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Conserved domains on  [gi|24648010|ref|NP_732361|]
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uncharacterized protein Dmel_CG31224, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1506-1531 7.99e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 7.99e-05
                           10        20
                   ....*....|....*....|....*.
gi 24648010   1506 ALVEHMRMHTGQTPLKCKICGKKFKR 1531
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1710-1733 1.60e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.60e-04
                           10        20
                   ....*....|....*....|....
gi 24648010   1710 NYMRHRREHHGTKKFTCDQCDKSF 1733
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1637-1780 3.64e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010 1637 QYDCAICSKSFSTKWNLKIH--SWVHANRTAKPFKC--EYCPKAFVRELDFKNHINAHKQIKPYTCEYCGC-------KF 1705
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsplLN 368

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24648010 1706 IRKYNYMRHRREHHGTKKFTCD--QCDKSFHRHYYLIEHRRMHTGERP--FTCTICGKSSTTKTNHNKHLKIHHSRDPF 1780
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
PHA00733 super family cl26169
hypothetical protein
 1527-1623 3.20e-03

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010  1527 KKFKRYSNLTQHRKRHTKMMVRKkeyVCHCGEVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRLAHSDKfd 1606
Cdd:PHA00733   26 EELKRYHSLTPEQKRLIRAVVKT---LIYNPQLLDESSYLYKLLTSKAVSPYVCPLCLMPFSSSVSLKQHIRYTEHSK-- 100

                          90
                  ....*....|....*..
gi 24648010  1607 yaepmECPMCKQIFAKT 1623
Cdd:PHA00733  101 -----VCPVCGKEFRNT 112
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1506-1531 7.99e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 7.99e-05
                           10        20
                   ....*....|....*....|....*.
gi 24648010   1506 ALVEHMRMHTGQTPLKCKICGKKFKR 1531
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1710-1733 1.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.60e-04
                           10        20
                   ....*....|....*....|....
gi 24648010   1710 NYMRHRREHHGTKKFTCDQCDKSF 1733
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1637-1780 3.64e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010 1637 QYDCAICSKSFSTKWNLKIH--SWVHANRTAKPFKC--EYCPKAFVRELDFKNHINAHKQIKPYTCEYCGC-------KF 1705
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsplLN 368

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24648010 1706 IRKYNYMRHRREHHGTKKFTCD--QCDKSFHRHYYLIEHRRMHTGERP--FTCTICGKSSTTKTNHNKHLKIHHSRDPF 1780
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1738-1763 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.69e-03
                           10        20
                   ....*....|....*....|....*.
gi 24648010   1738 YLIEHRRMHTGERPFTCTICGKSSTT 1763
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 1527-1623 3.20e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010  1527 KKFKRYSNLTQHRKRHTKMMVRKkeyVCHCGEVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRLAHSDKfd 1606
Cdd:PHA00733   26 EELKRYHSLTPEQKRLIRAVVKT---LIYNPQLLDESSYLYKLLTSKAVSPYVCPLCLMPFSSSVSLKQHIRYTEHSK-- 100

                          90
                  ....*....|....*..
gi 24648010  1607 yaepmECPMCKQIFAKT 1623
Cdd:PHA00733  101 -----VCPVCGKEFRNT 112
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1506-1531 7.99e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 7.99e-05
                           10        20
                   ....*....|....*....|....*.
gi 24648010   1506 ALVEHMRMHTGQTPLKCKICGKKFKR 1531
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1710-1733 1.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.60e-04
                           10        20
                   ....*....|....*....|....
gi 24648010   1710 NYMRHRREHHGTKKFTCDQCDKSF 1733
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1637-1780 3.64e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010 1637 QYDCAICSKSFSTKWNLKIH--SWVHANRTAKPFKC--EYCPKAFVRELDFKNHINAHKQIKPYTCEYCGC-------KF 1705
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfsplLN 368

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24648010 1706 IRKYNYMRHRREHHGTKKFTCD--QCDKSFHRHYYLIEHRRMHTGERP--FTCTICGKSSTTKTNHNKHLKIHHSRDPF 1780
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1521-1542 4.52e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 4.52e-04
                           10        20
                   ....*....|....*....|..
gi 24648010   1521 KCKICGKKFKRYSNLTQHRKRH 1542
Cdd:pfam00096    2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1738-1763 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.69e-03
                           10        20
                   ....*....|....*....|....*.
gi 24648010   1738 YLIEHRRMHTGERPFTCTICGKSSTT 1763
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 1527-1623 3.20e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.47  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010  1527 KKFKRYSNLTQHRKRHTKMMVRKkeyVCHCGEVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRLAHSDKfd 1606
Cdd:PHA00733   26 EELKRYHSLTPEQKRLIRAVVKT---LIYNPQLLDESSYLYKLLTSKAVSPYVCPLCLMPFSSSVSLKQHIRYTEHSK-- 100

                          90
                  ....*....|....*..
gi 24648010  1607 yaepmECPMCKQIFAKT 1623
Cdd:PHA00733  101 -----VCPVCGKEFRNT 112
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1696-1718 4.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.15e-03
                           10        20
                   ....*....|....*....|...
gi 24648010   1696 YTCEYCGCKFIRKYNYMRHRREH 1718
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1575-1770 5.07e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010 1575 LKPKCCPYCCDRFVHANSLRRHIRLAHSDkFDYAEPMECPMckqifaktsikahmathstepqydcAICSKSFSTKWNLK 1654
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSVNHS-GESLKPFSCPY-------------------------SLCGKLFSRNDALK 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648010 1655 IHSWVHANRTAKPFKCEYCPKAFVRELDFKNHINAHKQI-----KPYTCEYCGCK--FIRKYNYMRHRREH--HGTKKFT 1725
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETLSNSCIrnFKRDSNLSLHIITHlsFRPYNCK 420

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 24648010 1726 CDQCDKSFHRHYYLIEHRRMHTGERPFTCTICGKSSTTKT--NHNKH 1770
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDlsNHGKD 467
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1724-1746 7.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 7.77e-03
                           10        20
                   ....*....|....*....|...
gi 24648010   1724 FTCDQCDKSFHRHYYLIEHRRMH 1746
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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