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Conserved domains on  [gi|24663419|ref|NP_729822|]
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uncharacterized protein Dmel_CG32109 [Drosophila melanogaster]

Protein Classification

adaptin-binding domain-containing protein( domain architecture ID 10562885)

adaptin-binding domain-containing protein similar to fungal increased recombination centers protein 6 (IRC6) and mammalian alpha- and gamma-adaptin-binding protein p34 (AAGAB) that may be involved in endocytic recycling of growth factor receptors such as EGFR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adaptin_binding super family cl10891
Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. ...
 149-219 9.28e-08

Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.


The actual alignment was detected with superfamily member pfam10199:

Pssm-ID: 462994  Cd Length: 96  Bit Score: 48.66  E-value: 9.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663419   149 EKDYEEVVEGLKNVVWSNVKFGSDH----KEEISADELDSQLK------------------DFENLLLTAQNLRNDT-SL 205
Cdd:pfam10199   2 KQGIERIVEILETHEWSNMELKSDDgslqREKLSLEKADSQGQslpngkdlqdgdeeldveDFENLLSKLKQARDMArEL 81

                          90
                  ....*....|....
gi 24663419   206 TREQFLDRAEQFAG 219
Cdd:pfam10199  82 PDEERKEFAAKVAE 95
 
Name Accession Description Interval E-value
Adaptin_binding pfam10199
Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. ...
 149-219 9.28e-08

Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.


Pssm-ID: 462994  Cd Length: 96  Bit Score: 48.66  E-value: 9.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663419   149 EKDYEEVVEGLKNVVWSNVKFGSDH----KEEISADELDSQLK------------------DFENLLLTAQNLRNDT-SL 205
Cdd:pfam10199   2 KQGIERIVEILETHEWSNMELKSDDgslqREKLSLEKADSQGQslpngkdlqdgdeeldveDFENLLSKLKQARDMArEL 81

                          90
                  ....*....|....
gi 24663419   206 TREQFLDRAEQFAG 219
Cdd:pfam10199  82 PDEERKEFAAKVAE 95
 
Name Accession Description Interval E-value
Adaptin_binding pfam10199
Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. ...
 149-219 9.28e-08

Alpha and gamma adaptin binding protein p34; p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.


Pssm-ID: 462994  Cd Length: 96  Bit Score: 48.66  E-value: 9.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663419   149 EKDYEEVVEGLKNVVWSNVKFGSDH----KEEISADELDSQLK------------------DFENLLLTAQNLRNDT-SL 205
Cdd:pfam10199   2 KQGIERIVEILETHEWSNMELKSDDgslqREKLSLEKADSQGQslpngkdlqdgdeeldveDFENLLSKLKQARDMArEL 81

                          90
                  ....*....|....
gi 24663419   206 TREQFLDRAEQFAG 219
Cdd:pfam10199  82 PDEERKEFAAKVAE 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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