NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|808356044|ref|NP_741414|]
View 

Ion transport domain-containing protein [Caenorhabditis elegans]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
368-594 2.08e-31

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 124.30  E-value: 2.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   368 SMYFQCFVIIFVVINAIgnAMFVYRHDETDKPRKYNFYLFEVGFTILFNVECIIKILCYGF-RNFIRRGIFKFELILCLG 446
Cdd:pfam00520    1 SRYFELFILLLILLNTI--FLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   447 S----SLNCVKFFYERNYFTYFQTFRLLRLIKASPILEDFVWKIFSPGKKLGGLVIFTIAFICCYSAISLQLF------- 515
Cdd:pfam00520   79 SlislVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktw 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   516 -YSVPNLHHFRTFPQAFMSMFQIITQEGWTDFVVEVLRATDdnlVPLVALYFVAYHLFVTLIVLSLFVAVILDNLEMDEE 594
Cdd:pfam00520  159 eNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1199-1468 2.99e-28

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 115.06  E-value: 2.99e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1199 SRWFNQAFALLVVLNSFTLVIPWNVEEEEQRATYVFTVTAlaaFMNMLFVIEIILKVIAYTFSG-FWQSRRNRVDLLITV 1277
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDY---VFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1278 FGVIWIFLHFFVALPSSKIdvdvqveLKkftytfgyLVVILRFFTIASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLF 1357
Cdd:pfam00520   78 PSLISLVLSSVGSLSGLRV-------LR--------LLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1358 YAYTGVILFPMVKYGMA--VSKHVNFRTASEALVVLFRCLTGEDWNDIMHDCMRSAPFCYwnegmnywetdcgnfygAII 1435
Cdd:pfam00520  143 FAIIGYQLFGGKLKTWEnpDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFW-----------------AYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 808356044  1436 YFCSFYLIITYIVRNLLVAVIMENFSLFYSSEE 1468
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
870-1148 7.61e-25

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 105.04  E-value: 7.61e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   870 PYIDWAMATVTIVSCISMLFESPWPttgeNLVMNNGYLQISDYFFVLSMTFELCVKIIANGLFftpKAVVRDVGGVMNLF 949
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQ----PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFV 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   950 IYFTSVIFLawMPKHVEINSLAQFLMICRAMRPLRIYTLVPHIRRVVLEFFRGFKEILLVTILMIVVMFIFASFGVQIVG 1029
Cdd:pfam00520   75 VVLPSLISL--VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1030 GKLAACNDPtvssrenctgvfwqklfvtrlevygkdteamhpkimvprvwtNPRNFNFDHVGNAMLALFETLSFKGWN-V 1108
Cdd:pfam00520  153 GKLKTWENP------------------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGdI 190
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 808356044  1109 IRDILWSRHGPWAVVFIHIYVFIGCMIGLTLFVGVVIANY 1148
Cdd:pfam00520  191 MYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNF 230
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
21-317 3.40e-22

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 97.34  E-value: 3.40e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044    21 EWALKIACTISMITVCIHTPrtIELFQPLNYIILAADFISVSIFMLDSVLRIHYEGIFRcdsSYLSNRWSQFSVFISIIH 100
Cdd:pfam00520    5 ELFILLLILLNTIFLALETY--FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   101 LLSFLLhcyqlidnffpflhlNYRAWYGAIRSIRPFIIIRLIPLVVKFKLPKNRIeQLLKRSSQQVKNVTLFFVFFMTLY 180
Cdd:pfam00520   80 LISLVL---------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLV-NSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   181 AIFGIQLFGRMDYHCVQPKTDPNNvtimdlaipdtmcapegiggyecpapmvcmqlnlnakgegfygmFNDFGASVFTVY 260
Cdd:pfam00520  144 AIIGYQLFGGKLKTWENPDNGRTN--------------------------------------------FDNFPNAFLWLF 179
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 808356044   261 LAASEEGWVYVLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETFAEIRVQ 317
Cdd:pfam00520  180 QTMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
368-594 2.08e-31

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 124.30  E-value: 2.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   368 SMYFQCFVIIFVVINAIgnAMFVYRHDETDKPRKYNFYLFEVGFTILFNVECIIKILCYGF-RNFIRRGIFKFELILCLG 446
Cdd:pfam00520    1 SRYFELFILLLILLNTI--FLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   447 S----SLNCVKFFYERNYFTYFQTFRLLRLIKASPILEDFVWKIFSPGKKLGGLVIFTIAFICCYSAISLQLF------- 515
Cdd:pfam00520   79 SlislVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktw 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   516 -YSVPNLHHFRTFPQAFMSMFQIITQEGWTDFVVEVLRATDdnlVPLVALYFVAYHLFVTLIVLSLFVAVILDNLEMDEE 594
Cdd:pfam00520  159 eNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1199-1468 2.99e-28

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 115.06  E-value: 2.99e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1199 SRWFNQAFALLVVLNSFTLVIPWNVEEEEQRATYVFTVTAlaaFMNMLFVIEIILKVIAYTFSG-FWQSRRNRVDLLITV 1277
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDY---VFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1278 FGVIWIFLHFFVALPSSKIdvdvqveLKkftytfgyLVVILRFFTIASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLF 1357
Cdd:pfam00520   78 PSLISLVLSSVGSLSGLRV-------LR--------LLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1358 YAYTGVILFPMVKYGMA--VSKHVNFRTASEALVVLFRCLTGEDWNDIMHDCMRSAPFCYwnegmnywetdcgnfygAII 1435
Cdd:pfam00520  143 FAIIGYQLFGGKLKTWEnpDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFW-----------------AYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 808356044  1436 YFCSFYLIITYIVRNLLVAVIMENFSLFYSSEE 1468
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
870-1148 7.61e-25

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 105.04  E-value: 7.61e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   870 PYIDWAMATVTIVSCISMLFESPWPttgeNLVMNNGYLQISDYFFVLSMTFELCVKIIANGLFftpKAVVRDVGGVMNLF 949
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQ----PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFV 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   950 IYFTSVIFLawMPKHVEINSLAQFLMICRAMRPLRIYTLVPHIRRVVLEFFRGFKEILLVTILMIVVMFIFASFGVQIVG 1029
Cdd:pfam00520   75 VVLPSLISL--VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1030 GKLAACNDPtvssrenctgvfwqklfvtrlevygkdteamhpkimvprvwtNPRNFNFDHVGNAMLALFETLSFKGWN-V 1108
Cdd:pfam00520  153 GKLKTWENP------------------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGdI 190
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 808356044  1109 IRDILWSRHGPWAVVFIHIYVFIGCMIGLTLFVGVVIANY 1148
Cdd:pfam00520  191 MYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNF 230
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
21-317 3.40e-22

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 97.34  E-value: 3.40e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044    21 EWALKIACTISMITVCIHTPrtIELFQPLNYIILAADFISVSIFMLDSVLRIHYEGIFRcdsSYLSNRWSQFSVFISIIH 100
Cdd:pfam00520    5 ELFILLLILLNTIFLALETY--FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   101 LLSFLLhcyqlidnffpflhlNYRAWYGAIRSIRPFIIIRLIPLVVKFKLPKNRIeQLLKRSSQQVKNVTLFFVFFMTLY 180
Cdd:pfam00520   80 LISLVL---------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLV-NSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   181 AIFGIQLFGRMDYHCVQPKTDPNNvtimdlaipdtmcapegiggyecpapmvcmqlnlnakgegfygmFNDFGASVFTVY 260
Cdd:pfam00520  144 AIIGYQLFGGKLKTWENPDNGRTN--------------------------------------------FDNFPNAFLWLF 179
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 808356044   261 LAASEEGWVYVLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETFAEIRVQ 317
Cdd:pfam00520  180 QTMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
497-587 4.84e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 41.85  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  497 VIFTIAFICcYSAISLQLF-YSVPnlhHFRTFPQAFMSMFQIITqeGWTDFVVEVLRATDDNLVPLVALYFVAYHLFVTL 575
Cdd:PLN03223 1335 VIFGMVFVG-YAFIGHVIFgNASV---HFSDMTDSINSLFENLL--GDITYFNEDLKNLTGLQFVVGMIYFYSYNIFVFM 1408
                          90
                  ....*....|..
gi 808356044  576 IVLSLFVAVILD 587
Cdd:PLN03223 1409 ILFNFLLAIICD 1420
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
368-594 2.08e-31

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 124.30  E-value: 2.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   368 SMYFQCFVIIFVVINAIgnAMFVYRHDETDKPRKYNFYLFEVGFTILFNVECIIKILCYGF-RNFIRRGIFKFELILCLG 446
Cdd:pfam00520    1 SRYFELFILLLILLNTI--FLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   447 S----SLNCVKFFYERNYFTYFQTFRLLRLIKASPILEDFVWKIFSPGKKLGGLVIFTIAFICCYSAISLQLF------- 515
Cdd:pfam00520   79 SlislVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktw 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   516 -YSVPNLHHFRTFPQAFMSMFQIITQEGWTDFVVEVLRATDdnlVPLVALYFVAYHLFVTLIVLSLFVAVILDNLEMDEE 594
Cdd:pfam00520  159 eNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1199-1468 2.99e-28

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 115.06  E-value: 2.99e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1199 SRWFNQAFALLVVLNSFTLVIPWNVEEEEQRATYVFTVTAlaaFMNMLFVIEIILKVIAYTFSG-FWQSRRNRVDLLITV 1277
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDY---VFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1278 FGVIWIFLHFFVALPSSKIdvdvqveLKkftytfgyLVVILRFFTIASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLF 1357
Cdd:pfam00520   78 PSLISLVLSSVGSLSGLRV-------LR--------LLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1358 YAYTGVILFPMVKYGMA--VSKHVNFRTASEALVVLFRCLTGEDWNDIMHDCMRSAPFCYwnegmnywetdcgnfygAII 1435
Cdd:pfam00520  143 FAIIGYQLFGGKLKTWEnpDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFW-----------------AYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 808356044  1436 YFCSFYLIITYIVRNLLVAVIMENFSLFYSSEE 1468
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
870-1148 7.61e-25

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 105.04  E-value: 7.61e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   870 PYIDWAMATVTIVSCISMLFESPWPttgeNLVMNNGYLQISDYFFVLSMTFELCVKIIANGLFftpKAVVRDVGGVMNLF 949
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQ----PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFV 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   950 IYFTSVIFLawMPKHVEINSLAQFLMICRAMRPLRIYTLVPHIRRVVLEFFRGFKEILLVTILMIVVMFIFASFGVQIVG 1029
Cdd:pfam00520   75 VVLPSLISL--VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1030 GKLAACNDPtvssrenctgvfwqklfvtrlevygkdteamhpkimvprvwtNPRNFNFDHVGNAMLALFETLSFKGWN-V 1108
Cdd:pfam00520  153 GKLKTWENP------------------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGdI 190
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 808356044  1109 IRDILWSRHGPWAVVFIHIYVFIGCMIGLTLFVGVVIANY 1148
Cdd:pfam00520  191 MYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNF 230
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
21-317 3.40e-22

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 97.34  E-value: 3.40e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044    21 EWALKIACTISMITVCIHTPrtIELFQPLNYIILAADFISVSIFMLDSVLRIHYEGIFRcdsSYLSNRWSQFSVFISIIH 100
Cdd:pfam00520    5 ELFILLLILLNTIFLALETY--FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   101 LLSFLLhcyqlidnffpflhlNYRAWYGAIRSIRPFIIIRLIPLVVKFKLPKNRIeQLLKRSSQQVKNVTLFFVFFMTLY 180
Cdd:pfam00520   80 LISLVL---------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLV-NSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044   181 AIFGIQLFGRMDYHCVQPKTDPNNvtimdlaipdtmcapegiggyecpapmvcmqlnlnakgegfygmFNDFGASVFTVY 260
Cdd:pfam00520  144 AIIGYQLFGGKLKTWENPDNGRTN--------------------------------------------FDNFPNAFLWLF 179
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 808356044   261 LAASEEGWVYVLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETFAEIRVQ 317
Cdd:pfam00520  180 QTMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1236-1461 1.70e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.88  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1236 VTALAAFMnMLFVIEIILKVIAYTFSGF---WQSRR-------NRVDLLITVFGVIWIFLH------------FFVALPS 1293
Cdd:pfam08016    3 VTNRSLFI-LLCEIVFVVFFLYFVVEEIlkiRKHRPsylrsvwNLLDLAIVILSVVLIVLNiyrdfladrlikSVEASPV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1294 SKIDVDVQVELKK-FTYTFGYLV--VILRFFTIASRNSTLKMLMLTVIMSM--FRSFFIITALFLLVlfYAYTGVILFPm 1368
Cdd:pfam08016   82 TFIDFDRVAQLDNlYRIILAFLVflTWLKLFKVLRFNKTMSLFTKTLSRAWkdLAGFALMFVIFFFA--YAQFGYLLFG- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  1369 vkygmavSKHVNFRTASEALVVLFR-CLTGEDWNDIMHdcmrsapfcywnegmnywetdCGNFYGaIIYFCSFYLIITYI 1447
Cdd:pfam08016  159 -------TQAPNFSNFVKSILTLFRtILGDFGYNEIFS---------------------GNRVLG-PLLFLTFVFLVIFI 209
                          250
                   ....*....|....
gi 808356044  1448 VRNLLVAVIMENFS 1461
Cdd:pfam08016  210 LLNLFLAIINDSYV 223
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
497-587 4.84e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 41.85  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356044  497 VIFTIAFICcYSAISLQLF-YSVPnlhHFRTFPQAFMSMFQIITqeGWTDFVVEVLRATDDNLVPLVALYFVAYHLFVTL 575
Cdd:PLN03223 1335 VIFGMVFVG-YAFIGHVIFgNASV---HFSDMTDSINSLFENLL--GDITYFNEDLKNLTGLQFVVGMIYFYSYNIFVFM 1408
                          90
                  ....*....|..
gi 808356044  576 IVLSLFVAVILD 587
Cdd:PLN03223 1409 ILFNFLLAIICD 1420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH