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Conserved domains on  [gi|24659264|ref|NP_729155|]
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transportin, isoform C [Drosophila melanogaster]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-754 2.77e-22

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 103.09  E-value: 2.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  22 SPDTATQMAVQMKLEEFNRyPDFNNY---LIYVLTKLKTEDEpTRSLSGLILKNNIRMHGTTLQ-----------PEIVE 87
Cdd:COG5215  16 SPDPNARLRAEAQLLELQS-GDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANDPELQkgcsqrwlgmrHESKE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  88 YIKHECLQAVGDASPLIRATVGILITTIASNGGLHN-WPQLLPSLCEML-DNQDYNVCEGAFSALQKICEDSaeilDSAA 165
Cdd:COG5215  94 QVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNSlWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APED 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 166 LNRPLNIMIPKFLEYFKHSSP--KIRSHAIACIN------QFIINRSQalmlNIDSFIENLFHLSSDEDHEVRKNVCHGL 237
Cdd:COG5215 170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMdslmfvQGNFCYEE----ERNYFMQVVCEATQGNDEELQHAAFGCL 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 238 VMLLEVRMDRLMPHMSQIIEYMLLRT-QDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDII-- 314
Cdd:COG5215 246 NKIMMLYYKFMQSYMENALAALTGRFmKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpe 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 315 LLKGNVEEDdmvPDREEDirprfhksrahtirstqeggagatgdddddefedgmdddsslsEWNLRKCSAAALDVLANVF 394
Cdd:COG5215 326 LLSLLEKQG---EDYYGD-------------------------------------------DWNPSMAASSCLQLFAQLK 359

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 395 REDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEG-CMQGMIQHLPELIPYLISCLSDKKALVRSITCWTLSRYANWV 473
Cdd:COG5215 360 GDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV 439

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 474 VNQ-PHDQYLKPLMEELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLEYILKTLVFAFSKYQHKNLL- 543
Cdd:COG5215 440 AMIiSPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLr 517

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 544 -ILYDAVGTL----ADSVGHHLnkPQYIDILMPPL-----IDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVY 613
Cdd:COG5215 518 vSLFSALGTLilicPDAVSDIL--AGFYDYTSKKLdecisVLGQILATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVE 595

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 614 RRCISLIEQTINqemlcKQNQTYDHPDKERMIVAldLLSGLAEGLDRHIETLVAnsnimhLLYQCMQDVLPEVRQSSFAL 693
Cdd:COG5215 596 DQLMELFIRILE-----STKPTTAFGDVYTAISA--LSTSLEERFEQYASKFIP------YLTRALNCTDRFVLNSAVGL 662

                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 694 LGDLTKACFPHVHPFMADFFPILGQ---------NLNPDFISVcnnatwaIGEICMKLGEETKQYIRLVL 754
Cdd:COG5215 663 VGDLANTLGTDFNIYADVLMSSLVQclsseathrDLKPAILSV-------FGDIALAIGANFESYLDMIM 725
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-754 2.77e-22

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 103.09  E-value: 2.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  22 SPDTATQMAVQMKLEEFNRyPDFNNY---LIYVLTKLKTEDEpTRSLSGLILKNNIRMHGTTLQ-----------PEIVE 87
Cdd:COG5215  16 SPDPNARLRAEAQLLELQS-GDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANDPELQkgcsqrwlgmrHESKE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  88 YIKHECLQAVGDASPLIRATVGILITTIASNGGLHN-WPQLLPSLCEML-DNQDYNVCEGAFSALQKICEDSaeilDSAA 165
Cdd:COG5215  94 QVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNSlWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APED 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 166 LNRPLNIMIPKFLEYFKHSSP--KIRSHAIACIN------QFIINRSQalmlNIDSFIENLFHLSSDEDHEVRKNVCHGL 237
Cdd:COG5215 170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMdslmfvQGNFCYEE----ERNYFMQVVCEATQGNDEELQHAAFGCL 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 238 VMLLEVRMDRLMPHMSQIIEYMLLRT-QDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDII-- 314
Cdd:COG5215 246 NKIMMLYYKFMQSYMENALAALTGRFmKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpe 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 315 LLKGNVEEDdmvPDREEDirprfhksrahtirstqeggagatgdddddefedgmdddsslsEWNLRKCSAAALDVLANVF 394
Cdd:COG5215 326 LLSLLEKQG---EDYYGD-------------------------------------------DWNPSMAASSCLQLFAQLK 359

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 395 REDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEG-CMQGMIQHLPELIPYLISCLSDKKALVRSITCWTLSRYANWV 473
Cdd:COG5215 360 GDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV 439

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 474 VNQ-PHDQYLKPLMEELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLEYILKTLVFAFSKYQHKNLL- 543
Cdd:COG5215 440 AMIiSPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLr 517

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 544 -ILYDAVGTL----ADSVGHHLnkPQYIDILMPPL-----IDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVY 613
Cdd:COG5215 518 vSLFSALGTLilicPDAVSDIL--AGFYDYTSKKLdecisVLGQILATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVE 595

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 614 RRCISLIEQTINqemlcKQNQTYDHPDKERMIVAldLLSGLAEGLDRHIETLVAnsnimhLLYQCMQDVLPEVRQSSFAL 693
Cdd:COG5215 596 DQLMELFIRILE-----STKPTTAFGDVYTAISA--LSTSLEERFEQYASKFIP------YLTRALNCTDRFVLNSAVGL 662

                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 694 LGDLTKACFPHVHPFMADFFPILGQ---------NLNPDFISVcnnatwaIGEICMKLGEETKQYIRLVL 754
Cdd:COG5215 663 VGDLANTLGTDFNIYADVLMSSLVQclsseathrDLKPAILSV-------FGDIALAIGANFESYLDMIM 725
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 415-469 7.33e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 66.62  E-value: 7.33e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24659264   415 WVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKALVRSITCWTLSRY 469
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 32-99 2.11e-07

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 48.78  E-value: 2.11e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24659264     32 QMKLEEFNRYPDFNNYLIYVLTKlkTEDEPTRSLSGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGD 99
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-754 2.77e-22

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 103.09  E-value: 2.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  22 SPDTATQMAVQMKLEEFNRyPDFNNY---LIYVLTKLKTEDEpTRSLSGLILKNNIRMHGTTLQ-----------PEIVE 87
Cdd:COG5215  16 SPDPNARLRAEAQLLELQS-GDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANDPELQkgcsqrwlgmrHESKE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  88 YIKHECLQAVGDASPLIRATVGILITTIASNGGLHN-WPQLLPSLCEML-DNQDYNVCEGAFSALQKICEDSaeilDSAA 165
Cdd:COG5215  94 QVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNSlWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APED 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 166 LNRPLNIMIPKFLEYFKHSSP--KIRSHAIACIN------QFIINRSQalmlNIDSFIENLFHLSSDEDHEVRKNVCHGL 237
Cdd:COG5215 170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMdslmfvQGNFCYEE----ERNYFMQVVCEATQGNDEELQHAAFGCL 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 238 VMLLEVRMDRLMPHMSQIIEYMLLRT-QDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDII-- 314
Cdd:COG5215 246 NKIMMLYYKFMQSYMENALAALTGRFmKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpe 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 315 LLKGNVEEDdmvPDREEDirprfhksrahtirstqeggagatgdddddefedgmdddsslsEWNLRKCSAAALDVLANVF 394
Cdd:COG5215 326 LLSLLEKQG---EDYYGD-------------------------------------------DWNPSMAASSCLQLFAQLK 359

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 395 REDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEG-CMQGMIQHLPELIPYLISCLSDKKALVRSITCWTLSRYANWV 473
Cdd:COG5215 360 GDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV 439

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 474 VNQ-PHDQYLKPLMEELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLEYILKTLVFAFSKYQHKNLL- 543
Cdd:COG5215 440 AMIiSPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLr 517

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 544 -ILYDAVGTL----ADSVGHHLnkPQYIDILMPPL-----IDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVY 613
Cdd:COG5215 518 vSLFSALGTLilicPDAVSDIL--AGFYDYTSKKLdecisVLGQILATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVE 595

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 614 RRCISLIEQTINqemlcKQNQTYDHPDKERMIVAldLLSGLAEGLDRHIETLVAnsnimhLLYQCMQDVLPEVRQSSFAL 693
Cdd:COG5215 596 DQLMELFIRILE-----STKPTTAFGDVYTAISA--LSTSLEERFEQYASKFIP------YLTRALNCTDRFVLNSAVGL 662

                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 694 LGDLTKACFPHVHPFMADFFPILGQ---------NLNPDFISVcnnatwaIGEICMKLGEETKQYIRLVL 754
Cdd:COG5215 663 VGDLANTLGTDFNIYADVLMSSLVQclsseathrDLKPAILSV-------FGDIALAIGANFESYLDMIM 725
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 415-469 7.33e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 66.62  E-value: 7.33e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24659264   415 WVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKALVRSITCWTLSRY 469
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
32-99 7.77e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 58.79  E-value: 7.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24659264    32 QMKLEEFNRYPDFNNYLIYVLTKLKTeDEPTRSLSGLILKNNIRMH----GTTLQPEIVEYIKHECLQAVGD 99
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHweeeKNSLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 32-99 2.11e-07

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 48.78  E-value: 2.11e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24659264     32 QMKLEEFNRYPDFNNYLIYVLTKlkTEDEPTRSLSGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGD 99
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
HEAT COG1413
HEAT repeat [General function prediction only];
384-524 3.91e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 3.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 384 AAALDVLANVFREDCLPVVLPILKetlfHQEWVIKESGVLALGAIAEgcmqgmiqhlPELIPYLISCLSDKKALVRSITC 463
Cdd:COG1413   3 RAAARALGRLGDPAAVPALIAALA----DEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24659264 464 WTLSRYANwvvnqphDQYLKPLMeELLKrilDSNKRVQEAACSAFATL-EEEACTELVPYLE 524
Cdd:COG1413  69 EALGRIGD-------PEAVPALI-AALK---DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 12-186 8.10e-05

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 46.34  E-value: 8.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  12 QIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNnYLIYVLTKLKTEDEPTRSLSGLILKNNIRMH-----GTTLQPEIV 86
Cdd:COG5657   5 PVVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHwreenGNSILPDEN 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  87 EYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPSLCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAAL 166
Cdd:COG5657  84 VLIRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDAL 163

                       170       180
                ....*....|....*....|
gi 24659264 167 NRPLNIMIPKFLEYFKHSSP 186
Cdd:COG5657 164 FLEIAPVLLSILCPFLFSSA 183
HEAT COG1413
HEAT repeat [General function prediction only];
125-274 2.35e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 2.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 125 PQLLPSLCEMLDNQDYNVCEGAFSALQKICEDSAeildsaalnrplnimIPKFLEYFKHSSPKIRSHAIACINQfiINRS 204
Cdd:COG1413  15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGR--IGDP 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 205 QAlmlnidsfIENLFHLSSDEDHEVRKNVCHGLVMLLEVRmdrlmphmsqIIEYMLLRTQDTDEGVALEA 274
Cdd:COG1413  78 EA--------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAA 129
HEAT COG1413
HEAT repeat [General function prediction only];
94-237 1.82e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.61  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264  94 LQAVGDASPLIRAT-VGILittiasngGLHNWPQLLPSLCEMLDNQDYNVCEGAFSALqkicedsAEILDSAAlnrplni 172
Cdd:COG1413  22 IAALADEDPDVRAAaARAL--------GRLGDPRAVPALLEALKDPDPEVRAAAAEAL-------GRIGDPEA------- 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24659264 173 mIPKFLEYFKHSSPKIRSHAIACINQfiinrsqalmLNIDSFIENLFHLSSDEDHEVRKNVCHGL 237
Cdd:COG1413  80 -VPALIAALKDEDPEVRRAAAEALGR----------LGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
417-587 5.51e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.07  E-value: 5.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 417 IKESGVLALGAIAEgcmqgmiqhlPELIPYLISCLSDKKALVRSITCWTLSRYANwvvnqphdqylKPLMEELLKRILDS 496
Cdd:COG1413   1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDP 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 497 NKRVQEAACSAFATL-EEEACTELVPYLeyilktlvfafskyQHKNLLILYDAVGTLAdsvghHLNKPQYIDILMPplid 575
Cdd:COG1413  60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAVPALLE---- 116

                       170
                ....*....|..
gi 24659264 576 kwnLLKDDDKDL 587
Cdd:COG1413 117 ---ALKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
384-470 7.41e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.69  E-value: 7.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659264 384 AAALDVLANVFREDclpvVLPILKETLFHQEWVIKESGVLALGAIAEgcmqgmiqhlPELIPYLISCLSDKKALVRSITC 463
Cdd:COG1413  65 AAAAEALGRIGDPE----AVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAA 130


                ....*..
gi 24659264 464 WTLSRYA 470
Cdd:COG1413 131 RALGRLG 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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