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Conserved domains on  [gi|24657033|ref|NP_728910|]
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maggie, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TOM22 cd22884
Mitochondrial import receptor subunit TOM22 and similar proteins; Mitochondrial import ...
 31-97 2.81e-25

Mitochondrial import receptor subunit TOM22 and similar proteins; Mitochondrial import receptor subunit TOM22, also called mitochondrial 17 kDa assembly protein, mitochondrial 22 kDa outer membrane protein (MOM22), protein MAS17, or translocase of outer membrane (TOM) 22 kDa subunit, is the central component of the TOM receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. It may regulate the TOM machinery organization, stability and channel gating. Together with TOM20 and TOM70, TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. The N-terminal region of TOM22 has been shown to have chaperone-like activity, and the C-terminal region faces the intermembrane face.


:

Pssm-ID: 439375  Cd Length: 67  Bit Score: 90.29  E-value: 2.81e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24657033  31 WGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAPVIFETERAQMEELHKSQ 97
Cdd:cd22884   1 AALKDIFPPSVRSAISSAASSTVSVAKKLLSFSGKAAWVLSTSALLLGVPLALEIEREQQLEEQEKQ 67
 
Name Accession Description Interval E-value
TOM22 cd22884
Mitochondrial import receptor subunit TOM22 and similar proteins; Mitochondrial import ...
 31-97 2.81e-25

Mitochondrial import receptor subunit TOM22 and similar proteins; Mitochondrial import receptor subunit TOM22, also called mitochondrial 17 kDa assembly protein, mitochondrial 22 kDa outer membrane protein (MOM22), protein MAS17, or translocase of outer membrane (TOM) 22 kDa subunit, is the central component of the TOM receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. It may regulate the TOM machinery organization, stability and channel gating. Together with TOM20 and TOM70, TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. The N-terminal region of TOM22 has been shown to have chaperone-like activity, and the C-terminal region faces the intermembrane face.


Pssm-ID: 439375  Cd Length: 67  Bit Score: 90.29  E-value: 2.81e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24657033  31 WGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAPVIFETERAQMEELHKSQ 97
Cdd:cd22884   1 AALKDIFPPSVRSAISSAASSTVSVAKKLLSFSGKAAWVLSTSALLLGVPLALEIEREQQLEEQEKQ 67
3a0801s05tom22 TIGR00986
mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase (MPT) ...
 5-119 3.97e-06

mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tom22 proteins. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273379  Cd Length: 145  Bit Score: 43.03  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657033     5 NEGKTSNDPQRENYDDEPDETASERFWGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAPVIFE 84
Cdd:TIGR00986  30 FTDVDSEDSVDSDFESLEEETFTDRIYALKDIVPPTTRGWIYHKYSTTTNFVKSTLSFAGRAAWAVSTSALLLGVPFAIS 109

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 24657033    85 -TERAQMEELHKSQQKQVllGPGSAMGPGGPSPSLP 119
Cdd:TIGR00986 110 fAEEQQLAEMEKEARMQE--LANDVLAAGGEGQAGT 143
Tom22 pfam04281
Mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase family, ...
 19-100 4.07e-06

Mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase family, which is responsible for movement of nuclear encoded pre-proteins into mitochondria, is very complex with at least 19 components. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family represents the Tom22 proteins. The N terminal region of Tom22 has been shown to have chaperone-like activity, and the C terminal region faces the intermembrane face.


Pssm-ID: 427836  Cd Length: 138  Bit Score: 42.96  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657033    19 DDEPDETASERFWGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAP--VIFETErAQMEELHKS 96
Cdd:pfam04281  48 FDPENETLYDRIAALKDIIPPTTRGSISSKFSTTTSFVKSGFSFGGKLLWVVTTSALLLGVPlaLAILEE-QQLVEMEKE 126


                  ....
gi 24657033    97 QQKQ 100
Cdd:pfam04281 127 MRMQ 130
 
Name Accession Description Interval E-value
TOM22 cd22884
Mitochondrial import receptor subunit TOM22 and similar proteins; Mitochondrial import ...
 31-97 2.81e-25

Mitochondrial import receptor subunit TOM22 and similar proteins; Mitochondrial import receptor subunit TOM22, also called mitochondrial 17 kDa assembly protein, mitochondrial 22 kDa outer membrane protein (MOM22), protein MAS17, or translocase of outer membrane (TOM) 22 kDa subunit, is the central component of the TOM receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. It may regulate the TOM machinery organization, stability and channel gating. Together with TOM20 and TOM70, TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. The N-terminal region of TOM22 has been shown to have chaperone-like activity, and the C-terminal region faces the intermembrane face.


Pssm-ID: 439375  Cd Length: 67  Bit Score: 90.29  E-value: 2.81e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24657033  31 WGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAPVIFETERAQMEELHKSQ 97
Cdd:cd22884   1 AALKDIFPPSVRSAISSAASSTVSVAKKLLSFSGKAAWVLSTSALLLGVPLALEIEREQQLEEQEKQ 67
3a0801s05tom22 TIGR00986
mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase (MPT) ...
 5-119 3.97e-06

mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tom22 proteins. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273379  Cd Length: 145  Bit Score: 43.03  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657033     5 NEGKTSNDPQRENYDDEPDETASERFWGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAPVIFE 84
Cdd:TIGR00986  30 FTDVDSEDSVDSDFESLEEETFTDRIYALKDIVPPTTRGWIYHKYSTTTNFVKSTLSFAGRAAWAVSTSALLLGVPFAIS 109

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 24657033    85 -TERAQMEELHKSQQKQVllGPGSAMGPGGPSPSLP 119
Cdd:TIGR00986 110 fAEEQQLAEMEKEARMQE--LANDVLAAGGEGQAGT 143
Tom22 pfam04281
Mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase family, ...
 19-100 4.07e-06

Mitochondrial import receptor subunit Tom22; The mitochondrial protein translocase family, which is responsible for movement of nuclear encoded pre-proteins into mitochondria, is very complex with at least 19 components. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family represents the Tom22 proteins. The N terminal region of Tom22 has been shown to have chaperone-like activity, and the C terminal region faces the intermembrane face.


Pssm-ID: 427836  Cd Length: 138  Bit Score: 42.96  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657033    19 DDEPDETASERFWGLTEMFPEPVRNAVGAVSSATVKSVKGFYSFSCNASWIFFTSAVILFAP--VIFETErAQMEELHKS 96
Cdd:pfam04281  48 FDPENETLYDRIAALKDIIPPTTRGSISSKFSTTTSFVKSGFSFGGKLLWVVTTSALLLGVPlaLAILEE-QQLVEMEKE 126


                  ....
gi 24657033    97 QQKQ 100
Cdd:pfam04281 127 MRMQ 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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