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Conserved domains on  [gi|24664631|ref|NP_730047|]
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methionine sulfoxide reductase A, isoform B [Drosophila melanogaster]

Protein Classification

peptide-methionine (S)-S-oxide reductase MsrA( domain architecture ID 10483118)

peptide-methionine (S)-S-oxide reductase MsrA catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

EC:  1.8.4.11
Gene Ontology:  GO:0008113|GO:0036211|GO:0033744
PubMed:  11063566|10841552

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PMSR pfam01625
Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine ...
41-170 2.61e-55

Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.


:

Pssm-ID: 460270  Cd Length: 153  Bit Score: 174.11  E-value: 2.61e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631    41 TATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEygLT 112
Cdd:pfam01625   1 TATFAGGCFWGVEALFERLPGVISTEVGYAGGHTENPTyeevcsgtTGHAEAVQVVYDPEVISYEELLELFFEIHD--PT 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24664631   113 TP------IKRQYASLILYHDEEQKQVAHASKLEEQERRA-PEIITTEIASKENFYPAEAYHQKY 170
Cdd:pfam01625  79 TLnrqgndVGTQYRSAIFYHDEEQKEIAEASIAELQASGRyGKPIVTEIEPAGNFYPAEDYHQDY 143
 
Name Accession Description Interval E-value
PMSR pfam01625
Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine ...
41-170 2.61e-55

Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.


Pssm-ID: 460270  Cd Length: 153  Bit Score: 174.11  E-value: 2.61e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631    41 TATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEygLT 112
Cdd:pfam01625   1 TATFAGGCFWGVEALFERLPGVISTEVGYAGGHTENPTyeevcsgtTGHAEAVQVVYDPEVISYEELLELFFEIHD--PT 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24664631   113 TP------IKRQYASLILYHDEEQKQVAHASKLEEQERRA-PEIITTEIASKENFYPAEAYHQKY 170
Cdd:pfam01625  79 TLnrqgndVGTQYRSAIFYHDEEQKEIAEASIAELQASGRyGKPIVTEIEPAGNFYPAEDYHQDY 143
MsrA COG0225
Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, ...
40-170 1.47e-50

Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439995  Cd Length: 177  Bit Score: 162.96  E-value: 1.47e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631  40 ATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEygL 111
Cdd:COG0225   5 ETATFAGGCFWCVEAVFEQLPGVISVVSGYAGGHTPNPTyeevcsgrTGHAEAVQVTYDPAVISYEELLEVFFEIHD--P 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24664631 112 TTP------IKRQYASLILYHDEEQKQVAHASKLEEQER-RAPeiITTEIASKENFYPAEAYHQKY 170
Cdd:COG0225  83 TQLnrqgndRGTQYRSAIFYHDEEQKEIAEASIAALQASlDGP--IVTEIEPAKTFYPAEDYHQDY 146
PRK05550 PRK05550
bifunctional methionine sulfoxide reductase B/A protein; Provisional
27-170 2.60e-41

bifunctional methionine sulfoxide reductase B/A protein; Provisional


Pssm-ID: 235499 [Multi-domain]  Cd Length: 283  Bit Score: 142.34  E-value: 2.60e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631   27 LNISPVHDVNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT------GD--HTEVLEIDYDPTVISFKE 98
Cdd:PRK05550 115 LDFVPAEEGAYDTEEAIFAGGCFWGVEYYFKKLPGVLSVESGYTGGDTKNPTyeqvcsGTtgHAEAVRVEFDPAKISYET 194
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24664631   99 LLDLFWNNHEYgltTPIKRQ-------YASLILYHDEEQKQVAHASKLEEQERRAPeiITTEIASKENFYPAEAYHQKY 170
Cdd:PRK05550 195 LLKVFFEIHDP---TQLNRQgpdigtqYRSAIFYHDDEQKQIAEKLIAELTKKGYP--VVTEVEAAGPFYPAEDYHQDY 268
msrA TIGR00401
methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase ...
41-170 1.32e-38

methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens. [Protein fate, Protein modification and repair, Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 129496  Cd Length: 149  Bit Score: 131.41  E-value: 1.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631    41 TATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEyglt 112
Cdd:TIGR00401   2 IATFAGGCFWGTEKYFRLIPGVVSTAVGYTNGYTPNPTyeevcsgdTGHAEAVQVTYDPKVISYEELLDVFWEIHD---- 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24664631   113 tPIKR---------QYASLILYHDEEQKQVAHASKLEEQER-RAPEIITTEIASKENFYPAEAYHQKY 170
Cdd:TIGR00401  78 -PTTGnrqgndigtQYRSGIYYHSDAQEKAAAASKERLQAAaNYGDPIVTEIEPAENFYYAEEYHQQY 144
 
Name Accession Description Interval E-value
PMSR pfam01625
Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine ...
41-170 2.61e-55

Peptide methionine sulfoxide reductase; This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.


Pssm-ID: 460270  Cd Length: 153  Bit Score: 174.11  E-value: 2.61e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631    41 TATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEygLT 112
Cdd:pfam01625   1 TATFAGGCFWGVEALFERLPGVISTEVGYAGGHTENPTyeevcsgtTGHAEAVQVVYDPEVISYEELLELFFEIHD--PT 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24664631   113 TP------IKRQYASLILYHDEEQKQVAHASKLEEQERRA-PEIITTEIASKENFYPAEAYHQKY 170
Cdd:pfam01625  79 TLnrqgndVGTQYRSAIFYHDEEQKEIAEASIAELQASGRyGKPIVTEIEPAGNFYPAEDYHQDY 143
MsrA COG0225
Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, ...
40-170 1.47e-50

Peptide methionine sulfoxide reductase MsrA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439995  Cd Length: 177  Bit Score: 162.96  E-value: 1.47e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631  40 ATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEygL 111
Cdd:COG0225   5 ETATFAGGCFWCVEAVFEQLPGVISVVSGYAGGHTPNPTyeevcsgrTGHAEAVQVTYDPAVISYEELLEVFFEIHD--P 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24664631 112 TTP------IKRQYASLILYHDEEQKQVAHASKLEEQER-RAPeiITTEIASKENFYPAEAYHQKY 170
Cdd:COG0225  83 TQLnrqgndRGTQYRSAIFYHDEEQKEIAEASIAALQASlDGP--IVTEIEPAKTFYPAEDYHQDY 146
PRK05550 PRK05550
bifunctional methionine sulfoxide reductase B/A protein; Provisional
27-170 2.60e-41

bifunctional methionine sulfoxide reductase B/A protein; Provisional


Pssm-ID: 235499 [Multi-domain]  Cd Length: 283  Bit Score: 142.34  E-value: 2.60e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631   27 LNISPVHDVNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT------GD--HTEVLEIDYDPTVISFKE 98
Cdd:PRK05550 115 LDFVPAEEGAYDTEEAIFAGGCFWGVEYYFKKLPGVLSVESGYTGGDTKNPTyeqvcsGTtgHAEAVRVEFDPAKISYET 194
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24664631   99 LLDLFWNNHEYgltTPIKRQ-------YASLILYHDEEQKQVAHASKLEEQERRAPeiITTEIASKENFYPAEAYHQKY 170
Cdd:PRK05550 195 LLKVFFEIHDP---TQLNRQgpdigtqYRSAIFYHDDEQKQIAEKLIAELTKKGYP--VVTEVEAAGPFYPAEDYHQDY 268
PRK13014 PRK13014
methionine sulfoxide reductase A; Provisional
35-170 7.99e-40

methionine sulfoxide reductase A; Provisional


Pssm-ID: 237269  Cd Length: 186  Bit Score: 135.53  E-value: 7.99e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631   35 VNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLP--------TGDHTEVLEIDYDPTVISFKELLDLFWNN 106
Cdd:PRK13014   4 AADGMETATFAGGCFWGVEGVFQHVPGVVSVVSGYSGGHVDNPtyeqvctgTTGHAEAVQITYDPKQVSYENLLQIFFST 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24664631  107 HEyglTTPIKRQ-------YASLILYHDEEQKQVAHASK--LEEQeRRAPEIITTEIASKENFYPAEAYHQKY 170
Cdd:PRK13014  84 HD---PTQLNRQgpdrgeqYRSAIFYHDEEQKKVAEAYIaqLDEA-GIFKKPIVTPIKPYKNFYPAEDYHQDY 152
msrA TIGR00401
methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase ...
41-170 1.32e-38

methionine-S-sulfoxide reductase; This model describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens. [Protein fate, Protein modification and repair, Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 129496  Cd Length: 149  Bit Score: 131.41  E-value: 1.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631    41 TATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPT--------GDHTEVLEIDYDPTVISFKELLDLFWNNHEyglt 112
Cdd:TIGR00401   2 IATFAGGCFWGTEKYFRLIPGVVSTAVGYTNGYTPNPTyeevcsgdTGHAEAVQVTYDPKVISYEELLDVFWEIHD---- 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24664631   113 tPIKR---------QYASLILYHDEEQKQVAHASKLEEQER-RAPEIITTEIASKENFYPAEAYHQKY 170
Cdd:TIGR00401  78 -PTTGnrqgndigtQYRSGIYYHSDAQEKAAAASKERLQAAaNYGDPIVTEIEPAENFYYAEEYHQQY 144
PRK14018 PRK14018
bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide ...
47-199 5.56e-16

bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB;


Pssm-ID: 184456 [Multi-domain]  Cd Length: 521  Bit Score: 76.45  E-value: 5.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631   47 GCFWGAESLYGATRGVLRTTVGYAGGSSDLPTGD-------HTEVLEIDYDPTVISFKELLDLFW----------NNHEY 109
Cdd:PRK14018 206 GCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYEdvyrhsgHAETVKVTYDADKLSLDTILQYYFrvvdptslnkQGNDT 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664631  110 GLttpikrQYASLILYHDEEQKQVAHASKLEEQER-RAPeiITTEIASKENFYPAEAYHQKYRLQG-----HKDLASSLN 183
Cdd:PRK14018 286 GT------QYRSGVYYTDPADKAVIAAALKREQQKyQLP--LVVENEPLKNFYDAEEYHQDYLIKNpngycHIDLRKADE 357
                        170
                 ....*....|....*.
gi 24664631  184 LSPKLLQTSYVATKLN 199
Cdd:PRK14018 358 PLPGKTKTAPQGKGFD 373
PRK05528 PRK05528
peptide-methionine (S)-S-oxide reductase;
40-103 3.13e-05

peptide-methionine (S)-S-oxide reductase;


Pssm-ID: 235497  Cd Length: 156  Bit Score: 43.08  E-value: 3.13e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24664631   40 ATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPTGD---HTEVLEIDYDPTVISFKELLDLF 103
Cdd:PRK05528   2 ETVYFAGGCLWGVQAFFKTLPGVIHTEAGRANGRTSTLDGPydgYAECVKTHFDPRMVSITDLMGYL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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