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Conserved domains on  [gi|24655113|ref|NP_728591|]
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HECT and RLD domain containing E3 ubiquitin ligase 4, isoform A [Drosophila melanogaster]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18806229)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 711-1056 1.27e-148

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 447.01  E-value: 1.27e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  711 IVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQS-RLLWFADL 789
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  790 TFETEN---MYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDfkEVFDLTF 866
Cdd:cd00078   81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDE--DDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  867 EISRDV-FGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVG 945
Cdd:cd00078  159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  946 NEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTP-DERFLPV 1022
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGsPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 24655113 1023 AHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFS 1056
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-347 1.63e-88

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 288.03  E-value: 1.63e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    7 LYCWGSTSHGQLGLGGIEDEqiLTPSQIPWTPDtaVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR--PLLI 84
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDR--STPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRttPVKV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113   85 PELQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEiVQLPKVVRQLVTkTVVQIACGNNHSLALTSCGEL 164
Cdd:COG5184   95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN-RLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  165 YSWGSNIYGQLGVNSPNDLThcnYPLRLTTLLGIplAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 244
Cdd:COG5184  171 WCWGANSYGQLGDGTTTDRP---TPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  245 KTLRtlGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELmgSTITQVACGNRHTLALVPSrGRV 324
Cdd:COG5184  246 AGLT--GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCALLTD-GTV 320

                        330       340
                 ....*....|....*....|...
gi 24655113  325 YAFGLGSSGQLGTRSTKSLMLPQ 347
Cdd:COG5184  321 WCWGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
322-385 4.60e-05

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 41.73  E-value: 4.60e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655113    322 GRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPwvspsgsallqsndsqVSLVIRQIFSGGDQSIV 385
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL----------------SGNKVVQVACGGDHTVA 49
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 711-1056 1.27e-148

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 447.01  E-value: 1.27e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  711 IVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQS-RLLWFADL 789
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  790 TFETEN---MYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDfkEVFDLTF 866
Cdd:cd00078   81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDE--DDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  867 EISRDV-FGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVG 945
Cdd:cd00078  159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  946 NEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTP-DERFLPV 1022
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGsPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 24655113 1023 AHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFS 1056
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 772-1058 4.99e-114

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 354.61  E-value: 4.99e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    772 YGMFK-EYEQSRLLWFADLTFETE-----NMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEAN 845
Cdd:pfam00632   12 YGLFEyETEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPELYK 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    846 SMQSLLDYQGDDfKEVFDLTFEIsrDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKV 925
Cdd:pfam00632   92 SLKSLLNMDNDD-DEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGFYSV 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    926 CSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMK 1005
Cdd:pfam00632  169 IPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFK 248

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24655113   1006 AL-KLTIQ--PTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1058
Cdd:pfam00632  249 SLpKFTIVrkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 735-1055 1.00e-113

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 354.62  E-value: 1.00e-113
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     735 DLKKP-LKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETE----NMYFLIGVLCGLAIY 809
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     810 NFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSL-LDYQGDDfkeVFDLTFEISRD-VFGEAETKCLKPNGNE 887
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSE---ELDLTFSIVLTsEFGQVKVVELKPGGSN 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     888 IAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSV 967
Cdd:smart00119  158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     968 DDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTP-DERFLPVAHTCFNLLDLPRYKTKERLKYK 1044
Cdd:smart00119  238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGsDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                           330
                    ....*....|.
gi 24655113    1045 LLQAIQQTQGF 1055
Cdd:smart00119  318 LLLAINEGKGF 328
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
698-1057 3.32e-97

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 327.88  E-value: 3.32e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  698 FSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKE 777
Cdd:COG5021  502 YSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEY 581

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  778 YEQSRLLW----FADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDY 853
Cdd:COG5021  582 ITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNN 661

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  854 QGDDFkeVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHI 933
Cdd:COG5021  662 DIDET--ILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQI 739

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  934 FQPEELMAVVVG-NEDYDWQALQDNCEYReGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQ 1012
Cdd:COG5021  740 FDESELELLIGGiPEDIDIDDWKSNTAYH-GYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDG 818

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 24655113 1013 P---------TPDERfLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1057
Cdd:COG5021  819 VrkftiekggTDDDR-LPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGL 871
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-347 1.63e-88

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 288.03  E-value: 1.63e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    7 LYCWGSTSHGQLGLGGIEDEqiLTPSQIPWTPDtaVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR--PLLI 84
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDR--STPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRttPVKV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113   85 PELQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEiVQLPKVVRQLVTkTVVQIACGNNHSLALTSCGEL 164
Cdd:COG5184   95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN-RLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  165 YSWGSNIYGQLGVNSPNDLThcnYPLRLTTLLGIplAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 244
Cdd:COG5184  171 WCWGANSYGQLGDGTTTDRP---TPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  245 KTLRtlGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELmgSTITQVACGNRHTLALVPSrGRV 324
Cdd:COG5184  246 AGLT--GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCALLTD-GTV 320

                        330       340
                 ....*....|....*....|...
gi 24655113  325 YAFGLGSSGQLGTRSTKSLMLPQ 347
Cdd:COG5184  321 WCWGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
268-317 1.11e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.08  E-value: 1.11e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 24655113    268 EGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLAL 317
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
322-385 4.60e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 41.73  E-value: 4.60e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655113    322 GRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPwvspsgsallqsndsqVSLVIRQIFSGGDQSIV 385
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL----------------SGNKVVQVACGGDHTVA 49
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 711-1056 1.27e-148

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 447.01  E-value: 1.27e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  711 IVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQS-RLLWFADL 789
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  790 TFETEN---MYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDfkEVFDLTF 866
Cdd:cd00078   81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDE--DDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  867 EISRDV-FGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVG 945
Cdd:cd00078  159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  946 NEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTP-DERFLPV 1022
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGsPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 24655113 1023 AHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFS 1056
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 772-1058 4.99e-114

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 354.61  E-value: 4.99e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    772 YGMFK-EYEQSRLLWFADLTFETE-----NMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEAN 845
Cdd:pfam00632   12 YGLFEyETEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPELYK 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    846 SMQSLLDYQGDDfKEVFDLTFEIsrDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKV 925
Cdd:pfam00632   92 SLKSLLNMDNDD-DEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGFYSV 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    926 CSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMK 1005
Cdd:pfam00632  169 IPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFK 248

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24655113   1006 AL-KLTIQ--PTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSLV 1058
Cdd:pfam00632  249 SLpKFTIVrkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 735-1055 1.00e-113

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 354.62  E-value: 1.00e-113
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     735 DLKKP-LKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETE----NMYFLIGVLCGLAIY 809
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     810 NFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSL-LDYQGDDfkeVFDLTFEISRD-VFGEAETKCLKPNGNE 887
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSE---ELDLTFSIVLTsEFGQVKVVELKPGGSN 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     888 IAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSV 967
Cdd:smart00119  158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113     968 DDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTP-DERFLPVAHTCFNLLDLPRYKTKERLKYK 1044
Cdd:smart00119  238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGsDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                           330
                    ....*....|.
gi 24655113    1045 LLQAIQQTQGF 1055
Cdd:smart00119  318 LLLAINEGKGF 328
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
698-1057 3.32e-97

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 327.88  E-value: 3.32e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  698 FSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKE 777
Cdd:COG5021  502 YSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEY 581

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  778 YEQSRLLW----FADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDY 853
Cdd:COG5021  582 ITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNN 661

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  854 QGDDFkeVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHI 933
Cdd:COG5021  662 DIDET--ILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQI 739

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  934 FQPEELMAVVVG-NEDYDWQALQDNCEYReGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQ 1012
Cdd:COG5021  740 FDESELELLIGGiPEDIDIDDWKSNTAYH-GYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDG 818

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 24655113 1013 P---------TPDERfLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1057
Cdd:COG5021  819 VrkftiekggTDDDR-LPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGL 871
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 7-347 1.63e-88

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 288.03  E-value: 1.63e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    7 LYCWGSTSHGQLGLGGIEDEqiLTPSQIPWTPDtaVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR--PLLI 84
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDR--STPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRttPVKV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113   85 PELQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEiVQLPKVVRQLVTkTVVQIACGNNHSLALTSCGEL 164
Cdd:COG5184   95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN-RLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  165 YSWGSNIYGQLGVNSPNDLThcnYPLRLTTLLGIplAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 244
Cdd:COG5184  171 WCWGANSYGQLGDGTTTDRP---TPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  245 KTLRtlGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELmgSTITQVACGNRHTLALVPSrGRV 324
Cdd:COG5184  246 AGLT--GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCALLTD-GTV 320

                        330       340
                 ....*....|....*....|...
gi 24655113  325 YAFGLGSSGQLGTRSTKSLMLPQ 347
Cdd:COG5184  321 WCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 43-355 8.71e-77

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 256.06  E-value: 8.71e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113   43 QQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR--PLLIPELQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCG 120
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRstPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  121 QLGHATdKEIVQLPKVVRQLvtKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGvnsPNDLTHCNYPLRLTTLLGiPL 200
Cdd:COG5184   79 QLGDGT-TTDRTTPVKVPGL--TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNRLTPVQVDAGLS-GV 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  201 AAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRtlGVRFVACGDEFSVFLTNEGGVFTCGAGAYG 280
Cdd:COG5184  152 VAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24655113  281 QLGHGFSSNEMLPRMVmeLMGSTITQVACGNRHTLALVPSrGRVYAFGLGSSGQLGTRSTKSLMLPQVVIG--PWVS 355
Cdd:COG5184  230 QLGDGTTTDRATPVQV--AGLTGVVAIAAGGSHTCALKSD-GTVWCWGDNSYGQLGDGTTTDRSTPVKVPGlsGVVA 303
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 6-293 1.05e-73

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 247.58  E-value: 1.05e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    6 ELYCWGSTSHGQLGLGGIEDEqiLTPSQIPWTPDtaVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR--PLL 83
Cdd:COG5184   68 TVWCWGNNSYGQLGDGTTTDR--TTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRltPVQ 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113   84 IPE-LQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEiVQLPKVVRQLvtKTVVQIACGNNHSLALTSCG 162
Cdd:COG5184  144 VDAgLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTD-RPTPVQVGGL--SGVVAVAAGGDHSCALKSDG 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113  163 ELYSWGSNIYGQLGVNSPNDLThcnYPLRLTTLLGIplAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPT 242
Cdd:COG5184  219 TVWCWGSNSSGQLGDGTTTDRA---TPVQVAGLTGV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPV 293

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24655113  243 QLKTLrtLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLP 293
Cdd:COG5184  294 KVPGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 6-242 4.30e-58

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 203.67  E-value: 4.30e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    6 ELYCWGSTSHGQLGLGGIEDEqiLTPSQIPWTPDTAVQqVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR--PLL 83
Cdd:COG5184  118 TVWCWGDNSSGQLGDGTTTNR--LTPVQVDAGLSGVVA-IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRptPVQ 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113   84 IPELQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVqLPKVVRQLVTktVVQIACGNNHSLALTSCGE 163
Cdd:COG5184  195 VGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRA-TPVQVAGLTG--VVAIAAGGSHTCALKSDGT 269

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24655113  164 LYSWGSNIYGQLGVNSPNDLThcnYPLRLTTLLGIplAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPT 242
Cdd:COG5184  270 VWCWGDNSYGQLGDGTTTDRS---TPVKVPGLSGV--VAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2-126 2.12e-28

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 117.77  E-value: 2.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655113    2 ASGKELYCWGSTSHGQLGLGGIEDEqiLTPSQIPwtPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKR- 80
Cdd:COG5184  215 KSDGTVWCWGSNSSGQLGDGTTTDR--ATPVQVA--GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRs 290

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 24655113   81 -PLLIPELQDyvIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHAT 126
Cdd:COG5184  291 tPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGT 335
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
268-317 1.11e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.08  E-value: 1.11e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 24655113    268 EGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLAL 317
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
216-265 1.72e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 65.62  E-value: 1.72e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 24655113    216 SGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFL 265
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
109-158 2.83e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.15  E-value: 2.83e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 24655113    109 GQVLSWGDNDCGQLGHATDKEiVQLPKVVRQLVTKTVVQIACGNNHSLAL 158
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
6-55 1.17e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 1.17e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 24655113      6 ELYCWGSTSHGQLGLGGIEDEqiLTPSQIPWTPDTAVQQVACGHRHTLFL 55
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTTENV--LVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
162-213 2.34e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.45  E-value: 2.34e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24655113    162 GELYSWGSNIYGQLGVNSPNDlthCNYPLRLTTLLGIPLAAIACGGNHSFLI 213
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTEN---VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
59-105 2.80e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.37  E-value: 2.80e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 24655113     59 GKVYACGSNDYSQLGHDLPTKR--PLLIPELQDYVIIQICCGSRHSLAL 105
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVlvPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
145-174 6.06e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 55.12  E-value: 6.06e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 24655113    145 VVQIACGNNHSLALTSCGELYSWGSNIYGQ 174
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
42-71 1.14e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 51.27  E-value: 1.14e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 24655113     42 VQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
92-121 1.34e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 51.27  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 24655113     92 IIQICCGSRHSLALSDWGQVLSWGDNDCGQ 121
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
201-229 5.89e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 49.34  E-value: 5.89e-08
                           10        20
                   ....*....|....*....|....*....
gi 24655113    201 AAIACGGNHSFLISKSGAVFGWGRNNCGQ 229
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
304-334 2.41e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.72  E-value: 2.41e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24655113    304 ITQVACGNRHTLALVpSRGRVYAFGLGSSGQ 334
Cdd:pfam13540    1 VVSVAAGDNHTLALT-SDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
252-281 2.99e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.64  E-value: 2.99e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 24655113    252 VRFVACGDEFSVFLTNEGGVFTCGAGAYGQ 281
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
322-385 4.60e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 41.73  E-value: 4.60e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655113    322 GRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPwvspsgsallqsndsqVSLVIRQIFSGGDQSIV 385
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL----------------SGNKVVQVACGGDHTVA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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