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Conserved domains on  [gi|24668824|ref|NP_730768|]
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Mesoderm-expressed 2, isoform B [Drosophila melanogaster]

Protein Classification

Myb/SANT-like transcription factor( domain architecture ID 10651957)

Myb/SANT-like transcription factor with an N-terminal MADF domain, which resembles the 3 alpha-helix bundle of the DNA-binding Myb domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
62-149 1.45e-26

subfamily of SANT domain;


:

Pssm-ID: 214738  Cd Length: 89  Bit Score: 102.05  E-value: 1.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668824     62 KLIQMVHDNPILWDSRLPNFKGAEEeKNRAWEHIGREFNAPGRRVARAFKSLRESYRRELAHVKL--MGNGFKPKWSLYE 139
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEE-KRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNgkSGGGKKSKWEYFD 79

                           90
                   ....*....|
gi 24668824    140 AMDFLRDVIR 149
Cdd:smart00595  80 RLSFLRPVIR 89
 
Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
62-149 1.45e-26

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 102.05  E-value: 1.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668824     62 KLIQMVHDNPILWDSRLPNFKGAEEeKNRAWEHIGREFNAPGRRVARAFKSLRESYRRELAHVKL--MGNGFKPKWSLYE 139
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEE-KRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNgkSGGGKKSKWEYFD 79

                           90
                   ....*....|
gi 24668824    140 AMDFLRDVIR 149
Cdd:smart00595  80 RLSFLRPVIR 89
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 63-144 1.18e-22

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 91.19  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668824    63 LIQMVHDNPILWDSRLPNFKGAeEEKNRAWEHIGREFNA--PGRRVARAFKSLRESYRRELAHVK-LMGNGFKPKWSLYE 139
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNR-DARERAWEEIAEELGSdvPVEDCKKRWKNLRDQYRRELRRKRtNSGELYKSRWYYYE 79


                  ....*
gi 24668824   140 AMDFL 144
Cdd:pfam10545  80 ELSFL 84
 
Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
62-149 1.45e-26

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 102.05  E-value: 1.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668824     62 KLIQMVHDNPILWDSRLPNFKGAEEeKNRAWEHIGREFNAPGRRVARAFKSLRESYRRELAHVKL--MGNGFKPKWSLYE 139
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEE-KRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNgkSGGGKKSKWEYFD 79

                           90
                   ....*....|
gi 24668824    140 AMDFLRDVIR 149
Cdd:smart00595  80 RLSFLRPVIR 89
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 63-144 1.18e-22

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 91.19  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668824    63 LIQMVHDNPILWDSRLPNFKGAeEEKNRAWEHIGREFNA--PGRRVARAFKSLRESYRRELAHVK-LMGNGFKPKWSLYE 139
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNR-DARERAWEEIAEELGSdvPVEDCKKRWKNLRDQYRRELRRKRtNSGELYKSRWYYYE 79


                  ....*
gi 24668824   140 AMDFL 144
Cdd:pfam10545  80 ELSFL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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