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Conserved domains on  [gi|32566059|ref|NP_741589|]
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MIF4G domain-containing protein [Caenorhabditis elegans]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10650468)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats

CATH:  1.25.40.180
Gene Ontology:  GO:0005515|GO:0003723
SCOP:  4000569

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
173-372 4.96e-21

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


:

Pssm-ID: 214713  Cd Length: 200  Bit Score: 90.11  E-value: 4.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566059    173 EHEIEKAITELRALQLHSHSIQIEQWIGGAfcDEELAECIGSALCRHAIEGGGGSGVGKLCANFKYAPSigSFVKGLIIA 252
Cdd:smart00543   1 EKKVKGLINKLSPSNFESIIKELLKLNNSD--KNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNP--DFGSLLLER 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566059    253 LSQYLECR-HKIREDHFRMWISFIQFLTELYSNLGSDSKgelatIVFDVFNYLLRPPILEHVKIQE--LECLISILIKGG 329
Cdd:smart00543  77 LQEEFEKGlESEEESDKQRRLGLVRFLGELYNFQVLTSK-----IILELLKELLNDLTKLDPPRSDfsVECLLSLLPTCG 151
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 32566059    330 YDLERE-CPDRLALLKDLIRDAFIDV----SEPWARKMILLLLELGAS 372
Cdd:smart00543 152 KDLEREkSPKLLDEILERLQDYLLKKdkteLSSRLRFMLELLIELRKN 199
 
Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
173-372 4.96e-21

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 90.11  E-value: 4.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566059    173 EHEIEKAITELRALQLHSHSIQIEQWIGGAfcDEELAECIGSALCRHAIEGGGGSGVGKLCANFKYAPSigSFVKGLIIA 252
Cdd:smart00543   1 EKKVKGLINKLSPSNFESIIKELLKLNNSD--KNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNP--DFGSLLLER 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566059    253 LSQYLECR-HKIREDHFRMWISFIQFLTELYSNLGSDSKgelatIVFDVFNYLLRPPILEHVKIQE--LECLISILIKGG 329
Cdd:smart00543  77 LQEEFEKGlESEEESDKQRRLGLVRFLGELYNFQVLTSK-----IILELLKELLNDLTKLDPPRSDfsVECLLSLLPTCG 151
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 32566059    330 YDLERE-CPDRLALLKDLIRDAFIDV----SEPWARKMILLLLELGAS 372
Cdd:smart00543 152 KDLEREkSPKLLDEILERLQDYLLKKdkteLSSRLRFMLELLIELRKN 199
 
Name Accession Description Interval E-value
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
173-372 4.96e-21

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 90.11  E-value: 4.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566059    173 EHEIEKAITELRALQLHSHSIQIEQWIGGAfcDEELAECIGSALCRHAIEGGGGSGVGKLCANFKYAPSigSFVKGLIIA 252
Cdd:smart00543   1 EKKVKGLINKLSPSNFESIIKELLKLNNSD--KNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNP--DFGSLLLER 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566059    253 LSQYLECR-HKIREDHFRMWISFIQFLTELYSNLGSDSKgelatIVFDVFNYLLRPPILEHVKIQE--LECLISILIKGG 329
Cdd:smart00543  77 LQEEFEKGlESEEESDKQRRLGLVRFLGELYNFQVLTSK-----IILELLKELLNDLTKLDPPRSDfsVECLLSLLPTCG 151
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 32566059    330 YDLERE-CPDRLALLKDLIRDAFIDV----SEPWARKMILLLLELGAS 372
Cdd:smart00543 152 KDLEREkSPKLLDEILERLQDYLLKKdkteLSSRLRFMLELLIELRKN 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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