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Conserved domains on  [gi|808356096|ref|NP_741440|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

G-protein coupled receptor( domain architecture ID 11606548)

G-protein coupled receptor (GPCR) transmits physiological signals from the outside of the cell to the inside by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
33-340 5.97e-44

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


:

Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 155.10  E-value: 5.97e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096  33 VFVGVIGLIVALISIVHNSLLFYTFsTSTVLRKRNLTYLMWISGCDVFISICYIAIMCVQVYTDYFVSFkLLVLWHDYLR 112
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSF-LSYFYAYFLP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 113 TAFTVSHITLSAASFLLMAATVERYLQSTADNRTLKLFQIlaTHRTYVVFCCFLASLIFRGTVFFEIEVVTQPNCTGFSS 192
Cdd:cd14978   79 YIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTP--RRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 193 -MGLAVVPMFGESMDVVWRFFIRKIVTVFLPFAVLAYFNAAIVMNVRRTDRDQtvkalvlFITVGTRGEVTRLRSRLRAV 271
Cdd:cd14978  157 yYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRR-------RLLRRRRRLLSRSQRRERRT 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808356096 272 TRMLVMVVTGYLLANILDIIIAFWETINIQSLqeLPSLYTVLSDISSFLPIAACALRLPIYTINDRQIR 340
Cdd:cd14978  230 TIMLIAVVIVFLICNLPAGILNILEAIFGESF--LSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFR 296
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
33-340 5.97e-44

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 155.10  E-value: 5.97e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096  33 VFVGVIGLIVALISIVHNSLLFYTFsTSTVLRKRNLTYLMWISGCDVFISICYIAIMCVQVYTDYFVSFkLLVLWHDYLR 112
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSF-LSYFYAYFLP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 113 TAFTVSHITLSAASFLLMAATVERYLQSTADNRTLKLFQIlaTHRTYVVFCCFLASLIFRGTVFFEIEVVTQPNCTGFSS 192
Cdd:cd14978   79 YIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTP--RRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 193 -MGLAVVPMFGESMDVVWRFFIRKIVTVFLPFAVLAYFNAAIVMNVRRTDRDQtvkalvlFITVGTRGEVTRLRSRLRAV 271
Cdd:cd14978  157 yYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRR-------RLLRRRRRLLSRSQRRERRT 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808356096 272 TRMLVMVVTGYLLANILDIIIAFWETINIQSLqeLPSLYTVLSDISSFLPIAACALRLPIYTINDRQIR 340
Cdd:cd14978  230 TIMLIAVVIVFLICNLPAGILNILEAIFGESF--LSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFR 296
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
33-340 5.97e-44

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 155.10  E-value: 5.97e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096  33 VFVGVIGLIVALISIVHNSLLFYTFsTSTVLRKRNLTYLMWISGCDVFISICYIAIMCVQVYTDYFVSFkLLVLWHDYLR 112
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSF-LSYFYAYFLP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 113 TAFTVSHITLSAASFLLMAATVERYLQSTADNRTLKLFQIlaTHRTYVVFCCFLASLIFRGTVFFEIEVVTQPNCTGFSS 192
Cdd:cd14978   79 YIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTP--RRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 193 -MGLAVVPMFGESMDVVWRFFIRKIVTVFLPFAVLAYFNAAIVMNVRRTDRDQtvkalvlFITVGTRGEVTRLRSRLRAV 271
Cdd:cd14978  157 yYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRR-------RLLRRRRRLLSRSQRRERRT 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808356096 272 TRMLVMVVTGYLLANILDIIIAFWETINIQSLqeLPSLYTVLSDISSFLPIAACALRLPIYTINDRQIR 340
Cdd:cd14978  230 TIMLIAVVIVFLICNLPAGILNILEAIFGESF--LSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFR 296
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
37-327 1.15e-07

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 52.68  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096  37 VIGLIVALISIVHNSLLFYTFSTSTVLRKRNLTYLMWISGCDVFISICYIAIMCVQVYTDYFVsfkllvlWHDYLRTAFT 116
Cdd:cd00637    3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWW-------FGDALCKLLG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 117 VSHITLSAASFLLMAA-TVERYLQSTadnRTLKLFQILATHRTY-VVFCCFLASLIFRGTVFFEIEVVTQPNCTGFSSMg 194
Cdd:cd00637   76 FLQSVSLLASILTLTAiSVDRYLAIV---HPLRYRRRFTRRRAKlLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356096 195 lavvPMFGESMDVVWRFFIrkIVTVFLPFAVLAYFNAAIVMNVRRTDRdqtvkalvLFITVGTRGEVTRLRSRLRAVTRM 274
Cdd:cd00637  152 ----WPDLTLSKAYTIFLF--VLLFLLPLLVIIVCYVRIFRKLRRHRR--------RIRSSSSNSSRRRRRRRERKVTKT 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 808356096 275 LVMVVTGYLLANILDIIIAFWETINiqslQELPSLYTVLSDISSFLPIAACAL 327
Cdd:cd00637  218 LLIVVVVFLLCWLPYFILLLLDVFG----PDPSPLPRILYFLALLLAYLNSAI 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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