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Conserved domains on  [gi|221330856|ref|NP_729034|]
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dynein heavy chain 64C, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1009-4315 0e+00

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 1161.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1009 TYRNLLTKLPEGkilENAYGAIEQKVSEVRNYVDEWLRYQSLWDLQADMLYGRLGEDVNLWIKCLNDIKQSRTTFDTSDT 1088
Cdd:COG5245   146 LSHELELIFRSG---EQWVGCMRKLYESVCSERDGFYEEKSFWSRFHMEMCHIREFCRSKAFRFACDVLRKSGKYVTVAT 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1089 RRAY-GPIIIDYAKVQAKVTLKYDSWhkealgkfGTLLGTEMTSFHSKVSKSRTDLEmQSIEAASTSDAVSFITYVQSL- 1166
Cdd:COG5245   223 LDSLlSSSKYSELGRRLHFYANMDFS--------GIYFPKSFSEFKDSVISATQAVS-RDIGRQSRMARRLILVQMDSLa 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1167 --KKDMIAWDKQVEVFREAQRILERQRFQFPNTWLHVDNIEGEWSAFNEIIKRkDTAIQTQVASLqAKIVAEDKAVETRT 1244
Cdd:COG5245   294 rlIVDRICEYVSIEWLGCCEELLTCSMESMSSLVNSFDGEESEAMSLESSLFY-EFRGGEHLAGF-YSAFGDIKRILLFT 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1245 VDFLNDWEKtKPTGGKIRPDDALQQLQIFESKYSRLKEERDNVVKAKEALelqesAVPNNSAERMNVALEELQDLRGVWS 1324
Cdd:COG5245   372 WSFKKLGTL-LPSLPGYSSGGMDYGEEYRSLLWELGSEVGDPDSGPVRKW-----MRKDLFDAKVRSGVSFGKQEEFVSD 445
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1325 ELSKVWTQIDETREKPWLSVQprkLRQQLEAMMAQLKELPaRLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKerHWK 1404
Cdd:COG5245   446 IFNITFERIHGMDPTTLEDDE---EDTPALAILLGQEEAG-RFVKLCKIMRMFSFFNSLEMFSRRTLANRMAIVK--YLS 519
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1405 QLTK----QLRVNWVLS-DLSLGQVWDVNLQKNEgivkdIILVAQGEMA--LEEFLKQVRESWQNYELDlinyqnkcRII 1477
Cdd:COG5245   520 SVVRtgplFLQRDFFGRmSELLMARDMFMEVDGV-----LRLFFGGEWSgiVQLSGIRRAKRCVERQID--------DEI 586
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1478 RGWddlfnkVKEHINSVAAMKLSPYYkvfeEEALTWEEKLNRINAlfdvwIDVqRRWVYLEGIFSGSADIKTLLPVETSR 1557
Cdd:COG5245   587 REW------CSSVLSDDFLEERAVRV----ERGADGARRLRASSG-----SPV-LRRLDEYLMMMSLEDLMPLIPHAVHR 650
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1558 FQSISSEFLGLMKKVTKSPKVMDVLNIPaVQRSLERLADLLGKIQKALGEYLERERTSFPRFyfVGDEDLLEIIGNSKNI 1637
Cdd:COG5245   651 KMSLVSGVRGIYKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVEELMDRVRELENR 727
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1638 ARLQKHFKKMFAGVAAILLNEenNVILGISSREGEEVHFMNPVSTVEHPKINEWLSLvekqmrfTLASLLAQAVQDIKQF 1717
Cdd:COG5245   728 VYSYRFFVKKIAKEEMKTVFS--SRIQKKEPFSLDSEAYVGFFRLYEKSIVIRGINR-------SMGRVLSQYLESVQEA 798
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1718 RDGKiDPQAYMEwcdKYQAQIVVLAAQiLWSEDVESALQQASennqSKPMQRVLGNVESTLNVLADSVLqeqpplrrRKL 1797
Cdd:COG5245   799 LEIE-DGSFFVS---RHRVRDGGLEKG-RGCDAWENCFDPPL----SEYFRILEKIFPSEEGYFFDEVL--------KRL 861
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1798 EHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYfdprqTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRC 1877
Cdd:COG5245   862 DPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-----QGLYKRFIKVRSSYRSAEMFAKNTIPFFVFEHSMDTSQ 936
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1878 YLTMTQALESRLggSPFgpAGTGKTESVKALGNQLGRFVlvfncdETFDFQAmgRIFVGLCQVGAWGcFDEFNRLEERML 1957
Cdd:COG5245   937 HQKLFEAVCDEV--CRF--VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESALLDEISR 1003
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1958 sACSQQIQTIQEALKYemdsNKESITveLVGKQVRVSPDMAIFITMNPgyagRSNLPDNLKKLFRSLAMTTPDRQlIAEV 2037
Cdd:COG5245  1004 -TILVDEYLNSDEFRM----LEELNS--AVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPFGA-IKSR 1071
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2038 MlfsqgfrsaEKLACKIVPFFKLCDEQLSNQSHYDFglRALKSVLisagnvkrdrimKIKEQMKQRGDENIDEASVAENL 2117
Cdd:COG5245  1072 R---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL------------KAKHRMLEEKTEYLNKILSITGL 1128
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2118 PeqeiliqsvcetmvpklvaedipllfsLLSDVFpnvgytRAEMKGLKEEIRKVCQEDYLVCGEGDEQGAAW-MEKVLQL 2196
Cdd:COG5245  1129 P---------------------------LISDTL------RERIDTLDAEWDSFCRISESLKKYESQQVSGLdVAQFVSF 1175
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2197 YQISNLNHGLMMVGPSGSGKSTAWKTLLKalerFEGVEGVAHVIDPkaiskealygVLDPnTREWTdGLFTHILRkiiDN 2276
Cdd:COG5245  1176 LRSVDTGAFHAEYFRVFLCKIKHYTDACD----YLWHVKSPYVKKK----------YFDA-DMELR-QFFLMFNR---ED 1236
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2277 VRGEI-NKRQWIIFDgdvdpEWVENLNSVLDDNKLLTLPNGERlslppnvRVMFEVQDlkfATLATVSRCGMVWFSEDVL 2355
Cdd:COG5245  1237 MEARLaDSKMEYEVE-----RYVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRL 1301
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2356 STEMIFENYLSRLRsipledgdedfvgviKPAKDKEEEVSPSLQVQRDIALLLLPFFSAdgivvrTLEYAMDQEHIMD-- 2433
Cdd:COG5245  1302 STKGVFLDELGDTK---------------RYLDECLDFFSCFEEVQKEIDELSMVFCAD------ALRFSADLYHIVKer 1360
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2434 -----FTRLRALSSLFSMLNQAARNVltfnaqhpdfpcSADQLEHYIPKALVYSVLWSFAGDAKLKVRIDLGDFVRSVTT 2508
Cdd:COG5245  1361 rfsgvLAGSDASESLGGKSIELAAIL------------EHKDLIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLI 1428
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2509 VPLPGaagapIIDYE------VNMSGDWVPWSnKVPVIEVETHKVASP-DIVVPTLDTVRHESLLYTWLAEHKPLVLCGP 2581
Cdd:COG5245  1429 KDLNE-----RSDYEemlimmFNISAVITNNG-SIAGFELRGERVMLRkEVVIPTSDTGFVDSFSNEALNTLRSYIYCGP 1502
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2582 PGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQIGKWLVLFCDEINLPDMDSYGT 2661
Cdd:COG5245  1503 PGSGKEMLMCPSLRSELITEVKYFNFSTCTMTPSKLSVLERETEYYPNTGVVRLYPKPVVKDLVLFCDEINLPYGFEYYP 1582
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2662 QRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPGRKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAML 2741
Cdd:COG5245  1583 PTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSY 1662
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2742 RLMPALRGYAEPLTNAMVEFYLASQDRFTQDMQPHYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDR 2821
Cdd:COG5245  1663 LCFDEFNRLSEETMSASVELYLSSKDKTKFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIIDWYCEAIREKIDR 1742
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2822 LVDDSERRWTNENIDLVGQKHFPGINQEEALQRPILYSNWLSKDYMPVNREELREYVHARLKVFYEEELDVPLVLFDEVL 2901
Cdd:COG5245  1743 LVQQKESSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFGMACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDAL 1822
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2902 DHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDE 2981
Cdd:COG5245  1823 LHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFE 1902
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2982 SNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLK 3061
Cdd:COG5245  1903 SIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEKDTEATLTRVFLVYMEENLPVVFSACCSQDTSV 1982
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3062 DRAATSPALFNRCVLNWFGDWSDSALFQVGKEFTTrvdLEKPNWHAPDFFPSVCPLVPANpTHRDAVINSCVYvhqtlHQ 3141
Cdd:COG5245  1983 LAGIRSPALKNRCFIDFKKLWDTEEMSQYANSVET---LSRDGGRVFFINGELGVGKGAL-ISEVFGDDAVVI-----EG 2053
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3142 ANARLAKRGGrTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAA 3221
Cdd:COG5245  2054 RGFEISMIEG-SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNA 2132
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3222 NAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAV 3301
Cdd:COG5245  2133 DDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGD 2212
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3302 VKLALESVCELLNESATDWKAIRGILVKDSFISSIVNLETDKITD-DVREKMKSKYLSNPDYNFEKVNRASMACGPMVKW 3380
Cdd:COG5245  2213 LCIEMEDVCDLLGFEAKIWFGEQQSLRRDDFIRIIGKYPDEIEFDlEARRFREARECSDPSFTGSILNRASKACGPLKRW 2292
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3381 AIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRS 3460
Cdd:COG5245  2293 LVRECNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRS 2372
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3461 IALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTTwSQHLQAASIQYRADIART--EYL 3538
Cdd:COG5245  2373 IFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGM-SFIRISKEFRDKEIRRRQfiTEG 2451
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3539 SNPDERLRWQANalpTDDLCTENA-IMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNP 3617
Cdd:COG5245  2452 VQKIEDFKEEAC---STDYGLENSrIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSD 2528
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3618 LLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQC 3697
Cdd:COG5245  2529 KIIGDAEALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEI 2608
                        2730      2740      2750      2760      2770      2780      2790      2800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3698 LNQVLKAERPDIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDETDKVIA 3777
Cdd:COG5245  2609 PDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIED 2688
                        2810      2820      2830      2840      2850      2860      2870      2880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3778 EIETVSQQYlPLSVACS-NIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLyNNPKLEGRTdhserLGIVTRDLFQVCYERV 3856
Cdd:COG5245  2689 RIDALKSEY-NASVKRLeSIRVEIAMFDEKALMYNKSICELSSEFEKWR-RMKSKYLCA-----IRYMLMSSEWILDHED 2761
                        2890      2900      2910      2920      2930      2940      2950      2960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3857 ARGMIHIDRLTFALLM-----CKIHLKGTSESNLDAEFNFFlrsregllanptpveGLSAEQIESVNRLALRLpifrkll 3931
Cdd:COG5245  2762 RSGFIHRLDVSFLLRTkrfvsTLLEDKNYRQVLSSCSLYGN---------------DVISHSCDRFDRDVYRA------- 2819
                        2970      2980      2990      3000      3010      3020      3030      3040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3932 ekvrsipelgawlqqsspeqvvpqlwdeSKALSPIASSVHQLLLIQAFRPDRviaaaHNVVNTVLGEDF-MPNAEQELDF 4010
Cdd:COG5245  2820 ----------------------------LKHQMDNRTHSTILTSNSKTNPYK-----EYTYNDSWAEAFeVEDSGDLYKF 2866
                        3050      3060      3070      3080      3090      3100      3110      3120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4011 TSVVDKQLNCNTPALlcsvpgfdasgrvddLAAEQNKQISSI--AIGSAEGFNQAERAINMACKTGRWVLLKNVHLAPQW 4088
Cdd:COG5245  2867 EEGLLELIVGHAPLI---------------YAHKKSLENERNvdRLGSKENEVYAVLNSLFSRKEKSWFEVYNISLSFGW 2931
                        3130      3140      3150      3160      3170      3180      3190      3200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4089 LVQLEKKM----HSLQPHSGFRLFLT-MEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFSTVPAarMMK-TPSERARL 4162
Cdd:COG5245  2932 FKRYVEDVvypiKASRVCGKVKNMWTsMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDRY--PFDyTLVIACDD 3009
                        3210      3220      3230      3240      3250      3260      3270      3280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4163 YFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDtwiDTTAMGRTNlppeKVPWDALVTLLSQSIYGGKIDND 4242
Cdd:COG5245  3010 AFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLK---NILFLNHLN----ARKWGNNRDLIFTIVYGKKHSLM 3082
                        3290      3300      3310      3320      3330      3340      3350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330856 4243 FDQRLLTSFLKKLFTArsfEADFALVANVDGASGGLRHITMPDGTRRDHFLKwIENLTDRQTPSWLGLPNNAE 4315
Cdd:COG5245  3083 EDSKVVDKYCRGYGAH---ETSSQILASVPGGDPELVKFHMEEMCRSSAFGV-IGQLPDLALCAWLMGPCDSE 3151
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
242-826 1.38e-133

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


:

Pssm-ID: 462457  Cd Length: 560  Bit Score: 432.39  E-value: 1.38e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   242 LNLLQNGVNRWIAEIKKVTKLNRDPGSGTALQEISFWLNLERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTG 321
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDSQGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKALDTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   322 LKQALATVADYNPLMKDF--PINDLLSATELEKIRPAVQQIFAHLRKV-RNTKY--PIQRCLKLIEAISRDLSQQLLKVL 396
Cdd:pfam08385   81 LTDALNEAKDNVKYLKTLerPFEDLEELTDPPEIIEAIPPLMNTIRLIwSISRYynTSERMTVLLEKISNQLIEQCKKYL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   397 GTRRLMHIPFDEFERVMNQCFEIFSCWDDEYDKLQGLLRDIVKKKRdehlkmvWRVSPAHK-----KLQTRMEHMRKFRR 471
Cdd:pfam08385  161 SPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERP-------WDFSERYIfgrfdAFLERLEKILELFE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   472 QHEQLRTviLRVLRPTKpavgddGNVVETKQpysldaadANAIEEVNLAYENVKEV--DCLDITKEGseaWEAAVKRYEE 549
Cdd:pfam08385  234 TIEQFSK--LEKIGGTK------GPELEGVI--------EEILEEFQEAYKVFKSKtyDILDVSNEG---FDDDYEEFKE 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   550 KIDRVETRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIEALHEKFKVQypqsKSCRL 629
Cdd:pfam08385  295 RIKDLERRLQAFIDQAFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQ----KYNPS 370
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   630 SSVRDLPPVAGSIIWARQIDNQLTMYLKRVEDVLGKGweTHIEGQKLKADGDSFRAKLS--ISDVFHEWARKVQERNFGS 707
Cdd:pfam08385  371 PIAKNMPPVAGAIIWARQLFRRIQEPMKRFKEELGLL--KHAEGKKVIKKYNELAKKLDeyERLIYEAWLKEVEEASEGN 448
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   708 TGR-IFTIESTRSRigrgnvlRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTL 786
Cdd:pfam08385  449 LKRpLLVRHPETGK-------LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIR 521
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 221330856   787 EKIedRASIVPLVAGLRKDVLNLVSEGIGLI-WESYKLDPY 826
Cdd:pfam08385  522 STL--LPVERPLLAPHLKDIDEKLEPGLTTLtWNSLGIDEY 560
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4320-4633 2.12e-58

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 205.55  E-value: 2.12e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4320 TTRGTDLVSKLLKMQQLEDddelaysvedqseqsavGRGEDGRPSWMKTLHNSATAWLELLPKNL---QVLKRTVENIKD 4396
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSD-----------------SGGGGGGSSREEIVLELAKDILEKLPEPFdieEAEEKYPVGYED 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4397 PLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSNRVQ 4476
Cdd:pfam18199   64 PLNTVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLK 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4477 QLQKVSqlvsqagakELQGFP--VWLGGLLNPEAYITATRQCVAQANSWSLEELALDVTITDAGLKNDQ----KDCCFgV 4550
Cdd:pfam18199  144 QLQDWL---------DDEGPPkvFWLSGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVteppEDGVY-V 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4551 TGLKLQGAQC-KNNELLLAST---IMMDLPVTILKWIKISSEPRISKL-TLPVYLNSTR--TELLFTVDLavAAGQESHS 4623
Cdd:pfam18199  214 HGLFLEGARWdRKNGCLVESEpkeLFSPLPVIHLKPVESDKKKLDENTyECPVYKTSERhsTNFVFSVDL--PTDKPPDH 291
                          330
                   ....*....|
gi 221330856  4624 FYERGVAVLT 4633
Cdd:pfam18199  292 WILRGVALLL 301
 
Name Accession Description Interval E-value
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1009-4315 0e+00

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 1161.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1009 TYRNLLTKLPEGkilENAYGAIEQKVSEVRNYVDEWLRYQSLWDLQADMLYGRLGEDVNLWIKCLNDIKQSRTTFDTSDT 1088
Cdd:COG5245   146 LSHELELIFRSG---EQWVGCMRKLYESVCSERDGFYEEKSFWSRFHMEMCHIREFCRSKAFRFACDVLRKSGKYVTVAT 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1089 RRAY-GPIIIDYAKVQAKVTLKYDSWhkealgkfGTLLGTEMTSFHSKVSKSRTDLEmQSIEAASTSDAVSFITYVQSL- 1166
Cdd:COG5245   223 LDSLlSSSKYSELGRRLHFYANMDFS--------GIYFPKSFSEFKDSVISATQAVS-RDIGRQSRMARRLILVQMDSLa 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1167 --KKDMIAWDKQVEVFREAQRILERQRFQFPNTWLHVDNIEGEWSAFNEIIKRkDTAIQTQVASLqAKIVAEDKAVETRT 1244
Cdd:COG5245   294 rlIVDRICEYVSIEWLGCCEELLTCSMESMSSLVNSFDGEESEAMSLESSLFY-EFRGGEHLAGF-YSAFGDIKRILLFT 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1245 VDFLNDWEKtKPTGGKIRPDDALQQLQIFESKYSRLKEERDNVVKAKEALelqesAVPNNSAERMNVALEELQDLRGVWS 1324
Cdd:COG5245   372 WSFKKLGTL-LPSLPGYSSGGMDYGEEYRSLLWELGSEVGDPDSGPVRKW-----MRKDLFDAKVRSGVSFGKQEEFVSD 445
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1325 ELSKVWTQIDETREKPWLSVQprkLRQQLEAMMAQLKELPaRLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKerHWK 1404
Cdd:COG5245   446 IFNITFERIHGMDPTTLEDDE---EDTPALAILLGQEEAG-RFVKLCKIMRMFSFFNSLEMFSRRTLANRMAIVK--YLS 519
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1405 QLTK----QLRVNWVLS-DLSLGQVWDVNLQKNEgivkdIILVAQGEMA--LEEFLKQVRESWQNYELDlinyqnkcRII 1477
Cdd:COG5245   520 SVVRtgplFLQRDFFGRmSELLMARDMFMEVDGV-----LRLFFGGEWSgiVQLSGIRRAKRCVERQID--------DEI 586
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1478 RGWddlfnkVKEHINSVAAMKLSPYYkvfeEEALTWEEKLNRINAlfdvwIDVqRRWVYLEGIFSGSADIKTLLPVETSR 1557
Cdd:COG5245   587 REW------CSSVLSDDFLEERAVRV----ERGADGARRLRASSG-----SPV-LRRLDEYLMMMSLEDLMPLIPHAVHR 650
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1558 FQSISSEFLGLMKKVTKSPKVMDVLNIPaVQRSLERLADLLGKIQKALGEYLERERTSFPRFyfVGDEDLLEIIGNSKNI 1637
Cdd:COG5245   651 KMSLVSGVRGIYKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVEELMDRVRELENR 727
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1638 ARLQKHFKKMFAGVAAILLNEenNVILGISSREGEEVHFMNPVSTVEHPKINEWLSLvekqmrfTLASLLAQAVQDIKQF 1717
Cdd:COG5245   728 VYSYRFFVKKIAKEEMKTVFS--SRIQKKEPFSLDSEAYVGFFRLYEKSIVIRGINR-------SMGRVLSQYLESVQEA 798
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1718 RDGKiDPQAYMEwcdKYQAQIVVLAAQiLWSEDVESALQQASennqSKPMQRVLGNVESTLNVLADSVLqeqpplrrRKL 1797
Cdd:COG5245   799 LEIE-DGSFFVS---RHRVRDGGLEKG-RGCDAWENCFDPPL----SEYFRILEKIFPSEEGYFFDEVL--------KRL 861
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1798 EHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYfdprqTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRC 1877
Cdd:COG5245   862 DPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-----QGLYKRFIKVRSSYRSAEMFAKNTIPFFVFEHSMDTSQ 936
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1878 YLTMTQALESRLggSPFgpAGTGKTESVKALGNQLGRFVlvfncdETFDFQAmgRIFVGLCQVGAWGcFDEFNRLEERML 1957
Cdd:COG5245   937 HQKLFEAVCDEV--CRF--VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESALLDEISR 1003
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1958 sACSQQIQTIQEALKYemdsNKESITveLVGKQVRVSPDMAIFITMNPgyagRSNLPDNLKKLFRSLAMTTPDRQlIAEV 2037
Cdd:COG5245  1004 -TILVDEYLNSDEFRM----LEELNS--AVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPFGA-IKSR 1071
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2038 MlfsqgfrsaEKLACKIVPFFKLCDEQLSNQSHYDFglRALKSVLisagnvkrdrimKIKEQMKQRGDENIDEASVAENL 2117
Cdd:COG5245  1072 R---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL------------KAKHRMLEEKTEYLNKILSITGL 1128
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2118 PeqeiliqsvcetmvpklvaedipllfsLLSDVFpnvgytRAEMKGLKEEIRKVCQEDYLVCGEGDEQGAAW-MEKVLQL 2196
Cdd:COG5245  1129 P---------------------------LISDTL------RERIDTLDAEWDSFCRISESLKKYESQQVSGLdVAQFVSF 1175
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2197 YQISNLNHGLMMVGPSGSGKSTAWKTLLKalerFEGVEGVAHVIDPkaiskealygVLDPnTREWTdGLFTHILRkiiDN 2276
Cdd:COG5245  1176 LRSVDTGAFHAEYFRVFLCKIKHYTDACD----YLWHVKSPYVKKK----------YFDA-DMELR-QFFLMFNR---ED 1236
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2277 VRGEI-NKRQWIIFDgdvdpEWVENLNSVLDDNKLLTLPNGERlslppnvRVMFEVQDlkfATLATVSRCGMVWFSEDVL 2355
Cdd:COG5245  1237 MEARLaDSKMEYEVE-----RYVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRL 1301
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2356 STEMIFENYLSRLRsipledgdedfvgviKPAKDKEEEVSPSLQVQRDIALLLLPFFSAdgivvrTLEYAMDQEHIMD-- 2433
Cdd:COG5245  1302 STKGVFLDELGDTK---------------RYLDECLDFFSCFEEVQKEIDELSMVFCAD------ALRFSADLYHIVKer 1360
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2434 -----FTRLRALSSLFSMLNQAARNVltfnaqhpdfpcSADQLEHYIPKALVYSVLWSFAGDAKLKVRIDLGDFVRSVTT 2508
Cdd:COG5245  1361 rfsgvLAGSDASESLGGKSIELAAIL------------EHKDLIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLI 1428
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2509 VPLPGaagapIIDYE------VNMSGDWVPWSnKVPVIEVETHKVASP-DIVVPTLDTVRHESLLYTWLAEHKPLVLCGP 2581
Cdd:COG5245  1429 KDLNE-----RSDYEemlimmFNISAVITNNG-SIAGFELRGERVMLRkEVVIPTSDTGFVDSFSNEALNTLRSYIYCGP 1502
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2582 PGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQIGKWLVLFCDEINLPDMDSYGT 2661
Cdd:COG5245  1503 PGSGKEMLMCPSLRSELITEVKYFNFSTCTMTPSKLSVLERETEYYPNTGVVRLYPKPVVKDLVLFCDEINLPYGFEYYP 1582
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2662 QRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPGRKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAML 2741
Cdd:COG5245  1583 PTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSY 1662
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2742 RLMPALRGYAEPLTNAMVEFYLASQDRFTQDMQPHYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDR 2821
Cdd:COG5245  1663 LCFDEFNRLSEETMSASVELYLSSKDKTKFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIIDWYCEAIREKIDR 1742
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2822 LVDDSERRWTNENIDLVGQKHFPGINQEEALQRPILYSNWLSKDYMPVNREELREYVHARLKVFYEEELDVPLVLFDEVL 2901
Cdd:COG5245  1743 LVQQKESSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFGMACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDAL 1822
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2902 DHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDE 2981
Cdd:COG5245  1823 LHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFE 1902
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2982 SNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLK 3061
Cdd:COG5245  1903 SIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEKDTEATLTRVFLVYMEENLPVVFSACCSQDTSV 1982
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3062 DRAATSPALFNRCVLNWFGDWSDSALFQVGKEFTTrvdLEKPNWHAPDFFPSVCPLVPANpTHRDAVINSCVYvhqtlHQ 3141
Cdd:COG5245  1983 LAGIRSPALKNRCFIDFKKLWDTEEMSQYANSVET---LSRDGGRVFFINGELGVGKGAL-ISEVFGDDAVVI-----EG 2053
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3142 ANARLAKRGGrTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAA 3221
Cdd:COG5245  2054 RGFEISMIEG-SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNA 2132
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3222 NAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAV 3301
Cdd:COG5245  2133 DDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGD 2212
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3302 VKLALESVCELLNESATDWKAIRGILVKDSFISSIVNLETDKITD-DVREKMKSKYLSNPDYNFEKVNRASMACGPMVKW 3380
Cdd:COG5245  2213 LCIEMEDVCDLLGFEAKIWFGEQQSLRRDDFIRIIGKYPDEIEFDlEARRFREARECSDPSFTGSILNRASKACGPLKRW 2292
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3381 AIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRS 3460
Cdd:COG5245  2293 LVRECNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRS 2372
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3461 IALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTTwSQHLQAASIQYRADIART--EYL 3538
Cdd:COG5245  2373 IFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGM-SFIRISKEFRDKEIRRRQfiTEG 2451
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3539 SNPDERLRWQANalpTDDLCTENA-IMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNP 3617
Cdd:COG5245  2452 VQKIEDFKEEAC---STDYGLENSrIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSD 2528
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3618 LLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQC 3697
Cdd:COG5245  2529 KIIGDAEALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEI 2608
                        2730      2740      2750      2760      2770      2780      2790      2800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3698 LNQVLKAERPDIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDETDKVIA 3777
Cdd:COG5245  2609 PDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIED 2688
                        2810      2820      2830      2840      2850      2860      2870      2880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3778 EIETVSQQYlPLSVACS-NIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLyNNPKLEGRTdhserLGIVTRDLFQVCYERV 3856
Cdd:COG5245  2689 RIDALKSEY-NASVKRLeSIRVEIAMFDEKALMYNKSICELSSEFEKWR-RMKSKYLCA-----IRYMLMSSEWILDHED 2761
                        2890      2900      2910      2920      2930      2940      2950      2960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3857 ARGMIHIDRLTFALLM-----CKIHLKGTSESNLDAEFNFFlrsregllanptpveGLSAEQIESVNRLALRLpifrkll 3931
Cdd:COG5245  2762 RSGFIHRLDVSFLLRTkrfvsTLLEDKNYRQVLSSCSLYGN---------------DVISHSCDRFDRDVYRA------- 2819
                        2970      2980      2990      3000      3010      3020      3030      3040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3932 ekvrsipelgawlqqsspeqvvpqlwdeSKALSPIASSVHQLLLIQAFRPDRviaaaHNVVNTVLGEDF-MPNAEQELDF 4010
Cdd:COG5245  2820 ----------------------------LKHQMDNRTHSTILTSNSKTNPYK-----EYTYNDSWAEAFeVEDSGDLYKF 2866
                        3050      3060      3070      3080      3090      3100      3110      3120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4011 TSVVDKQLNCNTPALlcsvpgfdasgrvddLAAEQNKQISSI--AIGSAEGFNQAERAINMACKTGRWVLLKNVHLAPQW 4088
Cdd:COG5245  2867 EEGLLELIVGHAPLI---------------YAHKKSLENERNvdRLGSKENEVYAVLNSLFSRKEKSWFEVYNISLSFGW 2931
                        3130      3140      3150      3160      3170      3180      3190      3200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4089 LVQLEKKM----HSLQPHSGFRLFLT-MEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFSTVPAarMMK-TPSERARL 4162
Cdd:COG5245  2932 FKRYVEDVvypiKASRVCGKVKNMWTsMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDRY--PFDyTLVIACDD 3009
                        3210      3220      3230      3240      3250      3260      3270      3280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4163 YFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDtwiDTTAMGRTNlppeKVPWDALVTLLSQSIYGGKIDND 4242
Cdd:COG5245  3010 AFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLK---NILFLNHLN----ARKWGNNRDLIFTIVYGKKHSLM 3082
                        3290      3300      3310      3320      3330      3340      3350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330856 4243 FDQRLLTSFLKKLFTArsfEADFALVANVDGASGGLRHITMPDGTRRDHFLKwIENLTDRQTPSWLGLPNNAE 4315
Cdd:COG5245  3083 EDSKVVDKYCRGYGAH---ETSSQILASVPGGDPELVKFHMEEMCRSSAFGV-IGQLPDLALCAWLMGPCDSE 3151
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1857-2217 3.13e-168

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 522.04  E-value: 3.13e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1857 YGFEYLGVQDRLVQTPLTDRCYLTMTQALESRLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVG 1936
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1937 LCQVGAWGCFDEFNRLEERMLSACSQQIQTIQEALKyemdSNKESITVElvGKQVRVSPDMAIFITMNPGYAGRSNLPDN 2016
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALA----ANLKTFVFE--GSEIKLNPSCGIFITMNPGYAGRTELPDN 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2017 LKKLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLISAGNVKRDRimki 2096
Cdd:pfam12774  155 LKALFRPVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN---- 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2097 keqmkqrgdenideasvaENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVGYTRAEMKGLKEEIRKVCQEDY 2176
Cdd:pfam12774  231 ------------------PNLNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELG 292
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 221330856  2177 LVCGEgdeqgaAWMEKVLQLYQISNLNHGLMMVGPSGSGKS 2217
Cdd:pfam12774  293 LQPHD------AFILKVIQLYETMLVRHGVMLVGPTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
242-826 1.38e-133

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 432.39  E-value: 1.38e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   242 LNLLQNGVNRWIAEIKKVTKLNRDPGSGTALQEISFWLNLERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTG 321
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDSQGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKALDTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   322 LKQALATVADYNPLMKDF--PINDLLSATELEKIRPAVQQIFAHLRKV-RNTKY--PIQRCLKLIEAISRDLSQQLLKVL 396
Cdd:pfam08385   81 LTDALNEAKDNVKYLKTLerPFEDLEELTDPPEIIEAIPPLMNTIRLIwSISRYynTSERMTVLLEKISNQLIEQCKKYL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   397 GTRRLMHIPFDEFERVMNQCFEIFSCWDDEYDKLQGLLRDIVKKKRdehlkmvWRVSPAHK-----KLQTRMEHMRKFRR 471
Cdd:pfam08385  161 SPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERP-------WDFSERYIfgrfdAFLERLEKILELFE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   472 QHEQLRTviLRVLRPTKpavgddGNVVETKQpysldaadANAIEEVNLAYENVKEV--DCLDITKEGseaWEAAVKRYEE 549
Cdd:pfam08385  234 TIEQFSK--LEKIGGTK------GPELEGVI--------EEILEEFQEAYKVFKSKtyDILDVSNEG---FDDDYEEFKE 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   550 KIDRVETRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIEALHEKFKVQypqsKSCRL 629
Cdd:pfam08385  295 RIKDLERRLQAFIDQAFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQ----KYNPS 370
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   630 SSVRDLPPVAGSIIWARQIDNQLTMYLKRVEDVLGKGweTHIEGQKLKADGDSFRAKLS--ISDVFHEWARKVQERNFGS 707
Cdd:pfam08385  371 PIAKNMPPVAGAIIWARQLFRRIQEPMKRFKEELGLL--KHAEGKKVIKKYNELAKKLDeyERLIYEAWLKEVEEASEGN 448
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   708 TGR-IFTIESTRSRigrgnvlRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTL 786
Cdd:pfam08385  449 LKRpLLVRHPETGK-------LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIR 521
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 221330856   787 EKIedRASIVPLVAGLRKDVLNLVSEGIGLI-WESYKLDPY 826
Cdd:pfam08385  522 STL--LPVERPLLAPHLKDIDEKLEPGLTTLtWNSLGIDEY 560
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4320-4633 2.12e-58

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 205.55  E-value: 2.12e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4320 TTRGTDLVSKLLKMQQLEDddelaysvedqseqsavGRGEDGRPSWMKTLHNSATAWLELLPKNL---QVLKRTVENIKD 4396
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSD-----------------SGGGGGGSSREEIVLELAKDILEKLPEPFdieEAEEKYPVGYED 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4397 PLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSNRVQ 4476
Cdd:pfam18199   64 PLNTVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLK 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4477 QLQKVSqlvsqagakELQGFP--VWLGGLLNPEAYITATRQCVAQANSWSLEELALDVTITDAGLKNDQ----KDCCFgV 4550
Cdd:pfam18199  144 QLQDWL---------DDEGPPkvFWLSGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVteppEDGVY-V 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4551 TGLKLQGAQC-KNNELLLAST---IMMDLPVTILKWIKISSEPRISKL-TLPVYLNSTR--TELLFTVDLavAAGQESHS 4623
Cdd:pfam18199  214 HGLFLEGARWdRKNGCLVESEpkeLFSPLPVIHLKPVESDKKKLDENTyECPVYKTSERhsTNFVFSVDL--PTDKPPDH 291
                          330
                   ....*....|
gi 221330856  4624 FYERGVAVLT 4633
Cdd:pfam18199  292 WILRGVALLL 301
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2555-2718 9.88e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.93  E-value: 9.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2555 PTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMTLFSALRAL--PDMEVVGLNFSSATTPELLLKTFDHYCEYRKTpng 2632
Cdd:cd00009     1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrPGAPFLYLNASDLLEGLVVAELFGHFLVRLLF--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2633 vvlSPVQIGKWLVLFCDEIN-LPDMDSYGTQRVISFLRQLVEhkgfyrasdqawvSLERIQFVGACNPPTDPG-RKPLSH 2710
Cdd:cd00009    78 ---ELAEKAKPGVLFIDEIDsLSRGAQNALLRVLETLNDLRI-------------DRENVRVIGATNRPLLGDlDRALYD 141

                  ....*...
gi 221330856 2711 RFLRHVPI 2718
Cdd:cd00009   142 RLDIRIVI 149
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
2573-2718 1.81e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.83  E-value: 1.81e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   2573 HKPLVLCGPPGSGKTMTLFSALRALPDMevvGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQI----------GK 2642
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPP---GGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRlrlalalarkLK 78
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330856   2643 WLVLFCDEI-NLPDMDSYGTQRVISFLRQLVEHKgfyrasdqawvSLERIQFVGACNPPTDPGRKPLSHRFLRHVPI 2718
Cdd:smart00382   79 PDVLILDEItSLLDAEQEALLLLLEELRLLLLLK-----------SEKNLTVILTTNDEKDLGPALLRRRFDRRIVL 144
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3133-3490 6.30e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 6.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3133 VYVHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVklyNEKRSDLEEQQLHLNvglNKIAETVEQVEEMQKSLAVKKQ 3212
Cdd:TIGR02168  625 VLVVDDLDNALELAKKLRPGYRIVTLDGDLVRPGGVI---TGGSAKTNSSILERR---REIEELEEKIEELEEKIAELEK 698
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3213 ELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLAdqtvKIEEKRKYVMADLAQVEPAVIDAQAavssiKKKHLAEV 3292
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEELSRQISALRKDLA----RLEAEVEQLEERIAQLSKELTELEA-----EIEELEER 769
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3293 RSMANPPAVVKLA-LESVCELLNESATDWKAIRGILVKdsfISSIVNLETDKITdDVREKMkskylsnpdynfEKVNRAS 3371
Cdd:TIGR02168  770 LEEAEEELAEAEAeIEELEAQIEQLKEELKALREALDE---LRAELTLLNEEAA-NLRERL------------ESLERRI 833
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3372 MACGPMVKWAIAQIEyaDMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLIsqaqaikTDLE 3451
Cdd:TIGR02168  834 AATERRLEDLEEQIE--ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELS-------EELR 904
                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 221330856  3452 NVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIG 3490
Cdd:TIGR02168  905 ELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943
PRK01156 PRK01156
chromosome segregation protein; Provisional
3163-3488 5.69e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.43  E-value: 5.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3163 DFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQElqakneaanaklkqmfqdQQEAEKKKIQS 3242
Cdd:PRK01156  465 EKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEIN------------------KSINEYNKIES 526
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3243 QEIQIrladqtvkieekrKYVMADLAQVEPAVIDAQAAVSSIKKKHLaevrsmanppavvklalesvcELLNESATDWka 3322
Cdd:PRK01156  527 ARADL-------------EDIKIKINELKDKHDKYEEIKNRYKSLKL---------------------EDLDSKRTSW-- 570
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3323 irgiLVKDSFISSIVNLETDKITDDVREKMKS--KYLSNPDYNFEKVNrasmacgpmvkwaiaqiEYAD-MLKRVEplrE 3399
Cdd:PRK01156  571 ----LNALAVISLIDIETNRSRSNEIKKQLNDleSRLQEIEIGFPDDK-----------------SYIDkSIREIE---N 626
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3400 ELRSLEEQadVNLASAKetKDLVEQLERSIAAYKEEYA----------QLISQAQAIKTDLENVQAKVDRSiallkslNI 3469
Cdd:PRK01156  627 EANNLNNK--YNEIQEN--KILIEKLRGKIDNYKKQIAeidsiipdlkEITSRINDIEDNLKKSRKALDDA-------KA 695
                         330
                  ....*....|....*....
gi 221330856 3470 ERERWESTSETFKSQMSTI 3488
Cdd:PRK01156  696 NRARLESTIEILRTRINEL 714
 
Name Accession Description Interval E-value
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1009-4315 0e+00

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 1161.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1009 TYRNLLTKLPEGkilENAYGAIEQKVSEVRNYVDEWLRYQSLWDLQADMLYGRLGEDVNLWIKCLNDIKQSRTTFDTSDT 1088
Cdd:COG5245   146 LSHELELIFRSG---EQWVGCMRKLYESVCSERDGFYEEKSFWSRFHMEMCHIREFCRSKAFRFACDVLRKSGKYVTVAT 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1089 RRAY-GPIIIDYAKVQAKVTLKYDSWhkealgkfGTLLGTEMTSFHSKVSKSRTDLEmQSIEAASTSDAVSFITYVQSL- 1166
Cdd:COG5245   223 LDSLlSSSKYSELGRRLHFYANMDFS--------GIYFPKSFSEFKDSVISATQAVS-RDIGRQSRMARRLILVQMDSLa 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1167 --KKDMIAWDKQVEVFREAQRILERQRFQFPNTWLHVDNIEGEWSAFNEIIKRkDTAIQTQVASLqAKIVAEDKAVETRT 1244
Cdd:COG5245   294 rlIVDRICEYVSIEWLGCCEELLTCSMESMSSLVNSFDGEESEAMSLESSLFY-EFRGGEHLAGF-YSAFGDIKRILLFT 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1245 VDFLNDWEKtKPTGGKIRPDDALQQLQIFESKYSRLKEERDNVVKAKEALelqesAVPNNSAERMNVALEELQDLRGVWS 1324
Cdd:COG5245   372 WSFKKLGTL-LPSLPGYSSGGMDYGEEYRSLLWELGSEVGDPDSGPVRKW-----MRKDLFDAKVRSGVSFGKQEEFVSD 445
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1325 ELSKVWTQIDETREKPWLSVQprkLRQQLEAMMAQLKELPaRLRMYESYEYVKKLIQSYIKVNMLIVELKSDALKerHWK 1404
Cdd:COG5245   446 IFNITFERIHGMDPTTLEDDE---EDTPALAILLGQEEAG-RFVKLCKIMRMFSFFNSLEMFSRRTLANRMAIVK--YLS 519
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1405 QLTK----QLRVNWVLS-DLSLGQVWDVNLQKNEgivkdIILVAQGEMA--LEEFLKQVRESWQNYELDlinyqnkcRII 1477
Cdd:COG5245   520 SVVRtgplFLQRDFFGRmSELLMARDMFMEVDGV-----LRLFFGGEWSgiVQLSGIRRAKRCVERQID--------DEI 586
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1478 RGWddlfnkVKEHINSVAAMKLSPYYkvfeEEALTWEEKLNRINAlfdvwIDVqRRWVYLEGIFSGSADIKTLLPVETSR 1557
Cdd:COG5245   587 REW------CSSVLSDDFLEERAVRV----ERGADGARRLRASSG-----SPV-LRRLDEYLMMMSLEDLMPLIPHAVHR 650
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1558 FQSISSEFLGLMKKVTKSPKVMDVLNIPaVQRSLERLADLLGKIQKALGEYLERERTSFPRFyfVGDEDLLEIIGNSKNI 1637
Cdd:COG5245   651 KMSLVSGVRGIYKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVEELMDRVRELENR 727
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1638 ARLQKHFKKMFAGVAAILLNEenNVILGISSREGEEVHFMNPVSTVEHPKINEWLSLvekqmrfTLASLLAQAVQDIKQF 1717
Cdd:COG5245   728 VYSYRFFVKKIAKEEMKTVFS--SRIQKKEPFSLDSEAYVGFFRLYEKSIVIRGINR-------SMGRVLSQYLESVQEA 798
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1718 RDGKiDPQAYMEwcdKYQAQIVVLAAQiLWSEDVESALQQASennqSKPMQRVLGNVESTLNVLADSVLqeqpplrrRKL 1797
Cdd:COG5245   799 LEIE-DGSFFVS---RHRVRDGGLEKG-RGCDAWENCFDPPL----SEYFRILEKIFPSEEGYFFDEVL--------KRL 861
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1798 EHLINEFVHKRTVTRRLLNNGVTSPKSFQWLCEMRFYfdprqTEVLQQLTIHMANARFFYGFEYLGVQDRLVQTPLTDRC 1877
Cdd:COG5245   862 DPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVSISELP-----QGLYKRFIKVRSSYRSAEMFAKNTIPFFVFEHSMDTSQ 936
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1878 YLTMTQALESRLggSPFgpAGTGKTESVKALGNQLGRFVlvfncdETFDFQAmgRIFVGLCQVGAWGcFDEFNRLEERML 1957
Cdd:COG5245   937 HQKLFEAVCDEV--CRF--VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESALLDEISR 1003
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 1958 sACSQQIQTIQEALKYemdsNKESITveLVGKQVRVSPDMAIFITMNPgyagRSNLPDNLKKLFRSLAMTTPDRQlIAEV 2037
Cdd:COG5245  1004 -TILVDEYLNSDEFRM----LEELNS--AVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPFGA-IKSR 1071
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2038 MlfsqgfrsaEKLACKIVPFFKLCDEQLSNQSHYDFglRALKSVLisagnvkrdrimKIKEQMKQRGDENIDEASVAENL 2117
Cdd:COG5245  1072 R---------ESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL------------KAKHRMLEEKTEYLNKILSITGL 1128
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2118 PeqeiliqsvcetmvpklvaedipllfsLLSDVFpnvgytRAEMKGLKEEIRKVCQEDYLVCGEGDEQGAAW-MEKVLQL 2196
Cdd:COG5245  1129 P---------------------------LISDTL------RERIDTLDAEWDSFCRISESLKKYESQQVSGLdVAQFVSF 1175
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2197 YQISNLNHGLMMVGPSGSGKSTAWKTLLKalerFEGVEGVAHVIDPkaiskealygVLDPnTREWTdGLFTHILRkiiDN 2276
Cdd:COG5245  1176 LRSVDTGAFHAEYFRVFLCKIKHYTDACD----YLWHVKSPYVKKK----------YFDA-DMELR-QFFLMFNR---ED 1236
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2277 VRGEI-NKRQWIIFDgdvdpEWVENLNSVLDDNKLLTLPNGERlslppnvRVMFEVQDlkfATLATVSRCGMVWFSEDVL 2355
Cdd:COG5245  1237 MEARLaDSKMEYEVE-----RYVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRL 1301
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2356 STEMIFENYLSRLRsipledgdedfvgviKPAKDKEEEVSPSLQVQRDIALLLLPFFSAdgivvrTLEYAMDQEHIMD-- 2433
Cdd:COG5245  1302 STKGVFLDELGDTK---------------RYLDECLDFFSCFEEVQKEIDELSMVFCAD------ALRFSADLYHIVKer 1360
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2434 -----FTRLRALSSLFSMLNQAARNVltfnaqhpdfpcSADQLEHYIPKALVYSVLWSFAGDAKLKVRIDLGDFVRSVTT 2508
Cdd:COG5245  1361 rfsgvLAGSDASESLGGKSIELAAIL------------EHKDLIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLI 1428
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2509 VPLPGaagapIIDYE------VNMSGDWVPWSnKVPVIEVETHKVASP-DIVVPTLDTVRHESLLYTWLAEHKPLVLCGP 2581
Cdd:COG5245  1429 KDLNE-----RSDYEemlimmFNISAVITNNG-SIAGFELRGERVMLRkEVVIPTSDTGFVDSFSNEALNTLRSYIYCGP 1502
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2582 PGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQIGKWLVLFCDEINLPDMDSYGT 2661
Cdd:COG5245  1503 PGSGKEMLMCPSLRSELITEVKYFNFSTCTMTPSKLSVLERETEYYPNTGVVRLYPKPVVKDLVLFCDEINLPYGFEYYP 1582
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2662 QRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTDPGRKPLSHRFLRHVPIIYVDYPGETSLKQIYGTFSRAML 2741
Cdd:COG5245  1583 PTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSY 1662
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2742 RLMPALRGYAEPLTNAMVEFYLASQDRFTQDMQPHYVYSPREMTRWVRGICEAIRPLDSLPVEGLVRLWAHEALRLFQDR 2821
Cdd:COG5245  1663 LCFDEFNRLSEETMSASVELYLSSKDKTKFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIIDWYCEAIREKIDR 1742
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2822 LVDDSERRWTNENIDLVGQKHFPGINQEEALQRPILYSNWLSKDYMPVNREELREYVHARLKVFYEEELDVPLVLFDEVL 2901
Cdd:COG5245  1743 LVQQKESSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFGMACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDAL 1822
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2902 DHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKDEKIAFILDE 2981
Cdd:COG5245  1823 LHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFE 1902
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2982 SNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDGLK 3061
Cdd:COG5245  1903 SIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEKDTEATLTRVFLVYMEENLPVVFSACCSQDTSV 1982
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3062 DRAATSPALFNRCVLNWFGDWSDSALFQVGKEFTTrvdLEKPNWHAPDFFPSVCPLVPANpTHRDAVINSCVYvhqtlHQ 3141
Cdd:COG5245  1983 LAGIRSPALKNRCFIDFKKLWDTEEMSQYANSVET---LSRDGGRVFFINGELGVGKGAL-ISEVFGDDAVVI-----EG 2053
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3142 ANARLAKRGGrTMAVTPRHYLDFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAA 3221
Cdd:COG5245  2054 RGFEISMIEG-SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNA 2132
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3222 NAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAV 3301
Cdd:COG5245  2133 DDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGD 2212
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3302 VKLALESVCELLNESATDWKAIRGILVKDSFISSIVNLETDKITD-DVREKMKSKYLSNPDYNFEKVNRASMACGPMVKW 3380
Cdd:COG5245  2213 LCIEMEDVCDLLGFEAKIWFGEQQSLRRDDFIRIIGKYPDEIEFDlEARRFREARECSDPSFTGSILNRASKACGPLKRW 2292
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3381 AIAQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRS 3460
Cdd:COG5245  2293 LVRECNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRS 2372
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3461 IALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAAFIAYGGYFDQHYRLNLFTTwSQHLQAASIQYRADIART--EYL 3538
Cdd:COG5245  2373 IFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGM-SFIRISKEFRDKEIRRRQfiTEG 2451
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3539 SNPDERLRWQANalpTDDLCTENA-IMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNP 3617
Cdd:COG5245  2452 VQKIEDFKEEAC---STDYGLENSrIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSD 2528
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3618 LLVQDVENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQC 3697
Cdd:COG5245  2529 KIIGDAEALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEI 2608
                        2730      2740      2750      2760      2770      2780      2790      2800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3698 LNQVLKAERPDIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDINQKVDETDKVIA 3777
Cdd:COG5245  2609 PDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIED 2688
                        2810      2820      2830      2840      2850      2860      2870      2880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3778 EIETVSQQYlPLSVACS-NIYFTMDSLNQVHFLYQYSLKMFLDIFSTVLyNNPKLEGRTdhserLGIVTRDLFQVCYERV 3856
Cdd:COG5245  2689 RIDALKSEY-NASVKRLeSIRVEIAMFDEKALMYNKSICELSSEFEKWR-RMKSKYLCA-----IRYMLMSSEWILDHED 2761
                        2890      2900      2910      2920      2930      2940      2950      2960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3857 ARGMIHIDRLTFALLM-----CKIHLKGTSESNLDAEFNFFlrsregllanptpveGLSAEQIESVNRLALRLpifrkll 3931
Cdd:COG5245  2762 RSGFIHRLDVSFLLRTkrfvsTLLEDKNYRQVLSSCSLYGN---------------DVISHSCDRFDRDVYRA------- 2819
                        2970      2980      2990      3000      3010      3020      3030      3040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3932 ekvrsipelgawlqqsspeqvvpqlwdeSKALSPIASSVHQLLLIQAFRPDRviaaaHNVVNTVLGEDF-MPNAEQELDF 4010
Cdd:COG5245  2820 ----------------------------LKHQMDNRTHSTILTSNSKTNPYK-----EYTYNDSWAEAFeVEDSGDLYKF 2866
                        3050      3060      3070      3080      3090      3100      3110      3120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4011 TSVVDKQLNCNTPALlcsvpgfdasgrvddLAAEQNKQISSI--AIGSAEGFNQAERAINMACKTGRWVLLKNVHLAPQW 4088
Cdd:COG5245  2867 EEGLLELIVGHAPLI---------------YAHKKSLENERNvdRLGSKENEVYAVLNSLFSRKEKSWFEVYNISLSFGW 2931
                        3130      3140      3150      3160      3170      3180      3190      3200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4089 LVQLEKKM----HSLQPHSGFRLFLT-MEINPKVPVNLLRAGRIFVFEPPPGIRANLLRTFSTVPAarMMK-TPSERARL 4162
Cdd:COG5245  2932 FKRYVEDVvypiKASRVCGKVKNMWTsMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDRY--PFDyTLVIACDD 3009
                        3210      3220      3230      3240      3250      3260      3270      3280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 4163 YFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDtwiDTTAMGRTNlppeKVPWDALVTLLSQSIYGGKIDND 4242
Cdd:COG5245  3010 AFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLK---NILFLNHLN----ARKWGNNRDLIFTIVYGKKHSLM 3082
                        3290      3300      3310      3320      3330      3340      3350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330856 4243 FDQRLLTSFLKKLFTArsfEADFALVANVDGASGGLRHITMPDGTRRDHFLKwIENLTDRQTPSWLGLPNNAE 4315
Cdd:COG5245  3083 EDSKVVDKYCRGYGAH---ETSSQILASVPGGDPELVKFHMEEMCRSSAFGV-IGQLPDLALCAWLMGPCDSE 3151
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1857-2217 3.13e-168

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 522.04  E-value: 3.13e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1857 YGFEYLGVQDRLVQTPLTDRCYLTMTQALESRLGGSPFGPAGTGKTESVKALGNQLGRFVLVFNCDETFDFQAMGRIFVG 1936
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1937 LCQVGAWGCFDEFNRLEERMLSACSQQIQTIQEALKyemdSNKESITVElvGKQVRVSPDMAIFITMNPGYAGRSNLPDN 2016
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALA----ANLKTFVFE--GSEIKLNPSCGIFITMNPGYAGRTELPDN 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2017 LKKLFRSLAMTTPDRQLIAEVMLFSQGFRSAEKLACKIVPFFKLCDEQLSNQSHYDFGLRALKSVLISAGNVKRDRimki 2096
Cdd:pfam12774  155 LKALFRPVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN---- 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2097 keqmkqrgdenideasvaENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPNVGYTRAEMKGLKEEIRKVCQEDY 2176
Cdd:pfam12774  231 ------------------PNLNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELG 292
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 221330856  2177 LVCGEgdeqgaAWMEKVLQLYQISNLNHGLMMVGPSGSGKS 2217
Cdd:pfam12774  293 LQPHD------AFILKVIQLYETMLVRHGVMLVGPTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1309-1710 1.03e-142

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 452.10  E-value: 1.03e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1309 MNVALEELQDLRGVWSELSKVWTQIDETREKPWLSVQPRKLRQQLEAMMAQLKELPARLRMYESYEYVKKLIQSYIKVNM 1388
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1389 LIVELKSDALKERHWKQLTKQLRVNW--VLSDLSLGQVWDVNLQKNEGIVKDIILVAQGEMALEEFLKQVRESWQNYELD 1466
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFdpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1467 LINYQN-KCRIIRGWDDLFNKVKEHINSVAAMKLSPYYKVFEEEALTWEEKLNRINALFDVWIDVQRRWVYLEGIFSGSa 1545
Cdd:pfam08393  161 LVPYKDtGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFSSE- 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1546 DIKTLLPVETSRFQSISSEFLGLMKKVTKSPKVMDVLNIPAVQRSLERLADLLGKIQKALGEYLERERTSFPRFYFVGDE 1625
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  1626 DLLEIIGNSKNIARLQKHFKKMFAGVAAILLNeENNVILGISSREGEEVHFMNPVSTVEhPKINEWLSLVEKQMRFTLAS 1705
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFD-ENKEITGMISKEGEVVPFSKPPVEAK-GNVEEWLNELEEEMRETLRD 397

                   ....*
gi 221330856  1706 LLAQA 1710
Cdd:pfam08393  398 LLKEA 402
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
242-826 1.38e-133

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 432.39  E-value: 1.38e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   242 LNLLQNGVNRWIAEIKKVTKLNRDPGSGTALQEISFWLNLERALYRIQEKRESPEVALTLDILKHGKRFHATVSFDTDTG 321
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDSQGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKALDTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   322 LKQALATVADYNPLMKDF--PINDLLSATELEKIRPAVQQIFAHLRKV-RNTKY--PIQRCLKLIEAISRDLSQQLLKVL 396
Cdd:pfam08385   81 LTDALNEAKDNVKYLKTLerPFEDLEELTDPPEIIEAIPPLMNTIRLIwSISRYynTSERMTVLLEKISNQLIEQCKKYL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   397 GTRRLMHIPFDEFERVMNQCFEIFSCWDDEYDKLQGLLRDIVKKKRdehlkmvWRVSPAHK-----KLQTRMEHMRKFRR 471
Cdd:pfam08385  161 SPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERP-------WDFSERYIfgrfdAFLERLEKILELFE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   472 QHEQLRTviLRVLRPTKpavgddGNVVETKQpysldaadANAIEEVNLAYENVKEV--DCLDITKEGseaWEAAVKRYEE 549
Cdd:pfam08385  234 TIEQFSK--LEKIGGTK------GPELEGVI--------EEILEEFQEAYKVFKSKtyDILDVSNEG---FDDDYEEFKE 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   550 KIDRVETRITAHLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIEALHEKFKVQypqsKSCRL 629
Cdd:pfam08385  295 RIKDLERRLQAFIDQAFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQ----KYNPS 370
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   630 SSVRDLPPVAGSIIWARQIDNQLTMYLKRVEDVLGKGweTHIEGQKLKADGDSFRAKLS--ISDVFHEWARKVQERNFGS 707
Cdd:pfam08385  371 PIAKNMPPVAGAIIWARQLFRRIQEPMKRFKEELGLL--KHAEGKKVIKKYNELAKKLDeyERLIYEAWLKEVEEASEGN 448
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   708 TGR-IFTIESTRSRigrgnvlRLRVNFLPEIITLAKEVRNIKNLGFRVPLTIVNKAHQANQIYPYAISLIESVRTYERTL 786
Cdd:pfam08385  449 LKRpLLVRHPETGK-------LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELLVRWYNKIR 521
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 221330856   787 EKIedRASIVPLVAGLRKDVLNLVSEGIGLI-WESYKLDPY 826
Cdd:pfam08385  522 STL--LPVERPLLAPHLKDIDEKLEPGLTTLtWNSLGIDEY 560
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3545-3765 1.16e-99

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 320.54  E-value: 1.16e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3545 LRWQANALPTDDLCTENAIMLKRFNRYPLIIDPSGQATTFLLNEYAGKKITKTSFLDDSFRKNLESALRFGNPLLVQDV- 3623
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVg 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3624 ENYDPILNPVLNRELRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDICSRVTFVNFTVTRSSLQSQCLNQVLK 3703
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221330856  3704 AERPDIDEKRSDLLKLQGEFRLRLRQLEKSLLQALNDAKGKILDDDSVITTLETLKKEAYDI 3765
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2893-3171 6.22e-68

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 231.34  E-value: 6.22e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2893 PLVLFDEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNKYTSEDFDEDLRCVLRRSGCKD 2972
Cdd:pfam12780    2 DLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIKG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2973 EKIAFILDESNVLDSGFLERMNTLLANGEVPGLFEGDEYTTLMTQCKEGAQREGLmLDSSDELYKWFTQQVMRNLHVVFT 3052
Cdd:pfam12780   82 KPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNI-EDSREAVYNYFVKRCRNNLHIVLC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3053 MNPSTDGLKDRAATSPALFNRCVLNWFGDWSDSALFQVGKEFTTRVdlekpnwhapdffpsvcpLVPANptHRDAVINSC 3132
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDI------------------EIPEE--LKSNVVKVF 220
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 221330856  3133 VYVHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVKL 3171
Cdd:pfam12780  221 VYVHSSVEDMSKKFYEELKRKNYVTPKSYLELLRLYKNL 259
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4320-4633 2.12e-58

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 205.55  E-value: 2.12e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4320 TTRGTDLVSKLLKMQQLEDddelaysvedqseqsavGRGEDGRPSWMKTLHNSATAWLELLPKNL---QVLKRTVENIKD 4396
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSD-----------------SGGGGGGSSREEIVLELAKDILEKLPEPFdieEAEEKYPVGYED 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4397 PLYRYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSNRVQ 4476
Cdd:pfam18199   64 PLNTVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLK 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4477 QLQKVSqlvsqagakELQGFP--VWLGGLLNPEAYITATRQCVAQANSWSLEELALDVTITDAGLKNDQ----KDCCFgV 4550
Cdd:pfam18199  144 QLQDWL---------DDEGPPkvFWLSGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVteppEDGVY-V 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4551 TGLKLQGAQC-KNNELLLAST---IMMDLPVTILKWIKISSEPRISKL-TLPVYLNSTR--TELLFTVDLavAAGQESHS 4623
Cdd:pfam18199  214 HGLFLEGARWdRKNGCLVESEpkeLFSPLPVIHLKPVESDKKKLDENTyECPVYKTSERhsTNFVFSVDL--PTDKPPDH 291
                          330
                   ....*....|
gi 221330856  4624 FYERGVAVLT 4633
Cdd:pfam18199  292 WILRGVALLL 301
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
4159-4314 2.11e-56

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 193.05  E-value: 2.11e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4159 RARLYFLLAWFHAIVQERLRYVPLGWAKKYEFNESDLRVACDTLDTWIDTtamgrtnlPPEKVPWDALVTLLSQSIYGGK 4238
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDE--------YDEKIPWDALRYLIGEINYGGR 72
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330856  4239 IDNDFDQRLLTSFLKKLFTARSFEADFALVANVdgasgglrhITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNA 4314
Cdd:pfam18198   73 VTDDWDRRLLNTYLEEFFNPEVLEEDFKFSPSL---------YYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
3186-3521 2.60e-44

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 166.40  E-value: 2.60e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3186 LNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMA 3265
Cdd:pfam12777    3 LENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKACEE 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3266 DLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAVVKLALESVCELLNESA-----TDWKAIRGILVK-DSFISSIVNL 3339
Cdd:pfam12777   83 DLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGkipkdKSWKAAKIMMAKvDGFLDSLIKF 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3340 ETDKITDDVREKMKSkYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLREELrsleEQADVNLASAKETk 3419
Cdd:pfam12777  163 DKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQAL----EEANADLAAAQEK- 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3420 dlVEQLERSIAAYKEEYAQLISQ-----AQAIKTDLENVQAKVDRSIA--LLKSLNIERERWESTSETFKSQMSTIIGDV 3492
Cdd:pfam12777  237 --LAAIKAKIAELNANLAKLTAAfekatADKIKCQQEADATARTILLAnrLVGGLASENIRWADAVENFKQQERTLCGDI 314
                          330       340       350
                   ....*....|....*....|....*....|
gi 221330856  3493 LLSAAFIAYGGYFDQHYRLNLF-TTWSQHL 3521
Cdd:pfam12777  315 LLISAFISYLGFFTKKYRNELLdKFWIPYI 344
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2551-2724 1.61e-42

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 155.24  E-value: 1.61e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2551 DIVVPTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALP--DMEVVGLNFSSATTPELLLKTFDHYCEYRK 2628
Cdd:pfam12775    9 EILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkeKYLPLFINFSAQTTSNQTQDIIESKLEKRR 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2629 tpnGVVLSPVqIGKWLVLFCDEINLPDMDSYGTQRVISFLRQLVEHKGFYRASDQAWVSLERIQFVGACNPPTdPGRKPL 2708
Cdd:pfam12775   89 ---KGVYGPP-GGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPG-GGRNDI 163
                          170
                   ....*....|....*.
gi 221330856  2709 SHRFLRHVPIIYVDYP 2724
Cdd:pfam12775  164 TPRLLRHFNVFNITFP 179
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
4019-4129 8.14e-37

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 136.42  E-value: 8.14e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  4019 NCNTPALLCSVPGFDASGRVDDLAAEQN--KQISSIAIGSAEGFnQAERAINMACKTGRWVLLKNVHLAPQWLVQLEKKM 4096
Cdd:pfam03028    1 SPTTPLIFILSPGSDPTADLEKLAKKLGfgGKLHSISLGQGQGP-IAEKLIEEAAKEGGWVLLQNCHLALSWMPELEKIL 79
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 221330856  4097 HSLQ---PHSGFRLFLTMEINPKVPVNLLRAGRIFV 4129
Cdd:pfam03028   80 EELPeetLHPDFRLWLTSEPSPKFPISILQNSIKIT 115
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
2408-2535 2.04e-22

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 95.43  E-value: 2.04e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2408 LLPFFsaDGIVVRTLEYAMDQ-EHIMDFTRLRALSSLFSMLNQAARNVLTFNAQHPdfpCSADQLEHYIPKALVYSVLWS 2486
Cdd:pfam17852    1 LEPLF--EWLVPPALEFVRKNcKEIVPTSDLNLVQSLCRLLESLLDEVLEYNGVHP---LSPDKLKEYLEKLFLFALVWS 75
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 221330856  2487 FAGDAKLKVRIDLGDFVRSVTT-VPLPGAAGAPIIDYEVNM-SGDWVPWSN 2535
Cdd:pfam17852   76 IGGTLDEDSRKKFDEFLRELFSgLDLPPPEKGTVYDYFVDLeKGEWVPWSD 126
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2205-2345 6.41e-15

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 74.64  E-value: 6.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2205 GLMMVGPSGSGKSTAWKTLLKALERFEGVEgvahVIDPKAISKEALYGVLDPNTR--EWTDGLFTHILRKiidnvrgein 2282
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRPVFY----VQLTRDTTEEDLFGRRNIDPGgaSWVDGPLVRAARE---------- 66
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330856  2283 krQWIIFDGDVD---PEWVENLNSVLDDNKLLTLPNGERLSLPP-NVRVMFEV----QDLKFATLATVSRC 2345
Cdd:pfam07728   67 --GEIAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVKAAPdGFRLIATMnpldRGLNELSPALRSRF 135
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2555-2718 9.88e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.93  E-value: 9.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2555 PTLDTVRHESLLYTWLAEHKPLVLCGPPGSGKTMTLFSALRAL--PDMEVVGLNFSSATTPELLLKTFDHYCEYRKTpng 2632
Cdd:cd00009     1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrPGAPFLYLNASDLLEGLVVAELFGHFLVRLLF--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2633 vvlSPVQIGKWLVLFCDEIN-LPDMDSYGTQRVISFLRQLVEhkgfyrasdqawvSLERIQFVGACNPPTDPG-RKPLSH 2710
Cdd:cd00009    78 ---ELAEKAKPGVLFIDEIDsLSRGAQNALLRVLETLNDLRI-------------DRENVRVIGATNRPLLGDlDRALYD 141

                  ....*...
gi 221330856 2711 RFLRHVPI 2718
Cdd:cd00009   142 RLDIRIVI 149
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
2573-2718 1.81e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.83  E-value: 1.81e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   2573 HKPLVLCGPPGSGKTMTLFSALRALPDMevvGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQI----------GK 2642
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPP---GGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRlrlalalarkLK 78
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330856   2643 WLVLFCDEI-NLPDMDSYGTQRVISFLRQLVEHKgfyrasdqawvSLERIQFVGACNPPTDPGRKPLSHRFLRHVPI 2718
Cdd:smart00382   79 PDVLILDEItSLLDAEQEALLLLLEELRLLLLLK-----------SEKNLTVILTTNDEKDLGPALLRRRFDRRIVL 144
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3133-3490 6.30e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 6.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3133 VYVHQTLHQANARLAKRGGRTMAVTPRHYLDFIHHFVklyNEKRSDLEEQQLHLNvglNKIAETVEQVEEMQKSLAVKKQ 3212
Cdd:TIGR02168  625 VLVVDDLDNALELAKKLRPGYRIVTLDGDLVRPGGVI---TGGSAKTNSSILERR---REIEELEEKIEELEEKIAELEK 698
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3213 ELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLAdqtvKIEEKRKYVMADLAQVEPAVIDAQAavssiKKKHLAEV 3292
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEELSRQISALRKDLA----RLEAEVEQLEERIAQLSKELTELEA-----EIEELEER 769
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3293 RSMANPPAVVKLA-LESVCELLNESATDWKAIRGILVKdsfISSIVNLETDKITdDVREKMkskylsnpdynfEKVNRAS 3371
Cdd:TIGR02168  770 LEEAEEELAEAEAeIEELEAQIEQLKEELKALREALDE---LRAELTLLNEEAA-NLRERL------------ESLERRI 833
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3372 MACGPMVKWAIAQIEyaDMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLIsqaqaikTDLE 3451
Cdd:TIGR02168  834 AATERRLEDLEEQIE--ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELS-------EELR 904
                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 221330856  3452 NVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIG 3490
Cdd:TIGR02168  905 ELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
3170-3464 3.22e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3170 KLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRL 3249
Cdd:COG1196   242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL 321
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3250 ADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKhLAEVRSmanppavvklALESVCELLNESATDWKAIRgilvk 3329
Cdd:COG1196   322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAE-LAEAEE----------ALLEAEAELAEAEEELEELA----- 385
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3330 dsfiSSIVNLETDKItddvrekmkskylsnpdynfEKVNRAsmacgpmvkwAIAQIEYADMLKRVEPLREELRSLEEQAD 3409
Cdd:COG1196   386 ----EELLEALRAAA--------------------ELAAQL----------EELEEAEEALLERLERLEEELEELEEALA 431
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221330856 3410 VNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIALL 3464
Cdd:COG1196   432 ELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
3169-3489 3.41e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 3.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3169 VKLYNEKRSDLEEQQLHLNVGLNKIAETVEQ----VEEMQKSLAVKKQEL-QAKNEAANAKlKQMFQDQQEAEK--KKI- 3240
Cdd:TIGR04523  206 LKKKIQKNKSLESQISELKKQNNQLKDNIEKkqqeINEKTTEISNTQTQLnQLKDEQNKIK-KQLSEKQKELEQnnKKIk 284
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3241 ----QSQEIQIRLAD-QTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKhLAEVRSMANPPAVVKLALESV-CELLN 3314
Cdd:TIGR04523  285 elekQLNQLKSEISDlNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKI-ISQLNEQISQLKKELTNSESEnSEKQR 363
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3315 ESATDWKAIRGILV-KDSFISSIVNLETDKitddvrEKMKSKYLSNPDYNFEKVNRASmacgpmvkwaIAQIEYADMLKR 3393
Cdd:TIGR04523  364 ELEEKQNEIEKLKKeNQSYKQEIKNLESQI------NDLESKIQNQEKLNQQKDEQIK----------KLQQEKELLEKE 427
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3394 VEPLRE-------ELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYaqlisqaQAIKTDLENVQAKVDRSIALLKS 3466
Cdd:TIGR04523  428 IERLKEtiiknnsEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSI-------NKIKQNLEQKQKELKSKEKELKK 500
                          330       340
                   ....*....|....*....|...
gi 221330856  3467 LNIERERWESTSETFKSQMSTII 3489
Cdd:TIGR04523  501 LNEEKKELEEKVKDLTKKISSLK 523
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2907-2997 4.24e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 46.76  E-value: 4.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 2907 IDRIFRQPQGHLLLIGVSGAGKTTLSRFVAW---MNGLSIFQIKVHNKYTSEDFDEDLRCVLRRS----GCKDEKIAFIL 2979
Cdd:cd00009    11 REALELPPPKNLLLYGPPGTGKTTLARAIANelfRPGAPFLYLNASDLLEGLVVAELFGHFLVRLlfelAEKAKPGVLFI 90
                          90
                  ....*....|....*...
gi 221330856 2980 DESNVLDSGFLERMNTLL 2997
Cdd:cd00009    91 DEIDSLSRGAQNALLRVL 108
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3189-3781 4.62e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.07  E-value: 4.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3189 GLNKIAETVEQVEEMQKSLAVKKQELQAKN---EAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRkyvMA 3265
Cdd:TIGR02169  242 IERQLASLEEELEKLTEEISELEKRLEEIEqllEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERE---LE 318
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3266 DLAQVEpavidaQAAVSSIKKKhLAEVRSMANPPAVVKLALESVCELLNESATDWKAIRGILVKDSFISSIVNLETDKIT 3345
Cdd:TIGR02169  319 DAEERL------AKLEAEIDKL-LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYR 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3346 ---DDVREKMKSkYLSNPDYNFEKVNRASMACGPMvKWAIAQIE--YADMLKRVEPLREELRSLEEQadvnlasAKETKD 3420
Cdd:TIGR02169  392 eklEKLKREINE-LKRELDRLQEELQRLSEELADL-NAAIAGIEakINELEEEKEDKALEIKKQEWK-------LEQLAA 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3421 LVEQLERSIAAYKEEYAQlisqaqaIKTDLENVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVllsAAFIA 3500
Cdd:TIGR02169  463 DLSKYEQELYDLKEEYDR-------VEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV---AQLGS 532
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3501 YggyfDQHYRLNLFTTWSQHLQAASIQYRADIART-EYLSnpdERLRWQANALPTDDlctenaimLKRFNRYPLIIDPSG 3579
Cdd:TIGR02169  533 V----GERYATAIEVAAGNRLNNVVVEDDAVAKEAiELLK---RRKAGRATFLPLNK--------MRDERRDLSILSEDG 597
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3580 qATTFLLNeyagkkitktsFLDdsFRKNLESALR--FGNPLLVQDVEnydpilnpvlnrELRRTGGRV-LITLgDQDIdL 3656
Cdd:TIGR02169  598 -VIGFAVD-----------LVE--FDPKYEPAFKyvFGDTLVVEDIE------------AARRLMGKYrMVTL-EGEL-F 649
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3657 SPSFVIflstrdptvefppdicsrvtfvnftvTRSSLQSQCLNQVLKAERPDIDEKRSDLLKLQGEF------RLRLRQL 3730
Cdd:TIGR02169  650 EKSGAM--------------------------TGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELsslqseLRRIENR 703
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 221330856  3731 EKSLLQALNDAKGKILDDDSVITTL----ETLKKEAYDINQKVDETDKVIAEIET 3781
Cdd:TIGR02169  704 LDELSQELSDASRKIGEIEKEIEQLeqeeEKLKERLEELEEDLSSLEQEIENVKS 758
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
3190-3305 5.21e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3190 LNKIAE----TVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMA 3265
Cdd:COG3883   124 LSKIADadadLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEA 203
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 221330856 3266 DLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAVVKLA 3305
Cdd:COG3883   204 ELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 243
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3172-3468 6.16e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.67  E-value: 6.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3172 YNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKslavKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQEIQIRLAD 3251
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKLEELRLEVSELEE----EIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3252 QTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANppavVKLALESVCELLNESATDWKAIRgiLVKDS 3331
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEE----LESRLEELEEQLETLRSKVAQLE--LQIAS 397
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3332 FISSIVNLETDK-ITDDVREKMKSkylSNPDYNFEKVNrasmacgpmvkwaiAQIEYADMlkRVEPLREELRSLEEQADV 3410
Cdd:TIGR02168  398 LNNEIERLEARLeRLEDRRERLQQ---EIEELLKKLEE--------------AELKELQA--ELEELEEELEELQEELER 458
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 221330856  3411 NLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIALLKSLN 3468
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2575-2714 1.17e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.98  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  2575 PLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRKTPNGVVLSPVQIGKwlVLFCDEINLP 2654
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRNIDPGGASWVDGPLVRAAREGE--IAVLDEINRA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221330856  2655 DMDsygtqrVISFLRQLVEHKGFYRASD--QAWVSLERIQFVGACNPPtDPGRKPLSHRFLR 2714
Cdd:pfam07728   79 NPD------VLNSLLSLLDERRLLLPDGgeLVKAAPDGFRLIATMNPL-DRGLNELSPALRS 133
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3172-3786 1.21e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3172 YNEKRSDLEEQQLHLNVG-----LNKIAETVEQVEEMQ---KSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQSQ 3243
Cdd:TIGR02168  215 YKELKAELRELELALLVLrleelREELEELQEELKEAEeelEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3244 EIQIRLADQTVKIEEKRKYVMADLAQVEpAVIDAQAAVSSIKKKHLAEVRSMANPPAVVKLALEsvcELLNESATDWKAI 3323
Cdd:TIGR02168  295 NEISRLEQQKQILRERLANLERQLEELE-AQLEELESKLDELAEELAELEEKLEELKEELESLE---AELEELEAELEEL 370
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3324 RGILVKDsfissivnletdkitDDVREKMKSKYLSNpdYNFEKVNRasmacgpmvkwaiAQIEYADMLK-----RVEPLR 3398
Cdd:TIGR02168  371 ESRLEEL---------------EEQLETLRSKVAQL--ELQIASLN-------------NEIERLEARLerledRRERLQ 420
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3399 EELRSLEEQADVNLASA---------KETKDLVEQLERSIAAYKEEYAQLisqaQAIKTDLENVQAKVDRSIALLKSLNI 3469
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaeleeleEELEELQEELERLEEALEELREEL----EEAEQALDAAERELAQLQARLDSLER 496
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3470 ERERWESTSETFK------SQMSTIIGDV--LLSaafiayggyFDQHYRLNLFTTWSQHLQAasiqyradiarteYLSNP 3541
Cdd:TIGR02168  497 LQENLEGFSEGVKallknqSGLSGILGVLseLIS---------VDEGYEAAIEAALGGRLQA-------------VVVEN 554
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3542 DERLRWQANALptddlcTENAimlkrfnrypliidpSGQATTFLLNEYAGKKITKTsflDDSFRKNLESALRFGNpllvq 3621
Cdd:TIGR02168  555 LNAAKKAIAFL------KQNE---------------LGRVTFLPLDSIKGTEIQGN---DREILKNIEGFLGVAK----- 605
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3622 DVENYDPILNPVLNRELrrtgGRVLITlgdQDID--------LSPSFVIFlsTRDPTVEFPpdicsrvtfvNFTVTRSSL 3693
Cdd:TIGR02168  606 DLVKFDPKLRKALSYLL----GGVLVV---DDLDnalelakkLRPGYRIV--TLDGDLVRP----------GGVITGGSA 666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3694 QSqclNQVLKAERPDIDEKRSDLLKLQGEFRlrlrqlekSLLQALNDAKGKILDDDSVittLETLKKEAYDINQKVDETD 3773
Cdd:TIGR02168  667 KT---NSSILERRREIEELEEKIEELEEKIA--------ELEKALAELRKELEELEEE---LEQLRKELEELSRQISALR 732
                          650
                   ....*....|...
gi 221330856  3774 KVIAEIETVSQQY 3786
Cdd:TIGR02168  733 KDLARLEAEVEQL 745
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3159-3497 1.64e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3159 RHYLDFIHHFVKLYN--EKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAE 3236
Cdd:COG4717   115 REELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEEL 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3237 K---KKIQSQEIQIRLADQTVK-IEEKRKYVMADLAQVEPAVIDAQ---------------AAVSSIKKKHLAEVRSMAN 3297
Cdd:COG4717   195 QdlaEELEELQQRLAELEEELEeAQEELEELEEELEQLENELEAAAleerlkearlllliaAALLALLGLGGSLLSLILT 274
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3298 PPAVVKLALESVCELLNESATDWKAIRGILVKDSFISSIVNLETDKITDDVREKMKSKYLSnPDYNFEKVNRASMACGPM 3377
Cdd:COG4717   275 IAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLS-PEELLELLDRIEELQELL 353
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3378 VKWAIAQIEYadmlkRVEPLREELRSLEEQADVN----LASAKETKDLVEQLERSIAAYKEEYAQLIS--QAQAIKTDLE 3451
Cdd:COG4717   354 REAEELEEEL-----QLEELEQEIAALLAEAGVEdeeeLRAALEQAEEYQELKEELEELEEQLEELLGelEELLEALDEE 428
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 221330856 3452 NVQAKVDRSIALLKSLNIERERWESTSETFKSQMSTIIGDVLLSAA 3497
Cdd:COG4717   429 ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAEL 474
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
3174-3326 2.69e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 46.79  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3174 EKRSDLEEQQLH--LNVGLNKIAETveqveemQKSLAVKKQELQAKNEAANAKLKQMFQDQQEAEKKKIQsQEIQIRLAD 3251
Cdd:COG2268   218 QANREAEEAELEqeREIETARIAEA-------EAELAKKKAEERREAETARAEAEAAYEIAEANAEREVQ-RQLEIAERE 289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3252 QTVKIEEKRKYV---MADLAQVEPAVIDAQAAV-------SSIK---------KKHLAEVRSMANPPAVVKLALESVCEL 3312
Cdd:COG2268   290 REIELQEKEAEReeaELEADVRKPAEAEKQAAEaeaeaeaEAIRakglaeaegKRALAEAWNKLGDAAILLMLIEKLPEI 369
                         170
                  ....*....|....
gi 221330856 3313 LNESAtdwKAIRGI 3326
Cdd:COG2268   370 AEAAA---KPLEKI 380
PRK01156 PRK01156
chromosome segregation protein; Provisional
3163-3488 5.69e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.43  E-value: 5.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3163 DFIHHFVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQElqakneaanaklkqmfqdQQEAEKKKIQS 3242
Cdd:PRK01156  465 EKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEIN------------------KSINEYNKIES 526
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3243 QEIQIrladqtvkieekrKYVMADLAQVEPAVIDAQAAVSSIKKKHLaevrsmanppavvklalesvcELLNESATDWka 3322
Cdd:PRK01156  527 ARADL-------------EDIKIKINELKDKHDKYEEIKNRYKSLKL---------------------EDLDSKRTSW-- 570
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3323 irgiLVKDSFISSIVNLETDKITDDVREKMKS--KYLSNPDYNFEKVNrasmacgpmvkwaiaqiEYAD-MLKRVEplrE 3399
Cdd:PRK01156  571 ----LNALAVISLIDIETNRSRSNEIKKQLNDleSRLQEIEIGFPDDK-----------------SYIDkSIREIE---N 626
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3400 ELRSLEEQadVNLASAKetKDLVEQLERSIAAYKEEYA----------QLISQAQAIKTDLENVQAKVDRSiallkslNI 3469
Cdd:PRK01156  627 EANNLNNK--YNEIQEN--KILIEKLRGKIDNYKKQIAeidsiipdlkEITSRINDIEDNLKKSRKALDDA-------KA 695
                         330
                  ....*....|....*....
gi 221330856 3470 ERERWESTSETFKSQMSTI 3488
Cdd:PRK01156  696 NRARLESTIEILRTRINEL 714
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
1894-2006 7.68e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.13  E-value: 7.68e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   1894 FGPAGTGKTESVKALGNQLGR---FVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSACSQQ---IQTI 1967
Cdd:smart00382    8 VGPPGSGKTTLARALARELGPpggGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDvliLDEI 87
                            90       100       110
                    ....*....|....*....|....*....|....*....
gi 221330856   1968 QEALKYEMDSNKESITVELVGKQVRVSPDMAIFITMNPG 2006
Cdd:smart00382   88 TSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDE 126
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3173-3472 7.75e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3173 NEKRSDLEEQQLHLNVGLNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMFQDQQE-----AEKKKIQSQ--EI 3245
Cdd:COG4372    62 EQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKErqdleQQRKQLEAQiaEL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3246 QIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAVVKLALESVCELLNESATDWKAIRG 3325
Cdd:COG4372   142 QSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELL 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3326 ILVKDSFISSIVNLEtdKITDDVREKMKSKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVEPLREELRslE 3405
Cdd:COG4372   222 EAKDSLEAKLGLALS--ALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELK--L 297
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330856 3406 EQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIALLKSLNIERE 3472
Cdd:COG4372   298 LALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAE 364
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
3168-3472 1.12e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.33  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3168 FVKLYNEKRSDLEEQQLHLNVGLNKIAETVEQVEEM-QKSLAVKKQELQAKNEAANAKLKQMFQDQQE-AEKKK------ 3239
Cdd:COG5185   230 NIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLrLEKLGENAESSKRLNENANNLIKQFENTKEKiAEYTKsidikk 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3240 -IQSQEIQIRLADQTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAV---------VKLALESV 3309
Cdd:COG5185   310 aTESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELsksseeldsFKDTIEST 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3310 CELLNESATDWKAiRGILVKDSFISSIVNLETDkitddvREKMKSKYLSNPDYNFE--KVNRASMACGPMVKWAIAQIEY 3387
Cdd:COG5185   390 KESLDEIPQNQRG-YAQEILATLEDTLKAADRQ------IEELQRQIEQATSSNEEvsKLLNELISELNKVMREADEESQ 462
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3388 ADMLKRVEPLREELRSleeqadvnlaSAKETKDLVEQLERSIAAYKEEYAQLISqaqAIKTDLENVQAKVDRSIALLKSL 3467
Cdd:COG5185   463 SRLEEAYDEINRSVRS----------KKEDLNEELTQIESRVSTLKATLEKLRA---KLERQLEGVRSKLDQVAESLKDF 529

                  ....*
gi 221330856 3468 NIERE 3472
Cdd:COG5185   530 MRARG 534
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3173-3427 1.20e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3173 NEKRSDLEEQQLHLNVGLNKIAETVEQVEEmqkslavKKQELQAKNEAANAKlKQMFQDQQEAEKKKIQS-----QEIQI 3247
Cdd:TIGR02169  804 EEEVSRIEARLREIEQKLNRLTLEKEYLEK-------EIQELQEQRIDLKEQ-IKSIEKEIENLNGKKEEleeelEELEA 875
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3248 RLAD---QTVKIEEKRKYVMADLAQVEPAVIDAQAAVSsIKKKHLAEVrsmanppavvKLALESVCELLnesatdwKAIR 3324
Cdd:TIGR02169  876 ALRDlesRLGDLKKERDELEAQLRELERKIEELEAQIE-KKRKRLSEL----------KAKLEALEEEL-------SEIE 937
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3325 GILVKDSFISsivnlETDKITDDVREKMkskylsnpdynfEKVNRASMACGPMVKWAIAqiEYADMLKRVEPLREELRSL 3404
Cdd:TIGR02169  938 DPKGEDEEIP-----EEELSLEDVQAEL------------QRVEEEIRALEPVNMLAIQ--EYEEVLKRLDELKEKRAKL 998
                          250       260
                   ....*....|....*....|...
gi 221330856  3405 EEQadvnlasAKETKDLVEQLER 3427
Cdd:TIGR02169  999 EEE-------RKAILERIEEYEK 1014
Muted pfam14942
Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to ...
3165-3261 2.36e-03

Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms. The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system.


Pssm-ID: 464390 [Multi-domain]  Cd Length: 146  Bit Score: 41.49  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3165 IHHFVKLYNEKRSDLEEQQLHlNVgLNKIAETVEQV-EEMQKSLAVKKQELQAKNEAANAKLKQMFQdqqeaekkkiQSQ 3243
Cdd:pfam14942   22 IKYFLKEFEEKRGDREVRRLE-NI-TEMINETNENIlPKCKQSMEDNLSELLSKLDAALNMCERLLQ----------REL 89
                           90
                   ....*....|....*...
gi 221330856  3244 EIQIRLADQTVKIEEKRK 3261
Cdd:pfam14942   90 EEEQRKNDRLQENEEQRK 107
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3192-3487 3.30e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3192 KIAETVEQVEEMQKSLAVKKQEL-QAKNEaanakLKQMFQDQQEAEKKKIQSQEIQIRLADQTVKIEEKRKYVMADLAQV 3270
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELrRIENR-----LDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL 749
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3271 EpaviDAQAAVSSIKKKHLAEVRSMANPPAVVKLALESVCELLNESAtdWKAIRGILvkdSFISSIVNlETDKITDDVRE 3350
Cdd:TIGR02169  750 E----QEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSR--IPEIQAEL---SKLEEEVS-RIEARLREIEQ 819
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856  3351 KMKSKYLsnpdynfekvnrasmacgpmvkwaiaQIEYADmlKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIA 3430
Cdd:TIGR02169  820 KLNRLTL--------------------------EKEYLE--KEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE 871
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 221330856  3431 AYKEEYAQLISQaqaiktdLENVQAKVDRSIALLKSLNIERERWESTSETFKSQMST 3487
Cdd:TIGR02169  872 ELEAALRDLESR-------LGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE 921
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
2914-3076 4.09e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 4.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   2914 PQGHLLLIGVSGAGKTTLSRFVAWMNGLSIFQIKVHNkytsedfDEDLRCVLRrsgckdEKIAFILDESNVLDSGFLERM 2993
Cdd:smart00382    1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYID-------GEDILEEVL------DQLLLIIVGGKKASGSGELRL 67
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856   2994 NTL--LANGEVPG-LFEgDEYTTLMTqckegaQREGLMLDSSDELYKWFTQQVMRNLHVVFTMNPSTDglKDRAATSPAL 3070
Cdd:smart00382   68 RLAlaLARKLKPDvLIL-DEITSLLD------AEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKD--LGPALLRRRF 138

                    ....*.
gi 221330856   3071 FNRCVL 3076
Cdd:smart00382  139 DRRIVL 144
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
3383-3484 4.94e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3383 AQIEYADMLKRVEPLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIA 3462
Cdd:COG1196   286 AQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE 365
                          90       100
                  ....*....|....*....|..
gi 221330856 3463 LLKSLNIERERWESTSETFKSQ 3484
Cdd:COG1196   366 ALLEAEAELAEAEEELEELAEE 387
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
3191-3258 6.14e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 38.41  E-value: 6.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330856 3191 NKIAETVEQVEEMQ---KSLAVKKQELQAKNEAANAKLKQMfqdQQEAEKKKIQSQEIQIRLADQTVKIEE 3258
Cdd:COG3074    11 AKVQQAVDTIELLQmevEELKEKNEELEQENEELQSENEEL---QSENEQLKTENAEWQERIRSLLGKIDE 78
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
3174-3502 8.04e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 42.33  E-value: 8.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3174 EKRSDLEEQQLHLNVGLNKIAETVEQ-VEEMQKSLAVKKQELQAKNEAA--------NAKLKQMFQDQQEAEKKKIQSQE 3244
Cdd:COG3064    59 EAKAEAEQRAAELAAEAAKKLAEAEKaAAEAEKKAAAEKAKAAKEAEAAaaaekaaaAAEKEKAEEAKRKAEEEAKRKAE 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3245 IQIRLAD---------QTVKIEEKRKYVMADLAQVEPAVIDAQAAVSSIKKKHLAEVRSMANPPAVVKLALESVCELLNE 3315
Cdd:COG3064   139 EERKAAEaeaaakaeaEAARAAAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLA 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3316 SATDWKAIRGILVKDSFISSIVNLETDKITDDVREKMKSKYLSNPDYNFEKVNRASMACGPMVKWAIAQIEYADMLKRVE 3395
Cdd:COG3064   219 LAVAARAAAASREAALAAVEATEEAALGGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLD 298
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3396 PLREELRSLEEQADVNLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDRSIALLKSLNIERERWE 3475
Cdd:COG3064   299 DSAALAAELLGAVAAEEAVLAAAAAAGALVVRGGGAASLEAALSLLAAGAAAAAAGAGALATGALGDALAAEAAGALLLG 378
                         330       340
                  ....*....|....*....|....*..
gi 221330856 3476 STSETFKSQMSTIIGDVLLSAAFIAYG 3502
Cdd:COG3064   379 KLADVEEAAGAGILAAAGGGGLLGLRL 405
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
3381-3480 8.13e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3381 AIAQI-EYADMLKRVEPLREELRSLEEQadvnLASAKETKDLVEQLERSIAAYKEEYAQLISQAQAIKTDLENVQAKVDR 3459
Cdd:COG4913   649 ALQRLaEYSWDEIDVASAEREIAELEAE----LERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQ 724
                          90       100
                  ....*....|....*....|.
gi 221330856 3460 SIALLKSLNIERERWESTSET 3480
Cdd:COG4913   725 AEEELDELQDRLEAAEDLARL 745
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
2573-2602 8.50e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 42.10  E-value: 8.50e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 221330856 2573 HKP--LVL-CGPPGSGKTMTLFSALRALPDMEV 2602
Cdd:COG2804   310 RRPhgIILvTGPTGSGKTTTLYAALNELNTPER 342
PRK12704 PRK12704
phosphodiesterase; Provisional
3172-3287 9.54e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 9.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330856 3172 YNEKRSDLEEQQlhlnvglNKIAETVEQVEEMQKSLAVKKQELQAKNEAANAKLKQMfqDQQEAEKKKIQSQEIQI--RL 3249
Cdd:PRK12704   77 LRERRNELQKLE-------KRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQEL--EKKEEELEELIEEQLQEleRI 147
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 221330856 3250 ADQTVkiEEKRKYVMADLaqVEPAVIDAQAAVSSIKKK 3287
Cdd:PRK12704  148 SGLTA--EEAKEILLEKV--EEEARHEAAVLIKEIEEE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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