NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24655937|ref|NP_728726|]
View 

uncharacterized protein Dmel_CG1275, isoform C [Drosophila melanogaster]

Protein Classification

cytochrome b family protein; cytochrome b/b6( domain architecture ID 10171796)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.| cytochrome b/b6 (PetB) is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme; cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes; in plants and cyanobacteria, cytochrome b6 is analogous to cytochrome b and contains two chains: helices A-D (encoded by petB) and helices E-H (encoded by petD)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 34-250 3.74e-117

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176494  Cd Length: 214  Bit Score: 333.91  E-value: 3.74e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  34 IVLVATWIGQHFGGLAGTsNPGVEFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTLKLTHAGIHMGAFILTVIALKTV 113
Cdd:cd08764   1 VVLVGIWLGKFRGGFSWT-GPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937 114 FDSHNLANPPIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKA 193
Cdd:cd08764  80 FDSHNLAKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEKA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24655937 194 IFAIKTpaYSTLPPAGVLANVIGVMYVVFGALVVYLATEPSYKRKPIPEDTALLNSS 250
Cdd:cd08764 160 FFSLNK--YSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRIELPEEEELLIQN 214
 
Name Accession Description Interval E-value
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 34-250 3.74e-117

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 333.91  E-value: 3.74e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  34 IVLVATWIGQHFGGLAGTsNPGVEFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTLKLTHAGIHMGAFILTVIALKTV 113
Cdd:cd08764   1 VVLVGIWLGKFRGGFSWT-GPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937 114 FDSHNLANPPIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKA 193
Cdd:cd08764  80 FDSHNLAKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEKA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24655937 194 IFAIKTpaYSTLPPAGVLANVIGVMYVVFGALVVYLATEPSYKRKPIPEDTALLNSS 250
Cdd:cd08764 160 FFSLNK--YSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRIELPEEEELLIQN 214
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 60-195 5.30e-54

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 170.87  E-value: 5.30e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937    60 WHPLFMTIGFIYLYGNSILIYRG--FRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWLGLS 137
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVnsTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSG--IPHFYSLHSWLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24655937   138 AVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKAIF 195
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIF 136
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 60-189 2.10e-39

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 133.13  E-value: 2.10e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937     60 WHPLFMTIGFIYLYGNSILIYR-GFRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWLGLSA 138
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESG--IANFYSLHSWLGLAA 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 24655937    139 VIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGI 189
Cdd:smart00665  79 FVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 12-241 7.71e-38

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 132.62  E-value: 7.71e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   12 MDPALINFKVLyVLTQLCGLTMIVLVATWIGQHFGGLAGTS-NPGVEFNWHPLFMTIGFIYLYGNSILIYRGFRTTrKKT 90
Cdd:PLN02680   1 MAVPVIRFPIF-MLVRLLGVIVAALVLTWTVHYRGGLALSSdNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVPGT-KNL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   91 LKLTHAGIHMGAFILTVIALKTVFDSHNlaNPPIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLH 170
Cdd:PLN02680  79 KKLVHLTLQFLAFCLSLIGVWAALKFHN--EKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWH 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24655937  171 IYFGLFGFVLAIASALMGITEKAIFAIKTPAYSTLPPAGVLANVIGVMYVVFGALVVYLATEPSYKRKPIP 241
Cdd:PLN02680 157 VFFGIYIYALAVATATTGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTPLNGKGDVL 227
 
Name Accession Description Interval E-value
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 34-250 3.74e-117

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 333.91  E-value: 3.74e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  34 IVLVATWIGQHFGGLAGTsNPGVEFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTLKLTHAGIHMGAFILTVIALKTV 113
Cdd:cd08764   1 VVLVGIWLGKFRGGFSWT-GPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937 114 FDSHNLANPPIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKA 193
Cdd:cd08764  80 FDSHNLAKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEKA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24655937 194 IFAIKTpaYSTLPPAGVLANVIGVMYVVFGALVVYLATEPSYKRKPIPEDTALLNSS 250
Cdd:cd08764 160 FFSLNK--YSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRIELPEEEELLIQN 214
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 60-195 5.30e-54

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 170.87  E-value: 5.30e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937    60 WHPLFMTIGFIYLYGNSILIYRG--FRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWLGLS 137
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVnsTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSG--IPHFYSLHSWLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24655937   138 AVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKAIF 195
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIF 136
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 57-189 3.33e-48

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 155.52  E-value: 3.33e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  57 EFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNlaNPPIPNMYSLHSWLGL 136
Cdd:cd08554   1 EFNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHN--AGGIANLYSLHSWLGL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24655937 137 SAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGI 189
Cdd:cd08554  79 ATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 57-198 1.71e-43

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 144.65  E-value: 1.71e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  57 EFNWHPLFMTIGFIYLYGNSILIYRGFRTTR--KKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWL 134
Cdd:cd08765  11 EFNWHPVLMVIGFIFIQGIAIIVYRLPWTWKcsKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKN--IPNMYSLHSWV 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655937 135 GLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKAIFAIK 198
Cdd:cd08765  89 GLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSLK 152
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 52-195 9.13e-40

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 134.74  E-value: 9.13e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  52 SNPGVEFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKkTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLH 131
Cdd:cd08766   2 DNKGLIFNVHPVLMVIGFIFLAGEAILAYKTVPGSRE-VQKAVHLTLHLVALVLGIVGIYAAFKFHNEVG--IPNLYSLH 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24655937 132 SWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKAIF 195
Cdd:cd08766  79 SWLGIGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTF 142
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 60-189 2.10e-39

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 133.13  E-value: 2.10e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937     60 WHPLFMTIGFIYLYGNSILIYR-GFRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWLGLSA 138
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESG--IANFYSLHSWLGLAA 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 24655937    139 VIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGI 189
Cdd:smart00665  79 FVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 12-241 7.71e-38

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 132.62  E-value: 7.71e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   12 MDPALINFKVLyVLTQLCGLTMIVLVATWIGQHFGGLAGTS-NPGVEFNWHPLFMTIGFIYLYGNSILIYRGFRTTrKKT 90
Cdd:PLN02680   1 MAVPVIRFPIF-MLVRLLGVIVAALVLTWTVHYRGGLALSSdNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVPGT-KNL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   91 LKLTHAGIHMGAFILTVIALKTVFDSHNlaNPPIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLH 170
Cdd:PLN02680  79 KKLVHLTLQFLAFCLSLIGVWAALKFHN--EKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWH 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24655937  171 IYFGLFGFVLAIASALMGITEKAIFAIKTPAYSTLPPAGVLANVIGVMYVVFGALVVYLATEPSYKRKPIP 241
Cdd:PLN02680 157 VFFGIYIYALAVATATTGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTPLNGKGDVL 227
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 23-198 1.37e-34

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 122.28  E-value: 1.37e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  23 YVLTQLCGLTMIVLVATWIGQHFGGLA--GTSNpgvEFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTL--KLTHAGI 98
Cdd:cd08762   1 CLLLGILGIACVVLVVHWNQMWRGGFAwdGSSK---NFNWHPVLMVTGMVVLYGNAALVYRIPLTWGGPKLpwKLLHAGL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  99 HMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGF 178
Cdd:cd08762  78 LLLAFILTVIGLCAVFNFHNVHH--TANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMIL 155

                       170       180
                ....*....|....*....|
gi 24655937 179 VLAIASALMGITEKAIFAIK 198
Cdd:cd08762 156 VLSIASCISGINEKLFFSLK 175
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 56-195 6.32e-34

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 119.53  E-value: 6.32e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  56 VEFNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANppIPNMYSLHSWLG 135
Cdd:cd08763   5 LQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANG--YPDMYSLHSWCG 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937 136 LSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKAIF 195
Cdd:cd08763  83 ILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
PLN02810 PLN02810
carbon-monoxide oxygenase
 35-227 9.66e-29

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 108.75  E-value: 9.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   35 VLVATWIGQHFGGLA-GTSNPGVEFNWHPLFMTIGFIYLYGNSILIYRGFrTTRKKTLKLTHAGIHMGAFILTVIALKTV 113
Cdd:PLN02810  23 IMVLVWSIYYRGGLAwEATNKNLIFNLHPVLMLIGLIIIGGEAIMSYKSL-PLKKEVKKLIHLVLHAIALILGIFGICAA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  114 FDSHNLANppIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKA 193
Cdd:PLN02810 102 FKNHNESG--IANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFGLFVYILAVGNAALGFLEKL 179

                        170       180       190
                 ....*....|....*....|....*....|....
gi 24655937  194 IFaIKTPAYSTLPPAGVLANVIGVMYVVFGALVV 227
Cdd:PLN02810 180 TF-LESGGLDKYGSEALLVNFTAIITILYGAFVV 212
PLN02351 PLN02351
cytochromes b561 family protein
 22-239 1.36e-22

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 92.66  E-value: 1.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   22 LYVLTQLCGLTMIVLVATWIGQHFGGLAGTSNPGVEFNW---HPLFMTIGFIYLYGNSILIYRGFRTTRKkTLKLTHAGI 98
Cdd:PLN02351  12 LLLFARLSGLVVAVLVLYWALFFKSSFLPQSTSQEDLVYavlHPLLMVIGFILISGEAILVHRWLPGSRK-TKKSVHLWL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937   99 HMGAFILTVIALKTVFDSHNLAnppIPNMYSLHSWLGLSAVIVFSLQYVAGFVAFLAPGLRENYRIAMMPLHIYFGLFGF 178
Cdd:PLN02351  91 QGLALASGVFGIWTKFHGQDGI---VANFYSLHSWMGLICVSLFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVFLGLYTY 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24655937  179 VLAIASALMGITEKAIFAIKTPAYSTLPPAGVLANVIGVMYVVFGALVVYLATEPSYKRKP 239
Cdd:PLN02351 168 GLAVATAETGLLEKLTFLQTKRNVSKHGSESMVVNGLGLGLALLSGIVILAAVLPKYQSHS 228
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 58-188 1.97e-13

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 66.54  E-value: 1.97e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  58 FNWHPLFMTIGFIYLYGNSILIYRG---FRTTRKKTLKLTHAGIHMGAFILTVIALKTVFDSHNLANPPipNMYSLHSWL 134
Cdd:cd08761  21 FSWHPLLMSLGFLLLMTEALLLLQPtssLTKLARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKP--HFTSWHGIL 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24655937 135 GLSAVIVFSLQYVAGFVAFLAPGLRENYR--IAMMPLHIYFGLFGFVLAIASALMG 188
Cdd:cd08761  99 GLVTVILIVLQALGGLALLYPPGLRRGESkaKKLKKYHRLSGYVAYLLGLATLVLG 154
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 58-227 2.01e-06

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 46.95  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937  58 FNWHPLFMTIGFIYLYGNSILIYRGFRTTRKKTLKLtHAGIHMGAFILTVIALKTVFdshNLANPPIPNMYSLHSWLGLS 137
Cdd:cd08760  36 IKAHGVLMAIAWGILMPIGALLARYFLLGDPVWFYL-HAGLQLLAVLLAIAGFVLGI---VLVQGGGGSLNNAHAILGII 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655937 138 AVIVFSLQyvaGFVAFLAPGLRENYRIAMMPLHIYFGLFGFVLAIASALMGITEKAIFAIKTPAYstlppagVLANVIGV 217
Cdd:cd08760 112 VLALAILQ---PLLGLLRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGLDLAGAGTPKAWKI-------AYGVVVAV 181

                       170
                ....*....|
gi 24655937 218 MYVVFGALVV 227
Cdd:cd08760 182 LALVYLILEI 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH