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Conserved domains on  [gi|24665422|ref|NP_730184|]
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artemis, isoform A [Drosophila melanogaster]

Protein Classification

IBN_N and KAP95 domain-containing protein( domain architecture ID 12223118)

IBN_N and KAP95 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
29-90 1.83e-10

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 57.64  E-value: 1.83e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24665422      29 KAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKklRHWQLVPAEHQAAIKSNMLQVLI 90
Cdd:smart00913    7 QFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKIT--RRWSSLPEEEKEEIKNSLLELLL 66
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
304-702 3.70e-07

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 54.56  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  304 LSVLFEVIC-QDDLKEDDDYfsseslnSPSNAAAQTLDLMAlHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIA 382
Cdd:COG5215  323 LPELLSLLEkQGEDYYGDDW-------NPSMAASSCLQLFA-QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVM 394
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  383 EGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTIckfAPQIlpvlfdYLNQLVLELKVGEPDskH 462
Cdd:COG5215  395 HGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMII---SPCG------HLVLEVSASLIGLMD--C 463
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  463 MDRMF---YALETFCENLDED-------IVPYLPTLMDRLFGVMEPQ-NSNQMR----EMALSAIAAVSAAAKENLMPYF 527
Cdd:COG5215  464 PFRSIncsWRKENLVDHIAKAvrevesfLAKFYLAILNALVKGTELAlNESNLRvslfSALGTLILICPDAVSDILAGFY 543
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  528 PRIMTVLQGCL-----VKDCPKEMYSQRIQA--IDTLAALCRELGKDnIIPLADETMNFCLMMLEDGpdDPEF-RRSIYN 599
Cdd:COG5215  544 DYTSKKLDECIsvlgqILATEDQLLVEELQSnyIGVLEAIIRTRRRD-IEDVEDQLMELFIRILEST--KPTTaFGDVYT 620
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  600 LMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEI---DLEHTDDEDDQDAYLGENdyi 676
Cdd:COG5215  621 AISALSTSLEERFEQYASKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIyadVLMSSLVQCLSSEATHRD--- 697
                        410       420
                 ....*....|....*....|....*..
gi 24665422  677 veKEEAILS-LKEFATHTGAAFAPYLQ 702
Cdd:COG5215  698 --LKPAILSvFGDIALAIGANFESYLD 722
 
Name Accession Description Interval E-value
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
29-90 1.83e-10

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 57.64  E-value: 1.83e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24665422      29 KAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKklRHWQLVPAEHQAAIKSNMLQVLI 90
Cdd:smart00913    7 QFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKIT--RRWSSLPEEEKEEIKNSLLELLL 66
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
304-702 3.70e-07

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 54.56  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  304 LSVLFEVIC-QDDLKEDDDYfsseslnSPSNAAAQTLDLMAlHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIA 382
Cdd:COG5215  323 LPELLSLLEkQGEDYYGDDW-------NPSMAASSCLQLFA-QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVM 394
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  383 EGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTIckfAPQIlpvlfdYLNQLVLELKVGEPDskH 462
Cdd:COG5215  395 HGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMII---SPCG------HLVLEVSASLIGLMD--C 463
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  463 MDRMF---YALETFCENLDED-------IVPYLPTLMDRLFGVMEPQ-NSNQMR----EMALSAIAAVSAAAKENLMPYF 527
Cdd:COG5215  464 PFRSIncsWRKENLVDHIAKAvrevesfLAKFYLAILNALVKGTELAlNESNLRvslfSALGTLILICPDAVSDILAGFY 543
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  528 PRIMTVLQGCL-----VKDCPKEMYSQRIQA--IDTLAALCRELGKDnIIPLADETMNFCLMMLEDGpdDPEF-RRSIYN 599
Cdd:COG5215  544 DYTSKKLDECIsvlgqILATEDQLLVEELQSnyIGVLEAIIRTRRRD-IEDVEDQLMELFIRILEST--KPTTaFGDVYT 620
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  600 LMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEI---DLEHTDDEDDQDAYLGENdyi 676
Cdd:COG5215  621 AISALSTSLEERFEQYASKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIyadVLMSSLVQCLSSEATHRD--- 697
                        410       420
                 ....*....|....*....|....*..
gi 24665422  677 veKEEAILS-LKEFATHTGAAFAPYLQ 702
Cdd:COG5215  698 --LKPAILSvFGDIALAIGANFESYLD 722
IBN_N pfam03810
Importin-beta N-terminal domain;
29-90 1.78e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 40.69  E-value: 1.78e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24665422     29 KAYENPDSLLVLTQIVMSDR-PVQERQVAAVLLKRRVKklRHWQL----VPAEHQAAIKSNMLQVLI 90
Cdd:pfam03810    7 QFEKSPGFWSKLLQILSNSEnPLEVRQLAALYLKNLIT--RHWEEeknsLPPEEKEQIKNNLLNLLG 71
 
Name Accession Description Interval E-value
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
29-90 1.83e-10

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 57.64  E-value: 1.83e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24665422      29 KAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKklRHWQLVPAEHQAAIKSNMLQVLI 90
Cdd:smart00913    7 QFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKIT--RRWSSLPEEEKEEIKNSLLELLL 66
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
304-702 3.70e-07

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 54.56  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  304 LSVLFEVIC-QDDLKEDDDYfsseslnSPSNAAAQTLDLMAlHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIA 382
Cdd:COG5215  323 LPELLSLLEkQGEDYYGDDW-------NPSMAASSCLQLFA-QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVM 394
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  383 EGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTIckfAPQIlpvlfdYLNQLVLELKVGEPDskH 462
Cdd:COG5215  395 HGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMII---SPCG------HLVLEVSASLIGLMD--C 463
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  463 MDRMF---YALETFCENLDED-------IVPYLPTLMDRLFGVMEPQ-NSNQMR----EMALSAIAAVSAAAKENLMPYF 527
Cdd:COG5215  464 PFRSIncsWRKENLVDHIAKAvrevesfLAKFYLAILNALVKGTELAlNESNLRvslfSALGTLILICPDAVSDILAGFY 543
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  528 PRIMTVLQGCL-----VKDCPKEMYSQRIQA--IDTLAALCRELGKDnIIPLADETMNFCLMMLEDGpdDPEF-RRSIYN 599
Cdd:COG5215  544 DYTSKKLDECIsvlgqILATEDQLLVEELQSnyIGVLEAIIRTRRRD-IEDVEDQLMELFIRILEST--KPTTaFGDVYT 620
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665422  600 LMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEI---DLEHTDDEDDQDAYLGENdyi 676
Cdd:COG5215  621 AISALSTSLEERFEQYASKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIyadVLMSSLVQCLSSEATHRD--- 697
                        410       420
                 ....*....|....*....|....*..
gi 24665422  677 veKEEAILS-LKEFATHTGAAFAPYLQ 702
Cdd:COG5215  698 --LKPAILSvFGDIALAIGANFESYLD 722
IBN_N pfam03810
Importin-beta N-terminal domain;
29-90 1.78e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 40.69  E-value: 1.78e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24665422     29 KAYENPDSLLVLTQIVMSDR-PVQERQVAAVLLKRRVKklRHWQL----VPAEHQAAIKSNMLQVLI 90
Cdd:pfam03810    7 QFEKSPGFWSKLLQILSNSEnPLEVRQLAALYLKNLIT--RHWEEeknsLPPEEKEQIKNNLLNLLG 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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