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Conserved domains on  [gi|25141341|ref|NP_740804|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 56-411 2.78e-48

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 171.26  E-value: 2.78e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  56 RRLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQI 135
Cdd:cd17318  81 EKYGAKRVLGYSILITALLTLLTPLAARG--GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 136 GIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpy 215
Cdd:cd17318 159 GTVIAMPLSGFLCESL---GWPSIFYIFGGLGLLWCLLW----------------------------------------- 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 216 mkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKV-NATA 294
Cdd:cd17318 195 --FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTT 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 295 VTKVSNAIASFASAIFIVIAAYGPFDSAELVqLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAP 374
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAV-VFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISP 351

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 25141341 375 IVIGRITSHG-TIYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:cd17318 352 LIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 56-411 2.78e-48

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 171.26  E-value: 2.78e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  56 RRLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQI 135
Cdd:cd17318  81 EKYGAKRVLGYSILITALLTLLTPLAARG--GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 136 GIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpy 215
Cdd:cd17318 159 GTVIAMPLSGFLCESL---GWPSIFYIFGGLGLLWCLLW----------------------------------------- 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 216 mkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKV-NATA 294
Cdd:cd17318 195 --FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTT 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 295 VTKVSNAIASFASAIFIVIAAYGPFDSAELVqLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAP 374
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAV-VFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISP 351

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 25141341 375 IVIGRITSHG-TIYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:cd17318 352 LIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 57-418 5.57e-41

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 152.98  E-value: 5.57e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    57 RLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:TIGR00894 102 KYVFKWSIGIGMFLSSVISIVIPWAAGGGIAL--VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   137 IAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRNRAETivRATPYM 216
Cdd:TIGR00894 180 TFIFLPISGWLCESWG--GWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTR--QSLPIK 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   217 KIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNA-TAV 295
Cdd:TIGR00894 256 AIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSlTAA 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   296 TKVSNAIASFASAIFIViaaYGPFDSAELVQLSIIVSMA-AFSAY-VPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLA 373
Cdd:TIGR00894 336 RKIFNGIGGLGPGIFAY---ALPYLSAAFYLTIIILTLAnAVSSGpLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIA 412

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 25141341   374 PIVIGRITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFGHGRTEPW 418
Cdd:TIGR00894 413 STLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDW 457
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
28-411 1.86e-27

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 113.04  E-value: 1.86e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIP 107
Cdd:COG2271  46 QLGLLASAFFLGYALGQIPAGL----LADRFGRRRVLAIGLLLWGLATLLFGFA----TSFWQLLLLRFLLGLGEAGFFP 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpresky 187
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWRAAFLILGLPGLLLALLR------------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 188 itateltyikggkqrrnraetivratpymkiilngcVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLP 267
Cdd:COG2271 182 ------------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 268 FFIQMITKLLFAIIADKVKQRKVNATavtkvsnAIASFASAIFIVIAAYgpFDSAELVQLSIIVSMAAFSAYVPGYNTSI 347
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRRRKLVL-------AIGLLLAALALLLLAL--LPSPALAIALLFLAGFGLGGAFGLLWALA 296

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141341 348 VTVAP-QFTAFISSYAQLYAQIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:COG2271 297 AELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
10-374 1.23e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.03  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    10 RSLPSPIPPLWTLQSIRFqTALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYF 89
Cdd:pfam07690  12 RSLLGPALPLLLAEDLGI-SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS----SLW 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    90 PVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAV 169
Cdd:pfam07690  87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   170 FLVIWHVRlaDKPRESKYITATELTYIKGGKQRRnraetIVRATPYMKIILngcvcaicaCSFAQSFVLVALVTYLPKYN 249
Cdd:pfam07690 164 AAVLLLLP--RPPPESKRPKPAEEARLSLIVAWK-----ALLRDPVLWLLL---------ALLLFGFAFFGLLTYLPLYQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   250 QIaFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVtkvsnaiaSFASAIFIVIAAYGPFDSAELVQLSI 329
Cdd:pfam07690 228 EV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--------LLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 25141341   330 IVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIASTLAP 374
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 56-411 2.78e-48

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 171.26  E-value: 2.78e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  56 RRLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQI 135
Cdd:cd17318  81 EKYGAKRVLGYSILITALLTLLTPLAARG--GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 136 GIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpy 215
Cdd:cd17318 159 GTVIAMPLSGFLCESL---GWPSIFYIFGGLGLLWCLLW----------------------------------------- 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 216 mkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKV-NATA 294
Cdd:cd17318 195 --FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTT 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 295 VTKVSNAIASFASAIFIVIAAYGPFDSAELVqLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAP 374
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAV-VFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISP 351

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 25141341 375 IVIGRITSHG-TIYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:cd17318 352 LIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 57-418 5.57e-41

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 152.98  E-value: 5.57e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    57 RLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:TIGR00894 102 KYVFKWSIGIGMFLSSVISIVIPWAAGGGIAL--VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   137 IAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRNRAETivRATPYM 216
Cdd:TIGR00894 180 TFIFLPISGWLCESWG--GWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTR--QSLPIK 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   217 KIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNA-TAV 295
Cdd:TIGR00894 256 AIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSlTAA 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   296 TKVSNAIASFASAIFIViaaYGPFDSAELVQLSIIVSMA-AFSAY-VPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLA 373
Cdd:TIGR00894 336 RKIFNGIGGLGPGIFAY---ALPYLSAAFYLTIIILTLAnAVSSGpLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIA 412

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 25141341   374 PIVIGRITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFGHGRTEPW 418
Cdd:TIGR00894 413 STLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDW 457
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 54-411 3.45e-30

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 121.81  E-value: 3.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd17381  88 LASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGY--LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGA 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 134 QIGIAVSMFLTAKLCqlhFFEGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivrat 213
Cdd:cd17381 166 QLGTVVSLPLSGLIC---YYLDWTYVFYIFGAVGLLWFFLW--------------------------------------- 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 214 pymkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKV-NA 292
Cdd:cd17381 204 ----IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNfST 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 293 TAVTKVSNAIASFASAIFIVIAAY-GPFDSAELVQLSIIVSMAAFSAyvPGYNTSIVTVAPQFTAFISSYAQLYAQIAST 371
Cdd:cd17381 280 VCVRKIFTLIGMIGPAVFLLAAGFtGCNYSLAVAFLTISSTLGGFSA--SGFNINHLDIAPSYAGILLGITNTFATIPGM 357

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 25141341 372 LAPIVIGRITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:cd17381 358 VGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
28-411 1.86e-27

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 113.04  E-value: 1.86e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIP 107
Cdd:COG2271  46 QLGLLASAFFLGYALGQIPAGL----LADRFGRRRVLAIGLLLWGLATLLFGFA----TSFWQLLLLRFLLGLGEAGFFP 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpresky 187
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWRAAFLILGLPGLLLALLR------------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 188 itateltyikggkqrrnraetivratpymkiilngcVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLP 267
Cdd:COG2271 182 ------------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 268 FFIQMITKLLFAIIADKVKQRKVNATavtkvsnAIASFASAIFIVIAAYgpFDSAELVQLSIIVSMAAFSAYVPGYNTSI 347
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRRRKLVL-------AIGLLLAALALLLLAL--LPSPALAIALLFLAGFGLGGAFGLLWALA 296

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141341 348 VTVAP-QFTAFISSYAQLYAQIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:COG2271 297 AELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
28-406 1.34e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 102.65  E-value: 1.34e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMaMVDivrRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIP 107
Cdd:COG2223  41 QLGLLFAIPVLVGALLRIPLGF-LVD---RFGPRRVLLIGLLLLGIGLLLLALAV----SYWLLLLLGLLLGIGGGGSFA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFFeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKY 187
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--IAAF-GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 188 ITATELtyikggkqrrnraetivraTPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLP 267
Cdd:COG2223 190 AAKASL-------------------RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 268 FFIQMITKLLFAIIADKVKQRKVnatavtkvsnAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSI 347
Cdd:COG2223 251 ALLGALGRPLGGWLSDRIGGRRV----------LLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 348 VTVAP-QFTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLI 406
Cdd:COG2223 321 PDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA--AFLVFAVLALVALVL 378
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 57-411 3.17e-23

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 100.71  E-value: 3.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17380  60 RFGGKKVLLLAVALWSLATLLTPLLAYS--SLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLG 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 137 IAVSMFLTAKLcqLHFFeGWPLVFIVYGLIGAVFLVIWHvrladkpresKYITAteltyikggkqrrnraetivratpym 216
Cdd:cd17380 138 TLLGGLIGPLL--LEYY-GWPSVFYFFGLLGLLWALVWL----------IYLPP-------------------------- 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 217 kiilngcVCAICACSFAQSFVLVALVTYLPKYNQIAFkMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVT 296
Cdd:cd17380 179 -------VWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVR 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 297 KVSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSayVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIV 376
Cdd:cd17380 251 KLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFS--SSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYL 328

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 25141341 377 IGRI-TSHGTiyeWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:cd17380 329 TGYIlEATGS---WSLVFVLAAVVNLVGAVVFLLFG 361
MFS_1 pfam07690
Major Facilitator Superfamily;
10-374 1.23e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.03  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    10 RSLPSPIPPLWTLQSIRFqTALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYF 89
Cdd:pfam07690  12 RSLLGPALPLLLAEDLGI-SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS----SLW 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    90 PVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAV 169
Cdd:pfam07690  87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   170 FLVIWHVRlaDKPRESKYITATELTYIKGGKQRRnraetIVRATPYMKIILngcvcaicaCSFAQSFVLVALVTYLPKYN 249
Cdd:pfam07690 164 AAVLLLLP--RPPPESKRPKPAEEARLSLIVAWK-----ALLRDPVLWLLL---------ALLLFGFAFFGLLTYLPLYQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   250 QIaFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVtkvsnaiaSFASAIFIVIAAYGPFDSAELVQLSI 329
Cdd:pfam07690 228 EV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--------LLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 25141341   330 IVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIASTLAP 374
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
27-373 5.19e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 91.19  E-value: 5.19e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVI 106
Cdd:COG2814  45 AQAGLVVTAYLLGAALGAPLAGR----LADRFGRRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGAGALF 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 107 PAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLadkpRESK 186
Cdd:COG2814 117 PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---GWRWVFLVNAVLALLALLLLLRLL----PESR 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 187 yitateltyikggKQRRNRAETIVRATPYMKIILngcvcAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSL 266
Cdd:COG2814 190 -------------PAARARLRGSLRELLRRPRLL-----LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 267 PFFIQMITKLLFAIIADKVKQRKVnatavtkvsnaIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTS 346
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRL-----------LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                       330       340
                ....*....|....*....|....*...
gi 25141341 347 IVTVAP-QFTAFISSYAQLYAQIASTLA 373
Cdd:COG2814 321 VAELAPpEARGRASGLYNSAFFLGGPLA 348
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 54-411 9.73e-20

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 90.86  E-value: 9.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd17382  72 IAAKFAANRVFGLAIFVTSTLNMLIPIAARV--HYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGS 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 134 QIGIAVSMFLTAKLCQlhfFEGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivrat 213
Cdd:cd17382 150 YAGAVVGMPLSGILVQ---YVGWSSPFYVYGVFGIIWYMFW--------------------------------------- 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 214 pymkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKV-KQRKVNA 292
Cdd:cd17382 188 ----MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLrSRGILST 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 293 TAVTKVSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSayVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTL 372
Cdd:cd17382 264 TAVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFA--ISGFNVNHLDIAPRYASILMGISNGIGTLSGMV 341

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 25141341 373 APIVIGRITSHGTIYEWKCAFYsLAGVLAVTGLIF-QIFG 411
Cdd:cd17382 342 CPVIVGALTKHKTREEWQYVFL-IASLVHFFGVIFyAIFA 380
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 54-407 4.29e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 89.02  E-value: 4.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd06174  54 LADRFGRRPVLLLGLLLFALGALLFAFAP----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFG 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 134 QIGIAVSMFLTAKLCqLHFFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGgkqrrnraetivraT 213
Cdd:cd06174 130 SVGGILGPLLGGILA-SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVL--------------K 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 214 PYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnat 293
Cdd:cd06174 195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP--- 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 294 avtkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLA 373
Cdd:cd06174 272 ------LLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345

                       330       340       350
                ....*....|....*....|....*....|....
gi 25141341 374 PIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLIF 407
Cdd:cd06174 346 PLLAGFLLAATFGLTG--AFLVLAVLLLLAAILL 377
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 54-406 1.26e-18

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 87.24  E-value: 1.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFsaiyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd17319  61 LLDRFGARKVLAVSMLLWSLFTALTGF----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGA 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 134 QIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLadkpreskyitateltyikggkqrrnraetivrat 213
Cdd:cd17319 137 PLGAAIGPPLSGWLLLLF---GWRWAFIIEGLLGLLLAVLWWFYL----------------------------------- 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 214 pymkiilnGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKqrKVNAT 293
Cdd:cd17319 179 --------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL--RGARR 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 294 AVtkvsnAIASFASAIFIVIAAYgPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQ-FTAFISSYAQLYAQIASTL 372
Cdd:cd17319 249 LV-----IIIGLLLAAVGLLLAY-LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFV 322

                       330       340       350
                ....*....|....*....|....*....|....
gi 25141341 373 APIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLI 406
Cdd:cd17319 323 APLLIGYLVDATGSYTA--AFLFLAAVALLAALL 354
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 57-407 1.21e-17

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 84.60  E-value: 1.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLsfalllnIFGSLLTPFSAIYLR---SYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd17475  57 RFGERRVL-------AVGLLLMGAAALLMAlvgSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGV 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 134 QIGIAV-SMFLTAklCQLHFfeGWPLVFIVYGLI---GAVFLVIWHVrladKPRESKYITATELTYIKGGKQ-RRNRAet 208
Cdd:cd17475 130 PLGGALaAALLPP--LALHY--GWRAAFVVAGLVsilAAVLFWLFYR----EPPAASAATESASTLLRSLKEvLRNRD-- 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 209 ivratpymkiilngcVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKV--K 286
Cdd:cd17475 200 ---------------VWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgG 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 287 QRKVnataVTKVSNAIASFASAIFIVIAAYGPFdsAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYA 366
Cdd:cd17475 265 RRRP----VLVITAAIAAAALLVLSLLSPGTPL--WLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTIN 338

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 25141341 367 QIASTLAPIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLIF 407
Cdd:cd17475 339 FIGIAIGPPLFGLLVDATHSYAP--AWLALALLLVLAALLL 377
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
26-411 2.79e-15

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 77.61  E-value: 2.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  26 RFQTALLISAACVVFGLmrtcFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFV 105
Cdd:COG2807  52 ATQAGLLTTLPLLAFGL----FAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGIAVG 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 106 IPAGSVLISSWFPlSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLADKPRes 185
Cdd:COG2807 124 NVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL---GWRGALAVWALLALLALLLWLPLLRRRPA-- 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 186 kyitateltyikggkqRRNRAETIVRATPYMKIILngcVCAICACSFAQSFVLVALVTYLPKYNQiAFKMNLTHNGIWSS 265
Cdd:COG2807 198 ----------------AAAAAPAAASLRSLWRSPL---AWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLS 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 266 LPFFIQMITKLLFAIIADKVKQRKVNATAVTkvsnAIASFASAIFIVIAAYGPFDSAELVQL----SIIVSMAAFSAYVP 341
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRLGDRRPLLLLLG----LLGLAGLLGLLLAPGSLPWLWAVLLGLgqggLFPLALTLIGLRAR 333

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 342 GyntsivtvaPQFTAFISSYAQLYAQIASTLAPIVIGRItsHGTIYEWKCAFYSLAGVLAVTGLIFQIFG 411
Cdd:COG2807 334 T---------PAEAAALSGMAQSVGYLLAALGPLLVGAL--HDATGSWTAALLLLAALAVLMLVAGLLAG 392
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-407 8.70e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 75.69  E-value: 8.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLsfalLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVI 106
Cdd:cd17325  31 AQIGLIVAAYALAQLLFSPPAGR----LSDRFGRKRLL----LLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 107 PAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAklcQLHFFEGWPLVFIVYGLIgAVFLVIWHVRLADKPRESK 186
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGG---LLADALGYRAPFLVCAAL-ALLALVLALLLLPEPRPPP 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 187 yitateltyikggkqRRNRAETIVRATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSL 266
Cdd:cd17325 179 ---------------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 267 PFFIQMITKLLFAIIADKVKQRKVnatavtkvsnAIASFAsAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTS 346
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPL----------ILIGLL-LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25141341 347 IVTVAPQFT-AFISSYAQLYAQIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIF 407
Cdd:cd17325 313 LADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLF 371
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 54-411 6.20e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 67.21  E-value: 6.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLL-NIFGSlltpfSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTG 132
Cdd:cd17473  58 LADRFGRKRLLIAGLLLyGIGGV-----AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 133 NQIGIAVSMFLTAKLCQLhffeGWPLVFIVYGLIGAVFLVIWHvrladkpreskyitateltYIKGGKQRRNRAETIVRA 212
Cdd:cd17473 133 MSLGGVVFLLLGGALAEI----GWRAPFLVYLLALPVLILVLL-------------------FLPEPARKSKSAASPGAA 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 213 TPymKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNA 292
Cdd:cd17473 190 TA--AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 293 TAVtkvsnaiASFASAIFIVIAAYGPFdsaeLVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIAST 371
Cdd:cd17473 268 IGF-------ALMALGFLLLALASGLW----VVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQF 336

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 25141341 372 LAPIVIGRITSHGTIYEwkCAFYSLAGVLAVTGLIFQIFG 411
Cdd:cd17473 337 LSPLVLGPLVNLTGGLS--GAFLILGVLALVLAIVLLLLR 374
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
27-412 6.46e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.19  E-value: 6.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVI 106
Cdd:COG0738  43 AQAGLLLFAFFLGYLLASLPAGR----LIDRFGYKRGLLLGLLLMALGLLLFALA----PSYPLLLLALFLLGLGLGLLD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 107 PAGSVLISSWFPLSeKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAV-FLVIWHVRLADKPRES 185
Cdd:COG0738 115 VAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLlALLFLRSKLPEIEEEE 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 186 kyitateltyikggkqrrnrAETIVRATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSS 265
Cdd:COG0738 194 --------------------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLS 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 266 LPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnaIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNT 345
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRL-----------LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFS 322

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25141341 346 SIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYewkcAFYSLAGVLAVTGLIFQIFGH 412
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLR----AAFLVPLVCYLLILLLALALK 385
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 31-393 8.22e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 66.63  E-value: 8.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    31 LLISAACVVFGLMRTCFGMAMvdivRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGS 110
Cdd:TIGR00881  34 LLLSSFSIAYGISKFVMGSVS----DRSNPRVFLPIGLILCAIVNLFFGFST----SLWVMAALWALNGIFQGMGWPPCG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   111 VLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPReSKYITA 190
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY--SWHWVFIVPGIIAIIVSLICFLLLRDSPQ-SCGLPP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   191 TELTYIKGGKQRRNRAETIVRATPYM--KIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPF 268
Cdd:TIGR00881 183 AEEMPNEEPDGDAEKKEEELTKKQIFlqYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYE 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   269 FIQMITKLLFAIIADKVKQRKVNATAVtkvsnaiaSFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIV 348
Cdd:TIGR00881 263 LGGLVGTLLAGWLSDKLFNGRRGPLAV--------FFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVI 334

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 25141341   349 TV--APQFTAFISS-YAQLYAQIASTLAPIVIGRITSHgtiYEWKCAF 393
Cdd:TIGR00881 335 ASelAPKKAAGTAAgFVGFFAYLGGILAGLPLGYLADG---FGWAGAF 379
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 27-316 9.00e-12

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 66.56  E-value: 9.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    27 FQTALLISAACVVFGLMRTCFGMaMVDivrRLGPKNLLSFALLLNIFGSLLTPFSAiylRSYFPVAAIRLIMGF-GYGFV 105
Cdd:TIGR00886  37 AQLGNLVAVPVLAGAVLRIILGF-LVD---IFGPRYTTALSLLLLAIPCLWAGLAV---QSYSVLLLIRLFIGIaGGSFA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   106 IpaGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFE---------GWPLVFIVYGLIGAVFLVIWHV 176
Cdd:TIGR00886 110 S--CMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGggqpahlawGWAFVIVPAGILLLPALLIFFV 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   177 RLADKPRESKYITATELTYIKGGKQRRnraeTIVRATPYMkiilngcvcaicaCSFAqsfVLVALVTYLPKYNQIAFKMN 256
Cdd:TIGR00886 188 GADTPPGKPATGKLSFKEALKVFGNRH----TWILALLYS-------------VTFG---SFLGVSSIFAMLFKDQFGLS 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   257 LTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVTKVSNAIA----------SFASAIFIVIAAY 316
Cdd:TIGR00886 248 KVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFlvvlglvsdgSLAAFIVLFVALF 317
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 16-407 3.54e-11

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 64.50  E-value: 3.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  16 IPPLWTLQSIRF-----QTALLISAACVVFGLMRTCFGMaMVDivrRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFP 90
Cdd:cd17478  15 LPALLPLLIAKLglsyaQAGLLVSVFSITSSLLQPLFGY-LAD---RKPRRYLLPLGPLLTGLGLSLLGFAP----NYWL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  91 VAAIRLIMGFGYGFVIPAGSVLISSWFPlSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIvygLIGAVF 170
Cdd:cd17478  87 LLLLVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI---IPGLAV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 171 LVIWHVRLADKPRESKyitateltyikggKQRRNRAETIVRATPYMKIILngcvcaICACSFAQSFVLVALVTYLPKYnQ 250
Cdd:cd17478 163 ALLLLRLRPLKKPEAK-------------KAAAKSSARSTLKGVWRALLL------LLIIVFLRSWVLSSLTTFLPFY-L 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 251 IAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnaiasFASAIFIVIAAYGPFDSAELVQLSII 330
Cdd:cd17478 223 VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV--------------IIASLLLAAPFLLLFLLTPGIWSYIL 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 331 VSMAAFSAYVPGYnTSIVTV---APQFTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEwkcAFYSLAgVLAVTGLIF 407
Cdd:cd17478 289 LVLAGFLLFASFP-VTVVLAqelLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLES---VLLILA-LLPLLGALL 363
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 27-410 2.06e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 62.20  E-value: 2.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVI 106
Cdd:cd17474  34 AQVGLLITAFTLPAAVLMPVAGV----LADRFGRKKVLLPGLLLFGIGGLLCGLSD----SFALLLAGRALQGIGAAGLG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 107 PAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLhffeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESK 186
Cdd:cd17474 106 PLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI----SWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 187 YITATELTyiKGGKQRRNRAETIVRATpymkiilngcvcaicacSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSL 266
Cdd:cd17474 182 SSSATKLR--DLKKALRGRGLLTFLVS-----------------AFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 267 PFFIQMITkllfAIIADKVKQRKVNATAVTKVSNAIASFASAIFiviaayGPFDSAELVQLSIIVSMAAFSAYVPGYNTS 346
Cdd:cd17474 243 WSVLLALG----SLFVGRLLKKRFGARRILVIGLLLYALSLLLL------GFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141341 347 IVTVAP-QFTAFISSYAQLYAQIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIFQIF 410
Cdd:cd17474 313 VTELAPeEERGTASSLYNFVRFLGQAVGPLLFGLLLEI---FGLSAPFLVGAAIALAAAVLLALL 374
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 57-378 8.15e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 57.37  E-value: 8.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341    57 RLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:TIGR00895  78 RIGRRRVLLWSILLFSVFTLLCALAT----NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   137 IAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWH-----------VRLADKPRESKYITATELTYIKGGKQRRNR 205
Cdd:TIGR00895 154 AAVGGFLAGWLIPVF---GWRSLFYVGGIAPLLLLLLLMrflpesidflvSKRPETVRRIVNAIAPQMQAEAQSALPEQK 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   206 AETIVrATPYMKIILNGCVCAIC----ACSFAQSFVLVALVTYLPKYnQIAFKMNLTHNGIWSSLPFFIQMITKLLFAII 281
Cdd:TIGR00895 231 STQGT-KRSVFKALFQGKTARITvllwLLYFMLLVGVYFLTNWLPKL-MVELGFSLSLAATGGALFNFGGVIGSIIFGWL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   282 ADKVKQRKVnatavtkvsnAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSY 361
Cdd:TIGR00895 309 ADRLGPRVT----------ALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGW 378

                         330
                  ....*....|....*..
gi 25141341   362 AQLYAQIASTLAPIVIG 378
Cdd:TIGR00895 379 AIGIGRLGAIIGPILAG 395
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 57-378 1.84e-08

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 56.49  E-value: 1.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLnifGSLLTPFSAiYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17327  67 RFPPSKWLSVFIVL---WGLLTLLTA-AVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 137 IAVSMFLTA---KLCQLHFFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRNRA--ETIVR 211
Cdd:cd17327 143 SIFGGLLAYgvfKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGkgDQKFK 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 212 ATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPkynqiAFKMNLTHNGIWSSL----PFFIQMITKLLFAIIADKVKQ 287
Cdd:cd17327 223 WKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLP-----LILKSLGFYSLQTNLlsvpIGALGAVSLLIAALLSDRFKK 297

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 288 RKVNATAVTkvsnaiaSFASAIFIVIAAygpfdsaelVQLSIIVSMAAFSAYVPGYNTSIVTVapqftAFISSYAQLYAQ 367
Cdd:cd17327 298 RGLFAIFAC-------VLALVGSIILLA---------APNPPGAYFAAYILGGGSYAGFPILL-----SWISSNCAGYTK 356

                       330
                ....*....|.
gi 25141341 368 IASTLAPIVIG 378
Cdd:cd17327 357 RATVLAIMLIF 367
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 21-407 2.84e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 55.77  E-value: 2.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  21 TLQSIRFQTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGF 100
Cdd:cd17371  28 EFGLDEAEAGLLGTVTLAGGAIGGILGGI----LADRFGRVRVLVITILLFAVFTLLCGFA----QNYWQLLILRALAGL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 101 GYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFE-GWPLVFIVyGLIGAvfLVIWHVRLA 179
Cdd:cd17371 100 GFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiAWRVLFLL-GALPA--LLVLFIRRF 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 180 DKprESKYITATELTYIKGGKQRRNRAetiVRATPYMKIILNGCVCAICAcsfaqSFVLVALVTYLPKYNQIAFKMNLTH 259
Cdd:cd17371 177 VK--EPPQWQAARAARRHFADRPSLRE---LFSPPLLRTTLLASLLATGA-----LGGYYGITTWLPSYLTGERGLSFEG 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 260 NGIWSSLPFFIQMITKLLFAIIADKVKQRKvnatavtkvSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSM------ 333
Cdd:cd17371 247 SAGYLVVTILGGFLGYLAGGFLADRIGRRN---------NFALFALGSAISILLYFFLPLSPTLILILGFPLGFfasgpf 317

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141341 334 AAFSAYVP-GYNTSIVTVApQFTAFIssyaqlYAQIASTLAPIVIGRITSHGTIyEWKCAFYSLAGVLAVTGLIF 407
Cdd:cd17371 318 SGMGAYLTeLFPTAVRATA-QGFCYN------VGRIIGALFPFLVGFLATSGSL-GTAIAVFAAVYYIAGLVLAL 384
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 28-384 1.02e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.09  E-value: 1.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMAMvdivRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIP 107
Cdd:cd17324  35 QAGLLVSAYALGYALGALLLGPLS----DRIERRRLLLVLLLLFILGNLLAALA----PSFALLLLARALAGLAHGGFWA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQlhfFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKY 187
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ---LLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 188 ITATELTYIKGGKQRRNRAetivratpymkiilngcVCAICACSFaqsFVLVALVTYLPkynqiAFKMNLTHN-GIWSSL 266
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRL-----------------AYLITFLLF---GGFFALYTYLA-----PFLTDVPGFsSSAIIG 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 267 PFFIQMITKLLFAIIADKVKQRKVNATAVtkvsnAIASFASAIFIVIAAYGPfdSAELVQLSIIVSMAAFSAYVPGYNTS 346
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALL-----IALLLLAAALLLLTLLGP--SPLLLLVGLVLWGLGFFAAHSALQTR 311

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 25141341 347 IVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHG 384
Cdd:cd17324 312 VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG 349
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 57-172 1.41e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 53.33  E-value: 1.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLNIFGSLLTPFSAIYLrsyFPVAAiRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17321  57 RFGRKRVFLIGLALFGLASLLCALAPSLA---FLIAA-RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIG 132

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25141341 137 IAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLV 172
Cdd:cd17321 133 AALGPLLGGLLLELF---GWRWIFLINVPIGLVALL 165
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 27-173 1.66e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.89  E-value: 1.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGmAMVDivrRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVI 106
Cdd:COG0477  49 AQLGWIVSAYLLGRAIGLLLFG-RLGD---RYGRKRVLLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLM 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25141341 107 PAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFFeGWPLVFIVYGLIGAVFLVI 173
Cdd:COG0477 121 PGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL--VAAL-GWRWIFLINAPLGLLALVL 184
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 57-173 4.87e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.82  E-value: 4.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17365  60 RFGRKRVLLVSVALFGLFTLLTAFA----QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLG 135

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25141341 137 IAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVI 173
Cdd:cd17365 136 AALGGFLAAALIPAF---GWRSVFLLGGVPPLILLPL 169
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 28-174 4.97e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.81  E-value: 4.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIP 107
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGR----LKRRLGKRRLLAIGFALMALGFLLLALAS----GLWVVLLGAILAGLGFGLLLP 305

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIW 174
Cdd:cd17473 306 TLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVL 370
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 54-407 5.73e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 5.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIF---- 129
Cdd:cd17489  54 LLDRFGRKRLLLIGLLIFALATLLYLLAT----SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYglat 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 130 TTGNQIGIAVSMFLTAKLcqlhffeGWPLVFIVYGLIGAV-FLVIWHVrladKPRESKYITATELTyikggkqrrnraet 208
Cdd:cd17489 130 TLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALLaLLLVFLV----KDPPPVAAEEAEAG-------------- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 209 ivraTPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYnqiAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQR 288
Cdd:cd17489 185 ----TRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY---AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPK 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 289 KVnatavtkvsnaIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP--QFTAFISSYAQLYA 366
Cdd:cd17489 258 TV-----------IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPphRRGAANGTFFIFFD 326

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 25141341 367 qIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIF 407
Cdd:cd17489 327 -LGIGLGGLLLGLVAEL---FGYRAMFLLAAVVVLLALVLY 363
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 27-336 5.73e-07

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 51.48  E-value: 5.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGMAmvdiVRRLGPKNLLSFALLLNIFGSLltpFSAIYLRSYFPVAAIRLIMGFGYG-FV 105
Cdd:cd17341  34 SQIGLLVAIPVLAGALLRLPYGFL----CDRFGGRRVFIASLLLLLIPLL---ALALAVSSYWGLLVLGFLLGFAGAnFA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 106 IpaGSVLISSWFPLSEKSTA-MAIFTTGNqIGIAVSMFLTAKLCQLHFFE----GWPLVFIVYGLIGAVFLVIwHVRLAD 180
Cdd:cd17341 107 S--GQPWASFWFPKEKIGGAaGGIAGAGN-MGVAVSQLLAPLIAGAIVFDggfvGWRNAFFVPGILLAIAAVL-VLLFGD 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 181 KPRESKYITATELTYIKGGKQRRNraeTIVRATPYmkiilngcvcaicACSFAqsfVLVALVTYLPKYNQIAFKMNLTHN 260
Cdd:cd17341 183 DLPTGKASALEFLKVQLAVLKNYR---TWILSLLY-------------GVTFG---SFVGFSNVLPTYFKTRFGLPLVTA 243

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25141341 261 GIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAF 336
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGGRRR---------LWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALG 310
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-178 6.26e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 6.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  27 FQTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVI 106
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGK----LSDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVF 306

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25141341 107 PAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRL 178
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF---GFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-140 1.18e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.36  E-value: 1.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  22 LQSIRFQTALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFG 101
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFG 309

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25141341 102 YGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVS 140
Cdd:COG2814 310 FGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 19-406 2.18e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.92  E-value: 2.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  19 LWTLQSIRFQTALLISAACVVFGLMRTCFGMAMVDIV-----RRLGPKNLLSFALLLNIFGSLLTPFsaiyLRSYFPVAA 93
Cdd:cd17329  18 VWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIggrlaDRFGRKPVMLAGLLLRALGFALLGF----AHSPWLFAI 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  94 IRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFegwpLVFIVyGLIGAVFLVI 173
Cdd:cd17329  94 ALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR----LLFLA-AAVLFLLAAL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 174 WHVRLadKPRESKYITATELTYIKGGKQrrnraeTIVRATPYMkiilngcvcAICACSFAQSFVLVALVTYLPKYNQiaf 253
Cdd:cd17329 169 VLLFL--LPETRPKRRAAEKTEILRGYK------IVLRDRAFL---------LFLLASFLISLIYFQLESTLPVYVV--- 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 254 kmNLTHNGIWS-SLPFFIQMITKLLFAIIADKVKQRKvnatavtkvsNAIASFASAIFIVIAAYGPFDSAELVqLSIIVS 332
Cdd:cd17329 229 --EILGLGESLlGLLLALNALLIVLLQFPVARLVERF----------RLRKILMIGILLFAIGFAVLAFANTL-AVLILA 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 333 MAAFSA----YVPGYNTSIVTVAPQFT--AFISSYAQLYAqIASTLAPIVIGRITSHGtiyewkcAFYSLAGVLAVTGLI 406
Cdd:cd17329 296 MIVLTLgemlVFPAVQTLVAALAPPDKrgSYMGFYALAWG-LGRAIGPLVGGLLLDLL-------GPGLPWLILAALGLI 367
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-140 3.28e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.09  E-value: 3.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  16 IPPLWtLQSIRFQTALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFsAIYLRSYFPVAAIR 95
Cdd:cd17321 190 LLPLY-LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL-LGADSSVWLLLPGL 267

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25141341  96 LIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVS 140
Cdd:cd17321 268 VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 57-406 8.17e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 47.98  E-value: 8.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17316  62 RIGRKKALILTLLLFGLATLLIGLLP----TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALG 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 137 IAVSMFLTAKLCQLHFFE-GWPLVFIVyGLIGAVFLVIWHVRLadkpreskyitateltyikggkqrrnraetivratpy 215
Cdd:cd17316 138 ALLAALVASLLIPLLSGDwGWRILFLI-GALPALLALLLRRRT------------------------------------- 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 216 mkiilngcVCAICAcSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAv 295
Cdd:cd17316 180 --------LLLILL-WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG- 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 296 tkvsnAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAqIASTLAPI 375
Cdd:cd17316 250 -----LILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRL-GGGGAPPL 323

                       330       340       350
                ....*....|....*....|....*....|.
gi 25141341 376 VIGRITSHGTIYewkcAFYSLAGVLAVTGLI 406
Cdd:cd17316 324 IALLLASTGGTG----VPALILALLAIVALI 350
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 57-407 1.58e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 47.23  E-value: 1.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17328  60 RYNRKWILAVGILIWSAATLLSSFA----PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLG 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 137 IAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESkyitateltyIKGGKQRRNRAETIVRAtpyM 216
Cdd:cd17328 136 SGLGYVVGGLVAQATG--GWRWAFRVTGVLGVLLAILLLLFVREPPRGA----------AEGGVMAKSTATSFLAD---L 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 217 KIIL-NGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITK----LLFAIIADKVKQRKVN 291
Cdd:cd17328 201 KALAkNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGvlgvLLGGILADRLRRKTPR 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 292 ATAVTkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVpGYNTSIV--TVAPQFTAFISSYAQLYAQ-I 368
Cdd:cd17328 281 ADPLV---CAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNW-APVFAILlyVVIPTRRSTASAIQILLSHlL 356

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 25141341 369 ASTLAPIVIGRITSHGTIYE---------WKCAFYSLAGVLAVTGLIF 407
Cdd:cd17328 357 GDAGSPYLIGLISDLLRQNKdsplaeaasLQYALLLCSFVLVLGGFFF 404
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 28-407 1.95e-05

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 46.85  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIP 107
Cdd:cd17345  39 EIGLIGSALSIAYGLSKFVMGN----LSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQGMGWP 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRE--- 184
Cdd:cd17345 115 PSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESegl 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 185 ---SKYITATELTYIKGGKQRRNRAETIVratpyMKIILNGCVcaICACSFAQSFVLVA---LVTYLPKYNQIAFKMNLT 258
Cdd:cd17345 195 ppiEEYKGDYPEEADGEEEEQELSAWEIF-----VKYVLKNKL--LWYIAIANVFVYLVrygILDWAPTYLSEVKGFSKA 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 259 HnGIWSSLPFFIQMI-TKLLFAIIADKvkqrkvnataVTKVSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFS 337
Cdd:cd17345 268 Q-AMWAFSLFEWAAIpGTLLAGWLSDK----------LFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFL 336

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25141341 338 AYVPGYNTSIVT--VAPQFTA-----FISSYAQLyaqIASTLAPIVIGRITSHgtiYEWKCAFYSL--AGVLAVTGLIF 407
Cdd:cd17345 337 IYGPVMLIGLQAleLVPKKAAgtaagLTGLFGYL---GGSVLATALIGIIVDH---FGWNGGFIVLlaSCILAIIFLAL 409
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 55-173 3.18e-05

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 46.14  E-value: 3.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  55 VRRLGPKNLLSFALLLNIFGSLLTPFsaiyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQ 134
Cdd:cd06180  58 RRRGRARRLIRGGLLLTVLLLAAMAL----TSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVG 133

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25141341 135 IGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVI 173
Cdd:cd06180 134 LGIALSGLLVPAGLGGGL--SWRAGWLALALLSAVLLLL 170
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 26-407 3.19e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.11  E-value: 3.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  26 RFQTALLISAACVVFGLMRTCFGMAMvdivRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpvAAIRLIMGFGYG-F 104
Cdd:cd17355  37 RAVISLAFTVGLLAFGLAQPFVGRLL----DRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY---LLWGLLGGGGAGtL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 105 VIPAGSVLISSWFPlSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFFeGWPLVFIVYGLIGAVFLVIWHVRLADKPRE 184
Cdd:cd17355 110 AAVAFATVAAWWFE-RRRGLALGILTAGGGLGSLVFLPLGAAL--IEAF-GWRTALLVLALLALLVLVPVLLLLRRRPAD 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 185 SKYITATELTYIKGGKQRRNraetIVRATPYMKIILNGCVCAicacsFAQSFVLVALVTYLpkynqIAFKMNLTHNGIWS 264
Cdd:cd17355 186 LALRAYDDASPASPGSTLKE----ALRSASFWLLALAFFLCG-----FAVVGLIVHLVPYL-----ADRGISPAAAAVAL 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 265 SLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFsAYVPGYN 344
Cdd:cd17355 252 ALIGLFNIVGRLLSGWLGDRYSPRRL---------LAASYALRALGLALLLLLPFPPLALLLFAALFGLGWG-ATVPLTA 321

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25141341 345 TSIVTVAPQ-FTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLIF 407
Cdd:cd17355 322 ALAARYFGArSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTA--AWALAVALGLIAALLV 383
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 16-413 4.63e-05

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 45.65  E-value: 4.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  16 IPPLwtLQSIRFQTALLISAACVVFGLMRTCFG---MAMVDIVRRLGPKNLLSFALLLNIFGslltpfsaIYLRSYFPVA 92
Cdd:cd17339  18 VGPL--LPEIRDDLGLSASQAGLLTTLPLLCFAvfsPLAPRLARRFGLERTLLLALLLLAAG--------ILLRSLGGIA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  93 AI---RLIMGFGYGFvipaGSVLISSW----FPLSEKStAMAIFTTGNQIGIAVSMFLTAKLCQlHFFEGWPLVFIVYGL 165
Cdd:cd17339  88 LLflgTALAGAGIAV----GNVLLPSLikrdFPRRVGL-MTGLYTTSMNLGAALASGLSVPLAQ-ALGGGWRGALAIWAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 166 IGAVFLVIWHVRLADKPRESKyiTATELTYIKGGKQRRNRAETIvratpYMKIilngcvcaicacsfaQSFVLVALVTYL 245
Cdd:cd17339 162 PALLALLIWLPQLRRRKRAAA--AAAPLTKISVWRSPLAWQVTL-----FMGL---------------QSLLFYTLMAWL 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 246 PKYnQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVTKVSnaIASFAsAIFIVIAAYGPFdsaeLV 325
Cdd:cd17339 220 PTI-LIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLF--IIGVL-GLLFAPTALALL----WA 291

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 326 QLSIIVSMAAFSAYVpgYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRItsHGTIYEWKCAFYslagVLAVTGL 405
Cdd:cd17339 292 VLLGLGGGAAFSLAL--TLISLRSSDPAEAAALSGMAQSVGYLLAALGPLLFGVL--HDLTGSWTAPLV----LLLALTV 363


                ....*...
gi 25141341 406 IFQIFGHG 413
Cdd:cd17339 364 LQLVAGLG 371
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 38-177 7.78e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 7.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  38 VVFGLMRTCFGMAMV-------DIVRRLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGS 110
Cdd:cd06173 244 AGYGLLLAAFGVGALlgalllgRLSKRRRRGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLLGLAGGLFNVPLN 319

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25141341 111 VLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVR 177
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL---GLSAVFLLAGALLLLAALLLLLL 383
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
28-179 8.37e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 8.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  28 QTALLISAACVVFGLMRTCFGMamvdIVRRLGPKNLLSFALLLniFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIP 107
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGW----LSDRLGRRRKLVLAIGL--LLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAVFLVIWHVRLA 179
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 54-173 1.06e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 44.49  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSL-LTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPlSEKSTAMAIFTTG 132
Cdd:cd17320 260 LVRRFGPRRLLRLGLLLLLAAALvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFL 338

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25141341 133 NQIGIAVSMFLTAklcQLHFFEGWP--LVFIVYGLIGAVFLVI 173
Cdd:cd17320 339 QFLIGALAGALVG---LLPNGTALPmgLLILVLGLLALLLLIL 378
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 57-183 1.61e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 43.80  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  57 RLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIG 136
Cdd:cd17312  64 RSNIRRFMSAGLLLSALANIFMGFST----SLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFG 139

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 25141341 137 IAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLADKPR 183
Cdd:cd17312 140 GILAPILAASLASYY---GWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
29-185 2.29e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  29 TALLISAACVVFG-LMRTCFGMamvdIVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAairLIMGFGYGFVIP 107
Cdd:COG2223 242 TAGLLAALFALLGaLGRPLGGW----LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLF---LLLGLALGGGNG 314

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25141341 108 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLhfFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRES 185
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA--TGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 54-178 3.04e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 3.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLtpfsaIYLRSYFPVAAI-RLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTG 132
Cdd:cd17503  54 LADRFGTRRLFLTALALFTLGSLL-----CGLAPNLASLIIfRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 25141341 133 NQIGIAVSMFLTAKLCQlHFfeGWPLVFIV---YGLIGAVFLVIWHVRL 178
Cdd:cd17503 129 ILLAPAIGPTLGGWLTD-NL--SWRWIFYInlpIGILALLLAPLLDLRL 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 18-175 4.05e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.58  E-value: 4.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  18 PLWTLQSIRFQTALLISAACVVFGLMRTCFGmamvDIVRRLGPKNLLSFALLLNIFGSLLtpFSAIYLRSYFPVAAIrlI 97
Cdd:cd17489 218 PLYAAERGISNAGLFFTVYAIALLLSRPFSG----KLSDRKGPKTVIIPGLLLLALGLLL--LSFAGSPWMLLLAAV--L 289

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25141341  98 MGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWH 175
Cdd:cd17489 290 YGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF---GYRAMFLLAAVVVLLALVLYI 364
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 22-141 5.94e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 42.25  E-value: 5.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  22 LQSIRFQTALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLL---TPFSAIYLRSYFPVAairLIM 98
Cdd:cd17476 203 FQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGPILfatMPVHQTYWAQAFPAM---IVA 279

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25141341  99 GFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSM 141
Cdd:cd17476 280 PFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGL 322
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 29-143 9.50e-04

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 41.62  E-value: 9.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  29 TALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPA 108
Cdd:cd17334  37 SASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPLGQQPKFALLVLGQVLNALAQVLVLSL 116

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25141341 109 GSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFL 143
Cdd:cd17334 117 PPLIAAVWFPPKERTTATAIASLANFLGCAIGFLL 151
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 54-143 1.63e-03

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 40.69  E-value: 1.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAiRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd17398  62 LLEKYGLRVTVLLGSFLNCLGAWLKLFSSSPDLFWVAMAG-QTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGN 140

                        90
                ....*....|
gi 25141341 134 QIGIAVSMFL 143
Cdd:cd17398 141 QLGVALGFVL 150
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 54-174 2.65e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 40.32  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAIyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTamaiFTTGN 133
Cdd:cd17357  72 LANRFGRKNGLLISNALLVVSSLLMFLSKS-AKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGA----LGSLT 146

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25141341 134 QIGIAVsMFLTAKLCQLHFFEG----WPLVFIVYGLIGAVFLVIW 174
Cdd:cd17357 147 QIGVTL-GILLGQVFGLPSVLGtetlWPYLLFFPGIPALLQLAAL 190
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 22-173 3.32e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.86  E-value: 3.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  22 LQSIRFQTALLISAACVvfGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFG 101
Cdd:cd17315 207 FKSAGGGTASILASIIV--GVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILL 284

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25141341 102 Y--GFVIPAGSV---LISSWFPLSEKSTAMAIFTTGNQI--GIAVSMFLTAKLCQlhffeGWPLVFIVYGLIGAVFLVI 173
Cdd:cd17315 285 YiaAFAMGAGPVpwlLLSEIFPLRIRGKGMAIATLVNWIfnFIVGLTFLIMVSTI-----GLAGVFIFFAAVCLLALVF 358
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
91-341 3.69e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 3.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  91 VAAIRLIMGFGYGFVIPAGSVLISSWFP-LSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFF-----EGWPLVFIVYG 164
Cdd:COG2211 113 ALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPL--VAAFggdaaLGYRLTALIFA 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 165 LIGAVFLVIWHVRLadkpRESKYITATELTYIKGGKQ-RRNRaetivratPYMKiilngcvcaICACSFAQSFVLVALVT 243
Cdd:COG2211 191 VLGLLAFLLTFFGT----KERPVPEEEKVSLKESLKAlLKNR--------PFLL---------LLLAYLLFFLALALVAA 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 244 YLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDSAE 323
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKA---------FIIGLLLAALGLLLLFFLGPGNLW 320

                       250
                ....*....|....*...
gi 25141341 324 LVQLSIIVSMAAFSAYVP 341
Cdd:COG2211 321 LLLVLAALAGIGLGAILV 338
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 18-139 3.71e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.48  E-value: 3.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  18 PLWtLQSIRFQTALLISAACVVFGLMrTCFGMAMVD-IVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLrSYFPVAAIRL 96
Cdd:cd17503 202 PLY-LQNVLGYSAFESGLVLAPGGLA-SAILSPLVGrLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDT-SLWLIILPLF 278

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25141341  97 IMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAV 139
Cdd:cd17503 279 IRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSI 321
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 54-173 3.86e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 3.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341  54 IVRRLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIrlIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGN 133
Cdd:cd17330 234 LAKRLGERKLLRLGLLLAIIGLLLLPFASSV--PLLVLAAA--ILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ 309

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 25141341 134 QIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAVFLVI 173
Cdd:cd17330 310 SLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
226-407 4.35e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 4.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 226 AICACSFAQSFVLVALVTYLPKYnQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVtkvsnAIASF 305
Cdd:COG0738  12 AIYLLFFLWGFATALWGPLIPAL-KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL-----LLMAL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341 306 ASAIFIVIAAYGPFdsaelvQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHGT 385
Cdd:COG0738  86 GLLLFALAPSYPLL------LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGL 159

                       170       180
                ....*....|....*....|..
gi 25141341 386 IYEWKCAFYSLAGVLAVTGLIF 407
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLF 181
MFS_1 pfam07690
Major Facilitator Superfamily;
227-407 5.45e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   227 ICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnAIASFA 306
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV----------LLIGLL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141341   307 SAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHgti 386
Cdd:pfam07690  71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--- 147

                         170       180
                  ....*....|....*....|.
gi 25141341   387 YEWKCAFYSLAGVLAVTGLIF 407
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLL 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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