Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281362588   517 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 560
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362588   562 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 603
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 281362588 156 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 186
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281362588  327 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 362
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362588   196 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 228
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362588   364 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 394
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281362588  582 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 628
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281362588   517 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 560
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362588   562 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 603
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....
gi 281362588  31 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 64
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 281362588  236 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 272
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 281362588 156 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 186
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 281362588  72 CSPDEYACKSGegQCVPLAWMCDQSKDCSDGSDEHNC 108
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362588  155 AEHTCTNGACIAKRWVCDGDPDCSDGSDERSC 186
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 281362588    71 TCSPDEYACKSGegQCVPLAWMCDQSKDCSDGSDE 105
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20
                   ....*....|....*....|....*....
gi 281362588   289 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 317
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362588   196 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 228
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 281362588  194 TPCLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 233
Cdd:pfam00057   1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDE--ENC 37

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362588   364 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 394
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 281362588 364 DINECEVPGKCS--QICVNEIGGFKCECEAGYM 394
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362588  364 DINECEVPGK-CSQ--ICVNEIGGFKCECEAG 392
Cdd:pfam07645   1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281362588   517 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 560
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362588   562 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 603
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....
gi 281362588  31 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 64
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 281362588  236 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 272
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 281362588 156 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 186
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 281362588  72 CSPDEYACKSGegQCVPLAWMCDQSKDCSDGSDEHNC 108
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362588  155 AEHTCTNGACIAKRWVCDGDPDCSDGSDERSC 186
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 281362588    71 TCSPDEYACKSGegQCVPLAWMCDQSKDCSDGSDE 105
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20
                   ....*....|....*....|....*....
gi 281362588   289 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 317
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362588   196 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 228
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 281362588  194 TPCLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 233
Cdd:pfam00057   1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDE--ENC 37

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362588   364 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 394
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                          10        20
                  ....*....|....*....|..
gi 281362588  346 HCECHEGYKLSPDKRNCQDINE 367
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22

Low-density lipoprotein receptor domain class A;

                          10        20
                  ....*....|....*....|....*....
gi 281362588  289 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 317
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281362588  582 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 628
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42