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Conserved domains on  [gi|25145466|ref|NP_740945|]
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SANT_DAMP1_like domain-containing protein [Caenorhabditis elegans]

Protein Classification

DNA methyltransferase 1-associated protein 1( domain architecture ID 11242173)

DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in transcription repression and activation

CATH:  1.20.58.1880
Gene Symbol:  DMAP1
Gene Ontology:  GO:0003714|GO:0003677|GO:0006281|GO:0006355|GO:0003700
PubMed:  19845771|8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMAP1 pfam05499
DNA methyltransferase 1-associated protein 1 (DMAP1); DNA methylation can contribute to ...
 223-390 4.31e-68

DNA methyltransferase 1-associated protein 1 (DMAP1); DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication.


:

Pssm-ID: 398903  Cd Length: 163  Bit Score: 215.23  E-value: 4.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   223 EEEDLTAELRRIELRKKEREKKAHDLQKLINMSEQQPASPSAGGIGGAasaKRKNAFRTKAGSISTTATTffnpldisVT 302
Cdd:pfam05499   1 EEEMLLQELRKIEARKKEREKKTQDLQKLITAADSQAEARRSERKSTK---KKLPQQRSKESSVSPEPVL--------TA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   303 ALRFSEFKSSGAHFRCQEMKLPTNIGQKKLKNIEVVLEKCKMEMNPVASEPIMKTYNDFRSQIMLAQELKSAMQTAEFEL 382
Cdd:pfam05499  70 GIKFPDFKSSGVSLRSQRMKLPASVGQKKTKAIEQLLEELKIDLNPMPTEEICQHFNELRSDIVLLYELKQALANCEFEL 149


                  ....*...
gi 25145466   383 ESIRTRMQ 390
Cdd:pfam05499 150 QSLRHQYE 157
SANT_DAMP1_like pfam16282
SANT/Myb-like domain of DAMP1; This domain, approximately 90 residues, is mainly found in DNA ...
 106-185 2.34e-41

SANT/Myb-like domain of DAMP1; This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site.


:

Pssm-ID: 465084  Cd Length: 80  Bit Score: 142.22  E-value: 2.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   106 YPFSRFNKVIDIPIYTDDEYENYLKIAKWSREETDYLFDTCRMFDLRWPIVYDRFDCKKFnQNRTVEDLKERFYSITYEL 185
Cdd:pfam16282   1 YPFAKFNKKVDIPTYTDEEYERHLKDDDWTKEETDYLFDLCRRYDLRFIVIADRYDFPPG-KKRSVEDLKERYYSVCRKL 79
 
Name Accession Description Interval E-value
DMAP1 pfam05499
DNA methyltransferase 1-associated protein 1 (DMAP1); DNA methylation can contribute to ...
 223-390 4.31e-68

DNA methyltransferase 1-associated protein 1 (DMAP1); DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication.


Pssm-ID: 398903  Cd Length: 163  Bit Score: 215.23  E-value: 4.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   223 EEEDLTAELRRIELRKKEREKKAHDLQKLINMSEQQPASPSAGGIGGAasaKRKNAFRTKAGSISTTATTffnpldisVT 302
Cdd:pfam05499   1 EEEMLLQELRKIEARKKEREKKTQDLQKLITAADSQAEARRSERKSTK---KKLPQQRSKESSVSPEPVL--------TA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   303 ALRFSEFKSSGAHFRCQEMKLPTNIGQKKLKNIEVVLEKCKMEMNPVASEPIMKTYNDFRSQIMLAQELKSAMQTAEFEL 382
Cdd:pfam05499  70 GIKFPDFKSSGVSLRSQRMKLPASVGQKKTKAIEQLLEELKIDLNPMPTEEICQHFNELRSDIVLLYELKQALANCEFEL 149


                  ....*...
gi 25145466   383 ESIRTRMQ 390
Cdd:pfam05499 150 QSLRHQYE 157
SANT_DAMP1_like pfam16282
SANT/Myb-like domain of DAMP1; This domain, approximately 90 residues, is mainly found in DNA ...
 106-185 2.34e-41

SANT/Myb-like domain of DAMP1; This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site.


Pssm-ID: 465084  Cd Length: 80  Bit Score: 142.22  E-value: 2.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   106 YPFSRFNKVIDIPIYTDDEYENYLKIAKWSREETDYLFDTCRMFDLRWPIVYDRFDCKKFnQNRTVEDLKERFYSITYEL 185
Cdd:pfam16282   1 YPFAKFNKKVDIPTYTDEEYERHLKDDDWTKEETDYLFDLCRRYDLRFIVIADRYDFPPG-KKRSVEDLKERYYSVCRKL 79
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 134-181 3.25e-15

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 69.36  E-value: 3.25e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 25145466 134 WSREETDYLFDTCRMFDLRWPIVYDRFDckkFNQNRTVEDLKERFYSI 181
Cdd:cd11658   1 WTKEETDYLFDLVKRFDLRWNVILDRYP---FQKGRSVEDLKEKYYHL 45
 
Name Accession Description Interval E-value
DMAP1 pfam05499
DNA methyltransferase 1-associated protein 1 (DMAP1); DNA methylation can contribute to ...
 223-390 4.31e-68

DNA methyltransferase 1-associated protein 1 (DMAP1); DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication.


Pssm-ID: 398903  Cd Length: 163  Bit Score: 215.23  E-value: 4.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   223 EEEDLTAELRRIELRKKEREKKAHDLQKLINMSEQQPASPSAGGIGGAasaKRKNAFRTKAGSISTTATTffnpldisVT 302
Cdd:pfam05499   1 EEEMLLQELRKIEARKKEREKKTQDLQKLITAADSQAEARRSERKSTK---KKLPQQRSKESSVSPEPVL--------TA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   303 ALRFSEFKSSGAHFRCQEMKLPTNIGQKKLKNIEVVLEKCKMEMNPVASEPIMKTYNDFRSQIMLAQELKSAMQTAEFEL 382
Cdd:pfam05499  70 GIKFPDFKSSGVSLRSQRMKLPASVGQKKTKAIEQLLEELKIDLNPMPTEEICQHFNELRSDIVLLYELKQALANCEFEL 149


                  ....*...
gi 25145466   383 ESIRTRMQ 390
Cdd:pfam05499 150 QSLRHQYE 157
SANT_DAMP1_like pfam16282
SANT/Myb-like domain of DAMP1; This domain, approximately 90 residues, is mainly found in DNA ...
 106-185 2.34e-41

SANT/Myb-like domain of DAMP1; This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site.


Pssm-ID: 465084  Cd Length: 80  Bit Score: 142.22  E-value: 2.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145466   106 YPFSRFNKVIDIPIYTDDEYENYLKIAKWSREETDYLFDTCRMFDLRWPIVYDRFDCKKFnQNRTVEDLKERFYSITYEL 185
Cdd:pfam16282   1 YPFAKFNKKVDIPTYTDEEYERHLKDDDWTKEETDYLFDLCRRYDLRFIVIADRYDFPPG-KKRSVEDLKERYYSVCRKL 79
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 134-181 3.25e-15

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 69.36  E-value: 3.25e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 25145466 134 WSREETDYLFDTCRMFDLRWPIVYDRFDckkFNQNRTVEDLKERFYSI 181
Cdd:cd11658   1 WTKEETDYLFDLVKRFDLRWNVILDRYP---FQKGRSVEDLKEKYYHL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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