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Conserved domains on  [gi|24647961|ref|NP_732339|]
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kokopelli, isoform C [Drosophila melanogaster]

Protein Classification

cyclin-like FAM58 family protein( domain architecture ID 15334275)

cyclin-like FAM58 family protein similar to Homo sapiens cyclin-related protein FAM58A/B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 32-142 1.84e-47

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 153.09  E-value: 1.84e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  32 KPGVVPMYIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRG 111
Cdd:cd20534   1 EHFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKA-EEQPRRLRDIINVSYRILHPD 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647961 112 NDPVDLNDEYWSMRDAIVQAELLITRTLCFD 142
Cdd:cd20534  80 KPPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 147-252 4.17e-44

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 144.32  E-value: 4.17e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961 147 LAHKYLLHYMKTLQDWVGTEVWNSVPIAKAAASYLQDFHHSANILKYKPTHVAIGCLSLALQTYGIQVPLTDESdeSAMW 226
Cdd:cd20535   1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEA--EKPW 78

                        90       100
                ....*....|....*....|....*.
gi 24647961 227 YKPLVKDFTRENQWEIIENVIEVYKN 252
Cdd:cd20535  79 WQAFCEDLTKETIDEIIEDIINVYDL 104
 
Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 32-142 1.84e-47

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 153.09  E-value: 1.84e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  32 KPGVVPMYIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRG 111
Cdd:cd20534   1 EHFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKA-EEQPRRLRDIINVSYRILHPD 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647961 112 NDPVDLNDEYWSMRDAIVQAELLITRTLCFD 142
Cdd:cd20534  80 KPPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 147-252 4.17e-44

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 144.32  E-value: 4.17e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961 147 LAHKYLLHYMKTLQDWVGTEVWNSVPIAKAAASYLQDFHHSANILKYKPTHVAIGCLSLALQTYGIQVPLTDESdeSAMW 226
Cdd:cd20535   1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEA--EKPW 78

                        90       100
                ....*....|....*....|....*.
gi 24647961 227 YKPLVKDFTRENQWEIIENVIEVYKN 252
Cdd:cd20535  79 WQAFCEDLTKETIDEIIEDIINVYDL 104
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 6-144 1.28e-13

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 65.62  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961     6 DVMSMQQHVELNKAQTMKPIDYRKMNKP---GVVPMYIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGS 82
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPkmrAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24647961    83 LYLAGKIKEDESVKIRDVINVAyctlnrgndpvdlnDEYWSmRDAIVQAELLITRTLCFDLN 144
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYIT--------------DNAYT-REEILRMERLILETLNFDLS 127
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 46-217 3.58e-12

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 64.75  E-value: 3.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  46 KLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAyctlnrgNDPvdLNDEYWSMR 125
Cdd:COG5333  58 RLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKV-EDTPRDISIESFEA-------RDL--WSEEPKSSR 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961 126 DAIVQAELLITRTLCFDLNIDLAHKYLLHYMKTLQdwvgtEVWNSvPIAKAAASYLQDFHHSANILKYKPTHVAIGCLSL 205
Cdd:COG5333 128 ERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQ-----EKDKY-KLLQIAWKIINDALRTDLCLLYPPHIIALAALLI 201

                       170
                ....*....|..
gi 24647961 206 ALQTYGIQVPLT 217
Cdd:COG5333 202 ACEVLGMPIIKL 213
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 39-107 2.35e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 36.03  E-value: 2.35e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647961     39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIKEDESVKIRDVINVAYCT 107
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFT 70
 
Name Accession Description Interval E-value
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 32-142 1.84e-47

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 153.09  E-value: 1.84e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  32 KPGVVPMYIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRG 111
Cdd:cd20534   1 EHFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKA-EEQPRRLRDIINVSYRILHPD 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647961 112 NDPVDLNDEYWSMRDAIVQAELLITRTLCFD 142
Cdd:cd20534  80 KPPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 147-252 4.17e-44

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 144.32  E-value: 4.17e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961 147 LAHKYLLHYMKTLQDWVGTEVWNSVPIAKAAASYLQDFHHSANILKYKPTHVAIGCLSLALQTYGIQVPLTDESdeSAMW 226
Cdd:cd20535   1 LPHKYLLHYLKSLRDWLNPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEA--EKPW 78

                        90       100
                ....*....|....*....|....*.
gi 24647961 227 YKPLVKDFTRENQWEIIENVIEVYKN 252
Cdd:cd20535  79 WQAFCEDLTKETIDEIIEDIINVYDL 104
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 39-141 2.55e-17

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 75.67  E-value: 2.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIKEDeSVKIRDVINV----AYCTLNRGNDP 114
Cdd:cd20532  18 LIQDAGILLKLPQVVMATAQVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEET-PRRLRDVINVfhrlLQRRLGKPAEV 96

                        90       100       110
                ....*....|....*....|....*....|
gi 24647961 115 VDLN---DEYWSMRDAIVQAELLITRTLCF 141
Cdd:cd20532  97 LPLDigsAEYEELKNDIIKAERRILKELGF 126
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 39-143 5.22e-15

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 69.37  E-value: 5.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRD-VINVAYCTLNRGNDPVDL 117
Cdd:cd20545  11 FIIRVGSRLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKV-EESGRKLRDiVIACAKVAQKNPNLVIDE 89

                        90       100
                ....*....|....*....|....*..
gi 24647961 118 ND-EYWSMRDAIVQAELLITRTLCFDL 143
Cdd:cd20545  90 QSkEVWRWRDSILYNEEVLLETLCFDL 116
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 6-144 1.28e-13

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 65.62  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961     6 DVMSMQQHVELNKAQTMKPIDYRKMNKP---GVVPMYIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGS 82
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPkmrAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24647961    83 LYLAGKIKEDESVKIRDVINVAyctlnrgndpvdlnDEYWSmRDAIVQAELLITRTLCFDLN 144
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYIT--------------DNAYT-REEILRMERLILETLNFDLS 127
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 39-142 9.16e-13

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 63.02  E-value: 9.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRGndpvDLN 118
Cdd:cd20530  17 FIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKV-EETPKKCKDIIKTARSLLNDK----QFA 91

                        90       100
                ....*....|....*....|....
gi 24647961 119 DEYWSMRDAIVQAELLITRTLCFD 142
Cdd:cd20530  92 QFGDDPKEEVMVLERILLQTIKFD 115
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 46-217 3.58e-12

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 64.75  E-value: 3.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  46 KLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAyctlnrgNDPvdLNDEYWSMR 125
Cdd:COG5333  58 RLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKV-EDTPRDISIESFEA-------RDL--WSEEPKSSR 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961 126 DAIVQAELLITRTLCFDLNIDLAHKYLLHYMKTLQdwvgtEVWNSvPIAKAAASYLQDFHHSANILKYKPTHVAIGCLSL 205
Cdd:COG5333 128 ERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQ-----EKDKY-KLLQIAWKIINDALRTDLCLLYPPHIIALAALLI 201

                       170
                ....*....|..
gi 24647961 206 ALQTYGIQVPLT 217
Cdd:COG5333 202 ACEVLGMPIIKL 213
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 40-142 9.24e-10

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 55.48  E-value: 9.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  40 IFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRGNDPVDLN- 118
Cdd:cd20538  35 IQEMGQRLQVSQLCINTAIVYMHRFYMFHSFTKFHRNSIAAAALFLAAKV-EEQPRKLEHVIKVAHACLHRGEPDLDTKs 113

                        90       100
                ....*....|....*....|....
gi 24647961 119 DEYWSMRDAIVQAELLITRTLCFD 142
Cdd:cd20538 114 EAYLQQAQELVINENILLQTLGFE 137
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 46-142 1.33e-09

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 54.83  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  46 KLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNR----GNDPVDLNDEY 121
Cdd:cd20587  25 RLKVPQVTIATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKV-EETPRPLKDVIVVSYEIIFKkdpsAAQRIKQKEVY 103

                        90       100
                ....*....|....*....|.
gi 24647961 122 WSMRDAIVQAELLITRTLCFD 142
Cdd:cd20587 104 EQQKELVLNGEKLVLSTLGFD 124
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 39-142 7.00e-08

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 49.65  E-value: 7.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYctLNRGNDPVDLN 118
Cdd:cd20547   8 FISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKI-EDTQKKSKDILAASY--NLRHPDKISVD 84

                        90       100
                ....*....|....*....|....*
gi 24647961 119 DEYW-SMRDAIVQAELLITRTLCFD 142
Cdd:cd20547  85 DQMLeEFRKAILGLERLLLETICFD 109
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 40-142 6.55e-07

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 47.73  E-value: 6.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  40 IFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRGNDPVDL-N 118
Cdd:cd20596  37 IQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKV-EEQPRKLEHVIKVAHACLNPLEPQLDTkS 115

                        90       100
                ....*....|....*....|....
gi 24647961 119 DEYWSMRDAIVQAELLITRTLCFD 142
Cdd:cd20596 116 DAYLQQAQELVILETIMLQTLGFE 139
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 39-107 1.82e-06

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 44.71  E-value: 1.82e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647961  39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCT 107
Cdd:cd00043   5 FIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKL-EELPRTLKEIAKVSGVS 72
CYCLIN_CCNL1_rpt1 cd20589
first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 47-141 3.84e-06

first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410292 [Multi-domain]  Cd Length: 124  Bit Score: 45.12  E-value: 3.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  47 LKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIKEDESvKIRDVINVAY----CTLNRGNDPVDLNDEYW 122
Cdd:cd20589  26 LRLPQVAMATGQVLFQRFFYSKSFVKHSMEIVAMACINLASKIEEAPR-RIRDVINVFHhikqVRGKRTISPLILDQNYI 104

                        90
                ....*....|....*....
gi 24647961 123 SMRDAIVQAELLITRTLCF 141
Cdd:cd20589 105 NLKNQVIKAERRVLKELGF 123
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 46-142 2.52e-05

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 43.12  E-value: 2.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  46 KLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVAYCTLNRGNDPVDLNDE-YWSM 124
Cdd:cd20595  42 RLNVSQLTINTAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKV-EEQPKKLEHVIKVAHTCLHPQESLPDTRSEaYLQQ 120

                        90
                ....*....|....*...
gi 24647961 125 RDAIVQAELLITRTLCFD 142
Cdd:cd20595 121 VQDLVILESIILQTLGFE 138
CYCLIN_CCNL2_rpt1 cd20590
first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 47-141 4.91e-05

first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410293 [Multi-domain]  Cd Length: 156  Bit Score: 42.69  E-value: 4.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  47 LKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIkEDESVKIRDVINVaYCTLNRGND-----PVDLNDEY 121
Cdd:cd20590  58 LRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKI-EEAPRRIRDVINV-FHRLRQLREkkkpvPLILDQEY 135

                        90       100
                ....*....|....*....|
gi 24647961 122 WSMRDAIVQAELLITRTLCF 141
Cdd:cd20590 136 VNLKNQIIKAERRVLKELGF 155
CYCLIN_AcCycL_rpt1 cd20591
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 40-141 2.14e-04

first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410294 [Multi-domain]  Cd Length: 128  Bit Score: 40.20  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961  40 IFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIKEDESvKIRDVINVAY-CTLNRGNDPVDLN 118
Cdd:cd20591  22 IQESGILLKLPQAVMATGQVLFQRFYCKKSFARFNVKRVAASCVWLAAKLEESPR-KIRQVLMVFHrMECRRENLPLEPL 100

                        90       100
                ....*....|....*....|....*..
gi 24647961 119 D----EYWSMRDAIVQAELLITRTLCF 141
Cdd:cd20591 101 EpeskKYDEMKEDLIRTERHLLKEMGF 127
CYCLIN_CCNL_rpt2 cd20533
second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 149-216 1.81e-03

second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410236 [Multi-domain]  Cd Length: 92  Bit Score: 36.81  E-value: 1.81e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24647961 149 HKYLLHYMKTLQDWVGTEvwnsvpIAKAAASYLQDFHHSANILKYKPTHVAIGCLSLALQTYGIQVPL 216
Cdd:cd20533   3 HKFILMYLQVLEGEDNKK------LAQTAWNYMNDSLRTDLCVRYPPEVIACACIYLAARELGIPLPL 64
CYCLIN_AcCycT_rpt2 cd20588
second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 154-250 2.24e-03

second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410291 [Multi-domain]  Cd Length: 93  Bit Score: 36.36  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647961 154 HYMKTLQDWVGTEVWNSVPIAKAAASYLQDFHHSANILKYKPTHVAIGCLSLALQTYGIQVPLTDESDesamWYKPLvkD 233
Cdd:cd20588   2 HPYKPLVAAIKKFNVAQNALAQAAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPCDGRKV----WWQEF--D 75

                        90
                ....*....|....*..
gi 24647961 234 FTRENQWEIIENVIEVY 250
Cdd:cd20588  76 VTPRQLEEVSNQMLELY 92
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 39-107 2.35e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 36.03  E-value: 2.35e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24647961     39 YIFECAAKLKMKPLTAACAAIVFHRFFREVKASDYDEFLIAAGSLYLAGKIKEDESVKIRDVINVAYCT 107
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFT 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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