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Conserved domains on  [gi|442631782|ref|NP_729748|]
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cubulin 2 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1066-1179 1.25e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 135.23  E-value: 1.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1066 CGGTFTA-RFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYC 1144
Cdd:cd00041     1 CGGTLTAsTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLE---SSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442631782 1145 GNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQ 1179
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1754-1862 8.09e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.97  E-value: 8.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1754 CGGNITSA-SGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRS--SVQGPLLALYCDKN 1830
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDgpSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442631782 1831 LPETPLVVHSELWIKFRSRPGNTAGGFRFRWT 1862
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 624-738 6.49e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 6.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  624 CGETInlTSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEasagNCSQDSLIVYDSD----RQLL 699
Cdd:cd00041     1 CGGTL--TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSP----NCSYDYLEIYDGPstssPLLG 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442631782  700 RACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEV 738
Cdd:cd00041    75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3029-3143 5.54e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.41  E-value: 5.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 3029 CGGNYSTSF--TLRPPQNEDSsvYAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRtGLLC 3106
Cdd:cd00041     1 CGGTLTASTsgTISSPNYPNN--YPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLL-GRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782 3107 GNvTNPETIIVNSNEALIVLTTDSSNSYRGFLASVRF 3143
Cdd:cd00041    78 GS-TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 503-619 6.29e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.02  E-value: 6.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  503 CGVTIRGP-SGQLHYP--PNtadgDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRF 579
Cdd:cd00041     1 CGGTLTAStSGTISSPnyPN----NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 442631782  580 CGSRLPmtnGSVITTQEQVFFWFRSDNQTQGKGFHVIWNS 619
Cdd:cd00041    77 CGSTLP---PPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1303-1406 1.10e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1303 QGAIETPNFPENYPPGQDCEWDIRAGGRKnHLQLIFSHLSVEkFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITT 1382
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGY-RIRLTFEDFDLE-SSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIIS 87

                          90       100
                  ....*....|....*....|....
gi 442631782 1383 VGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:cd00041    88 SGNSLTVRFRSDSSVTGRGFKATY 111
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2210-2321 3.85e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 3.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2210 CNGEIQLNqqaPNYTIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEQFELSARHCDKENVEFFDGATKLARLLLRTC 2289
Cdd:cd00041     1 CGGTLTAS---TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 442631782 2290 -RKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLN 2321
Cdd:cd00041    78 gSTLPPPIISSGNSLTVRFRSDSSVTGRGFKAT 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1530-1648 3.71e-18

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 82.85  E-value: 3.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1530 CGGYISAS-SGVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEI 1608
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPN--------NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 442631782 1609 fLEKTCGEDSPMIRIVHGRKLRVRFKSQA-GTWGRFIMYFE 1648
Cdd:cd00041    73 -LGRFCGSTLPPPIISSGNSLTVRFRSDSsVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1979-2091 5.52e-18

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 82.08  E-value: 5.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1979 CTKELTLSHHGDIelSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIQSSRDlIKWKNELHA 2058
Cdd:cd00041     1 CGGTLTASTSGTI--SSPNYPNNYPNNLNCVWTIEAP-PGYRIRLTFEDFDLESSPNCSYDYLEIYDGPS-TSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782 2059 CKASQIAPVH-GTPYLRLQFRSDVSINGTGFRAK 2091
Cdd:cd00041    77 CGSTLPPPIIsSGNSLTVRFRSDSSVTGRGFKAT 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 745-854 1.61e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 75.14  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  745 CGGVYTESR-GRIS------GYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSh 817
Cdd:cd00041     1 CGGTLTASTsGTISspnypnNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782  818 eeSELEPIISIGNVILVRYEYALSGVRlsKSFDLTYT 854
Cdd:cd00041    80 --TLPPPIISSGNSLTVRFRSDSSVTG--RGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2327-2441 9.79e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.83  E-value: 9.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2327 CGGQFSASA-GFISSENYPhlGGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGtSSDRLEIVDYEDRTQKLMvldG 2405
Cdd:cd00041     1 CGGTLTASTsGTISSPNYP--NNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNC-SYDYLEIYDGPSTSSPLL---G 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442631782 2406 R---TKTSILFTLNTNAATIRFVAvQNVNNYRGFKIRYE 2441
Cdd:cd00041    75 RfcgSTLPPPIISSGNSLTVRFRS-DSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 857-963 1.02e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 70.13  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  857 CTGNFN-TNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNeNDTSYLDVYLSADQKRHIVK----S 931
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN-CSYDYLEIYDGPSTSSPLLGrfcgS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782  932 TDNLILLSHSNRASLVFH--GSGGGRGMRLEYNF 963
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRsdSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1411-1523 1.89e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 69.36  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1411 CGEHLRESG-GRFESPNAP--FSVDMDCVWIITASEGNQIRLllhevYFEAPQIECRDAESSLSVSAPSGYN-SSVVLFR 1486
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPnnYPNNLNCVWTIEAPPGYRIRL-----TFEDFDLESSPNCSYDYLEIYDGPStSSPLLGR 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782 1487 SCHEETqTQTFTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:cd00041    76 FCGSTL-PPPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2810-2911 7.60e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 67.44  E-value: 7.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2810 SPPVTISS----KNYLESKQRIWEFVTNDGLSLRLHFLErIFIVSSPNCSTDRLTVerYDQTTEEYIEVTSLCGRQAAND 2885
Cdd:cd00041     8 STSGTISSpnypNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEI--YDGPSTSSPLLGRFCGSTLPPP 84

                          90       100
                  ....*....|....*....|....*.
gi 442631782 2886 ILVPSARMRVIFQTNSNITGDGFSFQ 2911
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVTGRGFKAT 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3499-3607 5.31e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 65.13  E-value: 5.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 3499 CGGDLavGGSVGSYLENPSY--EGRNSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICG 3576
Cdd:cd00041     1 CGGTL--TASTSGTISSPNYpnNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCG 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442631782 3577 SRIPDMFTIAKNNVIIVAKKSQNFDGLGFRM 3607
Cdd:cd00041    79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKA 109
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 192-233 9.32e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 61.88  E-value: 9.32e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 442631782  192 DVNECftlagTDLDGCLNNGQCINTPGSYRCVCRNGFTGTHC 233
Cdd:cd00054     1 DIDEC-----ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1185-1293 1.14e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 63.97  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1185 CGGKLSSSM-GTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSND---NRICSG-QLTLYDGPTTASNPIVIRCNGT 1259
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDlesSPNCSYdYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782 1260 IAKPLQSTGNRVLVRYdVGHDAPDGTDFMLNYQT 1293
Cdd:cd00041    81 LPPPIISSGNSLTVRF-RSDSSVTGRGFKATYSA 113
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-190 9.86e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 56.11  E-value: 9.86e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  156 NECLS-NPCKNGGTCHDAYKGFQCECPAGWQGDSCE 190
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 427-455 7.59e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.84  E-value: 7.59e-08
                           10        20
                   ....*....|....*....|....*....
gi 442631782   427 CDQHPCQNNGTCVQNGRGTTCICQPGYSG 455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
cubilin_NTD super family cl41678
N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, ...
 38-141 2.00e-07

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, intestinal intrinsic factor receptor, intrinsic factor-cobalamin receptor, or intrinsic factor-vitamin B12 receptor) is an endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It acts together with the 45-kDa transmembrane protein amnionless (AMN) to mediate endocytosis of the cobalamin (vitamin B12) binding intrinsic factor (CBLIF)-cobalamin complex. This model corresponds to the N-terminal domain of cubilin, which is responsible for the interaction with AMN. The cubilin interface with AMN is formed by the N-terminal strands of three cubilin chains.


The actual alignment was detected with superfamily member cd22201:

Pssm-ID: 412063  Cd Length: 129  Bit Score: 52.33  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   38 SNDNLLLEPAWDRNVSLRLMGESAtVTINDVDMMTVLR----RRQRIIADRQAARREP-LKVDAVRDMFHDVELKMTRIQ 112
Cdd:cd22201    19 EDGHLIFEAAYDKNISFRTSGNGR-ININDEDLLELLQqaknNKSDIENLKQSELPTFeQQLSELVGGPQGLLRRLALLE 97

                          90       100
                  ....*....|....*....|....*....
gi 442631782  113 RRIFSARNSTKRsglNQRILRRQLQRVER 141
Cdd:cd22201    98 NRTSGLSSTLNN---NIRRLRRRLRRLER 123
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-328 4.41e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 4.41e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 442631782    290 DVDECEPRvNPCHD--ECINLPGSFRCgACPTGYTgDGRFC 328
Cdd:smart00179    1 DIDECASG-NPCQNggTCVNTVGSYRC-ECPPGYT-DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
330-374 2.10e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 442631782    330 DIDECASedNGGCslQPRVTCTNTEGSHRCgRCPAGWTgDGRTCT 374
Cdd:smart00179    1 DIDECAS--GNPC--QNGGTCVNTVGSYRC-ECPPGYT-DGRNCE 39
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2688-2782 8.57e-06

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member cd00041:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 113  Bit Score: 47.41  E-value: 8.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2688 CGGRLQAAEGVTIESPDLlttLNDAYGEVECLWTLSNSNGYVLEGNVT-----LTDRCDREYIVIFSGQSE----VGRIC 2758
Cdd:cd00041     1 CGGTLTASTSGTISSPNY---PNNYPNNLNCVWTIEAPPGYRIRLTFEdfdleSSPNCSYDYLEIYDGPSTssplLGRFC 77

                          90       100
                  ....*....|....*....|....
gi 442631782 2759 RGMAMNSTLLERPFSTILYHSESR 2782
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSS 101
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 462-496 1.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  462 DAC-HPSPCLNGGTCRLLPDAkYQCVCPRGYTGTTC 496
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3169-3249 1.08e-04

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member smart00042:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 102  Bit Score: 43.92  E-value: 1.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3169 NISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTcSYLEIHDSKDVEGQNLGRYYGGTNGNepsnrtKVFSSFSDMS 3248
Cdd:smart00042   11 SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEY-DYVEIYDGPSASSPLLGRFCGSEAPP------PVISSSSNSL 83


                    .
gi 442631782   3249 F 3249
Cdd:smart00042   84 T 84
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1066-1179 1.25e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 135.23  E-value: 1.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1066 CGGTFTA-RFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYC 1144
Cdd:cd00041     1 CGGTLTAsTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLE---SSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442631782 1145 GNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQ 1179
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
1066-1174 2.14e-35

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 131.65  E-value: 2.14e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1066 CGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYCG 1145
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELE---DHDECGYDYVEIRDGPSASSPLLGRFCG 77

                           90       100
                   ....*....|....*....|....*....
gi 442631782  1146 NEIPSRIPSFGNVLHLKFKSDDSMEEKGF 1174
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGF 106
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1075-1178 3.81e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 116.34  E-value: 3.81e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1075 GYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSR-IP 1153
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLE---SSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvIS 77

                            90       100
                    ....*....|....*....|....*
gi 442631782   1154 SFGNVLHLKFKSDDSMEEKGFLLSW 1178
Cdd:smart00042   78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1754-1862 8.09e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.97  E-value: 8.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1754 CGGNITSA-SGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRS--SVQGPLLALYCDKN 1830
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDgpSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442631782 1831 LPETPLVVHSELWIKFRSRPGNTAGGFRFRWT 1862
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
1754-1858 3.74e-28

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 111.23  E-value: 3.74e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1754 CGGNITSASGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRSSVQG--PLLALYCDKNL 1831
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSAssPLLGRFCGSGI 80

                           90       100
                   ....*....|....*....|....*..
gi 442631782  1832 PETPLVVHSELWIKFRSRPGNTAGGFR 1858
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFK 107
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 624-738 6.49e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 6.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  624 CGETInlTSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEasagNCSQDSLIVYDSD----RQLL 699
Cdd:cd00041     1 CGGTL--TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSP----NCSYDYLEIYDGPstssPLLG 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442631782  700 RACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEV 738
Cdd:cd00041    75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1763-1861 3.59e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.08  E-value: 3.59e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1763 GSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIR--SSVQGPLLALYCDKNLPETPLVVHS 1840
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYdgPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 442631782   1841 -ELWIKFRSRPGNTAGGFRFRW 1861
Cdd:smart00042   81 nSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3029-3143 5.54e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.41  E-value: 5.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 3029 CGGNYSTSF--TLRPPQNEDSsvYAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRtGLLC 3106
Cdd:cd00041     1 CGGTLTASTsgTISSPNYPNN--YPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLL-GRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782 3107 GNvTNPETIIVNSNEALIVLTTDSSNSYRGFLASVRF 3143
Cdd:cd00041    78 GS-TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 503-619 6.29e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.02  E-value: 6.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  503 CGVTIRGP-SGQLHYP--PNtadgDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRF 579
Cdd:cd00041     1 CGGTLTAStSGTISSPnyPN----NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 442631782  580 CGSRLPmtnGSVITTQEQVFFWFRSDNQTQGKGFHVIWNS 619
Cdd:cd00041    77 CGSTLP---PPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 3050-3140 3.97e-21

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 90.91  E-value: 3.97e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3050 YAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSeEQRTGLLCGNVTNPETIIVNSNEALIVLTTD 3129
Cdd:smart00042   12 YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSAS-SPLLGRFCGSEAPPPVISSSSNSLTLTFVSD 90

                            90
                    ....*....|.
gi 442631782   3130 SSNSYRGFLAS 3140
Cdd:smart00042   91 SSVQKRGFSAR 101
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1303-1406 1.10e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1303 QGAIETPNFPENYPPGQDCEWDIRAGGRKnHLQLIFSHLSVEkFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITT 1382
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGY-RIRLTFEDFDLE-SSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIIS 87

                          90       100
                  ....*....|....*....|....
gi 442631782 1383 VGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:cd00041    88 SGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 515-617 2.75e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 85.52  E-value: 2.75e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    515 HYPPNtadgdYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPmtnGSVITT 594
Cdd:smart00042    7 NYPQS-----YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAP---PPVISS 78

                            90       100
                    ....*....|....*....|....
gi 442631782    595 Q-EQVFFWFRSDNQTQGKGFHVIW 617
Cdd:smart00042   79 SsNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2210-2321 3.85e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 3.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2210 CNGEIQLNqqaPNYTIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEQFELSARHCDKENVEFFDGATKLARLLLRTC 2289
Cdd:cd00041     1 CGGTLTAS---TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 442631782 2290 -RKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLN 2321
Cdd:cd00041    78 gSTLPPPIISSGNSLTVRFRSDSSVTGRGFKAT 110
CUB pfam00431
CUB domain;
503-614 2.73e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 82.73  E-value: 2.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   503 CGVTIRGPSGQLHYP--PNtadgDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFC 580
Cdd:pfam00431    1 CGGVLTDSSGSISSPnyPN----PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 442631782   581 GSRLPMTngsVITTQEQVFFWFRSDNQTQGKGFH 614
Cdd:pfam00431   77 GSGIPED---IVSSSNQMTIKFVSDASVQKRGFK 107
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1530-1648 3.71e-18

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 82.85  E-value: 3.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1530 CGGYISAS-SGVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEI 1608
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPN--------NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 442631782 1609 fLEKTCGEDSPMIRIVHGRKLRVRFKSQA-GTWGRFIMYFE 1648
Cdd:cd00041    73 -LGRFCGSTLPPPIISSGNSLTVRFRSDSsVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1979-2091 5.52e-18

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 82.08  E-value: 5.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1979 CTKELTLSHHGDIelSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIQSSRDlIKWKNELHA 2058
Cdd:cd00041     1 CGGTLTASTSGTI--SSPNYPNNYPNNLNCVWTIEAP-PGYRIRLTFEDFDLESSPNCSYDYLEIYDGPS-TSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782 2059 CKASQIAPVH-GTPYLRLQFRSDVSINGTGFRAK 2091
Cdd:cd00041    77 CGSTLPPPIIsSGNSLTVRFRSDSSVTGRGFKAT 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1304-1406 1.91e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.13  E-value: 1.91e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1304 GAIETPNFPENYPPGQDCEWDIRAGGRKnHLQLIFSHLSVEKFSSiCLNDYVSLVDMLDDQTLSEQHLCTNDGLEP-ITT 1382
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGY-RIELQFTDFDLESSDN-CEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISS 78

                            90       100
                    ....*....|....*....|....
gi 442631782   1383 VGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:smart00042   79 SSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
3029-3140 1.94e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 80.42  E-value: 1.94e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  3029 CGGNYSTsftlrPPQNEDS----SVYAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRtGL 3104
Cdd:pfam00431    1 CGGVLTD-----SSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLL-GR 74

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 442631782  3105 LCGNvTNPETIIVNSNEALIVLTTDSSNSYRGFLAS 3140
Cdd:pfam00431   75 FCGS-GIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 636-736 2.93e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 79.74  E-value: 2.93e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    636 GVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEasagNCSQDSLIVYDSD----RQLLRACQSIQPPPVY 711
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSD----NCEYDYVEIYDGPsassPLLGRFCGSEAPPPVI 76

                            90       100
                    ....*....|....*....|....*.
gi 442631782    712 SS-SNSLRLDFHTDAIRSDSSFQMHY 736
Cdd:smart00042   77 SSsSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 2224-2321 1.93e-16

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 77.43  E-value: 1.93e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   2224 TIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEqFEL-SARHCDKENVEFFDGATKLARLLLRTC--RKPQNTVRTTG 2300
Cdd:smart00042    2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLeSSDNCEYDYVEIYDGPSASSPLLGRFCgsEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|.
gi 442631782   2301 NLLLVHYQSQLNEPTGGFRLN 2321
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSAR 101
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 745-854 1.61e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 75.14  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  745 CGGVYTESR-GRIS------GYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSh 817
Cdd:cd00041     1 CGGTLTASTsGTISspnypnNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782  818 eeSELEPIISIGNVILVRYEYALSGVRlsKSFDLTYT 854
Cdd:cd00041    80 --TLPPPIISSGNSLTVRFRSDSSVTG--RGFKATYS 112
CUB pfam00431
CUB domain;
1295-1406 2.43e-15

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 74.64  E-value: 2.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1295 CRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAggRKNH-LQLIFSHLSVEKfSSICLNDYVSLVDMLDDQTLSEQHLCT 1373
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRA--PPGFrVKLTFQDFELED-HDECGYDYVEIRDGPSASSPLLGRFCG 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 442631782  1374 NDGLEPITTVGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2327-2441 9.79e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.83  E-value: 9.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2327 CGGQFSASA-GFISSENYPhlGGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGtSSDRLEIVDYEDRTQKLMvldG 2405
Cdd:cd00041     1 CGGTLTASTsGTISSPNYP--NNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNC-SYDYLEIYDGPSTSSPLL---G 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442631782 2406 R---TKTSILFTLNTNAATIRFVAvQNVNNYRGFKIRYE 2441
Cdd:cd00041    75 RfcgSTLPPPIISSGNSLTVRFRS-DSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
624-736 1.23e-14

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 72.33  E-value: 1.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   624 CGETInltSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEAsagnCSQDSLIVYD---SDRQLL- 699
Cdd:pfam00431    1 CGGVL---TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDE----CGYDYVEIRDgpsASSPLLg 73

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 442631782   700 RACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHY 736
Cdd:pfam00431   74 RFCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 857-963 1.02e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 70.13  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  857 CTGNFN-TNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNeNDTSYLDVYLSADQKRHIVK----S 931
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN-CSYDYLEIYDGPSTSSPLLGrfcgS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782  932 TDNLILLSHSNRASLVFH--GSGGGRGMRLEYNF 963
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRsdSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
745-853 1.14e-13

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 69.63  E-value: 1.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   745 CGGVYTESRGRIS------GYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSHE 818
Cdd:pfam00431    1 CGGVLTDSSGSISspnypnPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 442631782   819 EselEPIISIGNVILVRYEYALSGVRlsKSFDLTY 853
Cdd:pfam00431   81 P---EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1411-1523 1.89e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 69.36  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1411 CGEHLRESG-GRFESPNAP--FSVDMDCVWIITASEGNQIRLllhevYFEAPQIECRDAESSLSVSAPSGYN-SSVVLFR 1486
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPnnYPNNLNCVWTIEAPPGYRIRL-----TFEDFDLESSPNCSYDYLEIYDGPStSSPLLGR 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782 1487 SCHEETqTQTFTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:cd00041    76 FCGSTL-PPPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB pfam00431
CUB domain;
2210-2321 5.90e-13

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 67.71  E-value: 5.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  2210 CNGEIQlnqqAPNYTIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEqFEL-SARHCDKENVEFFDGATKLARLLLRT 2288
Cdd:pfam00431    1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELeDHDECGYDYVEIRDGPSASSPLLGRF 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 442631782  2289 C-RKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLN 2321
Cdd:pfam00431   76 CgSGIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2810-2911 7.60e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 67.44  E-value: 7.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2810 SPPVTISS----KNYLESKQRIWEFVTNDGLSLRLHFLErIFIVSSPNCSTDRLTVerYDQTTEEYIEVTSLCGRQAAND 2885
Cdd:cd00041     8 STSGTISSpnypNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEI--YDGPSTSSPLLGRFCGSTLPPP 84

                          90       100
                  ....*....|....*....|....*.
gi 442631782 2886 ILVPSARMRVIFQTNSNITGDGFSFQ 2911
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVTGRGFKAT 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3499-3607 5.31e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 65.13  E-value: 5.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 3499 CGGDLavGGSVGSYLENPSY--EGRNSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICG 3576
Cdd:cd00041     1 CGGTL--TASTSGTISSPNYpnNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCG 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442631782 3577 SRIPDMFTIAKNNVIIVAKKSQNFDGLGFRM 3607
Cdd:cd00041    79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKA 109
CUB pfam00431
CUB domain;
1530-1638 5.46e-12

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 65.01  E-value: 5.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1530 CGGYISASSGVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKlEPDNKEIF 1609
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPN--------PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRD-GPSASSPL 71

                           90       100
                   ....*....|....*....|....*....
gi 442631782  1610 LEKTCGEDSPMIRIVHGRKLRVRFKSQAG 1638
Cdd:pfam00431   72 LGRFCGSGIPEDIVSSSNQMTIKFVSDAS 100
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1992-2091 6.05e-12

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 64.72  E-value: 6.05e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1992 ELSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIqssRDLIKWKNELHA--CkASQIAPVH- 2068
Cdd:smart00042    2 TITSPNYPQSYPNNLDCVWTIRAP-PGYRIELQFTDFDLESSDNCEYDYVEI---YDGPSASSPLLGrfC-GSEAPPPVi 76

                            90       100
                    ....*....|....*....|....*
gi 442631782   2069 --GTPYLRLQFRSDVSINGTGFRAK 2091
Cdd:smart00042   77 ssSSNSLTLTFVSDSSVQKRGFSAR 101
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 192-233 9.32e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 61.88  E-value: 9.32e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 442631782  192 DVNECftlagTDLDGCLNNGQCINTPGSYRCVCRNGFTGTHC 233
Cdd:cd00054     1 DIDEC-----ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1185-1293 1.14e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 63.97  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1185 CGGKLSSSM-GTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSND---NRICSG-QLTLYDGPTTASNPIVIRCNGT 1259
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDlesSPNCSYdYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782 1260 IAKPLQSTGNRVLVRYdVGHDAPDGTDFMLNYQT 1293
Cdd:cd00041    81 LPPPIISSGNSLTVRF-RSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1420-1523 1.71e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 63.18  E-value: 1.71e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1420 GRFESPNAP--FSVDMDCVWIITASEGNQIRLllhevYFEAPQIECRDAESSLSVSAPSGY-NSSVVLFRSCHEETQTQT 1496
Cdd:smart00042    1 GTITSPNYPqsYPNNLDCVWTIRAPPGYRIEL-----QFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPV 75

                            90       100
                    ....*....|....*....|....*..
gi 442631782   1497 FTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:smart00042   76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 866-961 4.20e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 62.02  E-value: 4.20e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    866 GIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNEnDTSYLDVYLSADQKRHIV-----KSTDNLILLSH 940
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNC-EYDYVEIYDGPSASSPLLgrfcgSEAPPPVISSS 79

                            90       100
                    ....*....|....*....|...
gi 442631782    941 SNRASLVFH--GSGGGRGMRLEY 961
Cdd:smart00042   80 SNSLTLTFVsdSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
2327-2440 4.21e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 62.31  E-value: 4.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  2327 CGGQFSASAGFISSENYPHlgGYPKPSVCEYSILLPKNAFIRLNITDLHLpYDANGTSSDRLEIVD-YEDRTQKLMVLDG 2405
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPN--PYPPNKDCVWLIRAPPGFRVKLTFQDFEL-EDHDECGYDYVEIRDgPSASSPLLGRFCG 77

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 442631782  2406 RTKTSILFTlNTNAATIRFVAvQNVNNYRGFKIRY 2440
Cdd:pfam00431   78 SGIPEDIVS-SSNQMTIKFVS-DASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 2336-2440 5.85e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 61.64  E-value: 5.85e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   2336 GFISSENYPhlGGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGTsSDRLEIVD-YEDRTQKLMVLDGRTKTSILFT 2414
Cdd:smart00042    1 GTITSPNYP--QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCE-YDYVEIYDgPSASSPLLGRFCGSEAPPPVIS 77

                            90       100
                    ....*....|....*....|....*.
gi 442631782   2415 LNTNAATIRFVAvQNVNNYRGFKIRY 2440
Cdd:smart00042   78 SSSNSLTLTFVS-DSSVQKRGFSARY 102
EGF_CA smart00179
Calcium-binding EGF-like domain;
192-233 2.75e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.64  E-value: 2.75e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 442631782    192 DVNECftlagTDLDGCLNNGQCINTPGSYRCVCRNGFT-GTHC 233
Cdd:smart00179    1 DIDEC-----ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-190 9.86e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 56.11  E-value: 9.86e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  156 NECLS-NPCKNGGTCHDAYKGFQCECPAGWQGDSCE 190
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1539-1647 1.33e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 57.79  E-value: 1.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1539 GVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIfLEKTCG-ED 1617
Cdd:smart00042    1 GTITSPNYPQ--------SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPL-LGRFCGsEA 71

                            90       100       110
                    ....*....|....*....|....*....|.
gi 442631782   1618 SPMIRIVHGRKLRVRFKSQAGTWGR-FIMYF 1647
Cdd:smart00042   72 PPPVISSSSNSLTLTFVSDSSVQKRgFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 757-853 3.59e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 56.63  E-value: 3.59e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    757 SGYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSheESELEPIISIGNVILVRY 836
Cdd:smart00042   10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGS--EAPPPVISSSSNSLTLTF 87

                            90
                    ....*....|....*..
gi 442631782    837 EYALSGVRlsKSFDLTY 853
Cdd:smart00042   88 VSDSSVQK--RGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 3512-3607 4.45e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 56.24  E-value: 4.45e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3512 YLENPSYEGR--NSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICGSRIP-DMFTIAKN 3588
Cdd:smart00042    2 TITSPNYPQSypNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPpPVISSSSN 81

                            90
                    ....*....|....*....
gi 442631782   3589 NVIIVAKKSQNFDGLGFRM 3607
Cdd:smart00042   82 SLTLTFVSDSSVQKRGFSA 100
CUB pfam00431
CUB domain;
1411-1523 6.85e-09

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 56.15  E-value: 6.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1411 CGEHLRESGGRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYFEAPQ------IECRDAESSlsvsapsgynSSV 1482
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPnpYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgydyVEIRDGPSA----------SSP 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 442631782  1483 VLFRSCHEETQTqTFTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:pfam00431   71 LLGRFCGSGIPE-DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
1992-2091 1.05e-08

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 55.76  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1992 ELSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIQSSRDLikwKNELHA--CKASQIAPVHG 2069
Cdd:pfam00431   11 SISSPNYPNPYPPNKDCVWLIRAP-PGFRVKLTFQDFELEDHDECGYDYVEIRDGPSA---SSPLLGrfCGSGIPEDIVS 86

                           90       100
                   ....*....|....*....|...
gi 442631782  2070 T-PYLRLQFRSDVSINGTGFRAK 2091
Cdd:pfam00431   87 SsNQMTIKFVSDASVQKRGFKAT 109
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 427-455 7.59e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.84  E-value: 7.59e-08
                           10        20
                   ....*....|....*....|....*....
gi 442631782   427 CDQHPCQNNGTCVQNGRGTTCICQPGYSG 455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-190 8.59e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 8.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 442631782    156 NECLS-NPCKNGGTCHDAYKGFQCECPAGWQ-GDSCE 190
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CUB pfam00431
CUB domain;
3499-3606 1.87e-07

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 51.91  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  3499 CGGDLAvgGSVGsYLENPSY--EGRNSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICG 3576
Cdd:pfam00431    1 CGGVLT--DSSG-SISSPNYpnPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCG 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 442631782  3577 SRIPDMFTIAKNNVIIVAKKSQNFDGLGFR 3606
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFK 107
cubilin_NTD cd22201
N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, ...
 38-141 2.00e-07

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, intestinal intrinsic factor receptor, intrinsic factor-cobalamin receptor, or intrinsic factor-vitamin B12 receptor) is an endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It acts together with the 45-kDa transmembrane protein amnionless (AMN) to mediate endocytosis of the cobalamin (vitamin B12) binding intrinsic factor (CBLIF)-cobalamin complex. This model corresponds to the N-terminal domain of cubilin, which is responsible for the interaction with AMN. The cubilin interface with AMN is formed by the N-terminal strands of three cubilin chains.


Pssm-ID: 412063  Cd Length: 129  Bit Score: 52.33  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   38 SNDNLLLEPAWDRNVSLRLMGESAtVTINDVDMMTVLR----RRQRIIADRQAARREP-LKVDAVRDMFHDVELKMTRIQ 112
Cdd:cd22201    19 EDGHLIFEAAYDKNISFRTSGNGR-ININDEDLLELLQqaknNKSDIENLKQSELPTFeQQLSELVGGPQGLLRRLALLE 97

                          90       100
                  ....*....|....*....|....*....
gi 442631782  113 RRIFSARNSTKRsglNQRILRRQLQRVER 141
Cdd:cd22201    98 NRTSGLSSTLNN---NIRRLRRRLRRLER 123
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-328 4.41e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 4.41e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 442631782    290 DVDECEPRvNPCHD--ECINLPGSFRCgACPTGYTgDGRFC 328
Cdd:smart00179    1 DIDECASG-NPCQNggTCVNTVGSYRC-ECPPGYT-DGRNC 38
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 2814-2909 1.05e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 49.70  E-value: 1.05e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   2814 TISS----KNYLESKQRIWEFVTNDGLSLRLHFLErIFIVSSPNCSTDRLTVerYDQTTEEYIEVTSLCGRQAANDILV- 2888
Cdd:smart00042    2 TITSpnypQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDNCEYDYVEI--YDGPSASSPLLGRFCGSEAPPPVISs 78

                            90       100
                    ....*....|....*....|.
gi 442631782   2889 PSARMRVIFQTNSNITGDGFS 2909
Cdd:smart00042   79 SSNSLTLTFVSDSSVQKRGFS 99
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 158-187 1.24e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.38  E-value: 1.24e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 442631782   158 CLSNPCKNGGTCHDAYKGFQCECPAGWQGD 187
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
CUB pfam00431
CUB domain;
2814-2909 1.35e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 49.60  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  2814 TISS----KNYLESKQRIWEFVTNDGLSLRLHFLEriF-IVSSPNCSTDrlTVERYDQTTEEYIEVTSLCGRQAANDILV 2888
Cdd:pfam00431   11 SISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQD--FeLEDHDECGYD--YVEIRDGPSASSPLLGRFCGSGIPEDIVS 86

                           90       100
                   ....*....|....*....|.
gi 442631782  2889 PSARMRVIFQTNSNITGDGFS 2909
Cdd:pfam00431   87 SSNQMTIKFVSDASVQKRGFK 107
EGF_CA smart00179
Calcium-binding EGF-like domain;
330-374 2.10e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 442631782    330 DIDECASedNGGCslQPRVTCTNTEGSHRCgRCPAGWTgDGRTCT 374
Cdd:smart00179    1 DIDECAS--GNPC--QNGGTCVNTVGSYRC-ECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 290-324 2.30e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442631782  290 DVDECEPRvNPCHD--ECINLPGSFRCgACPTGYTGD 324
Cdd:cd00054     1 DIDECASG-NPCQNggTCVNTVGSYRC-SCPPGYTGR 35
CUB pfam00431
CUB domain;
857-961 2.67e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 48.83  E-value: 2.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   857 CTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTaNNENDTSYLDVY--LSADQKRH--IVKST 932
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELED-HDECGYDYVEIRdgPSASSPLLgrFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 442631782   933 DNLILLSHSNRASLVFH--GSGGGRGMRLEY 961
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVsdASVQKRGFKATY 110
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 294-328 7.05e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 7.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 442631782   294 CEPRVNPCHD--ECINLPGSFRCgACPTGYTGDGRFC 328
Cdd:pfam12947    1 CSDNNGGCHPnaTCTNTGGSFTC-TCNDGYTGDGVTC 36
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2688-2782 8.57e-06

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 47.41  E-value: 8.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2688 CGGRLQAAEGVTIESPDLlttLNDAYGEVECLWTLSNSNGYVLEGNVT-----LTDRCDREYIVIFSGQSE----VGRIC 2758
Cdd:cd00041     1 CGGTLTASTSGTISSPNY---PNNYPNNLNCVWTIEAPPGYRIRLTFEdfdleSSPNCSYDYLEIYDGPSTssplLGRFC 77

                          90       100
                  ....*....|....*....|....
gi 442631782 2759 RGMAMNSTLLERPFSTILYHSESR 2782
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSS 101
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 462-496 1.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  462 DAC-HPSPCLNGGTCRLLPDAkYQCVCPRGYTGTTC 496
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 464-493 1.63e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 1.63e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 442631782   464 CHPSPCLNGGTCRLLPDAkYQCVCPRGYTG 493
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 330-374 4.67e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 4.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 442631782  330 DIDECASedNGGCslQPRVTCTNTEGSHRCgRCPAGWTgdGRTCT 374
Cdd:cd00054     1 DIDECAS--GNPC--QNGGTCVNTVGSYRC-SCPPGYT--GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 427-458 6.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 6.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442631782  427 CDQ-HPCQNNGTCVqNGRGT-TCICQPGYSGVVC 458
Cdd:cd00054     5 CASgNPCQNGGTCV-NTVGSyRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
192-227 6.37e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 6.37e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 442631782   192 DVNECFTLAgtdlDGCLNNGQCINTPGSYRCVCRNG 227
Cdd:pfam07645    1 DVDECATGT----HNCPANTVCVNTIGSFECRCPDG 32
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 3169-3249 1.08e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 43.92  E-value: 1.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3169 NISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTcSYLEIHDSKDVEGQNLGRYYGGTNGNepsnrtKVFSSFSDMS 3248
Cdd:smart00042   11 SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEY-DYVEIYDGPSASSPLLGRFCGSEAPP------PVISSSSNSL 83


                    .
gi 442631782   3249 F 3249
Cdd:smart00042   84 T 84
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3171-3225 1.04e-03

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 41.24  E-value: 1.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442631782 3171 SESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTcSYLEIHDSKDVEGQNLGRY 3225
Cdd:cd00041    23 PNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSY-DYLEIYDGPSTSSPLLGRF 76
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 336-373 1.66e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 1.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442631782   336 SEDNGGCSlQprvTCTNTEGSHRCgRCPAGWT--GDGRTC 373
Cdd:pfam14670    2 SVNNGGCS-H---LCLNTPGGYTC-SCPEGYElqDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
466-496 3.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 3.29e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 442631782    466 PSPCLNGGTCRLLPDAkYQCVCPRGYT-GTTC 496
Cdd:smart00179    8 GNPCQNGGTCVNTVGS-YRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
430-458 9.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 9.43e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 442631782    430 HPCQNNGTCVqNGRGT-TCICQPGYS-GVVC 458
Cdd:smart00179    9 NPCQNGGTCV-NTVGSyRCECPPGYTdGRNC 38
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1066-1179 1.25e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 135.23  E-value: 1.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1066 CGGTFTA-RFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYC 1144
Cdd:cd00041     1 CGGTLTAsTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLE---SSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442631782 1145 GNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQ 1179
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
1066-1174 2.14e-35

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 131.65  E-value: 2.14e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1066 CGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYCG 1145
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELE---DHDECGYDYVEIRDGPSASSPLLGRFCG 77

                           90       100
                   ....*....|....*....|....*....
gi 442631782  1146 NEIPSRIPSFGNVLHLKFKSDDSMEEKGF 1174
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGF 106
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1075-1178 3.81e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 116.34  E-value: 3.81e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1075 GYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEeeySSTGCWTDWLEIRNGDSESSPLIGRYCGNEIPSR-IP 1153
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLE---SSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvIS 77

                            90       100
                    ....*....|....*....|....*
gi 442631782   1154 SFGNVLHLKFKSDDSMEEKGFLLSW 1178
Cdd:smart00042   78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1754-1862 8.09e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.97  E-value: 8.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1754 CGGNITSA-SGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRS--SVQGPLLALYCDKN 1830
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDgpSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442631782 1831 LPETPLVVHSELWIKFRSRPGNTAGGFRFRWT 1862
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
1754-1858 3.74e-28

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 111.23  E-value: 3.74e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1754 CGGNITSASGSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRSSVQG--PLLALYCDKNL 1831
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSAssPLLGRFCGSGI 80

                           90       100
                   ....*....|....*....|....*..
gi 442631782  1832 PETPLVVHSELWIKFRSRPGNTAGGFR 1858
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFK 107
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 624-738 6.49e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 6.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  624 CGETInlTSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEasagNCSQDSLIVYDSD----RQLL 699
Cdd:cd00041     1 CGGTL--TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSP----NCSYDYLEIYDGPstssPLLG 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442631782  700 RACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEV 738
Cdd:cd00041    75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1763-1861 3.59e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.08  E-value: 3.59e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1763 GSLSSPNYPDSYPANIECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIR--SSVQGPLLALYCDKNLPETPLVVHS 1840
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYdgPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 442631782   1841 -ELWIKFRSRPGNTAGGFRFRW 1861
Cdd:smart00042   81 nSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3029-3143 5.54e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.41  E-value: 5.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 3029 CGGNYSTSF--TLRPPQNEDSsvYAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRtGLLC 3106
Cdd:cd00041     1 CGGTLTASTsgTISSPNYPNN--YPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLL-GRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782 3107 GNvTNPETIIVNSNEALIVLTTDSSNSYRGFLASVRF 3143
Cdd:cd00041    78 GS-TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 503-619 6.29e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.02  E-value: 6.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  503 CGVTIRGP-SGQLHYP--PNtadgDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRF 579
Cdd:cd00041     1 CGGTLTAStSGTISSPnyPN----NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 442631782  580 CGSRLPmtnGSVITTQEQVFFWFRSDNQTQGKGFHVIWNS 619
Cdd:cd00041    77 CGSTLP---PPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 3050-3140 3.97e-21

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 90.91  E-value: 3.97e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3050 YAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSeEQRTGLLCGNVTNPETIIVNSNEALIVLTTD 3129
Cdd:smart00042   12 YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSAS-SPLLGRFCGSEAPPPVISSSSNSLTLTFVSD 90

                            90
                    ....*....|.
gi 442631782   3130 SSNSYRGFLAS 3140
Cdd:smart00042   91 SSVQKRGFSAR 101
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1303-1406 1.10e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1303 QGAIETPNFPENYPPGQDCEWDIRAGGRKnHLQLIFSHLSVEkFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITT 1382
Cdd:cd00041    10 SGTISSPNYPNNYPNNLNCVWTIEAPPGY-RIRLTFEDFDLE-SSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIIS 87

                          90       100
                  ....*....|....*....|....
gi 442631782 1383 VGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:cd00041    88 SGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 515-617 2.75e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 85.52  E-value: 2.75e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    515 HYPPNtadgdYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPmtnGSVITT 594
Cdd:smart00042    7 NYPQS-----YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAP---PPVISS 78

                            90       100
                    ....*....|....*....|....
gi 442631782    595 Q-EQVFFWFRSDNQTQGKGFHVIW 617
Cdd:smart00042   79 SsNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2210-2321 3.85e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 3.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2210 CNGEIQLNqqaPNYTIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEQFELSARHCDKENVEFFDGATKLARLLLRTC 2289
Cdd:cd00041     1 CGGTLTAS---TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 442631782 2290 -RKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLN 2321
Cdd:cd00041    78 gSTLPPPIISSGNSLTVRFRSDSSVTGRGFKAT 110
CUB pfam00431
CUB domain;
503-614 2.73e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 82.73  E-value: 2.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   503 CGVTIRGPSGQLHYP--PNtadgDYQADERCPFIIRTNRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFC 580
Cdd:pfam00431    1 CGGVLTDSSGSISSPnyPN----PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 442631782   581 GSRLPMTngsVITTQEQVFFWFRSDNQTQGKGFH 614
Cdd:pfam00431   77 GSGIPED---IVSSSNQMTIKFVSDASVQKRGFK 107
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1530-1648 3.71e-18

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 82.85  E-value: 3.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1530 CGGYISAS-SGVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEI 1608
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPN--------NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 442631782 1609 fLEKTCGEDSPMIRIVHGRKLRVRFKSQA-GTWGRFIMYFE 1648
Cdd:cd00041    73 -LGRFCGSTLPPPIISSGNSLTVRFRSDSsVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1979-2091 5.52e-18

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 82.08  E-value: 5.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1979 CTKELTLSHHGDIelSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIQSSRDlIKWKNELHA 2058
Cdd:cd00041     1 CGGTLTASTSGTI--SSPNYPNNYPNNLNCVWTIEAP-PGYRIRLTFEDFDLESSPNCSYDYLEIYDGPS-TSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782 2059 CKASQIAPVH-GTPYLRLQFRSDVSINGTGFRAK 2091
Cdd:cd00041    77 CGSTLPPPIIsSGNSLTVRFRSDSSVTGRGFKAT 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1304-1406 1.91e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.13  E-value: 1.91e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1304 GAIETPNFPENYPPGQDCEWDIRAGGRKnHLQLIFSHLSVEKFSSiCLNDYVSLVDMLDDQTLSEQHLCTNDGLEP-ITT 1382
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGY-RIELQFTDFDLESSDN-CEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISS 78

                            90       100
                    ....*....|....*....|....
gi 442631782   1383 VGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:smart00042   79 SSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
3029-3140 1.94e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 80.42  E-value: 1.94e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  3029 CGGNYSTsftlrPPQNEDS----SVYAHNTLCEWRITAPPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRtGL 3104
Cdd:pfam00431    1 CGGVLTD-----SSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLL-GR 74

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 442631782  3105 LCGNvTNPETIIVNSNEALIVLTTDSSNSYRGFLAS 3140
Cdd:pfam00431   75 FCGS-GIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 636-736 2.93e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 79.74  E-value: 2.93e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    636 GVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEasagNCSQDSLIVYDSD----RQLLRACQSIQPPPVY 711
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSD----NCEYDYVEIYDGPsassPLLGRFCGSEAPPPVI 76

                            90       100
                    ....*....|....*....|....*.
gi 442631782    712 SS-SNSLRLDFHTDAIRSDSSFQMHY 736
Cdd:smart00042   77 SSsSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 2224-2321 1.93e-16

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 77.43  E-value: 1.93e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   2224 TIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEqFEL-SARHCDKENVEFFDGATKLARLLLRTC--RKPQNTVRTTG 2300
Cdd:smart00042    2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLeSSDNCEYDYVEIYDGPSASSPLLGRFCgsEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|.
gi 442631782   2301 NLLLVHYQSQLNEPTGGFRLN 2321
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSAR 101
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 745-854 1.61e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 75.14  E-value: 1.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  745 CGGVYTESR-GRIS------GYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSh 817
Cdd:cd00041     1 CGGTLTASTsGTISspnypnNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782  818 eeSELEPIISIGNVILVRYEYALSGVRlsKSFDLTYT 854
Cdd:cd00041    80 --TLPPPIISSGNSLTVRFRSDSSVTG--RGFKATYS 112
CUB pfam00431
CUB domain;
1295-1406 2.43e-15

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 74.64  E-value: 2.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1295 CRVRLEGLQGAIETPNFPENYPPGQDCEWDIRAggRKNH-LQLIFSHLSVEKfSSICLNDYVSLVDMLDDQTLSEQHLCT 1373
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRA--PPGFrVKLTFQDFELED-HDECGYDYVEIRDGPSASSPLLGRFCG 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 442631782  1374 NDGLEPITTVGNRLLLRFKSDSSVELQGFRAEY 1406
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2327-2441 9.79e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.83  E-value: 9.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2327 CGGQFSASA-GFISSENYPhlGGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGtSSDRLEIVDYEDRTQKLMvldG 2405
Cdd:cd00041     1 CGGTLTASTsGTISSPNYP--NNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNC-SYDYLEIYDGPSTSSPLL---G 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442631782 2406 R---TKTSILFTLNTNAATIRFVAvQNVNNYRGFKIRYE 2441
Cdd:cd00041    75 RfcgSTLPPPIISSGNSLTVRFRS-DSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
624-736 1.23e-14

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 72.33  E-value: 1.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   624 CGETInltSTQTGVLRSPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEAsagnCSQDSLIVYD---SDRQLL- 699
Cdd:pfam00431    1 CGGVL---TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDE----CGYDYVEIRDgpsASSPLLg 73

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 442631782   700 RACQSIQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHY 736
Cdd:pfam00431   74 RFCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 857-963 1.02e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 70.13  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  857 CTGNFN-TNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNeNDTSYLDVYLSADQKRHIVK----S 931
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN-CSYDYLEIYDGPSTSSPLLGrfcgS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782  932 TDNLILLSHSNRASLVFH--GSGGGRGMRLEYNF 963
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRsdSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
745-853 1.14e-13

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 69.63  E-value: 1.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   745 CGGVYTESRGRIS------GYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSHE 818
Cdd:pfam00431    1 CGGVLTDSSGSISspnypnPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 442631782   819 EselEPIISIGNVILVRYEYALSGVRlsKSFDLTY 853
Cdd:pfam00431   81 P---EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1411-1523 1.89e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 69.36  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1411 CGEHLRESG-GRFESPNAP--FSVDMDCVWIITASEGNQIRLllhevYFEAPQIECRDAESSLSVSAPSGYN-SSVVLFR 1486
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPnnYPNNLNCVWTIEAPPGYRIRL-----TFEDFDLESSPNCSYDYLEIYDGPStSSPLLGR 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442631782 1487 SCHEETqTQTFTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:cd00041    76 FCGSTL-PPPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB pfam00431
CUB domain;
2210-2321 5.90e-13

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 67.71  E-value: 5.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  2210 CNGEIQlnqqAPNYTIMSPGYPYLPHPHAECTWLVMAPPGETIAVDFDEqFEL-SARHCDKENVEFFDGATKLARLLLRT 2288
Cdd:pfam00431    1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELeDHDECGYDYVEIRDGPSASSPLLGRF 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 442631782  2289 C-RKPQNTVRTTGNLLLVHYQSQLNEPTGGFRLN 2321
Cdd:pfam00431   76 CgSGIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2810-2911 7.60e-13

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 67.44  E-value: 7.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2810 SPPVTISS----KNYLESKQRIWEFVTNDGLSLRLHFLErIFIVSSPNCSTDRLTVerYDQTTEEYIEVTSLCGRQAAND 2885
Cdd:cd00041     8 STSGTISSpnypNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEI--YDGPSTSSPLLGRFCGSTLPPP 84

                          90       100
                  ....*....|....*....|....*.
gi 442631782 2886 ILVPSARMRVIFQTNSNITGDGFSFQ 2911
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVTGRGFKAT 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3499-3607 5.31e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 65.13  E-value: 5.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 3499 CGGDLavGGSVGSYLENPSY--EGRNSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICG 3576
Cdd:cd00041     1 CGGTL--TASTSGTISSPNYpnNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCG 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442631782 3577 SRIPDMFTIAKNNVIIVAKKSQNFDGLGFRM 3607
Cdd:cd00041    79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKA 109
CUB pfam00431
CUB domain;
1530-1638 5.46e-12

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 65.01  E-value: 5.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1530 CGGYISASSGVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKlEPDNKEIF 1609
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPN--------PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRD-GPSASSPL 71

                           90       100
                   ....*....|....*....|....*....
gi 442631782  1610 LEKTCGEDSPMIRIVHGRKLRVRFKSQAG 1638
Cdd:pfam00431   72 LGRFCGSGIPEDIVSSSNQMTIKFVSDAS 100
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1992-2091 6.05e-12

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 64.72  E-value: 6.05e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1992 ELSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIqssRDLIKWKNELHA--CkASQIAPVH- 2068
Cdd:smart00042    2 TITSPNYPQSYPNNLDCVWTIRAP-PGYRIELQFTDFDLESSDNCEYDYVEI---YDGPSASSPLLGrfC-GSEAPPPVi 76

                            90       100
                    ....*....|....*....|....*
gi 442631782   2069 --GTPYLRLQFRSDVSINGTGFRAK 2091
Cdd:smart00042   77 ssSSNSLTLTFVSDSSVQKRGFSAR 101
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 192-233 9.32e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 61.88  E-value: 9.32e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 442631782  192 DVNECftlagTDLDGCLNNGQCINTPGSYRCVCRNGFTGTHC 233
Cdd:cd00054     1 DIDEC-----ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 1185-1293 1.14e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 63.97  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 1185 CGGKLSSSM-GTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSND---NRICSG-QLTLYDGPTTASNPIVIRCNGT 1259
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDlesSPNCSYdYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442631782 1260 IAKPLQSTGNRVLVRYdVGHDAPDGTDFMLNYQT 1293
Cdd:cd00041    81 LPPPIISSGNSLTVRF-RSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1420-1523 1.71e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 63.18  E-value: 1.71e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1420 GRFESPNAP--FSVDMDCVWIITASEGNQIRLllhevYFEAPQIECRDAESSLSVSAPSGY-NSSVVLFRSCHEETQTQT 1496
Cdd:smart00042    1 GTITSPNYPqsYPNNLDCVWTIRAPPGYRIEL-----QFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPV 75

                            90       100
                    ....*....|....*....|....*..
gi 442631782   1497 FTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:smart00042   76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 866-961 4.20e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 62.02  E-value: 4.20e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    866 GIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTANNEnDTSYLDVYLSADQKRHIV-----KSTDNLILLSH 940
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNC-EYDYVEIYDGPSASSPLLgrfcgSEAPPPVISSS 79

                            90       100
                    ....*....|....*....|...
gi 442631782    941 SNRASLVFH--GSGGGRGMRLEY 961
Cdd:smart00042   80 SNSLTLTFVsdSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
2327-2440 4.21e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 62.31  E-value: 4.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  2327 CGGQFSASAGFISSENYPHlgGYPKPSVCEYSILLPKNAFIRLNITDLHLpYDANGTSSDRLEIVD-YEDRTQKLMVLDG 2405
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPN--PYPPNKDCVWLIRAPPGFRVKLTFQDFEL-EDHDECGYDYVEIRDgPSASSPLLGRFCG 77

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 442631782  2406 RTKTSILFTlNTNAATIRFVAvQNVNNYRGFKIRY 2440
Cdd:pfam00431   78 SGIPEDIVS-SSNQMTIKFVS-DASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 2336-2440 5.85e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 61.64  E-value: 5.85e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   2336 GFISSENYPhlGGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGTsSDRLEIVD-YEDRTQKLMVLDGRTKTSILFT 2414
Cdd:smart00042    1 GTITSPNYP--QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCE-YDYVEIYDgPSASSPLLGRFCGSEAPPPVIS 77

                            90       100
                    ....*....|....*....|....*.
gi 442631782   2415 LNTNAATIRFVAvQNVNNYRGFKIRY 2440
Cdd:smart00042   78 SSSNSLTLTFVS-DSSVQKRGFSARY 102
EGF_CA smart00179
Calcium-binding EGF-like domain;
192-233 2.75e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.64  E-value: 2.75e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 442631782    192 DVNECftlagTDLDGCLNNGQCINTPGSYRCVCRNGFT-GTHC 233
Cdd:smart00179    1 DIDEC-----ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-190 9.86e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 56.11  E-value: 9.86e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  156 NECLS-NPCKNGGTCHDAYKGFQCECPAGWQGDSCE 190
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 1539-1647 1.33e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 57.79  E-value: 1.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   1539 GVLTTPGFHNhqdsknvaNYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIfLEKTCG-ED 1617
Cdd:smart00042    1 GTITSPNYPQ--------SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPL-LGRFCGsEA 71

                            90       100       110
                    ....*....|....*....|....*....|.
gi 442631782   1618 SPMIRIVHGRKLRVRFKSQAGTWGR-FIMYF 1647
Cdd:smart00042   72 PPPVISSSSNSLTLTFVSDSSVQKRgFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 757-853 3.59e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 56.63  E-value: 3.59e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782    757 SGYMNFEVCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSheESELEPIISIGNVILVRY 836
Cdd:smart00042   10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGS--EAPPPVISSSSNSLTLTF 87

                            90
                    ....*....|....*..
gi 442631782    837 EYALSGVRlsKSFDLTY 853
Cdd:smart00042   88 VSDSSVQK--RGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 3512-3607 4.45e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 56.24  E-value: 4.45e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3512 YLENPSYEGR--NSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICGSRIP-DMFTIAKN 3588
Cdd:smart00042    2 TITSPNYPQSypNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPpPVISSSSN 81

                            90
                    ....*....|....*....
gi 442631782   3589 NVIIVAKKSQNFDGLGFRM 3607
Cdd:smart00042   82 SLTLTFVSDSSVQKRGFSA 100
CUB pfam00431
CUB domain;
1411-1523 6.85e-09

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 56.15  E-value: 6.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1411 CGEHLRESGGRFESPNAP--FSVDMDCVWIITASEGNQIRLLLHEVYFEAPQ------IECRDAESSlsvsapsgynSSV 1482
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPnpYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgydyVEIRDGPSA----------SSP 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 442631782  1483 VLFRSCHEETQTqTFTSPGNELVIRFVSSSAPSRKYFKASF 1523
Cdd:pfam00431   71 LLGRFCGSGIPE-DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
1992-2091 1.05e-08

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 55.76  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  1992 ELSSPGYPHGYAPNLNCEWTIRSQfPSHHIYAHSIIVDLEDYPACSADYLSIQSSRDLikwKNELHA--CKASQIAPVHG 2069
Cdd:pfam00431   11 SISSPNYPNPYPPNKDCVWLIRAP-PGFRVKLTFQDFELEDHDECGYDYVEIRDGPSA---SSPLLGrfCGSGIPEDIVS 86

                           90       100
                   ....*....|....*....|...
gi 442631782  2070 T-PYLRLQFRSDVSINGTGFRAK 2091
Cdd:pfam00431   87 SsNQMTIKFVSDASVQKRGFKAT 109
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 427-455 7.59e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.84  E-value: 7.59e-08
                           10        20
                   ....*....|....*....|....*....
gi 442631782   427 CDQHPCQNNGTCVQNGRGTTCICQPGYSG 455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-190 8.59e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 8.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 442631782    156 NECLS-NPCKNGGTCHDAYKGFQCECPAGWQ-GDSCE 190
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CUB pfam00431
CUB domain;
3499-3606 1.87e-07

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 51.91  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  3499 CGGDLAvgGSVGsYLENPSY--EGRNSSLCTWKISVPAGGSLRFSFAEFNMGSESNCDLDNVRFYDSVVDDQRLVKAICG 3576
Cdd:pfam00431    1 CGGVLT--DSSG-SISSPNYpnPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCG 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 442631782  3577 SRIPDMFTIAKNNVIIVAKKSQNFDGLGFR 3606
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFK 107
cubilin_NTD cd22201
N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, ...
 38-141 2.00e-07

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, intestinal intrinsic factor receptor, intrinsic factor-cobalamin receptor, or intrinsic factor-vitamin B12 receptor) is an endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It acts together with the 45-kDa transmembrane protein amnionless (AMN) to mediate endocytosis of the cobalamin (vitamin B12) binding intrinsic factor (CBLIF)-cobalamin complex. This model corresponds to the N-terminal domain of cubilin, which is responsible for the interaction with AMN. The cubilin interface with AMN is formed by the N-terminal strands of three cubilin chains.


Pssm-ID: 412063  Cd Length: 129  Bit Score: 52.33  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   38 SNDNLLLEPAWDRNVSLRLMGESAtVTINDVDMMTVLR----RRQRIIADRQAARREP-LKVDAVRDMFHDVELKMTRIQ 112
Cdd:cd22201    19 EDGHLIFEAAYDKNISFRTSGNGR-ININDEDLLELLQqaknNKSDIENLKQSELPTFeQQLSELVGGPQGLLRRLALLE 97

                          90       100
                  ....*....|....*....|....*....
gi 442631782  113 RRIFSARNSTKRsglNQRILRRQLQRVER 141
Cdd:cd22201    98 NRTSGLSSTLNN---NIRRLRRRLRRLER 123
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-328 4.41e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 4.41e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 442631782    290 DVDECEPRvNPCHD--ECINLPGSFRCgACPTGYTgDGRFC 328
Cdd:smart00179    1 DIDECASG-NPCQNggTCVNTVGSYRC-ECPPGYT-DGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 205-233 5.87e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 48.24  E-value: 5.87e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 442631782  205 DGCLNNGQCINTPGSYRCVCRNGFTG-THC 233
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 2814-2909 1.05e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 49.70  E-value: 1.05e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   2814 TISS----KNYLESKQRIWEFVTNDGLSLRLHFLErIFIVSSPNCSTDRLTVerYDQTTEEYIEVTSLCGRQAANDILV- 2888
Cdd:smart00042    2 TITSpnypQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDNCEYDYVEI--YDGPSASSPLLGRFCGSEAPPPVISs 78

                            90       100
                    ....*....|....*....|.
gi 442631782   2889 PSARMRVIFQTNSNITGDGFS 2909
Cdd:smart00042   79 SSNSLTLTFVSDSSVQKRGFS 99
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 157-190 1.06e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 47.47  E-value: 1.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  157 EC-LSNPCKNGGTCHDAYKGFQCECPAGWQGD-SCE 190
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 158-187 1.24e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.38  E-value: 1.24e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 442631782   158 CLSNPCKNGGTCHDAYKGFQCECPAGWQGD 187
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
CUB pfam00431
CUB domain;
2814-2909 1.35e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 49.60  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782  2814 TISS----KNYLESKQRIWEFVTNDGLSLRLHFLEriF-IVSSPNCSTDrlTVERYDQTTEEYIEVTSLCGRQAANDILV 2888
Cdd:pfam00431   11 SISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQD--FeLEDHDECGYD--YVEIRDGPSASSPLLGRFCGSGIPEDIVS 86

                           90       100
                   ....*....|....*....|.
gi 442631782  2889 PSARMRVIFQTNSNITGDGFS 2909
Cdd:pfam00431   87 SSNQMTIKFVSDASVQKRGFK 107
EGF_CA smart00179
Calcium-binding EGF-like domain;
330-374 2.10e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 442631782    330 DIDECASedNGGCslQPRVTCTNTEGSHRCgRCPAGWTgDGRTCT 374
Cdd:smart00179    1 DIDECAS--GNPC--QNGGTCVNTVGSYRC-ECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 290-324 2.30e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 2.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442631782  290 DVDECEPRvNPCHD--ECINLPGSFRCgACPTGYTGD 324
Cdd:cd00054     1 DIDECASG-NPCQNggTCVNTVGSYRC-SCPPGYTGR 35
CUB pfam00431
CUB domain;
857-961 2.67e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 48.83  E-value: 2.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   857 CTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTAVRMRITDLSLGTaNNENDTSYLDVY--LSADQKRH--IVKST 932
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELED-HDECGYDYVEIRdgPSASSPLLgrFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 442631782   933 DNLILLSHSNRASLVFH--GSGGGRGMRLEY 961
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVsdASVQKRGFKATY 110
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 294-328 7.05e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 7.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 442631782   294 CEPRVNPCHD--ECINLPGSFRCgACPTGYTGDGRFC 328
Cdd:pfam12947    1 CSDNNGGCHPnaTCTNTGGSFTC-TCNDGYTGDGVTC 36
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 2688-2782 8.57e-06

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 47.41  E-value: 8.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782 2688 CGGRLQAAEGVTIESPDLlttLNDAYGEVECLWTLSNSNGYVLEGNVT-----LTDRCDREYIVIFSGQSE----VGRIC 2758
Cdd:cd00041     1 CGGTLTASTSGTISSPNY---PNNYPNNLNCVWTIEAPPGYRIRLTFEdfdleSSPNCSYDYLEIYDGPSTssplLGRFC 77

                          90       100
                  ....*....|....*....|....
gi 442631782 2759 RGMAMNSTLLERPFSTILYHSESR 2782
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSS 101
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 462-496 1.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  462 DAC-HPSPCLNGGTCRLLPDAkYQCVCPRGYTGTTC 496
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 464-493 1.63e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 1.63e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 442631782   464 CHPSPCLNGGTCRLLPDAkYQCVCPRGYTG 493
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 163-184 4.49e-05

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 42.71  E-value: 4.49e-05
                           10        20
                   ....*....|....*....|..
gi 442631782   163 CKNGGTCHDAYKGFQCECPAGW 184
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 330-374 4.67e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 4.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 442631782  330 DIDECASedNGGCslQPRVTCTNTEGSHRCgRCPAGWTgdGRTCT 374
Cdd:cd00054     1 DIDECAS--GNPC--QNGGTCVNTVGSYRC-SCPPGYT--GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 427-458 6.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 6.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442631782  427 CDQ-HPCQNNGTCVqNGRGT-TCICQPGYSGVVC 458
Cdd:cd00054     5 CASgNPCQNGGTCV-NTVGSyRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
192-227 6.37e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 6.37e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 442631782   192 DVNECFTLAgtdlDGCLNNGQCINTPGSYRCVCRNG 227
Cdd:pfam07645    1 DVDECATGT----HNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 426-455 8.16e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.08  E-value: 8.16e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442631782  426 PCDQ-HPCQNNGTCVQNGRGTTCICQPGYSG 455
Cdd:cd00053     1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 205-233 9.50e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 9.50e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442631782   205 DGCLNNGQCINTPGSYRCVCRNGFT--GTHC 233
Cdd:pfam12947    6 GGCHPNATCTNTGGSFTCTCNDGYTgdGVTC 36
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 3169-3249 1.08e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 43.92  E-value: 1.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631782   3169 NISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTcSYLEIHDSKDVEGQNLGRYYGGTNGNepsnrtKVFSSFSDMS 3248
Cdd:smart00042   11 SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEY-DYVEIYDGPSASSPLLGRFCGSEAPP------PVISSSSNSL 83


                    .
gi 442631782   3249 F 3249
Cdd:smart00042   84 T 84
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 203-230 1.39e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 1.39e-04
                           10        20
                   ....*....|....*....|....*...
gi 442631782   203 DLDGCLNNGQCINTPGSYRCVCRNGFTG 230
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF smart00181
Epidermal growth factor-like domain;
210-230 4.38e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 4.38e-04
                            10        20
                    ....*....|....*....|.
gi 442631782    210 NGQCINTPGSYRCVCRNGFTG 230
Cdd:smart00181   10 NGTCINTPGSYTCSCPPGYTG 30
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 3171-3225 1.04e-03

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 41.24  E-value: 1.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442631782 3171 SESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTcSYLEIHDSKDVEGQNLGRY 3225
Cdd:cd00041    23 PNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSY-DYLEIYDGPSTSSPLLGRF 76
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 432-453 1.34e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.47  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|..
gi 442631782   432 CQNNGTCVQNGRGTTCICQPGY 453
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 466-496 1.41e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442631782  466 PSPCLNGGTCRLLPDaKYQCVCPRGYTG-TTC 496
Cdd:cd00053     5 SNPCSNGGTCVNTPG-SYRCVCPPGYTGdRSC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 336-373 1.66e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 1.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442631782   336 SEDNGGCSlQprvTCTNTEGSHRCgRCPAGWT--GDGRTC 373
Cdd:pfam14670    2 SVNNGGCS-H---LCLNTPGGYTC-SCPEGYElqDDGRTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 293-326 1.86e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442631782  293 ECEPRvNPCHD--ECINLPGSFRCgACPTGYTGDGR 326
Cdd:cd00053     1 ECAAS-NPCSNggTCVNTPGSYRC-VCPPGYTGDRS 34
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 207-228 1.91e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.08  E-value: 1.91e-03
                           10        20
                   ....*....|....*....|..
gi 442631782   207 CLNNGQCINTPGSYRCVCRNGF 228
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF smart00181
Epidermal growth factor-like domain;
157-190 2.26e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 2.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 442631782    157 ECLS-NPCKNGgTCHDAYKGFQCECPAGWQGD-SCE 190
Cdd:smart00181    1 ECASgGPCSNG-TCINTPGSYTCSCPPGYTGDkRCE 35
EGF smart00181
Epidermal growth factor-like domain;
293-326 3.10e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 3.10e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 442631782    293 ECEPRvNPC-HDECINLPGSFRCgACPTGYTGDGR 326
Cdd:smart00181    1 ECASG-GPCsNGTCINTPGSYTC-SCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
466-496 3.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 3.29e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 442631782    466 PSPCLNGGTCRLLPDAkYQCVCPRGYT-GTTC 496
Cdd:smart00179    8 GNPCQNGGTCVNTVGS-YRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
430-458 9.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 9.43e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 442631782    430 HPCQNNGTCVqNGRGT-TCICQPGYS-GVVC 458
Cdd:smart00179    9 NPCQNGGTCV-NTVGSyRCECPPGYTdGRNC 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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