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Conserved domains on  [gi|24644768|ref|NP_731141|]
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stranded at second, isoform B [Drosophila melanogaster]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10676162)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-824 3.77e-09

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 54.06  E-value: 3.77e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644768     752 CTFKGAEYDVGQQFRDGCDQLCICNEQG-IHCAKLECPSNfgldvqdPHCIRWEPVPAdfkpsPPNCCPesmRC 824
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPP-------PDCPNPERVKP-----PGECCP---RC 59
fn3 pfam00041
Fibronectin type III domain;
1413-1479 3.11e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 3.11e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24644768   1413 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEI 1479
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1516-1605 6.87e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 6.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768 1516 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRaIYQSDAGKEDSSVFKVAKRDSTTgTLIMDLKPGTKYRLWLEMYLTNGNT 1595
Cdd:cd00063    7 LRVTDVTSTSVTLSWTPPEDDGGPITG-YV-VEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGGGES 83

                         90
                 ....*....|
gi 24644768 1596 KKSNVVNFIT 1605
Cdd:cd00063   84 PPSESVTVTT 93
 
Name Accession Description Interval E-value
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-824 3.77e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 54.06  E-value: 3.77e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644768     752 CTFKGAEYDVGQQFRDGCDQLCICNEQG-IHCAKLECPSNfgldvqdPHCIRWEPVPAdfkpsPPNCCPesmRC 824
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPP-------PDCPNPERVKP-----PGECCP---RC 59
fn3 pfam00041
Fibronectin type III domain;
1413-1479 3.11e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 3.11e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24644768   1413 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEI 1479
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1516-1605 6.87e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 6.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768 1516 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRaIYQSDAGKEDSSVFKVAKRDSTTgTLIMDLKPGTKYRLWLEMYLTNGNT 1595
Cdd:cd00063    7 LRVTDVTSTSVTLSWTPPEDDGGPITG-YV-VEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGGGES 83

                         90
                 ....*....|
gi 24644768 1596 KKSNVVNFIT 1605
Cdd:cd00063   84 PPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1411-1490 1.04e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.04e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768    1411 PELTVSETNASWLQLTWKK-LGDDQMEYVDGVQLRYKELTGMiySSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGH 1489
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 24644768    1490 G 1490
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1413-1491 1.35e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24644768 1413 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGHGA 1491
Cdd:cd00063    7 LRVTDVTSTSVTLSWTPPEDDGGP-ITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1516-1586 1.42e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.42e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644768    1516 VNVTKVKTQSVEISWNGvpyPEDKFVHIYRAIYQSDAGKEDSSVFKVAKRDSTTGTLIMDLKPGTKYRLWL 1586
Cdd:smart00060    7 LRVTDVTSTSVTLSWEP---PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1516-1598 5.88e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768   1516 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRAIYQSDAGKEDSSVFKVAKrdSTTGTLIMDLKPGTKYRLWLEMYLTNGNT 1595
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITG-YEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 24644768   1596 KKS 1598
Cdd:pfam00041   83 PPS 85
 
Name Accession Description Interval E-value
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-824 3.77e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 54.06  E-value: 3.77e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644768     752 CTFKGAEYDVGQQFRDGCDQLCICNEQG-IHCAKLECPSNfgldvqdPHCIRWEPVPAdfkpsPPNCCPesmRC 824
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPP-------PDCPNPERVKP-----PGECCP---RC 59
fn3 pfam00041
Fibronectin type III domain;
1413-1479 3.11e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 3.11e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24644768   1413 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEI 1479
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1516-1605 6.87e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 6.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768 1516 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRaIYQSDAGKEDSSVFKVAKRDSTTgTLIMDLKPGTKYRLWLEMYLTNGNT 1595
Cdd:cd00063    7 LRVTDVTSTSVTLSWTPPEDDGGPITG-YV-VEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGGGES 83

                         90
                 ....*....|
gi 24644768 1596 KKSNVVNFIT 1605
Cdd:cd00063   84 PPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1411-1490 1.04e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.04e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768    1411 PELTVSETNASWLQLTWKK-LGDDQMEYVDGVQLRYKELTGMiySSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGH 1489
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 24644768    1490 G 1490
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1413-1491 1.35e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24644768 1413 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGHGA 1491
Cdd:cd00063    7 LRVTDVTSTSVTLSWTPPEDDGGP-ITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1516-1586 1.42e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.42e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644768    1516 VNVTKVKTQSVEISWNGvpyPEDKFVHIYRAIYQSDAGKEDSSVFKVAKRDSTTGTLIMDLKPGTKYRLWL 1586
Cdd:smart00060    7 LRVTDVTSTSVTLSWEP---PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1516-1598 5.88e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644768   1516 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRAIYQSDAGKEDSSVFKVAKrdSTTGTLIMDLKPGTKYRLWLEMYLTNGNT 1595
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITG-YEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 24644768   1596 KKS 1598
Cdd:pfam00041   83 PPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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