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Conserved domains on  [gi|24649526|ref|NP_732948|]
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phosphatidylserine decarboxylase, isoform B [Drosophila melanogaster]

Protein Classification

phosphatidylserine decarboxylase( domain architecture ID 999)

phosphatidylserine decarboxylase catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)

EC:  4.1.1.65
Gene Ontology:  GO:0004609|GO:0006646
PubMed:  27650064|9370338
SCOP:  4007787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PS_Dcarbxylase super family cl03656
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 61-441 8.60e-85

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


The actual alignment was detected with superfamily member PLN02938:

Pssm-ID: 470849  Cd Length: 428  Bit Score: 266.30  E-value: 8.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   61 PASKEAPLHHRRPQ-HKQQPNPSQELAQIRRNILSRWTGFLLRWAPMG-ICVFGAI-------EWQLQKNRcEKEGKPRT 131
Cdd:PLN02938   4 RVSSKLPLLARYSLlRHQHHHQSSRASVNGGSGSSQGNSFLLPGATVAtLLMLGALharrlyeDKKVEEAR-EKGIEPEF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  132 ASELQSRIYCSLPLRIISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPeYEHYNSLAEFFTRPLKEGVRVIDQ 211
Cdd:PLN02938  83 SPDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  212 QAP-LVSPADGKVLHFG--SASDSLIEQVKGVSYSIEDFLG--PLETVEQANSGASYAQALKKKSDGS------------ 274
Cdd:PLN02938 162 DPNcLVSPVDGIVLRFGelKGPGTMIEQVKGFSYSVSALLGanSLLPMTAEGKEEKEEETLKDKSSKSwlrvslaspklr 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  275 --------TELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTA 346
Cdd:PLN02938 242 dpvsaspmKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  347 VGATNVGSVEIYMDADLKTNRWTGFNVGKHPPSTYEYDELVLNKELTeapkefgKGDLVGQFNMGSTIVLLFEAP----- 421
Cdd:PLN02938 322 VGATNIGSIELFIEPELRTNRPKKKIFNSEPPEERVYEPEGCGLCLK-------KGDEVAVFNLGSTVVLVFEAPvevep 394

                        410       420
                 ....*....|....*....|....*....
gi 24649526  422 ---------KNFKFDIIAGQKIRVGESLG 441
Cdd:PLN02938 395 lfkvldqssSDFRFCVRKGDRIRVGQALG 423
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 61-441 8.60e-85

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 266.30  E-value: 8.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   61 PASKEAPLHHRRPQ-HKQQPNPSQELAQIRRNILSRWTGFLLRWAPMG-ICVFGAI-------EWQLQKNRcEKEGKPRT 131
Cdd:PLN02938   4 RVSSKLPLLARYSLlRHQHHHQSSRASVNGGSGSSQGNSFLLPGATVAtLLMLGALharrlyeDKKVEEAR-EKGIEPEF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  132 ASELQSRIYCSLPLRIISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPeYEHYNSLAEFFTRPLKEGVRVIDQ 211
Cdd:PLN02938  83 SPDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  212 QAP-LVSPADGKVLHFG--SASDSLIEQVKGVSYSIEDFLG--PLETVEQANSGASYAQALKKKSDGS------------ 274
Cdd:PLN02938 162 DPNcLVSPVDGIVLRFGelKGPGTMIEQVKGFSYSVSALLGanSLLPMTAEGKEEKEEETLKDKSSKSwlrvslaspklr 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  275 --------TELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTA 346
Cdd:PLN02938 242 dpvsaspmKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  347 VGATNVGSVEIYMDADLKTNRWTGFNVGKHPPSTYEYDELVLNKELTeapkefgKGDLVGQFNMGSTIVLLFEAP----- 421
Cdd:PLN02938 322 VGATNIGSIELFIEPELRTNRPKKKIFNSEPPEERVYEPEGCGLCLK-------KGDEVAVFNLGSTVVLVFEAPvevep 394

                        410       420
                 ....*....|....*....|....*....
gi 24649526  422 ---------KNFKFDIIAGQKIRVGESLG 441
Cdd:PLN02938 395 lfkvldqssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 194-442 3.78e-66

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 210.21  E-value: 3.78e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   194 LAEFFTRPLKEGVRVIDQ-QAPLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGPletveqansgasyaqalkKKSD 272
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPAgPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGD------------------DKLD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   273 GSTELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTAVGATNV 352
Cdd:pfam02666  63 KFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGALNV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   353 GSVEIYMdadlktnrwtgfnvgkhppstyeydelvlnkeltEAPKEFGKGDLVGQFNMGSTIVLLFEAPKNFKFDIIAGQ 432
Cdd:pfam02666 143 GSIVLTV----------------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQ 188

                         250
                  ....*....|
gi 24649526   433 KIRVGESLGH 442
Cdd:pfam02666 189 KVKAGETIGA 198
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 180-443 2.73e-63

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 204.29  E-value: 2.73e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   180 LSEAMYPEYEHYNSLAEFFTRPLKEGVRVIDQQA-PLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGPL-ETVEQA 257
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDKEPnALVSPADGVISEVGIINPNQILQVKGMDYSLEELLGEKnPLSPYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   258 NSGASYAqalkkksdgstelyqcVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQW 337
Cdd:TIGR00163  81 RNGGFFV----------------VTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVFDT 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   338 KHGFFSYTAVGATNVGSVEIYMDADLKTNRWTGFNvgkhppSTYEYDelvlnkelTEAPKEFGKGDLVGQFNMGSTIVLL 417
Cdd:TIGR00163 145 EFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHEFT------QTWTYN--------ALGPVKLLKGEEMGYFELGSTVILL 210

                         250       260
                  ....*....|....*....|....*..
gi 24649526   418 FEA-PKNFKFDIIAGQKIRVGESLGHI 443
Cdd:TIGR00163 211 FEAdAFQLSAHLAVGQEVKIGELLAYE 237
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 144-444 5.28e-54

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 180.44  E-value: 5.28e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526 144 PLRIISRCWGWLAACYLPPSLRpyVYGWYSNTFDVNLSEAmypEYEHYNSLAEFFTRPLKEGVRVIDQQA-PLVSPADGK 222
Cdd:COG0688   1 PKHLLSRLMGPIAREGWPFIAL--LIRTFIKRYGIDLSEA---LPSSYTSFNDFFFRDLKPGARPIPDDPdAVVSPADGK 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526 223 VLHFGSASDSLIEQVKGVSYSIEDFLGPLETVEQANSGasyaqalkkksdgstelYQCVIYLAPGDYHRFHSPTAWKPTI 302
Cdd:COG0688  76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEKFEGG-----------------TFVSIFLSPFDYHRNHMPVDGTVVE 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526 303 RRHFSGELLSVSPKVAGwlPGLFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIYmdadlktnrwtgfnvgkhppstye 382
Cdd:COG0688 139 VKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTY------------------------ 192

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24649526 383 ydelvlnkelTEAPKEFGKGDLVGQFNMGSTIVLLFEaPKNFKFDIIAGQKIRVGESLGHIV 444
Cdd:COG0688 193 ----------VKEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRLK 243
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 61-441 8.60e-85

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 266.30  E-value: 8.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   61 PASKEAPLHHRRPQ-HKQQPNPSQELAQIRRNILSRWTGFLLRWAPMG-ICVFGAI-------EWQLQKNRcEKEGKPRT 131
Cdd:PLN02938   4 RVSSKLPLLARYSLlRHQHHHQSSRASVNGGSGSSQGNSFLLPGATVAtLLMLGALharrlyeDKKVEEAR-EKGIEPEF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  132 ASELQSRIYCSLPLRIISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPeYEHYNSLAEFFTRPLKEGVRVIDQ 211
Cdd:PLN02938  83 SPDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  212 QAP-LVSPADGKVLHFG--SASDSLIEQVKGVSYSIEDFLG--PLETVEQANSGASYAQALKKKSDGS------------ 274
Cdd:PLN02938 162 DPNcLVSPVDGIVLRFGelKGPGTMIEQVKGFSYSVSALLGanSLLPMTAEGKEEKEEETLKDKSSKSwlrvslaspklr 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  275 --------TELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTA 346
Cdd:PLN02938 242 dpvsaspmKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  347 VGATNVGSVEIYMDADLKTNRWTGFNVGKHPPSTYEYDELVLNKELTeapkefgKGDLVGQFNMGSTIVLLFEAP----- 421
Cdd:PLN02938 322 VGATNIGSIELFIEPELRTNRPKKKIFNSEPPEERVYEPEGCGLCLK-------KGDEVAVFNLGSTVVLVFEAPvevep 394

                        410       420
                 ....*....|....*....|....*....
gi 24649526  422 ---------KNFKFDIIAGQKIRVGESLG 441
Cdd:PLN02938 395 lfkvldqssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 194-442 3.78e-66

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 210.21  E-value: 3.78e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   194 LAEFFTRPLKEGVRVIDQ-QAPLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGPletveqansgasyaqalkKKSD 272
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPAgPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGD------------------DKLD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   273 GSTELYQCVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTAVGATNV 352
Cdd:pfam02666  63 KFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGALNV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   353 GSVEIYMdadlktnrwtgfnvgkhppstyeydelvlnkeltEAPKEFGKGDLVGQFNMGSTIVLLFEAPKNFKFDIIAGQ 432
Cdd:pfam02666 143 GSIVLTV----------------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQ 188

                         250
                  ....*....|
gi 24649526   433 KIRVGESLGH 442
Cdd:pfam02666 189 KVKAGETIGA 198
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 180-443 2.73e-63

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 204.29  E-value: 2.73e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   180 LSEAMYPEYEHYNSLAEFFTRPLKEGVRVIDQQA-PLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGPL-ETVEQA 257
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDKEPnALVSPADGVISEVGIINPNQILQVKGMDYSLEELLGEKnPLSPYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   258 NSGASYAqalkkksdgstelyqcVIYLAPGDYHRFHSPTAWKPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQW 337
Cdd:TIGR00163  81 RNGGFFV----------------VTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVFDT 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526   338 KHGFFSYTAVGATNVGSVEIYMDADLKTNRWTGFNvgkhppSTYEYDelvlnkelTEAPKEFGKGDLVGQFNMGSTIVLL 417
Cdd:TIGR00163 145 EFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHEFT------QTWTYN--------ALGPVKLLKGEEMGYFELGSTVILL 210

                         250       260
                  ....*....|....*....|....*..
gi 24649526   418 FEA-PKNFKFDIIAGQKIRVGESLGHI 443
Cdd:TIGR00163 211 FEAdAFQLSAHLAVGQEVKIGELLAYE 237
PTZ00403 PTZ00403
phosphatidylserine decarboxylase; Provisional
 146-443 1.46e-61

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 173594  Cd Length: 353  Bit Score: 203.93  E-value: 1.46e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  146 RIISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEAMYPeYEHYNSLAEFFTRPLKEGVRVIDQ--QAPLVSPADGKV 223
Cdd:PTZ00403  63 RTRSRITGSIFNIEIPNTYRLPIYNFLIKYMGINKEEIKYP-IESYKSIGDFFSRYIREETRPIGDvsDYSIVSPCDSEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  224 LHFGSASDSLIEQVKGVSYSIEDFLGpletveqansgasyAQALKKKSDGSTELYQCVIYLAPGDYHRFHSPTAWKPTIR 303
Cdd:PTZ00403 142 TDYGELSSEYLENVKGVKFNVNTFLG--------------SDMQKKYNDGSTKFFYAIFYLSPKKYHHFHAPFNFKYKIR 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  304 RHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIYMDADLKTNRWtgfnvgKHPPSTYEY 383
Cdd:PTZ00403 208 RHISGELFPVFQGMFKIINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNL------RTQLSYMGG 281

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  384 DelvLNKELTEAPKEFGKGDLVGQFNMGSTIVLLFEAPKNFKFDIIAGQKIRVGESLGHI 443
Cdd:PTZ00403 282 D---INTKIYDSYKSVEVGDEVGEFRMGSSIVVIFENKKNFSWNVKPNQTVSVGQRLGGV 338
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 144-444 5.28e-54

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 180.44  E-value: 5.28e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526 144 PLRIISRCWGWLAACYLPPSLRpyVYGWYSNTFDVNLSEAmypEYEHYNSLAEFFTRPLKEGVRVIDQQA-PLVSPADGK 222
Cdd:COG0688   1 PKHLLSRLMGPIAREGWPFIAL--LIRTFIKRYGIDLSEA---LPSSYTSFNDFFFRDLKPGARPIPDDPdAVVSPADGK 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526 223 VLHFGSASDSLIEQVKGVSYSIEDFLGPLETVEQANSGasyaqalkkksdgstelYQCVIYLAPGDYHRFHSPTAWKPTI 302
Cdd:COG0688  76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEKFEGG-----------------TFVSIFLSPFDYHRNHMPVDGTVVE 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526 303 RRHFSGELLSVSPKVAGwlPGLFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIYmdadlktnrwtgfnvgkhppstye 382
Cdd:COG0688 139 VKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTY------------------------ 192

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24649526 383 ydelvlnkelTEAPKEFGKGDLVGQFNMGSTIVLLFEaPKNFKFDIIAGQKIRVGESLGHIV 444
Cdd:COG0688 193 ----------VKEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRLK 243
PRK03934 PRK03934
phosphatidylserine decarboxylase; Provisional
 146-443 6.14e-54

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 235177 [Multi-domain]  Cd Length: 265  Bit Score: 180.91  E-value: 6.14e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  146 RIISRCWGWLAACYLPPSLRPYVYGWYSNTFDVNLSEamYPEYEHYNSLAEFFTRPLKEGvRVIDQ-QAPLVSPADGKVL 224
Cdd:PRK03934   5 NALSRIFGKFAGYKFPKFIQKFINASYVKIFKIDMSE--FKPPENYKSLNALFTRSLKKP-REFDEdPNIFISPCDSLIT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  225 HFGSASDSLIEQVKGVSYSIEDFLGplETVEQANSGASYAQalkkksdgstelyqcvIYLAPGDYHRFHSPTAWKPTIRR 304
Cdd:PRK03934  82 ECGSLEEDKALQIKGMEYSIEELLG--ESNSELVNGFDYIN----------------FYLSPKDYHRYHAPCDLEILEAR 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  305 HFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHG-FFSYTAVGATNVGSVEIYMDADLKTNRWTGFnvgkhpPSTYEY 383
Cdd:PRK03934 144 YIPGKLYPVNLPSLEKNKNLFVKNERVVLKCKDKKGkRLYFVFVGALNVGKMRFNFDERIQTNAKARF------IQTYEY 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  384 DELVLNkelteapkefgKGDLVGQFNMGSTIVLLFEaPKNFKFDIIAGQKIRVGESLGHI 443
Cdd:PRK03934 218 ENLKLK-----------KGEELGNFEMGSTIVLFSQ-KGSLEFNLKAGKSVKFGESIGEI 265
psd PRK00044
phosphatidylserine decarboxylase; Reviewed
 143-444 1.90e-53

phosphatidylserine decarboxylase; Reviewed


Pssm-ID: 234591  Cd Length: 288  Bit Score: 180.41  E-value: 1.90e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  143 LPLRIISRCWGWLAACYLPpSLRPYVYGWYSNTFDVNLSEAMYPEYEHYNSLAEFFTRPLKEGVRVIDqQAP--LVSPAD 220
Cdd:PRK00044  13 LPKHLLTRLAGWLASSRAG-WLTTAVIRLFIKKYKVDMSEAQKPDPAAYKTFNDFFTRALKDGARPID-EDPnaLVSPAD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  221 GKVLHFGSASDSLIEQVKGVSYSIEDFLGpletvEQANSGASYAqalkkksDGS--TelyqcvIYLAPGDYHRFHSPtaW 298
Cdd:PRK00044  91 GAISQLGPIEDGQIFQAKGHSYSLEALLG-----GDAALADPFR-------NGSfaT------IYLSPRDYHRVHMP--C 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  299 KPTIRR--HFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIYmdadlktnrWTG-FNvgk 375
Cdd:PRK00044 151 DGTLREmiYVPGDLFSVNPLTARNVPNLFARNERVVCLFDTEFGPMAQVLVGATIVGSIETV---------WAGtVT--- 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24649526  376 hPP-----STYEYDelvlnkELTEAPKEFGKGDLVGQFNMGSTIVLLFeAPKNFKFD--IIAGQKIRVGESLGHIV 444
Cdd:PRK00044 219 -PPregiiKRWDYP------EAGDGAITLKKGAEMGRFKLGSTVINLF-PPGKVQLAeqLQAGSVVRMGQPLAHIT 286
PRK00723 PRK00723
phosphatidylserine decarboxylase; Provisional
 146-446 2.90e-33

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179097 [Multi-domain]  Cd Length: 297  Bit Score: 126.96  E-value: 2.90e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  146 RIISRCWGWLaaCYLPPS---LRPYVygwysNTFDVNLSEAMYPeYEHYNSLAEFFTRPLKEGVRVIDQ-QAPLVSPADG 221
Cdd:PRK00723  43 KIFSKIYGWY--CDSRLSrkkIKPFV-----NDFNIDMSESEKP-LSDFKSFNDFFTRKLKPEARPIDQgENILISPGDG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  222 KVLHFGSASDSLIEQVKGVSYSIEDFLGPLETVEQansgasYAqalkkksDGStelyqCVIY-LAPGDYHRFHSPTAWKP 300
Cdd:PRK00723 115 RLLAYENIDLNSLFQVKGKTYSLKELLGDPELAKK------YA-------GGT-----CLILrLCPTDYHRFHFPDSGIC 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  301 TIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKH-GFFSYTAVGATNVGSVEiymdadlktnrwtgfnvgkhppS 379
Cdd:PRK00723 177 EETRKIKGHYYSVNPIALKKIFELFCENKREWSIFKSENfGDILYVEVGATCVGSII----------------------Q 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24649526  380 TYEYDELVlnkelteapkefGKGDLVGQFNM-GSTIVLLFEaPKNFKF--DIIAGQ------KIRVGESLGHIVGS 446
Cdd:PRK00723 235 TYKPNKKV------------KKGDEKGYFKFgGSTVILFFE-KNKIKIdaDILEQSklgyetKVLMGESIGRKFSS 297
PRK03140 PRK03140
phosphatidylserine decarboxylase; Provisional
 172-443 1.11e-30

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179544 [Multi-domain]  Cd Length: 259  Bit Score: 118.94  E-value: 1.11e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  172 YSNTFDVNLSEAMYPEYEhYNSLAEFFTRPLKEGVRVIDQQA-PLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGP 250
Cdd:PRK03140  38 YAKVYQINQDEMEKGLKE-YRTLHELFTRKLKEGKRPIDTDAsSIVSPVDGVFADVGPIEDDKTFDVKGKRYSIAEMLGN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  251 LETVEQANSGasyaqalkkksdgstelYQCVIYLAPGDYHRFHSPTAwkPTIRRHFsgELLSVSPKV--AGWLPGLFCL- 327
Cdd:PRK03140 117 EERAQRYAGG-----------------TYMVLYLSPSHYHRIHSPIS--GTVTEQF--VLGRKSYPVnaLGLEYGKRPLs 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  328 -NERVLYMGQWKHGFFSYTAVGATNVGSVEIymdadlktnrwtgfnvgkhppsTYEYDELVlnkelteapkefgKGDLVG 406
Cdd:PRK03140 176 kNYRSVTEVNSDGEHMALVKVGAMFVNSIEL----------------------THERDTVQ-------------KGEEMA 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 24649526  407 QFNMGSTIVLLFEapKN-FKFD--IIAGQKIRVGESLGHI 443
Cdd:PRK03140 221 YFSFGSTVVLLFE--KDmIEPDqeLKSGQEVRLGEKIGTR 258
PRK09629 PRK09629
bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional
 143-441 3.08e-29

bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional


Pssm-ID: 104071 [Multi-domain]  Cd Length: 610  Bit Score: 120.61  E-value: 3.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  143 LPLRIISRCWGWLAACYLPpSLRPYVYGWYSNTFDVNLSEAMYPE---YEHYNSlaeFFTRPLKEGVRVIDQQ-APLVSP 218
Cdd:PRK09629 336 LPHHLLSRLAGCVAECRVR-WFKNAFTAWFARRYQVDMSQALVEDltsYEHFNA---FFTRALKADARPLDTTpGAILSP 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  219 ADGKVLHFGSASDSLIEQVKGVSYSIEDFLGPLETVEQANSGASYAqalkkksdgstelyqcVIYLAPGDYHRFHSPTAW 298
Cdd:PRK09629 412 ADGAISQLGPIDHGRIFQAKGHSFSVLELLGGDPKLSAPFMGGEFA----------------TVYLSPKDYHRVHMPLAG 475

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  299 KPTIRRHFSGELLSVSPKVAGWLPGLFCLNERVLYMGQWKHGFFSYTAVGATNVGSVEIYmdadlktnrWTGFNVgkhPP 378
Cdd:PRK09629 476 TLREMVYVPGRIFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASVETV---------WAGLVT---PP 543

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24649526  379 ----STYEYDelvlnkELTEAPKEFGKGDLVGQFNMGSTIVLLFeAPKNFKF--DIIAGQKIRVGESLG 441
Cdd:PRK09629 544 krelKTFSYD------EAARAPIHLEKGAEMGRFKLGSTAIVLF-GPNQVKWaeQLTAGSKVQMGQALA 605
PLN02964 PLN02964
phosphatidylserine decarboxylase
 178-355 2.44e-17

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 84.53  E-value: 2.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  178 VNLSEAMYPeYEHYNSLAEFFTRPLKEGVRVI---DQQAPLVSPADGKVLHFGSASDSLIEQVKGVSYSIEDFLGpletv 254
Cdd:PLN02964 401 INMDEVKYP-LEHFKTFNEFFIRELKPGARPIacmDNDDVAVCAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLG----- 474

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649526  255 EQANSgasyaqalKKKSDGSTELYQcviyLAPGDYHRFHSPTAwkPTIRR--HFSGELLSVSP-KVAGWLPGLFCLNERV 331
Cdd:PLN02964 475 KKVHS--------DAFLDGSLVIFR----LAPQDYHRFHVPVS--GVIEKfvDVPGSLYTVNPiAVNSKYCNVFTENKRA 540

                        170       180
                 ....*....|....*....|....*
gi 24649526  332 LYMGQWKH-GFFSYTAVGATNVGSV 355
Cdd:PLN02964 541 VCIISTAEfGKVAFVAIGATMVGSI 565
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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