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Conserved domains on  [gi|24668286|ref|NP_730672|]
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antioxidant 1 copper chaperone, isoform A [Drosophila melanogaster]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10006509)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; similar to heavy metal-associated isoprenylated plant protein (HIPP), Synechocystis Pcc6803 zinc-transporting ATPase, and Salmonella enterica gold resistance metallochaperone GolB which exhibits selectivity toward the Au(I) cation

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098|8091505|9437429

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
1-61 3.54e-11

Copper chaperone CopZ [Inorganic ion transport and metabolism];


:

Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 52.60  E-value: 3.54e-11
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24668286  1 MTVHEFKVE-MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSN---LSSDELMEQLRKTG 61
Cdd:COG2608  1 MKTVTLKVEgMTCGHCVARVEKALKAL-DGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAG 64
 
Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
1-61 3.54e-11

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 52.60  E-value: 3.54e-11
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24668286  1 MTVHEFKVE-MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSN---LSSDELMEQLRKTG 61
Cdd:COG2608  1 MKTVTLKVEgMTCGHCVARVEKALKAL-DGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAG 64
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 5-62 2.28e-09

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 47.99  E-value: 2.28e-09
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668286  5 EFKVE-MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSN--LSSDELMEQLRKTGK 62
Cdd:cd00371  1 ELSVEgMTCAGCVSKIEKALEKL-PGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGY 60
PLN02957 PLN02957
copper, zinc superoxide dismutase
 5-68 4.45e-08

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 47.44  E-value: 4.45e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24668286    5 EFKVEMTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSNLSSDELMEQLRKTGKSTTYVG 68
Cdd:PLN02957   9 EFMVDMKCEGCVAAVKNKLETL-EGVKAVEVDLSNQVVRVLGSSPVKAMTAALEQTGRKARLIG 71
HMA pfam00403
Heavy-metal-associated domain;
10-59 2.16e-06

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 40.30  E-value: 2.16e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 24668286   10 MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSNLSSDELMEQLRK 59
Cdd:pfam00403  7 MHCGGCAAKVEKALSEL-PGVLSVSVDLATKTVTVTGDAESTKLEKLVEA 55
 
Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
1-61 3.54e-11

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 52.60  E-value: 3.54e-11
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24668286  1 MTVHEFKVE-MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSN---LSSDELMEQLRKTG 61
Cdd:COG2608  1 MKTVTLKVEgMTCGHCVARVEKALKAL-DGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAG 64
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 5-62 2.28e-09

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 47.99  E-value: 2.28e-09
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668286  5 EFKVE-MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSN--LSSDELMEQLRKTGK 62
Cdd:cd00371  1 ELSVEgMTCAGCVSKIEKALEKL-PGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGY 60
PLN02957 PLN02957
copper, zinc superoxide dismutase
 5-68 4.45e-08

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 47.44  E-value: 4.45e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24668286    5 EFKVEMTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSNLSSDELMEQLRKTGKSTTYVG 68
Cdd:PLN02957   9 EFMVDMKCEGCVAAVKNKLETL-EGVKAVEVDLSNQVVRVLGSSPVKAMTAALEQTGRKARLIG 71
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
5-61 5.85e-08

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 47.44  E-value: 5.85e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668286   5 EFKVE-MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVT---SNLSSDELMEQLRKTG 61
Cdd:COG2217   4 RLRIEgMTCAACAWLIEKALRKL-PGVLSARVNLATERARVEydpGKVSLEELIAAVEKAG 63
HMA pfam00403
Heavy-metal-associated domain;
10-59 2.16e-06

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 40.30  E-value: 2.16e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 24668286   10 MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSNLSSDELMEQLRK 59
Cdd:pfam00403  7 MHCGGCAAKVEKALSEL-PGVLSVSVDLATKTVTVTGDAESTKLEKLVEA 55
copA PRK10671
copper-exporting P-type ATPase CopA;
10-61 3.54e-04

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 36.64  E-value: 3.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24668286   10 MTCGGCASAVERVLGKLgDKVEKVNINLEDRTVSVTSNLSSDELMEQLRKTG 61
Cdd:PRK10671 108 MSCASCVSRVQNALQSV-PGVTQARVNLAERTALVMGSASPQDLVQAVEKAG 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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