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Conserved domains on  [gi|24643238|ref|NP_728244|]
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uncharacterized protein Dmel_CG32533, isoform A [Drosophila melanogaster]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
145-619 5.18e-129

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 414.48  E-value: 5.18e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  145 NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---FGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:COG1643    9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElgwGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  222 FQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRA-RPQLKLILMSATINV 300
Cdd:COG1643   89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  301 ELFHGYFGeeGARLVQVPGRLFPIKLRYLPPPAlelkagqatskrsQRNRIDPApfvqVLSLIDQQYpTSERGDVLIFVS 380
Cdd:COG1643  169 ERFARLLG--DAPVIESSGRTYPVEVRYRPLPA-------------DERDLEDA----VADAVREAL-AEEPGDILVFLP 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  381 GVNEIESVVEAVHEYATEQThwLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNF 460
Cdd:COG1643  229 GEREIRRTAEALRGRLPPDT--EILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRY 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  461 DATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFI 540
Cdd:COG1643  307 DPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFL 386

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643238  541 EAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTD 619
Cdd:COG1643  387 DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAGSD 465
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 792-897 2.30e-08

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 52.25  E-value: 2.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    792 SGFYPQLAISDEfnyckgGGQQFFHTRLKPFVLQHPNSQFAKhfellkltesdllpkpdfytpklPLSKRHQLLCYQSLL 871
Cdd:pfam07717    7 AGLYPNVARRDP------KGKGYTTLSDNQRVFIHPSSVLFN-----------------------EKTFPPEWVVYQELV 57

                           90       100
                   ....*....|....*....|....*.
gi 24643238    872 ETAKPYLINCIRLPaAQTLLLFSFAI 897
Cdd:pfam07717   58 ETTKVYIRTVTAIS-PEWLLLFAPHI 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
145-619 5.18e-129

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 414.48  E-value: 5.18e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  145 NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---FGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:COG1643    9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElgwGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  222 FQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRA-RPQLKLILMSATINV 300
Cdd:COG1643   89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  301 ELFHGYFGeeGARLVQVPGRLFPIKLRYLPPPAlelkagqatskrsQRNRIDPApfvqVLSLIDQQYpTSERGDVLIFVS 380
Cdd:COG1643  169 ERFARLLG--DAPVIESSGRTYPVEVRYRPLPA-------------DERDLEDA----VADAVREAL-AEEPGDILVFLP 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  381 GVNEIESVVEAVHEYATEQThwLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNF 460
Cdd:COG1643  229 GEREIRRTAEALRGRLPPDT--EILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRY 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  461 DATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFI 540
Cdd:COG1643  307 DPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFL 386

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643238  541 EAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTD 619
Cdd:COG1643  387 DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAGSD 465
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 128-730 6.36e-104

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 356.39  E-value: 6.36e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    128 RQTEKFQRIRK----------LRQTQR-------NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS 190
Cdd:TIGR01967   31 RAIAALAKFREridaacdkveARRQAVpeirypdNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    191 ---IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHE 267
Cdd:TIGR01967  111 hglIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHE 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    268 RNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFgeEGARLVQVPGRLFPIKLRYLPppaLELKAGQatskrsq 347
Cdd:TIGR01967  191 RSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHF--NNAPIIEVSGRTYPVEVRYRP---LVEEQED------- 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    348 rnrIDPAPFVQVLSLIDQQYpTSERGDVLIFVSGVNEIESVVEAV--HEYAteqtHWLVLPLHSGQAIADQSKVFDyaPE 425
Cdd:TIGR01967  259 ---DDLDQLEAILDAVDELF-AEGPGDILIFLPGEREIRDAAEILrkRNLR----HTEILPLYARLSNKEQQRVFQ--PH 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    426 GMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNA 505
Cdd:TIGR01967  329 SGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    506 FEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEE---KITPLGRSLANLPVELS 582
Cdd:TIGR01967  409 RPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPR 488

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    583 IGKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVREREsLESDhgdlftLVRLYNVWVQLKMRRDGT-- 656
Cdd:TIGR01967  489 LARMLLEAHRLGCLQEVLIIASALSIQDprerPMEKQQAADQAHARFKD-PRSD------FLSRVNLWRHIEEQRQALsa 561

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643238    657 ---RQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVaSDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRK 730
Cdd:TIGR01967  562 nqfRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKL-NEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGARGRK 637
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 146-317 2.11e-100

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 314.38  E-value: 2.11e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIR 225
Cdd:cd17979    1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  226 FERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHG 305
Cdd:cd17979   81 FERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSG 160

                        170
                 ....*....|..
gi 24643238  306 YFgeEGARLVQV 317
Cdd:cd17979  161 YF--EGAPVVQV 170
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 145-611 5.07e-96

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 333.95  E-value: 5.07e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   145 NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFG---YRSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:PRK11131   72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGrgvKGLIGHTQPRRLAARTVANRIAEELETELGGCVG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   222 FQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVE 301
Cdd:PRK11131  152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPE 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   302 LFHGYFGeeGARLVQVPGRLFPIKLRYLPppaleLKAGQATSKRSQRNRIdpapFVQVLSLIDQQyptseRGDVLIFVSG 381
Cdd:PRK11131  232 RFSRHFN--NAPIIEVSGRTYPVEVRYRP-----IVEEADDTERDQLQAI----FDAVDELGREG-----PGDILIFMSG 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   382 VNEIESVVEAVHEYATEQTHwlVLPLHSGQAIADQSKVFDyaPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFD 461
Cdd:PRK11131  296 EREIRDTADALNKLNLRHTE--ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYS 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   462 ATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIE 541
Cdd:PRK11131  372 YRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVE 451

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24643238   542 APETERIEQTILALKQHCALSVEE-----KITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNP 611
Cdd:PRK11131  452 APDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDP 526
DEXDc smart00487
DEAD-like helicases superfamily;
155-327 1.83e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 90.63  E-value: 1.83e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238     155 LREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS----IACTQPRRLACVSLCKRVAHELLDDYGSRVAF------QI 224
Cdd:smart00487   17 IEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGkggrVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskRE 96

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238     225 RFERSRTKLTNILFITEGLLLRQLA-VAANLDQYDALILDEIHER--NLFGDFLLGVtkcLLRARPQLKLILMSATI--N 299
Cdd:smart00487   97 QLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAHRLldGGFGDQLEKL---LKLLPKNVQLLLLSATPpeE 173

                           170       180
                    ....*....|....*....|....*...
gi 24643238     300 VELFHGYFGEEGARLVQVPGRLFPIKLR 327
Cdd:smart00487  174 IENLLELFLNDPVFIDVGFTPLEPIEQF 201
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 555-639 3.42e-13

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 66.88  E-value: 3.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    555 LKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTN---------------RAHTD 619
Cdd:pfam04408    5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQpnfldprsaakaarrRRRAA 84

                           90       100
                   ....*....|....*....|
gi 24643238    620 QRCVRERESLESDHGDLFTL 639
Cdd:pfam04408   85 DEKARAKFARLDLEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 792-897 2.30e-08

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 52.25  E-value: 2.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    792 SGFYPQLAISDEfnyckgGGQQFFHTRLKPFVLQHPNSQFAKhfellkltesdllpkpdfytpklPLSKRHQLLCYQSLL 871
Cdd:pfam07717    7 AGLYPNVARRDP------KGKGYTTLSDNQRVFIHPSSVLFN-----------------------EKTFPPEWVVYQELV 57

                           90       100
                   ....*....|....*....|....*.
gi 24643238    872 ETAKPYLINCIRLPaAQTLLLFSFAI 897
Cdd:pfam07717   58 ETTKVYIRTVTAIS-PEWLLLFAPHI 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
145-619 5.18e-129

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 414.48  E-value: 5.18e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  145 NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---FGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:COG1643    9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElgwGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  222 FQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRA-RPQLKLILMSATINV 300
Cdd:COG1643   89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  301 ELFHGYFGeeGARLVQVPGRLFPIKLRYLPPPAlelkagqatskrsQRNRIDPApfvqVLSLIDQQYpTSERGDVLIFVS 380
Cdd:COG1643  169 ERFARLLG--DAPVIESSGRTYPVEVRYRPLPA-------------DERDLEDA----VADAVREAL-AEEPGDILVFLP 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  381 GVNEIESVVEAVHEYATEQThwLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNF 460
Cdd:COG1643  229 GEREIRRTAEALRGRLPPDT--EILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRY 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  461 DATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFI 540
Cdd:COG1643  307 DPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFL 386

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643238  541 EAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTD 619
Cdd:COG1643  387 DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAGSD 465
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 128-730 6.36e-104

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 356.39  E-value: 6.36e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    128 RQTEKFQRIRK----------LRQTQR-------NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS 190
Cdd:TIGR01967   31 RAIAALAKFREridaacdkveARRQAVpeirypdNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    191 ---IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHE 267
Cdd:TIGR01967  111 hglIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHE 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    268 RNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFgeEGARLVQVPGRLFPIKLRYLPppaLELKAGQatskrsq 347
Cdd:TIGR01967  191 RSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHF--NNAPIIEVSGRTYPVEVRYRP---LVEEQED------- 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    348 rnrIDPAPFVQVLSLIDQQYpTSERGDVLIFVSGVNEIESVVEAV--HEYAteqtHWLVLPLHSGQAIADQSKVFDyaPE 425
Cdd:TIGR01967  259 ---DDLDQLEAILDAVDELF-AEGPGDILIFLPGEREIRDAAEILrkRNLR----HTEILPLYARLSNKEQQRVFQ--PH 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    426 GMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNA 505
Cdd:TIGR01967  329 SGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    506 FEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEE---KITPLGRSLANLPVELS 582
Cdd:TIGR01967  409 RPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPR 488

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    583 IGKMLLMGSVFPEVEQLLTLAAMLSVQN----PLTNRAHTDQRCVREREsLESDhgdlftLVRLYNVWVQLKMRRDGT-- 656
Cdd:TIGR01967  489 LARMLLEAHRLGCLQEVLIIASALSIQDprerPMEKQQAADQAHARFKD-PRSD------FLSRVNLWRHIEEQRQALsa 561

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643238    657 ---RQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVaSDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRK 730
Cdd:TIGR01967  562 nqfRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKL-NEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGARGRK 637
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 146-317 2.11e-100

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 314.38  E-value: 2.11e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIR 225
Cdd:cd17979    1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  226 FERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHG 305
Cdd:cd17979   81 FERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSG 160

                        170
                 ....*....|..
gi 24643238  306 YFgeEGARLVQV 317
Cdd:cd17979  161 YF--EGAPVVQV 170
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 145-611 5.07e-96

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 333.95  E-value: 5.07e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   145 NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFG---YRSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:PRK11131   72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGrgvKGLIGHTQPRRLAARTVANRIAEELETELGGCVG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   222 FQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVE 301
Cdd:PRK11131  152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPE 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   302 LFHGYFGeeGARLVQVPGRLFPIKLRYLPppaleLKAGQATSKRSQRNRIdpapFVQVLSLIDQQyptseRGDVLIFVSG 381
Cdd:PRK11131  232 RFSRHFN--NAPIIEVSGRTYPVEVRYRP-----IVEEADDTERDQLQAI----FDAVDELGREG-----PGDILIFMSG 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   382 VNEIESVVEAVHEYATEQTHwlVLPLHSGQAIADQSKVFDyaPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFD 461
Cdd:PRK11131  296 EREIRDTADALNKLNLRHTE--ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYS 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   462 ATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIE 541
Cdd:PRK11131  372 YRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVE 451

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24643238   542 APETERIEQTILALKQHCALSVEE-----KITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNP 611
Cdd:PRK11131  452 APDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDP 526
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 322-498 2.58e-68

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 226.26  E-value: 2.58e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  322 FPIKLRYLPPPALELkagqatskRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHEYAT--EQ 399
Cdd:cd18791    1 FPVEVYYLEDILELL--------GISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLspDL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  400 THWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSA 479
Cdd:cd18791   73 GKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASA 152

                        170
                 ....*....|....*....
gi 24643238  480 DQRKGRAGRTGPGVCFRLY 498
Cdd:cd18791  153 EQRAGRAGRTRPGKCYRLY 171
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 163-317 1.60e-64

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 215.40  E-value: 1.60e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  163 RVVIVAGDTGCGKSTQVPQYLYDFGYRS-----IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNIL 237
Cdd:cd17917    2 QVVVIVGETGSGKTTQVPQFLLEDGLAKggkgrIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  238 FITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGeeGARLVQV 317
Cdd:cd17917   82 FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFG--GAPVIHI 159
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 146-606 3.87e-64

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 234.05  E-value: 3.87e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS--IACTQPRRLACVSLCKRVAHELLDDYGSRVAFQ 223
Cdd:PRK11664    4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINgkIIMLEPRRLAARNVAQRLAEQLGEKPGETVGYR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   224 IRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGD----FLLGVTKCLlraRPQLKLILMSATIN 299
Cdd:PRK11664   84 MRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADlalaLLLDVQQGL---RDDLKLLIMSATLD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   300 VELFHGYFGEegARLVQVPGRLFPIKLRYLPppaleLKAGQatskrsqrnRIDPAPFVQVLSLIDQqyptsERGDVLIFV 379
Cdd:PRK11664  161 NDRLQQLLPD--APVIVSEGRSFPVERRYQP-----LPAHQ---------RFDEAVARATAELLRQ-----ESGSLLLFL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   380 SGVNEIESVVEAVHEYATEQThwLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMN 459
Cdd:PRK11664  220 PGVGEIQRVQEQLASRVASDV--LLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVAR 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   460 FDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPF 539
Cdd:PRK11664  298 FDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSW 377

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24643238   540 IEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPevEQLLTLAAML 606
Cdd:PRK11664  378 LDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKL 442
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 146-335 2.98e-48

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 170.23  E-value: 2.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS--------IACTQPRRLACVSLCKRVAHELlDDYG 217
Cdd:cd17982    1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSpesdnpgmIGITQPRRVAAVSMAKRVAEEL-NVFG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  218 SRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQ--------- 288
Cdd:cd17982   80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 24643238  289 -LKLILMSATINVELFhgyfgeegarlVQVPgRLFPIklrylPPPALE 335
Cdd:cd17982  160 pLKLVIMSATLRVEDF-----------TENK-LLFPR-----PPPVIK 190
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 146-308 2.08e-46

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 164.45  E-value: 2.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGY---RSIACTQPRRLACVSLCKRVAHELLDDYGSRVAF 222
Cdd:cd17978    1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFargGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  223 QIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRAR-----PQLKLILMSAT 297
Cdd:cd17978   81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSAT 160

                        170
                 ....*....|.
gi 24643238  298 INVELFHGYFG 308
Cdd:cd17978  161 LDADLFSEYFN 171
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 146-309 3.59e-45

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 160.75  E-value: 3.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGY----RSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:cd17974    1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYtkggGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  222 FQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVE 301
Cdd:cd17974   81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160


                 ....*...
gi 24643238  302 LFHGYFGE 309
Cdd:cd17974  161 KFSAFFDD 168
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 134-317 3.60e-45

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 161.04  E-value: 3.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  134 QRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGY-----RSIACTQPRRLACVSLCKRV 208
Cdd:cd17973    1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELphqpkKLVACTQPRRVAAMSVAQRV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  209 AHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQ 288
Cdd:cd17973   81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160

                        170       180
                 ....*....|....*....|....*....
gi 24643238  289 LKLILMSATINVELFHGYFgeEGARLVQV 317
Cdd:cd17973  161 LKLIVMSATLDAGKFQKYF--DNAPLLKV 187
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 143-307 7.32e-45

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 159.96  E-value: 7.32e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  143 QR-NLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHELLDDYGS 218
Cdd:cd17971    2 QReSLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSrgkIGCTQPRRVAAMSVAKRVAEEFGCCLGQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  219 RVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATI 298
Cdd:cd17971   82 EVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATL 161


                 ....*....
gi 24643238  299 NVELFHGYF 307
Cdd:cd17971  162 DAVKFSQYF 170
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 146-308 4.93e-44

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 157.62  E-value: 4.93e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHELLDDYGSRVAF 222
Cdd:cd17983    1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDygmIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  223 QIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVEL 302
Cdd:cd17983   81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160


                 ....*.
gi 24643238  303 FHGYFG 308
Cdd:cd17983  161 FADFFG 166
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 146-307 4.14e-43

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 155.32  E-value: 4.14e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGY----RSIACTQPRRLACVSLCKRVAHELLDDYGSRVA 221
Cdd:cd17980    1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWtaggRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  222 FQIRFE-RSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINV 300
Cdd:cd17980   81 YCIRFDdCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160


                 ....*..
gi 24643238  301 ELFHGYF 307
Cdd:cd17980  161 EKFRDFF 167
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 146-317 8.36e-43

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 153.77  E-value: 8.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHELLDDYGSRVAF 222
Cdd:cd17989    1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIrglIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  223 QIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVEL 302
Cdd:cd17989   81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160

                        170
                 ....*....|....*
gi 24643238  303 FHGYFGeeGARLVQV 317
Cdd:cd17989  161 FSRHFN--NAPIIEV 173
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 146-308 7.38e-42

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 151.53  E-value: 7.38e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---FGYRS----IACTQPRRLACVSLCKRVAHELLDDYGS 218
Cdd:cd17985    1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDnslQGPPLpvanIICTQPRRISAISVAERVAQERAERVGQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  219 RVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATI 298
Cdd:cd17985   81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160

                        170
                 ....*....|
gi 24643238  299 NVELFHGYFG 308
Cdd:cd17985  161 NAELFSDYFN 170
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 146-308 8.40e-42

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 151.15  E-value: 8.40e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD----FGYRS---IACTQPRRLACVSLCKRVAHELLDDY-- 216
Cdd:cd17981    1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDdaieRGKGSscrIVCTQPRRISAISVAERVAAERAESCgl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  217 GSRVAFQIRFE-RSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMS 295
Cdd:cd17981   81 GNSTGYQIRLEsRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                        170
                 ....*....|...
gi 24643238  296 ATINVELFHGYFG 308
Cdd:cd17981  161 ATLNAEKFSDYFN 173
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 125-308 3.06e-41

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 151.53  E-value: 3.06e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  125 LDFRQTEKFQR-----IRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD-------FGYRSIA 192
Cdd:cd17972   33 MDLKNELMYQReqdhnLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDdfiqndrAAECNIV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  193 CTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTK-LTNILFITEGLLLRQLavAANLDQYDALILDEIHERNLF 271
Cdd:cd17972  113 VTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKL--EAGIRGISHVIVDEIHERDIN 190

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 24643238  272 GDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFG 308
Cdd:cd17972  191 TDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFF 227
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 146-308 1.35e-39

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 144.95  E-value: 1.35e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYR-----SIACTQPRRLACVSLCKRVAHELLDDYGSRV 220
Cdd:cd17988    1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKrgkycNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  221 AFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARP-QLKLILMSATIN 299
Cdd:cd17988   81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSrHVKIILMSATIS 160


                 ....*....
gi 24643238  300 VELFHGYFG 308
Cdd:cd17988  161 CKEFADYFT 169
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 146-308 1.15e-38

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 142.24  E-value: 1.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYL---YDFGYRSIAC----TQPRRLACVSLCKRVAHELLDDYGS 218
Cdd:cd17976    1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFIledYVLRGRGARCnvviTQPRRISAVSVAQRVAHELGPNLRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  219 RVAFQIRFE-RSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSAT 297
Cdd:cd17976   81 NVGYQVRLEsRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                        170
                 ....*....|.
gi 24643238  298 INVELFHGYFG 308
Cdd:cd17976  161 GDNQRLSRYFG 171
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 146-308 3.67e-38

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 140.76  E-value: 3.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHELLDDYGSRVAF 222
Cdd:cd17984    1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQhgmIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  223 QIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLL-----RARPQLKLILMSAT 297
Cdd:cd17984   81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFqekspNRKEHLKVVVMSAT 160

                        170
                 ....*....|.
gi 24643238  298 INVELFHGYFG 308
Cdd:cd17984  161 LELAKLSAFFG 171
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 146-307 3.97e-38

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 140.82  E-value: 3.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD--------FGYRSIACTQPRRLACVSLCKRVAHELLDDYG 217
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnggtAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  218 -----SRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLI 292
Cdd:cd17975   81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160

                        170
                 ....*....|....*
gi 24643238  293 LMSATINVELFHGYF 307
Cdd:cd17975  161 LMSATVDCEKFSSYF 175
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 146-308 6.96e-36

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 134.19  E-value: 6.96e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS-----IACTQPRRLACVSLCKRVAHELLDDYGSRV 220
Cdd:cd17987    1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANgipcrIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  221 AFQIRFERSRTKLTNILFITEGLLLRQL-AVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATIN 299
Cdd:cd17987   81 GYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160


                 ....*....
gi 24643238  300 VELFHGYFG 308
Cdd:cd17987  161 VNLFIRYFG 169
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 146-309 5.00e-32

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 123.21  E-value: 5.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---FGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAF 222
Cdd:cd17990    1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAelwIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  223 QIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRA-RPQLKLILMSATINVE 301
Cdd:cd17990   81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAMSATLDGD 160


                 ....*...
gi 24643238  302 LFHGYFGE 309
Cdd:cd17990  161 GLAALLPE 168
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 146-308 3.86e-28

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 111.84  E-value: 3.86e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDF----GYRS--IACTQPRRLACVSLCKRVAHELLDDYGSR 219
Cdd:cd17977    1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYclsaHYQHgvVVCTQVHKQTAVWLALRVADEMDVNIGHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  220 VAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATIN 299
Cdd:cd17977   81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160


                 ....*....
gi 24643238  300 VELFHGYFG 308
Cdd:cd17977  161 SSKLLSYYG 169
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 146-296 2.33e-23

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 98.43  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  146 LPIARFRKDLREALDT-SRVVIVAGDTGCGKSTQVPQYLYDFGYR------SIACTQPRRLACVSLCKRVAHELLDDYGS 218
Cdd:cd17986    1 LPIWAAKFTFLEQLESpSGIVLVSGEPGSGKSTQVPQWCAEFALSrgfqkgQVTVTQPHPLAARSLALRVADEMDLNLGH 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643238  219 RVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSA 296
Cdd:cd17986   81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTS 158
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 163-499 8.67e-21

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 98.51  E-value: 8.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   163 RVVIVAGDTGCGKSTQVPQYLYDFGY-----------------RSIACTQPRrlacVSLCKRVAHELL-----DDY-GSR 219
Cdd:PHA02653  180 KPVVLTGGTGVGKTSQVPKLLLWFNYlfggfdnldkidpnfieRPIVLSLPR----VALVRLHSITLLkslgfDEIdGSP 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   220 V-----AFQIRFERSRTKLTNILFITEGLLLrqlavaANLDQYDALILDEIHERNLFGDFLLGVTK---CLLRArpqlkL 291
Cdd:PHA02653  256 IslkygSIPDELINTNPKPYGLVFSTHKLTL------NKLFDYGTVIIDEVHEHDQIGDIIIAVARkhiDKIRS-----L 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   292 ILMSATI--NVELFHGYFGEegARLVQVPG-RLFPIKLRYLpppalelkagqatskrsqRNRIDPapfvqvlsLIDQQYP 368
Cdd:PHA02653  325 FLMTATLedDRDRIKEFFPN--PAFVHIPGgTLFPISEVYV------------------KNKYNP--------KNKRAYI 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238   369 TSERGDVL---------------IFVSGVNEIESVVEAVHEYATEqthWLVLPLHSG-QAIADQ-SKVFDYApegmRKCI 431
Cdd:PHA02653  377 EEEKKNIVtalkkytppkgssgiVFVASVSQCEEYKKYLEKRLPI---YDFYIIHGKvPNIDEIlEKVYSSK----NPSI 449

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24643238   432 -VSTNIAETSLTVDGVRFVVDSGKV--KEMnFDAtckgqrlKEFWVSKSSADQRKGRAGRTGPGVCFRLYT 499
Cdd:PHA02653  450 iISTPYLESSVTIRNATHVYDTGRVyvPEP-FGG-------KEMFISKSMRTQRKGRVGRVSPGTYVYFYD 512
DEXDc smart00487
DEAD-like helicases superfamily;
155-327 1.83e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 90.63  E-value: 1.83e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238     155 LREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS----IACTQPRRLACVSLCKRVAHELLDDYGSRVAF------QI 224
Cdd:smart00487   17 IEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGkggrVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskRE 96

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238     225 RFERSRTKLTNILFITEGLLLRQLA-VAANLDQYDALILDEIHER--NLFGDFLLGVtkcLLRARPQLKLILMSATI--N 299
Cdd:smart00487   97 QLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAHRLldGGFGDQLEKL---LKLLPKNVQLLLLSATPpeE 173

                           170       180
                    ....*....|....*....|....*...
gi 24643238     300 VELFHGYFGEEGARLVQVPGRLFPIKLR 327
Cdd:smart00487  174 IENLLELFLNDPVFIDVGFTPLEPIEQF 201
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 560-640 1.98e-15

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 72.30  E-value: 1.98e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238     560 ALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNraHTDQRCVRERESLESDHGDLFTL 639
Cdd:smart00847    4 ALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK--EKREDADAARRRFADPESDHLTL 81


                    .
gi 24643238     640 V 640
Cdd:smart00847   82 L 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 555-639 3.42e-13

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 66.88  E-value: 3.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    555 LKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTN---------------RAHTD 619
Cdd:pfam04408    5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQpnfldprsaakaarrRRRAA 84

                           90       100
                   ....*....|....*....|
gi 24643238    620 QRCVRERESLESDHGDLFTL 639
Cdd:pfam04408   85 DEKARAKFARLDLEGDHLTL 104
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 358-490 4.96e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 63.38  E-value: 4.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    358 QVLSLIDQQYPTSERGDVLIFVSGVNEIESvveavhEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIA 437
Cdd:pfam00271    1 EKLEALLELLKKERGGKVLIFSQTKKTLEA------ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVA 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24643238    438 ETSLTVDGVRFVVdsgkvkemNFDAtckgqrlkefWVSKSSADQRKGRAGRTG 490
Cdd:pfam00271   75 ERGLDLPDVDLVI--------NYDL----------PWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
404-490 2.77e-11

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 60.69  E-value: 2.77e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238     404 VLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGkvkemnfdatckgqrlkeFWVSKSSADQRK 483
Cdd:smart00490   14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWSPASYIQRI 75


                    ....*..
gi 24643238     484 GRAGRTG 490
Cdd:smart00490   76 GRAGRAG 82
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 792-897 2.30e-08

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 52.25  E-value: 2.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    792 SGFYPQLAISDEfnyckgGGQQFFHTRLKPFVLQHPNSQFAKhfellkltesdllpkpdfytpklPLSKRHQLLCYQSLL 871
Cdd:pfam07717    7 AGLYPNVARRDP------KGKGYTTLSDNQRVFIHPSSVLFN-----------------------EKTFPPEWVVYQELV 57

                           90       100
                   ....*....|....*....|....*.
gi 24643238    872 ETAKPYLINCIRLPaAQTLLLFSFAI 897
Cdd:pfam07717   58 ETTKVYIRTVTAIS-PEWLLLFAPHI 82
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 157-302 2.67e-07

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 51.47  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    157 EALDTSRVVIVAGDTGCGKST--QVP--QYLYD-FGYRSIACTQPRRlacvSLCK---RVAHELLDDYGSRVAF-----Q 223
Cdd:pfam00270    9 PAILEGRDVLVQAPTGSGKTLafLLPalEALDKlDNGPQALVLAPTR----ELAEqiyEELKKLGKGLGLKVASllggdS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238    224 IRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHE--RNLFGDfllGVTKCLLRARPQLKLILMSATINVE 301
Cdd:pfam00270   85 RKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGP---DLEEILRRLPKKRQILLLSATLPRN 161


                   .
gi 24643238    302 L 302
Cdd:pfam00270  162 L 162
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 165-297 6.50e-05

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 44.32  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  165 VIVAGDTGCGKSTQVP----QYLYDFGYRsIACTQPRRlacvSLCKRVAHELLD--DYGSRVAFQIRFERSRTKLTN--- 235
Cdd:cd00046    4 VLITAPTGSGKTLAALlaalLLLLKKGKK-VLVLVPTK----ALALQTAERLRElfGPGIRVAVLVGGSSAEEREKNklg 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643238  236 ---ILFITEGLLLR--QLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRA-RPQLKLILMSAT 297
Cdd:cd00046   79 dadIIIATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAgLKNAQVILLSAT 146
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 431-498 7.82e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 39.22  E-value: 7.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643238  431 IVSTNIAETSLTVDGVRFVVDSGKVKemnfdatckgqrlkefwvSKSSADQRKGRAGRTG--PGVCFRLY 498
Cdd:cd18785   26 LVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGGkdEGEVILFV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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