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Conserved domains on  [gi|25148657|ref|NP_741136|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 15978888)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
PubMed:  10581972|31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 168-344 2.37e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 168 ERLVEVALLSTSrLELLDLSRTNLTARQMQI---MLKPCQKLKCLSIEGNQLDDHVAICIAE----NRGLRELDISMtNG 240
Cdd:COG5238 198 EELAEALTQNTT-VTTLWLKRNPIGDEGAEIlaeALKGNKSLTTLDLSNNQIGDEGVIALAEalknNTTVETLYLSG-NQ 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 241 ITANGASLI---FRNCKDLQQLNLAWCGLTQPIVTVIIHSIGE--KLKKLNLSGTvrnfGINNKHIEILAA--KSNY-VT 312
Cdd:COG5238 276 IGAEGAIALakaLQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnkTLHTLNLAYN----GIGAQGAIALAKalQENTtLH 351

                       170       180       190
                ....*....|....*....|....*....|....*
gi 25148657 313 DLDLSDNvEISDPG---LAVILNKFPRLTTISLNR 344
Cdd:COG5238 352 SLDLSDN-QIGDEGaiaLAKYLEGNTTLRELNLGK 385
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 89-127 1.33e-07

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.48  E-value: 1.33e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 25148657    89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNW 127
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 168-344 2.37e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 168 ERLVEVALLSTSrLELLDLSRTNLTARQMQI---MLKPCQKLKCLSIEGNQLDDHVAICIAE----NRGLRELDISMtNG 240
Cdd:COG5238 198 EELAEALTQNTT-VTTLWLKRNPIGDEGAEIlaeALKGNKSLTTLDLSNNQIGDEGVIALAEalknNTTVETLYLSG-NQ 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 241 ITANGASLI---FRNCKDLQQLNLAWCGLTQPIVTVIIHSIGE--KLKKLNLSGTvrnfGINNKHIEILAA--KSNY-VT 312
Cdd:COG5238 276 IGAEGAIALakaLQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnkTLHTLNLAYN----GIGAQGAIALAKalQENTtLH 351

                       170       180       190
                ....*....|....*....|....*....|....*
gi 25148657 313 DLDLSDNvEISDPG---LAVILNKFPRLTTISLNR 344
Cdd:COG5238 352 SLDLSDN-QIGDEGaiaLAKYLEGNTTLRELNLGK 385
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 89-127 1.33e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.48  E-value: 1.33e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 25148657    89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNW 127
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
90-128 7.70e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.51  E-value: 7.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 25148657     90 IPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNWI 128
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 89-118 2.77e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.89  E-value: 2.77e-05
                        10        20        30
                ....*....|....*....|....*....|
gi 25148657  89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFY 118
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWR 31
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 147-370 3.67e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 44.63  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 147 QRKIKVLRLAGAKADRILradERLVEVALLSTSRLELLDLSRTNLTARQMQImlkpCQKLKCLSIEGNQL-DDHVAICIA 225
Cdd:cd09293   2 DPLLFILHKLGQITQSNI---SQLLRILHSGLEWLELYMCPISDPPLDQLSN----CNKLKKLILPGSKLiDDEGLIALA 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 226 EN-RGLRELDISMTNGITANGASLIFRNCKdlqqlnlawcgltqpivtviihsigeKLKKLNLSGTVRNFGINNKHIEIL 304
Cdd:cd09293  75 QScPNLQVLDLRACENITDSGIVALATNCP--------------------------KLQTINLGRHRNGHLITDVSLSAL 128

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 305 AAKSNYVTDLDLSdNVEISDPGL-AVILNKFPRLTTISLNRCYGLDP---NMVVHFNSKPSLVYLNVHGC 370
Cdd:cd09293 129 GKNCTFLQTVGFA-GCDVTDKGVwELASGCSKSLERLSLNNCRNLTDqsiPAILASNYFPNLSVLEFRGC 197
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 168-344 2.37e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 168 ERLVEVALLSTSrLELLDLSRTNLTARQMQI---MLKPCQKLKCLSIEGNQLDDHVAICIAE----NRGLRELDISMtNG 240
Cdd:COG5238 198 EELAEALTQNTT-VTTLWLKRNPIGDEGAEIlaeALKGNKSLTTLDLSNNQIGDEGVIALAEalknNTTVETLYLSG-NQ 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 241 ITANGASLI---FRNCKDLQQLNLAWCGLTQPIVTVIIHSIGE--KLKKLNLSGTvrnfGINNKHIEILAA--KSNY-VT 312
Cdd:COG5238 276 IGAEGAIALakaLQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnkTLHTLNLAYN----GIGAQGAIALAKalQENTtLH 351

                       170       180       190
                ....*....|....*....|....*....|....*
gi 25148657 313 DLDLSDNvEISDPG---LAVILNKFPRLTTISLNR 344
Cdd:COG5238 352 SLDLSDN-QIGDEGaiaLAKYLEGNTTLRELNLGK 385
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 89-127 1.33e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.48  E-value: 1.33e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 25148657    89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNW 127
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
90-128 7.70e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.51  E-value: 7.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 25148657     90 IPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNWI 128
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
179-332 6.28e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 6.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 179 SRLELLDLSRTNLTarQMQIMLKPCQKLKCLSIEGNQLDDhVAICIAENRGLRELDISmTNGITANGASLifRNCKDLQQ 258
Cdd:COG4886 159 TNLKSLDLSNNQLT--DLPEELGNLTNLKELDLSNNQITD-LPEPLGNLTNLEELDLS-GNQLTDLPEPL--ANLTNLET 232

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25148657 259 LNLAWCGLTQpivtviIHSIGE--KLKKLNLSG---TVRNFGINNKHIEILAAKSNYVTDLDLSDNVEISDPGLAVILN 332
Cdd:COG4886 233 LDLSNNQLTD------LPELGNltNLEELDLSNnqlTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 89-118 2.77e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.89  E-value: 2.77e-05
                        10        20        30
                ....*....|....*....|....*....|
gi 25148657  89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFY 118
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWR 31
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 147-370 3.67e-05

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 44.63  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 147 QRKIKVLRLAGAKADRILradERLVEVALLSTSRLELLDLSRTNLTARQMQImlkpCQKLKCLSIEGNQL-DDHVAICIA 225
Cdd:cd09293   2 DPLLFILHKLGQITQSNI---SQLLRILHSGLEWLELYMCPISDPPLDQLSN----CNKLKKLILPGSKLiDDEGLIALA 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 226 EN-RGLRELDISMTNGITANGASLIFRNCKdlqqlnlawcgltqpivtviihsigeKLKKLNLSGTVRNFGINNKHIEIL 304
Cdd:cd09293  75 QScPNLQVLDLRACENITDSGIVALATNCP--------------------------KLQTINLGRHRNGHLITDVSLSAL 128

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 305 AAKSNYVTDLDLSdNVEISDPGL-AVILNKFPRLTTISLNRCYGLDP---NMVVHFNSKPSLVYLNVHGC 370
Cdd:cd09293 129 GKNCTFLQTVGFA-GCDVTDKGVwELASGCSKSLERLSLNNCRNLTDqsiPAILASNYFPNLSVLEFRGC 197
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 89-116 4.17e-05

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 40.70  E-value: 4.17e-05
                        10        20
                ....*....|....*....|....*...
gi 25148657  89 SIPDEITEQIFSNLKKKDLLSAMLVCHR 116
Cdd:cd22104   3 NLPSVVLVHIFSYLPPRDRLRASSTCRR 30
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 88-127 5.83e-05

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 40.10  E-value: 5.83e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 25148657  88 YSIPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNW 127
Cdd:cd22091   2 EELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELW 41
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 90-118 1.32e-04

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 1.32e-04
                        10        20
                ....*....|....*....|....*....
gi 25148657  90 IPDEITEQIFSNLKKKDLLSAMLVCHRFY 118
Cdd:cd22132   4 LPDSLLLHIFSYLSPKDLLAAGQVCKQWY 32
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 89-120 1.98e-04

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 38.47  E-value: 1.98e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 25148657  89 SIPDEITEQIFSNLKK-KDLLSAMLVCHRFYGI 120
Cdd:cd22110   3 DLPEEILEYILSYLSPyGDLKSAALVCKRWHRI 35
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-344 2.39e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 2.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 126 NWIITDAQDRPISEISLIALSQRKIKVLRLAGAKADRILRADERLvevALLSTSRLELLDLSRTNLTarQMQIMLKPCQK 205
Cdd:COG4886  63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---ELSNLTNLESLDLSGNQLT--DLPEELANLTN 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 206 LKCLSIEGNQLDDhVAICIAENRGLRELDISMtNGITANGASLifRNCKDLQQLNLAWCGLTQpivtvIIHSIGE--KLK 283
Cdd:COG4886 138 LKELDLSNNQLTD-LPEPLGNLTNLKSLDLSN-NQLTDLPEEL--GNLTNLKELDLSNNQITD-----LPEPLGNltNLE 208

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25148657 284 KLNLSGTvrnfGINNKHIEIlaAKSNYVTDLDLSDNvEISD-PGLAvilnKFPRLTTISLNR 344
Cdd:COG4886 209 ELDLSGN----QLTDLPEPL--ANLTNLETLDLSNN-QLTDlPELG----NLTNLEELDLSN 259
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 88-120 3.80e-04

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 37.99  E-value: 3.80e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 25148657  88 YSIPDEITEQIFSNLKKKDLLSAMLVCHRFYGI 120
Cdd:cd22139   2 LCLPDELWLHIFSFLSPKDLCQVALVCRRFNRL 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
179-319 5.74e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 5.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 179 SRLELLDLSRTNLTarQMQIMLKPCQKLKCLSIEGNQLDDhVAICIAENRGLRELDISmTNGITAngASLIFRNCKDLQQ 258
Cdd:COG4886 136 TNLKELDLSNNQLT--DLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLS-NNQITD--LPEPLGNLTNLEE 209

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25148657 259 LNLAWCGLTQpivtvIIHSIGE--KLKKLNLSGT----VRNFGiNNKHIEILAAKSNYVTDLDLSDN 319
Cdd:COG4886 210 LDLSGNQLTD-----LPEPLANltNLETLDLSNNqltdLPELG-NLTNLEELDLSNNQLTDLPPLAN 270
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 248-387 6.69e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 40.77  E-value: 6.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 248 LIFRNCKDLQQLNLAWCgltqPIVTVIIH--SIGEKLKKLNLSGtvrNFGINNKHIEILAAKSNYVTDLDLSDNVEISDP 325
Cdd:cd09293  22 LLRILHSGLEWLELYMC----PISDPPLDqlSNCNKLKKLILPG---SKLIDDEGLIALAQSCPNLQVLDLRACENITDS 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25148657 326 GLAVILNKFPRLTTISLNR---CYGL-DPNMVVHFNSKPSLVYLNVHGC-VSDTNM-ELFLEMCSNLK 387
Cdd:cd09293  95 GIVALATNCPKLQTINLGRhrnGHLItDVSLSALGKNCTFLQTVGFAGCdVTDKGVwELASGCSKSLE 162
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 89-128 1.10e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 25148657    89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNWI 128
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 174-345 1.11e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 174 ALLSTSRLELLDLSRTNLTARQMQImLKPCQK---LKCLSIEGNQLDDHVAICIAenRGLRELDISMT------NGITAN 244
Cdd:cd00116  76 GLTKGCGLQELDLSDNALGPDGCGV-LESLLRsssLQELKLNNNGLGDRGLRLLA--KGLKDLPPALEklvlgrNRLEGA 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 245 GA---SLIFRNCKDLQQLNLAWCGLTQPIVTVIIHSIGE--KLKKLNLsgtvRNFGINNKHIEILAA--KSN-YVTDLDL 316
Cdd:cd00116 153 SCealAKALRANRDLKELNLANNGIGDAGIRALAEGLKAncNLEVLDL----NNNGLTDEGASALAEtlASLkSLEVLNL 228

                       170       180       190
                ....*....|....*....|....*....|...
gi 25148657 317 SDNVeISDPGLAVILNKFP----RLTTISLNRC 345
Cdd:cd00116 229 GDNN-LTDAGAAALASALLspniSLLTLSLSCN 260
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 89-125 1.18e-03

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 36.29  E-value: 1.18e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 25148657  89 SIPDEITEQIFSNLKK-KDLLSAMLVCHRFYGIGHKSR 125
Cdd:cd22159   3 LLPDEILELIFSYLSDpWDRNSCSLVCKRWYRLERATR 40
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 174-246 3.44e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 3.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148657 174 ALLSTSRLELLDLSRTNLTARQMQIMLKPCQK---LKCLSIEGNQLDDHVAICIAE----NRGLRELDISmTNGITANGA 246
Cdd:COG5238 315 GLQGNKTLHTLNLAYNGIGAQGAIALAKALQEnttLHSLDLSDNQIGDEGAIALAKylegNTTLRELNLG-KNNIGKQGA 393
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 89-120 3.75e-03

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 35.31  E-value: 3.75e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 25148657  89 SIPDEITEQIFSNLKKKDLLSAMLVCHRFYGI 120
Cdd:cd22084   3 DLPSDPLLNILSFLDYRDLISCSQVCRRLNQL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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