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Conserved domains on  [gi|25150738|ref|NP_741269|]
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Coronin-like protein cor-1 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-383 4.92e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 250.58  E-value: 4.92e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738    8 SKFRHVFCKPVKHESCMSDIRVTEITWD-SLFCDVNPKFIAFINRGAGGPfMVIPVNKIGRVDKDYPFVDAHKAPCLEVA 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGST-AVLKHTDYGKLASNPPILLGQEGPIIDVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   87 WSPFNDNVIASCSEDTTCKVWVIPDRGLNRNLSEPAVELTGHQKRVNTIAWHPVANNVLLTAGGENVMFMWNVGTGEALL 166
Cdd:PTZ00421  83 FNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  167 EISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVKPQRAIFVK-DGLILSTGFTKRSERLYALR 245
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKrKDLIITLGCSKSQQRQIMLW 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  246 APEDLSTPIVEEELDTSNGVVFPFYDEDSGLVYLVGKGDCAIRYYEVNNDAPYVHYinTYTTNEPQRAVGFQSKRGMSSE 325
Cdd:PTZ00421 243 DTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDTR 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  326 ENEINRIYKLTTKGVVDIlQFFVPRK-SDL-FQHDLYPDTRSTIPALTAEEFMEGKNAAP 383
Cdd:PTZ00421 321 KCEIARFYALTYHSLYTI-QMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEP 379
PLN02226 super family cl31848
2-oxoglutarate dehydrogenase E2 component
 401-497 2.71e-04

2-oxoglutarate dehydrogenase E2 component


The actual alignment was detected with superfamily member PLN02226:

Pssm-ID: 177871 [Multi-domain]  Cd Length: 463  Bit Score: 43.59  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  401 VQVAKKANILSTLAPTAAESVPtqsySERPPSSQQPSPRPSASPRPRPVVDDDMGIVTMREAPPSRPASSRASRTEIPPK 480
Cdd:PLN02226 156 VEPGTKVAIISKSEDAASQVTP----SQKIPETTDPKPSPPAEDKQKPKVESAPVAEKPKAPSSPPPPKQSAKEPQLPPK 231

                         90       100
                 ....*....|....*....|
gi 25150738  481 EESKVDPM---KPKQAVQLK 497
Cdd:PLN02226 232 ERERRVPMtrlRKRVATRLK 251
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 8-383 4.92e-76

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 250.58  E-value: 4.92e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738    8 SKFRHVFCKPVKHESCMSDIRVTEITWD-SLFCDVNPKFIAFINRGAGGPfMVIPVNKIGRVDKDYPFVDAHKAPCLEVA 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGST-AVLKHTDYGKLASNPPILLGQEGPIIDVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   87 WSPFNDNVIASCSEDTTCKVWVIPDRGLNRNLSEPAVELTGHQKRVNTIAWHPVANNVLLTAGGENVMFMWNVGTGEALL 166
Cdd:PTZ00421  83 FNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  167 EISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVKPQRAIFVK-DGLILSTGFTKRSERLYALR 245
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKrKDLIITLGCSKSQQRQIMLW 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  246 APEDLSTPIVEEELDTSNGVVFPFYDEDSGLVYLVGKGDCAIRYYEVNNDAPYVHYinTYTTNEPQRAVGFQSKRGMSSE 325
Cdd:PTZ00421 243 DTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDTR 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  326 ENEINRIYKLTTKGVVDIlQFFVPRK-SDL-FQHDLYPDTRSTIPALTAEEFMEGKNAAP 383
Cdd:PTZ00421 321 KCEIARFYALTYHSLYTI-QMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEP 379
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-67 1.27e-27

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 105.66  E-value: 1.27e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150738     3 QIVRQSKFRHVFCKPVKHESCMSDIRVTEITWDSLFCDVNPKFIAFINRGAG-GPFMVIPVNKIGR 67
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-297 1.17e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 1.17e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  78 HKAPCLEVAWSPFnDNVIASCSEDTTCKVWvipdrglNRNLSEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVMFMW 157
Cdd:cd00200  50 HTGPVRDVAASAD-GTYLASGSSDKTIRLW-------DLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 158 NVGTGEALLEISGHPDQIWSINFNFDGsQFVTTCK-DKKIRILDSHTGEVVHEGMGHEG-VkpQRAIFVKDGLILSTGFT 235
Cdd:cd00200 121 DVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSqDGTIKLWDLRTGKCVATLTGHTGeV--NSVAFSPDGEKLLSSSS 197

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150738 236 KRSERLYalrapeDLSTPIVEEELDT-SNGVVFPFYDEDSGLVyLVGKGDCAIRYYEVNNDAP 297
Cdd:cd00200 198 DGTIKLW------DLSTGKCLGTLRGhENGVNSVAFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
77-267 7.09e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 7.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  77 AHKAPCLEVAWSPfNDNVIASCSEDTTCKVWVIPDRglnrnlsEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVMFM 156
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 157 WNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVkPQRAIFVKDGLILSTGFTK 236
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSAD 267

                       170       180       190
                ....*....|....*....|....*....|.
gi 25150738 237 RSERLYALRAPEDLSTpiVEEELDTSNGVVF 267
Cdd:COG2319 268 GTVRLWDLATGELLRT--LTGHSGGVNSVAF 296
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-200 2.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 25150738    161 TGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILD 200
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN02226 PLN02226
2-oxoglutarate dehydrogenase E2 component
 401-497 2.71e-04

2-oxoglutarate dehydrogenase E2 component


Pssm-ID: 177871 [Multi-domain]  Cd Length: 463  Bit Score: 43.59  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  401 VQVAKKANILSTLAPTAAESVPtqsySERPPSSQQPSPRPSASPRPRPVVDDDMGIVTMREAPPSRPASSRASRTEIPPK 480
Cdd:PLN02226 156 VEPGTKVAIISKSEDAASQVTP----SQKIPETTDPKPSPPAEDKQKPKVESAPVAEKPKAPSSPPPPKQSAKEPQLPPK 231

                         90       100
                 ....*....|....*....|
gi 25150738  481 EESKVDPM---KPKQAVQLK 497
Cdd:PLN02226 232 ERERRVPMtrlRKRVATRLK 251
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 386-535 3.03e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 43.93  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   386 QPVNAAAAAAAAKPKVQVAKKANIL--STLAPTAAESV-PTQSYSERPPSS-------QQPSPRPSASPRPRPVVDDDMG 455
Cdd:NF033875   56 QPDNPDPQSGSETPKTAVSEEATVQkdTTSQPTKVEEVaSEKNGAEQSSATpndttnaQQPTVGAEKSAQEQPVVSPETT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   456 IVTMREAPPSRPASSRASRTEIPPKE-----------ESKVDP-----MKPKQ---AVQLKSRAARDEPGGGAQTAGQRR 516
Cdd:NF033875  136 NEPLGQPTEVAPAENEANKSTSIPKEfetpdvdkavdEAKKDPnitvvEKPAEdlgNVSSKDLAAKEKEVDQLQKEQAKK 215

                         170
                  ....*....|....*....
gi 25150738   517 AAAELERIKRDQSRTADED 535
Cdd:NF033875  216 IAQQAAELKAKNEKIAKEN 234
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 8-383 4.92e-76

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 250.58  E-value: 4.92e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738    8 SKFRHVFCKPVKHESCMSDIRVTEITWD-SLFCDVNPKFIAFINRGAGGPfMVIPVNKIGRVDKDYPFVDAHKAPCLEVA 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGST-AVLKHTDYGKLASNPPILLGQEGPIIDVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   87 WSPFNDNVIASCSEDTTCKVWVIPDRGLNRNLSEPAVELTGHQKRVNTIAWHPVANNVLLTAGGENVMFMWNVGTGEALL 166
Cdd:PTZ00421  83 FNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  167 EISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVKPQRAIFVK-DGLILSTGFTKRSERLYALR 245
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKrKDLIITLGCSKSQQRQIMLW 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  246 APEDLSTPIVEEELDTSNGVVFPFYDEDSGLVYLVGKGDCAIRYYEVNNDAPYVHYinTYTTNEPQRAVGFQSKRGMSSE 325
Cdd:PTZ00421 243 DTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDTR 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  326 ENEINRIYKLTTKGVVDIlQFFVPRK-SDL-FQHDLYPDTRSTIPALTAEEFMEGKNAAP 383
Cdd:PTZ00421 321 KCEIARFYALTYHSLYTI-QMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEP 379
PTZ00420 PTZ00420
coronin; Provisional
 77-380 2.15e-47

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 175.14  E-value: 2.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   77 AHKAPCLEVAWSPFNDNVIASCSEDTTCKVWVIPDRGLNRN-LSEPAVELTGHQKRVNTIAWHPVANNVLLTAGGENVMF 155
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  156 MWNVGTGEALLEISgHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVKPQRAIFVkDGL------I 229
Cdd:PTZ00420 152 IWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIWI-DGLggddnyI 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  230 LSTGFTKRSERLYALRAPEDLSTPIVEEELDTSNGVVFPFYDEDSGLVYLVGKGDCAIRYYEVNNDApyVHYINTYTTNE 309
Cdd:PTZ00420 230 LSTGFSKNNMREMKLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCS 307

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25150738  310 PQRAVGFQSKRGMSSEENEINRIYKLTTKGVVDILQFFVPRK-SDLFQHDLYPDTRSTIPALTAEEFMEGKN 380
Cdd:PTZ00420 308 PFRSFGFLPKQICDVYKCEIGRVYKNENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKD 379
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-67 1.27e-27

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 105.66  E-value: 1.27e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150738     3 QIVRQSKFRHVFCKPVKHESCMSDIRVTEITWDSLFCDVNPKFIAFINRGAG-GPFMVIPVNKIGR 67
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-297 1.17e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 1.17e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  78 HKAPCLEVAWSPFnDNVIASCSEDTTCKVWvipdrglNRNLSEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVMFMW 157
Cdd:cd00200  50 HTGPVRDVAASAD-GTYLASGSSDKTIRLW-------DLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 158 NVGTGEALLEISGHPDQIWSINFNFDGsQFVTTCK-DKKIRILDSHTGEVVHEGMGHEG-VkpQRAIFVKDGLILSTGFT 235
Cdd:cd00200 121 DVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSqDGTIKLWDLRTGKCVATLTGHTGeV--NSVAFSPDGEKLLSSSS 197

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150738 236 KRSERLYalrapeDLSTPIVEEELDT-SNGVVFPFYDEDSGLVyLVGKGDCAIRYYEVNNDAP 297
Cdd:cd00200 198 DGTIKLW------DLSTGKCLGTLRGhENGVNSVAFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
77-267 7.09e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 7.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  77 AHKAPCLEVAWSPfNDNVIASCSEDTTCKVWVIPDRglnrnlsEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVMFM 156
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 157 WNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVkPQRAIFVKDGLILSTGFTK 236
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSAD 267

                       170       180       190
                ....*....|....*....|....*....|.
gi 25150738 237 RSERLYALRAPEDLSTpiVEEELDTSNGVVF 267
Cdd:COG2319 268 GTVRLWDLATGELLRT--LTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
75-252 1.14e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 1.14e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  75 VDAHKAPCLEVAWSPfNDNVIASCSEDTTCKVWvipdrglNRNLSEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVM 154
Cdd:COG2319 200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLW-------DLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTV 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 155 FMWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGvkPQRAI-FVKDGLILSTG 233
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVaFSPDGKTLASG 348

                       170
                ....*....|....*....
gi 25150738 234 FTKRSERLYALRAPEDLST 252
Cdd:COG2319 349 SDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-215 1.84e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  77 AHKAPCLEVAWSPFNDnVIASCSEDTTCKVWVIPDRGLNRNLsepavelTGHQKRVNTIAWHPvANNVLLTAGGENVMFM 156
Cdd:cd00200 133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATL-------TGHTGEVNSVAFSP-DGEKLLSSSSDGTIKL 203

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 25150738 157 WNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEG 215
Cdd:cd00200 204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN 262
WD40 COG2319
WD40 repeat [General function prediction only];
76-233 3.70e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 3.70e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  76 DAHKAPCLEVAWSPfNDNVIASCSEDTTCKVWvipdrglNRNLSEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVMF 155
Cdd:COG2319 243 TGHSGSVRSVAFSP-DGRLLASGSADGTVRLW-------DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25150738 156 MWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGvKPQRAIFVKDGLILSTG 233
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
76-203 2.22e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 2.22e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  76 DAHKAPCLEVAWSPfNDNVIASCSEDTTCKVWvipdrglNRNLSEPAVELTGHQKRVNTIAWHPVaNNVLLTAGGENVMF 155
Cdd:COG2319 285 TGHSGGVNSVAFSP-DGKLLASGSDDGTVRLW-------DLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVR 355

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 25150738 156 MWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHT 203
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-198 9.17e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 9.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  77 AHKAPCLEVAWSPfNDNVIASCSEDTTCKVWvipdrglnrNLSEPAV--ELTGHQKRVNTIAWHPvaNNVLLTAGGE-NV 153
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW---------DLSTGKClgTLRGHENGVNSVAFSP--DGYLLASGSEdGT 242

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25150738 154 MFMWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRI 198
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 124-294 5.98e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 5.98e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 124 ELTGHQKRVNTIAWHPVaNNVLLTAGGENVMFMWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHT 203
Cdd:cd00200   4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 204 GEVVHEGMGHEgvKPQRAI-FVKDGLILSTGFTKRSERLYALRAPEDLSTpiVEEELDTSNGVVFpfyDEDSGLVYlVGK 282
Cdd:cd00200  83 GECVRTLTGHT--SYVSSVaFSPDGRILSSSSRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAF---SPDGTFVA-SSS 154

                       170
                ....*....|..
gi 25150738 283 GDCAIRYYEVNN 294
Cdd:cd00200 155 QDGTIKLWDLRT 166
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 344-383 2.06e-14

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 67.54  E-value: 2.06e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 25150738   344 LQFFVPRKS-DLFQHDLYPDTRSTIPALTAEEFMEGKNAAP 383
Cdd:pfam16300   4 ISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
77-252 6.88e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 6.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  77 AHKAPCLEVAWSPFNDNVIASCSEDTTCKVWVIPDRGLNRnlsepaveLTGHQKRVNTIAWHPvANNVLLTAGGENVMFM 156
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--------LLGHTAAVLSVAFSP-DGRLLASASADGTVRL 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 157 WNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGvKPQRAIFVKDGLILSTGFTK 236
Cdd:COG2319 105 WDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDD 183

                       170
                ....*....|....*.
gi 25150738 237 RSERLYALRAPEDLST 252
Cdd:COG2319 184 GTVRLWDLATGKLLRT 199
WD40 COG2319
WD40 repeat [General function prediction only];
107-252 2.27e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 2.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738 107 WVIPDRGLNRNLSEPAVELTGHQKRVNTIAWHPvANNVLLTAGGENVMFMWNVGTGEALLEISGHPDQIWSINFNFDGSQ 186
Cdd:COG2319  14 ADLALALLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150738 187 FVTTCKDKKIRILDSHTGEVVHEGMGHEGVkPQRAIFVKDGLILSTGFTKRSERLYALRAPEDLST 252
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-200 2.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 25150738    161 TGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILD 200
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
162-200 4.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 25150738   162 GEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILD 200
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 76-107 6.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 6.57e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 25150738     76 DAHKAPCLEVAWSPfNDNVIASCSEDTTCKVW 107
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PLN02226 PLN02226
2-oxoglutarate dehydrogenase E2 component
 401-497 2.71e-04

2-oxoglutarate dehydrogenase E2 component


Pssm-ID: 177871 [Multi-domain]  Cd Length: 463  Bit Score: 43.59  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  401 VQVAKKANILSTLAPTAAESVPtqsySERPPSSQQPSPRPSASPRPRPVVDDDMGIVTMREAPPSRPASSRASRTEIPPK 480
Cdd:PLN02226 156 VEPGTKVAIISKSEDAASQVTP----SQKIPETTDPKPSPPAEDKQKPKVESAPVAEKPKAPSSPPPPKQSAKEPQLPPK 231

                         90       100
                 ....*....|....*....|
gi 25150738  481 EESKVDPM---KPKQAVQLK 497
Cdd:PLN02226 232 ERERRVPMtrlRKRVATRLK 251
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 386-535 3.03e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 43.93  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   386 QPVNAAAAAAAAKPKVQVAKKANIL--STLAPTAAESV-PTQSYSERPPSS-------QQPSPRPSASPRPRPVVDDDMG 455
Cdd:NF033875   56 QPDNPDPQSGSETPKTAVSEEATVQkdTTSQPTKVEEVaSEKNGAEQSSATpndttnaQQPTVGAEKSAQEQPVVSPETT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   456 IVTMREAPPSRPASSRASRTEIPPKE-----------ESKVDP-----MKPKQ---AVQLKSRAARDEPGGGAQTAGQRR 516
Cdd:NF033875  136 NEPLGQPTEVAPAENEANKSTSIPKEfetpdvdkavdEAKKDPnitvvEKPAEdlgNVSSKDLAAKEKEVDQLQKEQAKK 215

                         170
                  ....*....|....*....
gi 25150738   517 AAAELERIKRDQSRTADED 535
Cdd:NF033875  216 IAQQAAELKAKNEKIAKEN 234
WD40 pfam00400
WD domain, G-beta repeat;
76-107 3.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.37e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 25150738    76 DAHKAPCLEVAWSPfNDNVIASCSEDTTCKVW 107
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 115-181 4.96e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 4.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25150738  115 NRNLSEPAVELTGHQKrVNTIAWHPVANNVLLTAGGENVMFMWNVGTGEALLEISGHPDQIWSINFN 181
Cdd:PLN00181 519 GRDIHYPVVELASRSK-LSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS 584
PHA03247 PHA03247
large tegument protein UL36; Provisional
 420-519 7.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738   420 SVPTQSYSERPPSSQQPSPRPSASPRPRPVVDddmgivtmreAPPSRPASSRASR---------TEIPPKEESKVDPMKP 490
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT----------HAPDPPPPSPSPAanepdphppPTVPPPERPRDDPAPG 2659

                          90       100
                  ....*....|....*....|....*....
gi 25150738   491 KQAVQLKSRAARDEPGGGAQTAGQRRAAA 519
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPRRRAA 2688
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
366-520 1.72e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  366 TIPALTAEEFMEGKNAAPNRQPVNAAAAAAAAKPKVQVAKKANilstlAPTAAESVPTQSYSERPPSSQQPSPRPS---- 441
Cdd:PRK12323 385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS-----PAPEALAAARQASARGPGGAPAPAPAPAaapa 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  442 -------ASPRPRPVVDDDMgivtmrEAPPSRPASSRASRTEIPPKEESKVDPMKPKQAVQLKSRAARDEPG----GGAQ 510
Cdd:PRK12323 460 aaarpaaAGPRPVAAAAAAA------PARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESipdpATAD 533

                        170
                 ....*....|
gi 25150738  511 TAGQRRAAAE 520
Cdd:PRK12323 534 PDDAFETLAP 543
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 414-518 3.85e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 3.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150738  414 APTAAESVPTQSYSERPPSSQQPSPRPSASPRPRPVVDDDMGIVTMREAPPSRPASSRASRTEIPPkeeskVDPMKPKQA 493
Cdd:PRK07764 419 AAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAP-----PAAPAPAAA 493

                         90       100
                 ....*....|....*....|....*
gi 25150738  494 VQlksRAARDEPGGGAQTAGQRRAA 518
Cdd:PRK07764 494 PA---APAAPAAPAGADDAATLRER 515
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-158 4.30e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 25150738    124 ELTGHQKRVNTIAWHPvANNVLLTAGGENVMFMWN 158
Cdd:smart00320   7 TLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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