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Conserved domains on  [gi|25147884|ref|NP_740981|]
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BTB domain-containing protein [Caenorhabditis elegans]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13034536)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Drosophila melanogaster mrityu, isoform E

Gene Ontology:  GO:0005515
PubMed:  27521773|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KCTD20-like cd18318
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 232-328 5.82e-54

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10); KCTD20, also termed potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. BTBD10, also termed glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.


:

Pssm-ID: 349627  Cd Length: 92  Bit Score: 178.28  E-value: 5.82e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 232 DKVCLLVDQTRFLVSQRLLTSKPDTMLGRMFSMRascgdLGADLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCPS 311
Cdd:cd18318   1 EKVTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSG-----LENNFTRPNERGEYEVADGISATVFRAILDYYKTGIIRCPP 75

                        90
                ....*....|....*..
gi 25147884 312 SVSVSELREACDYLLVP 328
Cdd:cd18318  76 SVSVAELREACDYLLIP 92
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 79-181 3.93e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884    79 TSSTRTVRAPQQVSWSFGAKPATPHSQP--------------PAGLKKVPAYSATSSSsqagPSASTSTARKSSLV---- 140
Cdd:pfam05109 467 TVSTADVTSPTPAGTTSGASPVTPSPSPrdngteskapdmtsPTSAVTTPTPNATSPT----PAVTTPTPNATSPTlgkt 542

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 25147884   141 --GGRGSASSSGHTSPSPS-ESPARNAGCSSSGESNPDRSLTTP 181
Cdd:pfam05109 543 spTSAVTTPTPNATSPTPAvTTPTPNATIPTLGKTSPTSAVTTP 586
 
Name Accession Description Interval E-value
BTB_POZ_KCTD20-like cd18318
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 232-328 5.82e-54

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10); KCTD20, also termed potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. BTBD10, also termed glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.


Pssm-ID: 349627  Cd Length: 92  Bit Score: 178.28  E-value: 5.82e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 232 DKVCLLVDQTRFLVSQRLLTSKPDTMLGRMFSMRascgdLGADLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCPS 311
Cdd:cd18318   1 EKVTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSG-----LENNFTRPNERGEYEVADGISATVFRAILDYYKTGIIRCPP 75

                        90
                ....*....|....*..
gi 25147884 312 SVSVSELREACDYLLVP 328
Cdd:cd18318  76 SVSVAELREACDYLLIP 92
BTB_3 pfam16017
BTB/POZ domain;
233-343 6.62e-49

BTB/POZ domain;


Pssm-ID: 464976  Cd Length: 106  Bit Score: 165.20  E-value: 6.62e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884   233 KVCLLVDQTRFLVSQRLLTSKPDTMLGRMFSmraSCgdLGADLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCPSS 312
Cdd:pfam16017   1 RLTLVVDGTRFVVDPSLFTAHPDTMLGRMFG---SS--MERNFTRPNEKGEYEIAEGISSTVFRAILDYYKTGVIRCPPS 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 25147884   313 VSVSELREACDYLLVPFNAQTVKCQNLHALL 343
Cdd:pfam16017  76 VSIPELREACDYLLIPFDATTIKCQNLRALL 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 234-340 1.15e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 38.44  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884    234 VCLLVDQTRFLVSQRLLTSKPDTMLGrMFSMRASCGDLgadlvspnerDEFEVaDGMTSSCFRAILDYYQSGTMRCPSSv 313
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKA-LFSSDFKESDK----------SEIYL-DDVSPEDFRALLNFLYTGKLDLPEE- 68

                           90       100
                   ....*....|....*....|....*..
gi 25147884    314 SVSELREACDYLLVPFNAQTVKCQNLH 340
Cdd:smart00225  69 NVEELLELADYLQIPGLVELCEEFLLK 95
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 79-181 3.93e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884    79 TSSTRTVRAPQQVSWSFGAKPATPHSQP--------------PAGLKKVPAYSATSSSsqagPSASTSTARKSSLV---- 140
Cdd:pfam05109 467 TVSTADVTSPTPAGTTSGASPVTPSPSPrdngteskapdmtsPTSAVTTPTPNATSPT----PAVTTPTPNATSPTlgkt 542

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 25147884   141 --GGRGSASSSGHTSPSPS-ESPARNAGCSSSGESNPDRSLTTP 181
Cdd:pfam05109 543 spTSAVTTPTPNATSPTPAvTTPTPNATIPTLGKTSPTSAVTTP 586
 
Name Accession Description Interval E-value
BTB_POZ_KCTD20-like cd18318
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 232-328 5.82e-54

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10); KCTD20, also termed potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. BTBD10, also termed glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.


Pssm-ID: 349627  Cd Length: 92  Bit Score: 178.28  E-value: 5.82e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 232 DKVCLLVDQTRFLVSQRLLTSKPDTMLGRMFSMRascgdLGADLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCPS 311
Cdd:cd18318   1 EKVTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSG-----LENNFTRPNERGEYEVADGISATVFRAILDYYKTGIIRCPP 75

                        90
                ....*....|....*..
gi 25147884 312 SVSVSELREACDYLLVP 328
Cdd:cd18318  76 SVSVAELREACDYLLIP 92
BTB_3 pfam16017
BTB/POZ domain;
233-343 6.62e-49

BTB/POZ domain;


Pssm-ID: 464976  Cd Length: 106  Bit Score: 165.20  E-value: 6.62e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884   233 KVCLLVDQTRFLVSQRLLTSKPDTMLGRMFSmraSCgdLGADLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCPSS 312
Cdd:pfam16017   1 RLTLVVDGTRFVVDPSLFTAHPDTMLGRMFG---SS--MERNFTRPNEKGEYEIAEGISSTVFRAILDYYKTGVIRCPPS 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 25147884   313 VSVSELREACDYLLVPFNAQTVKCQNLHALL 343
Cdd:pfam16017  76 VSIPELREACDYLLIPFDATTIKCQNLRALL 106
BTB_POZ_BTBD10_GMRP1 cd18385
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 232-344 1.80e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349693  Cd Length: 110  Bit Score: 129.03  E-value: 1.80e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 232 DKVCLLVDQTRFLVSQRLLTSKPDTMLGRMF-SMRAScgdlgaDLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCP 310
Cdd:cd18385   3 ERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFgSGREH------NFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCP 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 25147884 311 SSVSVSELREACDYLLVPFNAQTVKCQNLHALLH 344
Cdd:cd18385  77 DGISIPELREACDYLCISFDYSTIKCRDLSALMH 110
BTB_POZ_KCTD20 cd18386
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 232-338 6.20e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20); KCTD20, also called potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349694  Cd Length: 104  Bit Score: 121.61  E-value: 6.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 232 DKVCLLVDQTRFLVSQRLLTSKPDTMLGRMFSMRAScgdlgADLVSPNERDEFEVADGMTSSCFRAILDYYQSGTMRCPS 311
Cdd:cd18386   3 EKVTLIVDGTRFVVNPQIFTAHPDTMLGRMFGPGRE-----YNFTRPNEKGEYEIAEGISCTVFRTVLDYYKTGIINCPD 77

                        90       100
                ....*....|....*....|....*..
gi 25147884 312 SVSVSELREACDYLLVPFNAQTVKCQN 338
Cdd:cd18386  78 GISIPDLRDTCDYLCINFDFNTIKCQD 104
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 234-325 4.48e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 73.28  E-value: 4.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 234 VCLLVDQTRFLVSQRLLTSKPDTMLGRMFSMrascgdlGADLVSPNERDEFEVADGMTSscFRAILDYYQSGTMRCPSSV 313
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKP-------GREFTFPNETGEYFIDRDPTV--FRTILNYYRTGKLNCPDGI 71

                        90
                ....*....|..
gi 25147884 314 SVSELREACDYL 325
Cdd:cd18187  72 SIPDLREECDFY 83
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 241-324 4.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 50.30  E-value: 4.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 241 TRFLVSQRLLTSKPDTMLGRMfsmrasCGDLGADLVSPNE----RDefevadgmtSSCFRAILDYYQSGTMRCPSSVSVS 316
Cdd:cd18317   8 TRFELSRSTLLRFPDTRLGKL------AKESHAYDESTNEyffdRN---------PEVFEAILDYYRTGELHLPSNVCPA 72


                ....*...
gi 25147884 317 ELREACDY 324
Cdd:cd18317  73 SFKEELEF 80
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 241-324 4.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 44.86  E-value: 4.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884 241 TRFLVSQRLLTSKPDTMLGRMFSMRascgdlgadlvSPNERDEFEV----ADGmtsSCFRAILDYYQSGTMRCPSSVSVS 316
Cdd:cd18316   8 TLFTTSRSTLLKDPDSLLAALFSGR-----------WPLPRDEDGSifidRDP---ELFRHILNFLRTGKLPLPSDFVEL 73

                        90
                ....*....|
gi 25147884 317 E--LREACDY 324
Cdd:cd18316  74 EelLAEAEFY 83
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 241-324 7.52e-06

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 44.50  E-value: 7.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884   241 TRFLVSQRLLTSKPDTMLGRMFSMRasCGDLGADLvspNE----RDefevadgmtSSCFRAILDYYQS-GTMRCPSSVSV 315
Cdd:pfam02214   8 TRFETLKSTLTRFPDTRLGRLLELE--CDDYDDDT---NEyffdRS---------PKHFETILNFYRTgGKLHRPEEVCL 73


                  ....*....
gi 25147884   316 SELREACDY 324
Cdd:pfam02214  74 DEFLEEAEF 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 234-340 1.15e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 38.44  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884    234 VCLLVDQTRFLVSQRLLTSKPDTMLGrMFSMRASCGDLgadlvspnerDEFEVaDGMTSSCFRAILDYYQSGTMRCPSSv 313
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKA-LFSSDFKESDK----------SEIYL-DDVSPEDFRALLNFLYTGKLDLPEE- 68

                           90       100
                   ....*....|....*....|....*..
gi 25147884    314 SVSELREACDYLLVPFNAQTVKCQNLH 340
Cdd:smart00225  69 NVEELLELADYLQIPGLVELCEEFLLK 95
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 79-181 3.93e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25147884    79 TSSTRTVRAPQQVSWSFGAKPATPHSQP--------------PAGLKKVPAYSATSSSsqagPSASTSTARKSSLV---- 140
Cdd:pfam05109 467 TVSTADVTSPTPAGTTSGASPVTPSPSPrdngteskapdmtsPTSAVTTPTPNATSPT----PAVTTPTPNATSPTlgkt 542

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 25147884   141 --GGRGSASSSGHTSPSPS-ESPARNAGCSSSGESNPDRSLTTP 181
Cdd:pfam05109 543 spTSAVTTPTPNATSPTPAvTTPTPNATIPTLGKTSPTSAVTTP 586
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 238-305 8.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 36.33  E-value: 8.34e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25147884 238 VDQTRFLVSQRLLTSKPDTMLGRMF-----SMRASCGDlgADLVSpNERdEFEvadgMTSSCFRAILDYYQSG 305
Cdd:cd18424   5 VGGSRFVLSQQVLSSHPETRLGKLAvsvrdSVLELCDD--ANFVD-NEY-FFD----RSSQAFKYIMNYYKTG 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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