:smart00471  120 RYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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