|
Name |
Accession |
Description |
Interval |
E-value |
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
4-950 |
0e+00 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 1471.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 4 LLKSIFTCALFVIFVYATAQSLLKVQETEARQayLNVTSSSSSNLSQDDGHFLsrrlrqvshgeegdegapsqmddeleq 83
Cdd:TIGR00845 1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYY--------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 84 mtkvhgeapdaeelreCSEGLVLPLWMPQrNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
Cdd:TIGR00845 52 ----------------CKEGVILPIWEPQ-NPSVGDKIARATVYFVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKK 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRR 243
Cdd:TIGR00845 115 PNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRK 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 244 IRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVA 322
Cdd:TIGR00845 195 IKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKRYRAGKqRGMIIE 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 323 GEHDQVEMDAEKGPKQPMVTSARGN--------DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSR 394
Cdd:TIGR00845 275 TEGDRPKSKTEIEMDGKMVNSHVDNfldgalvlEVKEFDEARREMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSR 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 395 AFYRIQATRKMVGSGNLMRKIQERAHSDLTEVkaQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG-DISTY 473
Cdd:TIGR00845 355 AFYRIQATRLMTGAGNILKKHAADAARKAVSM--HEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGgDLTNT 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 474 ASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVK--------------LA 539
Cdd:TIGR00845 433 VYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLA 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 540 VPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES-KDYEGARGELVFENNES 618
Cdd:TIGR00845 513 SPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFEDTCGELEFENDET 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 619 EKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDELAAKIKEV-----EKKPVQDLTELDRILLLSKPRNGELTTAYVRIR 693
Cdd:TIGR00845 593 EKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNEtitddDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIE 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 694 ESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPAdESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTD 773
Cdd:TIGR00845 673 ESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAG-DDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTE 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 774 ICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAV 853
Cdd:TIGR00845 752 YWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAV 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 854 NVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRwHKGIGAELGGPKVSKYISAAILVFLW 933
Cdd:TIGR00845 832 NVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRR-RPEIGGELGGPRTAKLLTSALFVLLW 910
|
970
....*....|....*..
gi 24648586 934 VFYVVICILEAYDVIRV 950
Cdd:TIGR00845 911 LLYILFSSLEAYCHIKG 927
|
|
| Na_Ca_ex_C |
pfam16494 |
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ... |
300-417 |
1.38e-45 |
|
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.
Pssm-ID: 465141 Cd Length: 136 Bit Score: 160.16 E-value: 1.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 300 RRLLVYKYMDKNYRVNK-RGTVVAGEHD-------QVEMDAEKGPKQPMVTSARGN----DAEAFDEARREYITLLTELR 367
Cdd:pfam16494 1 RRLLFYKYLYKRYRADKrRGIIVETEGElgpkegiEMLMDGKLVGSHVMEGGAEGPvddpEAKELDEARREVIRILKELK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 24648586 368 QKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQE 417
Cdd:pfam16494 81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAA 130
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
441-529 |
1.44e-35 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 129.68 E-value: 1.44e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 441 PIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFE 520
Cdd:smart00237 1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80
|
....*....
gi 24648586 521 EDECFYIRL 529
Cdd:smart00237 81 KDETFYVRL 89
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
785-939 |
2.75e-13 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 71.32 E-value: 2.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 785 IFVIGVITAIIG-----DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAA--KHDEGAdncIGNVTGSNAVNVFL 857
Cdd:COG0530 156 LLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAArkGEDDLA---VGNIIGSNIFNILL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 858 GIGLAWTIAavyhsshgmtfnvePGTIGFAVALF--CGEALIAIMLIMFRRWHKGIGAelggpkvskyISAAILVFLWVF 935
Cdd:COG0530 233 VLGIGALIT--------------PIPVDPAVLSFdlPVMLAATLLLLGLLRTGGRIGR----------WEGLLLLALYLA 288
|
....
gi 24648586 936 YVVI 939
Cdd:COG0530 289 YLAL 292
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
781-862 |
2.96e-04 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 43.87 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 781 FVVSIFVIGVITAIIGD-----AASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNV 855
Cdd:PRK10734 3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNI 81
|
....*..
gi 24648586 856 FLGIGLA 862
Cdd:PRK10734 82 LLILGLA 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
4-950 |
0e+00 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 1471.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 4 LLKSIFTCALFVIFVYATAQSLLKVQETEARQayLNVTSSSSSNLSQDDGHFLsrrlrqvshgeegdegapsqmddeleq 83
Cdd:TIGR00845 1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYY--------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 84 mtkvhgeapdaeelreCSEGLVLPLWMPQrNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
Cdd:TIGR00845 52 ----------------CKEGVILPIWEPQ-NPSVGDKIARATVYFVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKK 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRR 243
Cdd:TIGR00845 115 PNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRK 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 244 IRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVA 322
Cdd:TIGR00845 195 IKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKRYRAGKqRGMIIE 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 323 GEHDQVEMDAEKGPKQPMVTSARGN--------DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSR 394
Cdd:TIGR00845 275 TEGDRPKSKTEIEMDGKMVNSHVDNfldgalvlEVKEFDEARREMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSR 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 395 AFYRIQATRKMVGSGNLMRKIQERAHSDLTEVkaQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG-DISTY 473
Cdd:TIGR00845 355 AFYRIQATRLMTGAGNILKKHAADAARKAVSM--HEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGgDLTNT 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 474 ASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVK--------------LA 539
Cdd:TIGR00845 433 VYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLA 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 540 VPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES-KDYEGARGELVFENNES 618
Cdd:TIGR00845 513 SPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFEDTCGELEFENDET 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 619 EKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDELAAKIKEV-----EKKPVQDLTELDRILLLSKPRNGELTTAYVRIR 693
Cdd:TIGR00845 593 EKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNEtitddDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIE 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 694 ESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPAdESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTD 773
Cdd:TIGR00845 673 ESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAG-DDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTE 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 774 ICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAV 853
Cdd:TIGR00845 752 YWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAV 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 854 NVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRwHKGIGAELGGPKVSKYISAAILVFLW 933
Cdd:TIGR00845 832 NVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRR-RPEIGGELGGPRTAKLLTSALFVLLW 910
|
970
....*....|....*..
gi 24648586 934 VFYVVICILEAYDVIRV 950
Cdd:TIGR00845 911 LLYILFSSLEAYCHIKG 927
|
|
| Na_Ca_ex_C |
pfam16494 |
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ... |
300-417 |
1.38e-45 |
|
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.
Pssm-ID: 465141 Cd Length: 136 Bit Score: 160.16 E-value: 1.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 300 RRLLVYKYMDKNYRVNK-RGTVVAGEHD-------QVEMDAEKGPKQPMVTSARGN----DAEAFDEARREYITLLTELR 367
Cdd:pfam16494 1 RRLLFYKYLYKRYRADKrRGIIVETEGElgpkegiEMLMDGKLVGSHVMEGGAEGPvddpEAKELDEARREVIRILKELK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 24648586 368 QKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQE 417
Cdd:pfam16494 81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAA 130
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
441-529 |
1.44e-35 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 129.68 E-value: 1.44e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 441 PIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFE 520
Cdd:smart00237 1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80
|
....*....
gi 24648586 521 EDECFYIRL 529
Cdd:smart00237 81 KDETFYVRL 89
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
441-529 |
2.17e-33 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 123.51 E-value: 2.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 441 PIRMYFEPGHYTVMENCGEFEVRVVRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVF 519
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80
|
90
....*....|
gi 24648586 520 EEDECFYIRL 529
Cdd:pfam03160 81 EGDENFFVLL 90
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
554-643 |
3.00e-30 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 114.66 E-value: 3.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 554 AGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYE 633
Cdd:smart00237 1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80
|
90
....*....|
gi 24648586 634 KDVSFKVHIG 643
Cdd:smart00237 81 KDETFYVRLS 90
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
554-643 |
3.11e-26 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 103.10 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 554 AGIFAFTDSVFEITESVGRFELKVMRYSGA-RGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSY 632
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80
|
90
....*....|.
gi 24648586 633 EKDVSFKVHIG 643
Cdd:pfam03160 81 EGDENFFVLLS 91
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
777-942 |
3.44e-26 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 104.99 E-value: 3.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 777 GYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNVF 856
Cdd:pfam01699 2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 857 LGIGLAWTIAAVYHSSHGMTFNVEpgtIGFAVALFCGEALIAIMLIMFRRWHKGIGaelggpkvskyisaAILVFLWVFY 936
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLLKLDLG---VLLLVALLLLLLLLLLLLPLFGRLSRFEG--------------LVLLLLYIVY 143
|
....*.
gi 24648586 937 VVICIL 942
Cdd:pfam01699 144 LVFQIV 149
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
126-296 |
5.75e-18 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 81.49 E-value: 5.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 126 VYFVLLIYLFVGVSIIADRFMAAIEAITSIeravvvkgpnntkqvmhvRIWNETVANLTLMALGSSAPEILLSVIEIYAK 205
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARV------------------LGISGTVLGLTILALGTSLPELVSSIIAALRG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 206 dfeSGDLGPGTIVGSAAYNLFMIIAVCMI--WIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILsvftPGVILVWEAIV 283
Cdd:pfam01699 63 ---EPDLALGNVIGSNIFNILLVLGLSALigPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135
|
170
....*....|...
gi 24648586 284 TLLFFPLTVLWAY 296
Cdd:pfam01699 136 LLLLYIVYLVFQI 148
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
785-939 |
2.75e-13 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 71.32 E-value: 2.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 785 IFVIGVITAIIG-----DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAA--KHDEGAdncIGNVTGSNAVNVFL 857
Cdd:COG0530 156 LLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAArkGEDDLA---VGNIIGSNIFNILL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 858 GIGLAWTIAavyhsshgmtfnvePGTIGFAVALF--CGEALIAIMLIMFRRWHKGIGAelggpkvskyISAAILVFLWVF 935
Cdd:COG0530 233 VLGIGALIT--------------PIPVDPAVLSFdlPVMLAATLLLLGLLRTGGRIGR----------WEGLLLLALYLA 288
|
....
gi 24648586 936 YVVI 939
Cdd:COG0530 289 YLAL 292
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
111-358 |
7.05e-11 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 66.56 E-value: 7.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 111 PQRNISVGDRLvRGFVYFVL--LIYLFVGVSIIADR-FMAAIEAITsieravvvkgpnNTKQVmhvriwNETVANLTLMA 187
Cdd:TIGR00927 443 PPDLFSVEERR-QGWVVLHIfgMMYVFVALAIVCDEyFVPALGVIT------------DKLQI------SEDVAGATFMA 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 188 LGSSAPEILLSVIEIYakdFESGDLGPGTIVGSAAYNLFMIIAVCMIWipageVRRIRHLRVFFVTALFSVFAYVWLWLI 267
Cdd:TIGR00927 504 AGGSAPELFTSLIGVF---ISHSNVGIGTIVGSAVFNILFVIGTCALF-----SREILNLTWWPLFRDVSFYILDLMMLI 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 268 LsVFTPGVILVWEAIVTLL---FFPLTVLWAYIAErrLLVYKYMDKN--YRVNKRGTVVAGEHDQVEMDAEKGP---KQP 339
Cdd:TIGR00927 576 L-FFLDSLIAWWESLLLLLayaLYVFTMKWNKQIE--LWVKEQLSRRpvAKVMALGDLSKGDVAEAEHTGERTGeegERP 652
|
250
....*....|....*....
gi 24648586 340 MVTSARgNDAEAFDEARRE 358
Cdd:TIGR00927 653 TEAEGE-NGEESGGEAEQE 670
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
779-907 |
1.07e-09 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 60.80 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 779 VTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGaDNCIGNVTGSNAVNVFLG 858
Cdd:TIGR00367 173 VLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLG-DIAVGNVIGSNIFNILVG 251
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 24648586 859 IGLAWTIAAVYHSSHGMTFNvepGTIGFAVALFCgeALIAIMLIMFRRW 907
Cdd:TIGR00367 252 LGVPSLFMPIPVEPLAYNLD---APVMVIVTLLL--MLFFKTSMKLGRW 295
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
797-944 |
1.20e-09 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 60.53 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 797 DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNVFLGIGLAWTIAavyhsshgmT 876
Cdd:COG0530 6 RGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILGLAALIR---------P 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648586 877 FNVEPGTIGFAVALFCGEALIAIMLIMFRRWhkgigaelggpkvsKYISAAILVFLWVFYVVICILEA 944
Cdd:COG0530 76 LAVDRRVLRRDLPFLLLASLLLLALLLDGTL--------------SRIDGVILLLLYVLYLYYLIRRA 129
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
178-301 |
1.26e-09 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 60.53 E-value: 1.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 178 ETVANLTLMALGSSAPEILLSVIEIYakdFESGDLGPGTIVGSAAYNLFMIIAVCMIwipageVRRIR-HLRVFFVTALF 256
Cdd:COG0530 19 PLVIGLTIVAFGTSLPELAVSVTAAL---DGSPDIAVGNVVGSNIANILLILGLAAL------IRPLAvDRRVLRRDLPF 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 24648586 257 SVFAYVWLWLilsVFTPGVILVWEAIVTLLFFPLTVLWAYIAERR 301
Cdd:COG0530 90 LLLASLLLLA---LLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
782-868 |
4.52e-06 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 49.63 E-value: 4.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 782 VVSIFVIGVITAIIG-----DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHdEGADNCIGNVTGSNAVNVF 856
Cdd:TIGR00367 3 LIGYLILGLILLIYGadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLM-GQPDIGVGNVIGSNIFNIL 81
|
90
....*....|..
gi 24648586 857 LGIGLAWTIAAV 868
Cdd:TIGR00367 82 LILGLSAIFSPI 93
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
180-288 |
5.12e-06 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 49.63 E-value: 5.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 180 VANLTLMALGSSAPEILLSVIEIYAkdfESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAgEVRRIRHLRVFFVTALFSVF 259
Cdd:TIGR00367 38 IIGVTVVAIGTSLPELFTSLIASLM---GQPDIGVGNVIGSNIFNILLILGLSAIFSPI-IVDKDWLRRDILFYLLVSIL 113
|
90 100
....*....|....*....|....*....
gi 24648586 260 AYVWLWLILSVFTPGVILVWEAIVTLLFF 288
Cdd:TIGR00367 114 LLFFGLDGQISRIDGVVLLILYIVYLLFL 142
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
176-294 |
6.53e-06 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 48.98 E-value: 6.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 176 WNETVANLTLMALGSSAPEILLSVIEIYAKDfesGDLGPGTIVGSAAYNLFMIIAVCMIWIPaGEVRRIRHLRVFFVTAL 255
Cdd:COG0530 184 VSELVIGLTIVAIGTSLPELATSIVAARKGE---DDLAVGNIIGSNIFNILLVLGIGALITP-IPVDPAVLSFDLPVMLA 259
|
90 100 110
....*....|....*....|....*....|....*....
gi 24648586 256 FSVFayvwlwLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
Cdd:COG0530 260 ATLL------LLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
781-862 |
2.96e-04 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 43.87 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 781 FVVSIFVIGVITAIIGD-----AASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNV 855
Cdd:PRK10734 3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNI 81
|
....*..
gi 24648586 856 FLGIGLA 862
Cdd:PRK10734 82 LLILGLA 88
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
178-288 |
2.54e-03 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 41.16 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648586 178 ETVANLTLMALGSSAPEILLSVIEIYAKDfesGDLGPGTIVGSAAYNLFMIIAVCMIwipagevrrIRHLRVFFVTALF- 256
Cdd:TIGR00367 204 EKIIGLTLLAIGTSLPELVVSLAAARKGL---GDIAVGNVIGSNIFNILVGLGVPSL---------FMPIPVEPLAYNLd 271
|
90 100 110
....*....|....*....|....*....|...
gi 24648586 257 -SVFAYVWLWLILSVFTPGVILVWEAIVTLLFF 288
Cdd:TIGR00367 272 aPVMVIVTLLLMLFFKTSMKLGRWEGILLLALY 304
|
|
| |
